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Perioperative chemotherapy and gastric cancer

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https://www.readbyqxmd.com/read/29441995/short-term-curative-effect-of-s-1-plus-oxaliplatin-as-perioperative-chemotherapy-for-locally-advanced-gastric-cancer-a-prospective-comparison-study
#1
Qun Zhao, Yong Li, Jian Huang, Liqiao Fan, Bibo Tan, Yuan Tian, Peigang Yang, Zhikai Jiao, Xuefeng Zhao, Zhidong Zhang, Dong Wang, Yu Liu
This research aimed to investigate the efficacy of S-1 plus oxaliplatin (SOX) as perioperative chemotherapy for locally advanced gastric cancer. We enrolled 102 patients with preoperative clinical stage T3-4N×M0 gastric cancer who were then randomly assigned to receive SOX as either perioperative chemotherapy (group A, 50 patients) or postoperative adjuvant chemotherapy (group B, 52 patients). Short-term curative efficacy and adverse effects of perioperative chemotherapy were analyzed. The rates of R0 resection, surgical complications, combined multiple organ resection, overall survival (OS), and disease-free survival (DFS) were compared between the groups...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29439836/hospital-variation-and-the-impact-of-postoperative-complications-on-the-use-of-perioperative-chemo-radio-therapy-in-resectable-gastric-cancer-results-from-the-dutch-upper-gi-cancer-audit
#2
M G Schouwenburg, L A D Busweiler, N Beck, D Henneman, S Amodio, M I van Berge Henegouwen, A Cats, R van Hillegersberg, J W van Sandick, B P L Wijnhoven, M W J Wouters, G A P Nieuwenhuijzen
BACKGROUND: Dutch national guidelines on the diagnosis and treatment of gastric cancer recommend the use of perioperative chemotherapy in patients with resectable gastric cancer. However, adjuvant chemotherapy is often not administered. The aim of this study was to evaluate hospital variation on the probability to receive adjuvant chemotherapy and to identify associated factors with special attention to postoperative complications. METHODS: All patients who received neoadjuvant chemotherapy and underwent an elective surgical resection for stage IB-IVa (M0) gastric adenocarcinoma between 2011 and 2015 were identified from a national database (Dutch Upper GI Cancer Audit)...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29413875/neoadjuvant-chemotherapy-in-advanced-gastric-and-esophago-gastric-cancer-meta-analysis-of-randomized-trials
#3
REVIEW
Federico Coccolini, Matteo Nardi, Giulia Montori, Marco Ceresoli, Andrea Celotti, Stefano Cascinu, Paola Fugazzola, Matteo Tomasoni, Olivier Glehen, Fausto Catena, Yutaka Yonemura, Luca Ansaloni
INTRODUCTION: Even in after curative surgery and adequate linfoadenectomy the survival of advanced gastric cancer (AGC) remains poor. At present some data have been published on the effects of NACT and perioperative chemotherapy on AGC and Esophago-gastric cancer (EGC) but not definitive ones. The present meta-analysis aims to evaluate the effects of neoadjuvant chemotherapy (NACT) on the AGC and EGC. MATERIAL AND METHODS: A systematic review with meta-analysis of randomized controlled trials (RCTs) of NACT + surgery vs...
January 27, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29394782/-laparoscopic-total-gastrectomy-with-pancreatosplenectomy-after-neoadjuvant-chemotherapy-for-advanced-gastric-cancer-with-adjacent-organs-invasion
#4
Atsushi Gakuhara, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Koji Tanaka, Tomoki Makino, Makoto Yamasaki, Kiyokazu Nakajima, Masaki Mori, Yuichiro Doki
A 71-year-old man was diagnosed with locally advanced gastric cancer(cT4b[Panc], N2, M0, cStage III C). He was treated with a triplet neoadjuvant chemotherapy regimen including docetaxel, oxaliplatin and S-1, followed by laparoscopic total gastrectomy with pancreatosplenectomy which achieved R0 resection. He had no pancreatic fistula, leakage and abscess and was transferred to other hospital on POD18 for rehabilitation. Adjuvant chemotherapy wish S-1was started on 7 weeks after surgery. Although multidisciplinary treatment such as perioperative chemotherapy and radical surgery is necessary, careful and precise interpretation of diagnostic image is mandatory for undergoing curative surgery with composite resection laparoscopically...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394583/-conversion-surgery-for-stage-iv-gastric-cancer
#5
Tomoki Konishi, Toshiyuki Kosuga, Daisuke Ichikawa, Shuhei Komatsu, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Tomohiro Arita, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Eigo Otsuji
This study aimed to examine the clinicopathological factors and prognoses of 5 patients with Stage IV gastric cancer(GC) who underwent chemotherapy followed by R0 resection at our institute from 2004 to 2013. Two patients had non-regional lymph node metastases, another 2 patients had peritoneal disseminations, and 1 patient had peritoneal dissemination and non-regional lymph node and left adrenal metastases. All patients underwent R0 resections following 2-6 courses of chemotherapy using multiple anticancer drugs...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29375213/neoadjuvant-chemotherapy-for-gastric-cancer-is-it-a-must-or-a-fake
#6
Rossella Reddavid, Silvia Sofia, Paolo Chiaro, Fabio Colli, Renza Trapani, Laura Esposito, Mario Solej, Maurizio Degiuli
AIM: To investigate the neoadjuvant chemotherapy (NAC) effect on the survival of patients with proper stomach cancer submitted to D2 gastrectomy. METHODS: We proceeded to a review of the literature with PubMed, Embase, ASCO and ESMO meeting abstracts as well as computerized use of the Cochrane Library for randomized controlled trials (RCTs) comparing NAC followed by surgery (NAC + S) with surgery alone (SA) for gastric cancer (GC). The primary outcome was the overall survival rate...
January 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29374746/fibrinogen-levels-are-associated-with-lymph-node-involvement-and-overall-survival-in-gastric-cancer-patients
#7
Július Palaj, Štefan Kečkéš, Vítězslav Marek, Daniel Dyttert, Iveta Waczulíková, Štefan Durdík
BACKGROUND/AIM: Combination of perioperative chemotherapy with gastrectomy with D2 lymphadenectomy improves long-term survival in patients with gastric cancer. The aim of this study was to investigate the predictive value of preoperative levels of CRP, albumin, fibrinogen, neutrophil-to-lymphocyte ratio and routinely used tumor markers (CEA, CA 19-9, CA 72-4) for lymph node involvement. MATERIALS AND METHODS: This retrospective study was conducted in 136 patients who underwent surgery between 2007 and 2015...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29354900/-analysis-of-risk-factor-of-perioperative-complications-in-patients-with-radical-gastrectomy-for-gastric-cancer-and-its-influence-on-prognosis
#8
Junrui Jin, Jingyu Deng, Han Liang, Changyu Sun, Xiaofan Guo, Jiangtao Guo, Huihui Bai, Huifang Liu, Nannan Zhang
OBJECTIVE: To study the risk factor of perioperative complication in gastric cancer patients with radical therapy and its influence on prognosis. METHODS: Clinical, pathological and follow-up data of 1 148 gastric cancer patients undergoing radical gastrectomy at Tianjin Medical University Affiliated Tumor Hospital between January 2009 and August 2011 were retrospectively collected. Pearson 2 test and Logistic regression analysis were used to analyze the risk factor of perioperative complication...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29299362/tumor-response-evaluation-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-adenocarcinoma-a-prospective-multi-center-cohort-study
#9
Pietro Achilli, Paolo De Martini, Marco Ceresoli, Giulio M Mari, Andrea Costanzi, Dario Maggioni, Raffaele Pugliese, Giovanni Ferrari
Background: To verify the prognostic value of the pathologic and radiological tumor response after neoadjuvant chemotherapy in the treatment of locally advanced gastric adenocarcinoma. Methods: A total of 67 patients with locally advanced gastric cancer (clinical ≥ T2 or nodal disease and without evidence of distant metastases) underwent perioperative chemotherapy (ECF or ECX regimen) from December 2009 through June 2015 in two surgical units. Histopathological and radiological response to chemotherapy were evaluated by using tumor regression grade (TRG) (Becker's criteria) and volume change assessed by CT...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#10
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29242018/current-practice-in-cytoreductive-surgery-and-hipec-for-metastatic-peritoneal-disease-spanish-multicentric-survey
#11
Rafael Morales-Soriano, Neus Esteve-Pérez, Juan José Segura-Sampedro, Pedro Cascales-Campos, Pedro Barrios
INTRODUCTION: Radical Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), has been proposed as the current standard of treatment for metastatic peritoneal disease by several tumors. Despite its widely utilization, there seems to be a great variability in their organization, clinical practice, and safety among centers. AIM OF THE STUDY: To obtain updated information on clinical practice in different perioperative areas of the CRS-HIPEC...
February 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29194623/phase-ii-trial-of-preoperative-chemoradiation-plus-perioperative-sox-chemotherapy-in-patients-with-locally-advanced-gastric-cancer
#12
Xiaowen Liu, Guichao Li, Ziwen Long, Jiliang Yin, Xiaodong Zhu, Weiqi Sheng, Dan Huang, Hui Zhu, Zhaozhen Zhang, Hong Cai, Hua Huang, Guangfa Zhao, Ye Zhou, Zhen Zhang, Yanong Wang
BACKGROUND AND PURPOSE: The ideal treatment strategy of patients with locally advanced gastric adenocarcinoma is unclear. The aim of this study is to evaluate the efficacy and feasibility of preoperative chemoradiation in these patients. PATIENTS AND METHODS: All patients underwent laparoscopic exploration or exploratory laparotomy before chemoradiation. Patients received one cycle of S-1 and oxalipatin followed by concurrent radiation and chemotherapy, then underwent another cycle of S-1 and oxalipatin...
November 30, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29177225/the-principles-of-the-surgical-management-of-gastric-cancer
#13
Elroy P Weledji
Surgery is the only curative therapy for gastric cancer but most operable gastric cancer presents in a locally advanced stage characterized by tumor infiltration of the serosa or the presence of regional lymph node metastases. Surgery alone is no longer the standard treatment for locally advanced gastric cancer as the prognosis is markedly improved by perioperative chemotherapy. The decisive factor for optimum treatment is the multidisciplinary team specialized in gastric cancer. However, despite multimodal therapy and adequate surgery only 30% of gastric cancer patients are alive at 3 years...
August 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29143893/the-role-of-systemic-therapy-in-resectable-gastric-and-gastro-oesophageal-junction-cancer
#14
REVIEW
Elizabeth Cartwright, David Cunningham
Approximately 20% of patients with cancer of the stomach or gastro-oesophageal junction (GOJ) present with resectable disease. Long-term outcome after surgery alone in these patients is poor, and a combined treatment approach is the standard of care. The two approaches to managing patients with cancer of the GOJ are perioperative chemotherapy or preoperative chemoradiotherapy. Based upon the most recent evidence, patients treated with a perioperative approach and deemed suitable for a triplet regimen should be considered for pre- and post-operative FLOT (5-fluorouracil [5-FU], leucovorin, oxaliplatin and docetaxel) and those suitable for a doublet regimen should be considered for a fluoropyrimidine/platinum combination such as capecitabine and oxaliplatin...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29127704/does-neoadjuvant-perioperative-vhemotherapy-improve-overall-survival-for-t2n0-gastric-adenocarcinoma
#15
Emmanuel Gabriel, Kristopher Attwood, Sumana Narayanan, Maureen Brady, Steven Nurkin, Steven Hochwald, Moshim Kukar
BACKGROUND: The purpose of this study was to determine whether neoadjuvant and/or perioperative chemotherapy (NAC) has an overall survival (OS) benefit for patients with T2N0 gastric adenocarcinoma. STUDY DESIGN: We performed retrospective analyses using the National Cancer Data Base, 2004-2013. Patients with T2N0 gastric adenocarcinoma were divided into two treatment groups: (1) NAC plus surgery (NA + S) and (2) surgery alone (S). RESULTS: Of 1,704 patients included, 277 (16...
November 11, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29110040/-surgical-strategy-in-multimodal-treatment-of-gastric-and-esophageal-cancer
#16
REVIEW
J Hoeppner
The majority of curatively treatable esophageal and gastric carcinomas are currently diagnosed in a locally advanced stage in Western Europe. The vast majority of patients in Western Europe and the USA are now treated in multimodal treatment protocols. These protocols consist of neoadjuvant chemoradiation or perioperative chemotherapy plus radical surgical resection including lymphadenectomy. Radical esophagectomy and gastrectomy are still the main curative therapeutic step in these  multimodal protocols. The current surgical recommendations and guidelines were, however, based on experience and studies from almost exclusively unimodal treatment of patient groups...
December 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29071366/perioperative-chemotherapy-vs-neoadjuvant-chemoradiation-in%C3%A2-gastroesophageal-junction-adenocarcinoma-a-population-based-evaluation-of-the-munich-cancer-registry
#17
Stefan Münch, Daniel Habermehl, Ayman Agha, Claus Belka, Stephanie E Combs, Renate Eckel, Helmut Friess, Alexander Gerbes, Natascha C Nüssler, Wolfgang Schepp, Roland M Schmid, Wolfgang Schmitt, Gabriele Schubert-Fritschle, Bernhard Weber, Jens Werner, Jutta Engel
BACKGROUND: To date, it remains unclear whether locally advanced adenocarcinoma of the gastroesophageal junction (AEG) should be treated with neoadjuvant chemoradiation (nCRT), analogous to esophageal cancer, or with perioperative chemotherapy (pCT), analogous to gastric cancer. The purpose of this study was to analyze the data of the Munich Cancer Registry (MCR) and to compare pCT and nCRT in AEG patients. PATIENTS AND METHODS: A total of 2,992 AEG patients, treated between 1998 and 2014, were included in the study...
October 25, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29069277/a-novel-pretherapeutic-gene-expression-based-risk-score-for-treatment-guidance-in-gastric-cancer
#18
L Bauer, A Hapfelmeier, S Blank, M Reiche, J Slotta-Huspenina, M Jesinghaus, A Novotny, T Schmidt, B Grosser, M Kohlruss, W Weichert, K Ott, G Keller
Background: Perioperative chemotherapy is an established treatment of advanced gastric cancer patients. Treatment selection is based on clinical staging (cT). We aimed to establish and validate a prognostic score including clinical and molecular factors, to optimize treatment decisions for these patients. Patients and methods: We analyzed 626 carcinomas of the stomach and of the gastro-esophageal junction from two academic centers including primarily resected and pre-/perioperatively treated patients...
January 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28963709/predictors-and-prognostic-implications-of-perioperative-chemotherapy-completion-in-gastric-cancer
#19
Georgios Karagkounis, Malcolm Hart Squires, Marcovalerio Melis, George A Poultsides, David Worhunsky, Linda X Jin, Ryan C Fields, Gaya Spolverato, Timothy M Pawlik, Konstantinos I Votanopoulos, Edward A Levine, Carl Schmidt, Mark Bloomston, Clifford S Cho, Sharon Weber, Antonio Masi, Russell Berman, H Leon Pachter, Charles A Staley, Elliot Newman, Shishir K Maithel, Ioannis Hatzaras
BACKGROUND: Perioperative chemotherapy in gastric cancer is increasingly used since the "MAGIC" trial, while clinical practice data outside of trials remain limited. We sought to evaluate the predictors and prognostic implications of perioperative chemotherapy completion in patients undergoing curative-intent gastrectomy across multiple US institutions. METHODS: Patients who underwent curative-intent resection of gastric adenocarcinoma between 2000 and 2012 in eight institutions of the US Gastric Cancer Collaborative were identified...
December 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28927119/effect-of-glutamine-enriched-nutritional-support-on-intestinal-mucosal-barrier-function-mmp-2-mmp-9-and-immune-function-in-patients-with-advanced-gastric-cancer-during-perioperative-chemotherapy
#20
Juan Wang, Yanfen Li, Yuanling Qi
We studied the effects of glutamine-enriched nutritional support on intestinal mucosal barrier, matrix metalloproteinase (MMP)-2, MMP-9 and immune function during perioperative chemotherapy in patients with advanced gastric cancer. The study was conducted on 94 patients with advanced gastric cancer admitted from April 2015 to March 2016. They were randomly divided into observation and control groups, n=47. Control group was given basic nutritional support whereas glutamine-enriched nutritional support was given to patients in observation group...
September 2017: Oncology Letters
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