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Graphene biocompatibility

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https://www.readbyqxmd.com/read/28208260/simultaneous-enhancement-of-bioactivity-and-stability-of-laccase-by-cu-2-paa-ppega-matrix-for-efficient-biosensing-and-recyclable-decontamination-of-pyrocatechol
#1
Tao Chen, Yuanhong Xu, Zhi Peng, Aihua Li, Jingquan Liu
Simultaneously enhancing the catalytic bioactivity and stability of enzyme is still an intractable issue in the enzymatic study. Herein, a facile and effective approach was designed to immobilize and modify laccase on a Cu(2+)-adsorbed pyrene-terminated block copolymer [poly(acrylic acid)/poly(poly(ethylene glycol) acrylate)] (PAA/PPEGA), which was prepared via well-controlled reversible addition-fragmentation chain transfer polymerization. PAA provided the supporting matrix for firm immobilization of Cu(2+), an enzyme bioactivity inducer, onto the microstructure of laccase, while avoiding any contamination of the heavy metal Cu(2+) into the following application system...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28208019/cyanographene-and-graphene-acid-emerging-derivatives-enabling-high-yield-and-selective-functionalization-of-graphene
#2
Aristides Bakandritsos, Martin Pykal, Piotr Blonski, Petr Jakubec, Demetrios D Chronopoulos, Katerina Polakova, Vasilios Georgakilas, Klára Čépe, Ondrej Tomanec, Vaclav Ranc, Athanasios B Bourlinos, Radek Zboril, Michal Otyepka
Efficient and selective methods for covalent derivatization of graphene are needed because they enable tuning of graphene's surface and electronic properties, thus expanding its application potential. However, existing approaches based mainly on chemistry of graphene and graphene oxide achieve only limited level of functionalization due to chemical inertness of the surface and non-selective simultaneous attachment of different functional groups, respectively. Here we present a conceptually different route based on synthesis of cyanographene via the controllable substitution and defluorination of fluorographene...
February 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28199121/smart-contact-lenses-with-graphene-coating-for-electromagnetic-interference-shielding-and-dehydration-protection
#3
Sangkyu Lee, Insu Jo, Sangmin Kang, Bongchul Jang, Joonhee Moon, Jong Bo Park, Soochang Lee, Sichul Rho, Youngsoo Kim, Byung Hee Hong
Recently, smart contact lenses with electronic circuits have been proposed for various sensor and display applications, where the use of flexible and biologically stable electrode materials is essential. Graphene is an atomically thin carbon materials with 2-dimensional hexagonal lattice, showing outstanding electrical and mechanical properties as well as excellent biocompatibility. In addition, graphene is capable of protecting eyes from electromagnectic (EM) waves that may cause eye diseases such as cataracts...
February 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28191446/guiding-osteogenesis-of-mesenchymal-stem-cells-using-carbon-based-nanomaterials
#4
REVIEW
Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Sung-Sik Choo, Seung-Jae Kim, Inbeom Song, Tae-Hyung Kim
In the field of regenerative medicine, stem cells are highly promising due to their innate ability to generate multiple types of cells that could replace/repair damaged parts of human organs and tissues. It has been reported that both in vitro and in vivo function/survival of stem cells could significantly be improved by utilizing functional materials such as biodegradable polymers, metal composites, nanopatterns and nanohybrid particles. Of various biocompatible materials available for use in stem cell-based therapy and research, carbon-based materials-including fullerenes graphene/graphene oxide and carbon nanotubes-have been found to possess unique physicochemical characteristics that contribute to the effective guidance of stem cell differentiation into specific lineages...
2017: Nano Converg
https://www.readbyqxmd.com/read/28186213/multifunctional-biocompatible-and-ph-responsive-carbon-nanotube-and-graphene-oxide-tectomer-hybrid-composites-and-coatings
#5
Rosa Garriga, Izabela Jurewicz, Shayan Seyedin, Niki Bardi, Stella Totti, Brigitta Matta-Domjan, Eirini G Velliou, Mohammed A Alkhorayef, Vicente L Cebolla, Joselito M Razal, Alan B Dalton, Edgar Muñoz
Here we present a route for non-covalent functionalization of carboxylated multi-walled carbon nanotubes and graphene oxide with novel two-dimensional peptide assemblies. We show that self-assembled amino-terminated biantennary and tetraantennary oligoglycine peptides (referred to as tectomers) effectively coat carboxylated multi-walled carbon nanotubes and also strongly interact with graphene oxide due to electrostatic interactions and hydrogen bonding as the driving force, respectively. The resulting hybrids can be made into free-standing conducting composites or applied in the form of thin, pH-switchable bioadhesive coatings onto graphene oxide fibers...
February 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28186128/ultrasensitive-label-free-electrochemical-immunosensor-based-on-multifunctionalized-graphene-nanocomposites-for-the-detection-of-alpha-fetoprotein
#6
Yaoguang Wang, Yong Zhang, Dan Wu, Hongmin Ma, Xuehui Pang, Dawei Fan, Qin Wei, Bin Du
In this work, a novel label-free electrochemical immunosensor was developed for the quantitative detection of alpha fetoprotein (AFP). Multifunctionalized graphene nanocomposites (TB-Au-Fe3O4-rGO) were applied to modify the electrode to achieve the amplification of electrochemical signal. TB-Au-Fe3O4-rGO includes the advantages of graphene, ferroferric oxide nanoparticles (Fe3O4 NPs), gold nanoparticles (Au NPs) and toluidine blue (TB). As a kind of redox probe, TB can produce the electrochemical signal. Graphene owns large specific surface area, high electrical conductivity and good adsorption property to load a large number of TB...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28183673/attenuation-of-the-in-vitro-neurotoxicity-of-316l-ss-by-graphene-oxide-surface-coating
#7
Nishat Tasnim, Alok Kumar, Binata Joddar
A persistent theme in biomaterials research comprises of surface engineering and modification of bare metallic substrates for improved cellular response and biocompatibility. Graphene Oxide (GO), a derivative of graphene, has outstanding chemical and mechanical properties; its large surface to volume ratio, ease of surface modification and processing make GO an attractive coating material. GO-coatings have been extensively studied as biosensors. Further owing to its surface nano-architecture, GO-coated surfaces promote cell adhesion and growth, making it suitable for tissue engineering applications...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28167110/synthesis-of-a-novel-biocompatible-nanocomposite-of-graphene-oxide-and-magnetic-nanoparticles-for-drug-delivery
#8
Majid Aliabadi, Hamidreza Shagholani, Arash Yunessnia Lehi
The combination of imaging and delivery systems through nanoscale material have been used to create new nanoparticle formulations for biological applications. Here, a magnetic nanocomposite consisting of superparamagnetic iron oxide nanoparticles (SPIONs), graphene oxide (GO), chitosan and poly(vinyl alcohol) (PVA) as biocompatible polymers was synthesized for applying in drug delivery and imaging agent. The nanocomposite was studied by various techniques including XRD, TEM, FE-SEM, FT-IR and VSM. SPIONs had an average diameter size about 10nm and showed superparamagnetic behavior...
February 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28164151/graphene-foam-as-a-three-dimensional-platform-for-myotube-growth
#9
Eric Krueger, A Nicole Chang, Dale Brown, Josh Eixenberger, Raquel Brown, Sepideh Rastegar, Katie M Yocham, Kurtis D Cantley, David Estrada
This study demonstrates the growth and differentiation of C2C12 myoblasts into functional myotubes on 3-dimensional graphene foam bioscaffolds. Specifically, we establish both bare and laminin coated graphene foam as a biocompatible platform for muscle cells and identify that electrical coupling stimulates cell activity. Cell differentiation and functionality is determined by the expression of myotube heavy chain protein and Ca(2+) fluorescence, respectively. Further, our data show that the application of a pulsed electrical stimulus to the graphene foam initiates myotube contraction and subsequent localized substrate movement of over 100 micrometers...
August 8, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28161627/temperature-and-ph-sensors-based-on-graphenic-materials
#10
P Salvo, N Calisi, B Melai, B Cortigiani, M Mannini, A Caneschi, G Lorenzetti, C Paoletti, T Lomonaco, A Paolicchi, I Scataglini, V Dini, M Romanelli, R Fuoco, F Di Francesco
Point-of-care applications and patients' real-time monitoring outside a clinical setting would require disposable and durable sensors to provide better therapies and quality of life for patients. This paper describes the fabrication and performances of a temperature and a pH sensor on a biocompatible and wearable board for healthcare applications. The temperature sensor was based on a reduced graphene oxide (rGO) layer that changed its electrical resistivity with the temperature. When tested in a human serum sample between 25 and 43°C, the sensor had a sensitivity of 110±10Ω/°C and an error of 0...
January 27, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28161572/single-wavelength-light-mediated-synergistic-bimodal-cancer-photoablation-and-amplified-photothermal-performance-by-graphene-gold-nanostar-photosensitizer-theranostics
#11
Chunhui Wu, Dan Li, Lianhui Wang, Xiaotian Guan, Yuan Tian, Hong Yang, Shun Li, Yiyao Liu
: Light-triggered nanotheranostics opens a fascinating but challenging avenue to achieve simultaneous and highly efficient anticancer outcomes for multimodal therapeutic and diagnostic modalities. Herein, a multifunctional phototheranostics based on a photosensitizer-assembled graphene/gold nanostar hybrid (GO/AuNS-PEG) was developed for cancer synergistic photodynamic (PDT) and photothermal therapy (PTT) as well as effective photothermal imaging. The stable and biocompatible GO/AuNS-PEG composite displayed a high photothermal conversion efficiency due to the enhanced optical absorbance of both graphene and gold nanostars in the near-infrared (NIR) range...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28161500/gold-nanocages-decorated-biocompatible-amine-functionalized-graphene-as-an-efficient-dopamine-sensor-platform
#12
Sahar Daemi, Ali Akbar Ashkarran, Ali Bahari, Shahram Ghasemi
Nanocomposite of gold nanocages and chemically modified graphene oxide (GNCs/CMG) was synthesized in N,N-dimethylformamide (DMF) for sensitive detection of dopamine (DA). DA is widely spread in central nervous system which can regulates essential body functions like movement and emotional behaviour. In this regard sensitive and fast detection of DA level in human body is still challenging considering its interference with other biomolecules in biological samples. CMG was synthesized through amine modification of graphene oxide (GO) with DMF at relatively high temperature followed by attachment of GNCs, fabricated using a galvanic replacement between silver nanocubes and HAuCl4 solution in the DMF...
January 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28157658/macroporous-graphene-capped-fe3o4-for-amplified-electrochemiluminescence-immunosensing-of-carcinoembryonic-antigen-detection-based-on-ceo2-tio2
#13
Lei Yang, Wenjuan Zhu, Xiang Ren, Malik Saddam Khan, Yong Zhang, Bin Du, Qin Wei
A novel electrochemiluminescence (ECL) signal-amplified immunosensing strategy was proposed by using gold nanoparticles (Au NPs) functionalized reduced graphene oxide (rGO) capped Fe3O4 (Au-FrGO). In this work, CeO2@TiO2 was prepared by a sol-gel method to wrap CeO2 with TiO2. In the presence of CeO2, CeO2@TiO2 exhibited better ECL activity than TiO2 with peroxydisulfate as coreactant. In addition, FrGO with macroporous structure was synthesized by self-assembly of rGO sheets capped cationic Fe3O4 nanoparticles, exhibiting larger specific surface area than rGO...
January 26, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28139876/mild-binding-of-protein-to-c2-n-monolayer-reveals-its-suitable-biocompatibility
#14
Baoyu Li, Weifeng Li, Jose Manuel Perez-Aguilar, Ruhong Zhou
The development of biocompatible nanomaterials for smart drug delivery and bioimaging has attracted great interest in recent years in biomedical fields. Here, the interaction between the recently reported nitrogenated graphene (C2 N) and a prototypical protein (villin headpiece HP35) utilizing atomistic molecular dynamics simulations is studied. The simulations reveal that HP35 can form a stable binding with the C2 N monolayer. Although the C2 N-HP35 attractive interactions are constantly preserved, the binding strength between C2 N and the protein is mild and does not cause significant distortion in the protein's structural integrity...
January 31, 2017: Small
https://www.readbyqxmd.com/read/28135260/water-based-and-biocompatible-2d-crystal-inks-for-all-inkjet-printed-heterostructures
#15
Daryl McManus, Sandra Vranic, Freddie Withers, Veronica Sanchez-Romaguera, Massimo Macucci, Huafeng Yang, Roberto Sorrentino, Khaled Parvez, Seok-Kyun Son, Giuseppe Iannaccone, Kostas Kostarelos, Gianluca Fiori, Cinzia Casiraghi
Exploiting the properties of two-dimensional crystals requires a mass production method able to produce heterostructures of arbitrary complexity on any substrate. Solution processing of graphene allows simple and low-cost techniques such as inkjet printing to be used for device fabrication. However, the available printable formulations are still far from ideal as they are either based on toxic solvents, have low concentration, or require time-consuming and expensive processing. In addition, none is suitable for thin-film heterostructure fabrication due to the re-mixing of different two-dimensional crystals leading to uncontrolled interfaces and poor device performance...
January 30, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28112762/3d-printable-conducting-hydrogels-containing-chemically-converted-graphene
#16
Sepidar Sayyar, Sanjeev Gambhir, Johnson Chung, David L Officer, Gordon G Wallace
The development of conducting 3D structured biocompatible scaffolds for the growth of electroresponsive cells is critical in the field of tissue engineering. This work reports the synthesis and 3D processing of UV-crosslinkable conducting cytocompatible hydrogels that are prepared from methacrylated chitosan (ChiMA) containing graphenic nanosheets. The addition of chemically converted graphene resulted in mechanical and electrical properties of the composite that were significantly better than ChiMA itself, as well as improved adhesion, proliferation and spreading of L929 fibroblasts cells...
January 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28107626/polymeric-nanofibers-with-ultrahigh-piezoelectricity-via-self-orientation-of-nanocrystals
#17
Xia Liu, Jing Ma, Xiaoming Wu, Liwei Lin, Xiaohong Wang
Piezoelectricity in macromolecule polymers has been gaining immense attention, particularly for applications in biocompatible, implantable, and flexible electronic devices. This paper introduces core-shell-structured piezoelectric polyvinylidene fluoride (PVDF) nanofibers chemically wrapped by graphene oxide (GO) lamellae (PVDF/GO nanofibers), in which the polar β-phase nanocrystals are formed and uniaxially self-oriented by the synergistic effect of mechanical stretching, high-voltage alignment, and chemical interactions...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28099026/unimer-assisted-exfoliation-for-highly-concentrated-aqueous-dispersion-solutions-of-single-and-few-layered-van-der-waals-materials
#18
Changbong Yeon, Inyeal Lee, Gil-Ho Kim, Sun Jin Yun
We suggest a unimer-assisted exfoliation method for the exfoliation of van der Waals two-dimensional (2D) materials such as graphene, MoS2, and h-BN and show that the micellar size is a critical parameter for enhancing the exfoliation efficiency. To explain the effectiveness of the unimers in the exfoliation, the influence of the micellar size of a biocompatible block copolymer, Pluronic F-68, is evaluated in view of the yield and thickness of exfoliated 2D flakes. By the addition of water-soluble alcohols, the surfactants exist in the form of a unimer, which facilitates the intercalation into the layered materials and their exfoliation...
January 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28092742/short-term-in-vivo-exposure-to-graphene-oxide-can-cause-damage-to-the-gut-and-testis
#19
Marta Dziewięcka, Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
Graphene oxide (GO) has unique physicochemical properties and also has a potentially widespread use in every field of daily life (industry, science, medicine). Demand for nanotechnology is growing every year, and therefore many aspects of its toxicity and biocompatibility still require further clarification. This research assesses the in vivo toxicity of pure and manganese ion-contaminated GO that were administrated to Acheta domesticus with food (at 200mgkg(-1) of food) throughout their ten-day adult life...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28090771/differential-adhesive-and-bioactive-properties-of-the-polymeric-surface-coated-with-graphene-oxide-thin-film
#20
Sudhin Thampi, A Maya Nandkumar, Vignesh Muthuvijayan, Ramesh Parameswaran
Surface engineering of implantable devices involving polymeric biomaterials has become an essential aspect for medical implants. A surface enhancement technique can provide an array of unique surface properties that improve its biocompatibility and functionality as an implant. Polyurethane-based implants that have found extensively acclaimed usage as an implant in biomedical applications, especially in the area of cardiovascular devices, still lack any mechanism to ward off bacterial or platelet adhesion. To bring out such a defense mechanism we are proposing a surface modification technique...
January 30, 2017: ACS Applied Materials & Interfaces
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