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https://www.readbyqxmd.com/read/29157427/long-eyebrow-hair-causing-corneal-ulcer
#1
Samar K Basak, Soham Basak, Utpal Sarkar
No abstract text is available yet for this article.
December 2017: Ophthalmology
https://www.readbyqxmd.com/read/29156867/cross-cultural-adaptation-and-psychometric-assessment-of-the-turkish-version-of-the-vulnerability-to-abuse-screening-scale
#2
Güler Duru Aşiret, Gülcan Bağcıvan, Münevver Özcan, Beste Başak Eröksüz, Nalan Akbayrak, Nuran Akdemir
Background/aim: The aim of this study was to evaluate the reliability and validity of the Turkish version of the Vulnerability to Abuse Screening Scale (VASS). Materials and methods: This was a methodological study. The sample included 140 elderly individuals. Data were collected by using a questionnaire form, the VASS, and the Geriatric Depression Scale (GDS). The Cronbach alpha value was calculated and test?retest reliability was tested for the reliability analyses. Results: The Cronbach alpha value calculated for the VASS (12 items) was 0...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29156860/decreased-oxidative-stress-may-contribute-to-the-disease-process-in-placenta-accreta
#3
Efser Öztaş, Sibel Özler, Merve Ergin, Özcan Erel, Başak Gümüş Güler, Ali Turhan Çağlar, Aykan Yücel, Dilek Uygur, Nuri Danışman
Background/aim: The main aim of this study was to investigate serum total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and arylesterase levels in pregnant women with placenta accreta and to compare those with age-matched healthy pregnant women. Materials and methods: A total of 27 pregnant women who had clinically and pathologically proven placenta accreta and 30 age- and BMI- matched healthy pregnant women were enrolled in this case control study. Maternal serum TOS, TAS, OSI, and arylesterase levels were evaluated using logistic regression analysis to determine if there was an association with abnormal placental invasion or not...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29155101/type-i-ifn-related-netosis-in-ataxia-telangiectasia-and-artemis-deficiency
#4
Ersin Gul, Esra Hazar Sayar, Bilgi Gungor, Fehime Kara Eroglu, Naz Surucu, Sevgi Keles, Sukru Nail Guner, Sıddıka Fındık, Esin Alpdündar, Ihsan Cihan Ayanoglu, Basak Kayaoglu, Busra Nur Geçkin, Hatice Asena Sanli, Tamer Kahraman, Cengiz Yakicier, Meltem Muftuoglu, Berna Oguz, Deniz Nazire Cagdas Ayvaz, Ihsan Gursel, Seza Ozen, Ismail Reisli, Mayda Gursel
BACKGROUND: Pathological inflammatory syndromes of unknown etiology are commonly observed in Ataxia telangiectasia (AT) and Artemis deficiency. Similar inflammatory manifestations also exist in STING-associated vasculopathy in infancy (SAVI) patients. OBJECTIVE: To test the hypothesis that the inflammation associated manifestations observed in AT and Artemis deficient patients stem from increased type I IFN signature leading to neutrophil mediated pathological damage...
November 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29151319/patients-attitudes-and-knowledge-about-drug-use-a-survey-in-turkish-family-healthcare-centres-and-state-hospitals
#5
Ahmet Akıcı, Salih Mollahaliloğlu, Başak Dönertaş, Şenay Özgülcü, Ali Alkan, Nesrin Filiz Başaran
Background/aim: Irrational drug use is a common problem. This study aimed to evaluate patients' knowledge and habits concerning drug use, and compare them in terms of some sociodemographic characteristics. Materials and methods: A face-to-face questionnaire was given to outpatients from family healthcare centres (FHCs) and state hospitals (SHs) in 12 provinces in Turkey during May 2010. A total of 4470 patients (FHCs: 2209; SHs: 2261) responded to the questionnaire (response rate: 93.1%). Results: Getting prescriptions without a physical examination was common (second place in FHCs; third place in SHs); 51...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29150544/estimation-of-circulating-drug-metabolite-exposure-in-human-using-in-vitro-data-and-physiologically-based-pharmacokinetic-modelling-example-of-a-high-metabolite-parent-drug-ratio
#6
R Scott Obach, Jian Lin, Emi Kimoto, Sridhar Duvvuri, Timothy Nicholas, Eugene P Kadar, Larry M Tremaine, Aarti Sawant Basak
TBPT ((R)-4-((4-(((4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol), a serotonin-4 receptor partial agonist, is metabolized to two metabolites: an N-dealkylation product (M1) and a cyclized oxazolidine structure (M2). After administration to humans, the exposure to M1 was low and the exposure to M2 was high, relative to the parent drug, despite this being the opposite in vitro. In this study, projection of the plasma metabolite/parent ratios for M1 and M2 was attempted, using in vitro metabolism, binding, and permeability data in static and dynamic PBPK models...
November 17, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29143055/use-of-azidonaphthalimide-carboxylic-acids-as-fluorescent-templates-with-a-built-in-photoreactive-group-and-a-flexible-linker-simplifies-protein-labeling-studies-applications-in-selective-tagging-of-hcaii-and-penicillin-binding-proteins
#7
Monisha Singha, Sayantani Roy, Satya Deo Pandey, Subhendu Sekhar Bag, Prabuddha Bhattacharya, Mainak Das, Anindya S Ghosh, Debashis Ray, Amit Basak
This work describes the synthesis of azidonaphthalimide carboxylic acids which act as fluorescent templates with a built-in photoreactive group and a linker thus simplifying the design of protein labeling agents. These were separately connected to selectivity hands like a sulfonamide and ampicillin for successful labeling/detection of HCAII and PBPs, respectively.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29143006/cooperative-supramolecular-polymerization-of-a-perylene-diimide-derivative-and-its-impact-on-electron-transporting-properties
#8
Dipankar Basak, Deep Sankar Pal, Tsuneaki Sakurai, Satoru Yoneda, Shu Seki, Suhrit Ghosh
H-bonding-promoted supramolecular polymerization of a perylene diimide (PDI) building block and its impact on charge carrier mobility were studied. PDI-1, containing a carboxylic acid group, exhibits H-aggregation in a non-polar solvent decalin while in THF or chloroform it remains in the monomeric form. In contrast, the control molecule PDI-2, containing an ester group does not show aggregation even in decalin, indicating that H-bonding among the carboxylic acid is primarily responsible for H-aggregation, which is further verified by the FT-IR study...
November 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29141604/genome-wide-identification-of-mirnas-and-lncrnas-in-cajanus-cajan
#9
Chandran Nithin, Amal Thomas, Jolly Basak, Ranjit Prasad Bahadur
BACKGROUND: Non-coding RNAs (ncRNAs) are important players in the post transcriptional regulation of gene expression (PTGR). On one hand, microRNAs (miRNAs) are an abundant class of small ncRNAs (~22nt long) that negatively regulate gene expression at the levels of messenger RNAs stability and translation inhibition, on the other hand, long ncRNAs (lncRNAs) are a large and diverse class of transcribed non-protein coding RNA molecules (> 200nt) that play both up-regulatory as well as down-regulatory roles at the transcriptional level...
November 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29141232/foxp1-promotes-embryonic-neural-stem-cell-differentiation-by-repressing-jagged1-expression
#10
Luca Braccioli, Stephin J Vervoort, Youri Adolfs, Cobi J Heijnen, Onur Basak, R Jeroen Pasterkamp, Cora H Nijboer, Paul J Coffer
Mutations in FOXP1 have been linked to neurodevelopmental disorders including intellectual disability and autism; however, the underlying molecular mechanisms remain ill-defined. Here, we demonstrate with RNA and chromatin immunoprecipitation sequencing that FOXP1 directly regulates genes controlling neurogenesis. We show that FOXP1 is expressed in embryonic neural stem cells (NSCs), and modulation of FOXP1 expression affects both neuron and astrocyte differentiation. Using a murine model of cortical development, FOXP1-knockdown in utero was found to reduce NSC differentiation and migration during corticogenesis...
November 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29141065/use-of-isoquercetin-in-the-treatment-of-prurigo-nodularis
#11
Christine M Pennesi, John Neely, Ames G Marks, S Alison Basak
<p>Atopic dermatitis and prurigo nodularis result from complex interactions between the skin, the immune system, and the external environment. The pruritus associated with these conditions greatly impacts patients' quality of life and lacks uniformly effective treatment. A 57-year-old patient presented with severe atopic dermatitis and subsequent prurigo nodularis refractory to numerous standard therapies. The supplement isoquercetin was initiated and he noted significant, sustained reduction in his pruritus after only four weeks...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29133639/comparison-of-seropositivity-of-human-immunodeficiency-virus-hepatitis-b-virus-hepatitis-c-virus-and-syphilis-among-hospital-cornea-retrieval-programme-donors-versus-voluntary-cornea-donors-at-a-large-eye-bank-in-eastern-india
#12
Soham Basak, Samar K Basak, Bani Biswas
PURPOSE: To compare the serology profile of donors from Hospital Cornea Retrieval Programme-donors (HCRP-D) and voluntary cornea donors (VC-D) from a large eye bank in Eastern India. METHODS: This is a retrospective analysis of donor details from January 2011 to December 2016. Donor demographics, cause of death, and serology reports were compiled. Postmortem blood was tested for human immunodeficiency virus 1 and 2 (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and syphilis using government-approved kits as per the National Programme for Control of Blindness Standards of Eye Banking...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29124862/catabolic-task-division-between-two-interchangeable-near-isogenic-subpopulations-co-existing-in-a-herbicide-degrading-bacterial-consortium-consequences-for-the-interspecies-consortium-metabolic-model
#13
Pieter Albers, Cédric Lood, Basak Özturk, Benjamin Horemans, Rob Lavigne, Vera van Noort, René De Mot, Kathleen Marchal, Aminael Sanchez-Rodriguez, Dirk Springael
Variovorax sp. WDL1 mediates hydrolysis of the herbicide linuron into 3,4-dichloroaniline (DCA) and N,O-dimethylhydroxylamine in a tripartite bacterial consortium with Comamonas testosteroni WDL7 and Hyphomicrobium sulfonivorans WDL6. Although strain WDL1 contains the dcaQTA1A2B operon for DCA oxidation, this conversion is mainly performed by WDL7. Phenotypic diversification observed in WDL1 cultures and scrutiny of the WDL1 genome suggest that WDL1 cultures consist of two dedicated subpopulations, i.e., a linuron-hydrolyzing subpopulation (Lin+DCA-) and a DCA-oxidizing subpopulation (Lin-DCA+)...
November 10, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/29123586/long-term-evolution-of-squamous-cell-cancer-in-plummer-vinson-syndrome
#14
Ulaş Aday, Ebubekir Gündeş, Durmuş Ali Çetin, Hüseyin Çiyiltepe, Kayhan Başak, Mustafa Duman
No abstract text is available yet for this article.
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29120289/the-gendered-workplaces-of-women-garment-workers-in-istanbul
#15
Başak Can
Drawing on 20 semi-structured interviews with women garment workers in a low-income neighbourhood of Istanbul, and observations in the ateliers where they worked, this article examines their work experiences in the gendered and sexualised work atmosphere of garment workshops. There are three interrelated levels upon which the gender-related issues emerge in women garment workers' stories. The first set of discourses portrays young female garment workers in highly sexualised terms, and the second concerns the use of kinship vocabulary and avoidance of impersonal work relationships...
October 2017: Reproductive Health Matters
https://www.readbyqxmd.com/read/29114572/an-insight-to-the-binding-of-ellagic-acid-with-human-serum-albumin-using-spectroscopic-and-isothermal-calorimetry-studies
#16
Rudradip Pattanayak, Pijush Basak, Srikanta Sen, Maitree Bhattacharyya
Ellagic acid (EA), a natural polyphenol evidence several pharmacological benefits. The binding profile of EA with human serum albumin (HSA) has been explored and investigated by Isothermal titration calorimetry (ITC), circular dichroism (CD) spectroscopy, time-correlated single-photon counting (TCSPC), absorbance spectroscopy, steady-state fluorescence spectroscopy, and modelling studies. The ITC data analysis revealed the binding Constant (Ka), ΔH, ΔS and ΔG values to be 15.5×10(4)M(-1), -116.2±18.1 Kcal mol(-1), -366 cal mol(-1)K(-1) and -7...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29105486/can-imaging-kinetic-parameters-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-be-valuable-in-predicting-clinicopathological-prognostic-factors-of-invasive-breast-cancer
#17
Cuiyan Wang, Wei Wei, Lumarie Santiago, Gary Whitman, Basak Dogan
Background Intrinsic molecular profiling of breast cancer provides clinically relevant information that helps tailor therapy directed to the specific tumor subtype. We hypothesized that dynamic contrast-enhanced MRI (DCE-MRI) derived quantitative kinetic parameters (CD-QKPs) may help predict molecular tumor profiles non-invasively. Purpose To determine the association between DCE-MRI (CD-QKPs) and breast cancer clinicopathological prognostic factors. Material and Methods Clinicopathological factors in consecutive women with biopsy-confirmed invasive breast cancer who underwent breast DCE-MRI were retrospectively reviewed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29101778/financial-aspects-of-bile-duct-injuries
#18
Ozgkıour Palaz Alı, Abdil Cem Ibis, Basak Gurtekin
BACKGROUND Major bile duct injury is the most worrisome complication of cholecystectomy. There is no detailed data about the incidence or treatment-related costs of bile duct injuries in Turkey. We aimed to determine prevalence and therapeutic costs of patients with major biliary duct injuries managed in our department, and further estimate a projection of these parameters at the national level. MATERIAL AND METHODS All patients admitted due to bile duct injury during cholecystectomy from 2011 to 2014 were included...
November 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29091003/american-college-of-radiology-compliant-short-protocol-breast-mri-for-high-risk-breast-cancer-screening-a-prospective-feasibility-study
#19
Basak E Dogan, Marion E Scoggins, Jong Bum Son, Wei Wei, Rosalind Candelaria, Wei T Yang, Jingfei Ma
OBJECTIVE: The purpose of this study was to assess the feasibility of a short protocol for screening breast MRI that is noninferior to standard-of-care (SOC) MRI in image quality that complies with American College of Radiology accreditation requirements. SUBJECTS AND METHODS: In a prospective feasibility trial, 23 women at high risk underwent both an initial SOC MRI examination that included axial iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) and T1-weighted volume imaging for breast assessment (VIBRANT) dynamic contrast-enhanced sequences and a separate short breast MRI protocol comprising a fast spin-echo (FSE) triple-echo Dixon T2 sequence for T2-weighted imaging and a 3D dual-echo fast spoiled gradient-echo two-point Dixon sequence for dynamic contrast-enhanced imaging from October 1, 2015, through May 2, 2016...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29077212/genetic-variability-human-respiratory-syncytial-virus-subgroups-a-and-b-in-turkey-during-six-successive-epidemic-seasons-2009-2015
#20
Fatma Bayrakdar, Can Naci Kocabaş, Ayşe Başak Altaş, H Gökhan Kavuncuoğlu, Yasemin Coşgun, Emine Dibek Mısırlıoğlu Shahbazi, İhsan Durmaz, Gülay Korukluoğlu, Aykut Özkul
Human respiratory syncytial virus (HRSV) is most important viral respiratory pathogen of acute lower respiratory tract infections in infants and young children worldwide. The circulating pattern and genetic characteristics in the HRSV attachment glycoprotein gene was investigated in Turkey during 6 consecutive seasons from 2009 to 2015. HRSVA was dominant in the all epidemic seasons except 2011-2012 season. Partial sequences of the HVR2 region of the G gene of 479 HRSVA and 135 HRSVB were obtained. Most Turkish strains belonged to NA1, ON1 and BA9, which were the predominant genotypes circulating worldwide...
October 27, 2017: Journal of Medical Virology
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