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https://www.readbyqxmd.com/read/27915363/outcomes-following-a-vestibular-rehabilitation-and-aerobic-training-program-to-address-persistent-post-concussion-symptoms
#1
Brian M Moore, Joseph T Adams, Edward Barakatt
PURPOSE: To describe changes in adults with persistent symptoms and disability following a concussion after completing a supervised home exercise vestibular rehabilitation (VR) program combined with aerobic training. METHOD: Participants included 14 consecutive individuals referred for VR within the context of a comprehensive concussion center. Outcome measures were administered at initial evaluation, 3 mos, and 6 mos. Outcome measures included: Rivermead Post-Concussion Questionnaire symptom (RPQ-3) and function (RPQ-13) subcategories, Dizziness Handicap Inventory (DHI), Activities-specific Balance Confidence Scale (ABC), functional gait assessment (FGA), return to work/study (RTW), and return to activity (RTA)...
2016: Journal of Allied Health
https://www.readbyqxmd.com/read/27912080/the-itch-ubiquitin-ligase-is-required-for-kshv-rta-induced-vflip-degradation
#2
Jennifer C Chmura, Kevin Herold, Ayana Ruffin, Trudymae Atuobi, Yetunde Fabiyi, Ashley E Mitchell, Young Bong Choi, Elana S Ehrlich
Expression of Kaposi's sarcoma herpesvirus vFLIP, a potent activator of NFkB signaling, promotes latency. Inhibition of NFkB signaling promotes lytic reactivation. We previously reported that lytic inducer, RTA, inhibits vFLIP induced NFkB signaling by inducing the degradation of vFLIP via the proteasome. Here we report that the cellular ubiquitin ligase, Itch, is required for RTA induced degradation of vFLIP. Expression of either Itch targeting shRNA or a dominant negative mutant of the ubiquitin ligase both increased the stability of vFLIP in the presence of RTA...
November 29, 2016: Virology
https://www.readbyqxmd.com/read/27903650/structural-analysis-of-single-domain-antibodies-bound-to-a-second-neutralizing-hot-spot-on-ricin-toxin-s-enzymatic-subunit
#3
Michael J Rudolph, David J Vance, Michael S Cassidy, Yinghui Rong, Nicholas J Mantis
Ricin toxin is a heterodimer consisting of RTA, a ribosome-inactivating protein, and RTB, a lectin that facilitates receptor-mediated uptake into mammalian cells. In previous studies, we demonstrated that toxin-neutralizing antibodies target four spatially distinct hotspots on RTA, which we refer to as epitope Clusters I-IV. In this report we identified and characterized three single domain camelid antibodies (VHH) against Cluster II. One of these VHHs, V5E1, ranks as one of the most potent ricin-neutralizing antibodies described to date...
November 30, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27900972/failure-to-thrive-and-nephrocalcinosis-due-to-distal-renal-tubular-acidosis-a-rare-presentation-of-pediatric-lupus-nephritis
#4
Madhumita Nandi, Mrinal Kanti Das, Sukanta Nandi
A 9-year-old female child was initially diagnosed of having nephrocalcinosis with distal renal tubular acidosis (dRTA) while investigating for short stature. She later on developed features of nephrotic syndrome (NS) while on treatment for RTA. Investigation for the cause of NS revealed very strong serological evidence in favor of systemic lupus erythematosus (SLE). Histopathological confirmation could not be done due to bilateral severely contracted kidneys. There are a few case reports of dRTA as the presentation of SLE, but nephrocalcinosis with dRTA with subsequent manifestation of SLE has hitherto not been reported in literature...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27889732/distal-renal-tubular-acidosis-associated-with-celiac-disease-and-thyroiditis
#5
Amit Kumar Satapathy, Sapna Mittal, Vandana Jain
BACKGROUND: Association of distal renal tubular acidosis (RTA) with autoimmune diseases is extremely rare in children. CASE CHARACTERISTICS: 12-year-old girl with distal RTA. Despite resolution of acidosis on bicarbonate, she continued to have poor growth and delayed puberty. Investigations revealed autoimmune thyroiditis and celiac disease. OUTCOME: Levothyroxine and gluten-free diet were initiated. Child gained height and weight and had onset of puberty after gluten withdrawal...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27886256/structural-insights-into-the-interaction-of-the-ribosomal-p-stalk-protein-p2-with-a-type-ii-ribosome-inactivating-protein-ricin
#6
Xiaojiao Fan, Yuwei Zhu, Chongyuan Wang, Liwen Niu, Maikun Teng, Xu Li
Ricin is a type II ribosome-inactivating protein (RIP) that depurinates A(4324) at the sarcin-ricin loop of 28 S ribosomal RNA (rRNA), thus inactivating the ribosome by preventing elongation factors from binding to the GTPase activation centre. Recent studies have disclosed that the conserved C-terminal domain (CTD) of eukaryotic ribosomal P stalk proteins is involved in the process that RIPs target ribosome. However, the details of the molecular interaction between ricin and P stalk proteins remain unknown...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27869953/profile-of-work-related-road-traffic-accident-victims-recorded-by-sentinel-health-units-in-pernambuco-brazil-2012-2014
#7
Caroline Cordeiro Souto, Flávia Karina Wanderley Reis, Raphaella Patrícia Torres Bertolini, Rosimeiry Santos de Melo Almeida Lins, Sandra Luzia Barbosa de Souza
OBJECTIVE: to describe the profile of work-related road traffic accident (RTA) victims, reported by Road Traffic Accident Information Sentinel Units in the state of Pernambuco, Brazil, from 2012-2014. METHODS: descriptive study of fatal and non-fatal work-related road traffic accident victims, reported by 21 RTA Information Sentinel Units in Pernambuco. RESULTS: 87.8% of the 10,691 cases reported occurred among males; 69.0% of all records were related to the 20-39 age group; the sectors with most injured workers were Transport (24...
April 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27855219/the-epstein-barr-virus-immunoevasins-bcrf1-and-bplf1-are-expressed-by-a-mechanism-independent-of-the-canonical-late-pre-initiation-complex
#8
Jessica McKenzie, Francesc Lopez-Giraldez, Henri-Jacques Delecluse, Ann Walsh, Ayman El-Guindy
Subversion of host immune surveillance is a crucial step in viral pathogenesis. Epstein-Barr virus (EBV) encodes two immune evasion gene products, BCRF1 (viral IL-10) and BPLF1 (deubiquitinase/deneddylase); both proteins suppress antiviral immune responses during primary infection. The BCRF1 and BPLF1 genes are expressed during the late phase of the lytic cycle, an essential but poorly understood phase of viral gene expression. Several late gene regulators recently identified in beta and gamma herpesviruses form a viral pre-initiation complex for transcription...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27853045/primary-sjogren-s-syndrome-presenting-as-hypokalemic-paralysis-a-case-series
#9
M Goroshi, S Khare, T Jamale, N S Shah
Primary Sjögren's syndrome (pSS) primarily involves exocrine glands, and renal tubular acidosis (RTA) is seen in one-third of the cases. RTA with hypokalemic paralysis as a presenting feature of pSS is described in few case reports in literature. We report 13 cases who presented as hypokalemic paralysis, and on evaluation were diagnosed to be pSS, as per the diagnostic criteria laid by the Sjφgren's International Collaborative Clinical Alliance (2012). All patients were female, with a mean age at presentation being 33...
November 16, 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27851605/1971-a-case-of-hypokalemic-paralysis-caused-by-rta-type-1-resulting-in-osmotic-demyelination-syndrome
#10
Remi Okwechime, Hung-I Liao, Dora Izaguirre-Anariba, Moyna Kapoor, Jesus Lanza, Parvez Mir
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837274/regulation-of-the-viral-life-cycle-by-murine-gammaherpesvirus-68-micrornas
#11
Soowon Kang, Chanoh Jeon, Kyungtaek Im, Moon Jung Song, Hyeyoung Min
γ-Herpesviruses (γHV) such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus are important human pathogens involved in lymphoproliferation and tumorigenesis. Murine gammaherpesvirus 68 (MHV-68, γHV-68) is an effective model for the study of γHV pathogenesis and host-virus interaction because it is closely related to human γHV. Similarly to human γHV, MHV-68 encodes 15 microRNAs (miRNAs). Although their functions remain unknown, they are thought to regulate the viral life cycle or host-virus interactions, similarly to other human γHV...
November 11, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27836977/impaired-telomere-length-and-telomerase-activity-in-peripheral-blood-leukocytes-and-granulosa-cells-in-patients-with-biochemical-primary-ovarian-insufficiency
#12
Xiaofei Xu, Xinxia Chen, Xiruo Zhang, Yixun Liu, Zhao Wang, Peng Wang, Yanzhi Du, Yingying Qin, Zi-Jiang Chen
STUDY QUESTION: Are telomere length and telomerase activity associated with biochemical primary ovarian insufficiency (POI)? SUMMARY ANSWER: Shortened telomere length and diminished telomerase activity were associated with biochemical POI. WHAT IS KNOWN ALREADY: POI is a result of pathological reproductive aging and encompasses occult, biochemical and overt stages. Studies have indicated telomere length as a biomarker for biological aging...
November 11, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27833333/zygomaticomaxillary-complex-fractures-a-review-of-101-cases
#13
Bhasker Yamsani, Rajasekhar Gaddipati, Nandagopal Vura, Sudhir Ramisetti, Rajitha Yamsani
AIM: ZMC fractures are the common facial injuries. The main causes of fractures are trauma due to RTAs, assaults, falls, sports related injuries, and the civilian warfares. This study is to evaluate and review the etiology, incidence, clinical findings and treatment of ZMC fractures. A sincere effort has been put forward in the management of ZMC fractures and their efficacy is evaluated in the larger interest of the patients. MATERIALS AND METHODS: In this study 101 patients having displaced ZMC fractures with insignificant medical history were reviewed to evaluate the versatility of its management, with the main emphasis on post operative stability, restoration of mouth opening, wound healing, esthetic restoration of the prominence of cheek and the complications encountered...
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27823964/michael-acceptor-containing-drugs-are-a-novel-class-of-5-lipoxygenase-inhibitor-targeting-the-surface-cysteines-c416-and-c418
#14
Isabelle V Maucher, Michael Rühl, Simon Bm Kretschmer, Bettina Hofmann, Benjamin Kühn, Jasmin Fettel, Anja Vogel, Karsten T Flügel, Georg Manolikakes, Nadine Hellmuth, Ann-Kathrin Häfner, Vahid Golghalyani, Ann-Katrin Ball, Matthias Piesche, Carmela Matrone, Gerd Geisslinger, Michael J Parnham, Michael Karas, Dieter Steinhilber, Jessica Roos, Thorsten J Maier
Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting with catalytically cysteine residues next to a substrate entry channel. The electrophilicity is derived from an intramolecular Michael acceptor moiety consisting of an electron-withdrawing group in close proximity to a double bond. The potential of the Michael acceptor moiety to interact with functionally relevant cysteines of proteins potentially renders them effective and sustained enzyme activity modulators...
November 4, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27811711/a-taxonomic-revision-of-the-ground-spiders-of-the-genus-apopyllus%C3%A2-araneae-gnaphosidae
#15
Guilherme H F Azevedo, Ricardo Ott, Charles E Griswold, Adalberto J Santos
The American gnaphosid genus Apopyllus Platnick & Shadab is found from southern Mexico to southern Argentina. It can be diagnosed by the complex shape of the RTA, by the membranous tegular extension, the long coiled embolus, the retrolateral incision on the cymbium, the long convoluted copulatory duct extending anteriorly to the copulatory openings and by the presence of paramedian epigynal pockets and of an anterior ridge on the epigynum. The RTA characters are important in species taxonomy but the complex shape and variation of the RTA hampers identification, especially regarding the two most common species: A...
October 25, 2016: Zootaxa
https://www.readbyqxmd.com/read/27807232/structure-of-the-opening-reading-frame-49-protein-encoded-by-kaposi-s-sarcoma-associated-herpesvirus-kshv
#16
Kelly Hew, Saranya Veerappan, Daniel Sim, Tobias Cornvik, Pär Nordlund, Sue-Li Dahlroth
: Herpesviruses alternate between the latent and the lytic life cycle. Switching into the lytic life cycle is important for the herpesviral replication and disease pathogenesis. Activation of a transcription factor replication and transcription activator (RTA) has been demonstrated to govern this switch in KSHV. The protein encoded by open reading frame 49 from KSHV (ORF49KSHV) has been shown to up-regulate lytic replication in KSHV by enhancing the activities of the replication and transcription activator (RTA)...
November 2, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27800467/a-time-series-model-for-assessing-the-trend-and-forecasting-the-road-traffic-accident-mortality
#17
Shahrokh Yousefzadeh-Chabok, Fatemeh Ranjbar-Taklimie, Reza Malekpouri, Alireza Razzaghi
BACKGROUND: Road traffic accident (RTA) is one of the main causes of trauma and known as a growing public health concern worldwide, especially in developing countries. Assessing the trend of fatalities in the past years and forecasting it enables us to make the appropriate planning for prevention and control. OBJECTIVES: This study aimed to assess the trend of RTAs and forecast it in the next years by using time series modeling. MATERIALS AND METHODS: In this historical analytical study, the RTA mortalities in Zanjan Province, Iran, were evaluated during 2007 - 2013...
September 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/27795414/identification-of-novel-kshv-orf50-transcripts-discovery-of-new-rta-isoforms-with-variable-transactivation-potential
#18
Brian S Wakeman, Yoshihiro Izumiya, Samuel H Speck
: Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that has been associated with primary effusion lymphoma, multicentric Castleman's disease, as well as its namesake Kaposi's sarcoma. As a gammaherpesvirus, KSHV is able to acutely replicate, enter latency, and reactivate from this latent state. A key protein involved in both acute replication and reactivation from latency is the replication and transcriptional activator (RTA) encoded by the gene Orf50. RTA is a known transactivator of multiple viral genes allowing for it to control the switch between latency and virus replication...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27780949/alterations-in-acetylation-of-histone-h4-lysine-8-and-trimethylation-of-lysine-20-associated-with-lytic-gene-promoters-during-kaposi-s-sarcoma-associated-herpesvirus-reactivation
#19
Sora Lim, Seho Cha, Jun Hyeong Jang, Dahye Yang, Joonho Choe, Taegun Seo
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with formation of Kaposi's sarcoma, multicentric Castleman's disease and primary effusion lymphoma. Replication and transcription activator (RTA) genes are expressed upon reactivation of KSHV, which displays a biphasic life cycle consisting of latent and lytic replication phases. RTA protein expression results in KSHV genome amplification and successive viral lytic gene expression. Transcriptional activity of viral lytic genes is regulated through epigenetic modifications...
October 25, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27760204/fine-tuning-of-the-kaposi-s-sarcoma-associated-herpesvirus-life-cycle-in-neighboring-cells-through-the-rta-jag1-notch-pathway
#20
Shasha Li, Hao Hu, Zhiheng He, Deguang Liang, Rui Sun, Ke Lan
Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is an oncogenic pathogen that displays latent and lytic life cycles. In KS lesions, infiltrated immune cells, secreted viral and/or cellular cytokines, and hypoxia orchestrate a chronic pro-lytic microenvironment that can promote KSHV reactivation. However, only a small subset of viruses spontaneously undergoes lytic replication in this pro-lytic microenvironment while the majority remains in latency. Here, we show that the expression of the Notch ligand JAG1 is induced by KSHV-encoded replication and transcription activator (RTA) during reactivation...
October 2016: PLoS Pathogens
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