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https://www.readbyqxmd.com/read/29772694/the-nf-%C3%AE%C2%BAb-activating-pathways-in-multiple-myeloma
#1
REVIEW
Payel Roy, Uday Aditya Sarkar, Soumen Basak
Multiple myeloma(MM), an incurable plasma cell cancer, represents the second most prevalent hematological malignancy. Deregulated activity of the nuclear factor kappaB (NF-κB) family of transcription factors has been implicated in the pathogenesis of multiple myeloma. Tumor microenvironment-derived cytokines and cancer-associated genetic mutations signal through the canonical as well as the non-canonical arms to activate the NF-κB system in myeloma cells. In fact, frequent engagement of both the NF-κB pathways constitutes a distinguishing characteristic of myeloma...
May 16, 2018: Biomedicines
https://www.readbyqxmd.com/read/29772210/in-silico-analysis-seasonal-variation-and-gonadotropic-regulation-of-jag1-and-its-receptor-notch1-in-testis-of-spotted-snakehead-channa-punctatus
#2
Alivia Roy, Reetuparna Basak, Umesh Rai
The present study in seasonally breeding spotted snakehead Channa punctatus, for the first time in nonmammalian vertebrates, demonstrated correlation between reproductive phase-dependent testicular expression of ligand Jag1/receptor Notch1 and spermatogenic events. Testicular transcriptome sequencing data from our earlier study in C. punctatus was used in the present study to select the best transcript for jag1 (cpjag1) and notch1 (cpnotch1). The transcripts cpjag1 and cpnotch1 encoded full-length putative proteins of 1215 (cpJag1) and 2475 (cpNotch1) amino acids, respectively...
May 14, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29765026/hematopoietic-stem-cells-can-differentiate-into-restricted-myeloid-progenitors-before-cell-division-in-mice
#3
Tatyana Grinenko, Anne Eugster, Lars Thielecke, Beáta Ramasz, Anja Krüger, Sevina Dietz, Ingmar Glauche, Alexander Gerbaulet, Malte von Bonin, Onur Basak, Hans Clevers, Triantafyllos Chavakis, Ben Wielockx
Hematopoietic stem cells (HSCs) continuously replenish all blood cell types through a series of differentiation steps and repeated cell divisions that involve the generation of lineage-committed progenitors. However, whether cell division in HSCs precedes differentiation is unclear. To this end, we used an HSC cell-tracing approach and Ki67RFP knock-in mice, in a non-conditioned transplantation model, to assess divisional history, cell cycle progression, and differentiation of adult HSCs. Our results reveal that HSCs are able to differentiate into restricted progenitors, especially common myeloid, megakaryocyte-erythroid and pre-megakaryocyte progenitors, without undergoing cell division and even before entering the S phase of the cell cycle...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29757145/frequency-of-bile-duct-confluence-variations-in-subjects-with-pancreas-divisum-an-analysis-of-mrcp-findings
#4
Ayşegül Gürsoy Çoruh, Başak Gülpınar, Hakan Baş, Ayşe Erden
PURPOSE: We aimed to evaluate the frequency of bile duct branching pattern variations at the hepatic confluence in patients with pancreas divisum (PD). METHODS: A search was performed through the hospital database using the keyword "pancreas divisum" to identify patients. The magnetic resonance cholangiopancreatography (MRCP) images of 137 patients who were diagnosed with PD between August 2011 and November 2016 were retrospectively analyzed for the presence of bile duct variations...
March 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29757034/educational-level-and-job-status-are-the-most-important-factors-affecting-compliance-to-oral-antihistamine-therapy-for-patients-with-chronic-urticaria
#5
Neslihan Akdogan, Pinar Incel-Uysal, Ayşe Oktem, Yildiz Hayran, Basak Yalcin
BACKGROUND: Management of chronic urticaria (CU) is often difficult with oral antihistamines (OAs) despite long-term use. OBJECTIVE: The aim of this study was to determine the extent of medication compliance (MC) and to assess the factors affecting the MC of CU patients toward OA therapy. METHODS: A 43-item questionnaire was administered to 201 adult patients. A compliance score (CS) of 6 points was chosen as a cut-off point. A CS of 0─6 correspond to poor compliance and scores of 6─9, to good compliance...
May 14, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29746438/hemophagocytic-lymphohistiocytosis-associated-with-visceral-leishmaniasis
#6
Nihal Özdemir, Başak Koç, Esra Arslantaş, Işik Odaman Al, Çiğdem Kelleci, Ezgi Pasli Uysalol, Cengiz Bayram, Ali Ayçiçek
This is the report of a 2-year-old boy who presented with fever, cytopenia, and splenomegaly. The patient was diagnosed with hemophagocytic lymphohistiocytosis (HLH) and treated with HLH-2004 protocol. Repeated bone marrow aspiration showed amastigotes on follow-up. In endemic countries, visceral leishmaniasis should be considered in the differential diagnosis to avoid chemotherapy toxicity.
May 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29744655/does-the-acr-ti-rads-scoring-allow-us-to-safely-avoid-unnecessary-thyroid-biopsy-single-center-analysis-in-a-large-cohort
#7
Fatos Dilan Koseoglu Atilla, Basak Ozgen Saydam, Nihat Ali Erarslan, Ayse Gulden Diniz Unlu, Hamiyet Yilmaz Yasar, Muhammet Ozer, Baris Akinci
INTRODUCTION: The American College of Radiology (ACR) has recently proposed a guideline that recommends clinicians to perform thyroid fine-needle aspiration biopsy (FNAB) on the basis of ultrasound features. In this study, we focused on nodules for which no biopsy is recommended by the ACR Thyroid Imaging, Reporting and Data System (TI-RADS) guideline. SUBJECTS AND METHODS: Two-thousand eight-hundred and forty-seven consecutive patients with thyroid nodules who underwent FNAB according to the 2009 American Thyroid Association (ATA) guideline were included...
May 9, 2018: Endocrine
https://www.readbyqxmd.com/read/29743011/procaine-and-saline-have-similar-effects-on-articular-cartilage-and-synovium-in-rat-knee
#8
Aysun Ankay Yilbas, Basak Akca, Berkem Buyukakkus, Elham Bahador Zirh, Dilara Zeybek, Filiz Uzumcugil, Fatma Saricaoglu
BACKGROUND: Intra-articular local anaesthetics are widely used for providing postoperative analgesia and decreasing the need for opioids. Procaine has proven positive effects in carpal tunnel syndrome and chondromalacia patella. However, the effect of procaine on articular cartilage has not yet been studied. The aim of this study was to evaluate the effects of intra-articular procaine injection on the articular cartilage and the synovium. METHODS: Twenty adult Sprague-Dawley rats were enrolled in the study...
May 9, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29742255/circulation-levels-of-acute-phase-proteins-pentraxin-3-and-serum-amyloid-a-in-atherosclerosis-have-correlations-with-periodontal-inflamed-surface-area
#9
Başak Temelli, Zuhal Yetkin Ay, Hasan Basri Savaş, Fatih Aksoy, Duygu Kumbul Doğuç, Ersin Uskun, Ercan Varol
Objectives One of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients. Material and Methods Patients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29739133/increased-neutrophil-lymphocyte-and-platelet-lymphocyte-ratios-in-male-heroin-addicts-a-prospective-controlled-study
#10
Erdinc Cıcek, Başak Demırel, Ismet Esra Cıcek, Aslı Seda Kıraç, Ibrahim Eren
Objective: The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are markers that can determine the presence of systemic inflammatory response. In this study, we examined the NLR and PLR levels in patients with heroin dependence compared to healthy controls. Methods: The study sample included 90 male patients with heroin dependence aged 18 to 45 years and 60 healthy subjects who had similar socio-demographic characteristics as the patient group...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29739099/short-term-effect-of-high-dose-pantoprazol-on-serum-and-urinary-magnesium-levels
#11
Seyit Uyar, Suleyman Dolu, Basak O Yolcular, Hamit Y Ellidag, Mehmet Kok, Feyzi Bostan, Yasin Sahinturk, Ayhan H Cekin
BACKGROUND: Proton pump inhibitor (PPI) induced hypomagnesemia is a completely unexplained issue and cases are still being reported. Long-term use is the main factor, but there are a few articles stating that it may also emerge with short-term use. We aimed to evaluate the changes of serum and urine magnesium levels during shortterm high dose pantoprazol treatment. METHODS: The serum and 24-hour urine magnesium levels of 58 patients were evaluated during the course of 2 days...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29734842/the-beneficial-effects-of-nerolidol-and-hesperidin-on-surgically-induced-endometriosis-in-a-rat-model
#12
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Aslı Cetin, Nese Basak
The objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation...
May 7, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29722904/renal-complications-of-lipodystrophy-a-closer-look-at-the-natural-history-of-kidney-disease
#13
Baris Akinci, Sadiye Mehtat Unlu, Ali Celik, Ilgin Yildirim Simsir, Sait Sen, Banu Nur, Fatma Ela Keskin, Basak Ozgen Saydam, Nilufer Ozdemir Kutbay, Banu Sarer Yurekli, Bekir Ugur Ergur, Melda Sonmez, Tahir Atik, Atakan Arslan, Tevfik Demir, Canan Altay, Ulku Aybuke Tunc, Tugba Arkan, Ramazan Gen, Erdal Eren, Gulcin Akinci, Aslihan Arasli Yilmaz, Habip Bilen, Samim Ozen, Aygul Celtik, Senay Savas Erdeve, Semra Cetinkaya, Huseyin Onay, Sulen Sarioglu, Elif Arioglu Oral
OBJECTIVES: Lipodystrophy syndromes are a group of heterogeneous disorders characterized by adipose tissue loss. Proteinuria is a remarkable finding in previous reports. STUDY DESIGN: In this multi-center study, prospective follow-up data were collected from 103 subjects with non-HIV associated lipodystrophy registered in the Turkish Lipodystrophy Study Group database to study renal complications in treatment naïve patients with lipodystrophy. METHODS: Main outcome measures included ascertainment of chronic kidney disease (CKD) by studying the level of proteinuria and the estimated glomerular filtration rate (eGFR)...
May 3, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29721577/curcumin-protects-heart-tissue-against-irinotecan-induced-damage-in-terms-of-cytokine-level-alterations-oxidative-stress-and-histological-damage-in-rats
#14
Osman Ciftci, Nese Basak Turkmen, Asli Taslıdere
Irinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin (CRC) was determined in terms of antioxidant and anti-inflammatory properties against heart damage, caused by CPT-11, in rats. Rats were divided randomly into four equal groups (Control, CPT-11, CRC, and CPT-11 + CRC). CPT-11 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg-1 was given orally...
May 2, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29720705/recommendations-from-the-european-society-for-blood-and-marrow-transplantation-ebmt-for-a-curriculum-in-hematopoietic-cell-transplantation
#15
Mohamad Mohty, Rafael F Duarte, Jurgen Kuball, Peter Bader, Grzegorz W Basak, Chiara Bonini, Enric Carreras, Christian Chabannon, Carlo Dufour, Andrew Gennery, Arjan Lankester, Francesco Lanza, Per Ljungman, Silvia Montoto, Arnon Nagler, John A Snowden, Jan Styczynski, Anna Sureda, Nicolaus Kröger
Hematopoietic cell transplantation (HCT) is increasingly used worldwide. This treatment approach is complex and requires specific knowledge and training. The European Society for Blood and Marrow Transplantation (EBMT) identified the need for a set of international recommendations for the clinical training of physicians to qualify them as being competent in performing HCT procedures as well as novel cellular immune therapies and taking care of such patients. The goal is to implement an EBMT HCT-focused global curriculum (EBMT-GC) that can serve as a tool for the development of the HCT sub-specialty worldwide...
May 2, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29704247/clinical-and-molecular-characterization-and-response-to-acitretin-in-three-families-with-sj%C3%A3-gren-larsson-syndrome
#16
Seçil Vural, Atay Vural, Fulya Akçimen, Işın S Bağci, Ceren Tunca, Asli Gündoğdu Eken, Thomas Ruzicka, A Nazli Başak
INTRODUCTION: Sjögren-Larsson syndrome (SLS) is a rare congenital disorder characterized by the triad of ichthyosis, spasticity, and mental retardation. Patients are usually referred to dermatology clinics during infancy. As paraplegia becomes the most debilitating symptom of the disease within a few years, ichthyosis, although a major burden for the patient, takes a back seat. Optimum treatment of ichthyosis in these children and the effect of treatment on different aspects such as severity of the ichthyosis, pruritus, or quality of life of the patients' and their caregivers is not well established...
April 27, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29701159/beware-of-external-validation-a-comparative-study-of-several-validation-techniques-used-in-qsar-modelling
#17
Subhabrata Majumdar, Subhash C Basak
BACKGROUND: Proper validation is an important aspect of QSAR modelling. External validation is one of the widely used validation methods in QSAR where the model is built on a subset of the data and validated on the rest of the samples. However, its effectiveness for datasets with a small number of samples but large number of predictors remains suspect. OBJECTIVE: Calculating hundreds or thousands of molecular descriptors using currently available software has become the norm in QSAR research, owing to computational advances in the past few decades...
April 26, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29699594/beneficial-effects-of-curcumin-and-capsaicin-on-cyclophosphamide-induced-premature-ovarian-failure-in-a-rat-model
#18
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak
BACKGROUND: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model...
April 26, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29696655/determination-of-honey-adulteration-with-beet-sugar-and-corn-syrup-using-infrared-spectroscopy-and-genetic-algorithm-based-multivariate-calibration
#19
Başak Başar, Durmuş Özdemir
BACKGROUND: Fourier transform infrared spectroscopy (FTIR) equipped with attenuated total reflectance (ATR) accessory was used to determine honey adulteration. Adulterated honey samples were prepared by adding corn syrup, beet sugar and water as adulterants to the pure honey samples in various amounts. The spectra of adulterated and pure honey samples (n=209) were recorded between 4000 to 600 cm-1 wavenumber range. RESULTS: Genetic algorithm based inverse least squares (GILS) and partial least squares (PLS) methods were used to determine honey content and amount of adulterants...
April 26, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29695768/association-between-single-nucleotide-polymorphisms-and-adverse-events-in-nivolumab-treated-non-small-cell-lung-cancer-patients
#20
Sander Bins, Edwin A Basak, Samira El Bouazzaoui, Stijn L W Koolen, E Oomen-de Hoop, Cor H van der Leest, Astrid A M van der Veldt, Stefan Sleijfer, Reno Debets, Ron H N van Schaik, Joachim G J V Aerts, Ron H J Mathijssen
BACKGROUND: Treatment with PD-1 inhibitors can be hampered by severe auto-immune-related toxicities. Our objective was to identify single-nucleotide polymorphisms (SNPs) in genes previously associated with auto-immunity, which are associated with toxicities in nivolumab-treated NSCLC patients. This was in order to identify patients prone to develop severe toxicities and to gain more insight into the underlying pathobiology. METHODS: We analysed 322 nivolumab-treated patients and assessed the association with toxicities for seven SNPs in four genes, which are considered contributors to PD-1-directed T-cell responses, i...
April 26, 2018: British Journal of Cancer
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