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https://www.readbyqxmd.com/read/29335810/sexual-and-reproductive-health-education-needs-gender-roles-attitudes-and-acceptance-of-couple-violence-according-to-engaged-men-and-women
#1
Fusun Terzioglu, Gulsah Kok, Gulten Guvenc, Funda Ozdemir, Ilknur Munevver Gonenc, Basak Demirtas Hicyilmaz, Neslihan Yılmaz Sezer
This descriptive study was aimed to evaluate the attitudes of the engaged men and women who are of legal age to marry towards gender roles and acceptance of couple violence, and determine their sexual/reproductive health education needs. It was conducted in two marriage registry offices in Ankara, Turkey. The study sample consisted of 740 participants. Data were collected by using semi-structured form, Gender Roles Attitude Scale and Acceptance of Couple Violence Scale. It was found that the engaged couples had educational needs concerning sexual/reproductive health; socio-demographic characteristics such as gender, age, education, residence, and income level created significant differences in the attitudes related to accepting gender roles and violence; and having an egalitarian attitude towards gender roles decreased the rate of accepting violence between the couples...
January 15, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29332418/the-role-of-pet-and-mri-in-evaluating-the-feasibility-of-skin-sparing-mastectomy-following-neoadjuvant-therapy
#2
Fatma Umit Malya, Huseyin Kadioglu, Huseyin Kazim Bektasoglu, Zuhal Gucin, Seyma Yildiz, Mehmet Guzel, Ezgi Basak Erdogan, Serap Yucel, Yeliz Emine Ersoy
Objective To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29332266/association-between-the-interferon-gamma-874-t-a-polymorphism-and-the-severity-of-valvular-damage-in-patients-with-rheumatic-heart-disease
#3
Erhan Teker, A Basak Akadam-Teker, Oguz Ozturk, Allison Pinar Eronat, Kivanc Yalin, S Ebru Golcuk, Zehra Bugra
Interferon gamma (IFN-γ) is a multifunctional cytokine that plays an important role in modulating almost all phases of the immune response and may be responsible for the increased valvular fibrosis and calcification in the pathogenesis of rheumatic heart disease (RHD). The aim of this study was to investigate the possible relationship between the IFN-γ +874 T/A polymorphism and the severity of valvular damage in the Turkish population. The IFN-γ genotypes were determined in 152 RHD patients and 151 healthy controls by ARMS-PCR...
January 13, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29330402/chronic-graft-versus-host-disease-features-in-double-unit-cord-blood-transplantation-according-to-national-institutes-of-health-2005-cgvhd-consensus-criteria
#4
Hiromi Hayashi, Annalisa Ruggeri, Fernanda Volt, Jan J Cornelissen, Gerard Socié, Henrik Sengeloev, Mauricette Michallet, Dimitrios Karakasis, Eefke Petersen, Jean Yves Cahn, Hendrik Veelken, Mélanie Mercier, Pierre-Simon Rohrlich, Hanadi Rafii, Chantal Kenzey, Erick Xavier, Rafael F Duarte, Grzegorz W Basak, Vanderson Rocha, Eliane Gluckman
No abstract text is available yet for this article.
January 12, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29326852/unusual-course-of-crystalline-keratopathy-in-a-patient-with-graft-versus-host-disease
#5
Başak Bostancı, Yonca Aydın Akova
We present a case of infectious crystalline keratopathy in a patient with Graft-versus-Host disease (GVHD) who developed satellite fungal keratitis. A 51-year-old man was referred for bilateral total persistent corneal epithelial defects with severe dry eye. Although persistent epithelial defect healed with medical therapy, he developed stromal keratitis with satellite lesions confirmed to be secondary to Candida albicans. After three months of antifungal treatment and debridement, improvement of the infiltrates was obtained...
December 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29323279/structural-basis-of-trpv5-channel-inhibition-by-econazole-revealed-by-cryo-em
#6
Taylor E T Hughes, David T Lodowski, Kevin W Huynh, Aysenur Yazici, John Del Rosario, Abhijeet Kapoor, Sandip Basak, Amrita Samanta, Xu Han, Sudha Chakrapani, Z Hong Zhou, Marta Filizola, Tibor Rohacs, Seungil Han, Vera Y Moiseenkova-Bell
The transient receptor potential vanilloid 5 (TRPV5) channel is a member of the transient receptor potential (TRP) channel family, which is highly selective for Ca2+, that is present primarily at the apical membrane of distal tubule epithelial cells in the kidney and plays a key role in Ca2+ reabsorption. Here we present the structure of the full-length rabbit TRPV5 channel as determined using cryo-EM in complex with its inhibitor econazole. This structure reveals that econazole resides in a hydrophobic pocket analogous to that occupied by phosphatidylinositides and vanilloids in TRPV1, thus suggesting conserved mechanisms for ligand recognition and lipid binding among TRPV channels...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29318995/sinistral-portal-hypertension-due-to-pancreatic-hydatid-cyst
#7
Tolga Canbak, Aylin Acar, Ali Ediz Kıvanç, Fatih Başak, Fatma Kulalı, Gürhan Baş
Hydatid disease is caused by Echinococcus granulosus. Hydatid cysts are commonly located in the liver and lungs. The occurrence of pancreatic hydatid cysts is very rare, even in endemic areas. Sinistral portal hypertension, which is rarely seen, occurs when a pathological process causes splenic vein occlusion. A 26-year-old male patient presented with abdominal pain. He had a history of operation for hydatid cyst of the lung 15 years ago. A left thoracotomy incision scar was observed during his physical examination...
December 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29317171/molecular-identification-of-blastocystis-sp-subtypes-in-water-samples-collected-from-black-sea-turkey
#8
Zeynep Koloren, Berivan Basak Gulabi, Panagiotis Karanis
The aim of this study was to identify the subtypes of Blastocystis sp. and complete a phylogenetic analysis of 268 water samples that were collected from the Samsun, Amasya and Sinop Provinces of the Black Sea in Turkey, between the years 2011 and 2014. Blastocystis sp. was investigated in 48 uncultured sea water samples that were collected from 4 sites within the Sinop Province. A total of 100 river water samples were collected from 37 sites in the Samsun Province and 120 river water samples were collected from 10 sampling sites within the Amasya Province...
January 6, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29311336/troy-brain-stem-cells-cycle-through-quiescence-and-regulate-their-number-by-sensing-niche-occupancy
#9
Onur Basak, Teresa G Krieger, Mauro J Muraro, Kay Wiebrands, Daniel E Stange, Javier Frias-Aldeguer, Nicolas C Rivron, Marc van de Wetering, Johan H van Es, Alexander van Oudenaarden, Benjamin D Simons, Hans Clevers
The adult mouse subependymal zone provides a niche for mammalian neural stem cells (NSCs). However, the molecular signature, self-renewal potential, and fate behavior of NSCs remain poorly defined. Here we propose a model in which the fate of active NSCs is coupled to the total number of neighboring NSCs in a shared niche. Using knock-in reporter alleles and single-cell RNA sequencing, we show that the Wnt target Tnfrsf19/Troy identifies both active and quiescent NSCs. Quantitative analysis of genetic lineage tracing of individual NSCs under homeostasis or in response to injury reveals rapid expansion of stem-cell number before some return to quiescence...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29303588/photochemical-activation-of-enediyne-warheads-a-potential-tool-for-targeted-antitumor-therapy
#10
Prabuddha Bhattacharya, Amit Basak, Adam Campbell, Igor V Alabugin
This review outlines recent approaches to further fine-tuning photoactivated enediyne "warheads" by using a variety of factors such as the release of internal strain, chelation, pH changes, modulations of photophysical approaches. Enediynes are shown to be a highly modifiable motif, and this review establishes a foundation upon which more advancements can be made to increase their efficacy. Many of the recent advances came from a productive interplay between oxidative DNA modification chemistry and unique properties of C-lysine conjugates, enabled by the presence of multiple amino groups of different basicity...
January 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29298069/identification-of-n-cis-3-methyl-7h-pyrrolo-2-3-d-pyrimidin-4-yl-amino-cyclobutyl-propane-1-sulfonamide-pf-04965842-a-selective-jak1-clinical-candidate-for-the-treatment-of-autoimmune-diseases
#11
Michael L Vazquez, Neelu Kaila, Joseph W Strohbach, John D Trzupek, Matthew F Brown, Mark E Flanagan, Mark J MItton-Fry, Timothy A Johnson, Ruth E TenBrink, Eric P Arnold, Arindrajit Basak, Steven E Heasley, Soojin Kwon, Jonathan Langille, Mihir D Parikh, Sarah H Griffin, Jeffrey M Casavant, Brian A Duclos, Ashley E Fenwick, Thomas M Harris, Seungil Han, Nicole L Caspers, Martin E Dowty, Xin Yang, Mary Ellen Banker, Martin Hegen, Peter T Symanowicz, Li Li, Lu Wang, Tsung H Lin, Jason Jussif, James D Clark, Jean-Baptiste Telliez, Ralph P Robinson, Ray Unwalla
Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous cytokines and growth factors involved in the regulation of immunity, inflammation and hematopoiesis. As JAK1 pairs with JAK2, JAK3 and TYK2, a JAK1-selective inhibitor would be expected to inhibit many cytokines involved in inflammation and immune function, while avoiding inhibition of the JAK2 homodimer regulating EPO and TPO signaling. Our efforts began with tofacitinib, an oral JAK inhibitor approved for the treatment of rheumatoid arthritis (RA)...
January 3, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29288757/do-flavanols-rich-natural-products-relieve-obesity-related-insulin-resistance
#12
REVIEW
Ayse Basak Engin, Aristidis M Tsatsakis, Dimitris Tsoukalas, Atilla Engin
Growing evidence support that insulin resistance may occur as a severe problem due to chronic energetic overfeeding and subsequent obesity. When an abundance of glucose and saturated fat enter the cell, impaired blood flow, hypoxia, inflammation and macrophage infiltration in obese adipose tissue may induce oxidative stress and insulin resistance. Excessive circulating saturated fatty acids ectopically accumulate in insulin-sensitive tissues and impair insulin action. In this context, excessive hepatic lipid accumulation may play a central, pathogenic role in insulin resistance...
December 27, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29286943/integrating-simulation-based-learning-into-nursing-education-programs-hybrid-simulation
#13
Vesile Unver, Tulay Basak, Hatice Ayhan, Fatma Ilknur Cinar, Emine Iyigun, Nuran Tosun, Sevinc Tastan, Gulsah Köse
BACKGROUND: Hybrid simulation can be developed with mannequins of any fidelity and tabletop simulators with a standardized patient to create a complex, high-level learning activity. OBJECTIVE: The aim of this study is to analyze the effects of a hybrid simulation technique used with nursing students in a scenario about the emergency setting. METHODS: This one-group quasi-experimental study was carried out with 39 students in Ankara, Turkey, from October to July 2014...
December 22, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29283101/the-reliability-and-validity-of-dokuz-eyl%C3%A3-l-university-meniere-s-disease-disability-scale
#14
Başak Mutlu, Günay Kırkım, Serpil Mungan Durankaya, Selhan Gürkan, Tahsin Oğuz Başokçu, Enis Alpin Güneri
OBJECTIVE: Ménière's Disease (MD) is a chronic, non-life threatening inner ear disease, with attacks of disabling vertigo, progressive hearing loss, and tinnitus as the major symptoms. All three symptoms, separately or in combination, cause great distress and have a considerable impact on the quality of life of the patients. The aims of this study were to develop a disease-specific quality of life survey for patients with MD and to analyze the relationships between the audiovestibular findings and the survey...
December 14, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29280993/response-to-comments-on-double-blind-comparison-of-ultrasonic-and-conventional-osteotomy-in-terms-of-early-postoperative-edema-and-ecchymosis
#15
A Emre Ilhan, Betul Cengiz, Basak Caypinar Eser
No abstract text is available yet for this article.
December 21, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29280246/rich-club-and-reward-network-connectivity-as-endophenotypes-for-alcohol-dependence-a-diffusion-tensor-imaging-study
#16
Nabi Zorlu, Necip Çapraz, Esra Oztekin, Başak Bagci, Maria A Di Biase, Andrew Zalesky, Fazıl Gelal, Emre Bora, Ercan Durmaz, Lütfullah Beşiroğlu, Aybala Sarıçiçek
We aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol use disorder (AUD) and unaffected siblings, relative to healthy comparison individuals. Diffusion-weighted magnetic resonance imaging scans were acquired from 18 patients with AUD, 15 unaffected siblings of AUD patients and 15 healthy controls. Structural networks were examined using network-based statistic and connectomic analysis. Connectomic analysis showed a significant ordered difference in normalized rich club organization (AUD < Siblings < Controls)...
December 27, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29278447/early-initiated-feeding-versus-early-reached-target-enteral-nutrition-in-critically-ill-children-an-observational-study-in-paediatric-intensive-care-units-in-turkey
#17
Soyhan Baǧci, Elif Keleş, Feyza Girgin, Dinçer R Yıldızdaş, Özden Ö Horoz, Nilüfer Yalındağ, Murat Tanyıldız, Benan Bayrakçi, Gökhan Kalkan, Başak N Akyıldız, Alper Köker, Tolga Köroğlu, Ayşe B Anıl, Neslihan Zengin, Ener Ç Dinleyici, Eylem Kıral, Oğuz Dursun, Süleyman Tolga Yavuz, Peter Bartmann, Andreas Müller
AIM: Although early enteral nutrition (EN) is strongly associated with lower mortality in critically ill children, there is no consensus on the definition of early EN. The aim of this study was to evaluate our current practice supplying EN and to identify factors that affect both the initiation of feeding within 24 h after paediatric intensive care unit (PICU) admission and the adequate supply of EN in the first 48 h after PICU admission in critically ill children. METHODS: We conducted a prospective, multicentre, observational study in nine PICUs in Turkey...
December 26, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29259917/a-novel-suturing-technique-for-filtering-glaucoma-surgery-the-accordion-suture
#18
REVIEW
Mehmet Baykara, Basak Can Ermerak, Huri Sabur, Selim Genc
AIM: To present a novel scleral flap suturing technique for filtering glaucoma surgery in order to control high postoperative intraocular pressure (IOP). METHODS: Description of 'the accordion suture' technique for mitomycin C augmented trabeculectomy. In cases of postoperative high IOP, pulling the loop of the suture helps to lift up the scleral flap by an even pressure on both edges. By means of this technique, the scleral flap opens up in an "accordion" manner, thus preventing flap obstruction and providing adequate aqueous flow...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29249797/factors-affecting-liver-regeneration-in-living-donors-after-hepatectomy
#19
Cem Ibis, Yavor Asenov, Melih Akin, Ibrahim F Azamat, Nukhet Sivrikoz, Basak Gurtekin
BACKGROUND The safety of living liver donors is the paramount priority of liver transplantation surgeons. The liver has an effective regeneration capacity. The regeneration rate of the liver remnant in living liver donors provides much information useful in liver surgery. The outcome of the remnant liver after hepatectomy can be affected by many different perioperative factors. MATERIAL AND METHODS A total of 46 patients were enrolled in the study. Retrospective clinical data, including preoperative and postoperative early and late computed tomography liver volumetry measurements, estimated resection volumes, resected liver weights, and postoperative laboratory values, were statistically evaluated according to the liver resection type...
December 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29235362/reconsidering-the-causality-of-tia1-mutations-in-als
#20
Rick A Van Der Spek, Wouter Van Rheenen, Sara L Pulit, Kevin P Kenna, Nicola Ticozzi, Maarten Kooyman, Russell L McLaughlin, Matthieu Moisse, Kristel R Van Eijk, Joke J F A Van Vugt, Peter Andersen, A Nazli Basak, Ian Blair, Mamede De Carvalho, Adriano Chio, Philippe Corcia, Phillipe Couratier, Vivian E Drory, Jonathan D Glass, Orla Hardiman, Jesús S Mora, Karen E Morrison, Miguel Mitne-Neto, Wim Robberecht, Pamela J Shaw, Monica P Panadés, Philip Van Damme, Vincenzo Silani, Marc Gotkine, Markus Weber, Michael A Van Es, John E Landers, Ammar Al-Chalabi, Leonard H Van Den Berg, Jan H Veldink
No abstract text is available yet for this article.
December 13, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
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