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Focal Ablation

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https://www.readbyqxmd.com/read/28541006/focal-atrial-tachycardia-arising-from-the-inferior-vena-cava
#1
Yeong Min Lim, Jae Sun Uhm, Hui Nam Pak
The inferior vena cava (IVC) is a rare site of focal atrial tachycardia (AT). Here, we report a 20-year-old woman who underwent catheter ablation for anti-arrhythmic drug-resistant AT originating from the IVC. She had undergone open-heart surgery for patch closure of an atrial septal defect 17 years previously and permanent pacemaker implantation for sinus node dysfunction 6 years previously. The AT focus was at the anterolateral aspect of the IVC-right atrial junction, and it was successfully ablated under three-dimensional electroanatomical-mapping guidance...
July 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28540816/numerical-evaluation-of-the-effect-of-electronically-steering-a-phased-array-transducer-axially-post-focal-shifting
#2
Mingjun Wang, Yufeng Zhou
PURPOSE: HIFU has been emerging as an effective and safe modality for the treatment of solid tumours and cancers. The focus shifting range of phased array HIFU transducer is an important safety concern because of the presence of grating lobe in the pre-focal region. However, previous studies were only based on linear acoustic wave model. MATERIALS AND METHODS: The nonlinear wave propagation from a 256-element phased array through multiple layered media was simulated using the angular spectrum approach (ASA) in marching fractional steps with the consideration of diffraction, attenuation and non-linearity effects by a second-order operator splitting scheme...
May 15, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28532939/guiding-flying-spot-laser-transepithelial-phototherapeutic-keratectomy-with-optical-coherence-tomography
#3
REVIEW
Yan Li, Hideaki Yokogawa, Maolong Tang, Winston Chamberlain, Xinbo Zhang, David Huang
PURPOSE: To analyze transepithelial phototherapeutic keratectomy (PTK) results using optical coherence tomography (OCT) and develop a model to guide the laser dioptric and depth settings. SETTING: Casey Eye Institute, Portland, Oregon, USA. DESIGN: Prospective nonrandomized case series. METHODS: Patients with superficial corneal opacities and irregularities had transepithelial PTK with a flying-spot excimer laser by combining wide-zone myopic and hyperopic astigmatic ablations...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28502693/prolonged-blood-brain-barrier-disruption-following-laser-interstitial-ablation-in-epilepsy-a-case-series-with-a-case-report-of-post-ablation-optic-neuritis
#4
Saint-Aaron Morris, Matthew Rollo, Patrick Rollo, Jessica Johnson, Gerald A Grant, Elliott Friedman, Giridhar Kalamangalam, Nitin Tandon
OBJECTIVE: Laser interstitial thermal therapy (LITT) has become increasingly popular for targeting epileptic foci in a minimally invasive fashion. Despite its use in more than a thousand patients, the chronic effects of photo-thermal injury on brain physiology remain poorly understood. METHODS: We prospectively followed the clinical and radiographic courses of a cohort undergoing laser ablation for focal epilepsy. Only patients with non-enhancing lesions and those who had a delayed post-operative MRI with gadolinium administration approximately 6 months after the ablation were considered...
May 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28485510/longstanding-persistent-accelerated-idioatrial-rhythm-benign-sinus-node-like-rhythm-or-insidious-rhythm
#5
Hailei Liu, Chao Zhu, Bing Yang, Weizhu Ju, Hongwu Chen, Fengxiang Zhang, Kai Gu, Mingfang Li, Pipin Kojodjojo, Minglong Chen
INTRODUCTION: Detailed description of longstanding persistent accelerated idioatrial rhythm (AIAR) is lacking. This observational study investigated the clinical manifestations, electrophysiological characteristics, diagnosis, treatment and prognosis of this unusual arrhythmia. METHODS AND RESULTS: Fifteen patients (11 males; average age 25.9±15.7 years) suspected with longstanding persistent AIAR were enrolled in our study. All patients had ECG, 24-hour Holter monitoring, isoproterenol provocation test, echocardiogram, and exercise treadmill test...
May 9, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28484842/conventional-mapping-and-ablation-of-focal-ventricular-tachycardias-in-the-healthy-heart
#6
REVIEW
Sonia Busch, Johannes Brachmann, Ahmed Saleh, Mathias Forkmann
Ventricular tachycardias (VT) in the healthy heart, also known as idiopathic VTs, often have a focal origin. Triggered activity due to delayed after-depolarization is the most likely mechanism of focal VTs. Localization of the site of origin of focal VTs is based on activation mapping with or without combination with pace mapping. The characteristic anatomic site of origin of idiopathic VTs is the right and left outflow tract. Other sites include the tricuspid and mitral annulus, the papillary muscles, and Purkinje fibers...
May 8, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28483841/trem2-deficiency-impairs-chemotaxis-and-microglial-responses-to-neuronal-injury
#7
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass
Sequence variations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to an increased risk for neurodegenerative disorders such as Alzheimer's disease and frontotemporal lobar degeneration. In the brain, TREM2 is predominantly expressed in microglia. Several disease-associated TREM2 variants result in a loss of function by reducing microglial phagocytosis, impairing lipid sensing, preventing binding of lipoproteins and affecting shielding of amyloid plaques. We here investigate the consequences of TREM2 loss of function on the microglia transcriptome...
May 8, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28479513/epicardial-endocardial-breakthrough-during-stable-atrial-macro-reentry-evidence-from-ultra-high-resolution-three-dimensional-mapping-epicardial-endocardial-breakthrough-in-atrial-macro-reentry
#8
Bhupesh Pathik, Geoffrey Lee, Frédéric Sacher, Michel Haïssaguerre, Pierre Jaïs, Grégoire Massoullié, Nicolas Derval, Prashanthan Sanders, Peter Kistler, Jonathan M Kalman
BACKGROUND: Evidence for epicardial-endocardial breakthrough(EEB) is derived from mapping inferences in patients with AF who may also have focal activations. OBJECTIVES: We investigated whether EEB could be discerned during stable right atrial macro-reentry using high-density high-spatial resolution 3D mapping. METHODS: Macro-reentry was diagnosed using 3D mapping and entrainment. Bipolar maps were reviewed for EEB defined as (i)focal endocardial activation with radial spread unaccounted for by an endocardial wavefront and (ii)present with the same timing on every tachycardia cycle...
May 4, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28477079/-irreversible-electroporation-ire-a%C3%A2-minimally-invasive-therapeutic-option-in-prostate-cancer
#9
REVIEW
P Wiggermann, K Brünn, W Bäumler
CLINICAL PROBLEM: Prostate cancer is one of the most common malignant diseases in older men. As such, screening and early detection are of crucial importance. STANDARD TREATMENT: The standard management of prostate cancer includes radical prostatectomy, radiation therapy, or hormonal therapy. These standard therapies yield excellent oncologic results, but also produce significant side effects. In cases of low-risk prostate cancer, these therapies might result in over-treatment; for this reason, active surveillance has been introduced...
May 5, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28476679/focal-atrial-tachycardias-from-the-para-hisian-region-strategies-for-mapping-and-catheter-ablation
#10
Jian-du Yang, Qi Sun, Xiao-Gang Guo, Gong-Bu Zhou, Xu Liu, Bin Luo, Hui-Qiang Wei, Jackson J Liang, Shu Zhang, Jian Ma
BACKGROUND: Focal atrial tachycardias (ATs) from the para-Hisian region can be successfully ablated from the right atrial septum (RAS), non-coronary cusp (NCC), and right middle septum (RMS). The optimal mapping and ablation strategy for ATs from these sites remains unclear. OBJECTIVE: We aimed to investigate the electrophysiologic characteristics and optimal ablation sites of para-Hisian ATs from the RAS, RMS, and NCC. METHODS: A total of 362 patients with ATs undergoing radiofrequency catheter ablation of ATs were included...
May 2, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28475107/evaluation-of-a-novel-therapeutic-focused-ultrasound-transducer-based-on-fermat-s-spiral
#11
P Ramaekers, M de Greef, R Berriet, C T W Moonen, M Ries
The purpose of this study was to evaluate a novel phased array transducer design rule for therapeutic focused ultrasound applications. This design rule uses the discretized Fermat's spiral to determine the positioning of the transducer elements for a given number of elements and f-number. Using this principle, three variations of Fermat's spiral were generated, aimed at (1) grating lobe minimization, (2) side lobe minimization, and (3) an optimized element packing efficiency. For each spiral, sparse layouts using identical circular elements and fully populated layouts based on additional Voronoi tessellation were evaluated numerically...
May 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28471019/type-and-rate-of-atrial-fibrillation-termination-due-to-rotational-activity-ablation-combined-with-pulmonary-vein-isolation
#12
Zsuzsanna Kis, Dominic A Theuns, Rohit Bhagwandien, Sip Wijchers, Sing-Chien Yap, Tamas Szili-Torok
BACKGROUND: There remains controversy about the optimal ablation technique and termination rate of atrial fibrillation (AF) during catheter ablation in patients with persistent AF. The aim of this study was to determine the rate and timing of AF termination during combined pulmonary vein isolation (PVI) and focal impulse and rotor modulation (FIRM)-guided ablation of rotational activity (RoAc). METHODS: This single-center, prospective cohort study enrolled 38 consecutive patients (63% male, mean age 63 ± 11 years) with persistent AF (mean left atrial size: 46 ± 7 mm), who underwent FIRM mapping and ablation of the identified RoAcs followed by PVI...
May 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28462605/editorial-comment-on-end-2016-0830-or-r1
#13
Joseph L Chin
"Focal therapy/Partial Ablation" for prostate cancer now garners significant attention and controversy. Critics and skeptics point to the known multifocality nature of prostate cancer, countered by proponents of focal therapy with the "dominant index lesion versus secondary lesions" theory. Tay et al. used the C.O.L.D. Registry to retrospectively assess oncologic and functional outcomes of partial cryoablation, comparing with a propensity score-matched group who had whole gland ablation. It should be emphasized that the authors selected for partial ablation only patients with low volume, intermediate risk disease...
May 2, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28462444/comparison-between-ct-and-mr-images-as-more-favorable-reference-data-sets-for-fusion-imaging-guided-radiofrequency-ablation-or-biopsy-of-hepatic-lesions-a-prospective-study-with-focus-on-patient-s-respiration
#14
Dong Ik Cha, Min Woo Lee, Tae Wook Kang, Young-Taek Oh, Ja-Yeon Jeong, Jung-Woo Chang, Jiwon Ryu, Kyong Joon Lee, Jaeil Kim, Won-Chul Bang, Dong Kuk Shin, Sung Jin Choi, Dalkwon Koh, Kyunga Kim
PURPOSE: To identify the more accurate reference data sets for fusion imaging-guided radiofrequency ablation or biopsy of hepatic lesions between computed tomography (CT) and magnetic resonance (MR) images. MATERIALS AND METHODS: This study was approved by the institutional review board, and written informed consent was received from all patients. Twelve consecutive patients who were referred to assess the feasibility of radiofrequency ablation or biopsy were enrolled...
May 1, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28462442/microwave-ablation-of-lung-tumors-near-the-heart-a-retrospective-review-of-short-term-procedural-safety-in-ten-patients
#15
Aaron W P Maxwell, Terrance T Healey, Damian E Dupuy
OBJECTIVES: To evaluate the rate of short-term complications associated with microwave ablation of lung tumors located near the heart. METHODS: This HIPAA-compliant study was performed with a waiver for informed consent. Patients who underwent microwave ablation of lung tumors located 10 mm or less from the heart were identified by retrospective chart review. Both primary and metastatic tumors were included. Only tumors directly adjacent to one of the four cardiac chambers were included...
May 1, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28451817/morphometric-analysis-of-high-intensity-focused-ultrasound-induced-lipolysis-on-cadaveric-abdominal-and-thigh-skin
#16
Sugun Lee, Hee-Jin Kim, Hyun Jun Park, Hyoung Moon Kim, So Hyun Lee, Sung Bin Cho
Non-focused ultrasound and high-intensity focused ultrasound (HIFU) devices induce lipolysis by generating acoustic cavitation and coagulation necrosis in targeted tissues. We aimed to investigate the morphometric characteristics of immediate tissue reactions induced by 2 MHz, 13-mm focused HIFU via two-dimensional ultrasound images and histologic evaluation of cadaveric skin from the abdomen and thigh. Acoustic fields of a 2 MHz, 38-mm HIFU transducer were characterized by reconstruction of the fields using acoustic intensity measurement...
April 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28441637/subtle-pathological-changes-in-neocortical-temporal-lobe-epilepsy
#17
Juan G Ochoa, Diana Hentgarden, Audrey Paulzak, Melissa Ogden, Richard Pryson, Markus Lamle, Walter G Rusyniak
This was a prospective observational study to correlate the clinical symptoms, electrophysiology, imaging, and surgical pathology of patients with temporal lobe epilepsy (TLE) without hippocampal sclerosis. We selected consecutive patients with TLE and normal MRI undergoing temporal lobe resection between April and September 2015. Clinical features, imaging, and functional data were reviewed. Intracranial monitoring and language mapping were performed when it was required according to our team recommendation...
April 22, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28441152/cryoablation-in-the-management-of-barrett-s-esophagus
#18
Anouk Overwater, Bas L A M Weusten
PURPOSE OF REVIEW: Providing an overview on types of cryotherapy for esophageal application and their role in the management of Barrett's esophagus. RECENT FINDINGS: Recent studies have involved multiple types of cryotherapy including cryospray techniques that use either liquid nitrogen or carbon dioxide as the cryogenic fluid, and the CryoBalloon focal ablation device that uses nitrous oxide. Overall, studies report cryotherapy to be safe and effective in eradicating Barrett's epithelium...
April 24, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28439616/-high-intensity-focused-ultrasound-hifu-importance-in-the-treatment-of-prostate-cancer
#19
R Ganzer
BACKGROUND: High intensity focused ultrasound (HIFU) has been used since the beginning of the 1990s as an alternative treatment for prostate cancer. OBJECTIVE: Overview of the current status and critical review of the different indications for HIFU in the treatment of prostate cancer. MATERIAL AND METHODS: Review of the current literature on the indications, side effects, oncologic results and current guideline recommendations. RESULTS: The principle of HIFU is based on high energy sound waves, which lead to coagulation necrosis at the focal point...
April 24, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28437003/high-intensity-focused-ultrasound-for-the-treatment-of-adenomyosis-selection-criteria-efficacy-safety-and-fertility
#20
Lian Zhang, Fangwen Rao, Raymond Setzen
Adenomyosis is a disorder of uterus in which endometrial glands and stroma are present within the uterine musculature. The main clinical manifestations are dysmenorrhea and menorrhagia. Adenomyosis has a great impact on both the quality of life and fertility of women. The treatment of adenomyosis remains an immense challenge MATERIAL AND METHODS: Relevant articles were searched through MEDLINE, Pubmed between 2000 and March 2017. The search terms of adenomyosis, magnetic resonance imaging (MRI) features of adenomyosis, high intensity focused ultrasound (HIFU), Ultrasound-guided HIFU and MRgFUS were used...
April 24, 2017: Acta Obstetricia et Gynecologica Scandinavica
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