keyword
https://read.qxmd.com/read/38533322/immunological-risk-factors-in-recurrent-pregnancy-loss-in-patients-with-hereditary-thrombophilia
#1
JOURNAL ARTICLE
Zlatko Kirovakov, Emiliana Konova, Nadezhda Hinkova, Stefani Markova, Plamen Penchev
BACKGROUND: Recurrent pregnancy loss (RPL) is a complicated reproductive disorder with underlying genetic and immunological causes. RPL may be influenced by hereditary thrombophilia, a class of blood clotting-related genetic abnormalities, via the vascular and immune systems. This study examines the immunological characteristics that hereditary thrombophilia patients have in common with RPL. METHODS: A prospective cohort study included 300 patients split into two groups: a control group without hereditary thrombophilia and a group with the condition...
March 2024: Curēus
https://read.qxmd.com/read/38528801/regulatory-role-of-mir-125a-expression-with-respect-to-its-target-genes-lifr-erbb2-and-stat3-in-the-pathogenesis-of-recurrent-pregnancy-losses
#2
JOURNAL ARTICLE
Usma Manzoor, Arshad A Pandith, Ina Amin, Saima Wani, Shahid M Baba, Umer M Wani, Sheikh Mansoor, Qurat Ul Aein, Iqra Anwar, Barjista Bahar, Aabid M Koul, Dheera Sanadhya, Abida Ahmad
OBJECTIVES: Studies have investigated miR-125a for its predictable role in recurrent pregnancy loss (RPL) cases to regulate many biological events required for the maintenance of pregnancy by regulating its confirmed target genes LIFR, ERBB2 and STAT3. METHODS: The present study included 40 cases of women with at least two RPLs in ≤20 weeks of gestation against 40 healthy multiparous women without a previous history of abortion. Expression analysis of ERBB2, LIFR, STAT3 and miR-125a was conducted by quantitative real-time PCR (qPCR)...
March 25, 2024: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/38526774/mechanisms-of-yap1-mediated-trophoblast-ferroptosis-in-recurrent-pregnancy-loss
#3
JOURNAL ARTICLE
Liping Chen, Fangfang Dai, Yanjie Huang, Jing Chen, Zhidian Li, Hua Liu, Yanxiang Cheng
PURPOSE: The purpose of our study is to investigate the function of YAP1 in the trophoblast ferroptosis and maternal-fetal interface communication of RPL. METHODS: We collected 25 villous tissues and detected the expression of YAP1. Cell counting kit-8 assay, scratch wound-healing assay, and Matrigel invasion assay were performed to observe the proliferation, migration, and invasion of HTR-8/SVneo and JAR cells. Subsequently, measured the levels of reactive oxygen species (ROS), malondialdehyde (MDA), reduced glutathione (GSH), SLC7A11, SOD2, and GPX4...
March 25, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38525519/outcomes-of-female-reproductive-performance-with-assisted-reproductive-techniques-after-recent-mild-to-moderate-covid-19-infections-an-observational-study
#4
JOURNAL ARTICLE
Ashraf Moini, Narges Najafpour, Ladan Kashani, Maryam Farid-Mojtahedi, Arezoo Maleki-Hajiagha, Afsaneh Tehranian, Rana Karimi
OBJECTIVE: The purpose of this study was to evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on clinical outcomes among high-risk patients. METHODS: This retrospective study involved 1,368 patients and the same number of cycles, including 520 cycles with PGT-A and 848 cycles without PGT-A. The study participants comprised women of advanced maternal age (AMA) and those affected by recurrent implantation failure (RIF), recurrent pregnancy loss (RPL), or severe male factor infertility (SMF)...
March 25, 2024: Clinical and Experimental Reproductive Medicine
https://read.qxmd.com/read/38520563/evaluation-of-changes-in-exhausted-t-lymphocytes-and-mirnas-expression-in-the-different-trimesters-of-pregnancy-in-pregnant-women
#5
JOURNAL ARTICLE
Ali Akbar Shekarchi, Leila Hosseini, Amin Kamrani, Iraj Alipourfard, Mohammad Sadegh Soltani-Zangbar, Morteza Akbari, Leila Roshangar, Leili Aghebati-Maleki, Forough Chakari-Khiavi, Aref Chakari-Khiavi, Kimia Motlagh Asghari, Shahla Danaii, Tannaz Pourlak, Javad Ahmadian Heris, Mehdi Yousefi
BACKGROUND: Throughout the three trimesters of a typical pregnancy, we looked at changes in the expression of miRNAs and exhausted T lymphocytes for this study. METHODS AND RESULTS: Fifty healthy subjects were included in this study. The frequency of exhausted T lymphocytes was measured in isolated PBMCs using flow cytometry. PD-1, TIM-3, and related miRNAs gene expression were assessed using qRT-PCR. The analyses revealed a significant decline in PD-1 and Tim-3 expression in PBMCs from RPL women (p = 0...
March 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38518419/hla-allele-frequency-of-hla-a-b-c-drb1-and-dqb1-in-indian-recurrent-implantation-failure-and-recurrent-pregnancy-loss-couples-a-retrospective-study
#6
JOURNAL ARTICLE
Sachin Shetty, Ashly Santhosh, Sree Parvathi S Pillai, Devika Gunasheela, Rajsekhar Nayak, Swathi Shetty
The maternal-fetal interaction has been hypothesized to involve the human leucocyte antigen (HLA). It has been suggested that excessive HLA antigen sharing between spouses is a mechanism causing maternal hyporesponsiveness to paternal antigens encountered during pregnancy and thus leading to a miscarriage. Participants in this retrospective study are RIF and RPL couples who visited Gunasheela Surgical and Maternity Hospital, Bangalore, India from November 2019 to September 2022. A total of 40 couples with RIF and 195 couples with RPL are included in the study...
March 3, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38516427/pregnancy-with-a-bicornuate-uterus-complicated-by-placenta-percreta-and-intraperitoneal-hemorrhage
#7
Reem Talal Almehzaa, Amala Sunder, Nayla Bushaqer
Uterine malformations significantly affect the reproduction process, and such anomalies can affect the progression and prognosis of a pregnancy. A bicornuate uterus is a rare congenital uterine anomaly that occurs due to a defect in the fusion of Müllerian ducts. It is associated with severe maternal and fetal complications, such as uterine rupture, vascular-related pathologies, preterm labor and birth, recurrent early or late loss of pregnancy, and fetal growth restriction. In such scenarios, close monitoring and ultrasound screening are needed to prevent obstetric complications...
February 2024: Curēus
https://read.qxmd.com/read/38514448/predicting-risk-of-subsequent-pregnancy-loss-among-women-with-recurrent-pregnancy-loss-an-immunological-factor-based-multivariable-model
#8
JOURNAL ARTICLE
Fangxiang Mu, Mei Wang, Xianghui Zeng, Fang Wang
PROBLEM: Studies on subsequent pregnancy loss prediction models specific for recurrent pregnancy loss (RPL) patients are very limited. This study aims to develop a risk predictive model based on the immunological parameters for the subsequent pregnancy loss risk in northwest Chinese RPL patients. METHOD OF STUDY: Totally of 357 RPL patients recruited from Lanzhou University Second Hospital were included in this retrospective study. Univariate analysis was performed on RPL patients with outcomes of live birth or pregnancy loss...
March 2024: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/38511530/immunological-parameters-of-maternal-peripheral-blood-as-predictors-of-future-pregnancy-outcomes-in-patients-with-unexplained-recurrent-pregnancy-loss
#9
JOURNAL ARTICLE
Yingrong Li, Irene X Y Wu, Xuan Wang, Jinlu Song, Quan Chen, Weiru Zhang
INTRODUCTION: Unexplained recurrent pregnancy loss (URPL), affecting approximately 1%-5% of women, exhibits a strong association with various maternal factors, particularly immune disorders. However, accurately predicting pregnancy outcomes based on the complex interactions and synergistic effects of various immune parameters without an automated algorithm remains challenging. MATERIAL AND METHODS: In this historical cohort study, we analyzed the medical records of URPL patients treated at Xiangya Hospital, Changsha, China, between January 2020 and October 2022...
March 21, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38506423/diagnostic-value-of-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratio-to-predict-recurrent-pregnancy-loss-and-abortion-a-systematic-review-and-meta-analysis
#10
REVIEW
Sedigheh Hantoushzadeh, Omid Kohandel Gargar, Kyana Jafarabady, Mohammad Moein Rezaei, Fatemeh Asadi, Nasim Eshraghi, Zahra Panahi, Saeedeh Shirdel, Masoumeh Mirzamoradi, Marjan Ghaemi
OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the diagnostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in women with a history of abortion (missed and threatened) and recurrent pregnancy loss (RPL) in comparison with healthy pregnancies. METHODS: Electronic databases including MEDLINE, Scopus, Web of Science, Embase, and Cochrane Library were searched for NLR and PLR in women who experienced early pregnancy loss up to January 1, 2023 with a combination of proper keywords...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38484879/common-mental-disorders-and-risk-of-spontaneous-abortion-or-recurrent-spontaneous-abortion-a-two-sample-mendelian-randomization-study
#11
JOURNAL ARTICLE
Yunan He, Lu Wang, Ruonan Tang, Hongbin Jin, Bangshan Liu, Shuqiang Chen, Hui Mu, Xiaohong Wang
BACKGROUND: The direct causal relationships between common mental disorders (anxiety disorders, broad depression, major depressive disorder (MDD), bipolar disorder, and insomnia) and miscarriage or recurrent spontaneous abortion (RSA) are unclear. Therefore, this study aimed to explore these, using Mendelian randomization. METHODS: Genome-wide association studies (GWAS) meta-analyses with the largest sample size possible and selected independent single individuals of European ancestry were selected...
March 12, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38482257/chromosomal-abnormalities-in-early-pregnancy-losses-a-study-of-900-samples
#12
JOURNAL ARTICLE
Gj Bozhinovski, M Terzikj, K Kubelka-Sabit, Dz Jasar, S Lazarevski, V Livrinova, D Plaseska-Karanfilska
Chromosomal abnormalities are the most common causes of early pregnancy losses (EPLs). In this study, we aimed to evaluate the incidence and spectrum of chromosomal abnormalities in EPLs and correlate them with different clinical characteristics. We performed Quantitative Fluorescent PCR (QF-PCR), followed by subtelomeric Multiplex Ligation Probe Amplification (MLPA) analysis to detect chromosomal abnormalities in 900 products of conceptions (POCs) from EPLs collected over a period of 10 years. Chromosomal abnormalities were present in 56...
December 2023: Balkan Journal of Medical Genetics: BJMG
https://read.qxmd.com/read/38481031/progestogens-in-women-with-threatened-miscarriage-or-recurrent-miscarriage-a-meta-analysis
#13
REVIEW
Yunli Zhao, Rohan D'Souza, Ya Gao, Qiukui Hao, Lucas Kallas-Silva, Jeremy P Steen, Gordon Guyatt
INTRODUCTION: Clinical practice guidelines provide inconsistent recommendations regarding progestogen supplementation for threatened and recurrent miscarriage. We conducted a systematic review and meta-analysis to assess the effectiveness and safety of progestogens for these patients. MATERIAL AND METHODS: We searched Medline, Embase, and Cochrane Central Registry of Controlled Trials up to October 6, 2023 for randomized control trials (RCTs) comparing progestogen supplementation to placebo or no treatment for pregnant women with threatened or recurrent miscarriage...
March 13, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38469100/importance-and-application-of-wes-in-fetal-genetic-diagnostics-identification-of-novel-aspm-mutation-in-a-fetus-with-microcephaly
#14
Renata Szalai, Agnes Till, Attila Gyenesei, Judit Bene, Kinga Hadzsiev
BACKGROUND: Prenatal whole exome sequencing (WES) approaches can provide genetic diagnosis with rapid turnaround time and high diagnostic rate when conventional tests are negative. Here we report a family with multiple pregnancy loss and with repeated occurrence of fetal microcephaly. METHODS AND RESULTS: Because of positive family history and recurrent structural abnormality during the pregnancies that may lead postnatal neurodevelopmental consequences, WES analysis was indicated...
March 2024: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/38467350/bibliometric-analysis-of-the-global-trends-in-immune-related-recurrent-pregnancy-loss-research-over-the-last-two-decades
#15
JOURNAL ARTICLE
Jing-Wei Li, Honglin Xv, Ren-Tao Wan
PROBLEM: A comprehensive analysis was conducted to explore the scientific output on immune-related recurrent pregnancy loss (RPL) and its key aspects. Despite the lack of clear explanations for most RPL cases, immune factors were found to play a significant role. METHOD OF STUDY: The study utilized a bibliometric approach, searching the Web of Science Core Collection database for relevant literature published between 2004 and 2023. RESULTS: The collected dataset consisted of 2228 articles and reviews, revealing a consistent increase in publications and citations over the past two decades...
March 11, 2024: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/38447289/sars-cov-2-infection-in-pregnant-patients-on-tnf%C3%AE-inhibitor-real-life-data-with-a-review-of-literature
#16
JOURNAL ARTICLE
Yiqi Yu, Jiaying Pan, Yiqi Zhao, Xiaoyan Guo, Wenting Yu, Feifei Zhou, Jing Shu, Qiongxiao Huang
Tumor necrosis factor alpha (TNFα) is involved in the occurrence of negative pregnancy outcomes. The study aimed to evaluate the safety and efficacy of the immunosuppressive TNFα inhibitors (TNFαi) in the treatment of patients with a history of recurrent reproductive failure in the context of COVID-19 pandemics. We reviewed 85 patients who received TNFαi (certolizumab pegol) during Mainland China's first wave of COVID-19 pandemic, from 21st Nov 2022-11 th Jan 2023. We also collected corresponding data from 130 pregnant patients who never used TNFαi for comparison...
February 21, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38447288/angiogenic-factors-and-the-lectin-pathway-of-complement-in-women-with-secondary-recurrent-pregnancy-loss
#17
JOURNAL ARTICLE
M C Krog, E M Flachs, A M Kolte, W de Jager, L Meyaard, O B Christiansen, R Steffensen, K Vomstein, P Garred, H S Nielsen
The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of Mannose-binding-lectin (MBL), a pattern recognition molecule (PRM) of the lectin pathway, have been found in women with RPL. We propose that pregnancy loss is connected to defective angiogenesis with reperfusion damage in the placenta and decreased levels of PRM in the lectin pathway in women with RPL...
February 27, 2024: Journal of Reproductive Immunology
https://read.qxmd.com/read/38444066/skin-erythematous-migrant-lesions-consistent-with-histologically-confirmed-dermal-arteriolar-thrombosis-connected-to-aps
#18
JOURNAL ARTICLE
Silvia Suardi, Jacopo Croce, Chiara Colato, Paola Chiara Rizzo, Simonetta Friso, Francesca Pizzolo
Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, anti Beta2-glycoprotein) known to cause venous and arterial thrombosis and recurrent pregnancy loss. Skin disorder is a frequent finding usually due to vascular thrombosis involving the dermal layer and can be either localized or widespread causing necrosis and ulceration of the skin, without histological evidence of vasculitis. We present a case of a woman with APS with both arterial and venous thrombotic involvement associated with an atypical dermatological manifestation histologically consistent with a pauci-inflammatory intermediate-deep dermal arteriolar platelet-mediated thrombosis that appeared despite anticoagulation with warfarin and responding to the addition of antiplatelet therapy...
March 5, 2024: Lupus
https://read.qxmd.com/read/38443929/detection-of-human-platelets-antigen-polymorphism-hpa-1-and-hpa-3-and-human-factor-xiii-mutation-in-sudanese-women-with-recurrent-pregnancy-loss
#19
JOURNAL ARTICLE
Asaad Ma Babker, Huda Ahamed Fadlalmula, Amanda Gamal G Elggourish, Hanan Khalid Fadul Ahmed, Shima Yousri Masoud Awad, Salaheldein G Elzaki, Rania Saad Suliman, Abdulkarim S Bin Shaya, Abdulaziz Alfahed, Nahed S Alharthi, Ahmed M Hjazi, Nora Y Hakami, Mohammed Ageeli Hakami, Alhomidi Almotiri, Hisham Ali Waggiallah
BACKGROUND: Recurrent pregnancy Loss (RPL) is common problem affecting many couples. A certain genetic variants link to increase the danger of this condition particularly HPA-1, HPA-3 and Human Factor XIII Val34Leu Mutation. The present study aims to find an association between RPL and the Factor XIII Val34Leu polymorphism, as well as HPA-1 and HPA-3 in Sudanese women with RPL. METHODS: This case-control study conducted between June 2022 and December 2022 included 216 women, with 103 cases having minimum three abortions in the past, and 113 healthy controls with at least two full-term births and no abortion history...
March 5, 2024: BMC Research Notes
https://read.qxmd.com/read/38440964/evaluation-of-endometrial-receptivity-in-recurrent-pregnancy-loss-and-recurrent-implantation-failure
#20
JOURNAL ARTICLE
Sultan Canan, Mehmet Arda İnan, Ahmet Erdem, Erhan Demirdağ, Mualla İlknur Gündüz, Özlem Erdem, Mehmet Erdem
OBJECTIVE: The cause of implantation defects in patients with recurrent implantation failure (RIF) and recurrent pregnancy loss (RPL) has not been clearly established. We aimed to evaluate the immunohistochemical changes in HOXA-11, β1 integrin, focal adhesion kinase (FAK), cluster of differentiation 44 (CD44), and extracellular matrix protein 1 (ECM1) molecules during the receptive endometrial period in patients with RIF and RPL. MATERIALS AND METHODS: This study was retrospectively conducted at a university hospital...
March 4, 2024: Turkish Journal of Obstetrics and Gynecology
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