keyword
https://read.qxmd.com/read/38155461/genetic-mutation-of-tas2r104-tas2r105-tas2r114-cluster-leads-to-a-loss-of-taste-perception-to-denatonium-benzoate-and-cucurbitacin-b
#21
JOURNAL ARTICLE
Bowen Niu, Lingling Liu, Qian Gao, Meng-Min Zhu, Lixiang Chen, Xiu-Hua Peng, Boying Qin, Xiaohui Zhou, Feng Li
BACKGROUND: Bitter taste receptors (Tas2rs) are generally considered to sense various bitter compounds to escape the intake of toxic substances. Bitter taste receptors have been found to widely express in extraoral tissues and have important physiological functions outside the gustatory system in vivo. METHODS: To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues, multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene-editing technique...
December 28, 2023: Animal Models and Experimental Medicine
https://read.qxmd.com/read/38148243/integrative-transcriptome-and-whole-genome-bisulfite-sequencing-analyses-of-a-temperature-sensitive-albino-tea-plant-cultivar
#22
JOURNAL ARTICLE
Kexin Zhang, Xia Feng, Ying Liu, Yajun Yang, Xinyuan Hao, Dongliang Li, Xinchao Wang, Lu Wang
Green tea made from albino buds and leaves has a strong umami taste and aroma. The cultivar 'Zhonghuang 2' (ZH2, Camellia sinensis) is a natural mutant with young shoots that are yellow in spring and green or yellow-green in summer. However, the mechanism of leaf color change remains unclear. Here, we found that young shoots of ZH2 were yellow at low temperature (LT) and green at high temperature (HT), indicating that ZH2 is a temperature-sensitive cultivar. Transmission electron microscopy analysis showed that the grana in the chloroplasts of young shoots grown at LT were poorly stacked, which caused a lack of photoreactions and chlorophyll...
2023: Physiologia Plantarum
https://read.qxmd.com/read/38145006/long-term-dysfunction-of-taste-papillae-in-sars-cov-2
#23
JOURNAL ARTICLE
Qin Yao, Máire E Doyle, Qing-Rong Liu, Ashley Appleton, Jennifer F O'Connell, Nan-Ping Weng, Josephine M Egan
BACKGROUND: We sought to determine whether ongoing taste disturbance in the postacute sequelae of coronavirus disease 2019 period is associated with persistent virus in primary taste tissue. METHODS: We performed fungiform papillae biopsies on 16 patients who reported taste disturbance lasting more than 6 weeks after molecularly determined severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Then, on multiple occasions, we rebiopsied 10 of those patients who still had taste complaints for at least 6 months postinfection...
September 2023: NEJM Evid
https://read.qxmd.com/read/38136926/lingual-ultrastructural-and-histochemical-study-in-the-patagonian-mara-rodentia-caviidae-dolichotis-patagonum-in-relation-to-other-hystricomorphs
#24
JOURNAL ARTICLE
Petr Čížek, Karolina Goździewska-Harłajczuk, Pavla Hamouzová, Joanna Klećkowska-Nawrot, Pavel Kvapil
The study describes the ultrastructure of the tongue in the Patagonian mara ( Dolichotis patagonum ) using light and scanning electron microscopy. Histochemical methods were used for evaluation of lingual salivary glands. The tongue is divided into a small and rounded apex, a narrow corpus, and a significantly wider radix, with a well-developed lingual prominence. The tip of the apex is free of papillae. The caudal part of the apex and the corpus are covered by filiform papillae. Round fungiform papillae are scattered among them...
December 18, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38128683/chronic-social-defeat-stress-broadly-inhibits-gene-expression-in-the-peripheral-taste-system-and-alters-taste-responses-in-mice
#25
JOURNAL ARTICLE
Katelyn Tu, Mary Zhou, Jidong J Tan, Loza Markos, Cameron Cloud, Minliang Zhou, Naoki Hayashi, Nancy E Rawson, Robert F Margolskee, Hong Wang
Human studies have linked stress exposure to unhealthy eating behavior. However, the mechanisms that drive stress-associated changes in eating behavior remain incompletely understood. The sense of taste plays important roles in food preference and intake. In this study, we use a chronic social defeat stress (CSDS) model in mice to address whether chronic stress impacts taste sensation and gene expression in taste buds and the gut. Our results showed that CSDS significantly elevated circulating levels of corticosterone and acylated ghrelin while lowering levels of leptin, suggesting a change in metabolic hormones that promotes food consumption...
December 19, 2023: Physiology & Behavior
https://read.qxmd.com/read/38123367/antillean-manatee-trichechus-manatus-manatus-linnaeus-1758-tongue-morphology-and-adaptive-herbivorous-implications
#26
JOURNAL ARTICLE
Lucas Inácio Dos Santos Melo, Radan Elvis Matias de Oliveira, Ana Caroline Freitas Caetano de Sousa, Rysónely Maclay de Oliveira, Mariana Almeida Lima, Ana Bernadete Lima Fragoso, Flávio José de Lima Silva, Fernanda Loffler Niemeyer Attademo, Fábia de Oliveira Luna, Alexsandra Fernandes Pereira, Moacir Franco de Oliveira
Morphological study of the tongue is an interesting way of understanding evolutionary processes associated with feeding habits. Therefore, the aim of the present study was to describe the tongue morphology of the Antillean manatee and to understand possible morphological relationships with its way of capturing food. Macroscopic dissections and light and scanning electron microscopy analyses of seven manatee tongues were performed. The tongue in Antillean manatees is a muscular and robust organ, divided into apex, body, and root...
December 20, 2023: Microscopy and Microanalysis
https://read.qxmd.com/read/38092979/characterization-of-dysgeusia-and-xerostomia-in-patients-with-multiple-myeloma-treated-with-the-t-cell-redirecting-gprc5d-bispecific-antibody-talquetamab
#27
JOURNAL ARTICLE
A M G A Laheij, N W C J van de Donk
PURPOSE: In recent years, various immunotherapies have improved the survival of patients with multiple myeloma (MM). However, there remains an unmet need for novel agents. Talquetamab is the first-in-class GPRC5D-targeting T-cell redirecting bispecific antibody, which has substantial activity in advanced MM. Rapidly after the start of talquetamab treatment, patients reported taste changes (dysgeusia; 60% of patients), and a feeling of dry mouth (xerostomia; 30-57% of patients), which may be related to expression of the target antigen in healthy tissues, such as taste buds...
December 14, 2023: Supportive Care in Cancer
https://read.qxmd.com/read/38039795/delineation-of-the-healthy-rabbit-tongue-by-immunohistochemistry-a-technical-note
#28
JOURNAL ARTICLE
Gabriella Meier Bürgisser, Dorothea M Heuberger, Julia Rieber, Iris Miescher, Pietro Giovanoli, Maurizio Calcagni, Johanna Buschmann
In the oral cavity the tongue is an important muscular organ that supports the swallowing of food and liquids. It is responsible for the sense of taste, based on the many different taste buds it contains. Research in the field of tongue diseases demands for suitable preclinical models. The healthy rabbit tongue may therefore serve as baseline and reference for the pathological situation. With this consideration, we covered the fixation and histological stainings as well as the immunohistochemical labelling of the healthy rabbit tongue...
November 30, 2023: Acta Histochemica
https://read.qxmd.com/read/37984223/age-related-morphological-and-ultrastructural-changes-in-the-palate-and-pharyngeal-masticatory-apparatus-of-grass-carp-ctenopharyngodon-idella-juveniles
#29
JOURNAL ARTICLE
Ahmed M Abdellatif, Samah Lashen, Ramadan M Kandyel, Mahmoud B Shoeib, Fatma A Madkour
Grass carp (Ctenopharyngodon idella or C. idella) is a Cyprinid fish frequently utilized for aquaculture, medical, and research purposes. In C. idella, the palate is followed by a well-developed pharyngeal masticatory apparatus. The latter consists of an upper chewing pad superimposing a paired set of teeth. The present study investigated morphological, morphometric, histochemical, and surface ultrastructural changes involving these structures in C. idella juveniles at three different timepoints namely 35 mm total length (TL; 59 days posthatching (dph); fry-fingerling transition), 70 mm TL (90 dph; fingerling), and 210 mm TL ( 365 dph: yearling)...
November 7, 2023: Tissue & Cell
https://read.qxmd.com/read/37975309/visualization-of-the-chemical-defense-molecule-formoside-binding-to-sensory-structures-in-a-model-fish-predator
#30
JOURNAL ARTICLE
Samantha J Mascuch, Bhuwan Khatri Chhetri, Nazia Mojib, Julia Kubanek
Sensory perception of chemical threats coming from an organism's environment relies on the coordination of numerous receptors and cell types. In many cases, the physiological processes responsible for driving behavioral responses to chemical cues are poorly understood. Here, we investigate the physiological response of fish to an unpalatable compound, formoside, which is employed as a chemical defense by marine sponges. Construction of fluorescent probe derivatives of formoside allowed visualization of this chemical defense molecule in vivo, interacting with the cells and tissues of the early larvae of a model predator, the zebrafish (Danio rerio)...
November 17, 2023: Journal of Experimental Biology
https://read.qxmd.com/read/37966171/recent-advances-in-taste-transduction-mechanism-analysis-methods-and-strategies-employed-to-improve-the-taste-of-taste-peptides
#31
REVIEW
Chunyong Song, Zhijun Wang, Hanqi Li, Wenhong Cao, Zhongqin Chen, Huina Zheng, Jialong Gao, Haisheng Lin, Guoping Zhu
Taste peptides are oligopeptides that enhance both aroma and taste of food, and they are classified into five categories based on their taste characteristics: salty, sour, umami, sweet, bitter, and kokumi peptide. Recently, taste peptides have attracted the attention of several fields of research in food science and commercial applications. However, research on taste receptors of taste peptides and their taste transduction mechanisms are not clearly understood and we present a comprehensive review about these topics here...
November 15, 2023: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/37958598/vimentin-localization-in-the-zebrafish-oral-cavity-a-potential-role-in-taste-buds-regeneration
#32
JOURNAL ARTICLE
Marialuisa Aragona, Caterina Porcino, Marilena Briglia, Kamel Mhalhel, Francesco Abbate, Maria Levanti, Giuseppe Montalbano, Rosaria Laurà, Eugenia Rita Lauriano, Antonino Germanà, Maria Cristina Guerrera
The morphology of the oral cavity of fish is related to their feeding habits. In this context, taste buds are studied for their ability to catch chemical stimuli and their cell renewal capacity. Vimentin RV202 is a protein employed as a marker for mesenchymal cells that can differentiate along different lineages and to self-renew, while Calretinin N-18 is employed as a marker of sensory cells, and ubiquitin is a protein crucial for guiding the fate of stem cells throughout development. In this study, a surface morphology investigation and an immunohistochemical analysis have been conducted...
October 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37958091/tongue-of-the-egyptian-endemic-bridled-skink-heremites-vittatus-olivier-1804-gross-electron-microscopy-histochemistry-and-immunohistochemical-analysis
#33
JOURNAL ARTICLE
Ramadan M Kandyel, Om Prakash Choudhary, Sahar H El-Nagar, Donald B Miles, Mohamed Abumandour
The present study used light and scanning electron microscopy to describe the integrative morphological description of the tongue and laryngeal mound of Heremites vittatus , an endemic lizard of Saharan Africa. Additionally, ultrastructure, histology, histochemistry, and immunohistochemical approaches were used to characterize the lingual apparatus adaptations. In the present study, Heremites vittatus consisted of a complex lingual papillary system in which the ventral apical surface of the foretongue comprised conical papillae...
October 26, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37955018/functional-mri-activation-of-the-nucleus-tractus-solitarius-after-taste-stimuli-at-ultra-high-field-a-proof-of-concept-single-subject-study
#34
JOURNAL ARTICLE
Antonietta Canna, Elena Cantone, Anne Roefs, Sieske Franssen, Anna Prinster, Elia Formisano, Francesco Di Salle, Fabrizio Esposito
Using ultra-high field (7 Tesla) functional MRI (fMRI), we conducted the first in-vivo functional neuroimaging study of the normal human brainstem specifically designed to examine neural signals in the Nucleus Tractus Solitarius (NTS) in response to all basic taste stimuli. NTS represents the first relay station along the mammalian taste processing pathway which originates at the taste buds in the oral cavity and passes through the thalamus before reaching the primary taste cortex in the brain. In our proof-of-concept study, we acquired data from one adult volunteer using fMRI at 1...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37936941/uncovering-the-complex-regulatory-network-of-spring-bud-sprouting-in-tea-plants-insights-from-metabolic-hormonal-and-oxidative-stress-pathways
#35
JOURNAL ARTICLE
Junwei Tang, Yao Chen, Chao Huang, Congcong Li, Yue Feng, Haoqian Wang, Changqing Ding, Nana Li, Lu Wang, Jianming Zeng, Yajun Yang, Xinyuan Hao, Xinchao Wang
The sprouting process of tea buds is an essential determinant of tea quality and taste, thus profoundly impacting the tea industry. Buds spring sprouting is also a crucial biological process adapting to external environment for tea plants and regulated by complex transcriptional and metabolic networks. This study aimed to investigate the molecular basis of bud sprouting in tea plants firstly based on the comparisons of metabolic and transcriptional profiles of buds at different developmental stages. Results notably highlighted several essential processes involved in bud sprouting regulation, including the interaction of plant hormones, glucose metabolism, and reactive oxygen species scavenging...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/37922096/effect-of-salivary-gland-removal-on-taste-preference-in-mice
#36
JOURNAL ARTICLE
Masataka Narukawa, Rina Matsuda, Ippei Watari, Takashi Ono, Takumi Misaka
To evaluate the effect of decreased salivary secretion on taste preference, we investigated taste preference for five basic tastes by a 48 h two-bottle preference test using a mouse model (desalivated mice) that underwent surgical removal of three major salivary glands: the parotid, submandibular, and sublingual glands. In the desalivated mice, the avoidance behaviors for bitter and salty tastes and the attractive behaviors for sweet and umami tastes were significantly decreased. We confirmed that saliva is necessary to maintain normal taste preference...
November 3, 2023: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/37919307/altered-peripheral-taste-function-in-a-mouse-model-of-inflammatory-bowel-disease
#37
JOURNAL ARTICLE
Guangkuo Dong, Khaylie Boothe, Lianying He, Yang Shi, Lynnette Phillips McCluskey
Increased sugar intake and taste dysfunction have been reported in patients with inflammatory bowel disease (IBD), a chronic disorder characterized by diarrhea, pain, weight loss and fatigue. It was previously unknown whether taste function changes in mouse models of IBD. Mice consumed dextran sodium sulfate (DSS) during three 7-day cycles to induce chronic colitis. DSS-treated mice displayed signs of disease, including significant weight loss, diarrhea, loss of colon architecture, and inflammation of the colon...
November 2, 2023: Scientific Reports
https://read.qxmd.com/read/37879363/standing-gustatory-papillae-biopsy-procedure-for-antemortem-diagnosis-of-equine-grass-sickness
#38
JOURNAL ARTICLE
Emilie Quéré, Christelle Volmer, Céline Mespoulhès-Rivière
OBJECTIVE: Diagnosing equine grass sickness (EGS) requires histopathological evidence of chromatolysis and/or neuronal loss in peripheral autonomic ganglia. Previous investigators performed postmortem biopsies of gustatory papillae located on the tongue and found chromatolytic subgemmal neurons in all 13 EGS horses. The present study aimed to design a standardized lingual biopsy sampling method through a transbuccal approach in healthy standing horses and assess the quality of the obtained samples, to allow antemortem diagnosis of EGS in clinical cases...
October 25, 2023: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/37875870/histological-and-ultrastructural-characterization-of-the-dorso-ventral-skin-of-the-juvenile-and-the-adult-starry%C3%A2-puffer-fish-arothron-stellatus-anonymous-1798
#39
JOURNAL ARTICLE
Fatma A Madkour, Ahmed M Abdellatif, Yassein A Osman, Ramadan M Kandyel
BACKGROUND: The starry puffer fish (Arothron stellatus, Anonymous, 1798) is a poisonous tetradontidae fish inhabiting the Red sea. The skin constitutes an important defense against any external effects. The study aims to characterize the dorso-ventral skin of the juvenile and the adult starry puffer fish using light and scanning electron microscopies. Twenty specimens of juvenile and adult fresh fishes were used. RESULTS: The scanning electron microarchitecture of the skin of the juvenile and adult fish showed delicate irregular-shaped protrusions, and well-defined bricks-like elevations on the dorsal side and interrupted folds as well as irregular-shaped protrusions on the ventral side...
October 24, 2023: BMC Veterinary Research
https://read.qxmd.com/read/37855652/-conspicuous-conditions-of-the-tongue-normal-variants-vs-pathological-findings
#40
JOURNAL ARTICLE
Martina Broglie Däppen, Günter Toman Müller, Thomas Gander
With its sensitivity, taste buds and complex anatomical structure of various muscles, the tongue is a central organ for speaking, tasting and food intake, especially oral food transport, chewing and swallowing. Changes in the tongue 's condition are frequent and often lead to uncertainty among patients and eventually to a visit to the family doctor, to the ear, nose and throat specialist, dentist or maxillofacial surgeon. The question whether the condition of the tongue is a lesion requiring treatment or just a variant can quite often prove a major challenge...
August 2023: Praxis
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