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https://www.readbyqxmd.com/read/27895936/neovascular-glaucoma-a-review
#1
REVIEW
Gustavo B Rodrigues, Ricardo Y Abe, Camila Zangalli, Savio L Sodre, Flavia A Donini, Danilo C Costa, Andre Leite, Joao P Felix, Marcelo Torigoe, Alberto Diniz-Filho, Homero Gusmão de Almeida
Neovascular glaucoma (NVG) is a secondary glaucoma generally associated with poor visual prognosis. The development of new vessels over the iris and the iridocorneal angle can obstruct aqueous humor outflow and lead to increased intraocular pressure. The underlying pathogenesis in most cases is posterior segment ischemia, which is most commonly secondary to proliferative diabetic retinopathy or central vein retinal occlusion. The neovascularization process in the eye is driven by the events that alter the homeostatic balance between pro-angiogenic factors, such as the vascular endothelial growth factor and anti-angiogenic factors, such as the pigment-epithelium-derived factor...
2016: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/27881907/retinal-safety-of-intravitreal-rtpa-in-healthy-rats-and-under-excitotoxic-conditions
#2
Alejandra Daruich, Jérôme Parcq, Kimberley Delaunay, Marie-Christine Naud, Quentin Le Rouzic, Emilie Picard, Patricia Crisanti, Denis Vivien, Marianne Berdugo, Francine Behar-Cohen
PURPOSE: Intravitreal recombinant tissue plasminogen activator (rtPA) is used off-label for the surgical management of submacular hemorrhage, a severe complication of neovascular age-related macular degeneration. rtPA is approved for coronary and cerebral thrombolysis. However, in ischemic stroke rtPA is known to increase excitotoxic neural cell death by interacting with the N-methyl-D-aspartate (NMDA) receptor. We therefore investigated the retinal toxicity of rtPA in healthy rats and in a model of NMDA-induced retinal excitotoxicity...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27860442/primary-rhegmatogenous-retinal-detachment-surgical-methods-and-anatomical-outcome
#3
Marta Haugstad, Stefan Moosmayer, Ragnheiður Bragadόttir
PURPOSE: The aim of the study was to evaluate the anatomical success of surgical management of primary rhegmatogenous retinal detachment (RRD) and to compare the anatomical outcomes from different surgical techniques. METHODS: During 2012, 517 consecutive eyes (514 patients) were operated by 11 surgeons at the Department of Ophthalmology, Oslo University Hospital. Patient records were retrospectively analysed with no exclusions. Main outcome measures were primary and final anatomical success...
November 18, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27831970/spontaneous-closure-of-a-macular-hole-after-four-failed-vitrectomies-in-the-setting-of-nf-1
#4
Kendall W Wannamaker, Robert A Sharpe, Jan A Kylstra
PURPOSE: To present the case of a patient who developed spontaneous closure of an idiopathic macular hole after four failed attempts at surgical closure. METHODS: This is a retrospective case review of the medical record of a single patient. No statistical analysis was performed. The patient is a 71-year-old white woman with neurofibromatosis Type 1 who presented to the retina clinic of one of the authors. RESULTS: The patient underwent four vitrectomies with long acting gas by two surgeons over the course of 2 years...
November 9, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27828909/incomplete-repair-of-retinal-structure-after-vitrectomy-with-internal-limiting-membrane-peeling
#5
Toshio Hisatomi, Takashi Tachibana, Shoji Notomi, Shunji Nakatake, Kohta Fujiwara, Yusuke Murakami, Yasuhiro Ikeda, Shigeo Yoshida, Hiroshi Enaida, Toshinori Murata, Taiji Sakamoto, Koh-Hei Sonoda, Tatsuro Ishibashi
PURPOSE: To examine retinal changes after vitrectomy with internal limiting membrane (ILM) peeling, we used a cynomolgus monkey model and focused on surgical damages of ILM peeling for long observational period of 3 years. METHODS: Vitrectomy was performed followed by ILM peeling similar to clinical settings in humans. Ultrastructural changes of the retina were investigated by light, transmission, and scanning electron microscopy at 3 months and 3 years after ILM peeling...
November 8, 2016: Retina
https://www.readbyqxmd.com/read/27818205/histopathologic-analysis-of-trans-vitreal-fine-needle-aspiration-biopsy-needle-tracts-for-uveal-melanoma
#6
Ryan S Kim, Patricia Chevez-Barrios, Maria E Bretana, Tien P Wong, Bin S Teh, Amy C Schefler
PURPOSE: Perform the first in vivo examination of fine needle aspiration biopsy scleral tracts to determine the incidence of iatrogenic extension of tumor cells. DESIGN: A prospective, consecutive, observational case series. METHODS: Setting: Clinical/surgical setting at Retina Consultants of Houston and Houston Methodist Hospital, Houston, TX. PARTICIPANTS: Ten patients who were scheduled for enucleation as primary treatment for uveal melanoma...
November 3, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800245/chemotherapy-in-retinoblastoma-current-approaches
#7
REVIEW
Özge Yanık, Kaan Gündüz, Kıvılcım Yavuz, Nurdan Taçyıldız, Emel Ünal
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. Although enucleation and external beam radiotherapy have been historically used, today the most commonly used eye-sparing approach is chemotherapy. Chemotherapy can be used in both intraocular and extraocular RB cases. Chemotherapeutic agents may be applied in different ways, including systemic, subconjunctival, intra-arterial and intravitreal routes. The main purposes of application of systemic therapy are to reduce the tumor size for local treatment (chemoreduction), or to reduce the risk of metastasis after enucleation surgery (adjuvant therapy)...
December 2015: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27790129/transmuscular-migration-of-a-scleral-tunnel-secured-encircling-silicone-band
#8
Yui Nishida, Masanori Fukumoto, Teruyo Kida, Hiroyuki Suzuki, Tsunehiko Ikeda
The migration of an encircling silicone band through a rectus muscle is a rare postoperative complication associated with scleral buckling surgery for retinal detachment. In this present study, we describe what we believe to be the first reported case of a patient who experienced postoperative migration of an encircling silicone band through the rectus muscle, despite the band being surgically secured to the sclera in a scleral tunnel. A 58-year-old man presented with a rhegmatogenous retinal detachment in his left eye...
September 2016: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/27787448/smoking-is-a-risk-factor-for-proliferative-vitreoretinopathy-after-traumatic-retinal-detachment
#9
Dean Eliott, Tomasz P Stryjewski, Michael T Andreoli, Christopher M Andreoli
PURPOSE: To determine the incidence of retinal redetachment due to proliferative vitreoretinopathy after open-globe trauma in smokers and nonsmokers. METHODS: A total of 892 patients comprising 893 open-globe injuries, in whom 255 eyes were diagnosed with a retinal detachment, and 138 underwent surgical repair were analyzed in a retrospective case-control study. Time to redetachment was examined using the Kaplan-Meier method and analysis of risk factors was analyzed using Cox proportional hazards modeling...
October 26, 2016: Retina
https://www.readbyqxmd.com/read/27786583/the-efficacy-and-safety-profile-of-ocriplasmin-in-vitreomacular-interface-disorders
#10
Mehrine Shaikh, John B Miller, Thanos D Papakostas, Deeba Husain
Vitreomacular adhesion (VMA) describes the adhesion of the posterior hyaloid face to the inner retina in any part of the macula. This can arise after incomplete separation of the posterior vitreous cortex from the macula during vitreous liquefaction. While the VMA may resolve spontaneously, a strong and persistent adhesion can lead to a variety of anatomical changes, including vitreomacular traction (VMT) and macular hole (MH). Both conditions can present with metamorphopsia and decreased vision. In cases of symptomatic VMT and full-thickness macular hole, pars plana vitrectomy has long been the standard of care...
October 27, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27781127/timing-of-pars-plana-vitrectomy-in-management-of-gunshot-perforating-eye-injury-observational-study
#11
Hammouda Hamdy Ghoraba, Mohamed Amin Heikal, Hosam Osman Mansour, Haithem Mamon Abdelfattah, Emad Mohamed Elgemai, Adel Galal Zaky
The aim of this study is to report the difference in either anatomical or functional outcome of vitreoretinal intervention in cases of gunshot perforating eye injury if done 2-4 weeks or after the 4th week after the original trauma. Patients were treated with pars plana vitrectomy and silicon oil. Surgeries were performed in the period from February 2011 until the end of December 2014. 253 eyes of 237 patients were reviewed. 46 eyes were excluded. 207 eyes of 197 patients were analyzed. The included eyes were classified based on the timing of vitrectomy in relation to the initial trauma into two groups: 149 eyes (the first group) operated on between the 3rd and the 4th week and 58 eyes (the second group) operated on after the 4th week after the trauma...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27778476/a-minimally-invasive-adjustable-depth-blunt-injector-for-delivery-of-pharmaceuticals-into-the-posterior-pole
#12
Ygal Rotenstreich, Adi Tzameret, Sapir E Kalish, Ettel Bubis, Michael Belkin, Iris Moroz, Mordechai Rosner, Itay Levy, Shlomo Margel, Ifat Sher
PURPOSE: To investigate the feasibility and safety of a novel minimally invasive adjustable-depth blunt injector for pharmaceuticals delivery into the posterior segment. METHODS: Indocyanine green (ICG), sodium fluorescein and iron oxide nanoparticles (IONPs) were injected using the new injector into the extravascular spaces of the choroid (EVSC) compartment of rabbits and cadaver pig eyes. Spectral domain optical coherence tomography (SD-OCT), fundus imaging and histology analysis were performed for assessment of injection safety and efficacy...
October 25, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27759861/dehydrated-allogenic-human-amniotic-membrane-graft-for-conjunctival-surface-reconstruction-following-removal-of-exposed-scleral-buckle
#13
Dilraj S Grewal, Tamer H Mahmoud
A 54-year-old male developed symptomatic scleral buckle exposure 16 years after placement and presented with large conjunctival defects with fibrosed edges. Following surgical removal of the buckle elements, primary conjunctival closure could not be achieved due to significant wound tension despite undermining the conjunctival edges to mobilize the conjunctiva. A dehydrated amniotic membrane graft (Ambio5; IOP Ophthalmics, Costa Mesa, CA) was placed on the scleral bed and secured in place with fibrin sealant (TISSEEL; Baxter International, Westlake Village, CA)...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27759708/treatment-of-macular-folds-complicating-retinal-detachment-surgery-using-air-for-retinal-unfolding
#14
Pierre-Olivier Barale, Paolo Mora, Marie-Hélène Errera, Raphaëlle Ores, Michel Pâques, José-Alain Sahel
PURPOSE: We discuss a modified surgical procedure for the treatment of macular folds complicating retinal reattachment surgery. METHODS: To facilitate the completion of the macular redetachment and the subsequent unrolling of the fold, we propose the subretinal injection, in addition to the conventional balanced salt solution, of filtered air as an original approach. In the presence of a subretinal air bubble, the action of gravity on the perfluorocarbon liquid in the vitreous cavity combined with an active globe manipulation proved to be very effective for flattening the central retina...
October 18, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27754738/noninvasive-electroretinography-assessment-of-intravitreal-sustained-release-methotrexate-microimplants-in-rabbit-eyes
#15
Soumyarwit Manna, James J Augsburger, Zelia M Correa, Marwan F Al-Rjoub, Marepalli B Rao, Rupak K Banerjee
PURPOSE: The purpose of this study is to noninvasively evaluate the safety and toxicity of a chitosan (CS) and polylactic acid (PLA)-based sustained-release methotrexate (MTX) intravitreal microimplant in normal rabbit eyes using electroretinography (ERG). METHODS: PLA-coated CS-based microimplants containing 400 μg of MTX and placebo microimplants (without drug) were surgically implanted in the vitreous of the right and the left eyes, respectively, in each of the 8 New Zealand rabbits using minimally invasive technique...
October 18, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27750461/evaluation-of-dose-and-safety-of-aav7m8-and-aav8bp2-in-the-non-human-primate-retina
#16
Pavitra Ramachandran, Vivian Lee, Zhangyong Wei, Ji Yun Song, Giulia Casal, Therese Cronin, Keirnan Willett, Rachel Huckfeldt, Jessica I W Morgan, Tomas S Aleman, Albert M Maguire, Jean Bennett
Within the next decade, we will see many gene therapy clinical trials for eye diseases progress, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recombinant adeno-associated virus (AAV) serotypes have been generated and used successfully in pre-clinical mouse studies. Because there are numerous anatomic, and physiologic differences between the eyes of mice and 'men' and because surgical delivery approaches and immunologic responses also differ between these species, we evaluated the transduction characteristics of two promising new serotypes AAV7m8 and AAV8BP2, in retinas of animals that are most similar to those of humans: non-human primates (NHPs)...
October 18, 2016: Human Gene Therapy
https://www.readbyqxmd.com/read/27749794/can-peripheral-optical-coherence-tomography-b-scans-influence-the-surgeon-s-decision-on-episcleral-surgery
#17
Micol Alkabes, Domenico Massaro, Stefano Ranno, Paolo Nucci
PURPOSE: To describe the case of a young boy affected by a rhegmatogenous retinal redetachment in whom the use of peripheral optical coherence tomography led the vitreoretinal surgeon to treat the patient with an additional surgery instead of a "watchful waiting" strategy. METHODS: A 13-year-old boy was referred to the Vitreoretinal Department of the study institution affected by a macula-off rhegmatogenous retinal redetachment in his right eye secondary to a second blunt trauma...
October 3, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27749793/iatrogenic-choroidal-neovascular-membrane-in-macular-hole-induced-retinal-detachment
#18
Ramesh Venkatesh, Prachi Gurav, Prachi A Dave
PURPOSE: To report a case of choroidal neovascular membrane after vitreoretinal surgery in a patient with macular hole-induced retinal detachment. METHODS: Retrospective observational case report. CASE DESCRIPTION: A 64-year-old lady presented with sudden drop in vision in the right eye since 20 days. Her best-corrected visual acuity was 6/36 in the right eye and 6/18 in the left eye. She was diagnosed with retinal detachment with a macular hole in the right eye...
October 3, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27635064/long-term-functional-results-following-vitrectomy-for-advanced-retinopathy-of-prematurity
#19
Murat Karacorlu, Mumin Hocaoglu, Isil Sayman Muslubas, Serra Arf
PURPOSE: To assess long-term functional results after vitrectomy for stages 4 and 5 retinopathy of prematurity (ROP). METHODS: Retrospective analysis of data from eyes that underwent lens-sparing vitrectomy (LSV) or combined lensectomy and vitrectomy (LV) and had a follow-up of at least 5 years. RESULTS: Eighty-eight eyes of 65 infants who underwent LSV or LV for stage 4 or 5 ROP were included in the study. The mean follow-up was 6.9 years...
September 15, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27631480/characteristics-and-outcomes-of-simultaneous-bilateral-rhegmatogenous-retinal-detachments
#20
Avni P Finn, Dean Eliott, Leo A Kim, Deeba Husain, David M Wu, Lucy H Y Young, Ivana K Kim, Christopher Andreoli, Dimitra Skondra, Demetrios G Vavvas, John B Miller
BACKGROUND AND OBJECTIVE: To better understand the clinical course and outcomes of simultaneous bilateral retinal detachments managed by modern vitreoretinal surgical techniques. PATIENTS AND METHODS: A retrospective review of 21 patients (42 eyes) presenting between April 2000 and June 2015 with simultaneous bilateral rhegmatogenous retinal detachments. RESULTS: Mean visual acuity (VA) improved from 20/100 at presentation to 20/40 at last follow-up (P = ...
September 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
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