keyword
MENU ▼
Read by QxMD icon Read
search

Nile Virus

keyword
https://www.readbyqxmd.com/read/29142017/modelling-the-effects-of-phylogeny-and-body-size-on-within-host-pathogen-replication-and-immune-response
#1
Soumya Banerjee, Alan S Perelson, Melanie Moses
Understanding how quickly pathogens replicate and how quickly the immune system responds is important for predicting the epidemic spread of emerging pathogens. Host body size, through its correlation with metabolic rates, is theoretically predicted to impact pathogen replication rates and immune system response rates. Here, we use mathematical models of viral time courses from multiple species of birds infected by a generalist pathogen (West Nile Virus; WNV) to test more thoroughly how disease progression and immune response depend on mass and host phylogeny...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29141749/visualization-of-west-nile-virus-in-urine-sediment-using-electron-microscopy-and-immunogold-up-to-nine-years-postinfection
#2
Kristy O Murray, Steven Kolodziej, Shannon E Ronca, Rodion Gorchakov, Patricia Navarro, Melissa S Nolan, Amber Podoll, Kevin Finkel, Sreedhar Mandayam
West Nile virus (WNV) is an important emerging flavivirus in North America. Experimental studies in animals infer the development of persistent infection in the kidneys. In humans, recent studies suggest the possibility of persistent renal infection and chronic kidney disease. Considering the discrepancies between published studies on viral RNA detection in urine of convalescing WNV-positive patients, we explored the use of electron microscopy (EM) with anti-WNV E protein antibody immunogold labeling to detect virus in the urine sediment from a subset of study participants in the Houston WNV cohort...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29131357/zika-virus-what-we-need-to-know
#3
REVIEW
Farakh Javed, Khanzadi N Manzoor, Mubashar Ali, Irshad U Haq, Abid A Khan, Assad Zaib, Sobia Manzoor
Zika virus is one of the emerging viruses and is of significant threat to human health globally. It is a mosquito borne flavivirus similar to dengue, yellow fever, and West Nile viruses. It was reported about 5 decades ago and then it spreads to different parts of the world. Large outbreaks were reported on Yap Islands in 2007. Now it has gained wide attention globally by health communities. Major vector for virus transmission is Aedes aegypti mosquito. ZIKV infection is mostly asymptomatic but it is also responsible to cause mild influenza like illness to serious manifestations...
November 13, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29128516/west-nile-virus-anopheles-flavivirus-a-novel-flavivirus-as-well-as-merida-like-rhabdovirus-turkey-in-field-collected-mosquitoes-from-thrace-and-anatolia
#4
Ceren Öncü, Annika Brinkmann, Filiz Günay, Sırrı Kar, Kerem Öter, Yasemen Sarıkaya, Andreas Nitsche, Yvonne-Marie Linton, Bülent Alten, Koray Ergünay
Mosquitoes are involved in the transmission and maintenance of several viral diseases with significant health impact. Biosurveillance efforts have also revealed insect-specific viruses, observed to cocirculate with pathogenic strains. This report describes the findings of flavivirus and rhabdovirus screening, performed in eastern Thrace and Aegean region of Anatolia during 2016, including and expanding on locations with previously-documented virus activity. A mosquito cohort of 1545 individuals comprising 14 species were collected and screened in 108 pools via generic and specific amplification and direct metagenomics by next generation sequencing...
November 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29121099/dengue-virus-ns1-cytokine-independent-vascular-leak-is-dependent-on-endothelial-glycocalyx-components
#5
Dustin R Glasner, Kalani Ratnasiri, Henry Puerta-Guardo, Diego A Espinosa, P Robert Beatty, Eva Harris
Dengue virus (DENV) is the most prevalent, medically important mosquito-borne virus. Disease ranges from uncomplicated dengue to life-threatening disease, characterized by endothelial dysfunction and vascular leakage. Previously, we demonstrated that DENV nonstructural protein 1 (NS1) induces endothelial hyperpermeability in a systemic mouse model and human pulmonary endothelial cells, where NS1 disrupts the endothelial glycocalyx-like layer. NS1 also triggers release of inflammatory cytokines from PBMCs via TLR4...
November 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29120567/use-of-the-vectortest-for-advanced-warning-of-human-west-nile-virus-cases-in-mississippi
#6
Wendy C Varnado, Jerome Goddard
West Nile virus (WNV) continues to persist in Mississippi; 2012 was the worse year for human infections, with a total of 247 reported human cases and five deaths. Public health officials are keenly interested in ways to detect WNV in advance in their jurisdictions, so they can implement appropriate and timely mosquito control in affected areas. A total of 40,312 female Culex quinquefasciatus mosquitoes were collected by gravid traps in Mississippi in 2013 and 2014 and tested by VectorTest, a rapid immunochromatographic assay (“dip-stick” test) that is a highly specific and effective rapid threat assessment tool...
December 2016: Journal of Environmental Health
https://www.readbyqxmd.com/read/29119349/southern-california-neuroinvasive-west-nile-virus-case-series
#7
Chirag B Patel, Bhavesh V Trikamji, Glenn E Mathisen, Shrikant K Mishra
Approximately 80% of individuals infected with West Nile virus (WNV) are asymptomatic, and less than 1% suffer from neuroinvasion that can result in permanent neurological deficits or mortality. Our institution's location in southern California predisposes it to a sizable case volume of neuroinvasive WNV. A 2-year retrospective study was performed at the Olive View-UCLA Medical Center to identify patients with confirmed WNV infection with neuroinvasion. Patient demographics, neurological exam findings, and laboratory diagnostics were reviewed...
November 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29117567/the-host-protein-reticulon-3-1a-is-utilized-by-flaviviruses-to-facilitate-membrane-remodelling
#8
Turgut E Aktepe, Susann Liebscher, Julia E Prier, Cameron P Simmons, Jason M Mackenzie
Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication. In this study, we identified a key role for the membrane-bending host protein Reticulon 3.1 (RTN3.1A) during the replication cycle of three flaviviruses: West Nile virus (WNV), Dengue virus (DENV), and Zika virus (ZIKV). We observed that, during infection, RTN3.1A is redistributed and recruited to the viral replication complex, a recruitment facilitated via the WNV NS4A protein, however, not DENV or ZIKV NS4A...
November 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/29117195/biological-and-phylogenetic-characteristics-of-west-african-lineages-of-west-nile-virus
#9
Gamou Fall, Nicholas Di Paola, Martin Faye, Moussa Dia, Caio César de Melo Freire, Cheikh Loucoubar, Paolo Marinho de Andrade Zanotto, Ousmane Faye, Amadou Alpha Sall
The West Nile virus (WNV), isolated in 1937, is an arbovirus (arthropod-borne virus) that infects thousands of people each year. Despite its burden on global health, little is known about the virus' biological and evolutionary dynamics. As several lineages are endemic in West Africa, we obtained the complete polyprotein sequence from three isolates from the early 1990s, each representing a different lineage. We then investigated differences in growth behavior and pathogenicity for four distinct West African lineages in arthropod (Ap61) and primate (Vero) cell lines, and in mice...
November 8, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29116220/vector-competence-of-european-mosquitoes-for-west-nile-virus
#10
REVIEW
Chantal Bf Vogels, Giel P Göertz, Gorben P Pijlman, Constantianus Jm Koenraadt
West Nile virus (WNV) is an arthropod-borne flavivirus of high medical and veterinary importance. The main vectors for WNV are mosquito species of the Culex genus that transmit WNV among birds, and occasionally to humans and horses, which are 'dead-end' hosts. Recently, several studies have been published that aimed to identify the mosquito species that serve as vectors for WNV in Europe. These studies provide insight in factors that can influence vector competence of European mosquito species for WNV. Here, we review the current knowledge on vector competence of European mosquitoes for WNV, and the molecular knowledge on physical barriers, anti-viral pathways and microbes that influence vector competence based on studies with other flaviviruses...
November 8, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29109710/aedes-aegypti-molecular-responses-to-zika-virus-modulation-of-infection-by-the-toll-and-jak-stat-immune-pathways-and-virus-host-factors
#11
Yesseinia I Angleró-Rodríguez, Hannah J MacLeod, Seokyoung Kang, Jenny S Carlson, Natapong Jupatanakul, George Dimopoulos
Zika (ZIKV) and dengue virus (DENV) are transmitted to humans by Aedes mosquitoes. However, the molecular interactions between the vector and ZIKV remain largely unexplored. In this work, we further investigated the tropism of ZIKV in two different Aedes aegypti strains and show that the virus infection kinetics, tissue migration, and susceptibility to infection differ between mosquito strains. We also compare the vector transcriptome changes upon ZIKV or DENV infection demonstrating that 40% of the mosquito's midgut infection-responsive transcriptome is virus-specific at 7 days after virus ingestion...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29103095/the-thermophilic-mosquito-species-uranotaenia-unguiculata-edwards-1913-diptera-culicidae-moves-north-in-germany
#12
Lisa Tippelt, Doreen Walther, Helge Kampen
Uranotaenia unguiculata is a thermophilic mosquito species frequently occurring in the Mediterranean. Its first detection in the southern German Upper Rhine Valley in 1994 represented its northernmost distribution limit for a long time. During recent mosquito monitoring activities, two specimens of the species were trapped at different localities, about 70 km apart, in northeastern Germany, some 300-km latitude north of previous collection sites. It is not known whether Ur. unguiculata is vector-competent for disease agents although specimens collected in the field were found infected with West Nile virus and Dirofilaria repens...
November 4, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29099073/helicase-domain-of-west-nile-virus-ns3-protein-plays-a-role-in-inhibition-of-type-i-interferon-signalling
#13
Yin Xiang Setoh, Parthiban Periasamy, Nias Yong Gao Peng, Alberto A Amarilla, Andrii Slonchak, Alexander A Khromykh
West Nile virus (WNV) is a neurotropic flavivirus that can cause encephalitis in mammalian and avian hosts. In America, the virulent WNV strain (NY99) is causing yearly outbreaks of encephalitis in humans and horses, while in Australia the less virulent Kunjin strain of WNV strain has not been associated with significant disease outbreaks until a recent 2011 large outbreak in horses (but not in humans) caused by NSW2011 strain. Using chimeric viruses between NY99 and NSW2011 strains we previously identified a role for the non-structural proteins of NY99 strain and especially the NS3 protein, in enhanced virus replication in type I interferon response-competent cells and increased virulence in mice...
November 2, 2017: Viruses
https://www.readbyqxmd.com/read/29098490/avian-viral-pathogens-in-swallows-zimbabwe-infectious-diseases-in-hirundinidae-a-risk-to-swallow
#14
A Caron, N Chiweshe, J Mundava, C Abolnik, A Capobianco Dondona, M Scacchia, N Gaidet
We sampled 417 swallows in a wetland ecosystem of Zimbabwe in February 2010 and October 2011. RT-PCR tests revealed circulation of avian paramyxovirus type I, avian influenza and West Nile disease viruses in these populations. We discuss the relevance of these findings in relation to what is known on the epidemiology of these viruses in these hosts and in relation to the host ecology. We conclude with recommendations to focus more research on Passeriformes in disease ecology and in particular on the hirundinidae family...
November 2, 2017: EcoHealth
https://www.readbyqxmd.com/read/29084217/wolbachia-effects-on-rift-valley-fever-virus-infection-in-culex-tarsalis-mosquitoes
#15
Brittany L Dodson, Elizabeth S Andrews, Michael J Turell, Jason L Rasgon
Innovative tools are needed to alleviate the burden of mosquito-borne diseases, and strategies that target the pathogen are being considered. A possible tactic is the use of Wolbachia, a maternally inherited, endosymbiotic bacterium that can (but does not always) suppress diverse pathogens when introduced to naive mosquito species. We investigated effects of somatic Wolbachia (strain wAlbB) infection on Rift Valley fever virus (RVFV) in Culex tarsalis mosquitoes. When compared to Wolbachia-uninfected mosquitoes, there was no significant effect of Wolbachia infection on RVFV infection, dissemination, or transmission frequencies, nor on viral body or saliva titers...
October 30, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29083957/differential-diagnosis-of-flavivirus-infections-in-horses-using-viral-envelope-protein-domain-iii-antigens-in-enzyme-linked-immunosorbent-assay
#16
Thisun B H Piyasena, Yin X Setoh, Jody Hobson-Peters, Natalie A Prow, Helle Bielefeldt-Ohmann, Alexander A Khromykh, David Perera, Mary J Cardosa, Peter D Kirkland, Roy A Hall
In Australia, infection of horses with the West Nile virus (WNV) or Murray Valley encephalitis virus (MVEV) occasionally results in severe neurological disease that cannot be clinically differentiated. Confirmatory serological tests to detect antibody specific for MVEV or WNV in horses are often hampered by cross-reactive antibodies induced to conserved epitopes on the envelope (E) protein. This study utilized bacterially expressed recombinant antigens derived from domain III of the E protein (rE-DIII) of MVEV and WNV, respectively, to determine whether these subunit antigens provided specific diagnostic markers of infection with these two viruses...
October 30, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29082585/vector-competence-of-field-populations-of-the-mosquito-species-aedes-japonicus-japonicus-and-culex-pipiens-from-switzerland-for-two-west-nile-virus-strains
#17
S Wagner, A Mathis, A C Schönenberger, S Becker, J Schmidt-Chanasit, C Silaghi, E Veronesi
Aedes (Hulecoeteomyia) japonicus japonicus (Diptera: Culicidae) (Theobald) is an invasive mosquito species in Central Europe, where it has colonized several areas. In this study, field-collected specimens of Ae. japonicus and Culex pipiens (Diptera: Culicidae) (Linnaeus) from Zürich (Switzerland) were orally exposed to two strains (NY99 and FIN) of the avian zoonotic pathogen West Nile virus (WNV) (family Flaviviridae, genus Flavivirus). Dissemination and transmission of the viruses after incubation for 12-15 days under a fluctuating Central European midsummer temperature regime (24 ± 7 °C) was investigated by detection of viral RNA in homogenates of pools of both head/thorax and saliva by reverse transcription real-time polymerase chain reaction (PCR)...
October 30, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29075656/rearing-of-culex-spp-and-aedes-spp-mosquitoes
#18
Elizabeth Kauffman, Anne Payne, Mary A Franke, Michael A Schmid, Eva Harris, Laura D Kramer
Mosquito-transmitted pathogens cause major public health problems and contribute substantially to the global burden of disease. Aedes mosquitoes transmit dengue, Zika, yellow fever, and Chikungunya viruses; Culex mosquitoes transmit West Nile, Japanese encephalitis, and Saint Louis encephalitis viruses, among others. Experiments utilizing laboratory-reared colonized mosquitoes can address many issues such as vector biology, vector competence, vector-pathogen interaction, and vector control. The establishment of healthy and standardized mosquito colonies requires generation and implementation of protocols, attention to detail, and an understanding of the factors that affect mosquito fitness, such as temperature and humidity, nutrient quality and availability, population density, blood feeding and mating behavior, and egg-laying requirements...
September 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29074649/complete-genome-sequence-of-west-nile-virus-wnv-from-the-first-human-case-of-neuroinvasive-wnv-infection-in-cyprus
#19
Jan Richter, Christina Tryfonos, Aristomenis Tourvas, Dora Floridou, Niki I Paphitou, Christina Christodoulou
We report here the complete genome sequence of a West Nile virus (WNV) strain from the first laboratory-confirmed human case of neuroinvasive WNV infection in Cyprus. Phylogenetic analysis showed that this WNV strain grouped clearly into genetic lineage 1, clade 1a, cluster 2.
October 26, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29074234/development-of-a-rapid-and-quantitative-method-for-the-analysis-of-viral-entry-and-release-using-a-nanoluc-luciferase-complementation-assay
#20
Michihito Sasaki, Paulina D Anindita, Wallaya Phongphaew, Michael Carr, Shintaro Kobayashi, Yasuko Orba, Hirofumi Sawa
Subviral particles (SVPs) self-assemble and are released from cells transfected with expression plasmids encoding flavivirus structural proteins. Flavivirus-like particles (VLPs), consisting of flavivirus structural proteins and a subgenomic replicon, can enter cells and cause single-round infections. Neither SVPs or VLPs possess complete viral RNA genomes, therefore are replication-incompetent systems; however, they retain the capacity to fuse and bud from target cells and follow the same maturation process as whole virions...
October 23, 2017: Virus Research
keyword
keyword
110783
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"