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https://www.readbyqxmd.com/read/28227671/imquant-an-image-based-fluorescence-reader-for-quantitative-lateral-flow-immunoassays
#1
Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam, Jayaraj Joseph, Kaushik Basak Chowdhury
Fluorescence immunoassays (FIA) have strong potential in enabling rapid quantitative immunological testing at point of care. Existing state of the art instruments employ laser scanning of FIA test kits, which require the use of electromechanical systems, making the instrument bulky, heavy and less reliable in the long term. There is a growing need for an extremely compact and reliable, motion-free, automated reader for accurate quantification of immunoassays. Here, we present ImQuant, an image based FIA reader with integrated monochromatic excitation source, optical filtering and real time image capture, assisted with an intuitive graphical user interface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222673/editorial-descriptor-spaces-for-qsar-delving-into-the-history-of-the-expanding-frontier
#2
EDITORIAL
Subhash C Basak, Rama K Mishra
No abstract text is available yet for this article.
2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/28209192/learning-from-2523-trauma-deaths-in-india-opportunities-to-prevent-in-hospital-deaths
#3
Nobhojit Roy, Deepa Kizhakke Veetil, Monty Uttam Khajanchi, Vineet Kumar, Harris Solomon, Jyoti Kamble, Debojit Basak, Göran Tomson, Johan von Schreeb
BACKGROUND: A systematic analysis of trauma deaths is a step towards trauma quality improvement in Indian hospitals. This study estimates the magnitude of preventable trauma deaths in five Indian hospitals, and uses a peer-review process to identify opportunities for improvement (OFI) in trauma care delivery. METHODS: All trauma deaths that occurred within 30 days of hospitalization in five urban university hospitals in India were retrospectively abstracted for demography, mechanism of injury, transfer status, injury description by clinical, investigation and operative findings...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28207884/correction-a-european-spectrum-of-pharmacogenomic-biomarkers-implications-for-clinical-pharmacogenomics
#4
Clint Mizzi, Eleni Dalabira, Judit Kumuthini, Nduna Dzimiri, Istvan Balogh, Nazli Başak, Ruwen Böhm, Joseph Borg, Paola Borgiani, Nada Bozina, Henrike Bruckmueller, Beata Burzynska, Angel Carracedo, Ingolf Cascorbi, Constantinos Deltas, Vita Dolzan, Anthony Fenech, Godfrey Grech, Vytautas Kasiulevicius, Ľudevít Kádaši, Vaidutis Kučinskas, Elza Khusnutdinova, Yiannis L Loukas, Milan Macek, Halyna Makukh, Ron Mathijssen, Konstantinos Mitropoulos, Christina Mitropoulou, Giuseppe Novelli, Ioanna Papantoni, Sonja Pavlovic, Giuseppe Saglio, Jadranka Sertić, Maja Stojiljkovic, Andrew P Stubbs, Alessio Squassina, Maria Torres, Marek Turnovec, Ron H van Schaik, Konstantinos Voskarides, Salma M Wakil, Anneke Werk, Maria Del Zompo, Branka Zukic, Theodora Katsila, Ming Ta Michael Lee, Alison Motsinger-Rief, Howard L Mc Leod, Peter J van der Spek, George P Patrinos
[This corrects the article DOI: 10.1371/journal.pone.0162866.].
2017: PloS One
https://www.readbyqxmd.com/read/28198526/tongue-and-lingual-salivary-glands-of-the-canary-sem-and-histochemical-study
#5
Feyza Basak, Sukru Hakan Atalgin, Emine Umran Bozkurt
In this study, morphological characteristics of the canary tongue were examined macroscopically and histologically besides using scanning electron microscopy (SEM). Furthermore, histochemical features of the lingual salivary glands of the canary were also examined. The results suggest that the tongue of the canary has an equilateral quadrangle shape is sloped towards the apex on its dorsal surface; where its sides are bounded by tall epithelial extensions. Additionally, histological examination showed that salivary glands were only present on the body of the tongue and there were no taste buds...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28189064/oral-application-of-carbon-nanofibers-in-rats-increases-blood-concentration-of-il6-and-il10-and-decreases-locomotor-activity
#6
Nina Vitalievna Sayapina, Tatyana Anantolievna Batalova, Alexander Alexandrovich Sergievich, Mikhail Anatolievich Shtarberg, Eugeny Alexandrovich Borodin, Pavel Pavlovich Khoroshikh, Vladimir Victorovich Chaika, Vladimir Valerievich Kodintsev, Alexey Anatolievich Vedyagin, Ilya Vladimirovich Mishakov, Antonis Vakis, Petra Henrich-Noack, Aristidis M Tsatsakis, Ayse Basak Engin, Kirill Golokhvast
Carbon nanofibers (CNF) are versatile nanomaterials that are widely used in various fields of science and technology. As a consequence, animals as well as humans may be exposed to such compounds via different routes. We hypothesized that oral intake of CNF will lead to an inflammatory reaction and consequently induce behavioral impairments. To address this issue, rats were fed with 500mg/kgCNF for 14days and their locomotor activity, emotional status and cognition were quantified by testing the animals in an open field set-up, elevated plus maze and in the universal problem solving box which provides information about motivation and cognition...
January 24, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28187885/automated-characterization-and-counting-of-ki-67-protein-for-breast-cancer-prognosis-a-quantitative-immunohistochemistry-approach
#7
Tushar Mungle, Suman Tewary, Indu Arun, Bijan Basak, Sanjit Agarwal, Rosina Ahmed, Sanjoy Chatterjee, Asok Kumar Maity, Chandan Chakraborty
Ki-67 protein expression plays an important role in predicting the proliferative status of tumour cells and deciding the future course of therapy in breast cancer. Immunohistochemical (IHC) determination of Ki-67 score or labelling index, by estimating the fraction of Ki67 positively stained tumour cells, is the most widely practiced method to assess tumour proliferation (Dowsett et al. 2011). Accurate manual counting of these cells (specifically nuclei) due to complex and dense distribution of cells, therefore, becomes critical and presents a major challenge to pathologists...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28179125/exercise-increases-leptin-levels-correlated-with-igf-1-in-hippocampus-and-prefrontal-cortex-of-adolescent-male-and-female-rats
#8
Nazan Uysal, Sinem Agilkaya, Ali Riza Sisman, Ulas Mehmet Camsari, Celal Gencoglu, Ayfer Dayi, Ilkay Aksu, Basak Baykara, Sultan Cingoz, Muge Kiray
It is known that regular aerobic exercise has positive effects on hippocampus and prefrontal cortex. We have previously have been able to demonstrate that aerobic exercise increased IGF-1 in hippocampus. Leptin, which is associated with cognitive functions, is also involved in fat metabolism and stimulates energy consumption. While it is known that leptin stimulates IGF-1 production in hepatocytes, little known is on the link between IGF-1 and leptin in brain during aerobic exercise. In this study, we investigated the effects of regular aerobic exercise on leptin, leptin receptor expression levels in hippocampus and prefrontal cortex...
February 4, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28168835/pregabalin-treatment-of-three-cases-with-brachioradial-pruritus
#9
Güldehan Atış, Başak Bilir Kaya
Brachioradial pruritus (BRP) is a rare type of chronic pruritus that usually localized at the dorsolateral part of the forearms. Itching, burning, or pain are common symptoms at the involved areas. The etiological factors are still unknown but sun exposure and/or cervical spine lesions seem to be trigerring or precipiting factors. Neuropathogenic mechanism plays role in etiopathogenesis of BRP, therefore, antiepileptic drugs such as gabapentin, oxcarbazepine. and pregabalin are suggested medications for BRP...
February 6, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28166448/treatment-of-gingival-melanin-hyperpigmentation-with-er-cr-ysgg-laser-short-term-follow-up-of-patient
#10
Basak Kusakcİ Seker
The increasing melanin hyperpigmentation of dark skinned individuals was related to the high activity of melanocytes. Also smoking reactive the melanocytes to produce melanin. Gingival depigmentation is a periodontal plastic procedure which has been carried out by various techniques. A healthy 36-years-old female patient complained about unaesthetic gingiva and she had smoked over 17 years. Hyperpigmentation of gingiva observed on the labial surface of both maxilla and mandibula. Er,Cr:YSGG laser was used for depigmentation with wavelength of 2780nm, frequency of 20hz, and pulse energy between 0-300 Mj...
February 6, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28163998/bilateral-cystic-adrenal-neuroblastoma-with-cystic-liver-metastasis
#11
Mine Aslan, Deniz Alis, Ayse Ucar Kalyoncu, Hatice Arioz Habibi, Gul Nihal Ozdemir, Basak Koc, Ibrahim Adaletli
Bilateral congenital cystic adrenal neuroblastoma (NB) with cystic liver metastasis is a very rare condition and only few cases have been reported in the literature. Herein we report a case of a congenital bilateral cystic adrenal NB with cystic liver metastasis and briefly discuss characteristic imaging features of cystic NB.
January 2017: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/28161638/6-phosphofructo-2-kinase-fructose-2-6-bisphosphatase-3-is-required-for-transforming-growth-factor-%C3%AE-1-enhanced-invasion-of-panc1-cells-in%C3%A2-vitro
#12
Abdullah Yalcin, Tugba H Solakoglu, Selahattin C Ozcan, Saime Guzel, Sabire Peker, Serap Celikler, Basak D Balaban, Elif Sevinc, Yunus Gurpinar, Jason A Chesney
Transforming growth factor β1 (TGFβ1) is a well-established inducer of the epithelial-mesenchymal transition (EMT) that is essential for the acquisition of malignant properties, such as invasion, in tumor cells. Although recent studies suggest that the EMT in tumor cells is associated with reprogramming of energy metabolism and TGFβ1 has been shown to stimulate glycolysis in multiple primary cell lines, little is known about TGFβ1's effect on glycolysis and glycolytic regulators in transformed cells. Given the known regulatory role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 (PFKFB3) in glycolysis and association of glycolytic activity with malignant features such as invasion, we sought to investigate whether TGFβ1 regulates PFKFB3 expression and if PFKFB3 is involved in the TGFβ1-mediated increase in the invasive ability of the Panc1 cell cline-a well-established model of TGFβ1-initiated EMT...
March 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28160639/pharmacoinformatics-study-of-piperolactam-a-from-piper-betle-root-as-new-lead-for-non-steroidal-anti-fertility-drug-development
#13
Sk Abdul Amin, Plaban Bhattacharya, Souvik Basak, Shovanlal Gayen, Ashis Nandy, Achintya Saha
Fertility control is a burning problem all over the world to regulate population overflow and maintain ecological balance. This study is an in-silico approach to explore a non-steroidal lead as contraceptive agent in order to avoid several contraindications generated by steroidal analogues. Piperolactam A, an aristolactam isolated from Piper betle Linn. showed binding affinity towards estrogen and progesterone receptor as -8.9 and -9.0Kcal/mol (inhibition constant Ki=0.294μM and 0.249μM) respectively which is even larger than that of reported antagonists such as Rohitukine and OrgC (binding affinity -8...
January 11, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28158500/fsh-stimulation-promotes-progesterone-synthesis-and-output-from-human-granulosa-cells-without-luteinization
#14
Ozgur Oktem, Nazli Akin, Gamze Bildik, Kayhan Yakin, Ebru Alper, Basak Balaban, Bulent Urman
No abstract text is available yet for this article.
February 2, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28158215/in-silico-analyses-and-global-transcriptional-profiling-reveal-novel-putative-targets-for-pea3-transcription-factor-related-to-its-function-in-neurons
#15
Başak Kandemir, Ugur Dag, Burcu Bakir Gungor, İlknur Melis Durasi, Burcu Erdogan, Eray Sahin, Ugur Sezerman, Isil Aksan Kurnaz
Pea3 transcription factor belongs to the PEA3 subfamily within the ETS domain transcription factor superfamily, and has been largely studied in relation to its role in breast cancer metastasis. Nonetheless, Pea3 plays a role not only in breast tumor, but also in other tissues with branching morphogenesis, including kidneys, blood vasculature, bronchi and the developing nervous system. Identification of Pea3 target promoters in these systems are important for a thorough understanding of how Pea3 functions. Present study particularly focuses on the identification of novel neuronal targets of Pea3 in a combinatorial approach, through curation, computational analysis and microarray studies in a neuronal model system, SH-SY5Y neuroblastoma cells...
2017: PloS One
https://www.readbyqxmd.com/read/28157495/map-k-ing-the-path-to-stem-cell-quiescence-and-the-elusive-enteroendocrine-cell
#16
Simon J Leedham
The existence and interaction of proliferating and quiescent intestinal stem cells have been debated since their discovery in the 1970s. In this issue of Cell Stem Cell, using murine intestinal organoids, Basak et al. (2017) induce stem cell quiescence by selective inhibition of EGF/MAPK signaling and define culture conditions that direct differentiation to the enteroendocrine lineage.
February 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28152784/breast-cancer-patient-functional-status-and-comorbidities-and-their-impact-on-treatment-aggressiveness-a-population-based-study
#17
Ramsankar Basak, Ronald C Chen
: 306 Background: The ASCO Choosing Wisely Campaign and other published guidelines recommend avoidance of aggressive treatments in early-stage cancer patients with limited life expectancy. However, patients with more advanced cancers are likely to benefit from aggressive treatment. The population-based SEER-MHOS (Medicare Health Outcomes Survey) provides unique data to allow assessment of aggressiveness of cancer treatment by cancer stage and patient frailty. METHODS: MHOS includes patient-reported functional deficits in a sample of Medicare beneficiaries, and has been linked with SEER data which provide diagnostic and treatment data...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28140609/imaging-concordant-benign-mri-guided-vacuum-assisted-breast-biopsy-may-not-warrant-mri-follow-up
#18
Monica L Huang, Megan Speer, Basak E Dogan, Gaiane M Rauch, Rosalind P Candelaria, Beatriz E Adrada, Kenneth R Hess, Wei T Yang
OBJECTIVE: The follow-up of breast lesions with imaging-concordant benign histopathology results on MRI-guided vacuum-assisted biopsy (VAB) is not currently standardized. We determined the false omission rate of breast MRI-guided VAB with benign histopathology (negative results) to assess whether breast MRI follow-up is needed. MATERIALS AND METHODS: The medical records of patients who underwent 9-gauge breast MRI-guided VAB during 2007-2012 were reviewed retrospectively...
January 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28114840/flecainide-as-first-line-treatment-for-fetal-supraventricular-tachycardia
#19
Ali Ekiz, Basak Kaya, Helen Bornaun, Deniz Kanber Acar, Muhittin Eftal Avci, Aysegul Bestel, Gokhan Yildirim
OBJECTIVE: The aim of this study was to evaluate utilization, efficacy and side effects of flecainide treatment as first-line agent in patients with fetal supraventricular tachycardia (SVT). METHOD: This retrospective review was conducted on 23 consecutive fetal tachyarrhythmia cases that met inclusion criteria. If the treatment was necessary, flecainide was used as first-line treatment in all cases. RESULT: Among the study group, there were 21 (91...
January 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28108469/blood-rna-biomarkers-in-prodromal-park4-and-rem-sleep-behavior-disorder-show-role-of-complexin-1-loss-for-risk-of-parkinson-s-disease
#20
Suna Lahut, Suzana Gispert, Özgür Ömür, Candan Depboylu, Kay Seidel, Jorge Antolio Domínguez-Bautista, Nadine Brehm, Hülya Tireli, Karl Hackmann, Caroline Pirkevi, Barbara Leube, Vincent Ries, Kerstin Reim, Nils Brose, Wilfred F den Dunnen, Madrid Johnson, Zsuzsanna Wolf, Marc Schindewolf, Wiebke Schrempf, Kathrin Reetz, Peter Young, David Vadasz, Achilleas S Frangakis, Evelin Schröck, Helmuth Steinmetz, Marina Jendrach, Udo Rüb, Ayşe Nazlı Başak, Wolfgang Oertel, Georg Auburger
Parkinson's disease (PD) is a frequent neurodegenerative process at old age. Accumulation and aggregation of the lipid-binding SNARE complex component alpha-synuclein (SNCA) underlies this vulnerability and defines stages of disease progression. Determinants of SNCA levels and mechanisms of SNCA neurotoxicity are intensely investigated. In view of physiological SNCA roles in blood to modulate vesicle release, we studied blood samples from a new large pedigree with SNCA gene duplication (PARK4 mutation), to identify effects of SNCA gain-of-function as potential disease biomarkers...
January 20, 2017: Disease Models & Mechanisms
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