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https://www.readbyqxmd.com/read/27856651/flat-detector-computed-tomography-pbv-map-in-the-evaluation-of-presurgical-embolization-for-hypervascular-brain-tumors
#1
Li-Li Wen, Xin Zhang, Qing-Rong Zhang, Qi Wu, Shu-Juan Chen, Jin-Long Deng, Kaiyi Huang, Han-Dong Wang
BACKGROUND: Preoperative embolization of hypervascular brain tumors is frequently used to minimize intraoperative bleeding. OBJECTIVE: To explore the efficacy of embolization using flat-detector CT (FDCT) parenchymal blood volume (PBV) maps before and after the intervention. MATERIALS AND METHODS: Twenty-five patients with hypervascular brain tumors prospectively received pre- and postprocedural FDCT PBV scans using a biplane system under a protocol approved by the institutional research ethics committee...
November 17, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27833318/intracranial-meningioma-mimicking-brain-metastasis-on-18-f-sodium-fluoride-bone-scan-in-a-case-of-carcinoma-cervix
#2
Rollapeta Ramya Priya, Ranadheer Gupta Manthri, Amancharla Yadagiri Lakshmi, Tekchand Kalawat
Bone scintigraphy (BS) is a well--established commonly used imaging modality for staging and follow--up evaluation of cancer patients. Occasionally, BS may show asymptomatic unusual extraosseous lesions in the body which may or may not be related to primary disease. We here present an interesting case of carcinoma cervix in whom (18)F sodium fluoride positron emission tomography-computerized tomography (PET-CT) bone scan detected an intracranial lesion. Initially, this lesion was suspected as brain metastasis; however, later on, combined PET--CT images and contrast-enhanced CT confirmed this lesion as calcified falcine meningioma in the right posterior parietal region...
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27826238/age-dependent-cortical-thinning-of-peripheral-visual-field-representations-in-primary-visual-cortex
#3
Joseph C Griffis, Wesley K Burge, Kristina M Visscher
The cerebral cortex changes throughout the lifespan, and the cortical gray matter in many brain regions becomes thinner with advancing age. Effects of aging on cortical thickness (CT) have been observed in many brain regions, including areas involved in basic perceptual functions such as processing visual inputs. An important property of early visual cortices is their topographic organization-the cortical structure of early visual areas forms a topographic map of retinal inputs. Primary visual cortex (V1) is considered to be the most basic cortical area in the visual processing hierarchy, and is topographically organized from posterior (central visual representation) to anterior (peripheral visual representation) along the calcarine sulcus...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27818357/the-role-of-neuropathological-markers-in-the-interpretation-of-neuropsychiatric-disorders-focus-on-fetal-and-perinatal-programming
#4
REVIEW
Fanni Daniela, Gerosa Clara, Rais Monica, Ravarino Alberto, Van Eyken Peter, Fanos Vassilios, Faa Gavino
The study of neuropathological markers in patients affected by mental/psychiatric disorders is relevant for the comprehension of the pathogenesis and the correlation with the clinical symptomatology. The neuropathology of Alzheimer's disease (AD) recognizes intraneuronal and extracellular neurofibrillary formation responsible for neuronal degeneration. Immunohistochemical studies discovered many interesting results for a better interpretation of the AD pathogenesis, while the "metal hypothesis" supports that metal ions might differentially influence the formation of amyloid aggregates...
November 3, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27807831/quantitative-clinical-imaging-methods-for-monitoring-intratumoral-evolution
#5
Joo Yeun Kim, Robert A Gatenby
Solid tumors are multiscale, open, complex, dynamic systems: complex because they have many interacting components, dynamic because both the components and their interactions can change with time, and open because the tumor freely communicates with surrounding and even distant host tissue. Thus, it is not surprising that striking intratumoral variations are commonly observed in clinical imaging such as MRI and CT and that several recent studies found striking regional variations in the molecular properties of cancer cells from the same tumor...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27769824/a-study-of-the-feasibility-of-fdg-pet-ct-to-systematically-detect-and-quantify-differential-metabolic-effects-of-chronic-tobacco-use-in-organs-of-the-whole-body-a-prospective-pilot-study
#6
Drew A Torigian, Judith Green-McKenzie, Xianling Liu, Frances S Shofer, Thomas Werner, Catherine E Smith, Andrew A Strasser, Mateen C Moghbel, Ami H Parekh, Grace Choi, Marcus D Goncalves, Natalie Spaccarelli, Saied Gholami, Prithvi S Kumar, Yubing Tong, Jayaram K Udupa, Clementina Mesaros, Abass Alavi
RATIONALE AND OBJECTIVES: The aim of this study was to assess the feasibility of (18)F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) to systematically detect and quantify differential effects of chronic tobacco use in organs of the whole body. MATERIALS AND METHODS: Twenty healthy male subjects (10 nonsmokers and 10 chronic heavy smokers) were enrolled. Subjects underwent whole-body FDG-PET/CT, diagnostic unenhanced chest CT, mini-mental state examination, urine testing for oxidative stress, and serum testing...
October 18, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27753725/shortened-mean-transit-time-in-ct-perfusion-with-singular-value-decomposition-analysis-in-acute-cerebral-infarction-quantitative-evaluation-and-comparison-with-various-ct-perfusion-parameters
#7
Kazuhiro Murayama, Kazuhiro Katada, Motoharu Hayakawa, Hiroshi Toyama
OBJECTIVE: We aimed to clarify the cause of shortened mean transit time (MTT) in acute ischemic cerebrovascular disease and examined its relationship with reperfusion. METHODS: Twenty-three patients with acute ischemic cerebrovascular disease underwent whole-brain computed tomography perfusion (CTP). The maximum MTT (MTTmax), minimum MTT (MTTmin), ratio of maximum and minimum MTT (MTTmin/max), and minimum cerebral blood volume (CBV) (CBVmin) were measured by automatic region of interest analysis...
October 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27686551/-preliminary-study-on-assessment-of-lexiscan-induced-blood-brain-barrier-opening-and-its-level-by-ct-perfusion-imaging
#8
Y Duan, B Q Yang, C C Chang, J Zhou, H Y Li, Z H Xu, Z W Wang, D Y Li
Objective: To evaluate the level of lexiscan-induced blood-brain barrier opening of healthy rabbits via CT perfusion weighted imaging (PWI) scan. Methods: Between November 2014 and May 2015, thirty New Zealand white rabbits were randomly assigned into three groups: the experimental group A1 which received one injection of lexiscan(1 ml/kg); the experimental group A2 which received three times injection of lexiscan(total dose: 1.5 ml/kg), finished within 15 minutes; the control group B which was injected the same volume normal saline(1 ml/kg), after 30 minutes, CT PWI scan was performed...
September 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27660145/biodistribution-and-radiation-dosimetry-of-c-11-nicotine-from-whole-body-pet-imaging-in-humans
#9
Pradeep K Garg, Stephen J Lokitz, Rachid Nazih, Sudha Garg
: The main focus of this study was to assess the in vivo distribution and radiation absorbed dose of (11)C-nicotine derived from the whole body Positron emission tomography (PET) imaging in humans. METHODS: After an initial Computed tomography (CT) attenuation scan, (11)C-nicotine was administered via an intravenous injection, and dynamic whole body PET scans were acquired in a 3-D mode on 11 normal healthy (5 male, 6 female) subjects. The first scan was acquired in a dynamic acquisition mode for 90 s with the brain in the field of view, followed by a series of whole body PET scans acquired over a 90 min time period...
September 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27569917/gray-matter-white-matter-de-differentiation-on-brain-computed-tomography-predicts-brain-death-occurrence
#10
C Vigneron, V Labeye, M Cour, S Hannoun, A Grember, F Rampon, F Cotton
BACKGROUND: Previous studies have shown that a loss of distinction between gray matter (GM) and white matter (WM) on unenhanced CT scans was predictive of poor outcome after cardiac arrest. The aim of this study was to identify a marker/predictor of imminent brain death. METHODS: In this retrospective study, 15 brain-dead patients after anoxia and cardiac arrest were included. Patients were paired (1:1) with normal control subjects. Only patients' unenhanced CT scans performed before brain death and during the 24 hours after initial signs were analyzed...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27564785/the-application-of-adult-traumatic-brain-injury-models-in-a-pediatric-cohort
#11
Adam M H Young, Mathew R Guilfoyle, Helen Fernandes, Matthew R Garnett, Shruti Agrawal, Peter J Hutchinson
OBJECTIVE There is increasing interest in the use of predictive models of outcome in adult head injury. Two international models have been identified to be reliable modalities for predicting outcome: the Corticosteroid Randomisation After Significant Head Injury (CRASH) model, and the International Mission on Prognosis and Analysis of randomized Controlled Trials in TBI (IMPACT) model. However, these models are designed only to identify outcomes in adult populations. METHODS A retrospective analysis was performed on pediatric patients with severe traumatic brain injury (TBI) admitted to the pediatric intensive care unit (PICU) of Addenbrooke's Hospital between January 2009 and December 2013...
August 26, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27557149/time-dependent-changes-in-dural-enhancement-associated-with-spontaneous-intracranial-hypotension
#12
Peter G Kranz, Timothy J Amrhein, Kingshuk Roy Choudhury, Teerath Peter Tanpitukpongse, Linda Gray
OBJECTIVE: The objective of our study was to determine whether the presence of individual imaging signs of spontaneous intracranial hypotension (SIH) is correlated with increasing duration of headache symptoms. Of particular interest is the relationship of symptom duration to dural enhancement because it is the most commonly identified imaging sign in patients with SIH. MATERIALS AND METHODS: Eighty-nine patients with SIH who underwent pretreatment brain MRI and total-spine CT myelography and whose medical record included data on the duration of clinical symptoms were included in this cross-sectional retrospective study...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27540426/comparison-of-the-performances-of-18-f-fp-cit-brain-pet-mr-and-simultaneous-pet-ct-a-preliminary-study
#13
SangDon Kwon, KyungAh Chun, EunJung Kong, IhnHo Cho
PURPOSE: (18)F-FP-CIT [(18)F-fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane] has been well established and used for the differential diagnosis of atypical parkinsonian disorders. Recently, combined positron emission tomography (PET)/magnetic resonance (MR) was proposed as a viable alternative to PET/computed tomography (CT). The aim of this study was to compare the performances of conventional (18)F-FP-CIT brain PET/CT and simultaneous PET/MR by visual inspection and quantitative analysis...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27495819/visual-fixation-in-the-icu-a-strong-predictor-of-long-term-recovery-after-moderate-to-severe-traumatic-brain-injury
#14
Caroline Arbour, Andrée-Ann Baril, Harrison J Westwick, Marie-Julie Potvin, Danielle Gilbert, Jean-François Giguère, Gilles J Lavigne, Alex Desautels, Francis Bernard, Steven Laureys, Nadia Gosselin
OBJECTIVE: Posttraumatic amnesia is superior to the initial Glasgow Coma Scale score for predicting traumatic brain injury recovery, but it takes days/weeks to assess. Here, we examined whether return of visual fixation-a potential marker of higher cognitive function-within 24 hours of ICU admission could be used as an early predictor of traumatic brain injury recovery. DESIGN: Two-phase cohort study. SETTING: Level-I trauma ICU. PATIENTS: Moderate-to-severe traumatic brain injury discharged alive between 2010 and 2013...
August 5, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27476687/to-retain-or-remove-the-bone-flap-during-evacuation-of-acute-subdural-hematoma-factors-associated-with-perioperative-brain-edema
#15
Ha Nguyen, Karl Janich, Ashish Sharma, Mohit Patel, Wade Mueller
INTRODUCTION: The fate of the bone flap is a significant decision during surgical treatment of acute subdural hematoma (SDH). A general guideline revolves around the surgeon's concern for brain edema. However, limited studies have focused on the factors that contribute to perioperative brain edema. We proposed that assessment of brain volume via CT imaging in patients without bone flaps is a reasonable model to study brain edema. METHODS: From 2012 to 2015, 38 patients who underwent decompressive craniectomy for acute SDH were reviewed...
July 28, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27418267/phase-iia-clinical-study-of-18-f-fluciclovine-efficacy-and-safety-of-a-new-pet-tracer-for-brain-tumors
#16
Akihide Kondo, Hisato Ishii, Shigeki Aoki, Masaru Suzuki, Hidekazu Nagasawa, Kazuo Kubota, Ryogo Minamimoto, Atsushi Arakawa, Masato Tominaga, Hajime Arai
OBJECTIVE: [(18)F]Fluciclovine (anti-[(18)F]FACBC) has demonstrated diagnostic efficacy for cancers of the brain where [(18)F]fludeoxyglucose has limitations. We conducted a phase IIa study of anti-[(18)F]FACBC to assess its accumulation pattern and safety in patients with malignant glioma. METHODS: Five patients with glioma scheduled for brain tumor resection received anti-[(18)F]FACBC. Brain positron emission tomography (PET) was performed following intravenous administration of anti-[(18)F]FACBC, and subsequently, preoperative gadolinium contrast-enhanced T1-weighted (CE-T1W) magnetic resonance imaging (MRI) was performed for surgery...
July 14, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27408895/evaluation-of-iterative-reconstruction-method-and-attenuation-correction-in-brain-dopamine-transporter-spect-using-an-anthropomorphic-striatal-phantom
#17
Akira Maebatake, Ayaka Imamura, Yui Kodera, Yasuo Yamashita, Kazuhiko Himuro, Shingo Baba, Kenta Miwa, Masayuki Sasaki
OBJECTIVES: The aim of this study was to determine the optimal reconstruction parameters for iterative reconstruction in different devices and collimators for dopamine transporter (DaT) single-photon emission computed tomography (SPECT). The results were compared between filtered back projection (FBP) and different attenuation correction (AC) methods. METHODS: An anthropomorphic striatal phantom was filled with (123)I solutions at different striatum-to-background radioactivity ratios...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27399416/137%C3%A2-an-easily-implemented-open-access-semiautomated-pipeline-for-intracranial-electrode-localization
#18
Timothy G Dyster, Yagna Pathak, Elliot Smith, Sameer A Sheth
INTRODUCTION: Patients with medically refractory epilepsy often require intracranial electrode implantation for seizure localization. As the use of these procedures continues to increase, the demand for simpler and more efficient methods of electrode localization methods has grown. We developed a semiautomated pipeline to localize electrode contacts using multimodal neuroimaging data. METHODS: Our pipeline coregisters the preoperative MRI and the postoperative CT for each patient using a rigid body transformation and scaling to align electrodes in patient-specific anatomy...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27365962/deadly-intracranial-bleed-in-patients-with-dengue-fever-a-series-of-nine-patients-and-review-of-literature
#19
Jo Ee Sam, Teak Sheng Gee, Abdul Wahab Nasser
INTRODUCTION: Dengue fever is a global pandemic threat with increasing incidence. To date, there are no cures and the effectiveness of dengue vaccines is still uncertain. World Heath Organization introduced expanded dengue syndrome to include unusual presentations of dengue fever including severe neurologic complications. One of the deadly complications is intracranial hemorrhage (ICH). METHODOLOGY: We collected data of patients with ICH diagnosed via a plain computed tomography of the brain (CT brain) with thrombocytopenia and positive Dengue virus type 1 nonstructural protein (NS1) antigen test or positive dengue serology IgM from January 2014 till June 2015 at our center...
July 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27351242/automatic-quantification-of-multi-modal-rigid-registration-accuracy-using-feature-detectors
#20
F Hauler, H Furtado, M Jurisic, S H Polanec, C Spick, A Laprie, U Nestle, U Sabatini, W Birkfellner
In radiotherapy, the use of multi-modal images can improve tumor and target volume delineation. Images acquired at different times by different modalities need to be aligned into a single coordinate system by 3D/3D registration. State of the art methods for validation of registration are visual inspection by experts and fiducial-based evaluation. Visual inspection is a qualitative, subjective measure, while fiducial markers sometimes suffer from limited clinical acceptance. In this paper we present an automatic, non-invasive method for assessing the quality of intensity-based multi-modal rigid registration using feature detectors...
July 21, 2016: Physics in Medicine and Biology
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