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https://www.readbyqxmd.com/read/29676228/glaucoma-pathogenesis-and-neurotrophins-focus-on-the-molecular-and-genetic-basis-for-therapeutic-prospects
#1
Nitin Chitranshi, Yogita Dheer, Mojdeh Abbasi, Yuyi You, Stuart L Graham, Vivek Gupta
BACKGROUND: Retinal ganglion cell (RGC) degeneration is a major feature of glaucoma pathology. Neuroprotective approaches that delay or halt the progression of RGC loss are needed to prevent vision loss which can occur even after conventional medical or surgical treatments to lower intraocular pressure. OBJECTIVE: The aim of this review was to examine the progress in genetics and cellular mechanisms associated with endoplasmic reticulum (ER) stress, RGC dysfunction and cell death pathways in glaucoma...
April 19, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29675776/pluripotent-stem-cells-for-retinal-tissue-engineering-current-status-and-future-prospects
#2
REVIEW
Ratnesh Singh, Oscar Cuzzani, François Binette, Hal Sternberg, Michael D West, Igor O Nasonkin
The retina is a very fine and layered neural tissue, which vitally depends on the preservation of cells, structure, connectivity and vasculature to maintain vision. There is an urgent need to find technical and biological solutions to major challenges associated with functional replacement of retinal cells. The major unmet challenges include generating sufficient numbers of specific cell types, achieving functional integration of transplanted cells, especially photoreceptors, and surgical delivery of retinal cells or tissue without triggering immune responses, inflammation and/or remodeling...
April 19, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29673275/predicting-surgical-success-in-patients-with-idiopathic-epiretinal-membrane-using-the-spectral-domain-optical-coherence-tomography-segmentation-module-for-single-retinal-layer-analysis
#3
Robert Kromer, Clara Vogt, Lars Wagenfeld, Martin Stephan Spitzer, Birthe Stemplewitz
Introduction Idiopathic epiretinal membrane (ERM) is a proliferation of cells formed on the internal surface of the retina and may cause a slow decrease in visual acuity (VA). The aim of this study was to evaluate the individual layers of the retina by optical coherence tomography (OCT) before and after vitrectomy with ERM peeling in order to refine surgical decision-making. Methods Forty-seven eyes of 45 patients (aged 55-87 years) with ERM were enrolled retrospectively from a tertiary referral centre. OCT examination was performed preoperatively and at a mean of 3...
April 19, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29671948/best-surgical-technique-and-outcomes-for-large-macular-holes-retrospective-multicentre-study-in-japan
#4
REVIEW
Toshifumi Yamashita, Taiji Sakamoto, Hiroto Terasaki, Masanori Iwasaki, Yoko Ogushi, Fumiki Okamoto, Masaru Takeuchi, Tsutomu Yasukawa, Yoshihiro Takamura, Nahoko Ogata, Yumiko Nakamura
The purpose of this study was to compare the surgical outcomes of vitrectomy with conventional internal limiting membrane (C-ILM) peeling to that with the inverted ILM (I-ILM) flap technique for large macular holes (MHs). This was a retrospective chart review of consecutive cases with a large MH at nine hospitals in Japan. Among the 1342 eyes, 165 eyes of 165 cases met the inclusion criteria. The results for medium-large MHs with a diameter 400-550 μm were compared to that of eyes with an extra-large MH with a diameter >550 μm...
April 19, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29670325/retinal-detachment-in-albinism
#5
Ahmad M Mansour, Jay Chhablani, J Fernando Arevalo, Lihteh Wu, Ravi Sharma, Suthasinee Sinawat, Tharikarn Sujirakul, Alexandre Assi, Wandsy M Vélez-Vázquez, Mohamad A Mansour, Ozcan Kayikcioglu, Cem Kucukerdonmez, Ali Kal
Purpose: To report the visual and anatomic outcomes of albino retinal detachment (ARD) repair. Methods: Collaborative retrospective analysis of ARD. Outcome measures were number of surgical interventions, final retinal reattachment, and best corrected visual acuity (BCVA) at last follow-up. Results: Seventeen eyes of 16 patients (12 males; mean age =37.8 years) had the following complications at presentation: macula off (14), total (7) or inferior detachment (5), proliferative vitreoretinopathy (5), detectable break (16), lattice (5), horseshoe tears (9), and giant tear or dialysis (4)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29664988/peripheral-vascular-abnormalities-seen-by-ultra-widefield-fluorescein-angiography-in-adults-with-history-of-prematurity-report-of-three-cases
#6
Linda Alejandra Cernichiaro-Espinosa, Basil K Williams, María A Martínez-Castellanos, Catherin I Negron, Audina M Berrocal
Retinopathy of prematurity (ROP) may lead to late-developing complications due to the abnormal vitreoretinal interface. In this case report, three adult patients (ages 39 years, 62 years, and 64 years) with a history of prematurity underwent imaging with ultra-widefield fluorescein angiography (UWFFA). The UWFFA demonstrated late peripheral vascular hyperfluorescence in all three patients, perivascular leakage in two of the patients, hyperfluorescent foveal avascular zone in two of the patients, peripheral avascular retina in two of the patients, vasoproliferative tumor in one of the patients, peripheral neovascularization in one of the patients, and vascular anastomosis in one of the patients...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29664984/pilot-evaluation-of-a-new-surgical-technique-for-persistent-or-recurrent-large-macular-holes
#7
Vito Primavera, Teresa Centoducati, Luciana Agea, Ilaria Zucchiatti, Lea Querques, Giuseppe Querques
BACKGROUND AND OBJECTIVE: To describe a new surgical technique for persistent or recurrent large macular holes (MHs). PATIENTS AND METHODS: Patients with recurrent or persistent large MHs following vitrectomy with internal limiting membrane (ILM) peeling were recruited between October and September 2017 in this pilot study. All patients underwent preoperative and postoperative best-corrected visual acuity (BCVA), slit-lamp ophthalmoscopy, and spectral-domain optical coherence tomography (SD-OCT)...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29664979/comparative-evaluation-of-standard-ilm-peel-with-inverted-ilm-flap-technique-in-large-macular-holes-a-prospective-randomized-study
#8
S Manasa, Prateek Kakkar, Atul Kumar, Parijat Chandra, Vinod Kumar, Raghav Ravani
BACKGROUND AND OBJECTIVE: To compare the outcomes of inverted internal limiting membrane (ILM) flap technique (IFT) with the standard ILM peel (SIP) for large macular holes (MHs). PATIENTS AND METHODS: This is a prospective, randomized study in which 100 patients with idiopathic MHs with minimum linear dimension of 600 μm or greater were recruited. Group 1 underwent SIP and group 2 underwent IFT. Best-corrected visual acuity (BCVA), type of MH closure, and multifocal electroretinogram (mfERG) were evaluated at presentation, 1 week, 1 month, and 3 months postoperatively...
April 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29643781/two-cases-of-rhegmatogenous-retinal-detachment-associated-with-asteroid-hyalosis
#9
Yoshitaka Okuda, Keigo Kakurai, Takaki Sato, Seita Morishita, Masanori Fukumoto, Ryohsuke Kohmoto, Mai Takagi, Takatoshi Kobayashi, Teruyo Kida, Tsunehiko Ikeda
Background: To report two cases of rhegmatogenous retinal detachment (RRD) associated with asteroid hyalosis (AH). Case Presentation: Two patients presented with RRD originating from a flap tear. Case 1 involved a 62-year-old male who was found to have bullous RRD in his left eye originating from a flap tear. During vitreous surgery, a thick vitreous cortex was found to have strongly adhered to the entire retinal surface, from the center to the periphery. A bimanual method was then used in conjunction with the vitrectomy to create an artificial posterior vitreous detachment...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29606853/the-role-of-corneal-hysteresis-during-the-evaluation-of-patients-with-possible-normal-tension-glaucoma
#10
Ming Chen, Laura Kueny, Arthur L Schwartz
Purpose: There are multiple reports of the role of corneal hysteresis (CH) as an independent risk factor for the diagnosis and risk of progression of normal-tension glaucoma (NTG). Our study measured CH with the Ocular Response Analyzer (ORA) in patients with intraocular pressure (IOP) <21 mmHg to investigate if a low CH would identify NTG in this Asian-based practice. Methods: This was a prospective cross-sectional study of patients who underwent routine eye examination during 2016 in a private practice in Honolulu, Hawaii, where most patients are Asian...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29606378/the-globe-s-eccentric-rotational-axis-why-medial-rectus-surgery-is-more-potent-than-lateral-rectus-surgery
#11
Robert A Clark, Joseph L Demer
PURPOSE: Tables typically recommend greater lateral rectus (LR) than medial rectus (MR) surgical doses for horizontal strabismus of any given magnitude, a difference unexplained by mechanical models that assume globe rotation about its center. We tested this assumption during horizontal ductions. DESIGN: Prospective observational study. PARTICIPANTS: Eighteen adult subjects with normal binocular vision. METHODS: Surface coil magnetic resonance imaging at 390 or 430 μm resolution was obtained using 2-mm-thick contiguous axial planes while subjects fixated targets in central, right, and left gaze...
March 29, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29587974/macular-photostress-and-visual-experience-between-microscope-and-intracameral-illumination-during-cataract-surgery
#12
Hyejin Seo, Dong Heun Nam, Jong Yeon Lee, Su Jin Park, Yu Jeong Kim, Seong-Woo Kim, Tae-Young Chung, Makoto Inoue, Terry Kim
PURPOSE: To evaluate macular photostress and visual experience between coaxial microscope illumination versus oblique intracameral illumination during cataract surgery. SETTING: Gachon University Gil Hospital, Incheon, South Korea. DESIGN: Prospective case series. METHODS: Consecutive patients who had cataract surgery using microscope illumination and intracameral illumination were included. The patients were asked to complete a questionnaire (seeing strong lights, feeling photophobia, feeling startled (fright) when seeing lights, seeing any colors, seeing any instruments or surgical procedures, and estimating intraoperative visual function) designed to describe their cataract surgery experience...
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29573745/monocular-enucleation-alters-retinal-waves-in-the-surviving-eye
#13
Samuel Wilson Failor, Arash Ng, Hwai-Jong Cheng
BACKGROUND: Activity in neurons drives afferent competition that is critical for the refinement of nascent neural circuits. In ferrets, when an eye is lost in early development, surviving retinogeniculate afferents from the spared eye spread across the thalamus in a manner that is dependent on spontaneous retinal activity. However, how this spontaneous activity, also known as retinal waves, might dynamically regulate afferent terminal targeting remains unknown. METHODS: We recorded retinal waves from retinae ex vivo using multi-electrode arrays...
March 24, 2018: Neural Development
https://www.readbyqxmd.com/read/29543200/-evaluation-of-yag-laser-vitreolysis-effectiveness-based-on-quantitative-characterization-of-vitreous-floaters
#14
V A Shaimova, T B Shaimov, R B Shaimov, A Yu Galin, Zh A Goloshchapova, P K Ryzhkov, A V Fomin
PURPOSE: To develop methods for evaluating effectiveness of YAG-laser vitreolysis of vitreous floaters. MATERIAL AND METHODS: The study included 144 patients (173 eyes) who had underwent YAG-laser vitreolysis and were under observation from 01.09.16 to 31.01.18. The patients were 34 to 86 years old (mean age 62.7±10.2 years), 28 (19.4%) patients were male, 116 (80.6%) - female. All patients underwent standard and additional examination: ultrasonography (Accutome B-scan plus, U...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29543193/-electrophysiological-characteristics-of-the-retina-in-children-with-cicatrical-retinopathy-of-prematurity
#15
O A Konikova, V V Brzhesky
Visual impairment in children with regressive retinopathy of prematurity (ROP) are diverse and widespread. PURPOSE: to describe the electrophysiological characteristics of the retina in children with I-V stages of regressive ROP. MATERIAL AND METHODS: The study included children with stages I-V aged 5 to 17 (in the disease stages of IV and V - with reattachment of the retina after surgical treatment of its detachment). Patients with concomitant diseases of the eye were excluded from the study...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29528862/implantation-removal-and-replacement-of-subretinal-electronic-implants-for-restoration-of-vision-in-patients-with-retinitis-pigmentosa
#16
Katrin Gekeler, Karl Ulrich Bartz-Schmidt, Helmut Sachs, Robert E MacLaren, Katarina Stingl, Eberhart Zrenner, Florian Gekeler
PURPOSE OF REVIEW: The purpose of this review is to provide an update on the efforts to restore vision through subretinal implants in patients with degenerative retinal diseases. In addition to the current technique and its latest improvements, it will focus on the surgical technique of implantation as well as explantation and reimplantation. RECENT FINDINGS: The durability of the current subretinal implant RETINA IMPLANT Alpha AMS has increased substantially compared with the predecessor model RETINA IMPLANT Alpha IMS...
March 9, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29527537/robot-assisted-vitreoretinal-surgery-current-perspectives
#17
Marina Roizenblatt, Thomas L Edwards, Peter L Gehlbach
Vitreoretinal microsurgery is among the most technically challenging of the minimally invasive surgical techniques. Exceptional precision is required to operate on micron scale targets presented by the retina while also maneuvering in a tightly constrained and fragile workspace. These challenges are compounded by inherent limitations of the unassisted human hand with regard to dexterity, tremor and precision in positioning instruments. The limited human ability to visually resolve targets on the single-digit micron scale is a further limitation...
2018: Robotic Surgery: Research and Reviews
https://www.readbyqxmd.com/read/29524202/a-case-report-of-conservative-management-for-a-roller-coaster-related-vitreous-haemorrhage
#18
Alexander James Brent, Abdul R El-Khayat, Shamfa A M Peart, Somnath Banerjee
The purpose of this report is to describe the case and management of an unexplained vitreous haemorrhage that occurred after repeated roller-coaster riding. The authors inadvertently demonstrate the value of observation over immediate surgery in certain situations and review the literature on vitreoretinal and other ocular complications after roller-coaster riding. A 26-year-old male presented 12 h after riding high-velocity roller-coasters with a left vitreous haemorrhage. A hazy view of the retina and B-scan revealed a bullous area of superior-temporal retinal lifting...
March 9, 2018: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/29521688/keratoprosthesis-decentration-and-tilt-results-in-degradation-in-image-quality
#19
Richard W Helms, Xiaowei Zhao, Rony R Sayegh
PURPOSE: To study the effect of decentration and tilt of the type I Boston keratoprosthesis (KPro) on image quality in both aphakic and pseudophakic eyes. METHODS: An optical ray-tracing program was used to simulate the image projected onto the retina in an eye with a perfectly centered KPro, and in eyes with varying degrees of KPro decentration and tilt. Decentration was modeled along a typical white-to-white distance of 12.0 mm, and the corresponding tilt was calculated assuming a radius of curvature of 8...
March 6, 2018: Cornea
https://www.readbyqxmd.com/read/29503449/cellular-regeneration-strategies-for-macular-degeneration-past-present-and-future
#20
REVIEW
Valeria Chichagova, Dean Hallam, Joseph Collin, Darin Zerti, Birthe Dorgau, Majed Felemban, Majlinda Lako, David H Steel
Despite considerable effort and significant therapeutic advances, age-related macular degeneration (AMD) remains the commonest cause of blindness in the developed world. Progressive late-stage AMD with outer retinal degeneration currently has no proven treatment. There has been significant interest in the possibility that cellular treatments may slow or reverse visual loss in AMD. A number of modes of action have been suggested, including cell replacement and rescue, as well as immune modulation to delay the neurodegenerative process...
March 5, 2018: Eye
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