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https://www.readbyqxmd.com/read/28924576/deep-learning-in-breast-cancer-risk-assessment-evaluation-of-convolutional-neural-networks-on-a-clinical-dataset-of-full-field-digital-mammograms
#1
Hui Li, Maryellen L Giger, Benjamin Q Huynh, Natalia O Antropova
To evaluate deep learning in the assessment of breast cancer risk in which convolutional neural networks (CNNs) with transfer learning are used to extract parenchymal characteristics directly from full-field digital mammographic (FFDM) images instead of using computerized radiographic texture analysis (RTA), 456 clinical FFDM cases were included: a "high-risk" BRCA1/2 gene-mutation carriers dataset (53 cases), a "high-risk" unilateral cancer patients dataset (75 cases), and a "low-risk dataset" (328 cases)...
October 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28919776/safety-pharmacokinetics-and-pharmacodynamics-of-oral-omaveloxolone-rta-408-a-synthetic-triterpenoid-in-a-first-in-human-trial-of-patients-with-advanced-solid-tumors
#2
Ben C Creelan, Dmitry I Gabrilovich, Jhanelle E Gray, Charles C Williams, Tawee Tanvetyanon, Eric B Haura, Jeffrey S Weber, Geoffrey T Gibney, Joseph Markowitz, Joel W Proksch, Scott A Reisman, Mark D McKee, Melanie P Chin, Colin J Meyer, Scott J Antonia
BACKGROUND: Omaveloxolone is a semisynthetic oleanane triterpenoid that potently activates Nrf2 with subsequent antioxidant function. We conducted a first-in-human Phase I clinical trial (NCT02029729) with the primary objectives to determine the appropriate dose for Phase II studies, characterize pharmacokinetic and pharmacodynamic parameters, and assess antitumor activity. METHODS: Omaveloxolone was administered orally once daily continuously in a 28-day cycle for patients with stage 4 relapsed/refractory melanoma or non-small cell lung cancer...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28916974/controlling-growth-high-uniformity-indium-selenide-in2se3-nanowires-via-the-rapid-thermal-annealing-process-at-low-temperature
#3
Ya-Chu Hsu, Yu-Chen Hung, Chiu-Yen Wang
High uniformity Au-catalyzed indium selenide (In2Se3) nanowires are grown with the rapid thermal annealing (RTA) treatment via the vapor-liquid-solid (VLS) mechanism. The diameters of Au-catalyzed In2Se3 nanowires could be controlled with varied thicknesses of Au films, and the uniformity of nanowires is improved via a fast pre-annealing rate, 100 °C/s. Comparing with the slower heating rate, 0.1 °C/s, the average diameters and distributions (standard deviation, SD) of In2Se3 nanowires with and without the RTA process are 97...
September 15, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28912999/tacrolimus-aggravated-tube-feeding-syndrome-with-acute-renal-failure-in-a-pediatric-liver-transplant-recipient
#4
R Kula, M Melter, J Kunkel, C Dörfler, S Alikadic, B Knoppke, R Zant
Acute renal failure can be caused by calcineurin inhibitors (CNIs), due to arteriolopathy and altered tubular function. Within this context, we present the case of a 14-month-old liver transplant recipient who suffered an acute polyuric renal failure during a short episode of hypercaloric feeding. In our case, CNI-induced distal RTA led to nephrocalcinosis and therefore to secondary nephrogenic diabetes insipidus. The diet with high renal solute load consequently resulted in an acute polyuric renal failure with severe hypernatremic dehydration...
2017: Case Reports in Transplantation
https://www.readbyqxmd.com/read/28888090/type-3-renal-tubular-acidosis-associated-with-growth-hormone-deficiency
#5
Yin Ping Liew, Timothy A Rogers, Jane L Garb, Holley F Allen, Edward O Reiter, Thomas J Campfield, Vikas R Dharnidharka, Gregory L Braden
BACKGROUND: We identified two boys with type 3 renal tubular acidosis (RTA) and growth hormone deficiency and we sought to differentiate them from children with classic type 1 distal RTA. METHODS: We reviewed all children <6 years of age with RTA referred over a 13-year period and compared the growth response to alkali therapy in these two boys and in 28 children with only type 1 distal RTA. RESULTS: All children with type 1 RTA reached the 5th percentile or higher on CDC growth charts within 2 years of alkali therapy...
September 9, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28885854/phenoxazine-a-privileged-scaffold-for-radical-trapping-antioxidants
#6
Luke A Farmer, Evan A Haidasz, Markus Griesser, Derek A Pratt
Diphenylamines are widely used to protect petroleum-derived products from autoxidation. Their efficacy as radical-trapping antioxidants (RTAs) relies on a balance of fast H-atom transfer kinetics and stability to one electron oxidation by peroxidic species. Both H-atom transfer and one-electron oxidation are enhanced by substitution with electron-donating substituents, such as the S-atom in phenothiazines, another important class of RTA. Herein we report the results of our investigations of the RTA activity of the structurally-related, but essentially ignored, phenoxazines...
September 8, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28853714/anisotropic-lattice-thermal-conductivity-in-three-fold-degeneracy-topological-semimetal-mop-a-first-principles-study
#7
San-Dong Guo
Recently, three-component new fermions in topological semimetal MoP are experimentally observed (\emph{Nature} \textbf{546}, 627 (2017)), which may have potential applications like topological qubits, low-power electronics and spintronics. These are closely related to thermal transport properties of MoP. In this work, the phonon transport of MoP is investigated by solving the linearized phonon Boltzmann equation within the single-mode relaxation time approximation (RTA). The calculated room-temperature lattice thermal conductivity is 18...
August 30, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28851883/manipulating-the-adhesion-of-electroless-nickel-phosphorus-film-on-silicon-wafers-by-silane-compound-modification-and-rapid-thermal-annealing
#8
Chin-Wei Hsu, Wei-Yen Wang, Kuan-Ting Wang, Hou-An Chen, Tzu-Chien Wei
In this study, the effect of 3-2-(2-aminoethylamino) ethylamino propyl trimethoxysilane (ETAS) modification and post rapid thermal annealing (RTA) treatment on the adhesion of electroless plated nickel-phosphorus (ELP Ni-P) film on polyvinyl alcohol-capped palladium nanoclusters (PVA-Pd) catalyzed silicon wafers is systematically investigated. Characterized by pull-off adhesion, atomic force microscopy, X-ray spectroscopy and water contact angle, a time-dependent, three-staged ETAS grafting mechanism including islandish grafting, a self-assembly monolayer (SAM) and multi-layer grafting is proposed and this mechanism is well correlated to the pull-off adhesion of ELP Ni-P film...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851867/a-unique-tolerizing-dendritic-cell-phenotype-induced-by-the-synthetic-triterpenoid-cddo-dfpa-rta-408-is-protective-against-eae
#9
Hsi-Ju Wei, Tej K Pareek, Qi Liu, John J Letterio
Tolerogenic dendritic cells (DCs) have emerged as relevant clinical targets for the treatment of multiple sclerosis and other autoimmune disorders. However, the pathways essential for conferring the tolerizing DC phenotype and optimal methods for their induction remain an intense area of research. Triterpenoids are a class of small molecules with potent immunomodulatory activity linked to activation of Nrf2 target genes, and can also suppress the manifestations of experimental autoimmune encephalomyelitis (EAE)...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28845903/carrier-type-modulation-and-mobility-improvement-of-thin-mote2
#10
Deshun Qu, Xiaochi Liu, Ming Huang, Changmin Lee, Faisal Ahmed, Hyoungsub Kim, Rodney S Ruoff, James Hone, Won Jong Yoo
A systematic modulation of the carrier type in molybdenum ditelluride (MoTe2 ) field-effect transistors (FETs) is described, through rapid thermal annealing (RTA) under a controlled O2 environment (p-type modulation) and benzyl viologen (BV) doping (n-type modulation). Al2 O3 capping is then introduced to improve the carrier mobilities and device stability. MoTe2 is found to be ultrasensitive to O2 at elevated temperatures (250 °C). Charge carriers of MoTe2 flakes annealed via RTA at various vacuum levels are tuned between predominantly pristine n-type ambipolar, symmetric ambipolar, unipolar p-type, and degenerate-like p-type...
August 28, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28845511/removable-thermoplastic-appliances-modified-by-incisal-cuts-show-altered-biomechanical-properties-during-tipping-of-a-maxillary-central-incisor
#11
Phillipp Brockmeyer, Katharina Kramer, Florian Böhrnsen, Rudolf Matthias Gruber, Sarah Batschkus, Tina Rödig, Wolfram Hahn
BACKGROUND: The present study aimed to evaluate the force delivery of removable thermoplastic appliances (RTAs), modified by different sized incisal cuts, during tipping of a maxillary central incisor in palatal and vestibular direction. METHODS: Forty-five RTAs from three different materials (Biolon®, Erkodur®, Ideal Clear®) of the same thickness (1 mm) were used. Analysis was performed on a separated maxillary central incisor which was part of a resin model with a complete dentition...
August 28, 2017: Progress in Orthodontics
https://www.readbyqxmd.com/read/28842101/navicular-stress-fracture-outcomes-in-athletes-analysis-of-62-injuries
#12
Amol Saxena, Shontal A Behan, Dallas L Valerio, Dominick L Frosch
The optimal treatment modalities for navicular stress fractures in athletes is currently unknown for this season-ending injury. The present study evaluated factors that might be significant and affect healing outcomes, specifically focusing on the return to activity (RTA) time and a decreased desired activity (DDA) after treatment in athletes. Such considerations included previous navicular stress fractures, patient demographic data and type of sport, and initiation time of treatment. The data from 59 patients with 62 fractures were prospectively analyzed from May 2005 through July 2016...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28837769/the-potency-of-diarylamine-radical-trapping-antioxidants-as-inhibitors-of-ferroptosis-underscores-the-role-of-autoxidation-in-the-mechanism-of-cell-death
#13
Ron Shah, Kaitlyn Margison, Derek A Pratt
Two aromatic amines (ferrostatin-1 and liproxstatin-1) were recently identified from high-throughput screening efforts to uncover potent inhibitors of ferroptosis, the necrotic-like cell death induced by inhibition of glutathione peroxidase 4 (GPX4), deletion of the corresponding gpx4 gene, or starvation of GPX4 of its reducing co-substrate, glutathione (GSH). We have since demonstrated that these two aromatic amines are highly effective radical-trapping antioxidants (RTAs) in lipid bilayers, suggesting that they subvert ferroptosis by inhibiting lipid peroxidation (autoxidation) and thus, that this process drives the execution of ferroptosis...
August 24, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28835864/hypokalemic-paralysis-due-to-primary-sj%C3%A3-gren-syndrome-case-report-and-review-of-the-literature
#14
A Garza-Alpirez, A C Arana-Guajardo, J A Esquivel-Valerio, M A Villarreal-Alarcón, D A Galarza-Delgado
Tubulointerstitial nephritis (TIN) is the main renal involvement associated with primary Sjögren syndrome (pSS). TIN can manifest as distal renal tubular acidosis (RTA), nephrogenic diabetes insipidus, proximal tubular dysfunction, and others. We present a 31-year-old female with hypokalemic paralysis due to distal RTA (dRTA). She received symptomatic treatment and hydroxychloroquine with a good response. There is insufficient information on whether to perform a kidney biopsy in these patients or not. The evidence suggests that there is an inflammatory background and therefore a potential serious affection to these patients, such as hypokalemic paralysis...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28835496/expression-and-subcellular-localization-of-the-kshv-k15p-protein-during-latency-and-lytic-reactivation-in-primary-effusion-lymphoma-cells
#15
Caitlin G Smith, Himanshu Kharkwal, Duncan W Wilson
The K15P membrane protein of Kaposi's sarcoma-associated herpesvirus (KSHV) interacts with multiple cellular signaling pathways, and is thought to play key roles in KSHV-associated endothelial cell angiogenesis, regulation of B-cell receptor (BCR) signaling and the survival, activation and proliferation of BCR-negative primary effusion lymphoma (PEL) cells. Although full-length K15P is ∼45kDa in size, numerous lower molecular weight forms of the protein exist as a result of differential splicing and poorly characterized post-translational processing...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28835494/zic2-is-essential-for-maintenance-of-latency-and-is-a-target-of-an-immediate-early-protein-during-kshv-lytic-reactivation
#16
Yuanzhi Lyu, Kazushi Nakano, Ryan R Davis, Clifford G Tepper, Mel Campbell, Yoshihiro Izumiya
Bivalent histone modifications are defined as repressive and activating epigenetic marks that simultaneously decorate the same genomic region. The H3K27me3 mark silences gene expression while H3K4me3 mark prevents the region from becoming permanently silenced and prepares the domain for activation when needed. Specific regions of Kaposi's sarcoma-associated herpesvirus (KSHV) latent episomes are "poised" to be activated by the KSHV replication and transcription activator (K-Rta). How KSHV episomes are prepared such that they maintain latent infection and switch to lytic replication by K-Rta remains unclear...
August 23, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28821622/the-replication-and-transcription-activator-of-murine-gammaherpesvirus-68-cooperatively-enhances-cytokine-activated-stat3-mediated-gene-expression
#17
Hui-Chen Chang Foreman, Julie Armstrong, Alexis L Santana, Laurie T Krug, Nancy C Reich
Gammaherpesviruses (γΗVs) have a dynamic strategy for life-time persistence, involving productive infection, latency, and intermittent reactivation. In latency reservoirs, such as B lymphocytes, γΗV exists as a viral episome and expresses few viral genes. Although the ability of γHV to reactivate from latency and re-enter the lytic phase is challenging to investigate and control, it is known that the γΗV replication and transcription activator, RTA, can promote lytic reactivation. In this study, we provide first evidence that RTA of murine γΗV 68 (MHV68) selectively binds and enhances the activity of tyrosine-phosphorylated host STAT3...
August 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28817355/total-training-load-may-explain-similar-strength-gains-and-muscle-hypertrophy-seen-in-aged-rats-submitted-to-resistance-training-and-anabolic-steroids
#18
Walter Krause Neto, Wellington de Assis Silva, Adriano Polican Ciena, Danilo Bocalini, Ricardo Aparecido Baptista Nucci, Carlos Alberto Anaruma, Eliane Florencio Gama
This study aimed to quantify training parameters and analyze the morphological response of aged muscles submitted to resistance training and anabolic steroids. Aged Wistar rats were divided into groups: C - initial control; CF - final control; CAS - control with anabolic steroid, RT - resistance training, and RTA - resistance training with anabolic steroid. Maximum carried load, absolute and relative loads increased significantly in RT and RTA. RTA demonstrated greater relative load than RT. Average total volume, total climbing volume, relative total volume, relative total climbing volume, and mean climbing volume were similar between groups RT and RTA...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28777778/kshv-and-the-role-of-notch-receptor-dysregulation-in-disease-progression
#19
REVIEW
Jennifer L DeCotiis, David M Lukac
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of two human cancers, Kaposi's Sarcoma (KS) and primary effusion lymphoma (PEL), and a lymphoproliferation, Multicentric Castleman's Disease (MCD). Progression to tumor development in KS is dependent upon the reactivation of the virus from its latent state. We, and others, have shown that the Replication and transcriptional activator (Rta) protein is the only viral gene product that is necessary and sufficient for viral reactivation. To induce the reactivation and transcription of viral genes, Rta forms a complex with the cellular DNA binding component of the canonical Notch signaling pathway, recombination signal binding protein for Jk (RBP-Jk)...
August 4, 2017: Pathogens
https://www.readbyqxmd.com/read/28773982/reduced-subthreshold-characteristics-and-flicker-noise-of-an-algaas-ingaas-phemt-using-liquid-phase-deposited-tio%C3%A2-as-a-gate-dielectric
#20
Kai-Yuen Lam, Jung-Sheng Huang, Yong-Jie Zou, Kuan-Wei Lee, Yeong-Her Wang
This study presents the fabrication and improved properties of an AlGaAs/InGaAs metal-oxide-semiconductor pseudomorphic high-electron-mobility transistor (MOS-PHEMT) using liquid phase deposited titanium dioxide (LPD-TiO₂) as a gate dielectric. Sulfur pretreatment and postoxidation rapid thermal annealing (RTA) were consecutively employed before and after the gate dielectric was deposited to fill dangling bonds and therefore release interface trapped charges. Compared with a benchmark PHEMT, the AlGaAs/InGaAs MOS-PHEMT using LPD-TiO₂ exhibited larger gate bias operation, higher breakdown voltage, suppressed subthreshold characteristics, and reduced flicker noise...
October 25, 2016: Materials
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