keyword
MENU ▼
Read by QxMD icon Read
search

vaccine; immunization; immunisation

keyword
https://www.readbyqxmd.com/read/29132993/re-evaluating-the-effect-of-favipiravir-treatment-on-rabies-virus-infection
#1
Ashley C Banyard, Karen L Mansfield, Guanghui Wu, David Selden, Leigh Thorne, Colin Birch, Penelope Koraka, Albert D M E Osterhaus, Anthony R Fooks
There is no antiviral treatment available once clinical disease following rabies virus infection has initiated. Considered a neglected tropical disease, >60,000 human rabies deaths are estimated each year despite the availability of pre- and post-exposure prophylaxis for pre-immunisation or administration following a potential exposure before the onset of clinical disease. Such post-exposure treatments include administration of rabies immunoglobulin (RIG) and vaccination at a distant site to prime a humoral immune response...
November 10, 2017: Vaccine
https://www.readbyqxmd.com/read/29124321/vaccine-responses-in-newborns
#2
REVIEW
Anja Saso, Beate Kampmann
Immunisation of the newborn represents a key global strategy in overcoming morbidity and mortality due to infection in early life. Potential limitations, however, include poor immunogenicity, safety concerns and the development of tolerogenicity or hypo-responsiveness to either the same antigen and/or concomitant antigens administered at birth or in the subsequent months. Furthermore, the neonatal immunological milieu is polarised towards Th2-type immunity with dampening of Th1-type responses and impaired humoral immunity, resulting in qualitatively and quantitatively poorer antibody responses compared to older infants...
November 9, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29120017/review-of-maternal-immunisation-during-pregnancy-focus-on-pertussis-and-influenza
#3
Géraldine Blanchard-Rohner, Christiane Eberhardt
Seasonal influenza and pertussis infections are known to be significant causes of morbidity and mortality in neonates and infants worldwide. Influenza has also been associated with severe complications in pregnant women and after delivery. The most efficient and safe strategy to protect mothers and their offspring is maternal immunisation during pregnancy. The maternal antibodies thus acquired are transferred to the fetus as of the second trimester and confer passive immunity until the first infant immunisations...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29062078/design-and-evaluation-of-the-immunogenicity-and-efficacy-of-a-biomimetic-particulate-formulation-of-viral-antigens
#4
Victor Riitho, Adam A Walters, Satyanarayana Somavarapu, Benjamin Lamp, Till Rümenapf, Thomas Krey, Felix A Rey, Ernesto Oviedo-Orta, Graham R Stewart, Nicolas Locker, Falko Steinbach, Simon P Graham
Subunit viral vaccines are typically not as efficient as live attenuated or inactivated vaccines at inducing protective immune responses. This paper describes an alternative 'biomimetic' technology; whereby viral antigens were formulated around a polymeric shell in a rationally arranged fashion with a surface glycoprotein coated on to the surface and non-structural antigen and adjuvant encapsulated. We evaluated this model using BVDV E2 and NS3 proteins formulated in poly-(D, L-lactic-co-glycolic acid) (PLGA) nanoparticles adjuvanted with polyinosinic:polycytidylic acid (poly(I:C) as an adjuvant (Vaccine-NP)...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042916/the-proposal-of-paediatric-virology-and-its-perspectives-an-interview-with-professor-of-paediatrics-maria-theodoridou
#5
Ioannis N Mammas, Demetrios A Spandidos
Professor Maria Theodoridou, Emeritus Professor of Paediatrics at the University of Athens, is one of the few paediatricians in Greece, who have experienced almost all the infectious diseases of the second half of the 20th century and their severe consequences, prior to the widespread adoption of immunisations. A milestone during her career was the establishment of a specialised National Reference Unit for the care of paediatric patients with acquired immune deficiency syndrome (AIDS) at the 'Aghia Sophia' Children's Hospital in Athens, Greece...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29029940/antibody-dependent-phagocytosis-adp-responses-following-trivalent-inactivated-influenza-vaccination-of-younger-and-older-adults
#6
Fernanda Ana-Sosa-Batiz, Angus P R Johnston, P Mark Hogarth, Bruce D Wines, Ian Barr, Adam K Wheatley, Stephen J Kent
Globally the most commonly utilised immunisation against influenza is the trivalent inactivated influenza vaccine (TIV) derived from an A/H1N1, an A/H3N2 and aB type influenza virus. Vaccine effectiveness of TIV varies year to year, depending on how well antigenically matched the strains in the vaccine are compared to circulating strains [1,2]. Moreover, vaccine effectiveness can vary within certain subpopulations such as HIV-positive, young children and the elderly. Decreased vaccine effectiveness in the elderly is associated with impaired Ab production, as measured by standard hemagglutination inhibition (HAI) assays...
November 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29025851/investigating-bordetella-pertussis-colonisation-and-immunity-protocol-for-an-inpatient-controlled-human-infection-model
#7
Hans de Graaf, Diane Gbesemete, Andrew R Gorringe, Dimitri A Diavatopoulos, Kent E Kester, Saul N Faust, Robert C Read
INTRODUCTION: We summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally Bordetella pertussis is one of the leading causes of vaccine-preventable death. Many countries have replaced whole cell vaccines with acellular vaccines over the last 20 years during which pertussis appears to be resurgent in a number of countries in the developed world that boast high immunisation coverage. The acellular vaccine provides relatively short-lived immunity and, in contrast to whole cell vaccines, may be less effective against colonisation and subsequent transmission...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28982820/rubella-virus-infection-and-associated-factors-among-pregnant-women-attending-the-antenatal-care-clinics-of-public-hospitals-in-hawassa-city-southern-ethiopia-a-cross-sectional-study
#8
Biniam Tamirat, Siraj Hussen, Techalew Shimelis
OBJECTIVE: To assess the seroprevalence of recent/acute and past exposure to rubella virus infection and associated risk factors among pregnant women. DESIGN: A hospital-based cross-sectional study. SETTING: The study was conducted in two public hospitals in Hawassa City, Southern Ethiopia. PARTICIPANTS: A total of 422 pregnant women attending antenatal care clinics were selected using a systematic random sampling technique from March to June 2016...
October 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28979641/a-pilot-study-of-routine-immunization-data-quality-in-bunza-local-government-area-causes-and-possible-remedies
#9
Semeeh Akinwale Omoleke, Menberu Getachew Tadesse
INTRODUCTION: As a result of poor quality administrative data for routine immunisation (RI) in Nigeria, the real coverage of RI remains unknown, constituting a setback in curtailing vaccine preventable diseases (VPDs). Consequently, the purpose of this pilot study is to identify source(s) and evaluate the magnitude of poor data quality as well as propose recommendations to address the problem. METHODS: The authors conducted a cross-sectional study in which 5 out of the 22 health facilities providing routine immunization services in Bunza Local Government Area (LGA), Kebbi State, Nigeria, were selected for data quality assessment...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28978700/deletion-of-the-african-swine-fever-virus-gene-dp148r-does-not-reduce-virus-replication-in-culture-but-reduces-virus-virulence-in-pigs-and-induces-high-levels-of-protection-against-challenge
#10
Ana L Reis, Lynnette C Goatley, Tamara Jabbar, Pedro J Sanchez-Cordon, Christopher L Netherton, Dave G Chapman, Linda K Dixon
Many of the approximately 165 proteins encoded by African swine fever virus do not have significant similarity to known proteins and have not been studied experimentally. One such protein is DP148R. We showed that the DP148R gene is transcribed at early times post-infection. Deletion of this gene did not reduce virus replication in macrophages showing that is not essential for replication in these cells. However deleting this gene from a virulent isolate, Benin 97/1, dramatically reduced the virulence of the virus in vivo All pigs infected with the BeninΔDP148R virus survived infection showing only transient mild clinical signs soon after immunisation...
October 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28971282/investigating-the-candidacy-of-the-serotype-specific-rhamnan-polysaccharide-based-glycoconjugates-to-prevent-disease-caused-by-the-dental-pathogen-streptococcus-mutans
#11
Frank St Michael, Qingling Yang, Chantelle Cairns, Evgeny Vinogradov, Perry Fleming, Alexander C Hayes, Annie Aubry, Andrew D Cox
Dental caries remains a major health issue and the Gram-positive bacterium Streptococcus mutans is considered as the major pathogen causing caries. More recently, S. mutans has been recognised as a cause of endocarditis, ulcerative colitis and fatty acid liver disease along with the likelihood of increased cerebral hemorrhage following a stroke if S. mutans is present systemically. We initiated this study to examine the vaccine candidacy of the serotype specific polysaccharides elaborated by S. mutans. We have confirmed the carbohydrate structures for the serotype specific rhamnan containing polysaccharides from serotypes c, f and k...
October 2, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28917537/hbcag-produced-in-transgenic-tobacco-triggers-th1-and-th2-response-when-intramuscularly-delivered
#12
Marcin Pyrski, Anna Rugowska, Kamil Robert Wierzbiński, Anna Kasprzyk, Maria Bogusiewicz, Piotr Bociąg, Sławomir Samardakiewicz, Marcin Czyż, Maciej Kurpisz, Tomasz Pniewski
Hepatitis B core Antigen (HBcAg) assembled into Capsid-Like Particles (CLPs) is investigated as a therapeutic vaccine in treatment of chronic hepatitis B (CHB) and in diagnostic tests or as a carrier for various epitopes. While the expression of HBcAg has been thoroughly clarified in E. coli and yeast, it has also been investigated in other expression systems. Stably transformed tobacco expressed HBcAg at a level of 110-250µg/g fresh weight, therefore in view of its large leaf biomass it offers a production platform comparable with transient expression systems regarding the final yield of HBcAg...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28917316/humoral-and-cytokine-response-elicited-during-immunisation-with-recombinant-immune-mapped-protein-1-etimp-1-and-oocysts-of-eimeria-tenella
#13
Krishnendu Kundu, Rajat Garg, Saroj Kumar, Mrityunjay Mandal, Fiona M Tomley, Damer P Blake, Partha Sarathi Banerjee
Eimeria tenella, the causative agent of caecal coccidiosis, is a pathogenic gut dwelling protozoan which can cause severe morbidity and mortality in farmed chickens. Immune mapped protein-1 (IMP-1) has been identified as an anticoccidial vaccine candidate; in the present study allelic polymorphism was assessed across the IMP-1 coding sequence in E. tenella isolates from four countries and compared with the UK reference Houghton strain. Nucleotide diversity was low, limited to expansion/contraction of a CAG triplet repeat and five substitutions, three of which were non-synonymous...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28917313/field-evaluation-of-poultry-red-mite-dermanyssus-gallinae-native-and-recombinant-prototype-vaccines
#14
Kathryn Bartley, Frank Turnbull, Harry W Wright, John F Huntley, Javier Palarea-Albaladejo, Mintu Nath, Alasdair J Nisbet
Vaccination is a desirable emerging strategy to combat poultry red mite (PRM), Dermanyssus gallinae. We performed trials, in laying hens in a commercial-style cage facility, to test the vaccine efficacy of a native preparation of soluble mite extract (SME) and of a recombinant antigen cocktail vaccine containing bacterially-expressed versions of the immunogenic SME proteins Deg-SRP-1, Deg-VIT-1 and Deg-PUF-1. Hens (n=384 per group) were injected with either vaccine or adjuvant only (control group) at 12 and 17 weeks of age and then challenged with PRM 10days later...
September 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28915996/alternative-strategy-for-visceral-leishmaniosis-control-hisak70-salmonella-choleraesuis-pulsed-dendritic-cells
#15
Gustavo Domínguez-Bernal, Abel Martínez-Rodrigo, Alicia Mas, M Mar Blanco, José A Orden, Ricardo De La Fuente, Javier Carrión
Here, we describe a novel approach that exploits an attenuated mutant of Salmonella enterica serovar Choleraesuis as carrier to deliver a plasmid encoding protein HisAK70. Subsequently, dendritic cells (DCs) were pulsed with this vaccine vector. The aim of this study was to evaluate the effectiveness of the prepared HisAK70-S. Choleraesuis-pulsed DCs (HisAK70-SAL DCs) against visceral leishmaniosis (VL). In our ex vivo model of infection, the prepared formulations could decrease parasite growth by up to 80% by augmenting the production of IL-12p40 and by reducing arginase activity (ARG)...
October 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28899625/cost-effectiveness-of-hpv-vaccination-in-the-context-of-high-cervical-cancer-incidence-and-low-screening-coverage
#16
Triin Võrno, Katrin Lutsar, Anneli Uusküla, Lee Padrik, Terje Raud, Rainer Reile, Oliver Nahkur, Raul-Allan Kiivet
BACKGROUND: Estonia has high cervical cancer incidence and low screening coverage. We modelled the impact of population-based bivalent, quadrivalent or nonavalent HPV vaccination alongside cervical cancer screening. METHODS: A Markov cohort model of the natural history of HPV infection was used to assess the cost-effectiveness of vaccinating a cohort of 12-year-old girls with bivalent, quadrivalent or nonavalent vaccine in two doses in a national, school-based vaccination programme...
November 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28894312/-there-s-no-touching-in-pharmacy-training-pharmacists-for-australia-s-first-pharmacist-immunization-pilot
#17
Esther T L Lau, Michelle E Rochin, Megan DelDot, Beverley D Glass, Lisa M Nissen
BACKGROUND: Vaccination is a safe, efficient, and cost-effective means of preventing, controlling, and eradicating many life-threatening infections and diseases. Globally, the World Health Organization estimates that vaccination saves between 2 million and 3 million lives annually. However, low immunization rates are a significant public health concern. Individual factors, along with the vaccination process and system, have been reported as perceived barriers and challenges to immunization...
July 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28887219/novel-freeze-dried-dda-and-tpgs-liposomes-are-suitable-for-nasal-delivery-of-vaccine
#18
Helmy Yusuf, Ahlam A Ali, Natalie Orr, Michael M Tunney, Helen O McCarthy, Vicky L Kett
There is a pressing need for effective needle-free vaccines that are stable enough for use in the developing world and stockpiling. The inclusion of the cationic lipid DDA and the PEG-containing moiety TPGS into liposomes has the potential to improve mucosal delivery. The aim of this study was to develop stable lyophilized cationic liposomes based on these materials suitable for nasal antigen delivery. Liposomes containing DDA and TPGS were developed. Size and zeta potential measurements, ex vivo, CLSM cell penetration study and cell viability investigations were made...
November 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28883023/time-to-consider-a-targeted-hpv-vaccination-programme-for-male-military-recruits
#19
William M J Sharp, T Nadarzynski, N E Dufty
Human papillomaviruses (HPV) are the most common type of sexually transmitted infection in men but also related to high-risk cancers. This article considers the epidemiology of HPV in the male military population, the UK vaccination programme and the current UK Joint Committee on Vaccination and Immunisation recommendations. Military men may not benefit from HPV herd immunity and may have a different risk profile; vaccination may in turn reduce the operational burden of HPV-related disease within this population...
September 6, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28870202/an-assessment-of-healthcare-professionals-knowledge-about-and-attitude-towards-influenza-vaccination-in-freetown-sierra-leone-a-cross-sectional-study
#20
Peter Bai James, Inayat Ur Rehman, Abudulai Jawo Bah, Michael Lahai, Christine Princess Cole, Tahir Mehmood Khan
BACKGROUND: Vaccinating healthcare professionals against influenza is considered an effective infection control measure. However, there is a low uptake of influenza vaccine among healthcare professionals around the globe. Currently, it is unknown whether healthcare professionals in Sierra Leone are aware of, and have been vaccinated against influenza. Also, there is a paucity of research evidence on their level of knowledge and attitude toward influenza vaccination. This study assessed healthcare professionals' current influenza vaccine uptake rate, reasons for not getting vaccinated as well as their awareness, knowledge of, and attitude towards influenza vaccination in Freetown Sierra Leone...
September 5, 2017: BMC Public Health
keyword
keyword
110822
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"