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https://www.readbyqxmd.com/read/29216461/associations-of-environmental-exposure-to-metals-with-the-risk-of-hypertension-in-china
#1
Weixiang Wu, Shunli Jiang, Qiang Zhao, Ke Zhang, Xiaoyun Wei, Tong Zhou, Dayang Liu, Hao Zhou, Rong Zhong, Qiang Zeng, Liming Cheng, Xiaoping Miao, Qing Lu
Hypertension contributes largely to the global burden of disease and mortality. Environmental exposure to metals might be a causative factor for hypertension, but the association remains unclear. The present case-control study of 502 hypertension patients and 502 healthy participants aimed to evaluate the potential relationships between the concentrations of 20 metal in urine and the risk of hypertension in a Chinese population. Multivariate logistic analyses adjusted for potential confounders were performed separately considering the effects of single and multi-metal...
December 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29161448/prenatal-famine-exposure-adulthood-obesity-patterns-and-risk-of-type-2-diabetes
#2
Ruogu Meng, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hui Zhang, Xiaofang Chen, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Background: Prenatal exposure to famine and adulthood obesity have been independently related to the risk of type 2 diabetes; however, little is known about the joint effects of these risk factors at different stages of life on adulthood diabetes risk. Methods: The analysis included 88 830 participants of the China Kadoorie Biobank, who were born around the time of the Chinese Great Famine and without diabetes, cardiovascular diseases, or cancer at baseline. We defined famine exposure subgroups as nonexposed (born between 1 October 1962 and 30 September 964), fetal-exposed (born between 1 October 1959 and 30 September 1961) and early-childhood exposed (born between 1 October 1956 and 30 September 1958)...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29160060/phase-transition-nanoparticles-as-multimodality-contrast-agents-for-the-detection-of-thrombi-and-targeting-thrombolysis-in-vitro-and-in-vivo-experiments
#3
Jie Xu, Jun Zhou, Yixin Zhong, Yu Zhang, Jia Liu, Yuli Chen, Liming Deng, Danli Sheng, Zhigang Wang, Haitao Ran, Dajing Guo
Thrombotic disease is extremely harmful to human health, and early detection and treatment can improve the prognosis and reduce mortality. Multimodal molecular imaging can provide abundant information about thrombi, but to date, few studies have used multimodal and multifunctional nanoparticles (NPs) for thrombus detection and targeting thrombolysis. In this study, phase transition multimodal and multifunctional NPs (EWVDV-Fe-Ink-PFH NPs) were constructed for the first time using a three-step emulsification and carbodiimide method, and the physical and chemical properties of the NPs were investigated...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29158491/gallstone-disease-and-the-risk-of-type-2-diabetes
#4
Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Shanpeng Li, Yuelong Huang, Yan Fu, Pan He, Aiyu Tang, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Gallstone disease (GSD) is related to several diabetes risk factors. The present study was to examine whether GSD was independently associated with type 2 diabetes in the China Kadoorie Biobank study. After excluding participants with prevalent diabetes and prior histories of cancer, heart disease, and stroke at baseline, 189,154 men and 272,059 women aged 30-79 years were eligible for analysis. The baseline prevalence of GSD was 5.7% of the included participants. During 4,138,687 person-years of follow-up (median, 9...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29157240/automatic-diagnosis-of-imbalanced-ophthalmic-images-using-a-cost-sensitive-deep-convolutional-neural-network
#5
Jiewei Jiang, Xiyang Liu, Kai Zhang, Erping Long, Liming Wang, Wangting Li, Lin Liu, Shuai Wang, Mingmin Zhu, Jiangtao Cui, Zhenzhen Liu, Zhuoling Lin, Xiaoyan Li, Jingjing Chen, Qianzhong Cao, Jing Li, Xiaohang Wu, Dongni Wang, Jinghui Wang, Haotian Lin
BACKGROUND: Ocular images play an essential role in ophthalmological diagnoses. Having an imbalanced dataset is an inevitable issue in automated ocular diseases diagnosis; the scarcity of positive samples always tends to result in the misdiagnosis of severe patients during the classification task. Exploring an effective computer-aided diagnostic method to deal with imbalanced ophthalmological dataset is crucial. METHODS: In this paper, we develop an effective cost-sensitive deep residual convolutional neural network (CS-ResCNN) classifier to diagnose ophthalmic diseases using retro-illumination images...
November 21, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29152064/development-of-a-population-based-cancer-case-control-study-in-southern-china
#6
Weimin Ye, Ellen T Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L Vaughan, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Hans-Olov Adami
With its population of over 1.3 billion persons, China offers abundant opportunities to discover causes of disease. However, few rigorous population-based case-control studies have as yet been conducted in mainland China. We conducted a population-based case-control study of nasopharyngeal carcinoma in Guangdong Province and Guangxi Autonomous Region. We collected questionnaires and biospecimens from incident cases recruited between March 2010 and December 2013, and population-based controls between November 2010 and November 2014...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29146190/newly-developed-selective-immunoinactivation-assay-revealed-reduction-in-adipose-triglyceride-lipase-activity-in-peripheral-leucocytes-from-patients-with-idiopathic-triglyceride-deposit-cardiomyovasculopathy
#7
Atsuko Takagi, Yasuyuki Ikeda, Kunihisa Kobayashi, Kazuhiro Kobayashi, Yoshihiko Ikeda, Junji Kozawa, Hideyuki Miyauchi, Ming Li, Chikako Hashimoto, Yasuhiro Hara, Satoshi Yamaguchi, Akira Suzuki, Tatsushi Toda, Hironori Nagasaka, Ken-Ichi Hirano
Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare and newly identified disease among patients requiring cardiac transplantation. TGCV is characterized by cardiomyocyte steatosis and triglyceride (TG)-deposit atherosclerosis, resulting from the abnormal intracellular metabolism of TG. TGCV is classified into primary and idiopathic types. Primary TGCV carries ultra-rare genetic mutations in the adipose triglyceride lipase (ATGL), a rate-liming enzyme that hydrolyzes intracellular TG in adipose and non-adipose tissues...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29141072/association-of-cetp-gene-variants-with-risk-for-vascular-and-nonvascular-diseases-among-chinese-adults
#8
Iona Y Millwood, Derrick A Bennett, Michael V Holmes, Ruth Boxall, Yu Guo, Zheng Bian, Ling Yang, Sam Sansome, Yiping Chen, Huaidong Du, Canqing Yu, Alex Hacker, Dermot F Reilly, Yunlong Tan, Michael R Hill, Junshi Chen, Richard Peto, Hongbing Shen, Rory Collins, Robert Clarke, Liming Li, Robin G Walters, Zhengming Chen
Importance: Increasing levels of high-density lipoprotein (HDL) cholesterol through pharmacologic inhibition of cholesteryl ester transfer protein (CETP) is a potentially important strategy for prevention and treatment of cardiovascular disease (CVD). Objective: To use genetic variants in the CETP gene to assess potential risks and benefits of lifelong lower CETP activity on CVD and other outcomes. Design, Setting, and Participants: This prospective biobank study included 151 217 individuals aged 30 to 79 years who were enrolled from 5 urban and 5 rural areas of China from June 25, 2004, through July 15, 2008...
November 15, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29140972/long-noncoding-rna-profiling-revealed-differentially-expressed-lncrnas-associated-with-disease-activity-in-pbmcs-from-patients-with-rheumatoid-arthritis
#9
Min Yuan, Shujun Wang, Lijie Yu, Bo Qu, Liming Xu, Lining Liu, Huanxia Sun, Chunxian Li, Yanjun Shi, Huaxiang Liu
Long noncoding RNAs (lncRNAs) have recently emerged as important biological regulators, and the aberrant expression of lncRNAs has been reported in numerous diseases. However, the expression of lncRNAs in peripheral blood mononuclear cells (PBMCs) in rheumatoid arthritis (RA) has not been well documented. We applied a microarray analysis to profile the lncRNA and mRNA expression in 3 pairs of samples. Each sample was mixed with equivalent PBMCs from 9 female RA patients and 9 corresponding healthy controls, and the data were validated via qPCR using another cohort that comprised 36 RA patients and 24 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/29133030/20-s-protopanaxadiol-ppd-alleviates-scopolamine-induced-memory-impairment-via-regulation-of-cholinergic-and-antioxidant-systems-and-expression-of-egr-1-c-fos-and-c-jun-in-mice
#10
Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects and exhibited strong antidepressant-like effects in vivo. The objective of the present study was first to investigate the effect of PPD in scopolamine (SCOP)-induced memory deficit in mice and the potential mechanisms involved...
November 10, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29120959/effect-of-total-domain-specific-and-intensity-specific-physical-activity-on-all-cause-and-cardiovascular-mortality-among-hypertensive-adults-in-china
#11
Mengyu Fan, Canqing Yu, Yu Guo, Zheng Bian, Xia Li, Ling Yang, Yiping Chen, Mingqiang Li, Xianzhi Li, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
OBJECTIVES: We aimed to prospectively examine the associations of total, domain-specific, and intensity-specific physical activity with all-cause and cardiovascular mortality among Chinese hypertensive adults. METHODS: We performed a prospective cohort study in 150 391 hypertensive participants aged 30-79 years from the China Kadoorie Biobank study of 512 891 participants recruited from 10 diverse areas across China during 2004-2008. Participants with heart disease, stroke, chronic obstructive pulmonary disease, and cancer at baseline were excluded...
November 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29120831/epidemiology-of-areca-betel-nut-use-in-the-mariana-islands-findings-from-the-university-of-guam-university-of-hawai-i-cancer-center-partnership-program
#12
Yvette C Paulino, Eric L Hurwitz, Joanne C Ogo, Tristan C Paulino, Ashley B Yamanaka, Rachel Novotny, Lynne R Wilkens, Mary Jane Miller, Neal A Palafox
BACKGROUND: Areca (betel) nut is considered a Group 1 human carcinogen shown to be associated with other chronic diseases in addition to cancer. This paper describes the areca (betel) nut chewing trend in Guam, and health behaviors of chewers in Guam and Saipan. METHODS: The areca (betel) nut module in the Guam Behavioral Risk Factor Surveillance Survey was used to calculate the 5-year (2011-2015) chewing trend. To assess the association between areca (betel) nut chewing and health risks in the Mariana Islands, a cross-section of 300 chewers, ≥18years old, were recruited from households in Guam and Saipan...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29117982/menopause-characteristics-total-reproductive-years-and-risk-of-cardiovascular-disease-among-chinese-women
#13
Ling Yang, Liling Lin, Christiana Kartsonaki, Yu Guo, Yiping Chen, Zheng Bian, Kaixu Xie, Donghui Jin, Liming Li, Jun Lv, Zhengming Chen
BACKGROUND: Previous studies, mostly of Western women, have reported inconsistent findings on the association of menopause characteristics (status, age, and time since menopause) and total reproductive years with risk of cardiovascular disease (CVD). METHODS AND RESULTS: The China Kadoorie Biobank recruited 302 632 women in 2004 to 2008 from 10 regions across China. During 9-year follow-up, 19 393 incident cases of stroke, 18 611 of ischemic heart disease, and 4978 CVD deaths occurred...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29117341/association-of-physical-activity-with-risk-of-major-cardiovascular-diseases-in-chinese-men-and-women
#14
Derrick A Bennett, Huaidong Du, Robert Clarke, Yu Guo, Ling Yang, Zheng Bian, Yiping Chen, Iona Millwood, Canqing Yu, Pan He, Xiangyang Zheng, Rory Collins, Junshi Chen, Richard Peto, Liming Li, Zhengming Chen
Importance: In China, the patterns and levels of physical activity differed from those in high-income countries. Substantial uncertainty remains about the relevance, both qualitatively and quantitatively, of domain-specific physical activity for cardiovascular disease (CVD) subtypes in Chinese adults. Objective: To assess the shape and strength of the associations of total, occupational, and nonoccupational physical activity with CVD subtypes in Chinese men and women...
November 8, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29113417/porphyrin-photosensitizers-in-photodynamic-therapy-and-its-applications
#15
REVIEW
Jiayuan Kou, Dou Dou, Liming Yang
In 1841, the extraction of hematoporphyrin from dried blood by removing iron marked the birth of the photosensitizer. The last twenty years has witnessed extensive research in the application of photodynamic therapy (PDT) in tumor-bearing (or other diseases) animal models and patients. The period has seen development of photosensitizers from the first to the third generation, and their evolution from simple to more complex entities. This review focuses on porphyrin photosensitizers and their effect on tumors, mediated via several pathways involved in cell necrosis, apoptosis or autophagic cell death, and the preventive and therapeutic application of PDT against atherosclerosis...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105297/recent-advances-in-understanding-xanthomonas-citri-subsp-citri-pathogenesis-and-citrus-canker-disease-management
#16
Christopher M Ference, Alberto M Gochez, Franklin Behlau, Nian Wang, James H Graham, Jeffrey B Jones
Taxonomic status: Bacteria; Phylum Proteobacteria; Class Gammaproteobacteria; Order Xanthomonadles; Family Xanthomonadaceae; Genus Xanthomonas; Species Xanthomonas citri subsp. citri (Xcc). Host range: Compatible hosts vary in their susceptibility to CC, with grapefruit, lime, and lemon being most susceptible, sweet orange being moderately susceptible, and kumquat and calamondin being among the least susceptible (Gottwald et al., 1993). Microbiological properties: Xcc is a rod-shaped (1.5 - 2.0 X 0.5 - 0.75 µm) gram-negative, aerobic bacterium with a single polar flagellum...
November 4, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29103604/incidence-predictors-and-mortality-of-infective-endocarditis-in-adults-with-congenital-heart-disease-without-prosthetic-valves
#17
Darren Mylotte, Dinela Rushani, Judith Therrien, Liming Guo, Aihua Liu, Kenneth Guo, Giuseppe Martucci, Andrew S Mackie, Jay S Kaufman, Ariane Marelli
Congenital heart disease (CHD) increases the risk of infective endocarditis (IE), though the lesion-specific risk and mortality are poorly defined. Using the population-based Quebec CHD database, we sought to describe the predictors of IE and to evaluate if IE was associated with mortality among adult CHD (ACHD) patients without prior valve replacement surgery. We extracted data on ACHD patients with IE and assessed the lesion-specific incidence of IE, risk factors for IE acquisition, and all-cause 1-year mortality...
October 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29097680/epigenome-wide-association-studies-identify-dna-methylation-associated-with-kidney-function
#18
Audrey Y Chu, Adrienne Tin, Pascal Schlosser, Yi-An Ko, Chengxiang Qiu, Chen Yao, Roby Joehanes, Morgan E Grams, Liming Liang, Caroline A Gluck, Chunyu Liu, Josef Coresh, Shih-Jen Hwang, Daniel Levy, Eric Boerwinkle, James S Pankow, Qiong Yang, Myriam Fornage, Caroline S Fox, Katalin Susztak, Anna Köttgen
Chronic kidney disease (CKD) is defined by reduced estimated glomerular filtration rate (eGFR). Previous genetic studies have implicated regulatory mechanisms contributing to CKD. Here we present epigenome-wide association studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham Heart Study participants to identify epigenetic signatures of kidney function. Of 19 CpG sites significantly associated (P < 1e-07) with eGFR/CKD and replicated, five also associate with renal fibrosis in biopsies from CKD patients and show concordant DNA methylation changes in kidney cortex...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29080862/plasma-metabolites-from-choline-pathway-and-risk-of-cardiovascular-disease-in-the-predimed-prevention-with-mediterranean-diet-study
#19
Marta Guasch-Ferré, Frank B Hu, Miguel Ruiz-Canela, Mònica Bulló, Estefanía Toledo, Dong D Wang, Dolores Corella, Enrique Gómez-Gracia, Miquel Fiol, Ramon Estruch, José Lapetra, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Emilio Ros, Courtney Dennis, Liming Liang, Clary B Clish, Miguel A Martínez-González, Jordi Salas-Salvadó
BACKGROUND: The relationship between plasma concentrations of betaine and choline metabolism and major cardiovascular disease (CVD) end points remains unclear. We have evaluated the association between metabolites from the choline pathway and risk of incident CVD and the potential modifying effect of Mediterranean diet interventions. METHODS AND RESULTS: We designed a case-cohort study nested within the PREDIMED (Prevention With Mediterranean Diet) trial, including 229 incident CVD cases and 751 randomly selected participants at baseline, followed up for 4...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29066119/concurrent-chemoradiotherapy-in-curatively-resected-gallbladder-carcinoma-a-propensity-score-matched-analysis
#20
Benxing Gu, Liwen Qian, Hong Yu, Jianbin Hu, Qi Wang, Jingjing Shan, Liming Shi, Hai Liu, Qichu Yang, Xiao Liang, Xiujun Cai, Xiaonan Sun
PURPOSE: To compare overall survival (OS) between patients receiving radical resection followed by concurrent chemoradiotherapy (S+CCRT) and patients receiving radical resection only (S) for advanced resectable gallbladder carcinoma (GBC). METHODS AND MATERIALS: Ninety-four GBC patients with stage pT2-4, N0-1, and M0 consented to inclusion in a clinical database from June 2003 to July 2013. Patients who received S+CCRT were matched by propensity score with those who received S through nearest-neighbor matching, with a caliper width of 0...
September 20, 2017: International Journal of Radiation Oncology, Biology, Physics
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