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https://www.readbyqxmd.com/read/27916753/-diagnosis-of-idiopathic-inflammatory-myopathy-a-muscle-pathology-perspective
#1
Michio Inoue, Ichizo Nishino
Idiopathic inflammatory myopathies are historically classified into polymyositis and dermatomyositis based on the presence or absence of skin lesions. Recently, however, a more histology-oriented classification into 6 subtypes has been proposed. The subtypes include dermatomyositis, polymyositis, inclusion body myositis, immune-mediated necrotizing myopathy, anti-synthetase syndrome, and non-specific myositis. With strict criteria applied, polymyositis is now extremely rare, while immune-mediated necrotizing myopathy is the most common among all inflammatory myopathies and is often associated with autoantibodies including those for signal recognition particle (SRP) or 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)...
December 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27909085/a-negative-antinuclear-antibody-does-not-indicate-autoantibody-negativity-in-myositis-role-of-anticytoplasmic-antibody-as-a-screening-test-for-antisynthetase-syndrome
#2
Rohit Aggarwal, Namrata Dhillon, Noreen Fertig, Diane Koontz, Zengbiao Qi, Chester V Oddis
OBJECTIVE: To evaluate the utility of anticytoplasmic autoantibody (anti-CytAb) in antisynthetase antibody-positive (anti-SynAb+) patients. METHODS: Anti-SynAb+ patients were evaluated for antinuclear antibody (ANA) and anti-CytAb [cytoplasmic staining on indirect immunofluorescence (IIF)] positivity. Anti-SynAb+ patients included those possessing anti-Jo1 and other antisynthetase autoantibodies. Control groups included scleroderma, systemic lupus erythematosus, Sjögren syndrome, rheumatoid arthritis, and healthy subjects...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27858337/development-and-evaluation-of-a-standardized-elisa-for-the-determination-of-autoantibodies-against-cn-1a-mup44-nt5c1a-in-sporadic-inclusion-body-myositis
#3
Sabine L Kramp, Dmitry Karayev, Guo Shen, Allan L Metzger, Robert I Morris, Eugene Karayev, Yvonne Lam, Richard M Kazdan, Ger J M Pruijn, Sandra Saschenbrecker, Cornelia Dähnrich, Wolfgang Schlumberger
PURPOSE: Sporadic inclusion body myositis (sIBM) is an autoimmune degenerative disease of the muscle, with inflammatory infiltrates and inclusion vacuoles. Its pathogenesis is not fully understood and the diagnosis is hampered by its imprecise characteristics, at times indistinguishable from other idiopathic inflammatory myopathies such as polymyositis and dermatomyositis. The diagnosis may be assisted by the detection of autoantibodies targeting Mup44, a skeletal muscle antigen identified as cytosolic 5'-nucleotidase 1A (cN-1A, NT5C1A)...
December 2016: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27635025/a-systematic-approach-for-developing-bacteria-specific-imaging-tracers
#4
Alvaro A Ordonez, Edward A Weinstein, Lauren E Bambarger, Vikram Saini, Yong S Chang, Vincent P DeMarco, Mariah H Klunk, Michael E Urbanowski, Kimberly L Moulton, Allison M Murawski, Supriya Pokkali, Alvin S Kalinda, Sanjay K Jain
: The modern patient is increasingly susceptible to bacterial infections including those due to multi-drug resistant organisms (MDROs). Noninvasive whole-body analysis with pathogen-specific imaging technologies can significantly improve patient outcomes by rapidly identifying a source of infection and monitoring the response to treatment, but no such technology exists clinically. METHODS: We systematic screened 961 random, radiolabeled molecules in silico as substrates for essential metabolic pathways in bacteria, followed by in vitro uptake in representative bacteria - Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and mycobacteria...
September 15, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27540445/acute-onset-anti-synthetase-syndrome-with-pericardial-effusion-and-non-specific-interstitial-pneumonia
#5
Aditya Shah, Samir R Patel
Anti-synthetase syndrome (AS) is a clinical entity which is described classically by the triad of interstitial lung disease (ILD), inflammatory myositis and presence of aminoacyl-tRNA synthetase antibodies (ASA). We describe a rare presentation of this condition with regard to the uncharacteristically acute nature of presentation, acute decompensation in clinical condition, development of acute interstitial pneumonitis requiring rescue extracorporeal membrane oxygenation (ECMO) and accompaniment of significant pericardial effusion on presentation, followed by rapid improvement with initiation of steroids...
September 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27494325/contribution-of-dot-blot-assay-to-the-diagnosis-and-management-of-myositis-a-three-year-practice-at-a-university-hospital-centre
#6
Clothilde Martel, Guillaume Vignaud, Eric Liozon, Laurent Magy, Gael Gallouedec, Kim Ly, Holly Bezanahary, Anne Cypierre, François-Xavier Lapébie, Sylvain Palat, Guillaume Gondran, Marie-Odile Jauberteau, Anne-Laure Fauchais
OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases with wide clinical spectrum that may lead to delayed diagnosis. The aim of this study was to examine the impact of IIM-specific dot-blot assay on diagnostic process of patients presenting with muscular or systemic symptoms evocating of IIM. METHODS: We collected all the prescriptions of an IIM specific dot-blot assay (8 autoantigens including Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, PM/Scl and Scl-70) over a 38-month period...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27477574/a-case-of-anti-nuclear-matrix-protein-2-antibody-positive-myopathy-associated-with-lung-cancer
#7
Shin Ohta, Ki-Ichi Unoda, Hideto Nakajima, Soichiro Ikeda, Yasuhito Hamaguchi, Fumiharu Kimura
Myositis-specific autoantibodies (MSAs) are associated with myositis. Anti-nuclear matrix protein 2 (NXP-2) antibody was recently identified as a major MSA and was observed mostly in juvenile dermatomyositis. We report the case of a 44-year-old man who presented with myopathy with anti-NXP-2 antibody and large cell carcinoma of the lung. He was hospitalized because of myalgia and edema of limbs. Neurological examination revealed mild proximal-dominant weakness in all four extremities, and laboratory studies showed elevated creatine kinase level (6,432 IU/l)...
August 31, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27477023/orthotic-management-of-instability-of-the-knee-related-to-neuromuscular-and-central-nervous-system-disorders-systematic-review-qualitative-study-survey-and-costing-analysis
#8
Joanne O'Connor, Dorothy McCaughan, Catriona McDaid, Alison Booth, Debra Fayter, Roccio Rodriguez-Lopez, Roy Bowers, Lisa Dyson, Cynthia P Iglesias, Simon Lalor, Rory J O'Connor, Margaret Phillips, Gita Ramdharry
BACKGROUND: Patients who have knee instability that is associated with neuromuscular disease (NMD) and central nervous system (CNS) conditions can be treated using orthoses, such as knee-ankle-foot orthoses (KAFOs). OBJECTIVES: To assess existing evidence on the effectiveness of orthoses; patient perspectives; types of orthotic devices prescribed in the UK NHS; and associated costs. METHODS: Qualitative study of views of orthoses users - a qualitative in-depth interview study was undertaken...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27424830/a-case-of-non-specific-interstitial-pneumonia-with-recurrent-gastric-carcinoma-and-anti-jo-1-antibody-positive-myositis
#9
Chikara Ebisutani, Isao Ito, Masanori Kitaichi, Naoya Tanabe, Michiaki Mishima, Seizo Kadowaki
We report the first case of non-specific interstitial pneumonia (NSIP) in a patient with cancer-associated myositis (CAM) that emerged along with the recurrence of the cancer. A 60-year-old woman, with a history of partial gastrectomy for gastric cancer 11 years ago, presented with exertional dyspnea with anti-Jo-1 antibody-positive myositis. Surgical lung biopsy showed NSIP with metastatic gastric cancer. Accordingly, her condition was diagnosed as CAM with cancer recurrence. In patients with a history of cancer, development of myositis may indicate cancer recurrence; therefore, careful observation would be necessary...
July 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27295700/autoantibodies-in-adult-patients-with-idiopathic-inflammatory-myopathies-in-buenos-aires
#10
Graciela N Gómez, María De Los Ángeles Gargiulo, Nicolás Pérez, María Victoria Collado, Lorena V Suárez, Marina Khoury, Judith F Sarano
The idiopathic inflammatory myopathies(IIM) are a heterogeneous group of diseases of the skeletal muscle. On the basis of clinical, serologic and histological differences, they are classified in dermatomyositis (DM), polymyositis (PM), inclusion body myositis and immunomediated necrotizing myopathy. Autoantibodies directed against nuclear and cytoplasmic antigens are present with variable frequencies among studies. Myositis-specific antibodies (MSAs) are useful in IIM because they contribute to the diagnosis, help to identify different clinical subsets, and have prognostic value...
2016: Medicina
https://www.readbyqxmd.com/read/27170605/bilateral-dacryoadenitis-as-initial-presentation-of-a-locally-aggressive-and-unresponsive-limited-form-of-orbital-granulomatosis-with-polyangiitis
#11
Rute Lopes Caçola, Sandra Alves Morais, Rui Carvalho, Rui Môço
Limited orbital granulomatosis with polyangiitis (GPA) is uncommon and its diagnosis may be delayed, especially when isolated lacrimal involvement is the initial presentation, because clinical manifestations are non-specific and systemic diagnostic criteria are not applicable. Making an early diagnosis despite the absence of systemic progression is extremely important because in some cases the disease is locally destructive, with irreversible visual and functional loss, and it can be refractory to corticosteroids and conventional immunosuppressive drugs to induce remission...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27162291/-autoimmune-diseases-with-the-presence-of-anti-ku-antibodies-analysis-of-three-cases
#12
Ewa Wielosz, Maria Majdan, Radosław Jeleniewicz, Marcin Mazurek
a-Ku are rare antibodies, which are reported in course of connective tissue diseases. Their prevalence ranges from 0 to 10% , 2%, on average. The main symptoms associated with the presence of a-Ku antibodies include: myositis, arthritis, Raynaud`s phenomenon and skin lesions. The above features are often defined as autoimmune clinical syndrome associated with a-Ku antibodies. In recent years, three cases with the presence of a-Ku antibodies were observed at the Department of Rheumatology and Connective Tissue Diseases...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27055157/prevalence-and-the-clinical-outcome-of-atrial-fibrillation-in-patients-with-autoimmune-rheumatic-disease
#13
Yong-Soo Baek, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Yun Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
BACKGROUND: Systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). However, little evidence exists whether the risk of AF is increased in autoimmune rheumatic disease (ARD). METHODS: In 20,772 consecutive ARD patients (mean age 42±17years, 13,683 female) in a tertiary hospital from 2005 to 2015, AF prevalence, comorbidities and cardiovascular (CV) outcomes were evaluated. RESULTS: AF was observed in 235 (1...
July 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26933302/antisynthetase-syndrome-an-under-recognized-cause-of-interstitial-lung-disease
#14
Venkata Nagarjuna Maturu, Arjun Lakshman, Amanjit Bal, Varun Dhir, Aman Sharma, Mandeep Garg, Biman Saikia, Ritesh Agarwal
BACKGROUND: Antisynthetase syndrome (AS) is an uncommon and under-recognised connective tissue disease characterized by the presence of antibodies to anti-aminoacyl t-RNA synthetase along with features of interstitial lung disease (ILD), myositis and arthritis. The aim of the current study is to describe our experience with management of AS. MATERIALS AND METHODS: This was a 2-year (2013-2014) retrospective analysis of patients diagnosed with anti-Jo-1-related AS...
January 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/26712399/-expression-of-retinoic-acid-i-nducible-gene-i-in-the-muscle-tissues-of-idiopathic-inflammatory-myopathies
#15
Jingwei Lü, Tingjun Dai, Ling Li, Wei Li, Kunqian Ji, Chuanzhu Yan
OBJECTIVE: To investigate the expression of retinoic acid-I inducible gene I (RIG-I) in the muscle tissues from patients with idiopathic inflammatory myopathies (IIMs), and to speculate the possible role of RIG-I in the immunopathogenesis of IIMs. METHODS: Muscle specimens were obtained from 20 dermatomyositis (DM) and 20 polymyositis (PM) patients who underwent muscle biopsies from February 2010 to April 2014 at Qilu hospital affiliated to Shandong University. Besides, 4 facioscapulohumeral muscular dystrophy (FSHD), and 4 non-myopathic patients were taken as control group...
June 16, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26604081/-rationale-for-a-diagnostic-approach-in-non-graves-orbital-inflammation-report-of-61%C3%A2-patients
#16
A Gavard-Perret, J Lagier, J Delmas, J Delas, J-P Adenis, P-Y Robert
INTRODUCTION: Orbital inflammatory syndromes include a wide variety of inflammatory intraorbital processes which are very different in terms of clinical presentation and prognosis. We currently prefer to differentiate so-called "specific" inflammations, for which an etiology is able to be identified, from idiopathic orbital inflammatory syndromes (IOIS), for which the etiology remains unknown and the histology is nonspecific. PURPOSE: To propose an efficient diagnostic approach for clinicians managing patients with non-Graves' orbital inflammations...
December 2015: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/26552061/bace-1-ps-1-and-sapp%C3%AE-levels-are-increased-in-plasma-from-sporadic-inclusion-body-myositis-patients-surrogate-biomarkers-among-inflammatory-myopathies
#17
M Catalán-García, G Garrabou, C Morén, M Guitart-Mampel, I Gonzalez-Casacuberta, A Hernando, Jm Gallego-Escuredo, D Yubero, F Villaroya, R Montero, A Selva O-Callaghan, F Cardellach, Jm Grau
Sporadic inclusion body myositis (sIBM) is a rare disease which is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degeneration represented by the accumulation of protein depots constituted by β-amyloid peptide, among others. We aim to perform a screening in plasma of circulating molecules related to the putative etiopathogenesis of sIBM to determine potential surrogate biomarkers for diagnosis. Plasma from 21 sIBM patients and 20 age and gender-paired healthy controls were collected and stored at -80ºC...
November 3, 2015: Molecular Medicine
https://www.readbyqxmd.com/read/26506673/interstitial-lung-disease-as-first-clinical-manifestation-within-the-antisynthetase-syndrome-dermatomyositis
#18
Daniel Trăilă, Ovidiu Fira Mlădinescu, Cristian Oancea, Voicu Tudorache
Diffuse interstitial pneumopathies within the diseases of the connective tissue are often a diagnosis challenge, sometimes being the initial or dominant manifestation of the underlying autoimmune disease. The case of a young man shall be presented with relatively quick dyspnoea which has appeared under the conditions of an efficient physical status and without any notable pathological history. The cause of the dyspnoea is found to be a interstitial lung disease with radiological and histopathological pattern of non-specific interstitial pneumonia...
2015: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/26502301/cardiac-abnormalities-in-adult-patients-with-polymyositis-or-dermatomyositis-as-assessed-by-noninvasive-modalities
#19
L P Diederichsen, J A Simonsen, A C Diederichsen, S Hvidsten, M Hougaard, P Junker, K Søndergaard, I E Lundberg, N Tvede, N C F Sandgaard, A F Christensen, L Dreyer, S Kay, K S Eskerud, H Petersen, L Ejstrup, S Jacobsen
OBJECTIVE: Cardiac events are a major cause of death in patients with idiopathic inflammatory myopathies. The study objective was in a controlled setting to describe cardiac abnormalities by noninvasive methods in a cohort of patients with polymyositis (PM) or dermatomyositis (DM) and to identify predictors for cardiac dysfunction. METHODS: In a cross-sectional study, 76 patients with PM/DM and 48 matched healthy controls (HCs) were assessed by serum levels of cardiac troponin I, electrocardiography, Holter monitoring, echocardiography with tissue Doppler imaging, and quantitative cardiac (99m) Tc-pyrophosphate ((99m) Tc-PYP) scintigraphy...
July 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26446265/interferon-regulated-chemokine-score-associated-with-improvement-in-disease-activity-in-refractory-myositis-patients-treated-with-rituximab
#20
RANDOMIZED CONTROLLED TRIAL
Consuelo M López De Padilla, Cynthia S Crowson, Molly S Hein, Michael A Strausbauch, Rohit Aggarwal, Marc C Levesque, Dana P Ascherman, Chester V Oddis, Ann M Reed
OBJECTIVES: The purpose of this study was to investigate whether serum interferon (IFN)-regulated chemokine and distinct cytokine response profiles are associated with clinical improvement in patients with refractory inflammatory myopathy treated with rituximab. METHODS: In a randomised, placebo-phase trial Rituximab in Myositis Trial (RIM), 200 refractory adult and paediatric myositis subjects received rituximab. Following rituximab, clinical response and disease activity were assessed...
September 2015: Clinical and Experimental Rheumatology
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