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Perioperative chemotherapy and gastric cancer

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https://www.readbyqxmd.com/read/29650363/chemotherapy-versus-chemoradiotherapy-after-surgery-and-preoperative-chemotherapy-for-resectable-gastric-cancer-critics-an-international-open-label-randomised-phase-3-trial
#1
Annemieke Cats, Edwin P M Jansen, Nicole C T van Grieken, Karolina Sikorska, Pehr Lind, Marianne Nordsmark, Elma Meershoek-Klein Kranenbarg, Henk Boot, Anouk K Trip, H A Maurits Swellengrebel, Hanneke W M van Laarhoven, Hein Putter, Johanna W van Sandick, Mark I van Berge Henegouwen, Henk H Hartgrink, Harm van Tinteren, Cornelis J H van de Velde, Marcel Verheij
BACKGROUND: Both perioperative chemotherapy and postoperative chemoradiotherapy improve survival in patients with resectable gastric cancer from Europe and North America. To our knowledge, these treatment strategies have not been investigated in a head to head comparison. We aimed to compare perioperative chemotherapy with preoperative chemotherapy and postoperative chemoradiotherapy in patients with resectable gastric adenocarcinoma. METHODS: In this investigator-initiated, open-label, randomised phase 3 trial, we enrolled patients aged 18 years or older who had stage IB- IVA resectable gastric or gastro-oesophageal adenocarcinoma (as defined by the American Joint Committee on Cancer, sixth edition), with a WHO performance status of 0 or 1, and adequate cardiac, bone marrow, liver, and kidney function...
April 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29629222/survival-benefit-of-perioperative-chemotherapy-in-patients-with-locally-advanced-gastric-cancer-a-propensity-score-matched-analysis
#2
Bang Wool Eom, Sohee Kim, Ja Yeon Kim, Hong Man Yoon, Mi-Jung Kim, Byung-Ho Nam, Young-Woo Kim, Young-Iee Park, Sook Ryun Park, Keun Won Ryu
Purpose: It has been reported that the survival of patients with locally advanced gastric cancer (LAGC) is better in East Asia countries than in developed western countries; however, the prognosis of LAGC remains poor. This study aimed to evaluate the effects of perioperative chemotherapy on the long-term survival of East Asia patients with LAGC. Materials and Methods: From October 2006 through August 2008, 43 patients with LAGC received perioperative S-1 combined with weekly docetaxel in a phase II study (neoadjuvant group)...
March 2018: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29601082/cardiopulmonary-fitness-before-and-after-neoadjuvant-chemotherapy-in-patients-with-oesophagogastric-cancer
#3
M Navidi, A W Phillips, S M Griffin, K E Duffield, A Greystoke, K Sumpter, R C F Sinclair
BACKGROUND: Neoadjuvant chemotherapy may have a detrimental impact on cardiorespiratory reserve. Determination of oxygen uptake at the anaerobic threshold by cardiopulmonary exercise testing (CPET) provides an objective measure of cardiorespiratory reserve. Anaerobic threshold can be used to predict perioperative risk. A low anaerobic threshold is associated with increased morbidity after oesophagogastrectomy. The aim of this study was to establish whether neoadjuvant chemotherapy has an adverse effect on fitness, and whether there is recovery of fitness before surgery for oesophageal and gastric adenocarcinoma...
March 30, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29599362/curative-gastrectomy-with-perioperative-chemotherapy-improves-the-survival-for-unresectable-gastric-cancer
#4
Yasunori Otowa, Satoshi Suzuki, Shingo Kanaji, Hitoshi Harada, Tomoko Tanaka, Masashi Yamamoto, Yoshiko Matsuda, Taro Oshikiri, Tetsu Nakamura, Yoshihiro Kakeji
BACKGROUND/AIM: Although there are a few reports recommending gastrectomy for unresectable gastric cancer (UGC) to improve survival, the advantage of gastrectomy remains unclear. The objective of this study was to assess the meanings of the surgical intervention. PATIENTS AND METHODS: Therapeutic outcomes were retrospectively evaluated in 127 patients with UGC. All patients had chemotherapy and 47 patients underwent gastrectomy. Patients were classified to three groups according to the treatment...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29568650/radical-gastrectomy-still-the-cornerstone-of-curative-treatment-for-gastric-cancer-in-the-perioperative-chemotherapy-era-a-single-institute-experience-over-a-decade
#5
Harsh Kanhere, Raghav Goel, Ben Finlay, Markus Trochsler, Guy Maddern
Background and Objectives: Most gastric cancer patients now undergo perioperative chemotherapy (POCT) based on the MAGIC trial results. POCT consists of neoadjuvant chemotherapy (NACT) as well as postoperative adjuvant chemotherapy. This study assessed the applicability of perioperative chemotherapy and the impact of radical gastrectomy encompassing a detailed lymph-node resection on outcomes of gastric cancer. Methods: Medical and pathology records of all gastric carcinoma resections were reviewed from 2006 onwards...
2018: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29564169/comparison-of-perioperative-chemotherapy-with-adjuvant-chemoradiotherapy-for-resectable-gastric-cancer-findings-from-a-population-based-study
#6
Brice Jabo, Matthew J Selleck, John W Morgan, Sharon S Lum, Khaled A Bahjri, Mayada Aljehani, Carlos A Garberoglio, Mark E Reeves, Jukes P Namm, Naveenraj L Solomon, Fabrizio Luca, Crickett Dyke, Maheswari Senthil
Background: Both perioperative chemotherapy (PC) and adjuvant chemoradiotherapy (CRT) improve survival in resectable gastric cancer; however, these treatments have never been formally compared. Our objective was to evaluate treatment trends and compare survival outcomes for gastric cancer patients treated with surgery and either PC or CRT. Methods: We performed a retrospective population-based cohort study between 2007 through 2013 using California Cancer Registry data...
February 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29503129/surgical-morbidity-and-mortality-after-neoadjuvant-chemotherapy-in-the-critics-gastric-cancer-trial
#7
Y H M Claassen, H H Hartgrink, J L Dikken, W O de Steur, J W van Sandick, N C T van Grieken, A Cats, A K Trip, E P M Jansen, W M Meershoek-Klein Kranenbarg, J P B M Braak, H Putter, M I van Berge Henegouwen, M Verheij, C J H van de Velde
BACKGROUND: In order to determine the optimal combination of perioperative chemotherapy and chemoradiotherapy for Western patients with advanced resectable gastric cancer, the international multicentre CRITICS trial (ChemoRadiotherapy after Induction chemotherapy In Cancer of the Stomach) was initiated. In this trial, patients with resectable gastric cancer were randomised before start of treatment between adjuvant chemotherapy or adjuvant chemoradiotherapy following neoadjuvant chemotherapy plus gastric cancer resection...
February 9, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29501977/perioperative-chemotherapy-with-or-without-epidermal-growth-factor-receptor-blockade-in-unselected-patients-with-locally-advanced-oesophagogastric-adenocarcinoma-randomized-phase-ii-study-with-advanced-biomarker-program-of-the-german-cancer-society-aio-cao
#8
Michael Stahl, Annett Maderer, Florian Lordick, Andre L Mihaljevic, Stefan Kanzler, Thomas Hoehler, Peter Thuss-Patience, Stefan Mönig, Volker Kunzmann, Sebastian Schroll, Andreas Sandermann, Andrea Tannapfel, Hans-Joachim Meyer, Christoph Schuhmacher, Hansjochen Wilke, Markus Moehler
BACKGROUND: Perioperative chemotherapy significantly improves survival in patients with locally advanced oesophagogastric cancer (EGC). However, as approximately 60% of patients will die from their disease, new therapeutic agents such as molecular-targeted drugs are needed. PATIENTS AND METHODS: To evaluate the role of panitumumab with perioperative chemotherapy, previously untreated patients with locally advanced EGC received, in an open-label randomised phase II study (NEOPECX), standard epirubicin, cisplatin, capecitabine (ECX) chemotherapy with or without panitumumab...
April 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29492918/-surgical-treatment-and-prognosis-of-borrmann-type-iiii-gastric-cancer-involving-the-whole-stomach
#9
Ruizeng Dong, Zewei Zhang, Yiming Zhou, Yonghong Hua, Jianmin Guo
OBJECTIVE: To explore the surgical treatment and prognosis of Borrmann type IIII( gastric cancer involving the whole stomach. METHODS: Clinicopathological characteristics and survival data of 223 patients with Borrmann type IIII( gastric cancer involving the whole stomach (defined as the tumor infiltrating 3 regions of the stomach) receiving surgical treatment at the Department of Abdominal Surgery of Zhejiang Cancer Hospital between January 2002 and December 2015 were analyzed retrospectively...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29459017/poor-performance-in-incremental-shuttle-walk-and-cardiopulmonary-exercise-testing-predicts-poor-overall-survival-for-patients-undergoing-esophago-gastric-resection
#10
Jessica Whibley, Christopher J Peters, Laura J Halliday, Asif M Chaudry, William H Allum
INTRODUCTION: Esophageal and gastric cancer have a poor prognosis and surgical intervention is associated with considerable morbidity, highlighting the need for careful preoperative assessment. The Incremental Shuttle Walk Test (ISWT) and Cardiopulmonary exercise testing (CPET) can assess preoperative fitness. This study aims to investigate their correlation with both postoperative respiratory complications and overall survival. PATIENTS AND METHODS: Patients were identified who underwent esophageal or gastric resections for cancer between 2010 and 2014 and had ISWT and/or CPET assessments...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29441995/short-term-curative-effect-of-s-1-plus-oxaliplatin-as-perioperative-chemotherapy-for-locally-advanced-gastric-cancer-a-prospective-comparison-study
#11
Qun Zhao, Yong Li, Jian Huang, Liqiao Fan, Bibo Tan, Yuan Tian, Peigang Yang, Zhikai Jiao, Xuefeng Zhao, Zhidong Zhang, Dong Wang, Yu Liu
This research aimed to investigate the efficacy of S-1 plus oxaliplatin (SOX) as perioperative chemotherapy for locally advanced gastric cancer. We enrolled 102 patients with preoperative clinical stage T3-4N×M0 gastric cancer who were then randomly assigned to receive SOX as either perioperative chemotherapy (group A, 50 patients) or postoperative adjuvant chemotherapy (group B, 52 patients). Short-term curative efficacy and adverse effects of perioperative chemotherapy were analyzed. The rates of R0 resection, surgical complications, combined multiple organ resection, overall survival (OS), and disease-free survival (DFS) were compared between the groups...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29439836/hospital-variation-and-the-impact-of-postoperative-complications-on-the-use-of-perioperative-chemo-radio-therapy-in-resectable-gastric-cancer-results-from-the-dutch-upper-gi-cancer-audit
#12
M G Schouwenburg, L A D Busweiler, N Beck, D Henneman, S Amodio, M I van Berge Henegouwen, A Cats, R van Hillegersberg, J W van Sandick, B P L Wijnhoven, M W J Wouters, G A P Nieuwenhuijzen
BACKGROUND: Dutch national guidelines on the diagnosis and treatment of gastric cancer recommend the use of perioperative chemotherapy in patients with resectable gastric cancer. However, adjuvant chemotherapy is often not administered. The aim of this study was to evaluate hospital variation on the probability to receive adjuvant chemotherapy and to identify associated factors with special attention to postoperative complications. METHODS: All patients who received neoadjuvant chemotherapy and underwent an elective surgical resection for stage IB-IVa (M0) gastric adenocarcinoma between 2011 and 2015 were identified from a national database (Dutch Upper GI Cancer Audit)...
January 12, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29413875/neoadjuvant-chemotherapy-in-advanced-gastric-and-esophago-gastric-cancer-meta-analysis-of-randomized-trials
#13
REVIEW
Federico Coccolini, Matteo Nardi, Giulia Montori, Marco Ceresoli, Andrea Celotti, Stefano Cascinu, Paola Fugazzola, Matteo Tomasoni, Olivier Glehen, Fausto Catena, Yutaka Yonemura, Luca Ansaloni
INTRODUCTION: Even in after curative surgery and adequate linfoadenectomy the survival of advanced gastric cancer (AGC) remains poor. At present some data have been published on the effects of NACT and perioperative chemotherapy on AGC and Esophago-gastric cancer (EGC) but not definitive ones. The present meta-analysis aims to evaluate the effects of neoadjuvant chemotherapy (NACT) on the AGC and EGC. MATERIAL AND METHODS: A systematic review with meta-analysis of randomized controlled trials (RCTs) of NACT + surgery vs...
March 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29394782/-laparoscopic-total-gastrectomy-with-pancreatosplenectomy-after-neoadjuvant-chemotherapy-for-advanced-gastric-cancer-with-adjacent-organs-invasion
#14
Atsushi Gakuhara, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Koji Tanaka, Tomoki Makino, Makoto Yamasaki, Kiyokazu Nakajima, Masaki Mori, Yuichiro Doki
A 71-year-old man was diagnosed with locally advanced gastric cancer(cT4b[Panc], N2, M0, cStage III C). He was treated with a triplet neoadjuvant chemotherapy regimen including docetaxel, oxaliplatin and S-1, followed by laparoscopic total gastrectomy with pancreatosplenectomy which achieved R0 resection. He had no pancreatic fistula, leakage and abscess and was transferred to other hospital on POD18 for rehabilitation. Adjuvant chemotherapy wish S-1was started on 7 weeks after surgery. Although multidisciplinary treatment such as perioperative chemotherapy and radical surgery is necessary, careful and precise interpretation of diagnostic image is mandatory for undergoing curative surgery with composite resection laparoscopically...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394583/-conversion-surgery-for-stage-iv-gastric-cancer
#15
Tomoki Konishi, Toshiyuki Kosuga, Daisuke Ichikawa, Shuhei Komatsu, Kazuma Okamoto, Hirotaka Konishi, Atsushi Shiozaki, Hitoshi Fujiwara, Tomohiro Arita, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Eigo Otsuji
This study aimed to examine the clinicopathological factors and prognoses of 5 patients with Stage IV gastric cancer(GC) who underwent chemotherapy followed by R0 resection at our institute from 2004 to 2013. Two patients had non-regional lymph node metastases, another 2 patients had peritoneal disseminations, and 1 patient had peritoneal dissemination and non-regional lymph node and left adrenal metastases. All patients underwent R0 resections following 2-6 courses of chemotherapy using multiple anticancer drugs...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29375213/neoadjuvant-chemotherapy-for-gastric-cancer-is-it-a-must-or-a-fake
#16
Rossella Reddavid, Silvia Sofia, Paolo Chiaro, Fabio Colli, Renza Trapani, Laura Esposito, Mario Solej, Maurizio Degiuli
AIM: To investigate the neoadjuvant chemotherapy (NAC) effect on the survival of patients with proper stomach cancer submitted to D2 gastrectomy. METHODS: We proceeded to a review of the literature with PubMed, Embase, ASCO and ESMO meeting abstracts as well as computerized use of the Cochrane Library for randomized controlled trials (RCTs) comparing NAC followed by surgery (NAC + S) with surgery alone (SA) for gastric cancer (GC). The primary outcome was the overall survival rate...
January 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29374746/fibrinogen-levels-are-associated-with-lymph-node-involvement-and-overall-survival-in-gastric-cancer-patients
#17
Július Palaj, Štefan Kečkéš, Vítězslav Marek, Daniel Dyttert, Iveta Waczulíková, Štefan Durdík
BACKGROUND/AIM: Combination of perioperative chemotherapy with gastrectomy with D2 lymphadenectomy improves long-term survival in patients with gastric cancer. The aim of this study was to investigate the predictive value of preoperative levels of CRP, albumin, fibrinogen, neutrophil-to-lymphocyte ratio and routinely used tumor markers (CEA, CA 19-9, CA 72-4) for lymph node involvement. MATERIALS AND METHODS: This retrospective study was conducted in 136 patients who underwent surgery between 2007 and 2015...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29354900/-analysis-of-risk-factor-of-perioperative-complications-in-patients-with-radical-gastrectomy-for-gastric-cancer-and-its-influence-on-prognosis
#18
Junrui Jin, Jingyu Deng, Han Liang, Changyu Sun, Xiaofan Guo, Jiangtao Guo, Huihui Bai, Huifang Liu, Nannan Zhang
OBJECTIVE: To study the risk factor of perioperative complication in gastric cancer patients with radical therapy and its influence on prognosis. METHODS: Clinical, pathological and follow-up data of 1 148 gastric cancer patients undergoing radical gastrectomy at Tianjin Medical University Affiliated Tumor Hospital between January 2009 and August 2011 were retrospectively collected. Pearson 2 test and Logistic regression analysis were used to analyze the risk factor of perioperative complication...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29299362/tumor-response-evaluation-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-adenocarcinoma-a-prospective-multi-center-cohort-study
#19
Pietro Achilli, Paolo De Martini, Marco Ceresoli, Giulio M Mari, Andrea Costanzi, Dario Maggioni, Raffaele Pugliese, Giovanni Ferrari
Background: To verify the prognostic value of the pathologic and radiological tumor response after neoadjuvant chemotherapy in the treatment of locally advanced gastric adenocarcinoma. Methods: A total of 67 patients with locally advanced gastric cancer (clinical ≥ T2 or nodal disease and without evidence of distant metastases) underwent perioperative chemotherapy (ECF or ECX regimen) from December 2009 through June 2015 in two surgical units. Histopathological and radiological response to chemotherapy were evaluated by using tumor regression grade (TRG) (Becker's criteria) and volume change assessed by CT...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#20
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
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