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https://www.readbyqxmd.com/read/28425178/sleep-quality-clinical-and-psychological-manifestations-in-women-with-systemic-lupus-erythematosus
#1
Virginia Moraleda, Germán Prados, María P Martínez, Ana I Sánchez, José M Sabio, Elena Miró
AIM: Sleep problems are a common complaint in systemic lupus erythematosus (SLE) patients. We analyzed sleep quality with subjective and objective measures in a sample with SLE and its possible relationships with the main manifestations of the disease. METHODS: Twenty-one women with SLE and 20 healthy women participated in the study. All participants were evaluated with actigraphy for a week and they completed self-report instruments of sleep quality, quality of life, fatigue, anxiety, depression and perceived stress...
April 19, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28407315/drugs-with-antidepressant-properties-affect-tryptophan-metabolites-differently-in-rodent-models-with-depression-like-behavior
#2
Amanda Eskelund, Yan Li, David P Budac, Heidi K Müller, Gulinello Maria, Connie Sanchez, Gregers Wegener
The metabolism of tryptophan through kynurenine and serotonin pathways is linked to depression. Here, effects of different drugs with antidepressant properties (vortioxetine, fluoxetine and ketamine) on various tryptophan metabolites in different brain regions and plasma were examined using tandem mass spectrometry (LC-MS/MS), in Flinders Sensitive Line (FSL) rats, a genetic rat model of depression, and its controls: Flinders Resistant Line (FRL) and Sprague-Dawley (SD) rats. Protein levels of kynurenine pathway enzymes were measured in the brains and livers of these rat strains...
April 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28406052/the-psychometric-properties-of-the-perceived-stress-scale-10-among-patients-with-systemic-lupus-erythematosus
#3
S D Mills, D Azizoddin, G Z Racaza, D J Wallace, M H Weisman, P M Nicassio
Objective Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by periods of remission and recurrent flares, which have been associated with stress. Despite the significance of stress in this disease, the Perceived Stress Scale-10 has yet to be psychometrically evaluated in patients with SLE. Methods Exploratory factor analysis was used to examine the structural validity of the Perceived Stress Scale-10 among patients with SLE ( N = 138) receiving medical care at Cedars Sinai Medical Center...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28371529/socioeconomic-predictors-of-incident-depression-in-systemic-lupus-erythematosus
#4
Natalie McCormick, Laura Trupin, Edward H Yelin, Patricia P Katz
Objective To assess different measures of socioeconomic status (SES) as predictors of incident depression among women with systemic lupus erythematosus (SLE). Methods Data derive from the 2010-2015 waves of the Lupus Outcomes Study, where individuals with confirmed SLE were interviewed annually by telephone. Depression was assessed with the Center for Epidemiological Studies Depression Scale (CES-D), using a validated lupus-specific cutoff (≥23) for major depressive disorder. Women interviewed in ≥2 consecutive waves, with scores <23 in the first wave (T1), were included...
March 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28367894/roles-of-serum-uric-acid-prolactin-levels-and-psychosocial-factors-in-oral-lichen-planus
#5
Akanksha Gupta, Ravi Prakash S Mohan, Swati Gupta, Sangeeta S Malik, Sumit Goel, Nagaraju Kamarthi
Free radicals play important roles in the mechanisms underlying lichen planus (LP). Uric acid (UA) is an important anti-oxidant in plasma. Prolactin (PRL) is an immunomodulatory hormone that may promote LP, as has been documented in other autoimmune disorders, such as systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. PRL has multiple immune-stimulatory effects and promotes the development of such autoimmune disorders. Prolactin and uric acid may serve as biomarkers of disease activity in lichen planus...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28338190/the-role-of-mir-146a-in-modulating-traf6-induced-inflammation-during-lupus-nephritis
#6
C-Z Zheng, Y-B Shu, Y-L Luo, J Luo
OBJECTIVE: Lupus nephritis (LN) is a major complication of systemic lupus erythematosus (SLE). A previous study showed decreased expression level of microRNA (miR)-146a in LN patients, indicating its possible role in LN pathogenesis. PATIENTS AND METHODS: A total of 98 LN patients were recruited, for the collection of renal tissue samples during biopsy or surgery. Another cohort of 15 patients who had renal tumor resection was recruited as the control group, for the further comparison of expression levels of miR-146a, TRAF6 and p-p65 in tissues...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28326218/course-of-neuropsychiatric-symptoms-during-flares-of-systemic-lupus-erythematosus-sle
#7
Gareth Garrett, Nicola Ambrose, Zaib Davids, Dorothea Bindman
We present the case of a seventeen-year-old girl who presents with an interesting course of neuropsychiatric symptoms during several flares of SLE. The patient was diagnosed at the age of thirteen and has had four flares in total. The latter two flares included cutaneous and neuropsychiatric symptoms. The most recent flare occurred when she was aged seventeen. She had cutaneous symptoms which coincided with an episode of hypomania. Her mental state further deteriorated following steroid treatment. She exhibited affective and psychotic symptoms...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28298561/charlson-comorbidity-index-is-related-to-organ-damage-in-systemic-lupus-erythematosus-data-from-korean-lupus-network-kornet-registry
#8
Seong-Kyu Kim, Jung-Yoon Choe, Shin-Seok Lee
OBJECTIVE: The aim of this study was to identify whether comorbidity status is associated with organ damage in patients with systemic lupus erythematosus (SLE). METHODS: A total of 502 patients with SLE enrolled in the KORean lupus Network were consecutively recruited. Data included demographics, age-adjusted Charlson Comorbidity Index (CCIa), disease activity indexes, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), the Medical Outcomes Study Short Form-36 health survey (SF-36) score, and the Beck Depression Inventory (BDI) score...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28273990/neurological-manifestations-in-systemic-lupus-erythematosus-a-single-centre-study-from-north-east-india
#9
Sanjeeb Kakati, Bhupen Barman, Sobur U Ahmed, Masaraf Hussain
INTRODUCTION: Neurological manifestations although common in Systemic Lupus Erythematosus (SLE), are often not recognized due to their diversed and varied presentation. Therefore, the study was planned to highlight the pattern of neurological involvement in SLE to help in early recognition. AIM: To study the pattern of neurological involvement in SLE and its correlation with disease activity and different investigation. MATERIALS AND METHODS: This hospital based prospective observational study was carried out from August 2009 to July 2010...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28261991/role-of-psychosocial-reserve-capacity-in-anxiety-and-depression-in-patients-with-systemic-lupus-erythematosus
#10
Geraldine Zamora-Racaza, Desiree R Azizoddin, Mariko L Ishimori, Sarah R Ormseth, Daniel J Wallace, Ester G Penserga, Lekeisha Sumner, Julia Ayeroff, Taylor Draper, Perry M Nicassio, Michael H Weisman
AIM: To examine the relationship between reserve capacity measures and anxiety/depression among patients with systemic lupus erythematosus (SLE) from Southern California (SoCal), United States and Manila, Philippines. METHODS: A total of 235 participants with SLE completed self-reported scales to assess anxiety/depression and psychosocial reserve capacity measures (self-esteem, optimism, personal mastery/coping skills, social support), socioeconomic status (SES) data, and Mexican SLE Disease Activity Index...
March 6, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28241758/clinical-trials-from-the-patient-perspective-survey-in-an-online-patient-community
#11
Pronabesh DasMahapatra, Priya Raja, Jeremy Gilbert, Paul Wicks
BACKGROUND: Developing new medicines relies on the successful conduct of clinical trials. As trial protocols become more arduous, it becomes harder to recruit and retain patient volunteers, although recent efforts such as OMERACT and I-SPY2 show that partnering with patients can be beneficial. We sought to describe drivers and barriers to trial participation, as well as condition-specific trial preferences. METHODS: An online survey was fielded via the patient-powered research network PatientsLikeMe to 1,621 members living with nine selected chronic health conditions...
February 27, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28239223/exercise-reduces-depressive-symptoms-in-adults-with-arthritis-evidential-value
#12
George A Kelley, Kristi S Kelley
PURPOSE: Determine whether evidential value exists that exercise reduces depressive symptoms in adults with arthritis and other rheumatic diseases. METHODS: Using data from a previous meta-analysis of 29 published studies that included 2449 participants (1470 exercise, 979 control) with fibromyalgia, osteoarthritis, rheumatoid arthritis or systemic lupus erythematosus, a novel, recently developed method, p-curve, was used to assess for evidential value and rule out selective reporting of statistically significant findings regarding exercise and depressive symptoms in adults with arthritis and other rheumatic diseases...
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28237708/serum-levels-of-brain-derived-neurotrophic-factor-are-associated-with-depressive-symptoms-in-patients-with-systemic-lupus-erythematosus
#13
Qing Zheng, Ming-Jun Xu, Jing Cheng, Jun-Min Chen, Ling Zheng, Zhan-Guo Li
OBJECTIVE: The aim of this study was to explore potential relationships between serum BDNF levels and depression in systemic lupus erythematosus (SLE) patients. METHODS: We included 208 consecutive SLE patients and 100 age-and sex-matched healthy controls. The presence of depressive symptoms was determined through the Beck Depression Inventory-II (BDI-II) score. RESULTS: The serum BDNF levels were significantly (P<0.0001) higher in SLE patients as compared to normal controls...
December 21, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28202399/the-epidemiology-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-the-uk
#14
Noel Frey, Janine Jossi, Michael Bodmer, Andreas Bircher, Susan S Jick, Christoph R Meier, Julia Spoendlin
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening mucocutaneous diseases. SJS/TEN mostly manifest as a reaction to new drug use, but little is known about their incidence and epidemiology. We conducted a large observational study on the epidemiology of SJS/TEN using data from the UK-based Clinical Practice Research Datalink. Among 551 validated SJS/TEN cases, we calculated an incidence rate of 5.76 SJS/TEN cases/million person-years between 1995 and 2013, which was consistent throughout the study period, and was highest in patients aged 1-10 years and ≥80 years...
February 12, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28196529/prevalence-of-depression-and-anxiety-in-systemic-lupus-erythematosus-a-systematic-review-and-meta-analysis
#15
Lijuan Zhang, Ting Fu, Rulan Yin, Qiuxiang Zhang, Biyu Shen
BACKGROUND: Systemic lupus erythematosus (SLE) patients are at high risk for depression and anxiety. However, the estimated prevalence of these disorders varies substantially between studies. This systematic review aimed to establish pooled prevalence levels of depression and anxiety among adult SLE patients. METHODS: We systematically reviewed databases including PubMed, Embase, PsycINFO, and the Cochrane database library from their inception to August 2016. Studies presenting data on depression and/or anxiety in adult SLE patients and having a sample size of at least 60 patients were included...
February 14, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28128787/an-invisible-student-population-accommodating-and-serving-college-students-with-lupus
#16
Neelam Agarwal, Vinod Kumar
BACKGROUND: Systemic Lupus Erythematosus (SLE), or lupus, is a chronic autoimmune disorder. Individuals with lupus face unique psychosocial and emotional challenges such as living with the unpredictability of the disease, symptoms such as fatigue, pain and depression, anxiety, cognitive problems, and coping with stress. OBJECTIVE: This article attempts to shed light on the role that lupus plays in the lives of college students in their academics and other unique psychosocial needs...
2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28128085/antiphospholipid-syndrome-with-anti%C3%AE-2glicoprotein-1-antibodies-as-the-cause-of-recurrent-tibial-vein-thrombosis-in-sapho-syndrome
#17
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28116413/using-actigraphy-and-mhealth-systems-for-an-objective-analysis-of%C3%A2-sleep-quality-on-systemic-lupus-erythematosus-patients
#18
Sara Balderas-Díaz, M Pilar Martínez, Gabriel Guerrero-Contreras, Elena Miró, Kawtar Benghazi, Ana I Sánchez, José Luis Garrido, Germán Prados
INTRODUCTION: Although sleep alterations can be an important factor contributing to the clinical state of Systemic Lupus Erythematosus, there are no studies to adequately assess sleep quality in this type of disease. OBJECTIVES: The aim of this work is to analyse the sleep quality of Systemic Lupus Erythematous (SLE) patients based on more objective information provided by actigraphy and mobile systems. The idea is to carry out a comprehensive study by analysing how environmental conditions and factors can affect sleep quality...
March 23, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28114336/factors-associated-with-health-related-quality-of-life-in-mexican-lupus-patients-using-the-lupusqol
#19
I Etchegaray-Morales, S Méndez-Martínez, C Jiménez-Hernández, C Mendoza-Pinto, N E Alonso-García, A Montiel-Jarquín, A López-Colombo, A García-Villaseñor, M H Cardiel, M García-Carrasco
INTRODUCTION: Health-related quality of life (HRQOL) is affected by numerous clinical variables, including disease activity, damage, fibromyalgia, depression and anxiety. However, these associations have not yet been described in Mexican patients with systemic lupus erythematosus (SLE). OBJECTIVE: To evaluate the relationship between disease activity, damage, depression and fibromyalgia and HRQOL measured by the LupusQoL-instrument in Mexican patients with SLE. METHODS: A cross-sectional study was conducted in women fulfilling the 1997 ACR classification criteria for SLE...
2017: PloS One
https://www.readbyqxmd.com/read/27914592/hyperuricemia-in-systemic-lupus-erythematosus-is-it-associated-with-the-neuropsychiatric-manifestations-of-the-disease
#20
Mahdi Sheikh, Shafieh Movassaghi, Mohammad Khaledi, Maryam Moghaddassi
OBJECTIVES: To assess the association between hyperuricemia and different neuropsychiatric manifestations and stroke risk factors in systematic lupus erythematosus (SLE) patients. METHODS: This study was conducted on 204 SLE patients who were admitted to a tertiary referral center. A standardized questionnaire was completed for all the participants and the medical records were reviewed regarding the occurrence of arterial or venous thrombotic events, stroke, seizure, depression, headache, psychosis, and peripheral neuropathy...
November 2016: Revista Brasileira de Reumatologia
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