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Graphene biocompatibility

Yibiao Liu, Li-Ping Xu, Qiang Wang, Baocheng Yang, Xueji Zhang
Inhibiting the amyloid aggregation is considered to be an effective strategy to explore possible treatment of amyloid-related diseases including Alzheimer's disease, Parkinson's disease, and type II diabetes. Herein, a new high-efficiency and low-cytotoxicity Aβ aggregation inhibitors, GQD-T was designed through the combination of two Aβ inhibitors graphene quantum dots (GQDs) and tramiprosate. GQD-T showed the capability of efficiently inhibiting the aggregation of Aβ peptides and rescuing Aβ-induced cytotoxicity due to the synergistic effect of the GQDs and tramiprosate...
December 15, 2017: ACS Chemical Neuroscience
Yuzhang Du, Juan Ge, Yannan Li, Peter X Ma, Bo Lei
Artificial muscle-like biomaterials have gained tremendous interests owing to their broad applications in regenerative medicine, wearable devices, bioelectronics and artificial intelligence. Unfortunately, key challenges are still existed for current materials, including biomimetic viscoelasticity, biocompatibility and biodegradation, multifunctionality. Herein, for the first time, we develop highly elastomeric, conductive and biodegradable poly (citric acid-octanediol-polyethylene glycol)(PCE)-graphene (PCEG) nanocomposites, and demonstrate their applications in myogenic differentiation and guiding skeletal muscle tissue regeneration...
December 6, 2017: Biomaterials
Xin Fan, Fan Yang, Chuanxiong Nie, Ye Yang, Haifeng Ji, Chao He, Chong Cheng, Changsheng Zhao
Pathogenic bacterial infection has been becoming as a global threat towards people's health, especially the massive usage of antibiotics due to the lack of antibacterial agents with less side-effects. Developing new nano-agents to fight pathogenic bacteria has provided enormous new possibilities in the treatment of bacterial infections, such as the graphene based 2D antibacterial nano-agents with different bacterial inhibition capabilities; however, mussel-inspired design of NIR-responsive and biocompatible Ag-graphene nano-agents possessed with efficient and versatile bacterial disinfection activities have rarely been reported...
December 13, 2017: ACS Applied Materials & Interfaces
Mohammad Javadi, Qi Gu, Sina Naficy, Syamak Farajikhah, Jeremy M Crook, Gordon G Wallace, Stephen Beirne, Simon E Moulton
Biocompatible conductive tough hydrogels represent a new class of advanced materials combining the properties of tough hydrogels and biocompatible conductors. Here, a simple method, to achieve a self-assembled tough elastomeric composite structure that is biocompatible, conductive, and with high flexibility, is reported. The hydrogel comprises polyether-based liner polyurethane (PU), poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(4-styrenesulfonate) (PSS), and liquid crystal graphene oxide (LCGO)...
December 13, 2017: Macromolecular Bioscience
P Arriagada, H Palza, P Palma, M Flores, P Caviedes
Poly(lactic acid) (PLA) is a biodegradable and biocompatible polyester widely used in biomedical applications. Unfortunately, this biomaterial suffers from some shortcomings related with the absence of both bioactivity and antibacterial capacity. In this work, composites of PLA with either graphene oxide (GO) or thermally reduced graphene oxide (TrGO) were prepared by melt mixing to overcome these limitations. PLA composites with both GO and TrGO inhibited the attachment and proliferation of E. coli and S. aureus bacteria depending on the kind and amount of filler...
December 8, 2017: Journal of Biomedical Materials Research. Part A
Ping-Ching Wu, Jiu-Yao Wang, Wen-Lung Wang, Chia-Yuan Chang, Chia-Hung Huang, Kun-Lin Yang, Jui-Cheng Chang, Chih-Li Lilian Hsu, Shih-Yao Chen, Ting-Mao Chou, Wen-Shuo Kuo
Nitrogen-doped graphene quantum dot (N-GQD) nanomaterials conjugated with polyethylenimine (PEI)-polystyrene sulfonate (PSS)-anti-epidermal growth factor receptor (AbEGFR) antibody (N-GQD-PEI-PSS-AbEGFR) demonstrated impressive two-photon properties and stability, signifying that they can serve as an effective two-photon contrast agent in two-photon bioimaging. Furthermore, they provided high intensity, brightness, and signal-to-noise ratios at an ultra-low two-photon excitation (TPE) power level in an observation extending to a deep, three-dimensional depth...
December 6, 2017: Nanoscale
Yonghui Zhang, Zhen Li, Chun Chan, Jiale Ma, Chunyi Zhi, Xiaolin Cheng, Jun Fan
Boron nitride nanosheets are novel promising nanomaterials with a lower cytotoxicity than graphene making them a better candidate for biomedical applications. However, there is no systematic study on how they interact with cell membranes. Here we employed large scale all-atom molecular dynamics simulations to provide molecular details of the structure and properties of membranes after the insertion of boron nitride nanosheets. Our results reveal that the boron nitride nanosheet can extract phospholipids from the lipid bilayers and is enveloped by the membrane...
December 4, 2017: Physical Chemistry Chemical Physics: PCCP
Kenry, Wong Cheng Lee, Kian Ping Loh, Chwee Teck Lim
Recent advances in stem cell research and nanotechnology have significantly influenced the landscape of tissue engineering and regenerative medicine. Precise and reproducible control of the fate of stem cells and their lineage specification have, therefore, become more crucial than ever for the success of stem cell-based technologies. Extensive research has been geared towards developing materials that are capable of mimicking the physiological microenvironment of stem cells and at the same time, controlling their eventual fate...
October 4, 2017: Biomaterials
Balaji Murugesan, Jegatheeswaran Sonamuthu, Nithya Pandiyan, Boomi Pandi, Selvam Samayanan, Sundrarajan Mahalingam
In this work, we report the fabrication of green fluorescent reduced graphene oxide quantum dots (rGOQDs) from the latex of Calotropis gigantea by simple one-step microwave assisted greener route. The latex of Calotropis gigantea calcined at 300°C and its ethanolic extract is used for the synthesis of QDs, The rGOQDs showed particle size ranging from 2 to 8nm and it exhibited green fluorescent in longer UV region at 360-520nm. The rGOQDs graphitic nature was confirmed by RAMAN and XRD analysis. The FTIR, XPS demonstrate that presence of functional groups such as CO, COC, -OH, hence it's addressing them as rGOQDs...
November 24, 2017: Journal of Photochemistry and Photobiology. B, Biology
Chuan Fu, Haotian Bai, Jiaqi Zhu, Zhihao Niu, Yu Wang, Jianan Li, Xiaoyu Yang, Yunshen Bai
One of the goals of bone tissue engineering is to mimic native ECM in architecture and function, creating scaffolds with excellent biocompatibility, osteoinductive ability and mechanical properties. The aim of this study was to fabricate nanofibrous matrices by electrospinning a blend of poly (L-lactic-co-glycolic acid) (PLGA), hydroxyapatite (HA), and grapheme oxide (GO) as a favourable platform for bone tissue engineering. The morphology, biocompatibility, mechanical properties, and biological activity of all nanofibrous matrices were compared...
2017: PloS One
Gilad Kaufman, Karla A Montejo, Arthur Michaut, Pawel W Majewski, Chinedum O Osuji
Fluid compartmentalization by micro-encapsulation is important in scenarios where protection or controlled release of encapsulated species, or isolation of chemical transformations are central concerns. Realizing responsive encapsulation systems by incorporating functional nanomaterials is of particular interest. We report here on the development of graphene oxide microcapsules enabled by a single-step microfluidic process. Interfacial reaction of epoxide-bearing graphene oxide sheets and an amine-functionalized macromolecular silicone fluid creates a chemically crosslinked film with micron-scale thickness at the surface of water-in-oil droplets generated by microfluidic devices...
November 27, 2017: ACS Applied Materials & Interfaces
Ying Cheng, Megharaj Mallavarapu, Ravi Naidu, Zuliang Chen
Improving the anode configuration to enhance biocompatibility and accelerate electron shuttling is critical for efficient energy recovery in microbial fuel cells (MFCs). In this paper, green reduced graphene nanocomposite was successfully coated using layer-by-layer assembly technique onto carbon brush anode. The modified anode achieved a 3.2-fold higher power density of 33.7 W m(-3) at a current density of 69.4 A m(-3) with a 75% shorter start period. As revealed in the characterization, the green synthesized nanocomposite film affords larger surface roughness for microbial colonization...
November 13, 2017: Chemosphere
Mina Sattari, Marziyeh Fathi, Mansour Daei, Hamid Erfan-Niya, Jaleh Barar, Ali Akbar Entezami
Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-responsive materials, poly (N-isopropylacrylamide) (PNIPAAm) based hydrogels have been widely developed and their properties can be easily tailored by manipulating the properties of the hydrogel and the composite material...
2017: BioImpacts: BI
Mukesh Kumar Kumawat, Mukeshchand Thakur, Raju B Gurung, Rohit Srivastava
We report a simple one-pot microwave assisted "green synthesis" of Graphene Quantum Dots (GQDs) using grape seed extract as a green therapeutic carbon source. These GQDs readily self-assemble, hereafter referred to as "self-assembled" GQDs (sGQDs) in the aqueous medium. The sGQDs enter via caveolae and clathrin-mediated endocytosis and target themselves into cell nucleus within 6-8 h without additional assistance of external capping/targeting agent. The tendency to self-localize themselves into cell nucleus also remains consistent in different cell lines such as L929, HT-1080, MIA PaCa-2, HeLa, and MG-63 cells, thereby serving as a nucleus labelling agent...
November 20, 2017: Scientific Reports
Ying Chen, Yu Li, Dongmei Deng, Haibo He, Xiaoxia Yan, Zhenxin Wang, Chunhai Fan, Liqiang Luo
A novel and sensitive sandwich immunosensor for amperometric determination of carcinoembryonic antigen (CEA) was designed using Au nanoparticles-titanium dioxide-graphene (AuNPs-TiO2-graphene) nanocomposites. Dopamine-functionalized graphene was firstly prepared by π-stacking interaction, and TiO2 was then attached to the surface of dopamine-graphene by the specificity and high affinity of enediol ligands to Ti (IV). Afterwards, AuNPs-TiO2-graphene nanocomposites were synthesized with photo-reduction approach under ultraviolet irradiation...
November 17, 2017: Biosensors & Bioelectronics
Chen Dai, Yu Chen, Xiangxiang Jing, Lihua Xiang, Dayang Yang, Han Lin, Zhuang Liu, Xiaoxia Han, Rong Wu
MXenes, an emerging family of graphene-analogues two-dimensional (2D) materials, have attracted continuous and tremendous attentions in many application fields because of their intrinsic physiochemical properties and high performance in versatile applications. In this work, we report on the construction of tantalum carbide (Ta4C3) MXene-based composite nanosheets for multiple imaging-guided photothermal tumor ablation, which has been achieved by rational choice of the composition of MXenes and their surface functionalization...
November 20, 2017: ACS Nano
Samira Kargar, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou, Seied Rabi Mahdavi
Glioma is one of the most common malignant cancers of the central nervous system (CNS). Radiatherapy and chemotherapy may be used to slow the growth of tumors that cannot be removed with surgery. The current study developed a combination therapy tool using Nanographene oxide (NGO) functionalized with poly lactic-co-glycolic acid (PLGA) as a carrier of 5-iodo-2-deoxyuridine (IUdR) for glioma cancer treatment. U87MG cells were treated in different groups with IUdR, PLGA-coated Nanographene oxide (PLGA-NGO), IUdR-loaded PLGA-coated Nanographene oxide (IUdR-PLGA-NGO), 2Gy 6MV X-ray radiation, and near-infrared region (NIR) laser radiation...
November 16, 2017: Photodiagnosis and Photodynamic Therapy
P R Sivashankari, A Moorthi, K Mohamed Abudhahir, M Prabaharan
Hydroxypropyl chitosan (HPCH), a water soluble derivative of chitosan, is widely considered for tissue engineering and wound healing applications due to its biocompatibility and biodegradability. Graphene oxide (GO) is a carbon-based nanomaterial which is capable of imparting desired properties to the scaffolds. Hence, the integration of GO into HPCH could allow for the production of HPCH-based scaffolds with improved swelling character, mechanical strength, and stability aimed at being used in tissue engineering...
November 14, 2017: International Journal of Biological Macromolecules
Zengqiang Gao, Yueyun Li, Xiaobo Zhang, Jinhui Feng, Ling Kong, Ping Wang, Zhiwei Chen, Yunhui Dong, Qin Wei
A sensitive sandwich-type electrochemical immunosensor for the detection of hepatitis B e antigen (HBeAg) was successfully developed based on the gold@palladium nanoparticles (Au@Pd NPs) loaded by molybdenum disulfide functionalized multiwalled carbon nanotubes (Au@Pd/MoS2@MWCNTs). The resultant nanocomposites not only possessed high specific surface area and good biocompatibility, but also exhibited excellent electro-catalytical property. Au NPs functionalized porous graphene oxide (p-GO@Au) were used as sensing platforms and primary antibodies carriers, which can accelerate the electron transfer and improve the load capacity of primary antibodies (Ab1), improving the sensitivity of the immunosensor...
November 9, 2017: Biosensors & Bioelectronics
Nan Li, Aung Than, Jie Chen, Fengna Xi, Jiyang Liu, Peng Chen
Hydrogen sulfide (H2S), being an important gaseous signaling molecule, has been gaining increasing attention for its involvement in a wide range of physiological processes. Herein, we developed a novel fluorescence turn-on nanoprobe for selective and sensitive detection of H2S based on graphene quantum dots (GQDs) conjugated with (2,4-dinitrophenoxy)tyrosine (DNPTYR). Taking advantage of its high fluorescence quantum yield, biocompatibility, photostability, and ease to be uptaken by cells, the GQD-based fluorescence probe was further employed for real-time monitoring of the triggered dynamic change of the intracellular H2S level in live cells...
November 14, 2017: Biomaterials Science
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