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Prostate Cancer Focal Therapy

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https://www.readbyqxmd.com/read/29876151/re-salvage-mri-guided-focal-high-dose-rate-brachytherapy-for-locally-recurrent-prostate-cancer
#1
Marieke J Van Son, Max Peters, Marinus A Moerland, Juus L Noteboom, Wietse S Eppinga, Raquel Davila Fajardo, Jan Lagendijk, Jochem R Van der Voort van Zyp
Prostate cancer recurrences are common, even with twenty-first-century primary prostate cancer treatment modalities. The most common salvage treatment is (delayed) hormonal therapy, which is often associated with serious side-effects. Due to the risk of significant toxicity, whole-gland targeted salvage treatments remain unpopular. Consequently, developments in focal therapies have arisen. Magnetic resonance imaging (MRI)-guided focal salvage high-dose-rate brachytherapy (HDR-BT) is a novel treatment aiming for minimal toxicity in recurrent prostate cancer patients...
April 5, 2018: Curēus
https://www.readbyqxmd.com/read/29870466/mr-guided-prostate-interventions
#2
David A Woodrum, Krzysztof R Gorny, Lance A Mynderse
Prostate cancer is the most commonly diagnosed noncutaneous cancer and second leading cause of death in men. Many patients with clinically organ-confined prostate cancer undergo definitive treatment of the whole gland, including radical prostatectomy, radiation therapy, and cryosurgery. Active surveillance is a growing alternative option for patients with documented low-volume and low-grade prostate cancer. However, many patients are wanting a less morbid focal treatment alternative. With recent advances in software and hardware of magnetic resonance imaging (MRI), multiparametric MRI of the prostate has been shown to improve the accuracy in detecting and characterizing clinically significant prostate cancer...
June 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29858134/-prostate-brachytherapy-new-techniques-new-indications
#3
P Blanchard, P Graff-Cailleaud, A Bossi
Prostate brachytherapy has been for a long time one of the standard treatments for low risk prostate cancer, with high rates of biochemical control and low levels of urinary and sexual late toxicity compared to other available techniques, namely external beam radiotherapy and radical prostatectomy. The aim of this article is to review the recent innovations of prostate brachytherapy, which suggest a bright future for the technique. We will discuss the extension of indications of permanent implant brachytherapy to favorable intermediate-risk patients, the use of novel isotopes such as Palladium 103 and Cesium 131, and the benefit of brachytherapy as a boost following external beam radiotherapy for intermediate and high-risk patients...
May 29, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29845595/primary-cryotherapy-for-localised-or-locally-advanced-prostate-cancer
#4
REVIEW
Jae Hung Jung, Michael C Risk, Robert Goldfarb, Balaji Reddy, Bernadette Coles, Philipp Dahm
BACKGROUND: Traditionally, radical prostatectomy and radiotherapy with or without androgen deprivation therapy have been the main treatment options to attempt to cure men with localised or locally advanced prostate cancer. Cryotherapy is an alternative option for treatment of prostate cancer that involves freezing of the whole prostate (whole gland therapy) or only the cancer (focal therapy), but it is unclear how effective this is in comparison to other treatments. OBJECTIVES: To assess the effects of cryotherapy (whole gland or focal) compared with other interventions for primary treatment of clinically localised (cT1-T2) or locally-advanced (cT3) non-metastatic prostate cancer...
May 30, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29800634/robotic-management-of-recto-urethral-fistulas-after-focal-treatment-for-prostate-cancer
#5
Luis G Medina, Giovanni E Cacciamani, Angelica Hernandez, Hannah Landsberger, Leo Doumanian, Akbar N Ashrafi, Matthew Winter, Inderbir Gill, Rene Sotelo
OBJECTIVE: To describe our management strategy for RUF after focal treatment for prostate cancer (PCa) using two cases as an example. Almost 50% of recto-urethral fistulas (RUF) are associated with energy treatment modalities for PCa. The adjacent damage to healthy tissue along with limited pliability of it makes the success of the repair troublesome. There is no standardized approach for these scenarios. MATERIAL AND METHODS: Case 1: An 83 years old man underwent cryotherapy for PCa...
May 22, 2018: Urology
https://www.readbyqxmd.com/read/29790383/focal-treatment-for-unilateral-prostate-cancer-using-hifu-a-comprehensive-study-of-pooled-data
#6
Simone Albisinni, Christian Melot, Fouad Aoun, Ksenija Limani, Alexandre Peltier, Pascal Rischmann, Roland van Velthoven
BACKGROUND: Focal therapy for prostate cancer (PCa) remains experimental. Aim of the current study is to review available evidence and perform a pooled analysis exploring oncologic and functional results of High Intensity Focal Ultrasound (HIFU) focal therapy for the treatment of unilateral PCa. METHODS: The National Library of Medicine Database was searched for relevant articles. A wide search was performed including the combination of following words: "HIFU", "prostate", "cancer", "focal"...
May 23, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29784633/confocal-laser-endomicroscopy-and-optical-coherence-tomography-for-the-diagnosis-of-prostate-cancer-a-needle-based-in-vivo-feasibility-study-protocol-ideal-phase-2a
#7
Abel Swaan, Christophe K Mannaerts, Matthijs Jv Scheltema, Jakko A Nieuwenhuijzen, C Dilara Savci-Heijink, Jean Jmch de la Rosette, R Jeroen A van Moorselaar, Ton G van Leeuwen, Theo M de Reijke, Daniel Martijn de Bruin
BACKGROUND: Focal therapy for prostate cancer has been proposed as an alternative treatment to whole-gland therapies in selected men to diminish side effects in localized prostate cancer. As nowadays imaging cannot offer complete prostate cancer disease characterization, multicore systematic biopsies are recommended (transrectal or transperineal). Optical imaging techniques such as confocal laser endomicroscopy and optical coherence tomography allow in vivo, high-resolution imaging. Moreover, they can provide real-time visualization and analysis of tissue and have the potential to offer additive diagnostic information...
May 21, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29770311/-super-active-surveillance-mri-ultrasound-fusion-biopsy-and-ablation-for-less-invasive-management-of-prostate-cancer
#8
REVIEW
Jonathan B Bloom, Samuel A Gold, Graham R Hale, Kareem N Rayn, Vikram K Sabarwal, Ivane Bakhutashvili, Vladimir Valera, Baris Turkbey, Peter A Pinto, Bradford J Wood
Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29770305/the-prostate-cancer-focal-therapy
#9
REVIEW
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Edoardo Zanchetta, Chiara Floridi, Gianpaolo Carrafiello, Chloë Standaert
Despite prostate cancer (PCa) is the leading form of non-cutaneous cancer in men, most patients with PCa die with disease rather than of the disease. Therefore, the risk of overtreatment should be considered by clinicians who have to distinguish between patients with high risk PCa (who would benefit from radical treatment) and patients who may be managed more conservatively, such as through active surveillance or emerging focal therapy (FT). The aim of FT is to eradicate clinically significant disease while protecting key genito-urinary structures and function from injury...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29743538/which-technology-to-select-for-primary-focal-treatment-of-prostate-cancer-european-section-of-urotechnology-esut-position-statement
#10
REVIEW
Roman Ganzer, Vinodh Kumar Adithyaa Arthanareeswaran, Hashim U Ahmed, Andrea Cestari, Pascal Rischmann, Georg Salomon, Dogu Teber, Evangelos Liatsikos, Jens-Uwe Stolzenburg, Eric Barret
BACKGROUND: With growing interest in focal therapy (FT) of prostate cancer (PCa) there is an increasing armamentarium of treatment modalities including high-intensity focused ultrasound (HIFU), cryotherapy, focal laser ablation (FLA), irreversible electroporation (IRE), vascular targeted photodynamic therapy (VTP), focal brachytherapy (FBT) and stereotactic ablative radiotherapy (SABR). Currently there are no clear recommendations as to which of these technologies are appropriate for individual patient characteristics...
May 9, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29724502/focal-therapy-for-prostate-cancer-a-more-vehement-view-of-the-approach-could-translate-into-real-benefits-for-our-patients
#11
EDITORIAL
Rafael Sanchez-Salas, Jean de la Rosette, Thomas J Polascik, Arie Carneiro, Arjun Sivaraman, Xavier Cathelineau, Jochen Walz
The literature on focal therapy is currently insufficient to recommend it as first-line treatment. We need information from both randomised controlled trials and prospective registries for every available energy. That said, important research is under way in this field, and the door should be kept open to an approach that has the potential to offer adequate cancer control with lower morbidity and better post-treatment quality of life in properly selected patients.
April 30, 2018: European Urology
https://www.readbyqxmd.com/read/29716617/focal-dose-escalation-for-prostate-cancer-using-68-ga-hbed-cc-psma-pet-ct-and-mri-a-planning-study-based-on-histology-reference
#12
Constantinos Zamboglou, Benedikt Thomann, Khodor Koubar, Peter Bronsert, Tobias Krauss, Hans C Rischke, Ilias Sachpazidis, Vanessa Drendel, Nasr Salman, Kathrin Reichel, Cordula A Jilg, Martin Werner, Philipp T Meyer, Michael Bock, Dimos Baltas, Anca L Grosu
BACKGROUND: Focal radiation therapy has gained of interest in treatment of patients with primary prostate cancer (PCa). The question of how to define the intraprostatic boost volume is still open. Previous studies showed that multiparametric MRI (mpMRI) or PSMA PET alone could be used for boost volume definition. However, other studies proposed that the combined usage of both has the highest sensitivity in detection of intraprostatic lesions. The aim of this study was to demonstrate the feasibility and to evaluate the tumour control probability (TCP) and normal tissue complication probability (NTCP) of radiation therapy dose painting using 68 Ga-HBED-CC PSMA PET/CT, mpMRI or the combination of both in primary PCa...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29704582/robotic-single-port-partial-prostatectomy-for-anterior-tumors-transvesical-approach
#13
Jihad Kaouk, Juan Garisto, Daniel Sagalovich, Julien Dagenais, Riccardo Bertolo, Eric Klein
OBJECTIVES: To evaluate the feasibility of a single port transvesical robotic approach for anterior partial prostatectomy (SP-TVPP) in a cadaver model. METHODS: The cadavers were placed in a lithothomy position and secured to the operating table. A 3-cm midline incision was made in the suprapubic skin fold. After opening the Retzius space, a single-port mini device (GelPOINT, Rancho Margarita, California, USA) was introduced percutaneously directly into the bladder...
April 25, 2018: Urology
https://www.readbyqxmd.com/read/29702017/is-prostate-imaging-reporting-and-data-system-version-2-sufficiently-discovering-clinically-significant-prostate-cancer-per-lesion-radiology-pathology-correlation-study
#14
Myoung Seok Lee, Min Hoan Moon, Young A Kim, Chang Kyu Sung, Hyunsik Woo, Hyeon Jeong, Hwancheol Son
OBJECTIVE: The objective of our study was to evaluate the performance of multiparametric MRI with Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) for detecting prostate cancer (PCA) and clinically significant PCA through this per-lesion one-toone correlation study between pathologically proven lesions and MRI-visible lesions. MATERIALS AND METHODS: A total of 93 PCA lesions from 44 patients who underwent radical prostatectomy were included in this retrospective study...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29699883/expanding-indication-of-padeliporfin-wst11-vascular-targeted-photodynamic-therapy-results-of-prostate-cancer-latin-american-multicenter-study
#15
J A Rodriguez-Rivera, R Rodriguez-Lay, L Zegarra-Montes, F Benzaghou, B Gaillac, A R Azzouzi, L O Reis, P Palma
OBJECTIVES: To explore the proportion of patients with higher risk localized prostate cancer (PCa) that would become safely biopsy negative 12 months after non-thermal focal therapy with padeliporfin vascular-targeted photodynamic therapy (VTP). METHODS: Multicenter study in a scenario of prostate-specific antigen (PSA) ≤20ng/ml and variable PCa target volumes Gleason pattern 3 or low-volume secondary Gleason pattern 4, all patients received VTP, consisting of intravenous 4mg/kg padeliporfin activated by light-diffusing fibers in the prostate...
April 23, 2018: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29696431/magnetic-resonance-guided-focused-high-frequency-ultrasound-ablation-for-focal-therapy-in-prostate-cancer-phase-1-trial
#16
Sangeet Ghai, Nathan Perlis, Uri Lindner, Eugen Hlasny, Masoom A Haider, Antonio Finelli, Alexandre R Zlotta, Girish S Kulkarni, Theodorus H van der Kwast, Stuart A McCluskey, Walter Kucharczyk, John Trachtenberg
OBJECTIVES: To evaluate the feasibility and safety of focal therapy for low-intermediate risk prostate cancer (PCa) with magnetic resonance-guided high frequency focused ultrasound (MRgFUS) METHODS: This IRB-approved phase 1 prospective study enrolled eight patients with prostate specific antigen (PSA) ≤ 10 ng/ml, ≤ cT2a and Gleason score ≤ 7 (4 + 3) disease following informed consent. Under MRI guidance, focused high frequency ultrasound energy was delivered to ablate the target tissue...
April 25, 2018: European Radiology
https://www.readbyqxmd.com/read/29678358/impact-of-68-ga-psma-pet-on-the-management-of-patients-with-prostate-cancer-a-systematic-review-and-meta-analysis
#17
REVIEW
Sangwon Han, Sungmin Woo, Yeon Joo Kim, Chong Hyun Suh
CONTEXT: 68 Gallium prostate-specific membrane antigen positron emission tomography (68 Ga-PSMA PET) is an emerging imaging modality for assessment of prostate cancer. Recent studies show promising results regarding its ability to detect recurrent or metastatic prostate cancer superior to that of conventional imaging modalities. However, the impact of 68 Ga-PSMA PET on management of patients with prostate cancer has not been well established. OBJECTIVE: To perform a systematic review and meta-analysis to evaluate the impact of 68 Ga-PSMA PET on management of patients with prostate cancer...
April 18, 2018: European Urology
https://www.readbyqxmd.com/read/29664243/new-technologies-and-techniques-for-prostate-cancer-focal-therapy-a-review-of-the-current-literature
#18
Estefanía Linares-Espinós, Arie Carneiro, Juan I Martínez-Salamanca, Fernando Bianco, Adalberto Castro-Alfaro, Xavier Cathelineau, Massimo Valerio, Rafael Sanchez-Salas
BACKGROUND: The aim of this study was to review the oncological and functional outcomes of new and established primary focal treatments (FT) for localized prostate cancer (PCa). METHODS: We performed a systematic search of published studies on FT for localized PCa using electronic databases (Medline and Embase). These studies included reports on hemiablation, focal ablation and target-ablation. We excluded salvage focal therapy studies and limited the search to those with a minimum of 12 months of follow-up...
April 16, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29661587/medium-term-follow-up-of-vascular-targeted-photodynamic-therapy-of-localized-prostate-cancer-using-tookad-soluble-wst-11-phase-ii-trials
#19
A Noweski, A Roosen, S Lebdai, E Barret, M Emberton, F Benzaghou, M Apfelbeck, B Gaillac, C Gratzke, C Stief, A R Azzouzi
BACKGROUND AND OBJECTIVE: To assess the medium-term tumor control in patients with localized prostate cancer (PCa) treated with vascular-targeted photodynamic (VTP) therapy with TOOKAD Soluble WST11 (VTP) and to assess the medium-term tolerability of the treatment. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTION: During the clinical phase II studies, 68 patients were treated with VTP under optimal treatment conditions (WST11 at 4mg/kg, light energy at 200J/cm, and a light density index ≥1) and have been included in a 3...
April 13, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29660918/contrast-enhanced-ultrasound-ceus-with-mri-image-fusion-for-monitoring-focal-therapy-of-prostate-cancer-with-high-intensity-focused-ultrasound-hifu-1
#20
M Apfelbeck, D-A Clevert, J Ricke, C Stief, B Schlenker
INTRODUCTION: Reduced acceptance of radical prostatectomy in patients with low risk or intermediate risk prostate cancer has significantly changed treatment strategies in prostate cancer (PCa) during the last years. Focal therapy of the prostate with high intensity focused ultrasound (HIFU) is an organ-preserving treatment for prostate cancer with less impairment of health-related quality of life. Follow-up after HIFU therapy by imaging modalities remains a major problem as eg. MRI performs poorly...
2018: Clinical Hemorheology and Microcirculation
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