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Salvatore Scaramuzzino, Claudio Carallo, Giampaolo Pileggi, Agostino Gnasso, Maria Francesca Spadea
The purpose of this work is to present and validate a novel approach for ultra-sound-based speckle tracking to measure the carotid artery longitudinal displacement, and to assess the apparent sliding between of Intima-Media Complex (IMC) and Adventitia (Ad) layers. This method utilizes feature detectors and descriptors to localize and track keypoints for local motion quantification. The procedure was tested and validated on an in silico dataset and on 18 heathy volunteers and 16 patients. Accuracy measured on in silico data gave a mean ± standard deviation of 23 ± 15 and 19 ± 18 μm for IMC and Ad respectively, and thus smaller than the pixel size (0...
March 31, 2017: Annals of Biomedical Engineering
Enrico Mugnaioli, Mauro Gemmi, Marco Merlini, Michele Gregorkiewitz
(Nax□1 - x)5[MnO2]13 has been synthesized with x = 0.80 (4), corresponding to Na0.31[MnO2]. This well known material is usually cited as Na0.4[MnO2] and is believed to have a romanèchite-like framework. Here, its true structure is determined, ab initio, by single-crystal electron diffraction tomography (EDT) and refined both by EDT data applying dynamical scattering theory and by the Rietveld method based on synchrotron powder diffraction data (χ(2) = 0.690, Rwp = 0.051, Rp = 0.037, RF2 = 0.035). The unit cell is monoclinic C2/m, a = 22...
December 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
Rashad Al-Salahi, Hatem A Abuelizz, Mahasin Wadi, Rabab A El Dib, Mshari A Alotaibi, Mohamed Marzouk
BACKGROUND: The present study was carried out to evaluate the antimicrobial activity of a synthesized 2-methylthio-benzo[g][1,2,4]triazolo[1,5- a]quinazoline series. The compounds (1-21) were tested against a variety of Gram-positive bacterial species including Bacillus subtilis (RCMB 01001 69-3), Enterococcus faecalis (RCMB 0100154-2), Staphylococcus aureus (RCMB 0100183-9), Staphylococcus epidermidis (RCMB 0100183-9) and Streptococcus pyogenes (RCMB 0100172-5). In addition, Gram-negative bacteria were also tested including Pseudomonas aeruginosa (RCMB 0100243-5), Escherichia coli (RCMB 010052-6), Proteus mirabilis (RCMB 01002 54-2), Klebsiella oxytoca (RCMB 01002 83-4) and Enterobacter cloacae (RCMB 01002 64-5)...
2016: Medicinal Chemistry
Zerrin Sezgin Bayindir, Arzu Beşikci Be, Nilüfer Yüksel
BACKGROUND/AIM: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. MATERIALS AND METHODS: Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for paclitaxel determination in rat plasma and tissues. RESULTS: The area under the curve value of the niosome-recipient group (3...
2015: Turkish Journal of Medical Sciences
Diane E Milenic, Alfredo A Molinolo, María S Solivella, Eileen Banaga, Julien Torgue, Sarah Besnainou, Martin W Brechbiel, Kwamena E Baidoo
Faced with the novelty of a 212Pb-labeled monoclonal antibody (mAb) for clinical translation, concerns were expressed by the Food and Drug Administration (FDA) regarding 212Pb prematurely released from the mAb-chelate conjugate. The objective of this study was to simulate the worst case scenario of such a failure. Groups of Balb/c mice (n = 9-20) were administered 212Pb by intraperitoneal (0.0925-1.85 MBq) or intravenous (0.0925-1.11 MBq) injection and then euthanized at 7 or 90 days to assess acute or chronic effects...
July 24, 2015: Pharmaceuticals
Rajini Mudhasani, Krishna P Kota, Cary Retterer, Julie P Tran, Chris A Whitehouse, Sina Bavari
High content image-based screening was developed as an approach to test a protease inhibitor small molecule library for antiviral activity against Rift Valley fever virus (RVFV) and to determine their mechanism of action. RVFV is the causative agent of severe disease of humans and animals throughout Africa and the Arabian Peninsula. Of the 849 compounds screened, 34 compounds exhibited ≥ 50% inhibition against RVFV. All of the hit compounds could be classified into 4 distinct groups based on their unique chemical backbone...
August 2014: PLoS Neglected Tropical Diseases
Catherine Dutreix, Sebastien Lorenzo, Yanfeng Wang
PURPOSE: Midostaurin, a multitargeted tyrosine kinase inhibitor, is primarily metabolized by CYP3A4. This midostaurin drug-drug interaction study assessed the dynamic response and clinical usefulness of urinary 6β-hydroxycortisol to cortisol ratio (6βCR) and plasma 4β-hydroxycholesterol (4βHC) for monitoring CYP3A4 activity in the presence or absence of rifampicin, a strong CYP3A4 inducer. METHODS: Forty healthy adults were randomized into groups for either placebo or treatment with rifampicin 600 mg QD for 14 days...
August 2014: European Journal of Clinical Pharmacology
André Luiz Ventura Savio, Glenda Nicioli da Silva, Elaine Aparecida de Camargo, Daisy Maria Fávero Salvadori
Allyl isothiocyanate (AITC) is present in plants of the cruciferous family and is abundant in mustard seed. Due to its high bioavailability in urine after ingestion, AITC has been considered a promising antineoplastic agent against bladder cancer. Because TP53 mutations are the most common alterations in bladder cancer cells and are frequently detected in in situ carcinomas, in this study, we investigated whether the AITC effects in bladder cancer cells are dependent on the TP53 status. Two bladder transitional carcinoma cell lines were used: RT4, with wild-type TP53; and T24, mutated TP53 gene...
April 2014: Mutation Research
Alex George, Rupraj Dey, Vikas Bhuria, Shouvik Banerjee, Sivakumar Ethirajan, Ashok Siluvaimuthu, Radha Saraswathy
Head and neck cancers (HNC) are extremely complex disease types and it is likely that chromosomal instability is involved in the genetic mechanisms of its genesis. However, there is little information regarding the background levels of chromosome instability in these patients. In this pilot study, we examined spontaneous chromosome instability in short-term lymphocyte cultures (72 hours) from 72 study subjects - 36 newly diagnosed HNC squamous cell carcinoma patients and 36 healthy ethnic controls. We estimated chromosome instability (CIN) using chromosomal aberration (CA) analysis and nuclear level anomalies using the Cytokinesis Block Micronucleus Cytome Assay (CBMN Cyt Assay)...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Andrea Tinelli, Antonio Malvasi, Ospan A Mynbaev, Daniel Alberto Tsin, Fausto Davila, Guillermo Dominguez, Emanuele Perrone, Farr R Nezhat
BACKGROUND: Recently, we have shown advantages of a direct optical entry (DOE) using a bladeless trocar in comparison with the open Hasson technique (OHT) in older reproductive-age women with previous operations, as well as in comparison with Veress needle entry in reproductive-age and postmenopausal women. OBJECTIVES: A prospective multicenter randomized study to determine whether the DOE is feasible for establishing safe and rapid entry into the abdomen in comparison with those of the OHT in reproductive-age obese women...
October 2013: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Dong Woo Lee, Kang Min Ok
Three new gallium selenites, Rb3HGa2(OH)2(SeO3)4, Rb3Ga5(SeO3)8(HSeO3)2·0.5H2O, and RbGa(SeO3)2·H2O, have been synthesized by hydrothermal reactions using Rb2CO3, Ga(NO3)3·xH2O, and SeO2 as reagents. Rb3HGa2(OH)2(SeO3)4 consists of unidimensional corner-linked chains of GaO4(OH)2 that are connected by a SeO3 group, whereas Rb3Ga5(SeO3)8(HSeO3)2·0.5H2O and RbGa(SeO3)2·H2O exhibit three-dimensional frameworks consisting of three, mutually perpendicular, eight-membered rings (8-MRs). In all three reported materials, Se(4+) is in an asymmetric coordination environment attributable to the stereoactive lone pair...
September 3, 2013: Inorganic Chemistry
Betty Korljan-Babić, Sanja Barsić-Ostojić, Zeljko Metelko, Nikica Car, Manja Prasek, Veselin Skrabić, Slaven Kokić
The aim was to assess glycemia regulation in a blind diabetic patient after getting a guide dog. Glycosylated hemoglobin (HbA1c) results of a blind patient before and after getting the guide dog were retrospectively collected. The paired t-test results yielded a two-tailed P value of 0.0925, a difference considered not statistically significant; the 95% confidence interval of this difference varied from -0.2494 to 1.889. An improvement of glycemia regulation was observed with the guide dog compared to previous glycemia regulation, however, the difference was not statistically significant...
June 2011: Acta Clinica Croatica
Ali F Aburahma, John E Campbell, Albeir Y Mousa, Stephen M Hass, Patrick A Stone, Akhilesh Jain, Aravinda Nanjundappa, L Scott Dean, Tammi Keiffer, Joseph Habib
BACKGROUND: Endovascular aneurysm repair (EVAR) is not generally recommended for patients with hostile neck anatomy. This study analyzed the clinical implications of various clinical features of proximal aortic neck anatomy. METHODS: Prospectively collected data from 258 EVAR patients using modular devices were analyzed. Patients were classified as having favorable neck anatomy (FNA) or hostile neck anatomy (HNA). HNA was defined as any or all of length of <10 mm, angle of >60°, diameter of >28 mm, ≥50% circumferential thrombus, ≥50% calcified neck, and reverse taper...
July 2011: Journal of Vascular Surgery
Haiyan Yao, Yuan Ren, Xiuqiong Deng, Chaohai Wei
Phenols and N-heterocyclic compounds are found to co-exist in actual wastewater, especially in petrochemical and coking wastewater. Lysinibacillus cresolivorans, a bacterium capable of phenol-biodegradation was used to study the substrate interactions of m-cresol and pyridine as single and dual substrates. The cell growth and substrate biodegradation kinetics were also investigated with initial m-cresol concentrations varying from 0 to 1200 mg/L and pyridine concentrations varying from 0 to 150 mg/L. The single substrate kinetics was well described by the Haldane kinetic models...
February 28, 2011: Journal of Hazardous Materials
Lucile Vincent, Léonard Féasson, Samuel Oyono-Enguéllé, Viviane Banimbek, Géraldine Monchanin, Macias Dohbobga, Dieudonné Wouassi, Cyril Martin, David Gozal, André Geyssant, Patrice Thiriet, Christian Denis, Laurent Messonnier
Previous studies have shown that subjects with sickle cell trait (SCT), alpha-thalassemia (alpha-t), and the dual hemoglobinopathy (SCT/alpha-t) manifest subtle, albeit significant, differences during exercise. To better understand such differences, we assessed skeletal muscle histomorphological and energetic characteristics in 10 control HbAA subjects (C), 5 subjects with alpha-t (alpha-t), 6 SCT carriers (SCT) and 9 SCT carriers with alpha-t (SCT/alpha-t). Subjects underwent a muscle biopsy and also performed an incremental maximal exercise and a time to exhaustion test...
September 2010: Journal of Applied Physiology
Melda Sisecioglu, Murat Cankaya, Hasan Ozdemir
OBJECTIVE: The present paper investigates the in vitro effect of L-ascorbic acid (vitamin C), menadione sodium bisulfate (vitamin K3), and folic acid on purified lactoperoxidase (LPO). METHODS: This enzyme was purified from bovine milk by Amberlite CG 50 resin, CM Sephadex C-50 ion-exchange chromatography, and Sephadex G-100 gel filtration chromatography. RESULTS: Rz (A412/A280) value for the purified LPO was found to be 0.8. Lactoperoxidase was purified 20...
May 2009: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
John N van den Anker, Pavla Pokorna, Martina Kinzig-Schippers, Jirina Martinkova, Ronald de Groot, G L Drusano, Fritz Sorgel
We studied meropenem in 23 pre-term (gestational age, 29 to 36 weeks) and 15 full-term (gestational age, 37 to 42 weeks) neonates. Meropenem doses of 10, 20, and 40 mg/kg were administered as single doses (30-min intravenous infusion) on a random basis. Blood was obtained for determining the meropenem concentration nine times. Each child required other antimicrobials for proven/suspected bacterial infections. Samples were assayed by high-performance liquid chromatography analysis. Population pharmacokinetic parameter values were obtained by employing the BigNPAG program...
September 2009: Antimicrobial Agents and Chemotherapy
De-li Wu, Hong-wu Wang, Jin-hong Fan, Lu-ming Ma
Various bimetallic reductants of Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe were prepared by plating Cu, Ag, Pd and Ni on the surface of Fe0. Reductive dechlorination of toxic pollutants of CCl4 in water with Fe0 and amended Fe0 by batch experiments was investigated. Results show that CCl4 in water can be rapidly dechlorinated by above five catalytic reductants, and the presence of Cu, Ag, Pd can enhance the dechlorination rate dramatically. The reaction of CCl4 with various reductants was followed the pseudo first order kinetics, and the dechlorination rate constant of CCl4 in water by Fe0, Cu/Fe, Ag/Fe, Pd/Fe and Ni/Fe was 0...
December 2008: Huan Jing Ke Xue= Huanjing Kexue
P Ballanti, G Coen, G M Braga Marcazzan, S Mazzaferro, E Cereda, E Bonucci
It is well-known that bone volume decreases with age both in normal subjects and particularly in osteoporotic patients. It is not well demonstrated, however, whether bone loss is associated with changes in the composition of bone tissue and especially with altered concentration of mineral elements. To verify whether calcium density changes with aging, autoptic specimens, of iliac crest trabecular bone from 20 normal subjects between 21 and 66 years, 10 males and 10 females were analyzed by using a new method which allows the measurement of calcium density in a non-destructive way, on entire histologic sections of the bone...
1992: Archives of Gerontology and Geriatrics
Bui Thi Nhung, Nguyen Cong Khan, Le Thi Hop, Nguyen Thi Lam, Nguyen Le Bao Khanh, Do Thi Kim Lien, Masayo Nakamori, Vu Thi Thu Hien, Afework Kassu, Shigeru Yamamoto
BACKGROUND/AIMS: To evaluate the FAO/WHO/UNU equations for predicting resting metabolic rate (RMR) in elderly Vietnamese. METHODS: A cross-sectional study involving healthy and elderly subjects was carried out at the Basic Nutrition Department, National Institute of Nutrition, Vietnam. A total of 75 subjects who had a normal body mass index (BMI) were divided into two groups according to sex. The RMR was measured by indirect calorimetry and anthropometric indices were recorded...
2007: Annals of Nutrition & Metabolism
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