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https://www.readbyqxmd.com/read/29649965/evaluation-of-the-influence-of-sprinkling-powdered-slaked-lime-on-microorganisms-for-the-prevention-of-domestic-animal-infectious-diseases
#1
Miho Mori, Yoshikazu Sakagami, Yousuke Hamazaki, Toru Jojima
When infectious diseases arise in domestic animals, a large amount of slaked lime is sprinkled on cattle sheds and their surroundings for disinfection and prevention. However, optimal sprinkling methods, standard and upper limit of slaked lime, and influence of slaked lime on non-target microorganisms remain unclear. In this study, we clarified detailed microbicidal effects of slaked lime via in vitro experiments and the influence of sprinkling powdered slaked lime (PSL) in field soil on microorganisms. In vitro disinfection tests assessing the appropriate amount of water and ventilation conditions were also performed in sterilized glass bottles with soil and Salmonella enterica subsp...
April 13, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29643002/3d-printing-of-a-lithium-calcium-silicate-crystal-bioscaffold-with-dual-bioactivities-for-osteochondral-interface-reconstruction
#2
Lei Chen, Cuijun Deng, Jiayi Li, Qingqiang Yao, Jiang Chang, Liming Wang, Chengtie Wu
It is difficult to achieve self-healing outcoming for the osteochondral defects caused by degenerative diseases. The simultaneous regeneration of both cartilage and subchondral bone tissues is an effective therapeutic strategy for osteochondral defects. However, it is challenging to design a single type of bioscaffold with suitable ionic components and beneficial osteo/chondral-stimulation ability for regeneration of osteochondral defects. In this study, we successfully synthesized a pure-phase lithium calcium silicate (Li2 Ca4 Si4 O13 , L2 C4 S4 ) bioceramic by a sol-gel method, and further prepared L2 C4 S4 scaffolds by using a 3D-printing method...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29619293/in-vivo-photoacoustic-imaging-of-brain-injury-and-rehabilitation-by-high-efficient-near-infrared-dye-labeled-mesenchymal-stem-cells-with-enhanced-brain-barrier-permeability
#3
Weitao Li, Ronghe Chen, Jing Lv, Hongke Wang, Yu Liu, Ya Peng, Zhiyu Qian, Guo Fu, Liming Nie
Stem cell migration and interaction with pathology are critical to understand the complexity and status of disease recovery progress. However, the dynamic visualization still remains a great challenge due to imaging technical limitation, cell labeling difficulty, or blood-brain barrier (BBB). Herein, fast photoacoustic tomography (PAT) with optical molecular probes is applied to noninvasively monitor traumatic brain injury (TBI) and its rehabilitation. The vascular distribution and TBI hemorrhage are clearly imaged, longitudinally monitored, and quantified...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29614179/association-of-solid-fuel-use-with-risk-of-cardiovascular-and-all-cause-mortality-in-rural-china
#4
Kuai Yu, Gaokun Qiu, Ka-Hung Chan, Kin-Bong Hubert Lam, Om P Kurmi, Derrick A Bennett, Canqing Yu, An Pan, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Frank B Hu, Zhengming Chen, Liming Li, Tangchun Wu
Importance: When combusted indoors, solid fuels generate a large amount of pollutants such as fine particulate matter. Objective: To assess the associations of solid fuel use for cooking and heating with cardiovascular and all-cause mortality. Design, Setting, and Participants: This nationwide prospective cohort study recruited participants from 5 rural areas across China between June 2004 and July 2008; mortality follow-up was until January 1, 2014...
April 3, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29596515/primary-care-pediatricians-attitudes-and-practice-towards-hpv-vaccination-a-nationwide-survey-in-italy
#5
Francesco Napolitano, Monica Navaro, Luigi Vezzosi, Gabriella Santagati, Italo Francesco Angelillo
This national online cross-sectional survey in Italy assessed primary care pediatricians' (PCPs) attitudes and practices regarding Human papillomavirus (HPV) vaccination and the contribution of several characteristics. The questionnaire was distributed from September 2016 to June 2017 to a random sample of 640 PCPs by email via an internet-link leading to a web-based survey platform (Lime Survey). Only 18.4% of PCPs always recommend the HPV vaccine to 11-12 year old boys. PCPs with longer practice activity, working in solo practice, always recommended the HPV vaccine to 11-12 year old girls, and believed that the vaccine was effective for boys were more likely to always recommend the HPV vaccine...
2018: PloS One
https://www.readbyqxmd.com/read/29578003/abnormal-changes-in-voltage-gated-sodium-channels-subtypes-na-v-1-1-na-v-1-2-na-v-1-3-na-v-1-6-and-cam-camkii-pathway-in-low-grade-astrocytoma
#6
Gefei Guan, Mingyi Zhao, Xiaoxue Xu, Tomasz Boczek, Xiaoyuan Mao, Zhi Li, Qinghua Gao, Jianing Li, Dongyi Zhao, Wanting Niu, Liming Lei, Feng Guo
Epileptic seizures are the main clinical manifestation of low-grade astrocytoma. Voltage-gated sodium channels (VGSCs) play a crucial role in epilepsy. Until now, the role of VGSCs and the relationships between calmodulin (CaM)/CaM-dependent protein kinase II (CaMKII) and VGSCs in low-grade astrocytoma have not been demonstrated. In our study, the protein expression of NaV 1.3, NaV 1.6 and CaM was significantly increased in the tumor compared to control tissue, while the level of p-CaMKII/CaMKII was significantly decreased in the tumor group as determined by Western Blotting and immunohistochemistry...
March 22, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29573958/beta-2-microglobulin-and-the-severity-of-coronary-stenosis-in-patients-with-acute-coronary-syndrome
#7
Chenglong Zhang, Fengjuan Li, Tianyi Long, Fei Li, Liming Peng, Ke Xia, Ran Jing, Qiying Xie, Tianlun Yang
BACKGROUND: Previous studies have shown that beta 2-microglobulin (B2M) could predict all-cause mortality and cardiovascular mortality in various groups of people. However, the relationship between B2M and severity of coronary stenosis in patients with acute coronary syndrome has not been established. METHODS: We enrolled 872 consecutive patients admitted with acute coronary syndrome in our study. All participants underwent coronary angiography examination or stent implantation after admission...
March 5, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29566761/the-expression-profile-of-human-peripheral-blood-mononuclear-cell-mirna-is-altered-by-antibody-dependent-enhancement-of-infection-with-dengue-virus-serotype-3
#8
Liming Jiang, Qiangming Sun
BACKGROUND: Antibody-dependent enhancement (ADE) of dengue virus (DENV) infection has been identified as the main risk factor for severe dengue disease, although the underlying mechanisms leading to severe dengue fever remain unclear. MicroRNAs (miRNAs) participate in numerous pathological and biological processes, including host responses to viral infections. METHOD: Here, we aimed to investigate the differences in miRNA expression patterns in human peripheral blood mononuclear cells (PBMCs) infected with DENV-3 and DENV-3-ADE at various time points employing high-throughput sequencing...
March 22, 2018: Virology Journal
https://www.readbyqxmd.com/read/29563785/excess-risk-of-major-vascular-diseases-associated-with-airflow-obstruction-a-9-year-prospective-study-of-0-5-million-chinese-adults
#9
Om P Kurmi, Liming Li, Kourtney J Davis, Jenny Wang, Derrick A Bennett, Ka Hung Chan, Ling Yang, Yiping Chen, Yu Guo, Zheng Bian, Junshi Chen, Liuping Wei, Donghui Jin, Rory Collins, Richard Peto, Zhengming Chen
Background: China has high COPD rates, even among never-regular smokers. Little is known about nonrespiratory disease risks, especially vascular morbidity and mortality after developing airflow obstruction (AFO) in Chinese adults. Objective: We aimed to investigate the prospective association of prevalent AFO with major vascular morbidity and mortality. Materials and methods: In 2004-2008, a nationwide prospective cohort study recruited 512,891 men and women aged 30-79 years from 10 diverse localities across China, tracking cause-specific mortality and coded episodes of hospitalization for 9 years...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29551903/icotinib-hydrochloride-enhances-chemo-and-radiosensitivity-by-inhibiting-egfr-signaling-and-attenuating-rad51-expression-and-function-in-hela-s3-cells
#10
Xuanxuan Wang, Yanjun Gu, Hai Liu, Liming Shi, Xiaonan Sun
Background: Radiotherapy and cisplatin-based chemotherapy are currently considered as standard treatments employed for advanced cervical cancer (CC). However, patients with local recurrence or distant metastasis continue to have poor outcomes. EGFR overexpression correlated with chemo/radioresistance, and disease failure has been well proved in the previous studies. Hence, the aim of this study was to explore the therapeutic efficacy and underlying mechanism of the sensitization to radiation or cisplatin of icotinib hydrochloride (IH), a high-selective EGFR tyrosine kinase inhibitor (TKI), in the Hela S3 human CC cell line...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29543350/nanomaterials-in-neural-stem-cell-mediated-regenerative-medicine-imaging-and-treatment-of-neurological-diseases
#11
REVIEW
Bingbo Zhang, Wei Yan, Yanjing Zhu, Weitao Yang, Wenjun Le, Bingdi Chen, Rongrong Zhu, Liming Cheng
Patients are increasingly being diagnosed with neuropathic diseases, but are rarely cured because of the loss of neurons in damaged tissues. This situation creates an urgent clinical need to develop alternative treatment strategies for effective repair and regeneration of injured or diseased tissues. Neural stem cells (NSCs), highly pluripotent cells with the ability of self-renewal and potential for multidirectional differentiation, provide a promising solution to meet this demand. However, some serious challenges remaining to be addressed are the regulation of implanted NSCs, tracking their fate, monitoring their interaction with and responsiveness to the tissue environment, and evaluating their treatment efficacy...
March 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29531747/patterns-and-management-of-chronic-obstructive-pulmonary-disease-in-urban-and-rural-china-a-community-based-survey-of-25-000-adults-across-10-regions
#12
Om P Kurmi, Kourtney J Davis, Kin Bong Hubert Lam, Yu Guo, Julien Vaucher, Derrick Bennett, Jenny Wang, Zheng Bian, Huaidong Du, Liming Li, Robert Clarke, Zhengming Chen
Introduction: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, with COPD deaths in China accounting for one-third of all such deaths. However, there is limited available evidence on the management of COPD in China. Methods: A random sample of 25 011 participants in the China Kadoorie Biobank, aged 38-87 years, from 10 regions in China was surveyed in 2013-2014. Data were collected using interviewer-administered questionnaires on the diagnosis ('doctor-diagnosed' or 'symptoms-based') and management of COPD (including use of medication and other healthcare resources), awareness of diagnosis and severity of symptoms in COPD cases...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29530372/characteristics-and-correlates-of-sleep-duration-daytime-napping-snoring-and-insomnia-symptoms-among-0-5-million-chinese-men-and-women
#13
Yiping Chen, Christiana Kartsonaki, Robert Clarke, Yu Guo, Canqing Yu, Zheng Bian, Qilian Jiang, Shanpeng Li, Junshi Chen, Liming Li, Zhengming Chen
BACKGROUND: Inadequate sleep duration and insomnia can affect both physical and mental health. There is limited evidence, however, on characteristics and correlates of sleep patterns and insomnia in urban and rural China. METHODS: This cross-sectional study, involving 512,891 adults aged 30-79 years from ten (five urban and five rural) diverse areas in China, recorded detailed information, using interviewer-administered laptop-based questionnaires, on sleep patterns (duration, daytime napping and snoring) and insomnia symptoms...
April 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29527419/genetic-analysis-of-candidatus-phytoplasma-aurantifolia-associated-with-witches-broom-on-acid-lime-trees
#14
Aisha G Al-Ghaithi, Ali M Al-Subhi, Issa H Al-Mahmooli, Abdullah M Al-Sadi
" Candidatus Phytoplasma aurantifolia" is associated with witches' broom disease of lime in Oman and the UAE. A previous study showed that an infection by phytoplasma may not necessarily result in the physical appearance of witches' broom symptoms in some locations in Oman and the UAE. This study investigated whether phytoplasma strains belonging to " Ca. P. aurantifolia" (based on the 16S rRNA gene analysis) in locations where disease symptoms are expressed are different from phytoplasma in locations where disease symptoms are not expressed...
2018: PeerJ
https://www.readbyqxmd.com/read/29525237/comparison-of-cortical-responses-to-the-activation-of-retina-by-visual-stimulation-and-transcorneal-electrical-stimulation
#15
Pengcheng Sun, Heng Li, Zhuofan Lu, Xiaofan Su, Zengguang Ma, Jianpin Chen, Liming Li, Chuanqing Zhou, Yao Chen, Xinyu Chai
BACKGROUND: Electrical stimulation has been widely used in many ophthalmic diseases to modulate neuronal activities or restore partial visual function. Due to the different processing pathways and mechanisms, responses to visual and electrical stimulation in the primary visual cortex and higher visual areas might be different. This differences would shed some light on the properties of cortical responses evoked by electrical stimulation. OBJECTIVE: This study's goal was to directly compare the cortical responses evoked by visual and electrical stimulation and investigate the cortical processing of visual information and extrinsic electrical signal...
February 21, 2018: Brain Stimulation
https://www.readbyqxmd.com/read/29524883/halofuginone-attenuates-intervertebral-discs-degeneration-by-suppressing-collagen-i-production-and-inactivating-tgf%C3%AE-and-nf-%C3%B0%C2%BAb-pathway
#16
Linghui Luo, Yong Gao, Cao Yang, Zengwu Shao, Xinghuo Wu, Shuai Li, Liming Xiong, Chao Chen
Most low back pain is caused by intervertebral discs (IVD) degeneration, a disease that prevalence is increasing with age. Halofuginone, an analog of ferbrifugine isolated from plant Dichroa febrifuga, has drawn much attention in recent years for the wide range of bioactivities in malaria, cancer, fibrotic and autoimmune diseases. In this study, we evaluated the benefit effects of halofuginone in IVD degeneration treatment in a validated rabbit puncture model. Halofuginone treatment could attenuate disc degeneration by suppressing the decrease of discs height and nucleus pulposus signal strength...
March 7, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29522945/association-between-major-depressive-episode-and-risk-of-type-2-diabetes-a-large-prospective-cohort-study-in-chinese-adults
#17
Ruiwei Meng, Na Liu, Canqing Yu, Xiongfei Pan, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
OBJECTIVE: We aimed to prospectively evaluate the association between major depressive episode (MDE) and risk of type 2 diabetes in a Chinese population. METHODS: We used data from the China Kadoorie Biobank study, in which 461,213 participants free of diabetes, coronary heart disease, stroke, and cancer were followed from baseline (2004-2008) to December 31, 2013. A modified Chinese version of Composite International Diagnostic Interview Short-Form (CIDI-SF) was used to assess past year MDE...
February 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29509243/targeting-histone-deacetylases-in-endometrial-cancer-a-paradigm-shifting-therapeutic-strategy
#18
N Garmpis, C Damaskos, A Garmpi, E Spartalis, E Kalampokas, T Kalampokas, G-A Margonis, D Schizas, N Andreatos, A Angelou, A Lavaris, A Athanasiou, K G Apostolou, M Spartalis, Z Damaskou, A Daskalopoulou, E Diamantis, K Tsivelekas, A Alavanos, S Valsami, M M Moschos, A Sampani, A Nonni, E A Antoniou, D Mantas, G Tsourouflis, K Markatos, K Kontzoglou, D Perrea, N Nikiteas, A Kostakis, D Dimitroulis
OBJECTIVE: Endometrial cancer is increasingly prevalent in western societies and affects mainly postmenopausal women; notably incidence rates have been rising by 1.9% per year on average since 2005. Although the early-stage endometrial cancer can be effectively managed with surgery, more advanced stages of the disease require multimodality treatment with varying results. In recent years, endometrial cancer has been extensively studied at the molecular level in an attempt to develop effective therapies...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29477475/nepetin-inhibits-il-1%C3%AE-induced-inflammation-via-nf-%C3%AE%C2%BAb-and-mapks-signaling-pathways-in-arpe-19-cells
#19
Xi Chen, Ruifang Han, Peng Hao, Liming Wang, Meixin Liu, Meihua Jin, Dexin Kong, Xuan Li
BACKGROUNDS: Chronic inflammation in retinal pigment epithelial (RPE) cells is related to the pathogenesis of retinal inflammatory blind causing diseases such as age-related macular degeneration (AMD) and diabetic retinopathy (DR). Nepetin, a natural flavonoid compound, has shown potent anti-inflammatory activities but has not been studied on ocular resident cells yet. Here, we assess the ability of Nepetin to alleviate the inflammatory responses of ARPE-19 cells induced by interleukin (IL)-1β...
February 22, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29477076/secretase-inhibitors-for-the-treatment-of-alzheimer-s-disease-long-road-ahead
#20
REVIEW
Devendra Kumar, Ankit Ganeshpurkar, Dileep Kumar, Gyan Modi, Sanjeev Kumar Gupta, Sushil Kumar Singh
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by progressive loss of memory which is associated with other cognitive deficits. The two protein structures in the brain i.e. neurofibrillary tangles and senile plaques are considered to hamper the normal cognitive activity of the brain. There are various therapeutic interpolations under investigation to thwart and treat AD. Secretases inhibitors are important agents that inhibit the development of senile plaques. β-secretase (BACE) inhibitors are in lime light for the drug development of AD...
February 15, 2018: European Journal of Medicinal Chemistry
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