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https://read.qxmd.com/read/38056984/the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-after-covid-19-infection-a-case-report
#1
Patricia Aguilera-Fernandez, María Del Carmen Navarro-Saez, Carlos Feijoo-Massó, Enrique Esteve-Valverde, Sonia Calzado Isbert, Tamara Parra Parente
The term "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA) describes a variety of autoimmune conditions triggered by exposure to substances with adjuvant activity. We present the case of a patient with a history of biopolymer infiltration in both glutes, who years later experienced progressive weakness and pain in the lower limbs, myalgias, cramps, and progressive functional impotence following a mild COVID-19 infection. Laboratory test results were not consistent with any autoimmune disease. Physical examination revealed diffuse bilateral subcutaneous nodules...
December 2023: Reumatología clinica
https://read.qxmd.com/read/37845561/palpitation-in-women-with-silicone-breast-implants-association-with-autoantibodies-against-autonomic-nervous-system
#2
JOURNAL ARTICLE
Tal Elroy, Gilad Halpert, Avishai M Tsur, Harald Heidecke, Howard Amital, Yehuda Shoenfeld
We explored a possible association between palpitation manifestation in women with silicone breast implants (SBIs) with circulating level of autoantibodies directed against autonomic nervous system (ANS) receptors. The study was conducted in 93 women with SBIs who arrived to our clinic with diverse symptoms thought to be associated with their implants. Titers of 11 various autoantibodies were measured in the sera of women with SBIs who experienced palpitations (Palpitations, n = 47), did not experience palpitations (Non, n = 46), and healthy women (Control, n = 36)...
October 16, 2023: Immunologic Research
https://read.qxmd.com/read/37818199/hyaluronic-acid-fillers-and-asia-syndrome-case-studies
#3
Agnieszka Owczarczyk-Saczonek, Koenraad De Boulle
A continuous increase in the popularity of esthetic procedures with the use of substances as HA has been observed for many years, which might be contributing to an increase in the number of adverse events. The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) can be provoked by hyaluronic acid (HA), which belongs to substances meeting the criteria of adjuvants. Mechanisms of the innate and acquired immune response are activated, leading to the dysregulation of T and B lymphocytes, inability to recognize one's own antigens, inflammation, damage to one's own tissues, and ultimately to autoimmunity...
2023: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/37775577/autoimmune-autoinflammatory-syndrome-induced-by-adjuvants-asia-after-injection-of-foreign-materials-for-cosmetic-purposes-retrospective-analysis-of-1027-cases
#4
JOURNAL ARTICLE
Beatriz Hatsue Kushida-Contreras, Brenda Gómez-Calva, Bruno Mendoza-Ramírez, Miguel Angel Gaxiola-García
BACKGROUND: The injection of illicit, non-regulated foreign materials may trigger an autoimmune autoinflammatory syndrome induced by adjuvants (ASIA). METHODS: A retrospective review of health records was performed to identify patients' epidemiological and clinical characteristics. The issues analyzed were age and gender of cases, occupation, the person who administered the substance, anatomical site, type and volume of the injected substance, time from injection to the onset of symptoms, chief complaint, measures taken to alleviate symptoms, local complications, systemic manifestations, and imaging method to aid in diagnosis...
September 29, 2023: Aesthetic Plastic Surgery
https://read.qxmd.com/read/37714420/breast-implant-illness-is-it-causally-related-to-breast-implants
#5
REVIEW
Jan Willem Cohen Tervaert, Yehuda Shoenfeld, Claudio Cruciani, Carlotta Scarpa, Franco Bassetto
Once believed to be completely inert implants, Silicon Breast Implants (SBIs) have been shown to be able to induce a chronic inflammatory response in the body which can lead to a variety of possible manifestations ranging from the most common capsular contraction to rarer conditions such as malignancies and autoimmune diseases. Among the latter, new syndromes have been consistently recognized: Breast Implant Illness (BII) and autoimmunity/autoinflammatory syndrome induced by adjuvants (ASIA syndrome/Shoenfeld's Syndrome)...
September 13, 2023: Autoimmunity Reviews
https://read.qxmd.com/read/37691704/one-step-glandular-reconstruction-after-breast-implant-removal-technical-refinements-and-grafting-of-the-inferior-dermoglandular-flap
#6
JOURNAL ARTICLE
Leonardo Ioppolo, Antonio Amenta, Mario Alessandri-Bonetti, Francesco Borelli, Marco Calapai, Paolo Veronesi, Francesca De Lorenzi
The number of breast implant removal procedures are rising. Among the reasons why patients seek breast implant removal, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also named breast implant illness, is increasingly common. ASIA is an entity that incorporates diverse autoimmune conditions induced by the exposure to various adjuvants, including silicone, and it is characterized by systemic symptoms reminiscent of autoimmune disorders. Implant removal has the most effective treatment for ASIA...
September 2023: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/37581699/silicone-prosthetics-and-anti-thyroid-autoimmunity
#7
JOURNAL ARTICLE
V G Zolotykh, A N Gvozdetckii, V A Maevskaya, V J Utekhin, L P Churilov, Y Shoenfeld, P K Yablonskiy
INTRODUCTION: In esthetic surgery, the use of silicone implants is a topic of hot discussion. MATERIAL AND METHODS: An analysis of 119 esthetic surgical interventions on the mammary gland was performed. A study of the immune and endocrine parameters after mammoplasty was carried out. RESULTS: The phenomenon of an increase in the levels of autoantibodies to the TSH receptor was revealed. The phenomenon of pre-operative growth of prolactin and TSH levels has been confirmed...
August 15, 2023: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/37509537/new-onset-autoimmune-diseases-after-the-sputnik-vaccine
#8
JOURNAL ARTICLE
Olga Vera-Lastra, Gabriela Mora, Abihai Lucas-Hernández, Alberto Ordinola-Navarro, Emmanuel Rodríguez-Chávez, Ana Lilia Peralta-Amaro, Gabriela Medina, María Pilar Cruz-Dominguez, Luis J Jara, Yehuda Shoenfeld
The vertiginous advance for identifying the genomic sequence of SARS-CoV-2 allowed the development of a vaccine including mRNA-based vaccines, inactivated viruses, protein subunits, and adenoviral vaccines such as Sputnik. This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. Patients and Methods: A retrospective study was conducted on patients with new-onset autoimmune diseases induced by a post-COVID-19 vaccine between March 2021 and December 2022, in two referral hospitals in Mexico City and Argentina...
July 4, 2023: Biomedicines
https://read.qxmd.com/read/37424740/autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-medical-treatment-of-severe-systemic-compromise-case-report
#9
Germán Eduardo Puerta Sarmiento, Inés Modragón, Alex Echeverri, Luz Fernanda Sua, Fabio Bonilla-Abadía, David Aguirre-Valencia
CASE DESCRIPTION: A 42-year-old woman with severe pulmonary and mediastinal inflammatory involvement, secondary to infiltration of a silicone-related allogenic material with systemic migration. CLINICAL FINDINGS: The patient developed esophageal and bronchial stenosis, recurrent infections, malnutrition, and respiratory deterioration, making surgical removal of the allogenic material impossible. TREATMENT AND OUTCOME: Clinical and radiological improvement was achieved after treatment with multiple intravenous and oral immunomodulators...
2023: Colombia Médica: CM
https://read.qxmd.com/read/37316819/graves-disease-after-exposure-to-the-sars-cov-2-vaccine-a-case-report-and-review-of-the-literature
#10
REVIEW
Kai Takedani, Masakazu Notsu, Naoto Ishiai, Yu Asami, Kazuhiko Uchida, Keizo Kanasaki
BACKGROUND: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is characterized by immune system dysregulation after exposure to adjuvants, such as aluminum. Although cases of autoimmune thyroid diseases caused by ASIA have been reported, Graves' disease is one of the rarer diseases. There are some reports that vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause ASIA. Here, we describe a case of Graves' disease following SARS-CoV-2 vaccination and a review of the literature...
June 15, 2023: BMC Endocrine Disorders
https://read.qxmd.com/read/37287963/autoimmune-inflammatory-syndrome-induced-by-adjuvants-in-a-woman-with-hashimoto-thyroiditis-and-familial-autoimmunity-a-case-report-and-literature-review
#11
REVIEW
Aleksandra Plavsic, Snezana Arandjelovic, Milan Dimitrijevic, Natasa Kusic, Vesna Tomic Spiric, Bojana Popovic, Zikica Jovicic, Aleksandra Peric Popadic, Rada Miskovic
INTRODUCTION: Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) consists of a wide spectrum of symptoms and immunological features that are believed to develop in predisposed individuals after exposure to an adjuvant, including a silicone breast implant (SBI). Different autoimmune diseases (AIDs) have been associated with ASIA, but ASIA development after SBI in women with Hashimoto thyroiditis (HT) and familial autoimmunity has rarely been described. CASE REPORT: A 37-year-old woman presented in 2019 with arthralgia, sicca symptoms, fatigue, + antinuclear antibody (ANA), + anti SSA, and + anticardiolipin Immunoglobulin G (IgG) antibodies...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37271772/silicone-breast-implants-may-contribute-to-early-onset-fetal-growth-restriction
#12
JOURNAL ARTICLE
Silvia Hoirisch-Clapauch
INTRODUCTION: There are many studies showing that silicone breast implants may affect lactation, but few analyzed whether these implants affect placentation. We observed that many mothers with growth-restricted pregnancies had inflammatory conditions, such as silicone breast implants or giardiasis. METHODS: This single-center cohort study assessed the prevalence of inflammatory conditions in normotensive growth-restricted singleton pregnancies. Next, we stratified the patients according to the presence or absence of silicone breast implants, to determine whether these implants influence fetal growth restriction onset or severity...
June 5, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37252417/new-onset-thyroid-eye-disease-after-covid-19-vaccination-in-a-radioactive-iodine-treated-graves-disease-patient-a-case-report-and-literature-review
#13
REVIEW
Jamie Hong Im Teoh, Norlaila Mustafa, Norasyikin Wahab
Autoimmunity associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been well-described as the mechanism of development of thyroid dysfunction following Coronavirus Disease 19 (COVID-19) infection and SARS-CoV-2 vaccination. However, the occurrence of thyroid eye disease (TED) after SARS-CoV-2 vaccination is scarcely described. The postulated mechanisms include immune reactivation, molecular mimicry and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). We report a case of new-onset TED after receiving the SARS-CoV-2 vaccine...
2023: Journal of the ASEAN Federation of Endocrine Societies
https://read.qxmd.com/read/37211922/real-world-tolerance-and-outcomes-of-oxaliplatin-based-adjuvant-chemotherapy-for-stage-iii-colon-cancer-does-dose-intensity-matter
#14
JOURNAL ARTICLE
Robert Yoon, Kate Wilkinson, Gabriel Gabriel, Nasreen Kadaan, Tara Roberts, Stephanie Lim, Ray Asghari, Cheok Soon Lee, Wei Chua, Weng Ng
INTRODUCTION: Fluoropyrimidine and oxaliplatin-based adjuvant chemotherapy delivered as 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX), or capecitabine and oxaliplatin (CAPOX) is the standard of care for resected stage III colon cancer. Without randomized trial data, we compared real-world dose intensity, survival outcomes, and tolerability of these regimens. METHODS: Records of patients treated with FOLFOX or CAPOX in the adjuvant setting for stage III colon cancer across four institutions in Sydney during 2006-2016 were reviewed...
May 22, 2023: Asia-Pacific Journal of Clinical Oncology
https://read.qxmd.com/read/37109576/sarcoidosis-and-autoimmune-inflammatory-syndrome-induced-by-adjuvants
#15
REVIEW
Anna Starshinova, Yulia Zinchenko, Anna Malkova, Dmitriy Kudlay, Igor Kudryavtsev, Piotr Yablonskiy
Currently, sarcoidosis remains one of the diseases with unknown etiology, which significantly complicates its diagnosis and treatment. Various causes of sarcoidosis have been studied for many years. Both organic and inorganic trigger factors, provoking the development of granulomatous inflammation are considered. However, the most promising and evidence-based hypothesis is the development of sarcoidosis as an autoimmune disease, provoked by various adjuvants in genetic predisposed individuals. This concept fits into the structure of the autoimmune/inflammatory syndrome, induced by adjuvants (ASIA) that was proposed in 2011 by Professor Shoenfeld Y...
April 19, 2023: Life
https://read.qxmd.com/read/37069724/a-review-of-thyroid-dysfunction-due-to-covid-19
#16
JOURNAL ARTICLE
Alireza Arefzadeh
UNLABELLED: Coronavirus disease 2019 (COVID-19) affects thyroid function. These changes are due to the direct impact of the virus on thyroid cells via angiotensin-converting–enzyme 2 (ACE2) receptors, inflammatory reaction, apoptosis in thyroid follicular cells, suppression of hypothalamus-pituitary-thyroid axis, an increase in activity of adrenocortical axis, and excess cortisol release due to cytokine storm of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Euthyroid sick syndrome (ESS), thyroiditis, clinical and subclinical hypothyroidism, central hypothyroidism, exacerbation of underlying autoimmune thyroid disease, and clinical and subclinical hyperthyroidism can be associated with coronavirus...
April 13, 2023: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/36920514/takayasu-arteritis-associated-with-autoimmune-inflammatory-syndrome-induced-by-adjuvants-a-case-based-review
#17
REVIEW
Desislava Simeonova, Tsvetoslav Georgiev, Tanya Shivacheva
Takayasu's arteritis (TA) is a chronic granulomatous vasculitis that predominantly affects the aorta and its major branches. Despite advancements in the understanding of the pathogenic pathways of vascular inflammation, the etiology and predisposing factors of TA remain to be fully understood. In susceptible individuals, exposure to adjuvants may trigger, unlock or unmask an autoimmune disorder, presenting as non-specific constitutional symptoms or a fully developed autoimmune syndrome such as vasculitis. Here, we hypothesize that TA could be triggered by siliconosis, a subtype of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA)...
March 15, 2023: Rheumatology International
https://read.qxmd.com/read/36906391/clippers-syndrome-after-vaccination-an-unusual-asia-presentation
#18
Juan Saénz-Silva, Alberto Ordinola Navarro
The chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) were described a decade ago. There are a limited number of reports and these diseases are still underdiagnosed. We presented a 35 years-old patient with clinical manifestations of cerebellum affection and enhancement in the MRI, with the influenza vaccine as the only triggering factor. Infectious diseases, malignancy, and additional systemic involvement were ruled out; therefore, on suspicion of CLIPPERS syndrome, the patient received corticosteroid therapy with an adequate response...
March 2023: Reumatología clinica
https://read.qxmd.com/read/36895947/-brucea-javanica-oil-alleviates-intestinal-mucosal-injury-induced-by-chemotherapeutic-agent-5-fluorouracil-in-mice
#19
JOURNAL ARTICLE
Xinghan Zheng, Liting Mai, Ying Xu, Minghui Wu, Li Chen, Baoyi Chen, Ziren Su, Jiannan Chen, Hongying Chen, Zhengquan Lai, Youliang Xie
Background: Brucea javanica (L.) Merr, has a long history to be an anti-dysentery medicine for thousand of years, which is commonly called "Ya-Dan-Zi" in Chinese. The common liquid preparation of its seed, B. javanica oil (BJO) exerts anti-inflammatory action in gastrointestinal diseases and is popularly used as an antitumor adjuvant in Asia. However, there is no report that BJO has the potential to treat 5-Fluorouracil (5-FU)-induced chemotherapeutic intestinal mucosal injury (CIM). Aim of the study: To test the hypothesis that BJO has potential intestinal protection on intestinal mucosal injury caused by 5-FU in mice and to explore the mechanisms...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36881788/autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-past-present-and-future-implications
#20
JOURNAL ARTICLE
Isa Seida, Mahmoud Alrais, Ravend Seida, Abdulkarim Alwani, Zeynep Kiyak, Abdulrahman Elsalti, Sevval Nil Esirgun, Tunahan Abali, Naim Mahroum
Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning as when added to vaccines they are meant to boost the effect and strongly stimulate the immune system. The response of the immune system can be unpredictable, and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed to address possible adverse reactions of an autoimmune and inflammatory type that may be caused by adjuvants. While ASIA, as a syndrome, was coined and defined in 2011; reports describing patients with vague and nonspecific clinical symptoms following vaccinations appeared much earlier...
March 7, 2023: Clinical and Experimental Immunology
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