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Graphene biocompatibility

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https://www.readbyqxmd.com/read/28732937/dispersion-enhancing-effect-of-sonochemically-functionalized-graphene-oxide-for-catalysing-antioxidant-efficacy-of-curcumin
#1
Shrikant S Maktedar, Parth Malik, Gopal Avashthi, Man Singh
The non-hazardous sonochemical approach has been developed for the functionalization of graphene oxide (GrO) with 5-Aminoindazole (5-AIND). The formation of f-(5-AIND) GrO is confirmed with (13)C solid state NMR, HRXPS, XRD, Raman, TGA, DSC, FTIR etc. The >80% cell viabilities on MCF-7 and Vero cell lines have confirmed the high cytocompatibility of f-(5-AIND) GrO. Additionally, the morphological impact on Vero cell line has evidently confirmed the biocompatibility of f-(5-AIND) GrO. As compared to GrO, the f-(5-AIND) GrO has demonstrated an enhanced antioxidant efficacy of 69...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28726563/mechanically-strong-and-ph-responsive-carboxymethyl-chitosan-graphene-oxide-polyacrylamide-nanocomposite-hydrogels-with-fast-recoverability
#2
Yang Chen, Hongqiu Wang, Junrong Yu, Yan Wang, Jing Zhu, Zuming Hu
The biocompatible, quickly recoverable, mechanically strong and tough polymer hydrogels has great potential for biomedical applications. A novel carboxymethyl chitosan (CMCTs)/graphene oxide (GO)/polyacrylamide (PAM) nanocomposite (NC) hydrogel with excellent mechanical performance was synthesized through a facile, one-pot free radical polymerization, using GO nanosheets as the crosslink centers instead of toxic organic molecules. The content of GO nanosheets and CMCTs has great influence on the mechanical properties of CMCTs/GO/PAM NC hydrogels...
July 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28723068/biomimetic-hybridization-of-kevlar-into-silk-fibroin-nanofibrous-strategy-for-improved-mechanic-properties-of-flexible-composites-and-filtration-membranes
#3
Lili Lv, Xiangsheng Han, Lu Zong, Mingjie Li, Jun You, Xiaochen Wu, Chaoxu Li
Silk, one of the strongest natural biopolymers, was hybridized with Kevlar, one of the strongest synthetic polymers, through a biomimetic nanofibrous strategy. Regenerated silk materials have outstanding properties in transparency, biocompatibility, biodegradability and sustainability, and promised the applications as diverse as in pharmaceutics, electronics, photonic devices and membranes. To compete with super mechanic properties of their natural counterpart, regenerated silk materials have been hybridized with inorganic fillers such as graphene and carbon nanotubes, but frequently losing essential mechanic flexibility...
July 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28718622/graphene-sheet-induced-global-maturation-of-cardiomyocytes-derived-from-human-induced-pluripotent-stem-cells
#4
Jiaxian Wang, Chang Cui, Haiyan Nan, Yuanfang Yu, Yini Xiao, Ellen Poon, Gang Yang, Xijie Wang, Chenchen Wang, Lingsong Li, Kenneth Richard Boheler, Xu Ma, Xin Cheng, Zhenhua Ni, Minglong Chen
Human induced pluripotent stem cells (hiPSCs) can proliferate infinitely. Their ability to differentiate into cardiomyocytes provides abundant sources for disease modeling, drug screening and regenerative medicine. However, hiPSC-derived cardiomyocytes (hiPSC-CMs) display a low degree of maturation and fetal-like properties. Current in vitro differentiation methods do not mimic the structural, mechanical, and physiological properties of the cardiogenesis niche. Recently, we present an efficient cardiac maturation platform that combines hiPSCs monolayer cardiac differentiation with graphene substrate which is a biocompatible and superconductive material...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28711617/highly-sensitive-label-free-immunosensing-of-prostate-specific-antigen-using-poly-cysteine-caped-by-graphene-quantum-and-gold-nanoparticle-a-novel-signal-amplification-strategy
#5
Hediyeh Malekzad, Mohammad Hasanzadeh, Nasrin Shadjou, Abolghasem Jouyban
A mediator-free electrochemical immunosensor for quantitation of prostate specific antigen (PSA) based on dual signal amplification strategy was fabricated. In this work, PSA-antibody (anti-PSA) was immobilized onto a green and biocompatible nanocomposite containing poly L-cysteine (P-Cys) as conductive matrix and graphene quantum dots (GQDs)/gold nanoparticles (GNPs) as dual signal amplification elements. Therefore, a novel multilayer film based on P-Cys, GQDs, and GNPs was exploited to develop a highly sensitive amperometric immunosensor for detection of PSA...
July 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28704918/anticancer-activity-of-graphene-oxide-reduced-graphene-oxide-silver-nanoparticle-composites
#6
Thangavel Kavinkumar, Krishnamoorthy Varunkumar, Vilwanathan Ravikumar, Sellaperumal Manivannan
In the present study, a chemical route was employed to synthesize graphene oxide (GO)-reduced graphene oxide (rGO)-Ag nanoparticle (AgNP) composites from graphite and AgNO3 using vitamin C as reducing agent. Powder X-ray diffraction pattern and field emission scanning electron microscope images revealed that the AgNP were uniformly distributed on the surface of GO and rGO nanosheets. For the first time, the cytotoxicity of GO, rGO, AgNP, GO-AgNP and rGO-AgNP composites were examined against human lung cancer A549 cells using MTT assay and reported quantitatively...
July 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28689990/graphene-oxide-nanosheets-in-complex-with-cell-penetrating-peptides-for-oligonucleotides-delivery
#7
Moataz Dowaidar, Hani Nasser Abdelhamid, Mattias Hällbrink, Xiaodong Zou, Ülo Langel
A new strategy for gene transfection using the nanocarrier of cell penetrating peptides (CPPs; PepFect14 (PF14) or PepFect14 (PF14) (PF221)) in complex with graphene oxide (GO) is reported. GO complexed with CPPs and plasmid (pGL3), splice correction oligonucleotides (SCO) or small interfering RNA (siRNA) are performed. Data show adsorption of CPPs and oligonucleotides on the top of the graphenic lamellar without any observed change of the particle size of GO. GO mitigates the cytotoxicity of CPPs and improves the material biocompatibility...
July 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28685628/bacteriomimetic-poly-%C3%AE-glutamic-acid-surface-coating-for-hemocompatibility-and-safety-of-nanomaterials
#8
Gayong Shim, Dongyoon Kim, Jinyoung Kim, Min Sung Suh, Youn Kyu Kim, Yu-Kyoung Oh
Poly-γ-glutamic acid (PGA), a major component of the bacterial capsule, is known to confer hydrophilicity to bacterial surfaces and protect bacteria from interactions with blood cells. We tested whether applying a bacteriomimetic surface coating of PGA modulates interactions of nanomaterials with blood cells or affects their safety and photothermal antitumor efficacy. Amphiphilic PGA (APGA), prepared by grafting phenylalanine residues to PGA, was used to anchor PGA to reduced graphene oxide (rGO) nanosheets, a model of hydrophobic nanomaterials...
July 7, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28675929/red-yellow-and-blue-luminescence-by-graphene-quantum-dots-syntheses-mechanism-and-cellular-imaging
#9
Tian Gao, Xi Wang, Li-Yun Yang, Huan He, Xiao-Xu Ba, Jie Zhao, Feng-Lei Jiang, Yi Liu
Owing to their excellent photoluminescence (PL) properties, good biocompatibility, and low toxicity, graphene quantum dots (GQDs) are widely applied in bioimaging, biosensing, and so forth. However, further development of GQDs is limited by their synthetic methodology and unclear PL mechanism. Therefore, it is urgent to find efficient and universal methods for the synthesis of GQDs with high stability, controllable surface properties, and tunable PL emission wavelength. By coating with polyethyleneimine (PEI) of different molecular weights, blue-, yellow-, and red-emitting GQDs were successfully prepared...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28663938/microplasma-assisted-hydrogel-fabrication-a-novel-method-for-gelatin-graphene-oxide-nano-composite-hydrogel-synthesis-for-biomedical-application
#10
Mantosh Kumar Satapathy, Wei-Hung Chiang, Er-Yuan Chuang, Chih-Hwa Chen, Jia-Liang Liao, Huin-Ning Huang
Toxicity issues and biocompatibility concerns with traditional classical chemical cross-linking processes prevent them from being universal approaches for hydrogel fabrication for tissue engineering. Physical cross-linking methods are non-toxic and widely used to obtain cross-linked polymers in a tunable manner. Therefore, in the current study, argon micro-plasma was introduced as a neutral energy source for cross-linking in fabrication of the desired gelatin-graphene oxide (gel-GO) nanocomposite hydrogel scaffolds...
2017: PeerJ
https://www.readbyqxmd.com/read/28662392/mc3t3-e1-pre-osteoblast-response-and-differentiation-after-graphene-oxide-nanosheet-uptake
#11
Mónica Cicuéndez, Virgília S Silva, María J Hortigüela, M Concepción Matesanz, Mercedes Vila, M Teresa Portolés
Nano-graphene oxide (GO) and its functionalized derivatives have aroused a great interest for drug delivery, tissue engineering and photothermal cancer therapy, but their biocompatibility has not yet been fully assessed. The aim of the present study was to evaluate the proliferation and differentiation of MC3T3-E1 pre-osteoblasts after the uptake of GO nanosheets (c.a. 400nm), functionalized with poly(ethylene glycol-amine) (PEG) and labelled with fluorescein isothiocyanate (FITC). Significant proliferation decrease and apoptosis increase were observed 3days after incorporation of FITC-PEG-GO by MC3T3-E1 cells...
June 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28656906/polydopamine-functionalized-nanographene-oxide-a-versatile-nanocarrier-for-chemotherapy-and-photothermal-therapy
#12
Xinyuan Zhang, Xu Nan, Wei Shi, Yanan Sun, Huiling Su, Yuan He, Xin Liu, Zhong Zhang, Dongtao Ge
For releasing both drug and heat to selected sites, a combination of chemotherapy and photothermal therapy in one system is a more effective way to destroy cancer cells than monotherapy. Graphene oxide (GO) with high drug-loading efficiency and near-infrared (NIR) absorbance has great potential in drug delivery and photothermal therapy, but it is difficult to load drugs with high solubility. Herein, we develop a versatile drug delivery nanoplatform based on GO for integrated chemotherapy and photothermal therapy by a facile method of simultaneous reduction and surface functionalization of GO with poly(dopamine) (PDA)...
June 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28654127/bio-camouflage-of-anatase-nanoparticles-explored-by-in-situ-high-resolution-electron-microscopy
#13
Ana R Ribeiro, Arijita Mukherjee, Xuan Hu, Shayan Shafien, Reza Ghodsi, Kun He, Sara Gemini-Piperni, Canhui Wang, Robert F Klie, Tolou Shokuhfar, Reza Shahbazian-Yassar, Radovan Borojevic, Luis A Rocha, José M Granjeiro
While titanium is the metal of choice for most prosthetics and inner body devices due to its superior biocompatibility, the discovery of Ti-containing species in the adjacent tissue as a result of wear and corrosion has been associated with autoimmune diseases and premature implant failures. Here, we utilize the in situ liquid cell transmission electron microscopy (TEM) in a liquid flow holder and graphene liquid cells (GLCs) to investigate, for the first time, the in situ nano-bio interactions between titanium dioxide nanoparticles and biological medium...
June 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28652737/development-of-graphene-oxide-wrapped-gold-nanorods-as-robust-nanoplatform-for-ultrafast-near-infrared-sers-bioimaging
#14
Xuejun Qiu, Xinru You, Xing Chen, Haolin Chen, Arvind Dhinakar, Songhao Liu, Zhouyi Guo, Jun Wu, Zhiming Liu
The rapid development of near-infrared surface-enhanced Raman scattering (NIR SERS) imaging technology has attracted strong interest from scientists and clinicians due to its narrow spectral bandwidth, low background interference, and deep imaging depth. In this report, the graphene oxide (GO)-wrapped gold nanorods (GO@GNRs) were developed as a smart and robust nanoplatform for ultrafast NIR SERS bioimaging. The fabricated GO@ GNRs could efficiently load various NIR probes, and the in vitro evaluation indicated that the nanoplatform could exhibit a higher NIR SERS activity in comparison with traditional gold nanostructures...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28652728/ti-go-ag-nanocomposite-the-effect-of-content-level-on-the-antimicrobial-activity-and-cytotoxicity
#15
Jianfeng Jin, Li Zhang, Mengqi Shi, Yumei Zhang, Qintao Wang
Surface modification of titanium (Ti) implants are extensively studied in order to obtain prominent biocompatibility and antimicrobial activity, especially preventing implant-associated infection. In this study, Ti substrates surface were modified by graphene oxide (GO) thin film and silver (Ag) nanoparticles via electroplating and ultraviolet reduction methods so as to achieve this purpose. Microstructures, distribution, quantities and spectral peaks of GO and Ag loading on the Ti sheets surface were characterized...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28650635/ternary-interactions-and-energy-transfer-between-fluorescein-isothiocyanate-adenosine-triphosphate-and-graphene-oxide-nanocarriers
#16
Katarzyna Ratajczak, Magdalena Stobiecka
The interactions of fluorescent probes and biomolecules with nanocarriers are of key importance to the emerging targeted drug delivery systems. Graphene oxide nanosheets (GONs) as the nanocarriers offer biocompatibility and robust drug binding capacity. The interactions of GONs with fluorophores lead to strong fluorescence quenching, which may interfere with fluorescence bioimaging and biodetection. Herein, we report on the interactions and energy transfers in a model ternary system: GONs-FITC-ATP, where FITC is a model fluorophore (fluorescein isothiocyanate) and ATP is a common biomolecule (adenosine-5'-triphosphate)...
July 5, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28640986/antimonene-quantum-dots-synthesis-and-application-as-near-infrared-photothermal-agents-for-effective-cancer-therapy
#17
Wei Tao, Xiaoyuan Ji, Xiaoding Xu, Mohammad Ariful Islam, Zhongjun Li, Si Chen, Phei Er Saw, Han Zhang, Zameer Bharwani, Zilei Guo, Jinjun Shi, Omid Farokhzad
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28629070/fabrication-of-chitosan-graphene-oxide-polymer-nanofiber-and-its-biocompatibility-for-cartilage-tissue-engineering
#18
Lei Cao, Fei Zhang, Qiugen Wang, Xiaofeng Wu
In this work, Chitosan/Poly(vinyl alcohol) (PVA)/graphene oxide (GO) composite nanofibers were fabricated by electrospinning technique. The prepared nanofibers were characterized by using various spectroscopic and microscopic techniques. FESEM images have confirmed the uniform distributions of graphene oxide nanosheets in the nanofibers with self-assembly with chitosan/PVA chains. Additionally, the results of raman spectra confirmed the existence of GO sheets in the nanofibers. The tensile strength experiments revealed that the incorporation of GO increased the mechanical properties of nanofibers...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629024/electrospun-silk-fibroin-scaffolds-coated-with-reduced-graphene-promote-neurite-outgrowth-of-pc-12-cells-under-electrical-stimulation
#19
Salvador Aznar-Cervantes, Ana Pagán, Jose G Martínez, Antonia Bernabeu-Esclapez, Toribio F Otero, Luis Meseguer-Olmo, Juan I Paredes, Jose L Cenis
Novel approaches to neural research require biocompatible materials capable to act as electrode structures or scaffolds for tissue engineering in order to stimulate or restore the functionality of damaged tissues. This work offers promising results that indicate the potential use of electrospun silk fibroin (SF) scaffolds coated with reduced graphene oxide (rGO) in this sense. The coated material becomes conductor and electroactive. A complete characterisation of SF/rGO scaffolds is provided in terms of electrochemistry, mechanical behaviour and chemical conformation of fibroin...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629019/methotrexate-loaded-nitrogen-doped-graphene-quantum-dots-nanocarriers-as-an-efficient-anticancer-drug-delivery-system
#20
Fatemeh Khodadadei, Shahrokh Safarian, Narges Ghanbari
Graphene quantum dots (GQDs) are new efficient nanomaterials used in therapeutic applications. In this study, blue fluorescent nitrogen-doped GQDs (N-GQDs) were synthesized by a hydrothermal method via pyrolisis of citric acid as the carbon source and urea as the nitrogen source. The existence of doped nitrogen in GQDs was confirmed by FTIR characterization. Here, for the first time, the N-GQDs were loaded with the anticancer drug, methotrexate (MTX), to prepare MTX-(N-GQDs) as an efficient drug delivery system...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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