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Exhaled propofol

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https://www.readbyqxmd.com/read/27478615/procedural-sedation-and-analgesia-for-respiratory-gated-mr-hifu-in-the-liver-a-feasibility-study
#1
Johanna M M van Breugel, Joost W Wijlemans, Hermanus H B Vaessen, Martijn de Greef, Chrit T W Moonen, Maurice A A J van den Bosch, Mario G Ries
BACKGROUND: Previous studies demonstrated both pre-clinically and clinically the feasibility of magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) ablations in the liver. To overcome the associated problem of respiratory motion of the ablation area, general anesthesia (GA) and mechanical ventilation was used in conjunction with either respiratory-gated energy delivery or energy delivery during induced apnea. However, clinical procedures requiring GA are generally associated with increased mortality, morbidity, and complication rate compared to procedural sedation and analgesia (PSA)...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/26715214/propofol-breath-monitoring-as-a-potential-tool-to-improve-the-prediction-of-intraoperative-plasma-concentrations
#2
Pieter Colin, Douglas J Eleveld, Johannes P van den Berg, Hugo E M Vereecke, Michel M R F Struys, Gustav Schelling, Christian C Apfel, Cyrill Hornuss
INTRODUCTION: Monitoring of drug concentrations in breathing gas is routinely being used to individualize drug dosing for the inhalation anesthetics. For intravenous anesthetics however, no decisive evidence in favor of breath concentration monitoring has been presented up until now. At the same time, questions remain with respect to the performance of currently used plasma pharmacokinetic models implemented in target-controlled infusion systems. In this study, we investigate whether breath monitoring of propofol could improve the predictive performance of currently applied, target-controlled infusion models...
July 2016: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/26645243/-chemosensory-evoked-changes-of-breathing-pattern-during-propofol-induced-sedation
#3
H Gudziol, R Gottschall, D Geil, H Lehnich, T Bitter, O Guntinas-Lichius
BACKGROUND: The affective valence of an olfactory stimulus will be encoded in its respiratory response. Unpleasant odors shorten the inhalation of the first stimulated breaths in wakefulness and sleep. The aim of the present study was to assess the effekt of intravenous anesthetic propofol on the chemosensory evoked changes of breathing pattern. MATERIAL AND METHODS: 13 ASA 1/2 patients got intranasal chemosensory stimuli (H2S and CO2) by flow-olfactometer during "deep" (EEG-based bispectral analysis, BIS:≤60) and "moderate" (BIS>60) propofol-induced sedation with preserved spontaneous breathing...
June 2016: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/25749754/electrochemical-sensor-system-for-breath-analysis-of-aldehydes-co-and-no
#4
J Obermeier, P Trefz, K Wex, B Sabel, J K Schubert, W Miekisch
Bulky and hyphenated laboratory-based analytical instrumentation such as gas chromatography/mass spectrometry is still required to trace breath biomarkers in the low ppbV level. Innovative sensor-based technologies could provide on-site and point-of-care (POC) detection of volatile biomarkers such as breath aldehydes related to oxidative stress and cancer. An electrochemical sensor system was developed for direct detection of the total abundance of aldehydes in exhaled breath in the ppbV level and for simultaneous determination of the airway inflammation markers carbon monoxide (CO) and nitric oxide (NO)...
March 2015: Journal of Breath Research
https://www.readbyqxmd.com/read/25565144/online-breath-analysis-of-propofol-during-anesthesia-clinical-application-of-membrane-inlet-ion-mobility-spectrometry
#5
Y Liu, Y Gong, C Wang, X Wang, Q Zhou, D Wang, L Guo, X Pi, X Zhang, S Luo, H Li, E Li
BACKGROUND: Breath analysis of propofol is a potential noninvasive method for approximating the plasma propofol concentration. There have been various reported techniques for measuring the exhaled propofol concentration at steady state; however, the propofol concentration undergoes marked changes during clinical anesthesia. Therefore, this study investigated the use of membrane inlet-ion mobility spectrometry (MI-IMS) to monitor exhaled propofol discontinuously and continuously during propofol anesthesia...
March 2015: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/25557720/time-resolved-dynamic-dilution-introduction-for-ion-mobility-spectrometry-and-its-application-in-end-tidal-propofol-monitoring
#6
Qinghua Zhou, Enyou Li, Zhenxin Wang, Yulei Gong, Changsong Wang, Lei Guo, Haiyang Li
Based on the adsorption of analytes in the sampling loop, a time-resolved dynamic dilution introduction method was developed for negative ion mobility spectrometry to continuously monitor end-tidal propofol without other sample pre-separation. The dynamic dilution characteristics of propofol and moisture in the Teflon sample loop (4 mm o.d. and 2.4 mm i.d., 150 cm length) were both theoretically and experimentally investigated. The prominent absorption differences between propofol and moisture on the inwall of the sample loop allowed their concentrations to be time-resolved during the injection process, realizing sensitive measurement of end-tidal propofol with a response time of 2 s...
March 2015: Journal of Breath Research
https://www.readbyqxmd.com/read/25368784/volume-controlled-versus-pressure-controlled-ventilation-volume-guaranteed-mode-during-one-lung-ventilation
#7
Seok Young Song, Jin Yong Jung, Min-Su Cho, Jong Hae Kim, Tae Ha Ryu, Bong Il Kim
BACKGROUND: The purpose of this study was to investigate the changes in airway pressure and arterial oxygenation between ventilation modes during one-lung ventilation (OLV) in patients undergoing thoracic surgery. METHODS: We enrolled 27 patients for thoracic surgery with OLV in the lateral decubitus position. The subjects received various modes of ventilation in random sequences during surgery, including volume-controlled ventilation (VCV) and pressure-controlled ventilation-volume guaranteed (PCV-VG) with a tidal volume (TV) of 8 ml/kg of actual body weight...
October 2014: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/25331152/improved-analytical-performance-of-negative-63ni-ion-mobility-spectrometry-for-on-line-measurement-of-propofol-using-dichloromethane-as-dopant
#8
Qinghua Zhou, Lei Hua, Changsong Wang, Enyou Li, Haiyang Li
On-line monitoring of propofol in exhaled air is a potential way to evaluate the anaesthesia depth for patients during surgery. In this study, a negative (63)Ni ionization high resolution ion mobility spectrometer with Bradbury-Nielsen-Gate-Grid structure was built to measure propofol with reactant ions Cl(-)(H2O) n using dichloromethane as dopant. Instead of forming three propofol ions (M - H)(-), M · O2(-), and (M2 - H)(-) with reactant ions O2(-)(H2O)n, only product ion M · Cl(-) was produced when introducing dichloromethane gas...
January 2015: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/25012583/gas-chromatograph-surface-acoustic-wave-for-quick-real-time-assessment-of-blood-exhaled-gas-ratio-of-propofol-in-humans
#9
X Chen, X L Zhang, L Liu, Y Chen, M Y Piao, F J Zhang, W D Wu, Y B Zhong, K Sun, Y C Zou, X Zhang, D Wang, P Wang, M Yan
BACKGROUND: Although pilot studies have reported that exhaled propofol concentrations can reflect intraoperative plasma propofol concentrations in an individual, the blood/exhaled partial pressure ratio RBE varies between patients, and the relevant factors have not yet been clearly addressed. No efficient method has been reported for the quick evaluation of RBE and its association with inter-individual variables. METHODS: We proposed a novel method that uses a surface acoustic wave (SAW) sensor combined with a fast gas chromatograph (GC) to simultaneously detect propofol concentrations in blood and exhaled gas in 28 patients who were receiving propofol i...
November 2014: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/24957852/two-different-approaches-for-pharmacokinetic-modeling-of-exhaled-drug-concentrations
#10
S Kreuer, A Hauschild, T Fink, J I Baumbach, S Maddula, Th Volk
Online measurement of drug concentrations in patient's breath is a promising approach for individualized dosage. A direct transfer from breath- to blood-concentrations is not possible. Measured exhaled concentrations are following the blood-concentration with a delay in non-steady-state situations. Therefore, it is necessary to integrate the breath-concentration into a pharmacological model. Two different approaches for pharmacokinetic modelling are presented. Usually a 3-compartment model is used for pharmacokinetic calculations of blood concentrations...
2014: Scientific Reports
https://www.readbyqxmd.com/read/24946087/the-human-volatilome-volatile-organic-compounds-vocs-in-exhaled-breath-skin-emanations-urine-feces-and-saliva
#11
REVIEW
Anton Amann, Ben de Lacy Costello, Wolfram Miekisch, Jochen Schubert, Bogusław Buszewski, Joachim Pleil, Norman Ratcliffe, Terence Risby
Breath analysis is a young field of research with its roots in antiquity. Antoine Lavoisier discovered carbon dioxide in exhaled breath during the period 1777-1783, Wilhelm (Vilém) Petters discovered acetone in breath in 1857 and Johannes Müller reported the first quantitative measurements of acetone in 1898. A recent review reported 1765 volatile compounds appearing in exhaled breath, skin emanations, urine, saliva, human breast milk, blood and feces. For a large number of compounds, real-time analysis of exhaled breath or skin emanations has been performed, e...
September 2014: Journal of Breath Research
https://www.readbyqxmd.com/read/24836471/capnography-during-deep-sedation-with-propofol-by-nonanesthesiologists-a-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Kim van Loon, Aart T van Rheineck Leyssius, Bas van Zaane, Mirjam Denteneer, Cor J Kalkman
BACKGROUND: Propofol, a short-acting hypnotic drug, is increasingly administered by a diverse group of specialists (e.g., cardiologists, gastroenterologists) during diagnostic and therapeutic procedures. Standard monitoring during sedation comprises continuous pulse oximetry with visual assessment of the patient's breathing pattern. Because undetected hypoventilation is a common pathway for complications, capnographic monitoring of exhaled carbon dioxide has been advocated. We examined whether the use of capnography reduces the incidence of hypoxemia during nonanesthesiologist-administered propofol sedation in patients who did not receive supplemental oxygen routinely...
July 2014: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/24272872/real-time-monitoring-of-exhaled-drugs-by-mass-spectrometry
#13
REVIEW
Christian Berchtold, Marija Bosilkovska, Youssef Daali, Bernhard Walder, Renato Zenobi
Future individualized patient treatment will need tools to monitor the dose and effects of administrated drugs. Mass spectrometry may become the method of choice to monitor drugs in real time by analyzing exhaled breath. This review describes the monitoring of exhaled drugs in real time by mass spectrometry. The biological background as well as the relevant physical properties of exhaled drugs are delineated. The feasibility of detecting and monitoring exhaled drugs is discussed in several examples. The mass spectrometric tools that are currently available to analyze breath in real time are reviewed...
September 2014: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/23525901/determination-of-breath-isoprene-allows-the-identification-of-the-expiratory-fraction-of-the-propofol-breath-signal-during-real-time-propofol-breath-monitoring
#14
Cyrill Hornuss, Michael E Dolch, Silke Janitza, Kimberly Souza, Siegfried Praun, Christian C Apfel, Gustav Schelling
Real-time measurement of propofol in the breath may be used for routine clinical monitoring. However, this requires unequivocal identification of the expiratory phase of the respiratory propofol signal as only expiratory propofol reflects propofol blood concentrations. Determination of CO2 breath concentrations is the current gold standard for the identification of expiratory gas but usually requires additional equipment. Human breath also contains isoprene, a volatile organic compound with low inspiratory breath concentration and an expiratory concentration plateau...
October 2013: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/23357660/abdominal-relaxation-during-emergence-from-general-anesthesia-with-propofol-and-remifentanil
#15
Joshua H Atkins, Jeff E Mandel
STUDY OBJECTIVE: To characterize respiratory dynamics during emergence from propofol-remifentanil anesthesia using noninvasive respiratory inductance plethysmography (RIP). DESIGN: Observational pilot study. SETTING: Operating room in a university-affiliated teaching hospital. PATIENTS: 50 ASA physical status 1, 2, and 3 patients scheduled for microdirect laryngoscopy or bronchoscopy using total intravenous anesthesia (TIVA) with high-frequency jet ventilation...
March 2013: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/22984587/breath-pentane-as-a-potential-biomarker-for-survival-in-hepatic-ischemia-and-reperfusion-injury-a-pilot-study
#16
Changsong Wang, Jinghui Shi, Bo Sun, Desheng Liu, Peng Li, Yulei Gong, Ying He, Shujuan Liu, Guowang Xu, Jianyi Li, Ailin Luo, Enyou Li
BACKGROUND: Exhaled pentane, which is produced as a consequence of reactive oxygen species-mediated lipid peroxidation, is a marker of oxidative stress. Propofol is widely used as a hypnotic agent in intensive care units and the operating room. Moreover, this agent has been reported to inhibit lipid peroxidation by directly scavenging reactive oxygen species. In this study, using a porcine liver ischemia-reperfusion injury model, we have evaluated the hypothesis that high concentrations of breath pentane are related to adverse outcome and that propofol could reduce breath pentane and improve liver injury and outcome in swine in this situation...
2012: PloS One
https://www.readbyqxmd.com/read/22939154/on-line-measurement-of-propofol-using-membrane-inlet-ion-mobility-spectrometer
#17
Qinghua Zhou, Weiguo Wang, Huaiwen Cang, Yongzhai Du, Fenglei Han, Chuang Chen, Shasha Cheng, Jinghua Li, Haiyang Li
The concentration of propofol in patient's exhaled air is an indicator of the anesthetic depth. In the present study, a membrane inlet ion mobility spectrometer (MI-IMS) was built for the on-line measurement of propofol. Compared with the direct sample introduction, the membrane inlet could eliminate the interference of moisture and improve the selectivity of propofol. Effects of membrane temperature and carrier gas flow rate on the sensitivity and response time have been investigated experimentally and theoretically...
August 30, 2012: Talanta
https://www.readbyqxmd.com/read/22370587/time-course-of-expiratory-propofol-after-bolus-injection-as-measured-by-ion-molecule-reaction-mass-spectrometry
#18
Cyrill Hornuss, Dirk Wiepcke, Siegfried Praun, Michael E Dolch, Christian C Apfel, Gustav Schelling
Propofol in exhaled breath can be detected and monitored in real time by ion molecule reaction mass spectrometry (IMR-MS). In addition, propofol concentration in exhaled breath is tightly correlated with propofol concentration in plasma. Therefore, real-time monitoring of expiratory propofol could be useful for titrating intravenous anesthesia, but only if concentration changes in plasma can be determined in exhaled breath without significant delay. To evaluate the utility of IMR-MS during non-steady-state conditions, we measured the time course of both expiratory propofol concentration and the processed electroencephalography (EEG) as a surrogate outcome for propofol effect after an IV bolus induction of propofol...
April 2012: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/21717028/on-line-real-time-monitoring-of-exhaled-trace-gases-by-sift-ms-in-the-perioperative-setting-a-feasibility-study
#19
Piers R Boshier, Julia R Cushnir, Vikash Mistry, Alison Knaggs, Patrik Španěl, David Smith, George B Hanna
A study is described of the first on line, real time analyses of the exhaled breath of five anaesthetized patients during the complete perioperative periods of laparoscopic surgery. These breath analyses were achieved using a selected ion flow tube, SIFT-MS, instrument, located in the operating theatre at an acceptable distance from the operating table, and coupled to the endotracheal tube in the ventilation circuit via a 5 metre long capillary tube. Thus, inhalation/exhalation breathing cycles, set to be at a frequency of 10 per minute, were sampled continuously for water vapour, the metabolites acetone and isoprene and the propofol used to induce anaesthesia for each operating period that ranged from 20 min (shortest) to 80 min (longest)...
August 21, 2011: Analyst
https://www.readbyqxmd.com/read/21643859/drug-detection-in-breath-effects-of-pulmonary-blood-flow-and-cardiac-output-on-propofol-exhalation
#20
Svend Kamysek, Patricia Fuchs, Henny Schwoebel, Jan P Roesner, Sabine Kischkel, Kathi Wolter, Christian Loeseken, Jochen K Schubert, Wolfram Miekisch
Breath analysis could offer a non-invasive means of intravenous drug monitoring if robust correlations between drug concentrations in breath and blood can be established. In this study, propofol blood and breath concentrations were determined in an animal model under varying physiological conditions. Propofol concentrations in breath were determined by means of two independently calibrated analytical methods: continuous, real-time proton transfer reaction mass spectrometry (PTR-MS) and discontinuous solid-phase micro-extraction coupled with gas chromatography mass spectrometry (SPME-GC-MS)...
October 2011: Analytical and Bioanalytical Chemistry
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