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https://www.readbyqxmd.com/read/29156576/stochastic-integration-h%C3%A2-filter-for-rapid-transfer-alignment-of-ins
#1
Dapeng Zhou, Lei Guo
The performance of an inertial navigation system (INS) operated on a moving base greatly depends on the accuracy of rapid transfer alignment (RTA). However, in practice, the coexistence of large initial attitude errors and uncertain observation noise statistics poses a great challenge for the estimation accuracy of misalignment angles. This study aims to develop a novel robust nonlinear filter, namely the stochastic integration H ∞ filter (SIH ∞ F) for improving both the accuracy and robustness of RTA. In this new nonlinear H ∞ filter, the stochastic spherical-radial integration rule is incorporated with the framework of the derivative-free H ∞ filter for the first time, and the resulting SIH ∞ F simultaneously attenuates the negative effect in estimations caused by significant nonlinearity and large uncertainty...
November 18, 2017: Sensors
https://www.readbyqxmd.com/read/29153449/the-changing-epidemiology-of-open-fractures-in-vehicle-occupants-pedestrians-motorcyclists-and-cyclists
#2
Dennis Winkler, Stuart T Goudie, Charles M Court-Brown
AIMS: To investigate the changing epidemiology of open fractures in vehicle occupants, pedestrians, motorcyclists and cyclists. MATERIALS AND METHODS: Data on all non-spinal open fractures admitted to the Royal Infirmary of Edinburgh after a road traffic accident between 1988 and 2010 were collected and analysed to provide information about the changing epidemiology in different patient groups. Demographic information was collected on all patients with the severity of injury being analysed with the Injury Severity Score (ISS), Musculoskeletal Index (MSI) and the number of open fractures...
November 14, 2017: Injury
https://www.readbyqxmd.com/read/29131980/pedestrians-perception-and-response-towards-vehicles-during-road-crossing-at-nighttime
#3
Venkatesh Balasubramanian, Rahul Bhardwaj
Pedestrian being involved in road traffic accidents (RTA) is about 22% of all road traffic related deaths. In this study, we have estimated the pedestrian's response towards an approaching vehicle and the time taken to correctly recognize it while they crossed the road in dim-light nighttime conditions. This is also extendable to cycles and other low powered vehicles. Thirty volunteers participated in this study. A collection of six videos, which comprised of different vehicle scenarios were shown to each of the participants...
November 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29119967/rhynchophylla-total-alkaloid-rescues-autophagy-decreases-oxidative-stress-and-improves-endothelial-vasodilation-in-spontaneous-hypertensive-rats
#4
Chao Li, Feng Jiang, Yun-Lun Li, Yue-Hua Jiang, Wen-Qing Yang, Jie Sheng, Wen-Juan Xu, Qing-Jun Zhu
Autophagy plays an important role in alleviating oxidative stress and stabilizing atherosclerotic plaques. However, the potential role of autophagy in endothelial vasodilation function has rarely been studied. This study aimed to investigate whether rhynchophylla total alkaloid (RTA) has a positive role in enhancing autophagy through decreasing oxidative stress, and improving endothelial vasodilation. In oxidized low-density lipoprotein (ox-LDL)-treated human umbilical vein endothelial cells (HUVECs), RTA (200 mg/L) significantly suppressed ox-LDL-induced oxidative stress through rescuing autophagy, and decreased cell apoptosis...
November 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29089710/case-report-intestinal-obstruction-as-a-late-presentation-of-perforation-of-the-transverse-colon-following-blunt-abdominal-trauma
#5
José Caballero, Cinthya Alva-Torres, Edwin García
Colonic perforation associated with blunt abdominal trauma is rare. Even more so is the formation of an inflammatory adhesion preventing leakage into the peritoneum. We present a case of the above in which the patient presented 1 month later with intestinal obstruction which required surgical intervention. A 38-year-old male, victim of a road traffic accident (RTA), presented with multiple fractures in his extremities which had to be operated on and was later discharged without complications. He was readmitted 1 month following the trauma with intestinal obstruction...
October 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29084250/kshv-inhibits-stress-granule-formation-by-viral-orf57-blocking-pkr-activation
#6
Nishi R Sharma, Vladimir Majerciak, Michael J Kruhlak, Zhi-Ming Zheng
TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are often associated with the cellular antiviral response. In this report, we provide evidence that Kaposi's sarcoma-associated herpesvirus (KSHV) overcomes the host antiviral response by inhibition of SG formation via a viral lytic protein ORF57. By immunofluorescence analysis, we found that B lymphocytes with KSHV lytic infection are refractory to SG induction. KSHV ORF57, an essential post-transcriptional regulator of viral gene expression and the production of new viral progeny, inhibits SG formation induced experimentally by arsenite and poly I:C, but not by heat stress...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29065899/upper-extremity-open-fractures-in-hospitalized-road-traffic-accident-patients-adult-versus-pediatric-cases
#7
Guy Rubin, Kobi Peleg, Adi Givon, Nimrod Rozen
BACKGROUND: Fractures in pediatrics show epidemiological characteristics which are different from fractures in adults. The objective of this study was to examine the injury profiles of open upper extremity fractures (UEFs) in all modes of injury related to road traffic accidents (RTAs) in adult and pediatric hospitalized patients. METHODS: Data on 103,465 RTA patients between 1997 and 2013 whose records were entered in a centralized country trauma database were reviewed...
October 24, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29062185/a-case-of-renal-tubular-acidosis-with-sjogren-s-syndrome-showing-paradoxical-block-of-pth-due-to-severe-hypomagnesemia
#8
B Vinodh Kumar, M Sivalingam, G Shiva Kumaran, Balambal Balakrishnan
Distal renal tubular acidosis (RTA) manifests either as Complete/Classical form or Incomplete/Latent Form. Distal RTA causes normal anion gap metabolic acidosis and hypokalemia. Interstitial Nephritis is the most frequent renal manifestation of Sjogren's, which presents as Distal RTA in 25-40% of patients with Sjogren's syndrome. Magnesium deficiency is frequently associated with hypokalemia. Although serum calcium is the main physiological control for the secretion of parathyroid hormone (PTH) by the parathyroid, serum magnesium can also exert similar effects...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29051869/case-of-acute-concomitant-rupture-of-anterior-cruciate-ligament-and-patellar-tendon-of-knee-surgical-decision-making-and-outcome
#9
Jithin Orville Lobo, Joe Joseph Cherian, Arnav Sahu
INTRODUCTION: Acute concomitant rupture of both anterior cruciate ligament (ACL) and patellar tendon is a rare injury. The diagnosis of either of the injuries may be missed on clinical examination in the emergency room. A high index of suspicion is necessary when active extension is absent, and necessary investigations like ultrasound or magnetic resonance imaging (MRI) should be done to confirm the diagnosis. There are no fixed treatment protocols in these injuries. The options include immediate repair of patellar tendon with either simultaneous or delayed reconstruction of ACL...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29046307/high-definition-mapping-of-four-spatially-distinct-neutralizing-epitope-clusters-on-rivax-a-candidate-ricin-toxin-subunit-vaccine
#10
Ronald Toth, Siva Krishna Angalakurthi, Greta Van Slyke, David J Vance, John M Hickey, Sangeeta B Joshi, C Russell Middaugh, David B Volkin, David D Weis, Nicholas J Mantis
RiVax is a promising recombinant ricin toxin A subunit (RTA) vaccine antigen that has been shown to be safe and immunogenic in humans and effective at protecting Rhesus macaques against lethal dose aerosolized toxin exposure. We previously used a panel of RTA-specific monoclonal antibodies (mAbs) to demonstrate, by competition ELISA, that RiVax elicits similar serum antibody profiles in both humans and macaques. However, the actual mAb binding sites on RiVax have yet to be defined. In this study, we employed hydrogen exchange-mass spectrometry (HX-MS) to localize the epitopes on RiVax recognized by nine toxin-neutralizing mAbs and one non-neutralizing mAb...
October 18, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/29043869/identifying-the-biomarker-potential-of-telomerase-activity-and-shelterin-complex-molecule-telomeric-repeat-binding-factor-2-terf2-in-multiple-myeloma
#11
Raman Kumar, Rehan Khan, Nidhi Gupta, Tulika Seth, Atul Sharma, Mani Kalaivani, Alpana Sharma
Telomere length (TL) is maintained by telomere capping protein complex called shelterin complex. We studied the possible involvement and biomarker potential of shelterin complex molecules in naive multiple myeloma (MM) patients and controls. TL, relative telomerase activity (RTA), real-time PCR and Western blotting were performed in bonemarrow sample of 70 study subjects (patients = 50; controls = 20). Significantly lowered mean TL, increased RTA and higher mRNA expression of shelterin molecules were observed in patients, while PIN2/TERF1 interacting telomerase inhibitor 1 (PINX1) showed lower mRNA expression...
October 18, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29038626/maxillofacial-injuries-in-women-a-retrospective-study-of-10%C3%A2-years
#12
Sudhir Ramisetty, Rajasekhar Gaddipati, Nandagopal Vura, Satheesh Pokala, Sheetal Kapse
INTRODUCTION: Diversities exists in incidence, etiology and epidemiology of facial fractures among male and female individuals due to various reasons. Many of the epidemiological studies published during the millennium have shown male predilection. This study was carried to evaluate the etiology, patterns and distribution of facial fractures among different age groups in women. MATERIALS AND METHODS: This Retrospective epidemiological study dealt with a total of 302 women with 422 fractures in maxillofacial region during a period of June 1st 2005 to May 31st 2015 at Mamata Dental College and Hospital, Khammam, Telangana, India...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29031233/forensic-and-clinical-significance-of-serum-amylase-lipase-and-gamma-glutamyl-transferase-as-predictors-of-outcome-in-head-injured-patients
#13
Mona Mohamed Abo El-Noor, Naema Mahmoud ElHosary, Hytham Ibrahim Elatrozy, Hussein Mohamed Abou Elgheit, Ahmed Mohamed Elbelkasy, Ahmed Gamal Fath, Ghada Hamed El-Shafy
Head trauma is one of the leading causes of death and disability worldwide. Combined head lesions consist of more than one form of lesions. Biochemical markers of brain injury are used in determining the extent of brain injury and predicting its outcomes. The aim of this study was to investigate the forensic and clinical significance of serum amylase, lipase and gamma glutamyl transferase (GGT) as predictors of the outcome in head injured patients. PATIENTS AND METHODS: Sixty head injured patients were enrolled and subjected to personal history taking, general and local physical examination...
October 4, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29026384/clinical-and-cranial-computed-tomography-scan-findings-in-adults-following-road-traffic-accidents-in-kampala-uganda
#14
Geoffrey Erem, Samuel Bugeza, Elsie Kiguli Malwadde
BACKGROUND: Globally, road traffic accidents are a major cause of death and disability. The developing countries bear a disproportionately large share of the RTAs which account for about 85% of the deaths. Most of these RTAs result in head injury, which globally, most scholars and medical practitioners consider a significant economic, social and medical problem. In Mulago National referral hospital, RTA is the leading cause of surgical admission. OBJECTIVE: To describe the cranial computed tomography (CT) scan findings in adults following RTA in Mulago hospital...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29021300/high-resolution-epitope-positioning-of-a-large-collection-of-neutralizing-and-non-neutralizing-single-domain-antibodies-on-ricin-toxin-s-enzymatic-and-binding-subunits
#15
David J Vance, Jacqueline M Tremblay, Yinghui Rong, Siva Krishna Angalakurthi, David B Volkin, C Russell Middaugh, David D Weis, Charles B Shoemaker, Nicholas J Mantis
We previously produced a heavy chain-only antibody VH domain (VHH)-displayed phage library from two alpacas that had been immunized with ricin toxoid and non-toxic mixtures of ricin's enzymatic (RTA) and binding (RTB) subunits (Vance et al J. Biol. Chem. 288:36538-47. doi: 10.1074/jbc.M113.519207). Initial and subsequent screens of that library by direct ELISA yielded more than two dozen unique RTA- and RTB-specific VHHs, including 10 whose structures were subsequently solved in complex with RTA. To generate a more complete antigenic map of ricin toxin and define the epitopes associated with toxin-neutralizing activity, we subjected the VHH-displayed phage library to additional pannings on both receptor bound and antibody-captured ricin...
October 11, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28978712/full-length-isoforms-of-kshv-lana-accumulate-in-the-cytoplasm-of-cells-undergoing-the-lytic-cycle-of-replication
#16
H Jacques Garrigues, Kellie Howard, Serge Barcy, Minako Ikoma, Ashlee V Moses, Gail H Deutsch, David Wu, Keiji Ueda, Timothy M Rose
The latency-associated nuclear antigen (LANA) of the Kaposi sarcoma herpesvirus (KSHV) performs a variety of functions to establish and maintain KSHV latency. During latency, LANA localizes to discrete punctate spots in the nucleus where it tethers viral episomes to cellular chromatin and interacts with nuclear components to regulate cellular and viral gene expression. Using highly sensitive tyramide signal amplification (TSA), we determined that LANA localizes to the cytoplasm in different cell types undergoing the lytic cycle of replication after de novo primary infection and after spontaneous, TPA-, or ORF50/RTA-induced activation...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28943341/a-causal-framework-for-integrating-contemporary-and-vedic-holism
#17
REVIEW
John Kineman
Whereas the last Century of science was characterized by epistemological uncertainty; the current Century will likely be characterized by ontological complexity (Gorban and Yablonsky, 2013). Advances in Systems Theory by mathematical biologist Robert Rosen suggest an elegant way forward (Rosen, 2013). "R-theory" (Kineman, 2012) is a synthesis of Rosen's theories explaining complexity and life in terms of a meta-model for 'whole' systems (and their fractions) in terms of "5(th)-order holons". Such holons are Rosen modeling relations relating system-dependent processes with their formative contexts via closed cycles of four archetypal (Aristotelian) causes...
September 21, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28943110/therapies-for-mitochondrial-diseases-and-current-clinical-trials
#18
REVIEW
Ayman W El-Hattab, Ana Maria Zarante, Mohammed Almannai, Fernando Scaglia
Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular defects in genes encoding mitochondrial proteins. Despite the advances in molecular and biochemical methodologies leading to better understanding of the etiology and mechanism of these diseases, there are still no satisfactory therapies available for mitochondrial disorders. Treatment for mitochondrial diseases remains largely symptomatic and does not significantly alter the course of the disease...
September 18, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28938025/the-kaposi-s-sarcoma-associated-herpesvirus-kshv-non-structural-membrane-protein-k15-is-required-for-viral-lytic-replication-and-may-represent-a-therapeutic-target
#19
Bizunesh Abere, Tamrat M Mamo, Silke Hartmann, Naira Samarina, Elias Hage, Jessica Rückert, Sven-Kevin Hotop, Guntram Büsche, Thomas F Schulz
Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of the highly vascularized tumor Kaposi's sarcoma (KS), which is characterized by proliferating spindle cells of endothelial origin, extensive neo-angiogenesis and inflammatory infiltrates. The KSHV K15 protein contributes to the angiogenic and invasive properties of KSHV-infected endothelial cells. Here, we asked whether K15 could also play a role in KSHV lytic replication. Deletion of the K15 gene from the viral genome or its depletion by siRNA lead to reduced virus reactivation, as evidenced by the decreased expression levels of KSHV lytic proteins RTA, K-bZIP, ORF 45 and K8...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28924576/deep-learning-in-breast-cancer-risk-assessment-evaluation-of-convolutional-neural-networks-on-a-clinical-dataset-of-full-field-digital-mammograms
#20
Hui Li, Maryellen L Giger, Benjamin Q Huynh, Natalia O Antropova
To evaluate deep learning in the assessment of breast cancer risk in which convolutional neural networks (CNNs) with transfer learning are used to extract parenchymal characteristics directly from full-field digital mammographic (FFDM) images instead of using computerized radiographic texture analysis (RTA), 456 clinical FFDM cases were included: a "high-risk" BRCA1/2 gene-mutation carriers dataset (53 cases), a "high-risk" unilateral cancer patients dataset (75 cases), and a "low-risk dataset" (328 cases)...
October 2017: Journal of Medical Imaging
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