T Svagusa, S Sikiric, M Milavic, A Sepac, S Seiwerth, D Milicic, H Gasparovic, B Biocina, I Rudez, Z Sutlic, S Manola, J Varvodic, M Udovicic, M Urlic, S Ivankovic, S Plestina, F Paic, A Kulic, P Bakovic, F Sedlic
BACKGROUND: Mitochondrial dysfunction is one of key factors causing heart failure. We performed a comprehensive analysis of expression of mitochondrial quality control (MQC) genes in heart failure. METHODS: Myocardial samples were obtained from patients with ischemic and dilated cardiomyopathy in a terminal stage of heart failure and donors without heart disease. Using quantitative real-time PCR, we analysed a total of 45 MQC genes belonging to mitochondrial biogenesis, fusion-fission balance, mitochondrial unfolded protein response (UPRmt), translocase of the inner membrane (TIM) and mitophagy...
July 4, 2023: European Journal of Clinical Investigation