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Graphene biocompatibility

Xiuming Bu, Jipeng Li, Siwei Yang, Jing Sun, Yuan Deng, Yucheng Yang, Gang Wang, Zheng Peng, Peng He, Xianying Wang, Guqiao Ding, Junhe Yang, Xiaoming Xie
We developed a universal method to prepare hydrophilic carbon nitrogen (C3N4) nanosheets. By treating C3N4 nanosheets with oxygen plasma, hydroxylamine groups (N-OH) with intense protonation could be introduced on the surface, moreover, the content of N-OH groups increased linearly with the oxygen plasma treating time. Thanks to the excellent hydrophilicity, uniformly dispersed C3N4 solution were prepared, which was further translated into C3N4 paper by simple vacuum filtration. Pure C3N4 paper with good stability, excellent hydrophilicity and biocompatibility were proved to have excellent performance in tissue repair...
October 21, 2016: ACS Applied Materials & Interfaces
Jie Li, Hongkun Jiang, Xiao Ouyang, Shihui Han, Jun Wang, Rui Xie, Wenting Zhu, Ning Ma, Hao Wei, Zhongyi Jiang
CaCO3 is one kind of important biological mineral, which widely exists in coral, shell and other organisms. Since similar to bone tissue elements and good biocompatibility, it was very suitable for candidates as bone drug carriers. In this paper, we used tetraethylenepentamine-graphene (rGO-TEPA) sheet matrices induction of CaCO3 mineralization and successfully constructed CaCO3/rGO-TEPA drug carriers with a hollow structure and rough surface. As potential drug carriers, doxorubicin (DOX) loading and release measurements were carried out...
October 18, 2016: ACS Applied Materials & Interfaces
Peng Yu, Rui-Ying Bao, Xiao-Jun Shi, Wei Yang, Ming-Bo Yang
Graphene hydrogel has shown greatly potentials in bone tissue engineering recently, but it is relatively weak in the practical use. Here we report a facile method to synthesize high strength composite graphene hydrogel. Graphene oxide (GO), hydroxyapatite (HA) nanoparticles (NPs) and chitosan (CS) self-assemble into a 3-dimensional hydrogel with the assistance of crosslinking agent genipin (GNP) for CS and reducing agent sodium ascorbate (NaVC) for GO simultaneously. The dense and oriented microstructure of the resulted composite gel endows it with high mechanical strength, high fixing capacity of HA and high porosity...
January 2, 2017: Carbohydrate Polymers
Mona Alibolandi, Marzieh Mohammadi, Seyed Mohammad Taghdisi, Mohammad Ramezani, Khalil Abnous
In the current study, dextran (DEX) was covalently conjugated to the surface of nano-GO sheets, making stable biocompatible dextran coated GO (GO-DEX). The prepared GO-DEX was nontoxic to 4T1 mammary carcinoma cell line at concentrations up to 300μg/mL. AS1411 aptamer, a ssDNA aptamer which can improve the intracellular uptake by nucleolin recognition, also has been introduced to hydroxyl groups of DEX in GO-DEX to produce GO-DEX-Apt. Moreover, curcumin (CUR), a natural polyphenol, found in the rhizomes of Curcuma longa (turmeric) which shows antineoplastic effects, was loaded onto the GO-DEX and GO-DEX-Apt via π-π stacking interactions with a high loading capacity (∼29wt%)...
January 2, 2017: Carbohydrate Polymers
Jiaxi Wang, Jie Li, Yanan Wang, Mingxia Gao, Xiangmin Zhang, Pengyuan Yang
Protein N-glycosylation is a ubiquitous and important post-translational modification that has been involved in the development and progression of a series of human-related diseases. Until recently, the highly selective capturing of glycopeptides from complex biosamples was still significant and challenging work due to their changeable structures, ultralow abundance, and strong ion-suppressing effect. Here we first report the preparation and characterization of a novel, hydrophilic, porous biocomposite composed of magnetic graphene functionalized with metal-organic frameworks (MOFs) (MG@Zn-MOFs) able to recognize glycopeptides...
October 6, 2016: ACS Applied Materials & Interfaces
Haizhu Lin, Chunhui Deng
In this work, we first immobilized tin(IV) ion on polydopamine-coated magnetic graphene (magG@PDA) to synthesize Sn(4+) -immobilized magG@PDA (magG@PDA-Sn(4+) ) and successfully applied the material to highly selective enrichment of phosphopeptides. The material gathered the advantages of large surface area of graphene, superparamagnetism of Fe3 O4 , good hydrophilicity and biocompatibility of polydopamine and the strong interaction between Sn(4+) and phosphopeptides. The enrichment performance of magG@PDA-Sn(4+) toward phosphopeptides from digested β-casein at different concentrations, with and without added digested BSA (bovine serum albumin) was investigated and compared with magG@PDA-Ti(4+) ...
September 21, 2016: Proteomics
Arnab Halder, Minwei Zhang, Qijin Chi
Design and synthesis of low-cost, highly stable, electroactive and biocompatible material is one of the key steps for the advancement of electrochemical biosensing systems. To this end, we have explored a facile way for the successful synthesis of redox active and bioengineering of reduced graphene oxide (RGO) for the development of versatile biosensing platform. A highly branched polymer (PEI) is used for reduction and simultaneous derivation of graphene oxide (GO) to form a biocompatible polymeric matrix on RGO nanosheet...
September 9, 2016: Biosensors & Bioelectronics
Mingdang Li, Ping Wang, Faying Li, Qingyan Chu, Yueyun Li, Yunhui Dong
Herein, a novel and sensitive sandwich-type electrochemical immunosensor was fabricated for quantitative monitoring of prostate specific antigen (PSA). The sulfo group functionalized multi-walled carbon nanotubes (MWCNTs-SO3H) were used as substrate material to increase the specific surface area and enhance the conductivity of the glassy carbon electrode. Gold nanoparticles (Au NPs) were introduced to enhance the load capacity of the substrate material for primary antibodies (Ab1) and accelerate the electron transfer on the electrode interface...
August 24, 2016: Biosensors & Bioelectronics
Ali H Palejwala, Jared S Fridley, Javier A Mata, Errol L G Samuel, Thomas G Luerssen, Laszlo Perlaky, Thomas A Kent, James M Tour, Andrew Jea
BACKGROUND: Graphene has unique electrical, physical, and chemical properties that may have great potential as a bioscaffold for neuronal regeneration after spinal cord injury. These nanoscaffolds have previously been shown to be biocompatible in vitro; in the present study, we wished to evaluate its biocompatibility in an in vivo spinal cord injury model. METHODS: Graphene nanoscaffolds were prepared by the mild chemical reduction of graphene oxide. Twenty Wistar rats (19 male and 1 female) underwent hemispinal cord transection at approximately the T2 level...
2016: Surgical Neurology International
Phitsini Suvarnaphaet, Chandra Sekhar Tiwary, Jutaphet Wetcharungsri, Supanit Porntheeraphat, Rassmidara Hoonsawat, Pulickel Madhavapanicker Ajayan, I-Ming Tang, Piyapong Asanithi
Carbon-based photoluminescent nanodot has currently been one of the promising materials for various applications. The remaining challenges are the carbon sources and the simple synthetic processes that enhance the quantum yield, photostability and biocompatibility of the nanodots. In this work, the synthesis of blue photoluminescent carbon nanodots from limeade via a single-step hydrothermal carbonization process is presented. Lime carbon nanodot (L-CnD), whose the quantum yield exceeding 50% for the 490nm emission in gram-scale amounts, has the structure of graphene core functionalized with the oxygen functional groups...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Bo Wang, Young Sil Jeon, Ho Seok Park, Ji-Heung Kim
Stimuli-responsive and self-healing materials have a wide range of potential uses, and some significant research has focused on cross-linking of hydrogel materials by means of reversible coordination bonding. The resulting materials, however, tend to have poor mechanical properties with pronounced weakness and brittleness. In this work, we present a novel mussel-inspired graphene oxide(GO)-containing hydrogel based on modified polyaspartamide with γ-amino butyric acid (GABA), 3.4-dihydroxyphenethylamine (DOPA), and ethanolamine (EA), termed PolyAspAm(GABA/DOPA/EA)...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Gururaj M Neelgund, Aderemi R Oki
Herein we present a successful strategy for enhancement of photothermal efficiency of hydroxyapatite (HAP) by its conjugation with carbon nanotubes (CNTs) and graphene nanosheets (GR). Owing to excellent biocompatibility with human body and its non-toxicity, implementation of HAP based nanomaterials in photothermal therapy (PTT) provides non-replaceable benefits over PTE agents. Therefore, in this report, it has been experimentally exploited that the photothermal effect (PTE) of HAP has significantly improved by its assembly with CNTs and GR...
December 15, 2016: Journal of Colloid and Interface Science
Kasturi Muthoosamy, Ibrahim Babangida Abubakar, Renu Geetha Bai, Hwei-San Loh, Sivakumar Manickam
Metastasis of lung carcinoma to breast and vice versa accounts for one of the vast majority of cancer deaths. Synergistic treatments are proven to be the effective method to inhibit malignant cell proliferation. It is highly advantageous to use the minimum amount of a potent toxic drug, such as paclitaxel (Ptx) in ng/ml together with a natural and safe anticancer drug, curcumin (Cur) to reduce the systemic toxicity. However, both Cur and Ptx suffer from poor bioavailability. Herein, a drug delivery cargo was engineered by functionalizing reduced graphene oxide (G) with an amphiphilic polymer, PF-127 (P) by hydrophobic assembly...
2016: Scientific Reports
Maria Iliut, Claudio Silva, Scott Herrick, Mark McGlothlin, Aravind Vijayaraghavan
Thin-film elastomers (elastic polymers) have a number of technologically significant applications ranging from sportswear to medical devices. In this work, we demonstrate that graphene can be used to reinforce 20 micron thin elastomer films, resulting in over 50% increase in elastic modulus at a very low loading of 0.1 wt%, while also increasing the elongation to failure. This loading is below the percolation threshold for electrical conductivity. We demonstrate composites with both graphene oxide and reduced graphene oxide, the reduction being undertaken in-situ or ex-situ using a biocompatible reducing agent in ascorbic acid...
September 2016: Carbon
Hui Liu, Kai Guo, Congyue Duan, Xiaonan Dong, Jiaojiao Gao
Hollow TiO2 modified reduced graphene oxide microspheres (hollow TiO2-rGO microspheres or H-TiO2-rGO MS) have been synthesized and then be used to immobilize hemoglobin (Hb) to fabricate a mediator-free biosensor. The morphology and structure of hollow TiO2-rGO microspheres were characterized by scanning electron microscopy, transmission electronic microscopy and X-ray diffraction. Results of spectroscopy and electrochemistry tests revealed that hollow TiO2-rGO microsphere is an excellent immobilization matrix with biocompatibility for redox protein, affording good protein bioactivity and stability...
August 30, 2016: Biosensors & Bioelectronics
Ziyun Jiang, Qin Song, Mingliang Tang, Lingyan Yang, Yilin Cheng, Min Zhang, Dongsheng Xu, Guosheng Cheng
One of the key challenges in engineering neural tissues for cell-based therapies is to develop a biocompatible scaffold material to direct neural stem cell (NSC) behaviors. One great advantage for a scaffold would be to induce NSC migration toward pathological sites during regeneration and repair. In particular, the inflammatory responses in the pathological zone, which are mainly mediated by microglia in the central nervous system, affect the repair capacity of NSCs through NSC migration. Recently, graphene was used as a neural interface and scaffold material, but few studies have addressed the relationship between microglia and NSCs in a graphene culture system...
September 28, 2016: ACS Applied Materials & Interfaces
Dibyendu Chakravarty, Chandra Sekhar Tiwary, Cristano F Woellner, Sruthi Radhakrishnan, Soumya Vinod, Sehmus Ozden, Pedro Alves da Silva Autreto, Sanjit Bhowmick, Syed Asif, Sendurai A Mani, Douglas S Galvao, Pulickel M Ajayan
3D scaffolds of graphene, possessing ultra-low density, macroporous microstructure, and high yield strength and stiffness can be developed by a novel plasma welding process. The bonding between adjacent graphene sheets is investigated by molecular dynamics simulations. The high degree of biocompatibility along with high porosity and good mechanical properties makes graphene an ideal material for use as body implants.
August 26, 2016: Advanced Materials
Feng Zhou, Liming Chen, Qingzhu An, Liang Chen, Ying Wen, Fang Fang, Wei Zhu, Tao Yi
We report a novel graphene-oxide (GO) enhanced polymer hydrogel (GPH) as a promising embolic agent capable of treating cerebrovascular diseases and malignant tumors, using the trans-catheter arterial embolization (TAE) technique. Simply composed of GO and generation five poly(amidoamine) dendrimers (PAMAM-5), our rheology experiments reveal that GPH exhibits satisfactory mechanical strength, which resist the high pressures of blood flow. Subcutaneous experiments on Sprague-Dawley (SD) rats demonstrate the qualified biocompatibility of GPH...
2016: Scientific Reports
Mingxiang Ji, Han Li, Hailin Guo, Anjian Xie, Shaohua Wang, Fangzhi Huang, Shikuo Li, Yuhua Shen, Jiacai He
A novel porous graphene oxide (GO)/chitosan (CTS)-hydroxyapatite (HA) nanocomposite film was successfully prepared for the first time by combining layer-by-layer (LBL) assembly technology with biomimetic mineralization method. The LBL technology was used to control the thickness of film as well as induce the biomimetic mineralization of biocompatible HA. The obtained (GO/CTS-HA)n film provided ideal platform for the proliferation of mouse mesenchymal stem cells (mMSCs). The pore size in the film is about 300nm, and the porous architecture made the film have high aspirin loading efficiency...
November 20, 2016: Carbohydrate Polymers
Zhong Li, Nay Win Khun, Xiu-Zhi Tang, Erjia Liu, Khiam Aik Khor
45S5 Bioglass(®) (45S5) is one of the most widely used biomaterials in ceramic-based bone graft substitutes by virtue of its excellent biocompatibility and bioactivity. However, the fracture toughness and wear resistance of 45S5 have to be improved to extend its applications in load bearing orthopedic implants. The current study reports the first use of graphene nanoplatelet (GNP) to enhance the fracture toughness and wear resistance of 45S5. Composite powders with four different loadings of graphene oxide (GO), i...
August 6, 2016: Journal of the Mechanical Behavior of Biomedical Materials
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