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Drug induced nutrient insufficiency

Katarzyna Zabłocka-Słowińska, Ewelina Dzielska, Iwona Gryszkin, Halina Grajeta
BACKGROUND: The classification of dietary supplements as foodstuffs promotes widespread access to them and increases the possibility of patients using them without being monitored. Unreasonable or excessive consumption of these preparations poses risks to type-2 diabetes mellitus (T2DM) patients (among others) because it may induce disturbances in glycemic control. The aim of this study was to assess the frequency of dietary supplementation among patients using anti-diabetic drugs and such patients' nutrient intake in order to evaluate the potential risk of interactions...
November 2014: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Shingo Matsumoto, Keita Saito, Yoichi Takakusagi, Masayuki Matsuo, Jeeva P Munasinghe, Herman D Morris, Martin J Lizak, Hellmut Merkle, Keiji Yasukawa, Nallathamby Devasahayam, Sankaran Suburamanian, James B Mitchell, Murali C Krishna
AIMS: The tumor microenvironment is characterized by a highly reducing redox status, a low pH, and hypoxia. Anti-angiogenic therapies for solid tumors frequently function in two steps: the transient normalization of structurally and functionally aberrant tumor blood vessels with increased blood perfusion, followed by the pruning of tumor blood vessels and the resultant cessation of nutrients and oxygen delivery required for tumor growth. Conventional anatomic or vascular imaging is impractical or insufficient to distinguish between the two steps of tumor response to anti-angiogenic therapies...
September 10, 2014: Antioxidants & Redox Signaling
Mingyu Li, Lisette A Maddison, Patrick Page-McCaw, Wenbiao Chen
Insulin from islet β-cells maintains glucose homeostasis by stimulating peripheral tissues to remove glucose from circulation. Persistent elevation of insulin demand increases β-cell number through self-replication or differentiation (neogenesis) as part of a compensatory response. However, it is not well understood how a persistent increase in insulin demand is detected. We have previously demonstrated that a persistent increase in insulin demand by overnutrition induces compensatory β-cell differentiation in zebrafish...
April 1, 2014: American Journal of Physiology. Endocrinology and Metabolism
M Kadyrov, G Moser, W Rath, N Kweider, C J Wruck, T Pufe, B Huppertz
Pregnancy-related complications not only represent a risk for maternal and fetal morbidity and mortality, but are also a risk for several diseases later in life. Many epidemiological studies have shown clear associations between an adverse intrauterine environment and an increased risk of diabetes, hypertension, cardiovascular disease, depression, obesity, and other chronic diseases in the adult. Some of these syndromes could be prevented by avoiding adverse stimuli or insults including psychological stress during pregnancy, intake of drugs, insufficient diet and substandard working conditions...
June 2013: Zeitschrift Für Geburtshilfe und Neonatologie
Niloufar Mohammadpour, Sepideh Elyasi, Naser Vahdati, Amir Hooshang Mohammadpour, Jamal Shamsara
: Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced especially for cyclosporine, tacrolimus, sirolimus and mycophenolic acid. CYCLOSPORINE: Therapeutic monitoring of immunosuppressive therapy with cyclosporine is a critical requirement because of intra- and inter-patient variability of drug absorption, narrow therapeutic window and drug induced nephrotoxicity...
November 2011: Iranian Journal of Basic Medical Sciences
Chengqian Yin, Shuo Qie, Nianli Sang
Cancer cell proliferation and progression require sufficient supplies of nutrients including carbon sources, nitrogen sources, and molecular oxygen. Particularly, carbon sources and molecular oxygen are critical for the generation of ATP and building blocks, and for the maintenance of intracellular redox status. However, solid tumors frequently outgrow the blood supply, resulting in nutrient insufficiency. Accordingly, cancer cell metabolism shows aberrant biochemical features that are consequences of oncogenic signaling and adaptation...
2012: Critical Reviews in Eukaryotic Gene Expression
Yan Xie, Shuang Chen, Chun-Hui Wang, Cheng-Wei Tang
A new non-cytotoxic therapy that SOM230 (pasireotide),a somatostatin analogue (SSTA) combined with celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor was tested in nude mice bearing HepG2 xenografts. Two agents did not markedly arrest the growth of HepG2 cells but greatly down-regulated vascular endothelial growth factor expression. An imbalance between the vigorous demand and insufficient supply of nutrients and oxygen for tumor growth resulted in the massive necrosis of xenografts. The combination synergistically induced the early apoptosis of HepG2 cells and achieved longest survival without adverse reaction...
July 1, 2011: Cancer Biology & Therapy
Su Yeon Lee, Eui-Kyong Jeong, Hyun Min Jeon, Cho Hee Kim, Ho Sung Kang
Three-dimensional (3D) multicellular tumour spheroids (MTS) have been used as an in vitro model of solid tumours for drug resistance studies because they mimic the growth characteristics of in vivo tumours more closely than in vitro two-dimensional (2D) culture of cancer cell lines. As observed in solid tumours, MTS exhibits a proliferation gradient with outer regions consisting of proliferating cells that surround inner quiescent cells. The innermost cells in core regions undergo cell death mostly by necrosis to form necrotic core due to insufficient supply of oxygen and nutrient such as glucose with increasing size of spheroids...
July 2010: Oncology Reports
Kazi Jahangir Hossain, Md Mustafa Kamal, Monira Ahsan, S K Nazrul Islam
BACKGROUND: Use of illicit drugs induces multiple nutrient deficiencies. Drug habit, sexual practice and socioeconomic factors influence the nutrient profile of drug dependent subjects. The literature on this issue is still insufficient. This study has tested the hypothesis that illicit drug use and lifestyle impair mineral status. To test this hypothesis, 253 men multiple drug users of age 18-45 years were recruited to investigate their serum copper, zinc and iron levels. Influence of illicit drugs and their lifestyle on the mineral levels was also examined...
2007: Substance Abuse Treatment, Prevention, and Policy
E D Jacobson, R H Gallavan, J D Fondacaro
A model of the mesenteric microcirculation is proposed that explains three observed variations in the hyperemic response of the small intestine to different dilator stimuli. The model assumes a two-component circulation in which one component delivers more than enough blood flow and oxygen to meet the metabolic demands of the resting tissue served by this "flow-independent component." The second portion, known as the "flow-limited component" delivers an insufficient blood supply for tissue needs and, therefore, restricts the metabolism of the parenchyma it serves...
June 1982: American Journal of Physiology
S Takki, J Heinonen, E Taskinen
No abstract text is available yet for this article.
1972: Archiv Für Toxikologie
G Zagara, L Locati
Total parenteral nutrition (TPN) rich in glucose may cause a deposition of triglycerides in the liver with consequent steatosis. We have valued the role of different nutrients in the determinism of liver failure. Sixty-five patients with severe and isolated head trauma (GCS score of 7 or less), 50 men and 15 women, of mean age 28 years (range: 15-68 years) were prospectively studied. All patients have a negative history for liver disease. In 24 randomly selected patients only glucose (group G) was administered as non-protein caloric source, while other 41 patients received glucose and Intralipid 10% (group GL) in ratio 70:30...
December 1989: Minerva Anestesiologica
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