keyword
https://read.qxmd.com/read/33679443/human-red-blood-cells-modulate-cytokine-expression-in-monocytes-macrophages-under-anoxic-conditions
#21
JOURNAL ARTICLE
Antonella Antonelli, Emanuele Salvatore Scarpa, Mauro Magnani
In the bone marrow (BM) hematopoietic niche, the oxygen tension is usually very low. Such condition affects stem and progenitor cell proliferation and differentiation and, at cellular level regulates hematopoietic growth factors, chemokines and adhesion molecules expression. In turn, these molecules affect the proliferation and maturation of other cellular components of the niche. Due to the complexity of the system we started the in vitro investigations of the IL-6, IL-8, TNFα cytokines expression and the vascular endothelial growth factor (VEGF), considered key mediators of the hematopoietic niche, in human macrophages and macrophage cell line...
2021: Frontiers in Physiology
https://read.qxmd.com/read/33671100/comparison-of-the-efficacy-of-two-novel-antitubercular-agents-in-free-and-liposome-encapsulated-formulations
#22
JOURNAL ARTICLE
Nikoletta Kósa, Ádám Zolcsák, István Voszka, Gabriella Csík, Kata Horváti, Lilla Horváth, Szilvia Bősze, Levente Herenyi
Tuberculosis is one of the top ten causes of death worldwide, and due to the appearance of drug-resistant strains, the development of new antituberculotic agents is a pressing challenge. Employing an in silico docking method, two coumaran (2,3-dihydrobenzofuran) derivatives-TB501 and TB515-were determined, with promising in vitro antimycobacterial activity. To enhance their effectiveness and reduce their cytotoxicity, we used liposomal drug carrier systems. Two types of small unilamellar vesicles (SUV) were prepared: multicomponent pH-sensitive stealth liposome (SUVmixed ) and monocomponent conventional liposome...
February 28, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/33659038/kr%C3%A3-ppel-like-factor-4-promotes-survival-and-expansion-in-acute-myeloid-leukemia-cells
#23
JOURNAL ARTICLE
Andrew Henry Lewis, Cory Seth Bridges, Viraaj Singh Punia, Abraham Fausto Jornada Cooper, Monica Puppi, H Daniel Lacorazza
Acute myeloid leukemia (AML) is an aggressive hematological malignancy of the bone marrow that affects mostly elderly adults. Alternative therapies are needed for AML patients because the overall prognosis with current standard of care, high dose chemotherapy and allogeneic transplantation, remains poor due to the emergence of refractory and relapsed disease. Here, we found expression of the transcription factor KLF4 in AML cell lines is not silenced through KLF4 gene methylation nor via proteasomal degradation...
February 16, 2021: Oncotarget
https://read.qxmd.com/read/33257389/secondary-pulmonary-alveolar-proteinosis-in-gata-2-deficiency-monomac-syndrome
#24
JOURNAL ARTICLE
Fazal I Raziq, Ahmed Abubaker, Eric Smith, Mohammed Uddin
We present here a case of a 29-year-old woman with a medical history of GATA-2 deficiency, who was under treatment for Mycobacterium avium intracellulare pneumonia. She presented with worsening dyspnoea with cough and fever. It was initially thought she had pneumonia but she was later diagnosed with Pulmonary Alveolar Proteinosis (PAP).
November 30, 2020: BMJ Case Reports
https://read.qxmd.com/read/33080470/the-anti-cancer-effect-of-flaxseed-lignan-derivatives-on-different-acute-myeloid-leukemia-cancer-cells
#25
JOURNAL ARTICLE
Stephanie Tannous, Tony Haykal, Jana Dhaini, Mohammad Hassan Hodroj, Sandra Rizk
Flaxseeds have been known for their anti-cancerous effects due to the high abundance of lignans released upon ingestion. The most abundant lignan, secoisolariciresinol diglucoside (SDG), is ingested during the dietary intake of flax, and is then metabolized in the gut into two mammalian lignan derivatives, Enterodiol (END) and Enterolactone (ENL). These lignans were previously reported to possess anti-tumor effects against breast, colon, and lung cancer. This study aims to investigate the potential anti-cancerous effect of the flaxseed lignans SDG, END and ENL on acute myeloid leukemia cells (AML) in vitro and to decipher the underlying molecular mechanism...
October 17, 2020: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/32372769/electrosprayed-poly-lactic-co-glycolic-acid-particles-as-a-promising-drug-delivery-system-for-the-novel-jnk-inhibitor-iq-1
#26
JOURNAL ARTICLE
Elina Kibler, Anastasia Lavrinenko, Ilya Kolesnik, Ksenia Stankevich, Evgeny Bolbasov, Valeriya Kudryavtseva, Andrey Leonov, Igor Schepetkin, Andrei Khlebnikov, Mark T Quinn, Sergei Tverdokhlebov
Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cytokine/JNK-driven diseases. Herein, we developed electrospray poly(lactic-co-glycolic acid) (PLGA) microparticles doped with novel JNK inhibitor 11 H -indeno[1,2- b ]quinoxalin-11-one oxime (IQ-1). Optimized electrospray parameters allowed us to produce IQ-1-doped microparticles with round shape, smooth and non-porous surface, and mean diameter of 0...
March 15, 2020: European Polymer Journal
https://read.qxmd.com/read/32120263/lps-induces-alox5-promoter-activation-and-5-lipoxygenase-expression-in-human-monocytic-cells
#27
JOURNAL ARTICLE
Samuel J Poirier, Luc H Boudreau, Nicolas Flamand, Marc E Surette
5-lipoxygenase (5-LO), coded by the ALOX5 gene, is expressed in leukocytes and catalyzes the formation of leukotrienes, pro-inflammatory lipid mediators. Leukotrienes are central to immune responses, but are also involved in inflammatory disorders and 5-LO expression is associated with leukemia stem cell survival. It is therefore important to understand mechanisms that control 5-LO expression. This study investigated the control of 5-LO expression and leukotriene biosynthesis following the maturation of human monocytic cells...
March 2020: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://read.qxmd.com/read/32052452/m2-differentiation-of-monomac-1-cell-line-induced-by-m-csf-and-glucocorticoid-pathways
#28
JOURNAL ARTICLE
Sarah Vakili, Tracy Fischer, Jay Rappaport
Models of macrophage subtypes require molecular characterization to reliably facilitate their differentiation. Although CD16+ (Fc-gamma III receptor) monocytes that express CD163 (a hemoglobin/haptoglobin receptor) have been implicated in a variety of disease states, the conditions necessary to establish lineages of these cell subtypes remains unknown. The current investigations utilize a cell line derived from acute myelogenous leukemia lineage, MonoMac-1, to interrogate the factors that promote the development of CD16+ macrophages that express CD163...
February 13, 2020: Journal of Cellular Physiology
https://read.qxmd.com/read/31830975/the-pro-apoptotic-effect-of-a-terpene-rich-annona-cherimola-leaf-extract-on-leukemic-cell-lines
#29
JOURNAL ARTICLE
Carl Ammoury, Maria Younes, Marianne El Khoury, Mohammad H Hodroj, Tony Haykal, Peter Nasr, Marilyne Sily, Robin I Taleb, Rita Sarkis, Rana Khalife, Sandra Rizk
BACKGROUND: The edible fruit Annona cherimola has previously shown many nutritional and medicinal properties. The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 and KG-1). METHODS: The anti-proliferative effect of A. cherimola ethanolic leaf extract was evaluated via cell viability assay. Its pro-apoptotic effect was assessed through Cell Death ELISA and dual Annexin V/PI staining...
December 12, 2019: BMC Complementary and Alternative Medicine
https://read.qxmd.com/read/31797748/evaluation-of-the-proinflammatory-effects-of-contaminated-bathing-water
#30
JOURNAL ARTICLE
Anas A Sattar, Wondwossen Abate, Gyorgy Fejer, Graham Bradley, Simon K Jackson
Contaminated marine bathing water has been reported to adversely affect human health. Our data demonstrated a correlation between total endotoxin (lipopolysaccharide; LPS) levels and degree of contamination of marine bathing waters. To assess the potential health implications of LPS present in marine bathing waters, the inflammation-inducing potency of water samples collected at different time points at multiple sampling sites were assessed using a cell culture-based assay. The numbers of fecal indicator bacteria (FIB) were also examined in the same samples...
December 4, 2019: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/31541142/the-bacterial-product-violacein-exerts-an-immunostimulatory-effect-via-tlr8
#31
JOURNAL ARTICLE
Francisco A Venegas, Gabriele Köllisch, Kerstin Mark, Wibke E Diederich, Andreas Kaufmann, Stefan Bauer, Max Chavarría, Juan J Araya, Alfonso J García-Piñeres
Violacein, an indole-derived, purple-colored natural pigment isolated from Chromobacterium violaceum has shown multiple biological activities. In this work, we studied the effect of violacein in different immune cell lines, namely THP-1, MonoMac 6, ANA-1, Raw 264.7 cells, as well as in human peripheral blood mononuclear cells (PBMCs). A stimulation of TNF-α production was observed in murine macrophages (ANA-1 and Raw 264.7), and in PBMCs, IL-6 and IL-1β secretion was detected. We obtained evidence of the molecular mechanism of activation by determining the mRNA expression pattern upon treatment with violacein in Raw 264...
September 20, 2019: Scientific Reports
https://read.qxmd.com/read/31493920/rage-and-ccr7-mediate-the-transmigration-of-zika-infected-monocytes-through-the-blood-brain-barrier
#32
JOURNAL ARTICLE
Gabriel Costa de Carvalho, Marie-Yolande Borget, Stéphane Bernier, Daniel Garneau, Alberto José da Silva Duarte, Nancy Dumais
Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of ZIKV-infected MonoMac-1 (MM-1) cells through the BBB is dependent on chemokine receptor 7 (CCR7) and receptor for advanced glycation end (RAGE); we also determined whether high mobility group box protein 1 (HMGB1) could facilitate the permeabilization of endothelial cells...
November 2019: Immunobiology
https://read.qxmd.com/read/31281163/-cancer-predisposition-in-inherited-bone-marrow-failure-syndromes-and-primary-immunodeficiency-diseases
#33
REVIEW
Masataka Ishimura, Shouichi Ohga
Inherited bone marrow failure syndromes (IBMFS) are caused by mutations in genes associated with DNA repair and telomere maintenance. In addition, mutations in ribosome-related genes cause defective hematopoiesis. Patients with IBMFS exhibit a predisposition to developing hematological malignancy or solid tumor because of the defect in cellular and molecular hemostasis. The SAMD9 mutation causes the multisystem disorder, MIRAGE syndrome, characterized by congenital adrenal hypoplasia and loss of chromosome 7, providing a novel insight into the correlation between the germline and somatic mutations of SAMD9/SAMD9L and myelodysplastic syndrome (MDS) with monosomy 7...
2019: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/31106410/impaired-immune-responses-to-herpesviruses-and-microbial-ligands-in-patients-with-monomac
#34
JOURNAL ARTICLE
Maibritt Mardahl, Sofie Eg Jørgensen, Alon Schneider, Klas Raaschou-Jensen, Mette Holm, Jens Veirum, Thomas K Kristensen, Isik S Johansen, Mette Christiansen, Kristian Assing, Trine H Mogensen
MonoMAC is a complex primary immunodeficiency caused by mutations in the myeloid transcription factor GATA2, characterized by multilineage cytopenia with malignant complications and severe infections, including mycobacteria and herpesviruses. We describe the clinical presentation, genetics and antiviral inflammatory responses in a small case series. Two patients presented in childhood with mycobacterial infection and were diagnosed with MonoMAC germline GATA2 variants; their healthy fathers with the same mutations were also studied...
August 2019: British Journal of Haematology
https://read.qxmd.com/read/30347329/synthesis-biological-evaluation-and-molecular-modeling-of-11h-indeno-1-2-b-quinoxalin-11-one-derivatives-and-tryptanthrin-6-oxime-as-c-jun-n-terminal-kinase-inhibitors
#35
JOURNAL ARTICLE
Igor A Schepetkin, Andrei I Khlebnikov, Andrei S Potapov, Anastasia R Kovrizhina, Vladislava V Matveevskaya, Maxim L Belyanin, Dmitriy N Atochin, Svitlana O Zanoza, Nadiya M Gaidarzhy, Sergiy A Lyakhov, Liliya N Kirpotina, Mark T Quinn
c-Jun N-terminal kinases (JNKs) play a central role in many physiologic and pathologic processes. We synthesized novel 11H-indeno[1,2-b]quinoxalin-11-one oxime analogs and tryptanthrin-6-oxime (indolo[2,1-b]quinazoline-6,12-dion-6-oxime) and evaluated their effects on JNK activity. Several compounds exhibited sub-micromolar JNK binding affinity and were selective for JNK1/JNK3 versus JNK2. The most potent compounds were 10c (11H-indeno[1,2-b]quinoxalin-11-one O-(O-ethylcarboxymethyl) oxime) and tryptanthrin-6-oxime, which had dissociation constants (Kd ) for JNK1 and JNK3 of 22 and 76 nM and 150 and 275 nM, respectively...
January 1, 2019: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/29929938/pge-2-enhanced-tnf%C3%AE-mediated-il-8-induction-in-monocytic-cell-lines-and-pbmc
#36
JOURNAL ARTICLE
F Neuschäfer-Rube, A Pathe-Neuschäfer-Rube, S Hippenstiel, G P Püschel
BACKGROUND & PURPOSE: Recent studies suggested a role of prostaglandin E2 (PGE2 ) in the expression of the chemokine IL-8 by monocytes. The function of EP4 receptor for TNFα-induced IL-8 expression was studied in monocytic cell lines. EXPERIMENTAL APPROACH: IL-8 mRNA and protein induction as well as IL-8 promoter activity and transcription factor activation were assessed in monocytic cell lines, primary blood mononuclear cells (PBMC) and transgenic HEK293 cells expressing the EP4 receptor...
January 2019: Cytokine
https://read.qxmd.com/read/29680795/monomac-syndrome-with-associated-neurological-deficits-and-longitudinally-extensive-cord-lesion
#37
JOURNAL ARTICLE
Mastura Monif, Aamira Huq, Lynette Chee, Trevor Kilpatrick
We present a case of monocytopaenia and mycobacteria-related infection (MonoMac) syndrome in a 30-year-old man of Indian origin. The clinical diagnosis of GATA2 haploinsufficiency was suspected after an unusual neurological presentation on a background of myelodysplastic syndrome and childhood pulmonary tuberculosis. The patient had a longitudinally extensive spinal cord lesion and a lesion in the medulla. No obvious infective cause for the spinal cord MRI abnormality was found, and the lesions were presumed to be inflammatory in nature...
April 21, 2018: BMJ Case Reports
https://read.qxmd.com/read/29618691/-monomac-syndrome-patient-developing-myelodysplastic-syndrome-following-persistent-ebv-infection
#38
JOURNAL ARTICLE
Hideyuki Yamamoto, Hikaru Hattori, Erina Takagi, Takanobu Morishita, Yuichi Ishikawa, Seitaro Terakura, Tetsuya Nishida, Yoshinori Ito, Makoto Murata, Hitoshi Kiyoi
An 18-year-old man was diagnosed with Epstein-Barr virus (EBV) -associated hemophagocytic syndrome (HPS) and treated with prednisolone (PSL) at a previous hospital. During PSL tapering, the HPS symptoms reappeared, and the patient was referred to our hospital. Increased PSL improved the symptoms, but the EBV infection remained unresolved. At age 20, he was admitted to our hospital for newly developed pneumonia and diagnosed with myelodysplastic syndrome (refractory cytopenia with multilineage dysplasia) (MDS-RCMD; normal karyotype, IPSS: Int-1) by bone marrow examination...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/28637621/gata2-deficiency-and-related-myeloid-neoplasms
#39
JOURNAL ARTICLE
Marcin W Wlodarski, Matthew Collin, Marshall S Horwitz
The GATA2 gene codes for a hematopoietic transcription factor that through its two zinc fingers (ZF) can occupy GATA-DNA motifs in a countless number of genes. It is crucial for the proliferation and maintenance of hematopoietic stem cells. During the past 5 years, germline heterozygous mutations in GATA2 were reported in several hundred patients with various phenotypes ranging from mild cytopenia to severe immunodeficiency involving B cells, natural killer cells, CD4+ cells, monocytes and dendritic cells (MonoMAC/DCML), and myeloid neoplasia...
April 2017: Seminars in Hematology
https://read.qxmd.com/read/28440875/skin-manifestations-among-gata2-deficient-patients
#40
JOURNAL ARTICLE
A Polat, M Dinulescu, S Fraitag, S Nimubona, F Toutain, S Jouneau, E Poullot, C Droitcourt, A Dupuy
GATA2 mutations have been identified in various diseases, such as MonoMAC syndrome, Emberger syndrome, familial myelodysplastic syndrome, acute myeloid leukaemia and dendritic cell, monocyte, B-cell and natural killer-cell deficiency. These syndromes present a wide range of clinical features, dominated by severe infections and haematological disorders such as myelodysplastic syndrome. Up to 70% of patients with GATA2 mutations have dermatological features, mainly genital or extragenital warts, panniculitis or erythema nodosum and lymphoedema...
March 2018: British Journal of Dermatology
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