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Graphene biocompatibility

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https://www.readbyqxmd.com/read/29053255/fabrication-of-non-toxic-reduced-graphene-oxide-protein-nano-framework-as-sustained-antimicrobial-coating-for-biomedical-application
#1
Priyadarshani Choudhary, Thanusu Parandhaman, Baskaran Ramalingam, Natarajan Duraipandy, Manikantan Syamala Kiran, Sujoy K Das
Bacterial colonization on medical devices is a major concern in the healthcare industry. In the present study we report synthesis of environmental sustainable reduced graphene oxide (rGO) at large scale through biosynthetic route and its potential application for antibacterial coating on medical devices. HRTEM image depicts formation of graphene nanosheet, while DLS and ζ potential studies reveal that in aqueous medium the average hydrodynamic size and surface charge of rGO are 4410 ± 116 nm and -25.2 ± 3...
October 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29040962/interactions-between-rgo-tnt-nanocomposites-and-cells-regulation-of-cell-morphology-uptake-cytotoxicity-adhesion-and-migration
#2
Xiaopeng Su, Lifeng Yang, Cailian Huang, Qinli Hu, Xinyi Shan, Junmin Wan, Zhiwen Hu, Bing Wang
Reduced graphene oxide/titanium dioxide nanotube (rGO/TNT) composites have superior properties, such as a large surface area, extraordinary mechanical strength, high carrier mobility, etc. However, the biosafety and biocompatibility of these composites, such as their influences on cell viability and cell functions, which are of paramount importance, are still not fully addressed. In this study, rGO/TNT nanocomposites were successfully synthesized through a modified hydrothermal treatment method. Then, the interactions between the rGO/TNT nanocomposites and Raw264...
October 9, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29034936/synergistic-antiviral-effect-of-curcumin-functionalized-graphene-oxide-against-respiratory-syncytial-virus-infection
#3
Xiao Xi Yang, Chun Mei Li, Yuan Fang Li, Jian Wang, Cheng Zhi Huang
The diseases attributable to viruses remain a global burden. The respiratory syncytial virus (RSV), which is considered as the major viral pathogen of the lower respiratory tract of infants, has been implicated in severe lung disease. In this contribution, we developed a β-cyclodextrin (CD) functionalized graphene oxide (GO) composite, which displayed excellent antiviral activity and could load curcumin efficiently. RSV, a negative-sense single-stranded enveloped RNA virus, was employed as a model virus to investigate the antiviral activity of multifunctional GO...
October 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29031886/zif-67-derived-porous-co3o4-hollow-nanopolyhedron-functionalized-solution-gated-graphene-transistors-for-simultaneous-detection-of-glucose-and-uric-acid-in-tears
#4
Can Xiong, Tengfei Zhang, Weiyu Kong, Zhixiang Zhang, Hao Qu, Wei Chen, Yanbo Wang, Linbao Luo, Lei Zheng
Biomarkers in tears have attracted much attention in daily healthcare sensing and monitoring. Here, highly sensitive sensors for simultaneous detection of glucose and uric acid are successfully constructed based on solution-gated graphene transistors (SGGTs) with two separate Au gate electrodes, modified with GOx-CHIT and BSA-CHIT respectively. The sensitivity of the SGGT is dramatically improved by co-modifying the Au gate with ZIF-67 derived porous Co3O4 hollow nanopolyhedrons. The sensing mechanism for glucose sensor is attributed to the reaction of H2O2 generated by the oxidation of glucose near the gate, while the sensing mechanism for uric acid is due to the direct electro-oxidation of uric acid molecules on the gate...
October 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29030671/graphene-based-label-free-electrochemical-aptasensor-for-rapid-and-sensitive-detection-of-foodborne-pathogen
#5
Shalini Muniandy, Ignatius Julian Dinshaw, Swe Jyan Teh, Chin Wei Lai, Fatimah Ibrahim, Kwai Lin Thong, Bey Fen Leo
Reduced graphene oxide (rGO) has emerged as a promising nanomaterial for reliable detection of pathogenic bacteria due to its exceptional properties such as ultrahigh electron transfer ability, large surface to volume ratio, biocompatibility, and its unique interactions with DNA bases of the aptamer. In this study, rGO-azophloxine (AP) nanocomposite aptasensor was developed for a sensitive, rapid, and robust detection of foodborne pathogens. Besides providing an excellent conductive and soluble rGO nanocomposite, the AP dye also acts as an electroactive indicator for redox reactions...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29025665/cell-attachment-evaluation-of-the-immobilized-bioactive-peptide-on-a-nanographene-oxide-composite
#6
Behzad Adibi-Motlagh, Abbas Sahebghadam Lotfi, Aram Rezaei, Ehsan Hashemi
The immobilization of bioactive peptides as key molecules in numerous biological and physiological functions holds promise for designing advanced biomaterials. Graphene and its derivatives, having unique physicochemical properties, have brought considerable attention in the life sciences. In this regard, the chemical manipulation of the graphene surface with bioactive peptides opens a new horizon to design bioactive materials for a variety of future nanobiotechnologies. In this study, the first straightforward strategy for the covalent immobilization of the cell-adhesion peptide onto the graphene surface based on the Ugi four-component assembly process (Ugi 4-CAP) will be presented...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29024919/graphene-oxide-gold-nanorods-for-chemo-photothermal-treatment-and-controlled-release-of-doxorubicin-in-mice-tumor
#7
M Shahnawaz Khan, Sunil Pandey, Mukesh L Bhaisare, Gangaraju Gedda, Abou Talib, Hui-Fen Wu
Graphene oxide (GO) is a close derivative of graphene has unlocked many pivotal steps in drug delivery due to their inherent biocompatibility, excellent drug loading capacity, and shows antibacterial, antifungal properties etc. We used a novel plant material called Gum arabic (GA) to increase the solubility of GO as well as to chemically reduce it in the solution. GA functionalized GO (fGO) exhibited increased absorption in near infra-red region (NIR) which was exploited in photothermal therapy for cancer. In order to understand the shape and size effect of GO which may affect their rheological properties, we have conjugated them with gold nanorods (GNRs) using in situ synthesis of GO@GNRs via seed mediated method...
September 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29023399/novel-anti-tuberculosis-nanodelivery-formulation-of-ethambutol-with-graphene-oxide
#8
Bullo Saifullah, Alina Chrzastek, Arundhati Maitra, Bullo Naeemullah, Sharida Fakurazi, Sanjib Bhakta, Mohd Zobir Hussein
Tuberculosis (TB) is a bacterial disease responsible for millions of infections and preventable deaths each year. Its treatment is complicated by patients' noncompliance due to dosing frequency, lengthy treatment, and adverse side effects associated with current chemotherapy. However, no modifications to the half-a-century old standard chemotherapy have been made based on a nanoformulation strategy to improve pharmacokinetic efficacy. In this study, we have designed a new nanodelivery formulation, using graphene oxide as the nanocarrier, loaded with the anti-TB antibiotic, ethambutol...
October 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29022942/facile-synthesis-of-gold-nanomaterials-with-unusual-crystal-structures
#9
Zhanxi Fan, Xiao Huang, Ye Chen, Wei Huang, Hua Zhang
Gold (Au) nanomaterials have attracted wide research attention, owing to their high chemical stability, promising catalytic properties, excellent biocompatibility, unique electronic structure and outstanding localized surface plasmon resonance (LSPR) absorption properties; all of which are closely related to their size and shape. Recently, crystal-phase-controlled synthesis of noble metal nanomaterials has emerged as a promising strategy to tune their physicochemical properties. This protocol describes the detailed experimental procedures for the crystal-phase-controlled syntheses of Au nanomaterials with unusual crystal structures under mild conditions...
November 2017: Nature Protocols
https://www.readbyqxmd.com/read/28994582/internal-light-source-driven-photoelectrochemical-3d-rgo-cellulose-device-based-on-cascade-dna-amplification-strategy-integrating-target-analog-chain-and-dna-mimic-enzyme
#10
Feifei Lan, Linlin Liang, Yan Zhang, Li Li, Na Ren, Mei Yan, Shenguang Ge, Jinghua Yu
In this work, a chemiluminescence-driven collapsible greeting card-like photoelectrochemical lab-on-paper device (GPECD) with hollow channel was demonstrated, in which target-triggering cascade DNA amplification strategy was ingeniously introduced. The GPECD had the functions of reagents storage and signal collection, and the change of configuration could control fluidic path, reaction time and alterations in electrical connectivity. In addition, three-dimentional reduced graphene oxide affixed Au flower was in situ grown on paper cellulose fiber for achieving excellent conductivity and biocompatibility...
October 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28982091/facile-synthesis-of-mos2-cu2o-pt-nanohybrid-as-enzyme-mimetic-label-for-the-detection-of-the-hepatitis-b-surface-antigen
#11
Faying Li, Yueyun Li, Jinhui Feng, Zengqiang Gao, Hui Lv, Xiang Ren, Qin Wei
An ultrasensitive sandwich-type electrochemical immunosensor was proposed for quantitative detection of hepatitis B surface antigen, which is a representative biomarker of the Hepatitis B virus. First, the porous graphene oxide/Au composites with good conductive ability were employed to accelerate the electron transfer on the electrode interface. Furthermore, the amino functionalized molybdenum disulfide @ cuprous oxide hybrid with coral morphology was prepared to combine platinum nanoparticles for achieving signal amplification strategy...
September 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28974044/magnetic-force-driven-graphene-patterns-to-direct-synaptogenesis-of-human-neuronal-cells
#12
Kyung-Joon Min, Tae-Hyung Kim, Jeong-Woo Choi
Precise control of axonal growth and synaptic junction formation are incredibly important to repair and/or to mimic human neuronal network. Here, we report a graphene oxide (GO)-based hybrid patterns that were proven to be excellent for guiding axonal growth and its consequent synapse formation of human neural cells. Unlike the previous method that utilized micro-contacting printing technique to generate GO patterns, here, GO-encapsulated magnetic nanoparticles were first synthesized and utilized as core materials wherein the external magnetic force facilitated the transfer of GO film to the desired substrate...
October 2, 2017: Materials
https://www.readbyqxmd.com/read/28967299/a-new-electrospun-graphene-silk-fibroin-composite-scaffolds-for-guiding-schwann-cells
#13
Yahong Zhao, Jiahuan Gong, Changmei Niu, Ziwei Wei, Jiaqi Shi, Guohui Li, Yumin Yang, Hongbo Wang
Graphene (Gr) has been made of various forms used for repairing peripheral nerve injury with favorable electroactivity, however, graphene-based scaffolds in peripheral nerve regeneration are still rarely reported due to the difficulty of realizing uniform dispersion of graphene and electroactive materials at nanoscale as well as lacking biocompatibility. In this paper, graphene-silk fibroin (SF) composite nanofiber membranes with different mass ratios were prepared via electrospinning. Microscopic observation revealed that electrospun Gr/SF membranes had a nanofibrous structure...
September 30, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28961225/graphene-quantum-dots-electrochemistry-and-sensitive-electrocatalytic-glucose-sensor-development
#14
Sanju Gupta, Tyler Smith, Alexander Banaszak, John Boeckl
Graphene quantum dots (GQDs), derived from functionalized graphene precursors are graphene sheets a few nanometers in the lateral dimension having a several-layer thickness. They are zero-dimensional materials with quantum confinement and edge site effects. Intense research interest in GQDs is attributed to their unique physicochemical phenomena arising from the sp²-bonded carbon nanocore surrounded with edged plane functional moieties. In this work, GQDs are synthesized by both solvothermal and hydrothermal techniques, with the optimal size of 5 nm determined using high-resolution transmission electron microscopy, with additional UV-Vis absorption and fluorescence spectroscopy, revealing electronic band signatures in the blue-violet region...
September 29, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28953408/injectable-shear-thinning-fluorescent-hydrogel-formed-by-cellulose-nanocrystals-and-graphene-quantum-dots
#15
Amir Khabibullin, Moien Alizadehgiashi, Nancy Khuu, Elisabeth Prince, Moritz Tebbe, Eugenia Kumacheva
In the search for new building blocks of nanofibrillar hydrogels, cellulose nanocrystals (CNCs) have attracted great interest because of their sustainability, biocompatibility, ease of surface functionalization, and mechanical strength. Making these hydrogels fluorescent extends the range of their applications in tissue engineering, bioimaging, and biosensing. We report the preparation and properties of a multifunctional hydrogel formed by CNCs and graphene quantum dots (GQDs). We show that although CNCs and GQDs are both negatively charged, hydrogen bonding and hydrophobic interactions overcome the electrostatic repulsion between these nanoparticles and yield a physically cross-linked hydrogel with tunable mechanical properties...
October 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28951302/carboxymethyl-cellulose-modified-graphene-oxide-as-ph-sensitive-drug-delivery-system
#16
Ziqie Rao, Hongyu Ge, Liangling Liu, Chen Zhu, Lian Min, Meng Liu, Lihong Fan, Dan Li
Nanotechnology has been studied to improve drug delivery and cancer treatment. The aim of this study is to introduce amino groups into graphene oxide (GO) to form aminated fumed graphene (GO-ADH) and combine GO-ADH with carboxymethyl cellulose (CMC) to produce GO-CMC complex as a drug carrier matrix. The anti-cancer drug small molecule doxorubicin hydrochloride (DOX) was bond to GO-CMC by π-π bond interaction and hydrogen bonding to form GO-CMC/DOX drug loading system. Via the FT-IR, transmission electron microscopy (TEM) and Zeta potential analyzer analysis showed that GO-CMC complex was successfully synthesized...
September 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28929741/visible-light-neural-stimulation-on-graphitic-carbon-nitride-graphene-photocatalytic-fibers
#17
Zhongyang Zhang, Ruodan Xu, Zegao Wang, Mingdong Dong, Bianxiao Cui, Menglin Chen
Light stimulation allows remote and spatiotemporally accurate operation that has been applied as effective, noninvasive means of therapeutic interventions. Here, visible-light neural stimulation of graphitic carbon nitride (g-C3N4), an emerging photocatalyst with visible-light optoelectronic conversion, was for the first time investigated. Specifically, g-C3N4 was combined with graphene oxide (GO) in a three-dimensional manner on the surfaces of electrospun polycaprolactone/gelatin (PG) fibers and functioned as a biocompatible interface for visible-light stimulating neuronal differentiation...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28928402/core-shell-heterostructured-multiwalled-carbon-nanotubes-reduced-graphene-oxide-nanoribbons-chitosan-a-robust-nanobiocomposite-for-enzymatic-biosensing-of-hydrogen-peroxide-and-nitrite
#18
Veerappan Mani, Mani Govindasamy, Shen-Ming Chen, Tse-Wei Chen, Annamalai Senthil Kumar, Sheng-Tung Huang
A robust nanobiocomposite based on core-shell heterostructured multiwalled carbon nanotubes@reduced graphene oxide nanoribbons (MWCNTs@rGONRs)/chitosan (CHIT) was described for the fabrication of sensitive, selective, reproducible and durable biosensor for hydrogen peroxide (H2O2) and nitrite (NO2(-)). The excellent physicochemical properties of MWCNTs@rGONRs such as, presence of abundant oxygen functionalities, higher area-normalized edge-plane structures and chemically active sites in combination with excellent biocompatibility of CHIT resulting in the versatile immobilization matrix for myoglobin (Mb)...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925946/development-and-biocompatibility-evaluation-of-photocatalytic-tio%C3%A2-reduced-graphene-oxide-based-nanoparticles-designed-for-self-cleaning-purposes
#19
Ionela Cristina Nica, Miruna S Stan, Marcela Popa, Mariana Carmen Chifiriuc, Gratiela G Pircalabioru, Veronica Lazar, Iuliana Dumitrescu, Lucian Diamandescu, Marcel Feder, Mihaela Baibarac, Marin Cernea, Valentin Adrian Maraloiu, Traian Popescu, Anca Dinischiotu
Graphene is widely used in nanotechnologies to amplify the photocatalytic activity of TiO₂, but the development of TiO₂/graphene composites imposes the assessment of their risk to human and environmental health. Therefore, reduced graphene oxide was decorated with two types of TiO₂ particles co-doped with 1% iron and nitrogen, one of them being obtained by a simultaneous precipitation of Ti(3+) and Fe(3+) ions to achieve their uniform distribution, and the other one after a sequential precipitation of these two cations for a higher concentration of iron on the surface...
September 19, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28925683/3d-nanostructured-palladium-functionalized-graphene-aerogel-supported-fe3o4-for-enhanced-ru-bpy-3-2-based-electrochemiluminescent-immunosensing-of-prostate-specific-antigen
#20
Lei Yang, Yueyuan Li, Yong Zhang, Dawei Fan, Xuehui Pang, Qin Wei, Bin Du
We developed a novel Ru(bpy)3(2+)-based electrochemiluminescence (ECL) immunosensor utilizing palladium nanoparticle (Pd NP)-functionalized graphene-aerogel-supported Fe3O4 (FGA-Pd) for real-sample analysis of prostate specific antigen (PSA). 3D nanostructured FGA-Pd, as a novel ECL carrier, was prepared by in situ reduction. Large amounts of Ru(bpy)3(2+) could combine with FGA-Pd via electrostatic interaction to establish a brand-new ECL emitter (Ru@FGA-Pd) for improving ECL efficiency. The obtained Ru@FGA-Pd composite was utilized to label the secondary antibody, which generated strong ECL signals with tripropylamine (TPrA) as a coreactant...
October 11, 2017: ACS Applied Materials & Interfaces
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