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https://www.readbyqxmd.com/read/25057203/eif2%C3%AE-dephosphorylation-in-basolateral-amygdala-mediates-reconsolidation-of-drug-memory
#1
Min Jian, Yi-Xiao Luo, Yan-Xue Xue, Ying Han, Hai-Shui Shi, Jian-Feng Liu, Wei Yan, Ping Wu, Shi-Qiu Meng, Jia-Hui Deng, Hao-Wei Shen, Jie Shi, Lin Lu
Maladaptive memories elicited by exposure to environmental stimuli associated with drugs of abuse are often responsible for relapse among addicts. Interference with the reconsolidation of drug memory can inhibit drug seeking. Previous studies have indicated that the dephosphorylation of the eukaryotic initiation factor 2 α-subunit (eIF2α) plays an important role in synaptic plasticity and long-term memory consolidation, but its role in the reconsolidation of drug memory remains unknown. The amygdala is required for the reconsolidation of a destabilized drug memory after retrieval of drug-paired stimuli...
July 23, 2014: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/22354021/regulation-of-subtilase-cytotoxin-induced-cell-death-by-an-rna-dependent-protein-kinase-like-endoplasmic-reticulum-kinase-dependent-proteasome-pathway-in-hela-cells
#2
Kinnosuke Yahiro, Hiroyasu Tsutsuki, Kohei Ogura, Sayaka Nagasawa, Joel Moss, Masatoshi Noda
Shiga-toxigenic Escherichia coli (STEC) produces subtilase cytotoxin (SubAB), which cleaves the molecular chaperone BiP in the endoplasmic reticulum (ER), leading to an ER stress response and then activation of apoptotic signaling pathways. Here, we show that an early event in SubAB-induced apoptosis in HeLa cells is mediated by RNA-dependent protein kinase (PKR)-like ER kinase (PERK), not activating transcription factor 6 (ATF6) or inositol-requiring enzyme 1(Ire1), two other ER stress sensors. PERK knockdown suppressed SubAB-induced eIF2α phosphorylation, activating transcription factor 4 (ATF4) expression, caspase activation, and cytotoxicity...
May 2012: Infection and Immunity
https://www.readbyqxmd.com/read/17418795/eif2alpha-phosphorylation-bidirectionally-regulates-the-switch-from-short-to-long-term-synaptic-plasticity-and-memory
#3
Mauro Costa-Mattioli, Delphine Gobert, Elad Stern, Karine Gamache, Rodney Colina, Claudio Cuello, Wayne Sossin, Randal Kaufman, Jerry Pelletier, Kobi Rosenblum, Kresimir Krnjević, Jean-Claude Lacaille, Karim Nader, Nahum Sonenberg
The late phase of long-term potentiation (LTP) and memory (LTM) requires new gene expression, but the molecular mechanisms that underlie these processes are not fully understood. Phosphorylation of eIF2alpha inhibits general translation but selectively stimulates translation of ATF4, a repressor of CREB-mediated late-LTP (L-LTP) and LTM. We used a pharmacogenetic bidirectional approach to examine the role of eIF2alpha phosphorylation in synaptic plasticity and behavioral learning. We show that in eIF2alpha(+/S51A) mice, in which eIF2alpha phosphorylation is reduced, the threshold for eliciting L-LTP in hippocampal slices is lowered, and memory is enhanced...
April 6, 2007: Cell
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