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https://www.readbyqxmd.com/read/28646905/mechanistic-understanding-of-nanoparticles-interactions-with-extracellular-matrix-the-cell-and-immune-system
#1
REVIEW
Ayse Basak Engin, Dragana Nikitovic, Monica Neagu, Petra Henrich-Noack, Anca Oana Docea, Mikhail I Shtilman, Kirill Golokhvast, Aristidis M Tsatsakis
Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. The ECM provides essential physical scaffolding for the cellular constituents, as well as contributes to crucial biochemical signaling. Importantly, ECM is an indispensable part of all biological barriers and substantially modulates the interchange of the nanotechnology products through these barriers. The interactions of the ECM with nanoparticles (NPs) depend on the morphological characteristics of intercellular matrix and on the physical characteristics of the NPs and may be either deleterious or beneficial...
June 24, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28646790/the-effects-of-individual-biological-rhythm-differences-on-sleep-quality-daytime-sleepiness-and-dissociative-experiences
#2
Yavuz Selvi, Ali Kandeger, Murat Boysan, Nursel Akbaba, Ayca A Sayin, Emine Tekinarslan, Basak O Koc, Omer F Uygur, Vedat Sar
Individuals who differ markedly by sleep chronotype, i.e., morning-type or evening-type also differ on a number of psychological, behavioral, and biological variables. Among several other psychological functions, dissociation may also lead to disruption and alteration of consciousness, which may facilitate dream-like experiences. Our study was aimed at an inquiry into the effects of individual biological rhythm differences on sleep quality and daytime sleepiness in conjunction with dissociative experiences...
June 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28644714/genome-mining-in-silico-validation-and-phase-selection-of-a-novel-aldo-keto-reductase-from-candida-glabratea-for-biotransformation
#3
Souvik Basak, Nanda Gopal Sahoo, Angayar K Pavanasam
Previously, we published cloning, over-expression, characterization and subsequent exploitation of a carbonyl reductase (cr) gene, belonging to general family aldo-keto reductase from Candida glabrata CBS138 to convert keto ester (COBE) to a chiral alcohol (ethyl-4-chloro-3-hydroxybutanoate or CHBE). Exploiting global transcription factor CRP, rDNA and transporter engineering, we have improved batch production of CHBE by trinomial bioengineering. Herein, we present the exploration of cr gene in Candida glabrata CBS138 through genome miningapproach, in silico validation of its activity and selection of its biocatalytic phase...
June 23, 2017: Bioengineered
https://www.readbyqxmd.com/read/28643760/validation-of-microsatellite-instability-histology-scores-with-bethesda-guidelines-in-hereditary-nonpolyposis-colorectal-cancer
#4
Mustafa Kaya, Fatih Basak, Abdullah Sisik, Mustafa Hasbahceci, Gurhan Bas, Orhan Alimoglu, Cumhur Selçuk Topal, Gozde Kir
AIMS: Hereditary nonpolyposis colorectal cancer (HNPCC) is a subgroup of colorectal cancer (CRC) which should be differentiated because of the high risk for additional cancers and risk evaluation for other family members, especially for CRC. It is not practical to perform genetic testing for all CRC patients; therefore, various prediction modalities, for example, Bethesda guideline (BG) were studied in the literature. We aimed to assess the association of microsatellite instability (MSI), histology scores, and BG for predicting HNPCC risk...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28642231/secondhand-smoke-exposure-among-community-dwelling-adult-cancer-survivors-in-the-united-states-1999-2012
#5
Oladimeji Akinboro, Odunayo Olorunfemi, Prasanta Basak, Elizabeth Phillips, Daniel Pomerantz, Bernard Bernhardt, Rasim Gucalp, Stephen Jesmajian, Jamie S Ostroff
Background: Little is known about the prevalence of secondhand smoke exposure (SHSe) among cancer survivors. We sought to determine the prevalence, trends, and correlates of SHSe among nonsmoking adult cancer survivors in the United States.Methods: Interview and serum cotinine data for nonsmoking adults, age 20 years and older, with a history of cancer (N = 686) were obtained from consecutive two-year cross-sectional cycles of the National Health and Nutrition Examination Survey from 1999 to 2012. SHSe was defined as serum cotinine 0...
June 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28642190/complications-associated-with-surgically-assisted-rapid-palatal-expansion-without-pterygomaxillary-separation
#6
Sirmahan Cakarer, Basak Keskin, S Cemil Isler, Erol Cansiz, Aysenur Uzun, Cengizhan Keskin
INTRODUCTION: The purpose of this retrospective clinical study was to evaluate the surgical complications associated with the surgically assisted rapid palatal expansion (SARPE) which not involve pterygomaxillary separation (PMS). PATIENTS AND METHODS: A total of 40 (25 female, 15 male) skeletally mature patients who had the diagnosis of maxillary transverse maxillary deficiency (TMD) were treated surgically under local or general anesthesia. The mean follow-up time was 6 months...
June 19, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28633193/trictide-a-tricellulin-derived-peptide-to-overcome-cellular-barriers
#7
Jimmi Cording, Basak Arslan, Christian Staat, Sophie Dithmer, Susanne M Krug, Anneliese Krüger, Philipp Berndt, Ramona Günther, Lars Winkler, Ingolf E Blasig, Reiner F Haseloff
The majority of tight junction (TJ) proteins restrict the paracellular permeation of solutes via their extracellular loops (ECLs). Tricellulin tightens tricellular TJs (tTJs) and regulates bicellular TJ (bTJ) proteins. We demonstrate that the addition of recombinantly produced extracellular loop 2 (ECL2) of tricellulin opens cellular barriers. The peptidomimetic trictide, a synthetic peptide derived from tricellulin ECL2, increases the passage of ions, as well as of small and larger molecules up to 10 kDa, between 16 and 30 h after application to human epithelial colorectal adenocarcinoma cell line 2...
June 20, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28631808/fabrication-of-%C3%AE-cyclodextrin-mediated-single-bimolecular-inclusion-complex-characterization-molecular-docking-in-vitro-release-and-bioavailability-studies-for-gefitinib-and-simvastatin-conjugate
#8
Souvik Basak, Sandip Mondal, Suddhasattya Dey, Plaban Bhattacharya, Achintya Saha, Vinay Deep Punetha, Ali Abbas, Nanda Gopal Sahoo
OBJECTIVES: Introduction of multiple molecules in a single inclusion complex, albeit cheaper, lacks conclusive attempts in earlier drug delivery reports. This manuscript emphasizes simultaneous incorporation of two anticancer drugs, gefitinib (G) and simvastatin (S), in a single molecule of β-cyclodextrin for the first time to achieve effective drug delivery. METHODS: The inclusion complex (GSBCD) was prepared by cosolvent evaporation technique using β-cyclodextrin (BCD) as carrier...
June 20, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28630785/assessment-of-corneal-densitometry-in-rheumatoid-arthritis-patients
#9
Mustafa Alpaslan Anayol, Başak Bostancı, Mehmet Ali Şekeroğlu, Mert Şimşek, Süleyman Günaydın, Pelin Yılmazbaş
OBJECTIVES: To evaluate corneal densitometry and anterior segment parameters of rheumatoid arthritis (RA) patients and compare these results with those of age-matched healthy control subjects. MATERIALS AND METHODS: Anterior segment parameters and corneal densitometry of patients with RA and healthy control subjects were assessed by Scheimpflug corneal topography. For densitometry analysis, the 12-mm diameter area of the cornea was subdivided into four concentric radial zones and anterior, central, and posterior layers based on corneal depth...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28626029/a-homozygous-founder-mutation-in-trappc6b-associates-with-a-neurodevelopmental-disorder-characterised-by-microcephaly-epilepsy-and-autistic-features
#10
Isaac Marin-Valencia, Gaia Novarino, Anide Johansen, Basak Rosti, Mahmoud Y Issa, Damir Musaev, Gifty Bhat, Eric Scott, Jennifer L Silhavy, Valentina Stanley, Rasim O Rosti, Jeremy W Gleeson, Farhad B Imam, Maha S Zaki, Joseph G Gleeson
BACKGROUND: Transport protein particle (TRAPP) is a multisubunit complex that regulates membrane trafficking through the Golgi apparatus. The clinical phenotype associated with mutations in various TRAPP subunits has allowed elucidation of their functions in specific tissues. The role of some subunits in human disease, however, has not been fully established, and their functions remain uncertain. OBJECTIVE: We aimed to expand the range of neurodevelopmental disorders associated with mutations in TRAPP subunits by exome sequencing of consanguineous families...
June 16, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28624995/how-does-it-feel-to-be-a-pathology-resident-results-of-a-survey-on-experiences-and-job-satisfaction-during-pathology-residency
#11
Burcin Pehlivanoglu, Hur Hassoy, Catarina Calle, Amelie Dendooven, ILKe Nalbantoglu, Lidiya Reshchikova, Gulen Gul, Basak Doganavsargil
Residents' career choices and professional motivation can be affected from perception of their role and recognition within a medical team as well as their educational and workplace experiences. To evaluate pathology trainees' perceptions of their pathology residency, we conducted a 42-item survey via a web-based link questioning respondents' personal and institutional background, workplace, training conditions, and job satisfaction level. For the 208 residents from different European countries who responded, personal expectations in terms of quality of life (53%) and scientific excitement (52%) were the most common reasons why they chose and enjoy pathology...
June 17, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28620819/cellular-growth-and-tube-formation-of-htr8-svneo-trophoblast-effects-of-exogenously-added-fatty-acid-binding-protein-4-and-its-inhibitor
#12
Sanjay Basak, Arnab Sarkar, Santosh Mathapati, Asim K Duttaroy
Adequate placental angiogenesis is critical for the establishment of the placental circulation and thus for normal feto-placental growth and development. Fatty acid-binding protein-4 (FABP4) plays a pro-angiogenic role in endothelial cells; however, very little information is available in placental first trimester trophoblast cells. Here we report that exogenously added FABP4 (exo-FABP4) stimulated tube formation (as a measure of in vitro angiogenesis) in HTR8/SVneo trophoblastic cells. HTR-8/SVneo cells were incubated in the presence of exogenously added FABP4 at different concentrations and time points...
June 15, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28618744/comparative-analysis-of-selected-cagpai-genes-and-different-vaca-genotypes-in-iranian-and-turkish-h-pylori-positive-patients-suffering-from-gastric-adenocarcinoma-and-active-chronic-gastritis
#13
Ali Bahadori, Mohammad Hossein Somi, Figen Doran, Amirtaher Eftekharsadat, Suna Kizilyildirim, Mahsa Esmaeillou, Maryam Yaasi, Başak Bedir, Fatih Köksal
BACKGROUND/AIM: Helicobacter pylori is a pathogen that colonizes a majority of the world's population. Genetic diversity within the virulence genes of bacteria such as cagPAI and vacA may have a modified effect on the pathogenic potential of the bacteria. This study aimed to investigate which genes can be suggested as potentially related virulence factors for H. pylori-associated active chronic gastritis and stomach adenocarcinoma in the northwest of Iran and south of Turkey. MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded stomach biopsy tissue samples were obtained from Iranian and Turkish patients from selected geographical regions...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28616613/comparison-of-the-airway-access-skills-of-prehospital-staff-in-moving-and-stationary-ambulance-simulation-a-randomized-crossover-study
#14
Onur Karaca, Basak Bayram, Nese Colak Oray, Asli Acerer, Zeynep Sofuoglu
OBJECTIVES: We aimed to compare the procedural success and intervention durations regarding various airway access skills in moving and stationary ambulance simulations. MATERIAL AND METHODS: An ambulance simulator was used to simulate the moving ambulance environment, and a standard manikin was used for airway simulation. The study included 38 paramedics and paramedic students. In stationary and moving environments, a classical endotracheal intubation with a stylet, an intubation with a gum elastic bougie (GEB), a laryngeal mask airway (LMA), and a laryngeal tube (LT) were applied randomly...
June 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28614092/poloxamer-p85-increases-anticancer-activity-of-schiff-base-against-prostate-cancer-in-vitro-and-in-vivo
#15
Selami Demirci, Ayşegül Doğan, Neşe Başak Türkmen, Dilek Telci, Ahmet B Çağlayan, Mustafa Ç Beker, Ertuğrul Kiliç, Ferda Özkan, Bülent Dede, Fikrettin Şahin
Prostate cancer is the second most common cancer among men and the leading cause of death after lung cancer. Development of hormone-refractory disease is a crucial step for prostate cancer progression for which an effective treatment option is currently unavailable. Therefore, there is a need for new agents that can efficiently target cancer cells, decrease tumor growth, and thereby extend the survival of patients in late-stage castration-resistant prostate cancer. In the current study, a novel heterodinuclear copper(II)Mn(II) Schiff base complex combined with P85 was used to evaluate anticancer activity against prostate cancer in vitro and in vivo...
June 13, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28612918/morphology-of-the-atrioventricular-valves-and-related-intraventricular-structures-in-the-wild-pig-sus-scrofa
#16
Sevinç Ateş, Emine Karakurum, Lutfi Takcı, Feyza Başak, İbrahim Kürtül
Morphology of the atrioventricular valves and the intraventricular related structures were observed and the findings were compared broadly to the literature, in the 7 hearts of the wild pigs (Sus scrofa) by applying macroscopic and microscopic techniques. In all hearts examinated, the tricuspid and mitral valves were precise, composing three and two cusps resepectively. The papillary muscles observed in mammalian heart in general were found in both the ventricles, additionaly there were small unnamed papillary muscles in the left ventricle of the three samples...
June 14, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28590790/the-effect-of-ascorbic-acid-vitamin-c-on-transepithelial-corneal-cross-linking-in-rabbits
#17
Mustafa Koc, Basak Bostanci, Ozlem Ozbas Demirel, Feyza Genc, Kemal Tekin, Yaran Koban, Aylin Sepici Dincel, Murat Sen, Pelin Yilmazbas
PURPOSE: To evaluate the effects of ascorbic acid (vitamin C), the main antioxidant agent in the cornea on transepithelial corneal cross-linking (CXL) where the main mechanism is oxidation. METHODS: Twenty eyes of 20 rabbits were divided into 3 groups: Group 1 (7 eyes) had transepithelial corneal CXL after being fed with normal diet; Group 2 (7 eyes) had corneal CXL after once-daily subcutaneous injections of 200 mg of ascorbic acid in addition to normal diet; and the control group (6 eyes) was fed with normal diet but did not have corneal CXL performed...
June 7, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28589640/self-assembly-of-t-butyloxycarbonyl-protected-dipeptide-methyl-esters-composed-of-leucine-isoleucine-and-valine-into-highly-organized-structures-from-alcohol-and-aqueous-alcohol-mixtures
#18
Chivukula Subbalakshmi, Pratyay Basak, Ramakrishnan Nagaraj
Short peptides composed of phenylalanine and sequences derived from amyloidogenic peptides have the ability to self-assemble to form nanostructures including hydrogels. The self-assembly of peptides composed of only hydrophobic amino acids and aliphatic protecting groups have not been investigated in detail. We have examined various aspects of nanostructures formed by N-terminal t-butyloxycarbonyl-protected aliphatic dipeptide methyl esters dissolved in various solvents. Scanning electron microscopic images indicate that depending on the sequence, position of the amino acid and solvent of dissolution, the peptides self-assemble into superstructures such as nanotubes and needles particularly from aqueous mixtures of organic solvents...
June 7, 2017: Biopolymers
https://www.readbyqxmd.com/read/28589183/the-clinicopathologic-characteristics-and-prognostic-factors-of-gastroesophageal-junction-tumors-according-to-siewert-classification
#19
Bala Başak Öven Ustaalioğlu, Metin Tilki, Ali Sürmelioğlu, Ahmet Bilici, Can Gönen, Recep Ustaalioğlu, Özlem Balvan, Mehmet Aliustaoğlu
OBJECTIVE: The treatment of gastroesophageal junction tumors remains controversial due to confusion on whether they should be considered as primary esophageal or as gastric tumors. The incidence of these tumors with poor prognosis has increased, thus creating scientific interest on gastroesophageal cancers. Esophagogastric cancers are classified according to their location by Siewert, and the treatment of each type varies. We evaluated the prognostic factors and differences in clinicopathologic factors of patients with gastroesophageal junction tumor, who have been treated and followed-up in our clinics...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28585673/can-hypo-hypernatremic-conditions-be-a-factor-for-na-ion-channel-kinetics-model-study
#20
Murat Ayaz, Hakan Karabagli, Sirma Basak Yanardag
AIM: Dysnatremic cases are frequently faced in clinical practice and the macroscopic effects of it and its consequences are well known, but microscopic effects of it are not well defined, this research tries to reveal the effects of dysnatremia at the cellular level. MATERIAL AND METHODS: By using an action potential simulation, the effects of the extracellular sodium concentration on the sodium ion channel kinetics are studied. The experimental sets are chosen to mimic hypo/hypernatremic conditions and in both cases degree of the severity is varied...
April 21, 2017: Turkish Neurosurgery
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