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https://www.readbyqxmd.com/read/28110272/mitonuclear-interactions-mediate-transcriptional-responses-to-hypoxia-in-drosophila
#1
Jim A Mossman, Jennifer G Tross, Nick A Jourjine, Nan Li, Zhijin Wu, David M Rand
Among the major challenges in quantitative genetics and personalized medicine is to understand how gene × gene interactions (G × G: epistasis) and gene × environment interactions (G × E) underlie phenotypic variation. Here, we use the intimate relationship between mitochondria and oxygen availability to dissect the roles of nuclear DNA (nDNA) variation, mitochondrial DNA (mtDNA) variation, hypoxia, and their interactions on gene expression in Drosophila melanogaster Mitochondria provide an important evolutionary and medical context for understanding G × G and G × E given their central role in integrating cellular signals...
November 14, 2016: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28109305/medical-pluralism-and-livestock-health-ethnomedical-and-biomedical-veterinary-knowledge-among-east-african-agropastoralists
#2
Mark A Caudell, Marsha B Quinlan, Robert J Quinlan, Douglas R Call
BACKGROUND: Human and animal health are deeply intertwined in livestock dependent areas. Livestock health contributes to food security and can influence human health through the transmission of zoonotic diseases. In low-income countries diagnosis and treatment of livestock diseases is often carried out by household members who draw upon both ethnoveterinary medicine (EVM) and contemporary veterinary biomedicine (VB). Expertise in these knowledge bases, along with their coexistence, informs treatment and thus ultimately impacts animal and human health...
January 21, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28109168/integrated-omics-analysis-of-specialized-metabolism-in-medicinal-plants
#3
Amit Rai, Kazuki Saito, Mami Yamazaki
Medicinal plants are the rich source of highly diverse specialized metabolites with important pharmacological properties. Until recently, plant biologists were limited in their approach to explore biosynthetic pathways of these metabolites, mainly due to the scarcity of plant genomics resources. Recent advancements in the high-throughput large-scale analytical methods have enabled plant biologists to discover biosynthetic pathways for important plant-based medicinal metabolites. Reduced cost to generate omics datasets, and the development of computational tools for their analysis and integration have led to the elucidation of biosynthetic pathways of several plant origin bio-active metabolites...
January 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28108960/dual-acting-biofunctionalised-scaffolds-for-applications-in-regenerative-medicine
#4
Camilo Chaves, Chuanyu Gao, Jerome Hunckler, Moustafa Elsawy, Josette Legagneux, Gilles Renault, Alain Charles Masquelet, Achala de Mel
Off the shelf scaffolds for replacing ultra-small diameter vascular grafts are valuable for reconstruction of diseased or damaged vessels. The limitations for such grafts include optimal handling with ready availability of varied lengths of grafts, graft patency with the ability to replace the function of active cellular mechanisms and adequate mechanical properties to maintain physicochemical function. We used a well-established, solvent casting method for potential tissue replacement scaffold fabrication with incorporated bioactive molecules, which we have previously explored to confer haemocompatibility...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28108416/symptoms-and-the-body-taking-the-inferential-leap
#5
REVIEW
Omer Van den Bergh, Michael Witthöft, Sibylle Petersen, Richard J Brown
The relationship between the conscious experience of physical symptoms and indicators of objective physiological dysfunction is highly variable and depends on characteristics of the person, the context and their interaction. This relationship often breaks down entirely in the case of "medically unexplained" or functional somatic symptoms, violating the basic assumption in medicine that physical symptoms have physiological causes. In this paper, we describe the prevailing theoretical approach to this problem and review the evidence pertaining to it...
January 17, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28108381/metabolomic-study-of-the-intervention-effects-of-shuihonghuazi-formula-a-traditional-chinese-medicinal-formulae-on-hepatocellular-carcinoma-hcc-rats-using-performance-hplc-esi-tof-ms
#6
Yongrui Bao, Shuai Wang, Xinxin Yang, Li Tianjiao, Mingyue Xia, Xiansheng Meng
ETHNOPHARMACOLOGICAL RELEVANCE: Metabolomics is the comprehensive assessment of endogenous metabolites of a biological system in a holistic context, and its property consists with the global view of Traditional Chinese Medicine (TCM). Shuihonghuazi Formula (SHHZF) has been used for liver cancer early treatment in clinical for more than thirty years, but its mechanism remains unclear completely. This paper was designed to explore the therapeutic effects of SHHZF on liver cancer and its metabolomic characters...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28107855/a-close-look-at-an-integrative-treatment-package-for-bell-s-palsy-in-korea
#7
Seung Min Kathy Lee, Suji Lee, Jun Hyeong Park, Jongbae J Park, Sanghoon Lee
OBJECTIVE: To provide an overview of the integrative treatment package for Bell's palsy provided at Kyung Hee University Korean Medicine Hospital (KHU KMH). SUMMARY: The Facial Palsy Center at KHU KMH has been providing integrative treatment for Bell's palsy patients during the past three decades. Within 72 h of symptom onset, corticosteroids are recommended but complementary treatment including acupuncture and herbal medicine can be used to help suppress inflammation and nerve degeneration...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28106829/advances-in-monitoring-cell-based-therapies-with-magnetic-resonance-imaging-future-perspectives
#8
REVIEW
Ethel J Ngen, Dmitri Artemov
Cell-based therapies are currently being developed for applications in both regenerative medicine and in oncology. Preclinical, translational, and clinical research on cell-based therapies will benefit tremendously from novel imaging approaches that enable the effective monitoring of the delivery, survival, migration, biodistribution, and integration of transplanted cells. Magnetic resonance imaging (MRI) offers several advantages over other imaging modalities for elucidating the fate of transplanted cells both preclinically and clinically...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106333/translating-precision
#9
EDITORIAL
Michael A Pacanowski
Precision medicine is based on a simple precept that deep information about an individual patient can be used to guide his or her health care. In the not-too-distant future, clinicians may have point-of-care access to an individual's entire genome, dense data captured from wearable devices, and informatics tools that aggregate data from clinical experience to allow for real-time decision support. The innovative technologies being developed in pursuit of precision medicine afford researchers and clinicians the opportunity to generate and consume information at an unprecedented scale...
January 20, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28105687/a-research-review-on-clinical-needs-technical-requirements-and-normativity-in-the-design-of-surgical-robots
#10
REVIEW
Carlos Eduardo Díaz, Roemi Fernández, Manuel Armada, Felipe García
Nowadays robots play an important role in society, mainly due to the significant benefits they provide when utilized for assisting human beings in the execution of dangerous or repetitive tasks. Medicine is one of the fields in which robots are gaining greater use and development, especially those employed in minimally invasive surgery (MIS). However, due to the particular conditions of the human body where robots have to act, the design of these systems is complex, not only from a technical point of view, but also because the clinical needs and the normativity aspects are important considerations that have to be taken into account in order to achieve better performances and more secure systems for patients and surgeons...
January 20, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28104618/hysa-a-hybrid-structural-variant-assembly-approach-using-next-generation-and-single-molecule-sequencing-technologies
#11
Xian Fan, Mark Chaisson, Luay Nakhleh, Ken Chen
Achieving complete, accurate and cost-effective assembly of human genomes is of great importance for realizing the promise of precision medicine. The abundance of repeats and genetic variations in human genomes and the limitations of existing sequencing technologies call for the development of novel assembly methods that can leverage the complementary strengths of multiple technologies. We propose a hybrid structural variant assembly (HySA) approach that integrates sequencing reads from next-generation sequencing and single-molecule sequencing technologies to accurately assemble and detect structural variations in human genomes...
January 19, 2017: Genome Research
https://www.readbyqxmd.com/read/28104546/dying-in-intensive-care-units-of-india-commentaries-on-policies-and-position-papers-on-palliative-and-end-of-life-care
#12
REVIEW
Jaydeep Sengupta, Suhita Chopra Chatterjee
PURPOSE: This study critically examines the available policy guidelines on integration of palliative and end-of-life care in Indian intensive care units to appraise their congruence with Indian reality. MATERIALS AND METHODS: Six position statements and guidelines issued by the Indian Society for Critical Care Medicine and the Indian Association of Palliative Care from 2005 till 2015 were examined. The present study reflects upon the recommendations suggested by these texts...
December 24, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/28104096/telemedicine-in-the-management-of-type-2-diabetes-mellitus
#13
Guixia Wang, Zhengyun Zhang, Yakun Feng, Lin Sun, Xianchao Xiao, Gang Wang, Yuan Gao, Huan Wang, Hong Zhang, Yufeng Deng, Chenglin Sun
OBJECTIVE: To explore a model of Internet-based integrated management of diabetes, we established a remote diabetes medical service platform (U-Healthcare) and evaluated its effectiveness and practicality. MATERIALS AND METHODS: In total, 212 patients with type 2 diabetes mellitus were randomly assigned to 2 groups. Data from the intervention group were automatically transmitted through a glucometer; furthermore, this group received information regarding medicines, diet, exercise and other management through U-Healthcare...
January 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28103986/-holistic-integrative-medicine-the-road-to-the-future-of-the-development-of-burn-medicine
#14
D M Fan
Holistic integrative medicine is the road to the future of the development of burn medicine. Not only burn medicine, but also human medicine gradually enters the era of holistic integrative medicine. Holistic integrative medicine is different from translational medicine, evidence-based medicine or precision medicine, which integrates the most advanced knowledge and theories in medicine fields with the most effective practices and experiences in clinical specialties to form a new medical system.
January 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28103985/-ding-ganren-and-the-shanghai-professional-college-of-chinese-medicine
#15
Y E Ding
Ding Ganren (1866-1926), a distinguished representative of the Menghe Medical School, created a new school of unifying the Cold pathogenic disease with Warm febrile disease by adopting a new therapeutic method of integrating the Six-channel and Defense-qi-nutrient-blood syndrome differentiation, and simultaneously applying the classical formula with seasonal formula for treating against the exogenous febrile disease, which was quite an innovative approach. Ding Ganren paid high attention to the advancement of the education of Chinese medicine and founded the first official medical school in 1916 called the "Shanghai Professional College of Chinese Medicine" ...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28103978/-cosmetological-thinking-and-methods-in-tcm-in-the-sui-tang-dynasty
#16
Y J Wu
In the heyday of Chinese feudal society, women's status in the society of the Sui-Tang period was improved in the Tang Dynasty.The demand for female to stay young and anti-aging had attracted lots of attention in the society, thus providing a favorable social environment for the formation and development of Chinese herbal cosmetology. The important representative medical works on traditional Chinese medicine (TCM) were published in the Sui and Tang Dynasties, such as Bei ji qian jin yao fang (Essential Recipes for Emergent Use Worth A Thousand Gold), Qian jin yi fang (Supplement to Recipes Worth A Thousand Gold), Wai tai mi yao (Arcane Essentials from the Imperial Library) etc...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28103931/developing-a-framework-to-guide-the-de-adoption-of-low-value-clinical-practices-in-acute-care-medicine-a-study-protocol
#17
Jeanna Parsons Leigh, Daniel J Niven, Jamie M Boyd, Henry T Stelfox
BACKGROUND: Healthcare systems have difficulty incorporating scientific evidence into clinical practice, especially when science suggests that existing clinical practices are of low-value (e.g. ineffective or harmful to patients). While a number of lists outlining low-value practices in acute care medicine currently exist, less is known about how best to initiate and sustain the removal of low-value clinical practices (i.e. de-adoption). This study will develop a comprehensive list of barriers and facilitators to the de-adoption of low-value clinical practices in acute care facilities to inform the development of a framework to guide the de-adoption process...
January 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28103764/multimodal-pediatric-pain-management-part-2
#18
Stefan J Friedrichsdorf
Dr Stefan Friedrichsdorf speaks to Commissioning Editor Jade Parker: Stefan Friedrichsdorf, MD, is medical director of the Department of Pain Medicine, Palliative Care and Integrative Medicine at Children's Hospitals and Clinics of Minnesota in Minneapolis/St Paul, MN, USA, home to one of the largest and most comprehensive programs of its kind in the country. The pain and palliative care program is devoted to control acute, chronic/complex and procedural pain for inpatients and outpatients in close collaboration with all pediatric subspecialties at Children's Minnesota...
January 20, 2017: Pain Management
https://www.readbyqxmd.com/read/28103721/evidence-based-medicine-ebm-for-undergraduate-medical-students-a-six-step-integrative-approach
#19
Hani Atwa, Adel Abdelaziz
BACKGROUND: Nowadays, there is an increasing interest in practicing evidence-based medicine (EBM) to provide valid and up-to-date information about health problems and procedures for solving these problems. However, studying EBM among other medical education disciplines remains unsatisfactory. AIM: To design and pilot a basic course on EBM for undergraduate medical students in order to raise the awareness of the Saudi medical education community about this discipline...
January 20, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28102483/integrating-patient-concerns-into-parkinson-s-disease-management
#20
REVIEW
Shen-Yang Lim, Ai Huey Tan, Susan H Fox, Andrew H Evans, Soon Chai Low
Parkinson's disease (PD) is a complex motor and non-motor disorder and management is often challenging. In this review, we explore emerging approaches to improve the care of patients, drawing from the literature regarding patient-centred care, patient and caregiver perspectives and priorities, gaps in knowledge among patients and caregivers and the need for accurate information, individual variability in disease manifestations, prognostication of disease course, new developments in health technologies and personalized medicine, specialty care, pharmacological and non-pharmacological management, financial burden, lifestyle and work-related issues, support groups and palliative care...
January 2017: Current Neurology and Neuroscience Reports
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