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Graphene biocompatibility

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https://www.readbyqxmd.com/read/28107626/polymeric-nanofibers-with-ultrahigh-piezoelectricity-via-self-orientation-of-nanocrystals
#1
Xia Liu, Jing Ma, Xiaoming Wu, Liwei Lin, Xiaohong Wang
Piezoelectricity in macromolecule polymers has been gaining immense attention, particularly for applications in biocompatible, implantable, and flexible electronic devices. This paper introduces core-shell-structured piezoelectric polyvinylidene fluoride (PVDF) nanofibers chemically wrapped by graphene oxide (GO) lamellae (PVDF/GO nanofibers), in which the polar β-phase nanocrystals are formed and uniaxially self-oriented by the synergistic effect of mechanical stretching, high-voltage alignment, and chemical interactions...
January 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28099026/unimer-assisted-exfoliation-for-high-concentrated-aqueous-dispersion-solutions-of-single-and-few-layered-van-der-waals-materials
#2
Changbong Yeon, Inyeal Lee, Gil-Ho Kim, Sun Jin Yun
We suggest unimer-assisted exfoliation method for the exfoliation of Van der Waals two-dimensional (2D) materials such as graphene, MoS2, and h-BN, and show that the micellar size is a critical parameter for enhancing the exfoliation efficiency. To explain the effectiveness of the unimers on the exfoliation, the influence of micellar size of a biocompatible block copolymer, Pluronic F-68, is evaluated in view of the yield and thickness of exfoliated 2D flakes. By the addition of water-soluble alcohols, the surfactants exist in the form of unimer, which facilitates the intercalation into the layered materials and their exfoliation...
January 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28092742/short-term-in-vivo-exposure-to-graphene-oxide-can-cause-damage-to-the-gut-and-testis
#3
Marta Dziewięcka, Julia Karpeta-Kaczmarek, Maria Augustyniak, Magdalena Rost-Roszkowska
Graphene oxide (GO) has unique physicochemical properties and also has a potentially widespread use in every field of daily life (industry, science, medicine). Demand for nanotechnology is growing every year, and therefore many aspects of its toxicity and biocompatibility still require further clarification. This research assesses the in vivo toxicity of pure and manganese ion-contaminated GO that were administrated to Acheta domesticus with food (at 200mgkg(-1) of food) throughout their ten-day adult life...
January 9, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28090771/differential-adhesive-bioactive-properties-of-polymeric-surface-coated-with-graphene-oxide-thin-film
#4
Sudhin Thampi, A Maya Nandkumar, Vignesh Muthuvijayan, Ramesh Parameswaran
Surface engineering of implantable devices involving polymeric biomaterials has become an essential aspect for medical implants. Surface enhancement technique can provide an array of unique surface properties that improves its biocompatibility and functionality as an implant. Polyurethane based implants that have found extensively acclaimed usage as an implant in biomedical applications, especially in the area of cardiovascular devices still lacks any mechanism to ward off bacterial or platelet adhesion. To bring out such a defense mechanism we are proposing a surface modification technique...
January 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28069231/fabrication-of-redox-and-ph-dual-responsive-magnetic-graphene-oxide-microcapsules-via-sonochemical-method
#5
Linlin Dong, Chao Shi, Lanlan Guo, Ting Yang, Yuexin Sun, Xuejun Cui
In this study, the biocompatible redox and pH dual-responsive magnetic graphene oxide microcapsules (MGOMCs) were prepared by a simple sonochemical method. The disulfide bonds cross-linked the wall of MGOMCs were formed from the hydrosulfuryl on the surface of thiolated graphene oxide, which was synthesized by functionalizing graphene oxide with cysteine, showed an excellent redox-responsive property to control drugs release. Moreover, oleic acid modified Fe3O4 nanoparticles were encapsulated into the microcapsules successfully with the hydrophobic drugs dispersed in the hydroxy silicone oil...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28069192/acoustic-cavitation-induced-generation-of-stabilizer-free-extremely-stable-reduced-graphene-oxide-nanodispersion-for-efficient-delivery-of-paclitaxel-in-cancer-cells
#6
Renu Geetha Bai, Kasturi Muthoosamy, Fiona Natalia Shipton, Sivakumar Manickam
Graphene is one of the highly explored nanomaterials due to its unique and extraordinary properties. In this study, by utilizing a hydrothermal reduction method, graphene oxide (GO) was successfully converted to reduced graphene oxide (RGO) without using any toxic reducing agents. Following this, with the use of ultrasonic cavitation, profoundly stable few layer thick RGO nanodispersion was generated without employing any stabilizers or surfactants. During ultrasonication, shockwaves from the collapse of bubbles cause a higher dispersing energy to the graphene nanosheets which surpass the forces of Van der Waal's and π-π stacking and thus pave the way to form a stable aqueous nanodispersion of graphene...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28064129/a-novel-sandwich-type-electrochemical-immunosensor-for-psa-detection-based-on-ptcu-bimetallic-hybrid-2d-2d-rgo-g-c3n4
#7
Jinhui Feng, Yueyun Li, Mingdang Li, Faying Li, Jian Han, Yunhui Dong, Zhiwei Chen, Ping Wang, Hui Liu, Qin Wei
In this work, a sensitive sandwich-type electrochemical immunosensor was designed for the quantitative detection of prostate-specific antigen (PSA) by amperometric i-t. The Au loaded on thionine functionalized graphene oxide (Au@Th/GO) was used as a platform to immobilize primary antibodies (Ab1) and accelerate the electron transfer on the electrode interface. PtCu bimetallic hybrid were loaded on 2D/2D reduced graphene oxide/graphitic carbon nitride (PtCu@rGO/g-C3N4) with large surface area and biocompatibility, which were employed as labels for combining secondary antibodies (Ab2) and amplifying signals to improve the sensitivity of the designed immunosensor which attributes to its good activity for the reduction of hydrogen peroxide (H2O2)...
December 31, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28057464/graphene-quantum-dots-for-cancer-targeted-drug-delivery
#8
Daniela Iannazzo, Alessandro Pistone, Marina Salamò, Signorino Galvagno, Roberto Romeo, Salvatore V Giofré, Caterina Branca, Giuseppa Visalli, Angela Di Pietro
A biocompatible and cell traceable drug delivery system Graphene Quantum Dots (GQD) based, for the targeted delivery of the DNA intercalating drug doxorubicin (DOX) to cancer cells, is here reported. Highly dispersible and water soluble GQD, synthesized by acidic oxidation and exfoliation of multi-walled carbon nanotubes (MWCNT), were covalently linked to the tumor targeting module biotin (BTN), able to efficiently recognize biotin receptors over-expressed on cancer cells and loaded with DOX. Biological test performed on A549 cells reported a very low toxicity of the synthesized carrier (GQD and GQD-BTN)...
January 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28054508/electrochemical-platform-based-on-nitrogen-doped-graphene-chitosan-nanocomposite-for-selective-pb2-detection
#9
Lidia Magerusan, Crina Socaci, Maria Coros, Florina Pogacean, Marcela Rosu, Stefan Gergely, Stela Pruneanu, Cristian Leostean, Ioan Pana
A novel nanocomposite was developed and used for trace determination of Pb2+ cations from aqueous solutions. The nanocomposite was obtained by the association of N-doped graphene (N-Gr) with a biocompatible polymer, namely chitosan (Ch). The characterization of the new nanocomposite material (Ch-N-Gr) was performed using TEM, STEM-EDX, SEM, XRD and XPS techniques. Compared with the bare gold electrode (GE) a remarkable enhancement of the voltammetric response of the modified electrode (Ch-N-Gr/GE) was always observed...
January 5, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28054094/antibacterial-mechanisms-of-graphene-based-composite-nanomaterials
#10
REVIEW
Mauricio D Rojas-Andrade, Gustavo Chata, Dara Rouholiman, Junli Liu, Chad Saltikov, Shaowei Chen
Pathogenic bacteria are gaining resistance to conventional antibiotics at an alarming rate due to overuse and rapid transfer of resistance genes between bacterial populations. As bacterial resistance to antibiotics causes millions of fatalities worldwide, it is of urgent importance to develop a new class of antibiotic materials with both broad-spectrum bactericidal activity and suitable biocompatibility. Graphene derivatives are rapidly emerging as an extremely promising class of antimicrobial materials due to their diverse bactericidal mechanisms and relatively low cytotoxicity towards mammalian cells...
January 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28042941/ph-responsive-self-sacrificial-nanotheranostic-agent-for-potential-in-vivo-and-in-vitro-dual-modal-mri-ct-imaging-real-time-and-in-situ-monitoring-of-cancer-therapy
#11
Ludan Yue, Jinlong Wang, Zhichao Dai, Zunfu Hu, Xue Chen, Yafei Qi, Xiuwen Zheng, Dexin Yu
Multifunctional nanotheranostic agents have been highly commended due to the application to image-guided cancer therapy. Herein, based on the chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) and graphene oxide (GO), we develop a pH-responsive FePt-based multifunctional theranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging and in situ cancer inhibition. The fcc-FePt will release highly active Fe ions due to the low pH in tumor cells, which would catalyze H2O2 decomposition into reactive oxygen species (ROS) within the cells and further induce cancer cell apoptosis...
January 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28038737/biocompatible-electrospinning-chitosan-nanofibers-a-novel-delivery-system-with-superior-local-cancer-therapy
#12
Roya Sedghi, Alireza Shaabani, Zohreh Mohammadi, Fatemeh Yazdi Samadi, Elham Isaei
In this study, an electrospinning technique was used for the fabrication of novel biomedicated nanofibers which are applied for preventing wound infections and local chemotherapy. CURs containing nanofibers with a crosslinking agent (Si-O-Si network) have been produced through functionalization of graphene oxide with APTES. In vitro drug release profile results showed the novel nanofibers could limit the drug's initial burst release and provide better sustainability in comparison with the blend nanofibers without modified GO...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28026926/3d-printing-biocompatible-polyurethane-poly-lactic-acid-graphene-oxide-nanocomposites-anisotropic-properties
#13
Qiyi Chen, Joey Dacula Mangadlao, Jaqueline Wallat, Al De Leon, Jonathan K Pokorski, Rigoberto C Advincula
Blending thermoplastic polyurethane (TPU) with poly(lactic acid) (PLA) is a proven method to achieve a much more mechanically robust material, whereas the addition of graphene oxide (GO) is increasingly applied in polymer nanocomposites to tailor further their properties. On the other hand, additive manufacturing has high flexibility of structure design which can significantly expand the application of materials in many fields. This study demonstrates the fused deposition modeling (FDM) 3D printing of TPU/PLA/GO nanocomposites and its potential application as biocompatible materials...
January 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28026186/the-use-of-graphene-and-its-derivatives-for-liquid-phase-transmission-electron-microscopy-of-radiation-sensitive-specimens
#14
Hoduk Cho, Matthew R Jones, Son C Nguyen, Matthew R Hauwiller, Alex Zettl, A Paul Alivisatos
One of the key challenges facing liquid-phase transmission electron microscopy (TEM) of biological specimens has been the damaging effects of electron beam irradiation. The strongly ionizing electron beam is known to induce radiolysis of surrounding water molecules, leading to the formation of reactive radical species. In this study, we employ DNA-assembled Au nanoparticle superlattices (DNA-AuNP superlattices) as a model system to demonstrate that graphene and its derivatives can be used to mitigate electron beam-induced damage...
December 28, 2016: Nano Letters
https://www.readbyqxmd.com/read/28025640/the-potential-role-of-graphene-in-developing-the-next-generation-of-endomaterials
#15
REVIEW
Nikolaos Patelis, Demetrios Moris, Sean Matheiken, Chris Klonaris
Graphene is the first 2-dimensional material and possesses a plethora of original properties. Graphene and its derivatives have exhibited a great potential in a number of fields, both medical and nonmedical. The aim of this review is to set the theoretical basis for further research in developing graphene-based endovascular materials. An extensive search was performed in medical and bioengineering literature. Published data on other carbon materials, as well as limited data from medical use of graphene, are promising...
2016: BioMed Research International
https://www.readbyqxmd.com/read/28025564/versatile-flexible-graphene-multielectrode-arrays
#16
Dmitry Kireev, Silke Seyock, Mathis Ernst, Vanessa Maybeck, Bernhard Wolfrum, Andreas Offenhäusser
Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells...
December 23, 2016: Biosensors
https://www.readbyqxmd.com/read/28024361/monitoring-dynamic-cellular-redox-homeostasis-using-fluorescence-switchable-graphene-quantum-dots
#17
Nan Li, Aung Than, Chencheng Sun, Jingqi Tian, Jie Chen, Kanyi Pu, Xiaochen Dong, Peng Chen
Monitoring cellular redox homeostasis is critical to the understanding of many physiological functions ranging from immune reactions to metabolism, as well as to the understanding of pathological development ranging from tumorigenesis to aging. Nevertheless, there is currently a lack of appropriate probes for this ambition, which should be reversibly, sensitively, and promptly responsive to a wide range of physiological oxidants and reductants. In this work, a redox-sensitive fluorescence-switchable probe is designed based on graphene quantum dots (GQDs) functionalized with a chelated redox Fe(2+)/Fe(3+) couple...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28012318/graphene-interfaced-electrical-biosensor-for-label-free-and-sensitive-detection-of-foodborne-pathogenic-e-coli-o157-h7
#18
Ashish Pandey, Yasar Gurbuz, Volkan Ozguz, Javed H Niazi, Anjum Qureshi
E. coli O157:H7 is an enterohemorrhagic bacteria responsible for serious foodborne outbreaks that causes diarrhoea, fever and vomiting in humans. Recent foodborne E. coli outbreaks has left a serious concern to public health. Therefore, there is an increasing demand for a simple, rapid and sensitive method for pathogen detection in contaminated foods. In this study, we developed a label-free electrical biosensor interfaced with graphene for sensitive detection of pathogenic bacteria. This biosensor was fabricated by interfacing graphene with interdigitated microelectrodes of capacitors that were biofunctionalized with E...
December 16, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28009506/earthicle-the-design-of-a-conceptually-new-type-of-particle
#19
Vuk Uskoković, Sebastian Pernal, Victoria M Wu
The conception and the steps made in the design of a conceptually new type of composite particle, so-called "earthicle", are being described. This particle is meant to roughly mimic the layered structure of the Earth, having zerovalent iron core, silicate mantle, and a thin carbonaceous crust resembling the biosphere and its geological remnants. Particles are made in a stable colloidal form in an aqueous medium, involving chemical precipitation and pyrolysis of citric acid in the solution. The effects of various synthesis parameters were studied, including borohydride and oleate concentrations, APTES/TEOS molar ratio, chemical nature of the carbon precursors, and others...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28004583/mesoporous-silica-coated-polydopamine-functionalized-reduced-graphene-oxide-for-synergistic-targeted-chemo-photothermal-therapy
#20
Leihou Shao, Ruirui Zhang, Jianqing Lu, Caiyan Zhao, Xiongwei Deng, Yan Wu
The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal effect...
January 18, 2017: ACS Applied Materials & Interfaces
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