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https://www.readbyqxmd.com/read/29315154/characteristics-and-comorbidities-of-inpatients-without-celiac-disease-on-a-gluten-free-diet
#1
John W Blackett, Meghana Shamsunder, Norelle R Reilly, Peter H R Green, Benjamin Lebwohl
OBJECTIVES: Despite the increasing popularity of gluten-free diet (GFD), the demographic characteristics and medical features of patients without celiac disease on this diet have not been extensively investigated.We aimed to characterize the medical conditions and demographic backgrounds of hospitalized patients without celiac disease who adhere to a GFD, to further understand their reasons for gluten avoidance. MATERIALS AND METHODS: We performed an observational cohort study on all inpatients at Columbia University Medical Center on a GFD in 2011-2016, excluding those with celiac disease, compared with age-matched and sex-matched inpatients on a regular diet...
January 8, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29306458/impact-of-subclinical-hypothyroidism-on-clinical-outcomes-following-percutaneous-coronary-intervention
#2
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
BACKGROUND: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear. METHODS: We performed a prospective cohort study. SCH was defined as a thyroid-stimulating hormone (TSH) level ≥4.5mIU/l and a normal level of free thyroxine (FT4). A composite event was defined as the combination of cardiac death, non-fatal myocardial infarction (MI) and repeat revascularization...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29301831/efficacy-safety-and-pharmacokinetics-of-axitinib-in-nasopharyngeal-carcinoma-a-preclinical-and-phase-2-correlative-study
#3
Edwin P Hui, Brigette B Y Ma, Herbert Loong, Frankie Mo, Leung Li, Ann D King, Ki Wang, Anil T Ahuja, Charles Ml Chan, Connie Wc Hui, Chi-Hang Wong, Anthony Tc Chan
PURPOSE: We hypothesized that axitinib is active with improved safety profile in nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN: We evaluated axitinib in preclinical models of NPC, and studied its efficacy in a phase 2 clinical trial in recurrent or metastatic NPC patients who progressed after at least one line of prior platinum-based chemotherapy. We excluded patients with local recurrence or vascular invasion. Axitinib was started at 5 mg twice-daily in continuous 4-weeks cycles...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29279710/stroke-in-a-young-man-secondary-to-paroxysmal-atrial-fibrillation-and-thyrotoxicosis-a-case-report
#4
Rodrigo Bazan, Thiago Dias Fernandes, Gláucia Maria Ferreira da Silva Mazeto, Mariângela Esther Alencar Marques, Gabriel Pereira Braga, Gustavo José Luvizutto, Silméia Garcia Zanati Bazan
We report a case of a male patient with stroke caused by atrial fibrillation (AF) due to thyrotoxicosis. At hospital admission, he presented hypertension and AF. Magnetic resonance imaging confirmed a right-side ischemic area. The thyrotoxicosis was confirmed by thyroid function and thyroid scintigraphy that showed goiter with diffuse hypercaptation. The patient was treated with tapazole and total thyroidectomy, and pathological findings suggested Graves' disease. Hyperthyroidism is associated with increased supraventricular ectopic activity in patients with a normal heart, and may be an important causal link between hyperthyroidism and AF...
September 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/29275846/factors-associated-with-poor-active-anterior-elevation-after-reverse-total-shoulder-arthroplasty
#5
Yoon Sang Jeon, Yong Girl Rhee
BACKGROUND: Although reverse total shoulder arthroplasty (RTSA) has been shown to reduce pain and to improve function in most patients, some still suffer from functional limitations. This study aimed to investigate the incidence of poor motion recovery after RTSA and to identify factors that may cause poor outcomes. METHODS: Seventy-six patients who underwent primary RTSA with a reverse-type Aequalis prosthesis (Tornier, Montbonnot, France) were allocated to a satisfactory or unsatisfactory group on the basis of their postoperative active anterior elevation...
December 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29261514/association-of-prothrombotic-adipokine-plasminogen-activator-inhibitor-1-with-tsh-in-metabolic-syndrome-a-case-control-study
#6
Ashok Kumar Ahirwar, Archana Singh, Anju Jain, Kirti Kaim, Shilpa Bhardwaj, Surajeet Kumar Patra, Binita Goswami, M K Bhatnagar, Jayashree Bhattacharjee
Background Metabolic syndrome (MetS) involves a cluster of cardiovascular risk factors, including abnormal lipids, insulin resistance and hypertension. The aim of the present study is to investigate associations between thyroid profile and the pro-thrombotic mediator, plasminogen activator inhibitor-1 (PAI-1), in MetS and identify associated biochemical markers. Materials and methods The present study was a case control study and consisted of 50 diagnosed cases of MetS and 50 healthy volunteers as controls...
December 20, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29250690/difficulty-in-positive-diagnosis-of-ascites-and-in-differential-diagnosis-of-a-pulmonary-tumor
#7
Mircea Cătălin ForŢofoiu, Dragoş Marian Popescu, Vlad Pădureanu, Aurelian Constantin Dobrinescu, Adrian Gabriel Dobrinescu, Adrian Mită, Maria Camelia Foarfă, Violeta Serenada Bălă, Anca Emanuela Muşetescu, Nina Ionovici, Maria ForŢofoiu
Ascites is the most frequent complication of cirrhosis and occurs only when the portal hypertension has already installed but ascites is caused by neoplasms, heart failure, tuberculosis, pancreatic illnesses, as well as other kind of affections. We describe the case of a 67-year-old patient, a retired person, without significant personal or familial history, nonsmoker, infrequent alcohol and coffee consumer with following chief complaints at onset: loss of appetite, weight loss, serious physical asthenia, delayed intestinal transit, diffuse abdominal pain and increase of abdominal circumference...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29238484/pattern-and-factors-associated-with-cardiovascular-diseases-among-patients-attending-the-cardiac-center-in-arar-city-northern-saudi-arabia
#8
Fatimah Fahad Altaleb, Othman Mashfi Alshammari, Hala Mohammed Alanazi, Dina Anwar Aljaber, Arwa Bader Alanazi, Nagah Mohamed Abo El-Fetoh, Nesreen Ali Mohammed, Hadil Anwar Aljaber
Background: Cardiovascular diseases (CVD) are among the main causes of premature death and hospital admission worldwide, constituting a great economic burden on health care systems. Additionally, thyroid diseases may exert a deleterious effect on the outcomes of CVD patients. Aim: This study was conducted to identify the pattern and factors associated with CVD distribution and the relation with thyroid dysfunction in the study population. Methods: This cross sectional study was conducted on 181 participants in the cardiac center in Arar, Kingdom of Saudi Arabia (KSA), from September 2016 to March 2017...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29214084/coexistence-of-primary-hyperaldosteronism-and-graves-disease-a-rare-combination-of-endocrine-disorders-is-it-beyond-a-coincidence-a-case-report-and-review-of-the-literature
#9
S S C Gunatilake, U Bulugahapitiya
Background: Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays a role in immunomodulation/development of autoimmunity. Recent researches also suggest significant thyroid dysfunction among patients with hyperaldosteronism, but exact causal relationship is not established. Autoimmune hyperthyroidism (Graves' disease) and primary hyperaldosteronism rarely coexist but underlying mechanisms associating the two are still unclear...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29183364/unusual-presentations-of-functional-parathyroid-cysts-a-case-series-and-review-of-the-literature
#10
Youssef El-Housseini, Martin Hübner, Ariane Boubaker, Jan Bruegger, Maurice Matter, Olivier Bonny
BACKGROUND: Cysts of parathyroid origin are sometimes encountered and can easily be mistaken as thyroidal cysts. Functional parathyroid cysts, with symptoms and signs of hyperparathyroidism, are rare and may be a diagnostic challenge to clinicians. We report here on three cases of functional parathyroid cysts that illustrate diagnosis difficulties related to unusual clinical presentations in three Caucasian women, including negative parathyroid scintigraphy. CASE PRESENTATIONS: Patient 1, an 87-year-old Caucasian woman presented with confusion and dysphagia...
November 29, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29167277/aging-related-disease-risks-among-young-thyroid-cancer-survivors
#11
Brenna E Blackburn, Patricia A Ganz, Kerry Rowe, John Snyder, Yuan Wan, Vikrant Deshmukh, Michael Newman, Alison Fraser, Ken Smith, Kimberly Herget, Jaewhan Kim, Anne C Kirchhoff, Christina Porucznik, Heidi Hanson, Marcus Monroe, Mia Hashibe
Background: Thyroid cancer is the most rapidly increasing cancer in the United States, affects a young population, has high survival, and is one of the most common cancers in people under age 40. The aim of this study was to examine the risks of aging-related diseases in a statewide sample of thyroid cancer survivors who were diagnosed <40 years compared with those diagnosed ≥40 and a cancer-free sample.Methods: Thyroid cancer survivors diagnosed 1997 to 2012 were matched to up to 5 cancer-free individuals on birth year, sex, birth state, using the statewide Utah Population Database...
November 22, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29166819/pregnancy-outcomes-among-women-with-asthma
#12
Haitham Baghlaf, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: The purpose of this study is to examine the association between maternal asthma and pregnancy, delivery and neonatal outcomes. MATERIALS AND METHODS: We carried out a retrospective cohort study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database from 2003 to 2011. Among women who delivered during this time period, we compared pregnancy, delivery, and neonatal outcomes in asthmatics versus non-asthmatics. Multivariate logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals...
November 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29113155/poems-syndrome-presentation-with-progressive-weakness-in-upper-and-lower-limbs-a-case-report
#13
Chuang-Jie Cao, Cheng-Yun Dou, Ke-Hua Zhou, Jin-Bo Liu, Hong Lai
Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typicallyλ-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29107455/type-2-diabetes-mellitus-and-risk-of-open-angle-glaucoma-development-in-koreans-an-11-year-nationwide-propensity-score-matched-study
#14
Y Jung, K Han, H-Y L Park, C K Park
PURPOSE: To evaluate the risk of primary open-angle glaucoma (POAG) development in type 2 diabetes mellitus (T2DM) patients. METHODS: In this 11-year longitudinal study based on the Korean National Health Insurance research database, the data collected comprised 1,025,340 (2.2%) participants who were randomly selected from 46,605,433 Korean residents in 2002. The database was analyzed to identify participants with an initial diagnosis of T2DM in 2003-2004. The control group was composed of participants without T2DM who were propensity-score-matched, five controls per T2DM patient, according to age, gender, household income, residential area and underlying diseases, including hypertension, dyslipidaemia, coronary heart disease, cerebrovascular disease and thyroid disease...
October 26, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29104610/functional-pancreatic-neuroendocrine-tumour-causing-cushing-s-syndrome-the-effect-of-chemotherapy-on-clinical-symptoms
#15
Paulo Henrique do Amor Divino, Katia Regina Marchetti, Madson Q Almeida, Rachel P Riechelmann
Background: Neuroendocrine tumours (NETs) are a heterogeneous group of diseases that can originate from any part of the gastrointestinal tract, bronchi, thyroid and pancreas. These tumours may be functioning or not depending on their ability to produce active substances, such as adrenocorticotrophic hormone (ACTH). ACTH-producing pancreatic neuroendocrine tumours are rare, with limited data about effective antitumor therapies. Case Report: A 58-year-old man with a history of type-2 diabetes mellitus and arterial hypertension was diagnosed with Cushing's syndrome (CS) secondary to an ACTH ectopic production from a well-differentiated neuroendocrine tumour of the pancreas metastatic to the liver...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29102271/prevalence-of-malnutrition-inflammation-complex-syndrome-and-its-correlation-with-thyroid-hormones-in-chronic-haemodialysis-patients
#16
Venice Chávez Valencia, Oliva Mejía Rodríguez, Martha Eva Viveros Sandoval, Juan Abraham Bermúdez, Sergio Gutiérrez Castellanos, Citlalli Orizaga de la Cruz, Martha Alicia Roa Córdova
INTRODUCTION: Low levels of thyroid hormones, total triiodothyronine (T3) and free triiodothyronine (FT3) in haemodialysis patients is a marker of malnutrition and inflammation and are predictors of mortality. The aim of this study was to determine the prevalence of malnutrition-inflammation complex syndrome in haemodialysis and its relationship with the thyroid hormones thyrotropin, T3, FT3 and free thyroxine (FT4), as well as to evaluate the prevalence of low FT3 syndrome and its correlation with nutritional and inflammatory markers...
October 25, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29101247/evidence-of-earlier-thyroid-dysfunction-in-newly-diagnosed-oral-lichen-planus-patients-a-hint-for-endocrinologists
#17
Paolo G Arduino, Dora Karimi, Federico Tirone, Veronica Sciannameo, Fulvio Ricceri, Marco Cabras, Alessio Gambino, Davide Conrotto, Stefano Salzano, Mario Carbone, Roberto Broccoletti
The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29094913/secondary-hypertension-discovering-the-underlying-cause
#18
REVIEW
Lesley Charles, Jean Triscott, Bonnie Dobbs
Most patients with hypertension have no clear etiology and are classified as having primary hypertension. However, 5% to 10% of these patients may have secondary hypertension, which indicates an underlying and potentially reversible cause. The prevalence and potential etiologies of secondary hypertension vary by age. The most common causes in children are renal parenchymal disease and coarctation of the aorta. In adults 65 years and older, atherosclerotic renal artery stenosis, renal failure, and hypothyroidism are common causes...
October 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29069258/early-menarche-and-teenager-pregnancy-as-risk-factors-for-morbid-obesity-among-reproductive-age-women-a-case-control-study
#19
Amanda Gonçalves Neves, Karina Tamy Kasawara, Ana Carolina Godoy-Miranda, Flávio Hideki Oshika, Elinton Adami Chaim, Fernanda Garanhani Surita
OBJECTIVES: The aim of this study was to evaluate potential risk factors, including non-communicable diseases, for morbid obesity in women between 20 and 49 years of age. METHODS: We performed a case-control study with 110 morbidly obese women and 110 women with adequate weight who were matched by age and with a 1:1 case to control ratio. All women were between 20 to 49 years old and non-menopausal. Possible risk factors were evaluated through a self-report questionnaire assessing socio-demographic, obstetric and gynecological characteristics, presence of non-communicable diseases and habits...
October 2017: Clinics
https://www.readbyqxmd.com/read/29048919/does-treatment-of-either-hypothyroidy-or-hyperthyroidy-affect-diurnal-blood-pressure
#20
Mutlu Demirel, Gül Gürsoy, Mehmet Yıldız
OBJECTIVE: Thyroid hormone has well recognized effects on the cardiovascular system. The purpose of this study was to define the influence of treatment of either hypothyroidism and hyperthyroidism on the values and circadial variations of arterial blood pressure measured by ambulatory blood pressure monitoring. MATERIAL AND METHODS: The study was carried out on 30 hypothyroidic and 30 hyperthyroidic patients without hypertension and 46 healthy participants. First, all the parameters of the groups, then blood pressure values obtained by ambulatory blood pressure monitoring before and after treatment (thyroid hormone replacement with levothyroxine and antithyroid treatment either with propylthyrouracil or metimazole) were compared...
September 2017: Archives of Iranian Medicine
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