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https://www.readbyqxmd.com/read/28345064/pneumocephalus-in-a-patient-with-multiple-stab-wounds
#1
Yusuf Savran, Volkan Karacam, Basak Bayram, Erdem Yaka, Nuri Karabay
Pneumocephalus is a complication of trauma to the chest and many iatrogenic interventions. It may arise due to systemic air embolism or retrograde cerebral venous air embolism which is an extremely rare complication. We report a 26-years-old female patient who presented to the Emergency Department suffering of multiple stab wounds. She was in a state of shock and after first aid and evaluation she was operated successfully. In the early postoperative period generalized tonic clonic convulsions were observed following cardiopulmonary resuscitation due to sudden cardiovascular collapse...
March 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28342423/a-bioinformatics-approach-to-designing-a-zika-virus-vaccine
#2
Sumanta Dey, Ashesh Nandy, Subhash C Basak, Papiya Nandy, Sukhen Das
The Zika virus infections have reached epidemic proportions in the Latin American countries causing severe birth defects and neurological disorders. While several organizations have begun research into design of prophylactic vaccines and therapeutic drugs, computer assisted methods with adequate data resources can be expected to assist in these measures to reduce lead times through bioinformatics approaches. Using 60 sequences of the Zika virus envelope protein available in the GenBank database, our analysis with numerical characterization techniques and several web based bioinformatics servers identified four peptide stretches on the Zika virus envelope protein that are well conserved and surface exposed and are predicted to have reasonable epitope binding efficiency...
March 10, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28341999/immunological-memory-to-hyperphosphorylated-tau-in-asymptomatic-individuals
#3
Gabriel Pascual, Jehangir S Wadia, Xueyong Zhu, Elissa Keogh, Başak Kükrer, Jeroen van Ameijde, Hanna Inganäs, Berdien Siregar, Gerrard Perdok, Otto Diefenbach, Tariq Nahar, Imke Sprengers, Martin H Koldijk, Els C Brinkman-van der Linden, Laura A Peferoen, Heng Zhang, Wenli Yu, Xinyi Li, Michelle Wagner, Veronica Moreno, Julie Kim, Martha Costa, Kiana West, Zara Fulton, Lucy Chammas, Nancy Luckashenak, Lauren Fletcher, Trevin Holland, Carrie Arnold, R Anthony Williamson, Jeroen J Hoozemans, Adrian Apetri, Frederique Bard, Ian A Wilson, Wouter Koudstaal, Jaap Goudsmit
Several reports have described the presence of antibodies against Alzheimer's disease-associated hyperphosphorylated forms of tau in serum of healthy individuals. To characterize the specificities that can be found, we interrogated peripheral IgG(+) memory B cells from asymptomatic blood donors for reactivity to a panel of phosphorylated tau peptides using a single-cell screening assay. Antibody sequences were recovered, cloned, and expressed as full-length IgGs. In total, 52 somatically mutated tau-binding antibodies were identified, corresponding to 35 unique clonal families...
March 24, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28331760/partial-breast-irradiation-current-situation-with-evidence
#4
EDITORIAL
Hale Başak Çağlar
No abstract text is available yet for this article.
January 2017: J Breast Health (2013)
https://www.readbyqxmd.com/read/28327628/corrigendum-pregnane-x-receptor-regulates-pathogen-induced-inflammation-and-host-defense-against-an-intracellular-bacterial-infection-through-toll-like-receptor-4
#5
Zhijuan Qiu, Jorge L Cervantes, Basak B Cicek, Subhajit Mukherjee, Madhukumar Venkatesh, Leigh A Maher, Juan C Salazar, Sridhar Mani, Kamal M Khanna
No abstract text is available yet for this article.
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325018/imquant-an-image-based-fluorescence-reader-for-quantitative-lateral-flow-immunoassays
#6
Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam
Fluorescence immunoassays (FIA) have strong potential in enabling rapid quantitative immunological testing at point of care. Existing state of the art instruments employ laser scanning of FIA test kits, which require the use of electromechanical systems, making the instrument bulky, heavy and less reliable in the long term. There is a growing need for an extremely compact and reliable, motion-free, automated reader for accurate quantification of immunoassays. Here, we present ImQuant, an image based FIA reader with integrated monochromatic excitation source, optical filtering and real time image capture, assisted with an intuitive graphical user interface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324092/association-between-choice-of-radical-prostatectomy-external-beam-radiotherapy-brachytherapy-or-active-surveillance-and-patient-reported-quality-of-life-among-men-with-localized-prostate-cancer
#7
COMPARATIVE STUDY
Ronald C Chen, Ramsankar Basak, Anne-Marie Meyer, Tzy-Mey Kuo, William R Carpenter, Robert P Agans, James R Broughman, Bryce B Reeve, Matthew E Nielsen, Deborah S Usinger, Kiayni C Spearman, Sarah Walden, Dianne Kaleel, Mary Anderson, Til Stürmer, Paul A Godley
Importance: Patients diagnosed with localized prostate cancer have to decide among treatment strategies that may differ in their likelihood of adverse effects. Objective: To compare quality of life (QOL) after radical prostatectomy, external beam radiotherapy, and brachytherapy vs active surveillance. Design, Setting, and Participants: Population-based prospective cohort of 1141 men (57% participation among eligible men) with newly diagnosed prostate cancer were enrolled from January 2011 through June 2013 in collaboration with the North Carolina Central Cancer Registry...
March 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28323921/emerging-roles-for-micrornas-in-diabetic-microvascular-disease-novel-targets-for-therapy
#8
Yu Zhang, Xinghui Sun, Basak Icli, Mark W Feinberg
Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs, non-coding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury...
February 17, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28322359/clinical-evaluation-of-a-fissure-sealant-placed-by-acid-etching-or-er-yag-laser-combined-with-acid-etching
#9
Basak Durmus, Figen Giray, Sertac Peker, Betul Kargul
PURPOSE: To evaluate the efficacy of conventional acid etching alone (acid etching) and Er:YAG laser combined with acid etching (laser + acid etching) on fissure sealant (FS) retention of first permanent molars (FPMs) after 18 months. MATERIALS AND METHODS: Using a split-mouth design in 51 children, a total of 204 FPMs were sealed with acid etching alone or laser plus acid etching (laser+acid). The retention of sealants and occurrence of caries were evaluated at 3, 6, 12, and 18 months...
March 20, 2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28319275/mrf-ann-a-machine-learning-approach-for-automated-er-scoring-of-breast-cancer-immunohistochemical-images
#10
T Mungle, S Tewary, D K DAS, I Arun, B Basak, S Agarwal, R Ahmed, S Chatterjee, C Chakraborty
Molecular pathology, especially immunohistochemistry, plays an important role in evaluating hormone receptor status along with diagnosis of breast cancer. Time-consumption and inter-/intraobserver variability are major hindrances for evaluating the receptor score. In view of this, the paper proposes an automated Allred Scoring methodology for estrogen receptor (ER). White balancing is used to normalize the colour image taking into consideration colour variation during staining in different labs. Markov random field model with expectation-maximization optimization is employed to segment the ER cells...
March 20, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28315402/spectral-domain-optical-coherence-tomography-findings-of-patients-under-treatment-for-pediatric-acute-lymphoblastic-leukemia
#11
Ozgur Yalcinbayir, Birol Baytan, Oner Gelisken, Basak Can, Melike Sezgin Evim, Meral Yildiz, Adalet Meral Gunes
PURPOSE: To investigate the use of spectral domain optical coherence tomography (SD-OCT) findings in pediatric acute lymphoblastic leukemia (ALL) patients. METHODS: Children that were diagnosed with precursor B-cell ALL and classified as belonging to the medium-risk group for relapse were selected for this study. Individuals who were in continuous remission and on maintenance therapy were included in the study group. Cases that had central nervous system involvement were excluded...
March 14, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28304388/pirfenidone-inhibits-post-traumatic-proliferative-vitreoretinopathy
#12
B N M K Khanum, R Guha, V P Sur, S Nandi, S K Basak, A Konar, S Hazra
PurposeThe purpose of the study was to evaluate the efficacy and safety of intravitreal pirfenidone for inhibition of proliferative vitreoretinopathy (PVR) in a model of penetrating ocular injury.Patients and methodsPenetrating trauma was induced on the retina of rabbit and treated either with 0.1 ml of phosphate-buffered saline (PBS) or 0.1 ml of 0.5% pirfenidone, and development of PVR was evaluated clinically and graded after 1 month. Histopathology and immunohistochemistry with transforming growth factor beta (TGFβ), alpha smooth muscle actin (αSMA), and collagen-1 were performed to assess the fibrotic changes...
March 17, 2017: Eye
https://www.readbyqxmd.com/read/28300734/residency-evaluation-and-adherence-design-study-young-ophthalmologists-perception-of-their-residency-programs-ii-academics-and-research-dissertation
#13
Parikshit Madhav Gogate, Partha Biswas, Sundaram Natarajan, Barun Kumar Nayak, Santhan Gopal, Yogesh Shah, Samar K Basak
PURPOSE: To know the perception of young ophthalmologists about their dissertation and academics during residency training in order to improve the research output during present residency programs in India. METHODS: A survey was conducted by Academic and Research Committee of the All India Ophthalmological Society, the world's second largest ophthalmic professional's organization, in 2014-2016 of young ophthalmologists (those who completed residency between 2005 and 2012) to gauge usefulness of dissertation or thesis during postgraduate residency...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28300408/olefination-with-sulfonyl-halides-and-esters-scope-limitations-and-mechanistic-studies-of-the-hawkins-reaction
#14
Bartosz Górski, Alicja Talko, Tymoteusz Basak, Michał Barbasiewicz
Carbanions of alkanesulfonyl halides and esters react with nonenolizable carbonyl compounds to give olefins. Mechanistic studies reveal that initial aldol-type addition of the carbanions is followed by cyclization-fragmentation to alkenes, and the leaving group on the sulfonyl moiety (RSO2X) controls carbanion stability and rate of the olefin formation.
March 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28294952/can-c-reactive-protein-levels-increase-the-accuracy-of-the-ranson-score-in-predicting-the-severity-and-prognosis-of-acute-pancreatitis-a-prospective-cohort-study
#15
Fatih Başak, Mustafa Hasbahçeci, Abdullah Şişik, Aylin Acar, Kemal Tekesin, Gürhan Baş, Orhan Alimoğlu
BACKGROUND/AIMS: Acute pancreatitis (AP) is an acute inflammatory disorder of the pancreas, and its severe form affects nearly all systems of the body. The purpose of this study is to assess the Ranson score and the C-reactive-protein level as a novel model for prediction of the disease severity and mortality. MATERIALS AND METHODS: A prospective cohort study was designed to evaluate the efficacy of the C-reactive-protein for the prediction of severe AP. We recorded the Ranson score and C-reactive-protein values in AP patients and determined the severity of the disease using the revised Atlanta classification...
March 15, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28281915/burden-of-community-acquired-pneumonia-in-adults-over-18%C3%A2-years-of-age
#16
Filiz Kosar, Devrim Emel Alici, Basak Hacibedel, Burcu Arpınar Yigitbas, Pejman Golabi, Caglar Cuhadaroglu
This study aimed to determine the economic burden and affecting factors in adult community-acquired pneumonia (CAP) patients (≥18 years) by retrospectively evaluating the data of two centers in Istanbul province, Turkey. Data of outpatients and inpatients with CAP from January 2013 through June 2014 were evaluated. The numbers of laboratory analyses, imaging, hospitalization days, and specialist visits were multiplied by the relevant unit costs and the costs of the relevant items per patient were obtained...
March 10, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28277117/structural-imaging-of-the-brain-reveals-decreased-total-brain-and-total-gray-matter-volumes-in-obese-but-not-in-lean-women-with-polycystic-ovary-syndrome-compared-to-body-mass-index-matched-counterparts
#17
Basak Ozgen Saydam, Arzu Ceylan Has, Gurkan Bozdag, Kader Karli Oguz, Bulent Okan Yildiz
PURPOSE: To detect differences in global brain volumes and identify relations between brain volume and appetite-related hormones in women with polycystic ovary syndrome (PCOS) compared to body mass index-matched controls. METHODS: Forty subjects participated in this study. Cranial magnetic resonance imaging and measurements of fasting ghrelin, leptin and glucagon-like peptide 1 (GLP-1), as well as GLP-1 levels during mixed-meal tolerance test (MTT), were performed...
March 1, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28274864/protective-effects-of-curcumin-against-gamma-ray-induced-conformational-change-of-human-serum-albumin
#18
Turban Kar, Pijush Basak, Rittik Kumar Ghosh, Maitree Bhattacharyya
This study explores the possibility for protection by curcumin during the molecular and structural changes of human serum albumin (HSA) exposed to gamma irradiation. We used a combination of spectroscopic methods to probe the conformational ensemble of the irradiated HSA and finally evaluated the extent of restoration by curcumin. SDS-PAGE study unfolded the formation of cross linked aggregates as a consequence of increasing exposure of gamma radiation. CD and FTIR spectroscopy indicated significant decrease in the alpha helix content of HSA from 57% to 15% with increasing radiation doses...
March 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28274402/patient-reported-quality-of-life-during-definitive-and-postprostatectomy-image-guided-radiation-therapy-for-prostate-cancer
#19
Kevin Diao, Emily A Lobos, Eda Yirmibesoglu, Ram Basak, Laura H Hendrix, Brittney Barbosa, Seth M Miller, Kevin A Pearlstein, Gregg H Goldin, Andrew Z Wang, Ronald C Chen
PURPOSE: The importance of patient-reported outcomes is well-recognized. Long-term patient-reported symptoms have been described for individuals who completed radiation therapy (RT) for prostate cancer. However, the trajectory of symptom development during the course of treatment has not been well-described in patients receiving modern, image-guided RT. METHODS AND MATERIALS: Quality-of-life data were prospectively collected for 111 prostate cancer patients undergoing RT using the validated Prostate Cancer Symptom Indices, which assessed 5 urinary obstructive/irritative and 6 bowel symptoms...
March 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28262093/crystal-structure-and-dynamics-of-a-lipid-induced-potential-desensitized-state-of-a-pentameric-ligand-gated-channel
#20
Sandip Basak, Nicolaus Schmandt, Yvonne Gicheru, Sudha Chakrapani
Desensitization in pentameric ligand-gated ion channels plays an important role in regulating neuronal excitability. Here, we show that docosahexaenoic acid (DHA), a key ω-3 polyunsaturated fatty acid in synaptic membranes, enhances the agonist-induced transition to the desensitized state in the prokaryotic channel GLIC. We determined a 3.25 Å structure of the GLIC-DHA complex in a potentially desensitized conformation. The DHA molecule is bound at the channel-periphery near M4 and exerts a long-range allosteric effect on the pore across domain-interfaces...
March 6, 2017: ELife
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