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Graphene biocompatibility

Liu Wang, Zhicheng Huang, Yibo Liu, Jian Wu, Juewen Liu
Manganese dioxide (MnO2) is an interesting material due to its excellent biocompatibility and magnetic properties. Adsorption of DNA to MnO2 is potentially interest for drug delivery and sensing applications. However, little fundamental understanding is known about their interactions. In this work, carboxyfluorescein (FAM)-labeled DNA oligonucleotides were used to explore the effect of salt concentration, pH, and DNA sequence and length for adsorption by MnO2, and comparisons were made with graphene oxide (GO)...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Abbas Jafarizad, Ali Taghizadehgh-Alehjougi, Morteza Eskandani, Maryam Hatamzadeh, Mojtaba Abbasian, Rahim Mohammad-Rezaei, Maryam Mohammadzadeh, Başak Toğar, Mehdi Jaymand
This paper describes the development of mitoxantrone-loaded PEGylated graphene oxide/magnetite nanoparticles (PEG-GO/Fe3O4-MTX), and investigation of its preliminary drug delivery performance. For this, the GO was synthesized through oxidizing graphite powder, and subsequently carboxylated using a substitution nucleophilic reaction. The carboxylated GO (GO-COOH) was then conjugated with amine end-caped PEG chains by Steglich esterification. Afterward, GO-PEG/Fe3O4 nanocomposite was synthesized through the anchoring of Fe3O4 nanoparticles onto the surface of GO-PEG during the sonication...
2018: Bio-medical Materials and Engineering
Jun Jin, Mengyu Guo, Jiaming Liu, Jing Liu, Huige Zhou, Jiayang Li, Liming Wang, Huibiao Liu, Yuliang Li, Yuliang Zhao, Chunying Chen
Nowadays, two-dimensional (2D) materials have attracted extensive attention as cancer drug delivery platforms, owing to their unparalleled physicochemical properties and superior specific surface area. Graphdiyne (GDY) is a novel 2D carbon material. Compared to graphene, GDY not only has benzene rings composed of sp2 hybridized carbon atoms, but also has acetylene units composed of sp hybridized carbon atoms, therefore it possesses multiple conjugated electronic structures. Herein, we used doxorubicin (DOX) as a model drug to develop a GDY nanosheet-based drug delivery platform for a photothermal/chemo-therapy combination in living mice...
February 19, 2018: ACS Applied Materials & Interfaces
Qian Yu, Yongmei Wu, Zi Liu, Sheng Lei, Gaiping Li, Baoxian Ye
This work designed an artificial substrate peptide to synthesize peptide-hemin/G-quadruplex (peptide-DNAzyme) conjugates. In addition to enhancing catalytic activity of hemin/G-quadruplex, the peptide could also be induced and cleaved by prostate specific antigen (PSA). It was the first report on peptide-DNAzyme conjugates in application of the peptide biosensor. The polyethyleneimine-reduced graphene oxide@hollow platinum nanotubes (PEI-rGO@PtNTs) nanocomposites were cast on the glassy carbon electrode in order to form the interface of biocompatibility and huge surface area for bioprobes immobilization...
February 9, 2018: Biosensors & Bioelectronics
Qi Xu, Hao Yuan, Xulin Dong, Yan Zhang, Muhammad Asif, Zehua Dong, Wenshan He, Jinghua Ren, Yimin Sun, Fei Xiao
The development of high-efficient technologies for cancer biomarkers detection has attracted tremendous research effort for its great clinic significance. In this work, we designed a new type of flexible and robust nanohybrid microelectrode by modifying carbon fiber with dual nanoenzyme, i.e., AuPd alloy nanoparticles (AuPd-ANPs) decorated graphene quantum dots (GQDs) assembly, and explored its practical application in electrochemical sensing system for sensitive detection of cancer biomarker hydrogen peroxide (H2 O2 ) in human breast cancer cells and tissue...
February 9, 2018: Biosensors & Bioelectronics
Lingxia Wu, Xianbo Lu, Dhanjai, Zhong-Shuai Wu, Yanfeng Dong, Xiaohui Wang, Shuanghao Zheng, Jiping Chen
MXene-Ti 3 C 2 , as a new class of two-dimensional (2D) transition metal carbides (or nitrides), has been synthesized by exfoliating pristine Ti 3 AlC 2 phases with hydrofluoric acid. The SEM and XRD images show that the resultant MXene possesses a graphene-like 2D nanostructure. and the surface of MXene has been partially terminated with -OH, thus providing a favorable microenvironment for enzyme immobilization and retaining their bioactivity and stability. Considering the unique metallic conductivity, biocompatibility and good dispersion in aqueous phase, the as-prepared MXene was explored as a new matrix to immobilize tyrosinase (a model enzyme) for fabricating a mediator-free biosensor for ultrasensitive and rapid detection of phenol...
February 8, 2018: Biosensors & Bioelectronics
N R Dhineshbabu, E Walantina Bercy
In this article, the hydrophobic nature of colloidal silica sol prepared using the sol-gel method was studied. Uncoated cotton fabrics were impregnated with the prepared nanosols followed by pad-dry-cure method. The internal structure of nanosol was obtained through transmission electron microscopy. Graphene oxide nanostructures were deposited on the silica-coated fabrics by direct current (DC) magnetron sputtering techniques. The structural and morphological analyses of the coated and uncoated fabrics were performed using the X-ray diffraction and scanning electron microscopy techniques, respectively...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Sayan Ganguly, Debes Ray, Poushali Das, Priti Prasanna Maity, Subhadip Mondal, V K Aswal, Santanu Dhara, Narayan Ch Das
Nanohybrid hydrogels based on pristine graphene with enhanced toughness and dual responsive drug delivery feature is opening a new era for smart materials. Here pristine graphene hydrogels are synthesized by in situ free radical polymerization where graphene platelets are the nanobuiliding blocks to withstand external stress and shows reversible ductility. Such uniqueness is a mere reflection of rubber-like elasticity on the hydrogels. These nanobuilding blocks serve also the extensive physisorption which enhances the physical crosslinking inside the gel matrix...
April 2018: Ultrasonics Sonochemistry
Yaimara Solìs Moré, Gloria Panella, Giulia Fioravanti, Francesco Perrozzi, Maurizio Passacantando, Francesco Giansanti, Matteo Ardini, Luca Ottaviano, Annamaria Cimini, Carlos Peniche, Rodolfo Ippoliti
Novel 2D films and 3D scaffolds based on chitosan (CHI), apatite (Ap) and graphene oxide (GO) were developed by an in situ synthesis in which self-assembly process was conducted to direct partial reduction of GO by chitosan in acidic medium. Physical-chemical characterization was carried out by optical microscopy (OM), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). In vitro biological studies using murine fibroblast (MC3T3) and human neuroblastoma (SH-SY5Y) cell lines were also performed...
February 9, 2018: Journal of Biomedical Materials Research. Part A
Asadullah Madni, Sobia Noreen, Irsah Maqbool, Faizza Rehman, Amna Batool, Prince Muhammad Kashif, Mubashar Rehman, Nayab Tahir, Muhammad Imran Khan
Graphene, the mother of all carbon materials has unlocked a new era of biomedical nanomaterials due to its exceptional biocompatibility, physicochemical and mechanical properties. It is a single atom thick, nanosized, 2-dimensional structure and provides high surface area with adjustable surface chemistry to form hybrids. The present article provides a comprehensive review of ever-expanding application of graphene nanomaterials with different inorganic and organic materials in drug delivery and theranostics...
February 9, 2018: Journal of Drug Targeting
Xuan Liu, Xiaozhen Cheng, Fengzhe Wang, Longbao Feng, Yu Wang, Yanfang Zheng, Rui Guo
Graphene oxide (GO) is a promising material for biomedical applications, particularly in drug delivery, due to its exceptional chemical and physical properties. In this work, an innovative GO-based carrier was developed by modifying GO with chitosan (CHI) to improve the biocompatibility, and followed by the conjugation of hyaluronic acid (HA), the target ligand for CD44, to realize the specific recognition of tumor cells and improve the efficiency of anti-tumor drug delivery. The resulting product GO-CHI-HA was loaded with an anti-cancer drug SNX-2112, which is the Hsp90 inhibitor...
April 1, 2018: Carbohydrate Polymers
Sheng-Jen Cheng, Hsien-Yi Chiu, Priyank V Kumar, Kuan Yu Hsieh, Jia-Wei Yang, You-Rong Lin, Yu-Chih Shen, Guan-Yu Chen
Graphene oxide (GO), a derivative of graphene, and its related nanomaterials have attracted much attention in recent years due to the excellent biocompatibility and large surface area of GO with abundant oxygen functional groups, which further enable it to serve as a nano-bio interface. Herein, we demonstrate the induction of blue fluorescence in GO suspensions via a mild thermal annealing procedure. Additionally, this procedure preserves the oxygen functional groups on the graphene plane which enables the conjugation of cancer drugs without obvious cytotoxicity...
February 8, 2018: Biomaterials Science
Iwona Lasocka, Lidia Szulc-Dąbrowska, Michał Skibniewski, Ewa Skibniewska, Włodzimierz Strupinski, Iwona Pasternak, Hubert Kmieć, Paweł Kowalczyk
The aim of the present study was to evaluate the cytotoxicity of pristine graphene monolayer and its utility as a scaffold for murine fibroblast L929 cell line. Cell viability, morphology, cytoskeleton architecture (microfilaments and microtubules), cell adhesion and migration into the scratch-wound area were determined using pristine graphene-coated microscopic slides. We found that fibroblasts cultured on pristine graphene monolayer exhibited changes in cell attachment, motility and cytoskeleton organization...
January 31, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Wentao Deng, Juhui Qiu, Shaoting Wang, Zhi Yuan, Yuefeng Jia, Hailin Tan, Jiru Lu, Ruqiang Zheng
In this study, we performed the characterization and synthesis of biocompatible and targeted albumin and graphene oxide (GO) dual-carrier paclitaxel (PTX) nanoparticles for photothermal-triggered tumor therapy. PTX absorbed on GO nanosheets as cores were coated with human serum albumin (HSA), following surface conjugation with monoclonal antibodies (mAb) against vascular endothelial growth factor (VEGF; denoted as mAbVEGF) via polyethylene glycol linker to form targeted nanoparticles (PTX-GHP-VEGF). The spherical nanoparticles were 191±5 nm in size with good stability and biocompatibility...
2018: International Journal of Nanomedicine
Ying Wang, Monika Mortimer, Chong Hyun Chang, Patricia A Holden
Robust evaluation of potential environmental and health risks of carbonaceous and boron nitride nanomaterials (NMs) is imperative. However, significant agglomeration of pristine carbonaceous and boron nitride NMs due to strong van der Waals forces renders them not suitable for direct toxicity testing in aqueous media. Here, the natural polysaccharide alginic acid (AA) was used as a nontoxic, environmentally relevant dispersant with defined composition to disperse seven types of carbonaceous and boron nitride NMs, including multiwall carbon nanotubes, graphene, boron nitride nanotubes, and hexagonal boron nitride flakes, with various physicochemical characteristics...
January 30, 2018: Nanomaterials
Sung-Chan Jang, Sung-Min Kang, Jun Young Lee, Seo Yeong Oh, At Ezhil Vilian, Ilsong Lee, Young-Kyu Han, Jeong Hoon Park, Wan-Seob Cho, Changhyun Roh, Yun Suk Huh
Introduction: Positron emission tomography (PET) tracers has the potential to revolutionize cancer imaging and diagnosis. PET tracers offer non-invasive quantitative imaging in biotechnology and biomedical applications, but it requires radioisotopes as radioactive imaging tracers or radiopharmaceuticals. Method: This paper reports the synthesis of 18F-nGO-PEG by covalently functionalizing PEG with nano-graphene oxide, and its excellent stability in physiological solutions...
2018: International Journal of Nanomedicine
Ahruem Baek, Yu Mi Baek, Hyung-Mo Kim, Bong-Hyun Jun, Dong-Eun Kim
Graphene oxide (GO) is known to strongly bind single-stranded nucleic acids with fluorescence quenching near the GO surface. However, GO exhibits weak biocompatibility characteristics, such as low solubility in cell culture media and significant cytotoxicity. To improve solubility in cell culture media and cell viability of GO, we prepared nano-sized GO (nGO) constructs and modified the nGO surface using polyethylene glycol (PEG-nGO). Single-stranded peptide nucleic acid (PNA) was adsorbed onto the PEG-nGO and was readily desorbed by adding complementary RNA or under low pH conditions...
January 27, 2018: Bioconjugate Chemistry
Lu Han, Honglong Sun, Pengfei Tang, Pengfei Li, Chaoming Xie, Menghao Wang, Kefeng Wang, Jie Weng, Hui Tan, Fuzeng Ren, Xiong Lu
Graphene oxide (GO) attracts considerable attention for biomedical applications owing to its unique nanostructure and remarkable physicochemical characteristics. However, it is challenging to uniformly deposit GO on chemically inert Ti scaffolds, which have good biocompatibility and wide applications in bone engineering. In this study, a GO-functionalized Ti porous scaffold (GO/Ti scaffold) was prepared by depositing GO onto polydopamine (PDA) modified Ti scaffolds. The mussel-inspired PDA modification facilitated the interaction between GO and Ti surfaces, leading to a uniform coverage of GO on Ti scaffolds...
January 29, 2018: Biomaterials Science
Wei Qian, Chang Yan, Danfeng He, Yunzhou Yu, Long Yuan, Menglong Liu, Gaoxing Luo, Jun Deng
Subcutaneous abscesses infected by multidrug-resistant bacteria are becoming an increasing challenge to human health. To address this challenge, a surface-adaptive and biocompatible glycol chitosan conjugated carboxyl graphene (GCS-CG) is developed, which exhibits unique self-adaptive target to the acidic microenvironment of abscess (∼ pH 6.3) and no damage to the healthy tissue (pH 7.4) around the abscess. Originally, following conjugated with GCS, the absorbance of CG obviously increased in the near-infrared (NIR) region, enabling GCS-CG to generate an increment amount of heat...
January 24, 2018: Acta Biomaterialia
Mariana Ioniță, Livia Elena Crică, Stefan Ioan Voicu, Sorina Dinescu, Florin Miculescu, Marieta Costache, Horia Iovu
Comparative evaluation of innovative combinations of three types of carbon nanomaterial (CNM) highlighted membranes with important potential for biomedical applications. Non-solvent induced phase separation coupled with ultrasound technique was used to generate membranes comprised of (i) cellulose acetate/ammonia functionalized carbon nanotubes (CA/CNT), (ii) cellulose acetate/ammonia functionalized graphene oxide (CA/GO), and (iii) cellulose acetate/CNT-GO. Structural, topographical and thermal features as well as water and ethanol permeation, bovine serum albumin (BSA) and haemoglobin (Hb) rejection were evaluated...
March 1, 2018: Carbohydrate Polymers
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