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Graphene biocompatibility

Xiaoyi Zhang, Ling Wang, Qiang Lu, David L Kaplan
Mass production of high quality graphene dispersions under mild conditions impacts the utility of the material for biomedical applications. Various proteins have been used to prepare graphene dispersions, rare sources and expensive prices for these proteins restrict their large scale utility for the production of graphene. Here, inexpensive silk proteins as an abundant resource in nature were used for graphene exfoliation. The silk proteins were assembled into hydrophobic nanofibers with negative charge, and then optimized for the production of graphene...
June 18, 2018: ACS Applied Materials & Interfaces
Jinlei Miao, Haihui Liu, Yongbing Li, Xingxiang Zhang
Electronic waste (E-waste) contain large environmental contaminants such as toxic heavy metals and hazardous chemicals. These contaminants would migrate into drinking water or food chains and pose a serious threat to environment and human health. Biodegradable green electronics has great potential to address the issue of E-waste. Here we report on a novel biodegradable and flexible transparent electrode, integrate three-dimensionally (3D) interconnected conductive nanocomposites into edible starch-chitosan based substrates...
June 15, 2018: ACS Applied Materials & Interfaces
Mimi Lin, Suyan Shan, Peipei Liu, Liwei Ma, Libin Huang, Mei Yang, Tom Lawson, Zhifeng Wang, Zhenguo Huang, Bingyang Shi, Lu Yan, Yong Liu
An efficient and targeted treatment for tumor cells is demonstrated. This targeting is based upon the strong affinity between hydroxyl-functional groups on graphene and acidic tumors. The hydroxylated graphene (GOH) with a unique 2D architecture further improve the targeting capacity of the system via an enhanced permeability and retention (EPR) process. Polyethylene glycol (PEG) was employed for better biocompatibility and the antitumor drug doxorubicin (DOX) was then incorporated. These additions created a biocompatible system with a superior pH-dependent drug release property...
August 1, 2018: Journal of Biomedical Nanotechnology
Jelena Simonovic, Bosko Toljic, Nadja Nikolic, Jasna Vujin, Radmila Panajotovic, Rados Gajic, Elena Bekyarova, Amelia Cataldi, Vladimir Parpura, Jelena Milasin
Stem cell-based therapies are considered a promising treatment modality for many medical conditions. Several types of stem cells with variable differentiation potentials have been isolated from dental tissues, among them stem cells from apical papilla (SCAP). In parallel, new classes of biocompatible nanomaterials have also been developed, including graphene and carbon nanotube-based materials. The aim of the study was to assess whether graphene dispersion (GD) and water-soluble single walled carbon nanotubes (ws-SWCNT), may enhance SCAPs capacity to undergo neural differentiation...
June 12, 2018: Journal of Biomedical Materials Research. Part A
G Manasa, Ronald J Mascarenhas, Ashis K Satpati, Basavanakote M Basavaraja, Sriram Kumar
Due to the enforcement of regulatory restrictions to prevent risk to human health from Bisphenol A (BPA), its structural analogue Bisphenol F (BPF) has been introduced into the market as an alternative. But however recent studies describe BPF as an effectual endocrine disruptor. Hence, there is an indispensible need for research concerning BPF human and environmental exposure level. In this work, we have elicited the development of an economical electrochemical sensor, to quantify and investigate in detail the electrochemical behavior of BPF using carbon paste electrode (CPE) modified with zinc oxide reduced graphene nanocomposite (ZnO/G) and cetyltrimethylammonium bromide (CTAB)...
June 4, 2018: Colloids and Surfaces. B, Biointerfaces
S Chakraborty, T Ponrasu, S Chandel, M Dixit, V Muthuvijayan
Tissue engineering combines cells, scaffolds and signalling molecules to synthesize tissues in vitro . However, the lack of a functioning vascular network severely limits the effective size of a tissue-engineered construct. In this work, we have assessed the potential of reduced graphene oxide (rGO), a non-protein pro-angiogenic moiety, for enhancing angiogenesis in tissue engineering applications. Polyvinyl alcohol/carboxymethyl cellulose (PVA/CMC) scaffolds loaded with different concentrations of rGO nanoparticles were synthesized via lyophilization...
May 2018: Royal Society Open Science
Chaoxiu Ren, Xiangang Hu, Qixing Zhou
Both oxidative stress and neurotoxicity are huge challenges to human health, and effective methods and agents for resisting these adverse effects are limited, especially in vivo. It is shown here that, compared to large graphene oxide (GO) nanosheets, GO quantum dots (GOQDs), as nanozymes, efficiently reduce reactive oxygen species (ROS) and H2 O2 in 1-methyl-4-phenyl-pyridinium ion (MPP+ )-induced PC12 cells. In addition, GOQDs exert neuroprotective effects in a neuronal cell model by decreasing apoptosis and α-synuclein...
May 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Rethinam Senthil, Robert Berly, Thimmiah Bhargavi Ram, Nallathambi Gobi
PURPOSE: In this study, a blend of synthetic polymer (poly(vinyl) alcohol), natural polymer (collagen type I from fish bone), and graphene oxide nanoparticles is used to fabricate a composite nanofibrous scaffold, by electrospinning, for their potential application in accelerated wound healing. METHODS: The scaffold was characterized for its physicochemical and mechanical properties. In vitro studies were carried out using human keratinocyte cell line (HaCaT) which proved the biocompatibility of the scaffold...
May 1, 2018: International Journal of Artificial Organs
Pei-Xin Lai, Ju-Yi Mao, Binesh Unnikrishnan, Han-Wei Chu, Chien-Wei Wu, Huan-Tsung Chang, Chih-Ching Huang
Graphene oxide (GO) has unique structural properties, can effectively adsorb single-strand DNA through π-π stacking, hydrogen bonding and hydrophobic interactions, and is useful in many biotechnology applications. In this study, we developed a thrombin-binding-aptamers (15- and 29-mer) conjugated graphene oxide (TBA15/TBA29-GO) composite for the efficient inhibition of thrombin activity towards the formation of fibrin from fibrinogen. The TBA15/TBA29-GO composite was simply obtained by the self-assembly of TBA15/TBA29 hybrids on GO...
May 29, 2018: Biomaterials Science
Li Chen, Xin Duan, Zhou Xiang
Objective: To review the recent advances in the application of graphene oxide (GO) for bone tissue engineering. Methods: The latest literature at home and abroad on the GO used in the bone regeneration and repair was reviewed, including general properties of GO, degradation performance, biocompatibility, and application in bone tissue engineering. Results: GO has an abundance of oxygen-containing functionalities, high surface area, and good biocompatibility...
May 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Kai Wang, Qinyan Ma, Kai Pang, Beibei Ding, Jianming Zhang, Yongxin Duan
Novel hybrid nanomaterials composed of graphene and chitin nanofibers (ChNFs) were successfully prepared by one-pot ball milling. Under strong shear and collision force of ball milling, graphite was exfoliated to mono-layer or few-layer graphene with the assistance of chitin nanofibers. Unexpectedly, the hybridization of exfoliated graphene and ChNFs was realized simultaneously. Morphology analysis observed that the ChNFs were adsorbed tightly on the surface of graphene, providing for reduced graphene hydrophobicity and enhanced stability of the hybrid dispersion...
August 15, 2018: Carbohydrate Polymers
Elham Einafshar, Ali Haghighi Asl, Azadeh Hashem Nia, Marzieh Mohammadi, Azim Malekzadeh, Mohammad Ramezani
SN38 is an active metabolite of irinotecan, which was approved for clinical use in metastatic colorectal cancers. However, poor aqueous solubility and inactivation at pH below 6 are the main limitations of its use. In the current study, we separately conjugated α-, β- and γ-cyclodextrins to graphene oxide sheets to produce stable, biocompatible nanocarriers for SN38 delivery. The conjugates were coordinated with Fe3 O4 in the form of superparamagnetic iron oxide nanoparticles. Then, SN38 was non-covalently conjugated to the developed nano-conjugate in order to overcome its solubility and stability problems and reduce its side effects...
August 15, 2018: Carbohydrate Polymers
Yahong Zhao, Changmei Niu, Jiahuan Gong, Hongbo Wang, Yumin Yang
Objective: To explore the construction and biocompatibility in vitro evaluation of the electrospun-graphene (Gr)/silk fibroin (SF) nanofilms. Methods: The electrostatic spinning solution was prepared by dissolving SF and different mass ratio (0, 5%, 10%, 15%, and 20%) of Gr in formic acid solution. The hydrophilia and hydrophobic was analyzed by testing the static contact angle of electrostatic spinning solution of different mass ratio of Gr. Gr-SF nanofilms with different mass ratio (0, 5%, 10%, 15%, and 20%, as groups A, B, C, D, and E, respectively) were constructed by electrospinning technology...
September 1, 2017: Chinese Journal of Reparative and Reconstructive Surgery
Tengfei Liu, Yuqing Liu, Menglong Liu, Ying Wang, Weifeng He, Gaoqiang Shi, Xiaohong Hu, Rixing Zhan, Gaoxing Luo, Malcolm Xing, Jun Wu
Background: Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to irrational application of antibiotics increases treatment cost and mortality. Graphene oxide (GO) has been generally reported to possess high antimicrobial activity against a wide range of bacteria in vitro . In this study, a graphene oxide-quaternary ammonium salt (GO-QAS) nanocomposite was synthesized and thoroughly investigated for synergistic antibacterial activity, underlying antibacterial mechanisms and biocompatibility in vitro and in vivo ...
2018: Burns and trauma
Yuanling Sun, Chaofan Ding, Yanna Lin, Weiyan Sun, Hao Liu, Xiaodong Zhu, Yuxue Dai, Chuannan Luo
In this work, a highly selective and sensitive chemiluminescence (CL) biosensor was prepared for adenosine (AD) detection based on carbon quantum dots (CQDs) catalyzing the CL system of luminol-H2 O2 under alkaline environment and CQDs was released from the surface of AD aptamers functionalized graphene @ magnetic β-cyclodextrin polymers (GO@Fe3 O4 @β-CD@A-Apt). Firstly, GO@Fe3 O4 @β-CD and CQDs were prepared and characterized by transmission electron microscopy (TEM), scanning electron microscope (SEM), UV-Vis absorption spectra (UV), fluorescence spectra (FL), fourier transform infrared (FTIR) and X-ray powder diffraction (XRD)...
August 15, 2018: Talanta
Riccardo Guazzo, Chiara Gardin, Gloria Bellin, Luca Sbricoli, Letizia Ferroni, Francesco Saverio Ludovichetti, Adriano Piattelli, Iulian Antoniac, Eriberto Bressan, Barbara Zavan
The world of dentistry is approaching graphene-based nanomaterials as substitutes for tissue engineering. Apart from its exceptional mechanical strength, electrical conductivity and thermal stability, graphene and its derivatives can be functionalized with several bioactive molecules. They can also be incorporated into different scaffolds used in regenerative dentistry, generating nanocomposites with improved characteristics. This review presents the state of the art of graphene-based nanomaterial applications in the dental field...
May 20, 2018: Nanomaterials
Byeongho Park, Heehong Yang, Tai Hwan Ha, Hyun Seo Park, Seung Ja Oh, Yong-Sang Ryu, Youngho Cho, Hyo-Suk Kim, Juyeong Oh, Dong Kyu Lee, Chulki Kim, Taikjin Lee, Minah Seo, Jaebin Choi, Young Min Jhon, Deok Ha Woo, Seok Lee, Seok Hwan Kim, Hyuk-Jae Lee, Seong Chan Jun, Hyun Seok Song, Tai Hyun Park, Jae Hun Kim
Photosensitive materials contain biologically engineered elements and are constructed using delicate techniques, with special attention devoted to efficiency, stability, and biocompatibility. However, to date, no photosensitive material has been developed to replace damaged visual-systems to detect light and transmit the signal to a neuron in the human body. In the current study, artificial nanovesicle-based photosensitive materials are observed to possess the characteristics of photoreceptors similar to the human eye...
May 18, 2018: Advanced Materials
Mengli Zhao, Ye Cao, Huanhuan Gong, Yanqiu Sun, Jianhua Deng, Dejun Li, Rongxin Wan, Hanqing Gu
One of the key challenges in engineering tissues for cell-based therapies is developing biocompatible scaffold materials to direct cell behavior. In this paper, the cytocompatibilities of a flexible three-dimensional graphene scaffold (3D-G) and the same scaffold implanted with nitrogen ions (N+ /3D-G) are compared using an in vitro assay based on 3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The N+ /3D-G samples were prepared from low-temperature hydrothermally synthesized flexible 3D-G by ion implantation and were found to display improved adhesion and proliferation of rat osteoblast and mouse fibroblast cells...
May 16, 2018: Biointerphases
Rongtao Zhao, Wen Kong, Mingxuan Sun, Yi Yang, Wanying Liu, Min Lv, Shiping Song, Lihua Wang, Hongbin Song, Rongzhang Hao
Various silver nanoparticle (AgNP)-decorated graphene oxide (GO) nanocomposites (GO-Ag) have received increasing attention owing to their antimicrobial activity and biocompatibility; however, their aggregation in physiological solutions and the generally complex synthesis methods warrant improvement. This study aimed to synthesize a polyethyleneimine (PEI)-modified and AgNP-decorated GO nanocomposite (GO-PEI-Ag) through a facile approach through microwave irradiation without any extra reductants and surfactants; its antimicrobial activity was investigated on Gram-negative/-positive bacteria (including drug-resistant bacteria) and fungi...
May 16, 2018: ACS Applied Materials & Interfaces
Yuping Liang, Congcong Xu, Guofeng Li, Tianchi Liu, Jun F Liang, Xing Wang
Kaolin is an effective and safe hemostatic agent for hemostasis. However, its ontic powder is difficult to use in actual practice. To develop a wieldy and powerful hemostat, composite strategy is usually a good choice. Herein, we developed a graphene-kaolin composite sponge (GKCS), synthesized with graphene oxide sheets, linker molecules and kaolin powders through a facile hydrothermal reaction. SEM observations support that GKCS has a porous structure, and EDS mapping further confirms that kaolin powders are embedded in graphene sheets...
May 8, 2018: Colloids and Surfaces. B, Biointerfaces
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