keyword
https://read.qxmd.com/read/38535706/static-magnetic-field-enhances-the-bone-remodelling-capacity-of-human-demineralized-bone-matrix-in-a-rat-animal-model-of-cranial-bone-defects
#1
JOURNAL ARTICLE
SeyedJamal Hosseini, Houman Parsaei, MirJavad Moosavifar, Narjes Tavakoli, Reza Ahadi, Kaveh Roshanbinfar
The regeneration of bone defects that exceed 2 cm is a challenge for the human body, necessitating interventional therapies. Demineralized bone matrices (DBM) derived from biological tissues have been employed for bone regeneration and possess notable osteoinductive and osteoconductive characteristics. Nevertheless, their efficiency in regenerating critically sized injuries is limited, and therefore additional signaling cues are required. Thanks to the piezoelectric properties of the bone, external physical stimulation is shown to accelerate tissue healing...
March 27, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38532826/neuropathology-and-epilepsy-surgery-2024-update
#2
JOURNAL ARTICLE
Ingmar Blümcke
Neuropathology-based studies in neurosurgically resected brain tissue obtained from carefully examined patients with focal epilepsies remain a treasure box for excellent insights into human neuroscience, including avenues to better understand the neurobiology of human brain organization and neuronal hyperexcitability at the cellular level including glio-neuronal interaction. It also allows to translate results from animal models in order to develop personalized treatment strategies in the near future. A nice example of this is the discovery of a new disease entity in 2017, termed mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy or MOGHE, in the frontal lobe of young children with intractable seizures...
January 2024: Free neuropathology
https://read.qxmd.com/read/38532201/enhancing-fat-transplantation-efficiency-in-a-mouse-model-through-pretreatment-of-adipose-derived-stem-cells-with-rip3-inhibitors
#3
JOURNAL ARTICLE
Zhenyu Yang, Haibin Lu, Qiuni Gao, Xihang Yuan, Yuling Hu, Zuoliang Qi
BACKGROUND: Autologous fat transplantation, widely used in cosmetic and reparative surgery for volumetric enhancements, faces challenges with its inconsistent long-term survival rates. The technique's efficacy, crucial for its development, is hindered by unpredictable outcomes. Enriching fat grafts with adipose-derived stem cells (ADSCs) shows promise in improving survival efficiency. OBJECTIVES: This study aimed to explore the potential of receptor-interacting protein kinase 3 (RIP3) kinase inhibitors as a pretreatment for ADSCs in enhancing autologous fat graft retention over a long term...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38532200/investigation-of-two-new-grafting-techniques-for-dorsal-augmentation-rhinoplasty-an-experimental-study-with-new-zealand-white-rabbits
#4
JOURNAL ARTICLE
Mehmet Ozdemır, Mehmet Fatih Akkoç, Selcuk Tunık
INTRODUCTION: Cartilage is an important source in supporting the structure of the nose for dorsal augmentation rhinoplasty. However, it is known that its viability is not always on the ideal level. Various wrapping materials are used to increase the strength of cartilage. Donor site morbidity, which develops following the harvesting of both cartilage and fascia as one such cover material, has attracted interest in recent years. OBJECTIVE: In this study, we aimed to investigate the potential of dermis and tendon autografts as alternatives to fascia and cartilage...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38528127/3d-bioprinting-based-dopamine-coupled-flexible-material-for-nasal-cartilage-repair
#5
JOURNAL ARTICLE
Wendan Jia, Zixian Liu, Zhuwei Ma, Peiyi Hou, Yanyan Cao, Zhizhong Shen, Meng Li, Hulin Zhang, Xing Guo, Shengbo Sang
INTRODUCTION: Since 3D printing can be used to design implants according to the specific conditions of patients, it has become an emerging technology in tissue engineering and regenerative medicine. How to improve the mechanical, elastic and adhesion properties of 3D-printed photocrosslinked hydrogels is the focus of cartilage tissue repair and reconstruction research. MATERIALS AND METHODS: We established a strategy for toughening hydrogels by mixing GelMA-DOPA (GD), which is prepared by coupling dopamine (DA) with GelMA, with HAMA, bacterial cellulose (BC) to produce composite hydrogels (HB-GD)...
March 25, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38527023/retinoic-acid-attenuates-ischemic-injury-induced-activation-of-glial-cells-and-inflammatory-factors-in-a-rat-stroke-model
#6
JOURNAL ARTICLE
Ju-Bin Kang, Hyun-Kyoung Son, Murad-Ali Shah, Phil-Ok Koh
Stroke is a leading cause of death and long-term disability which can cause oxidative damage and inflammation of the neuronal cells. Retinoic acid is an active metabolite of vitamin A that has various beneficial effects including antioxidant and anti-inflammatory effects. In this study, we investigated whether retinoic acid modulates oxidative stress and inflammatory factors in a stroke animal model. A middle cerebral artery occlusion (MCAO) was performed on adult male rats to induce focal cerebral ischemia...
2024: PloS One
https://read.qxmd.com/read/38521695/development-of-an-mr-guided-focused-ultrasound-mrgfus-lesioning-approach-for-the-fornix-in-the-rat-brain
#7
JOURNAL ARTICLE
Carena Cornelssen, Allison Payne, Dennis L Parker, Matthew Alexander, Robb Merrill, Sharayu Senthilkumar, Jacob Christensen, Karen S Wilcox, Henrik Odéen, John D Rolston
OBJECTIVE: High-intensity magnetic resonance-guided focused ultrasound (MRgFUS) is a non-invasive therapy to lesion brain tissue, used clinically in patients and pre-clinically in several animal models. Challenges with focused ablation in rodent brains can include skull and near-field heating and accurately targeting small and deep brain structures. We overcame these challenges by creating a novel method consisting of a craniectomy skull preparation, a high-frequency transducer (3 MHz) with a small ultrasound focal spot, a transducer positioning system with an added manual adjustment of ∼0...
March 22, 2024: Ultrasound in Medicine & Biology
https://read.qxmd.com/read/38519573/evaluation-of-different-fixation-methods-combinations-after-l-shaped-osteotomy-reduction-malarplasty-an-in-vitro-biomechanical-study
#8
JOURNAL ARTICLE
Mohammed Qasem Al-Watary, Jiansuo Hao, Yingyou He, Libin Song, Heyou Gao, Khaled Alkebsi, Saddam Ahmed Elayah, Bin Ye, Jihua Li
BACKGROUND: This in vitro study compared the stability of different fixation method combinations for the zygomatic complex after simulated L-shaped osteotomy reduction malarplasty, a common facial contouring surgery in East Asia with high postoperative complications due to poor fixation methods. MATERIALS AND METHODS: The study used 108 zygoma replicas with various fixation methods combinations in the zygomatic body (L-shaped plate with short wing on zygoma and on the maxilla, two bicortical screws, one bicortical screw with L-shaped plate, square plate, and rectangular plate) and zygomatic arch (Mortise-Tenon structure, 3-hole plate, and Mortise-Tenon structure plus short screw)...
March 22, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38519389/antenatal-administration-of-extracellular-vesicles-derived-from-amniotic-fluid-stem-cells-improves-lung-function-in-neonatal-rats-with-congenital-diaphragmatic-hernia
#9
JOURNAL ARTICLE
Rebeca L Figueira, Naghmeh Khoshgoo, Fabian Doktor, Kasra Khalaj, Tasneem Islam, Nazgol Moheimani, Matisse Blundell, Lina Antounians, Martin Post, Augusto Zani
BACKGROUND: The severity of pulmonary hypoplasia is a main determinant of outcome for babies with congenital diaphragmatic hernia (CDH). Antenatal administration of extracellular vesicles derived from amniotic fluid stem cells (AFSC-EVs) has been shown to rescue morphological features of lung development in the rat nitrofen model of CDH. Herein, we evaluated whether AFSC-EV administration to fetal rats with CDH is associated with neonatal improvement in lung function. METHODS: AFSC-EVs were isolated by ultracentrifugation and characterized by size, morphology, and canonical marker expression...
February 28, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38519369/augmenting-veterinary-minimally-invasive-surgery-evidence-based-review-of-foundational-and-novel-devices-and-technology
#10
REVIEW
Erin A Gibson
Veterinary minimally invasive surgery continues to grow as a specialty. With increasing experience in this field, comes improved accessibility as well as progressive complexity of procedures performed. Advancement in technology has been both a response to the growth and a necessary driver of continued refinement of this field. Innovative research leading to advancements in surgical equipment has led to the development of novel image acquisition platforms, cannulas, smoke evacuation systems, antifog devices, instrumentation, and ligating/hemostatic devices...
March 21, 2024: Veterinary Clinics of North America. Small Animal Practice
https://read.qxmd.com/read/38512407/greater-risk-taking-in-cosmetic-surgery-acceptance-and-history-an-experimental-and-computational-study
#11
JOURNAL ARTICLE
Paul Mark Jenkinson, Elena Panagiotopoulou, Athanasios Koukoutsakis, Aikaterini Fotopoulou
Cosmetic surgery is ever more affordable and accessible, but carries physical and psychological risks. Yet, no study to date has directly examined risk-taking behaviour under controlled conditions, beyond self-report and in relation to cosmetic surgery attitudes. We used the Balloon Analogue Risk Task and advanced computational modelling to measure decision-making behaviour and identify the latent parameters driving behaviour associated with cosmetic surgery attitudes in women with no cosmetic surgery history (N = 265) and a subsample of women with a cosmetic surgery history (N = 24)...
March 21, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38509736/catalpol-promotes-articular-cartilage-repair-by-enhancing-the-recruitment-of-endogenous-mesenchymal-stem-cells
#12
JOURNAL ARTICLE
Congzi Wu, Zhenyu Shi, Qinwen Ge, HuiHui Xu, Zhen Wu, Peijian Tong, Hongting Jin
Articular cartilage defect is challenged by insufficient regenerative ability of cartilage. Catalpol (CA), the primary active component of Rehmanniae Radix, could exert protective effects against various diseases. However, the impact of CA on the treatment of articular cartilage injuries is still unclear. In this study, full-thickness articular cartilage defect was induced in a mouse model via surgery. The animals were intraperitoneally injected with CA for 4 or 8 weeks. According to the results of macroscopic observation, micro-computed tomography CT (μCT), histological and immunohistochemistry staining, CA treatment could promote mouse cartilage repair, resulting in cartilage regeneration, bone structure improvement and matrix anabolism...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38509683/herbal-treatments-for-obesity-a-review
#13
JOURNAL ARTICLE
Amin Gasmi, Sadaf Noor, Pavan Kumar Mujawdiya, Muhammad Akram, Aisha Manzoor, Geir Bjørklund
Obesity is the most pervasive metabolic disorder, further linked with many other diseases, including diabetes, hypertension, cardiovascular disorders, and sleep apnea. To control the increasing weight of obese individuals, experts usually recommend exercise and lifestyle alterations, but medication and surgeries are also advised in severe cases. FDA-approved obesity-controlling drugs are effective but possess certain adverse effects, including dry mouth, drug abuse, dysregulation in monoamine neurotransmitters, insomnia, and many more...
March 20, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38508967/augmenting-laparoscopic-surgery-with-fluorescence-imaging
#14
REVIEW
Chris Thomson
Minimally invasive endoscopic surgery is growing in veterinary medicine, in large part, due to the advantages associated with reduced pain, potential for decreased complications, and increased visualization of structures through magnification and illumination. With advancing technologies, we can now improve upon natural "white light" endoscopy with fluorescence-guided imaging. Near-infrared (NIR) cameras allow for real-time, high-definition visualization of vessels, anatomic structures, and perfusion. New uses of NIR technologies during laparoscopy are continuing to grow for vascular, lymphatic, and oncologic-related techniques...
March 19, 2024: Veterinary Clinics of North America. Small Animal Practice
https://read.qxmd.com/read/38508966/near-infrared-guided-thoracoscopic-surgery-and-future-near-infrared-targets
#15
REVIEW
Chris Thomson
Intraoperative near-infrared fluorescence imaging allows for real time, noninvasive visualization of anatomic structures (blood vessels, lymphatic vessels) or diseased states (cancer, inflammation). This technique is easily adapted to thoracoscopy and has allowed for improved detection of lung tumors and other various cancers, thoracic lymphatics, and cardiothoracic vasculature.
March 19, 2024: Veterinary Clinics of North America. Small Animal Practice
https://read.qxmd.com/read/38508687/perioperative-evaluation-of-arterial-and-venous-whole-blood-in-the-lamb-ovis-aries-fontan-model
#16
JOURNAL ARTICLE
William E Schwartzman, Jingru Che, Mark A Naguib, Jack Palillo, Michael Jimenez, Mackenzie E Turner, Andrew R Yates, Carmen Arsuaga-Zorrilla, Christopher Breuer, John Kelly
Whole blood analysis can evaluate numerous parameters, including pH, pCO₂, pO₂, HCO₃- , base excess, glucose, electrolytes, lactate, blood urea nitrogen, creatinine, bilirubin, and hemoglobin. This valuable tool enables clinicians to make more informed decisions about patient care. However, the current body of literature describing perioperative whole blood analysis in Dorset sheep ( Ovis aries ) is small, so clinicians lack adequate information to guide their decision-making when evaluating test results...
March 20, 2024: Comparative Medicine
https://read.qxmd.com/read/38508490/evaluation-of-the-analgesic-effects-of-diclofenac-as-a-premedication-drug-in-dogs-undergoing-ovariohysterectomy
#17
JOURNAL ARTICLE
C Mansour, R Najjar, R Chaaya
Pre-emptive analgesia consists of administering drugs such as opioids and nonsteroid anti-inflammatory drugs. This study aims to evaluate the intraoperative antinociceptive effects of diclofenac administered alone in premedication or combined with morphine along with its potential influence on recovery of dogs undergoing ovariohysterectomy. A total of 34 dogs (ASA I or II) admitted for ovariohysterectomy were randomly allocated into three groups according to the drugs given in premedication: Diclofenac (D) (n=11), Morphine (M) (n=13) and Diclofenac-Morphine (DM) (n=10) groups...
March 18, 2024: Topics in Companion Animal Medicine
https://read.qxmd.com/read/38503655/target-trial-emulation-does-surgical-versus-non-surgical-management-of-cranial-cruciate-ligament-rupture-in-dogs-cause-different-outcomes
#18
JOURNAL ARTICLE
Camilla Pegram, Karla Diaz-Ordaz, Dave C Brodbelt, Yu-Mei Chang, Anna Frykfors von Hekkel, Chieh-Hsi Wu, David B Church, Dan G O'Neill
Target trial emulation applies design principles from randomised controlled trials to the analysis of observational data for causal inference and is increasingly used within human epidemiology. Using anonymised veterinary clinical data from the VetCompass Programme, this study applied the target trial emulation framework to determine whether surgical (compared to non-surgical) management for cranial cruciate ligament (CCL) rupture in dogs causes improved short- and long-term lameness and analgesia outcomes...
March 4, 2024: Preventive Veterinary Medicine
https://read.qxmd.com/read/38503597/laparoscopic-treatment-of-sliding-hiatal-hernia
#19
REVIEW
Sarah Marvel, Eric Monnet
Hiatal hernias result from a widening of the esophageal hiatus that leads to the displacement of the lower esophageal sphincter and stomach into the thoracic cavity. Clinical signs of regurgitation, gastroesophageal reflux, and esophagitis are managed medically, but surgery is considered in those that fail to respond to medical management. Surgical treatment of hiatal hernia can be performed laparoscopically. Treatment involves plication of the esophageal hiatus, as well as a pexy of the esophagus to the diaphragm and a left sided gastropexy...
March 18, 2024: Veterinary Clinics of North America. Small Animal Practice
https://read.qxmd.com/read/38499876/effect-of-injectable-acellular-adipose-matrix-on-soft-tissue-reconstruction-in-a-murine-model
#20
JOURNAL ARTICLE
Jaewoo Kim, Vinh Vuong The Tran, Ki Yong Hong, Hak Chang
BACKGROUND: The extracellular matrix isolated from adipose tissue, known as acellular adipose matrix (AAM), represents a novel biomaterial. AAM functions as a scaffold that not only supports stem cell proliferation and differentiation but also induces adipogenesis and angiogenesis. This study aims to investigate the volumetric effects and microenvironmental changes associated with injectable AAM in comparison to conventional fat grafting. METHODS: AAM was manufactured from fresh human abdominoplasty fat using a mechanically modified method and then transformed into an injectable form...
March 18, 2024: Aesthetic Plastic Surgery
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