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https://www.readbyqxmd.com/read/28528758/comparison-of-arterial-blood-pressure-measurements-obtained-invasively-or-oscillometrically-using-a-datex-s-5-compact-monitor-in-anaesthetised-adult-horses
#1
Tyfane T Yamaoka, Derek Flaherty, Patricia Pawson, Marian Scott, Adam Auckburally
OBJECTIVE: To assess agreement between noninvasive blood pressure (NIBP) oscillometrically-derived values from a multiparameter monitor (Datex Ohmeda S/5 Compact) with those obtained by invasive blood pressure (IBP) measurement in anaesthetised horses undergoing elective surgery. STUDY DESIGN: Prospective clinical study. ANIMALS: A total of 40 healthy adult horses. METHODS: Horses were anaesthetised with various anaesthetic protocols (based on clinical requirements)...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28512850/in-situ-handheld-3d-bioprinting-for-cartilage-regeneration
#2
Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Zhilian Yue, Fletcher Thompson, Christopher Richards, Stephen Beirne, Carmine Onofrillo, Sebastien H Bauquier, Stewart D Ryan, Peter Pivonka, Gordon G Wallace, Peter F Choong
Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ 3D printing is an exciting and innovative bio-fabrication technology that enables the surgeon to deliver tissue- engineering techniques at the time and location of need. We have created a hand- held 3D printing device (Biopen) that allows the simultaneous co-axial extrusion of bioscaffold and cultured cells directly into the cartilage defect in vivo in a single session surgery. This pilot study assesses the ability of the Biopen to repair a full thickness chondral defect and the early outcomes in cartilage regeneration, and compares these results to other treatments in a large animal model...
May 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28480761/topical-treatment-of-glaucoma-established-and-emerging-pharmacology
#3
Mark S Dikopf, Thasarat S Vajaranant, Deepak P Edward
Glaucoma is a collection of optic neuropathies consisting of retinal ganglion cell death and corresponding visual field loss. Glaucoma is the leading cause of irreversible vision loss worldwide and is forecasted to precipitously increase in prevalence in the coming decades. Current treatment options aim to lower intraocular pressure (IOP) via topical or oral therapy, laser treatment to the trabecular meshwork or ciliary body, and incisional surgery. Despite increasing use of trabecular laser therapy, topical therapy remains first-line in the treatment of most forms of glaucoma...
June 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28414674/a-clot-possibly-due-to-loss-of-tnf-%C3%AE-supression
#4
J Broussard, M Berlinger, D Lauret
INTRODUCTION: Inflammation and venous thrombosis enjoy a close Relationship. We present a patient who had multiple DVTs following the discontinuation of anti- TNF-α therapy. CASE: A 34 year old African American female with a history of multiple DVT's, miscarriages, and reported Crohn's disease presented with shortness of breath. In the Emergency Department, CTA showed bilateral pulmonary emboli. The patient had been off adalimumab for one year and reported abdominal pain with 6-7 non-bloody bowel movements daily...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28402559/occipital-nerve-stimulation-attenuates-neuronal-firing-response-to-mechanical-stimuli-in-the-ventral-posteromedial-thalamus-of-a-rodent-model-of-chronic-migraine
#5
Ian Walling, Heather Smith, Lucy E Gee, Brian Kaszuba, Arun Chockalingam, Andrei Barborica, Cristian Donos, Damian S Shin, Julie G Pilitsis
BACKGROUND: Chronic migraine (CM) is a highly debilitating disease, and many patients remain refractory to medicinal therapy. Given the convergent nature of neuronal networks in the ventral posteromedial nucleus (VPM) and the evidence of sensitization of pain circuitry in this disease, we hypothesize CM rats will have increased VPM neuronal firing, which can be attenuated using occipital nerve stimulation (ONS). OBJECTIVE: To determine whether VPM firing frequency differs between CM and sham rats, and whether ONS significantly alters firing rates during the application of mechanical stimuli...
April 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28355364/sheep-model-for-uterine-transplantation-the-best-option-before-starting-a-human-program
#6
Wellington Andraus, Dani Ejzenberg, Rafael Miyashiro Nunes Dos Santos, Luana Regina Baratelli Carelli Mendes, Rubens Macedo Arantes, Edmund Chada Baracat, Luiz Augusto Carneiro D'Albuquerque
OBJECTIVE: This study reports the first four cases of a uterine transplant procedure conducted in sheep in Latin America. The aim of this study was to evaluate the success of uterine transplantation in sheep. METHOD: The study was conducted at Laboratory of Medical Investigation 37 (LIM 37) at the University of São Paulo School of Medicine. Four healthy mature ewes weighing 40-60 kg were used as both the donor and recipient for a transplant within the same animal (auto-transplant)...
March 2017: Clinics
https://www.readbyqxmd.com/read/28337874/the-biomedical-aspects-of-oral-mucosal-epithelial-cell-culture-in-mammals
#7
A Bryja, M Dyszkiewicz-Konwińska, J Budna, W Kranc, A Chachuła, S Borys, S Ciesiółka, J Sokalski, M Prylinski, D Bukowska, P Antosik, M Bruska, M Nowicki, M Zabel, B Kempisty
In recent years, there has been a growing interest in epithelial cell tissue culture, particularly oral mucosa and its application utilizing in vitro cell culture in medicine. This involves tests using animal models to better understand oral mucosa function, and the differences in its construction in various animal models. The use of buccal pouch mucosal cell culture provides insight into the processes of trans mucosal transport and regeneration of the oral epithelium. The processes associated with epithelium regeneration is the base for stem cell research and/or oral cancer investigation...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28323640/a-micro-scale-printable-nanoclip-for-electrical-stimulation-and-recording-in-small-nerves
#8
Charles A Lissandrello, Winthrop F Gillis, Jun Shen, Ben W Pearre, Flavia Vitale, Matteo Pasquali, Bradley J Holinski, Daniel J Chew, Alice E White, Timothy J Gardner
OBJECTIVE: The vision of bioelectronic medicine is to treat disease by modulating the signaling of visceral nerves near various end organs. In small animal models, the nerves of interest can have small diameters and limited surgical access. New high-resolution methods for building nerve interfaces are desirable. In this study, we present a novel nerve interface and demonstrate its use for stimulation and recording in small nerves. APPROACH: We design and fabricate micro-scale electrode-laden nanoclips capable of interfacing with nerves as small as 50 µm in diameter...
June 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28292311/sonography-of-the-distal-urethra-in-lambs
#9
Ammar AlLugami, Kerstin von Pückler, Axel Wehrend, Marlene Sickinger
Sonography is a convenient, non-invasive diagnostic modality in small ruminants, often used in reproductive management, internal medicine, and surgery. Pregnancy diagnostics and imaging anatomy and pathology of organs, such as neoplasia, are major applications. Urolithiasis is one of the most common causes of death in male sheep and goats, for which sonography is the diagnostic modality of choice. Although ultrasound-imaging techniques for kidneys, ureters, and urinary bladder in small ruminants have been described previously, this study focuses on reporting the imaging technique of the extra-pelvic portion of the urethra, as nearly all the cases of obstructive urolithiasis result from urinary stones in this part...
March 14, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28287510/adsc-sheet-transplantation-to-prevent-stricture-after-extended-esophageal-endoscopic-submucosal-dissection
#10
Guillaume Perrod, Laetitia Pidial, Sophie Camilleri, Alexandre Bellucci, Amaury Casanova, Thomas Viel, Bertrand Tavitian, Chirstophe Cellier, Olivier Clément, Gabriel Rahmi
In past years, the cell-sheet construct has spurred wide interest in regenerative medicine, especially for reconstructive surgery procedures. The development of diversified technologies combining adipose tissue-derived stromal cells (ADSCs) with various biomaterials has led to the construction of numerous types of tissue-engineered substitutes, such as bone, cartilage, and adipose tissues from rodent, porcine, or human ADSCs. Extended esophageal endoscopic submucosal dissection (ESD) is responsible for esophageal stricture formation...
February 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28250702/an-evaluation-of-selected-indications-and-appropriateness-of-ampicillin-sulbactam-an-unrestricted-antimicrobial-at-a-single-center
#11
Dorothy McCoy, Rani Sebti, Arpi G Kuyumjian
BACKGROUND: With antimicrobial resistance on the rise and few new agents in development, it is important to exercise prudent judgment when utilizing antimicrobials. The Antimicrobial Stewardship Program (ASP) is responsible for facilitating the appropriate use of antimicrobials at the institution. Restricted antimicrobials and select additional antimicrobials are monitored by the ASP team to determine if the indications chosen by the ordering prescribers correspond to and are appropriate for the patients' infections...
March 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28240954/effect-of-cold-storage-on-immediate-graft-function-in-an-experimental-model-of-renal-transplantation-in-cats
#12
Rebecca A Csomos, Robert J Hardie, Chad W Schmiedt, Fern A Delaney, Jonathan F McAnulty
OBJECTIVE To assess the effect of cold storage (CS) on immediate posttransplantation function of renal autografts in cats. ANIMALS 15 healthy 1-year-old cats. PROCEDURES Cats were assigned to 2 groups and underwent autotransplantation of the left kidney followed by nephrectomy of the right kidney. The left kidney was autotransplanted either immediately (IT group; n = 6) or after being flushed with a cold sucrose phosphate solution and stored on ice while the implant site was prepared (CS group; 9). Serum creatinine and BUN concentrations were monitored daily and autografts were ultrasonographically examined intermittently for 14 days after surgery...
March 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28204935/a-review-of-body-dysmorphic-disorder-in-aesthetic-surgery-patients-and-the-legal-implications
#13
Iliana E Sweis, Jamie Spitz, David R Barry, Mimis Cohen
BACKGROUND: Body dysmorphic disorder (BDD) is an often under-recognized yet severe psychiatric illness. There is limited guidance for plastic surgeons in the USA in how to recognize and manage patients with BDD and protect themselves from potential litigation and harm. Therefore, in collaboration with legal counsel, we remind our profession of the serious nature of patients with BDD, provide warning signs for recognizing BDD, and critically evaluate the validity of informed consent and the legal ramifications of operating on such patients in the USA...
February 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28191762/periodontal-tissue-regeneration-using-syngeneic-adipose-derived-stromal-cells-in-a-mouse-model
#14
Mathieu Lemaitre, Paul Monsarrat, Vincent Blasco-Baque, Pascale Loubières, Rémy Burcelin, Louis Casteilla, Valérie Planat-Bénard, Philippe Kémoun
Current treatment of periodontitis is still associated with a high degree of variability in clinical outcomes. Recent advances in regenerative medicine by mesenchymal cells, including adipose stromal cells (ASC) have paved the way to improved periodontal regeneration (PD) but little is known about the biological processes involved. Here, we aimed to use syngeneic ASCs for periodontal regeneration in a new, relevant, bacteria-induced periodontitis model in mice. Periodontal defects were induced in female C57BL6/J mice by oral gavage with periodontal pathogens...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28164361/in-vivo-quantification-of-aortic-stiffness-using-mr-elastography-in-hypertensive-porcine-model
#15
Huiming Dong, Ria Mazumder, Venkata Sita Priyanka Illapani, Xiaokui Mo, Richard D White, Arunark Kolipaka
PURPOSE: Aortic stiffness plays an important role in evaluating and predicting the progression of systemic arterial hypertension (SAH). The aim of this study is to determine the stiffness of aortic wall using MR elastography (MRE) in a hypertensive porcine model and compare it against invasive aortic pressure measurements. METHODS: Renal wrapping surgery was performed on eight pigs to induce SAH. Aortic MRE was performed at baseline and 2 months postsurgery using a retrospectively pulse-gated gradient-echo MRE sequence on a 1...
February 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28154775/three-dimensional-printing-review-of-application-in-medicine-and-hepatic-surgery
#16
Rui Yao, Gang Xu, Shuang-Shuang Mao, Hua-Yu Yang, Xin-Ting Sang, Wei Sun, Yi-Lei Mao
Three-dimensional (3D) printing (3DP) is a rapid prototyping technology that has gained increasing recognition in many different fields. Inherent accuracy and low-cost property enable applicability of 3DP in many areas, such as manufacturing, aerospace, medical, and industrial design. Recently, 3DP has gained considerable attention in the medical field. The image data can be quickly turned into physical objects by using 3DP technology. These objects are being used across a variety of surgical specialties. The shortage of cadaver specimens is a major problem in medical education...
December 2016: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28062965/patient-satisfaction-and-clinical-outcomes-following-414-breast-reductions-application-of-breast-q
#17
A Cogliandro, M Barone, G Cassotta, S Tenna, B Cagli, P Persichetti
BACKGROUND: The aim of this study was to measure breast satisfaction and quality of life using the BREAST-Q Reduction Module in a large sample of postoperative patients having breast reduction using the inverted T technique. METHODS: With due approval from the ethics committee of our university, 414 patients who were seen in consultation for breast reduction surgery between 2005 and 2015 performed by the same team were asked to fill out BREAST-Q surveys. The patient factors collected for all those undergoing breast reduction included age, body mass index, incision pattern, areola complex pedicle used, amount of tissue resected, concurrent procedures, and complications...
January 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28039500/objective-outcome-measurement-after-upper-blepharoplasty-an-analysis-of-different-operative-techniques
#18
Ki-Soo Park, David Dae-Hwan Park
BACKGROUND: Upper blepharoplasty is indicated in Asians for double-eyelid fold creation, periorbital rejuvenation, and functional visual field improvement. This article introduces a technical classification for blepharoplasty methods and investigates approaches to evaluate its outcomes. METHODS: Of 535 patients undergoing aesthetic upper blepharoplasty in our institution in 1998-2011, 136 patients who were well followed up were retrospectively reviewed and categorized into four groups according to the techniques employed...
February 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28032175/patient-versus-surgeon-preferences-between-traditional-and-neo-omphaloplasty-in-post-bariatric-abdominoplasty
#19
Maria Gabriela Bonilha Vallim, Davi Reis Calderoni, Marco Antonio Camargo Bueno, Marcos Matias Motta, Rafael de Campos Ferreira Basso, Paulo Kharmandayan
BACKGROUND: Abdominoplasty procedures have been proven highly valuable in promoting better quality of life for post-bariatric surgery patients. The literature reveals that the aspect of the navel is one of the most problematic issues regarding surgical results and many different surgical techniques have been proposed to obtain a satisfactory outcome. However, little is known about patients' preferences regarding these different techniques and their results. The aim of the present study was to compare evaluations made by plastic surgeons and patients of the results of two different techniques-traditional omphaloplasty and neo-omphaloplasty with lateral flaps...
February 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/27999623/personalized-approach-in-brain-protection-by-hypothermia-individual-changes-in-non-pathological-and-ischemia-related-glutamate-transport-in-brain-nerve-terminals
#20
Artem Pastukhov, Natalia Krisanova, Vitalii Maksymenko, Tatiana Borisova
BACKGROUND: Both deep and profound hypothermia are effectively applied in cardiac surgery of the aortic arch, when the reduction of cerebral circulation facilitates operations, and for the prevention of ischemic stroke consequences. Neurochemical discrimination of the effects of deep and profound hypothermia (27 and 17 °C, respectively) on non-pathological and pathological ischemia-related mechanisms of presynaptic glutamate transport with its potential contribution to predictive, preventive and personalized medicine (PPPM) was performed...
2016: EPMA Journal
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