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https://www.readbyqxmd.com/read/29777577/autologous-bone-marrow-mesenchymal-stem-cells-improve-the-quality-and-stability-of-vascularized-flap-surgery-of-irradiated-skin-in-pigs
#1
Christine Linard, Michel Brachet, Carine Strup-Perrot, Bruno L'homme, Elodie Busson, Claire Squiban, Valerie Holler, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey, Marc Benderitter
Cutaneous radiation syndrome has severe long-term health consequences. Because it causes an unpredictable course of inflammatory waves, conventional surgical treatment is ineffective and often leads to a fibronecrotic process. Data about the long-term stability of healed wounds, with neither inflammation nor resumption of fibrosis, are lacking. In this study, we investigated the effect of injections of local autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs), combined with plastic surgery for skin necrosis, in a large-animal model...
May 18, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29770299/regenerative-medicine-therapy-for-single-ventricle-congenital-heart-disease
#2
REVIEW
Chetan Ambastha, Gregory J Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal
One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29755358/therapeutic-angiogenesis-of-chinese-herbal-medicines-in-ischemic-heart-disease-a-review
#3
REVIEW
Dongqing Guo, Colin E Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29746994/shenfu-formula-reduces-cardiomyocyte-apoptosis-in-heart-failure-rats-by-regulating-micrornas
#4
Xu Yan, Hongjin Wu, Jianxun Ren, Yuna Liu, Shengqi Wang, Jiyuan Yang, Shuyan Qin, Delin Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Shenfu decoction consists of the water extract from the dried root or rootstalk of Panax ginseng C. A. Mey (Asian ginseng) and the lateral root of Aconitum carmichaeli Debx (Fuzi, Heishunpian in Chinese). Shenfu Formula has been used as a folk Chinese medicine for thousands of years. Recent studies have shown that Shenfu injection can enhance cardiac function and regulate arrhythmia. AIM OF THE STUDY: Shenfu Formula plays an important role in the treatment of heart failure...
May 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29732653/the-regenerative-journey-of-pericytes-towards-clinical-translation
#5
REVIEW
William Cathery, Ashton Faulkner, Davide Maselli, Paolo Madeddu
Coronary artery disease (CAD) is the single leading cause of death worldwide. Advances in treatment and management have significantly improved patient outcomes. On the other hand, although mortality rates have decreased, more people are left with sequelae that require additional treatment and hospitalization. Moreover, patients with severe nonrevascularizable CAD remain with the only option of heart transplantation, which is limited by the shortage of suitable hearts. In recent years, cell-based regenerative therapy has emerged as a possible alternative treatment, with several regenerative medicinal products already in the clinical phase of development and other emerging as competitive preclinical solutions...
May 7, 2018: Stem Cells
https://www.readbyqxmd.com/read/29727014/a-novel-rabbit-model-of-moderate-knee-contracture-induced-by-direct-capsular-damage
#6
David Hazlewood, Yi Feng, Qinghua Lu, Xinmai Yang, Jinxi Wang
The treatment of joint contracture continues to represent a challenging problem in orthopedic surgery and rehabilitation medicine. Existing animal models of knee contracture for evaluating new treatments are mostly created by extensive joint tissue damage with Kirschner-wire immobilization which requires a second surgery to remove Kirschner-wires. This study aimed to develop a less invasive rabbit model of moderate knee contracture through a single surgery. Skeletally mature New Zealand White rabbits had their right knee operated to create surgical damage to the posterior capsule under direct visualization...
May 4, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29685993/osteoblast-differentiation-of-equine-induced-pluripotent-stem-cells
#7
Arabella Baird, Timothy Lindsay, Alice Everett, Valentine Iyemere, Yasmin Z Paterson, Alyce McClellan, Frances M D Henson, Deborah J Guest
Bone fractures occur in horses following traumatic and non-traumatic (bone overloading) events. They can be difficult to treat due to the need for the horse to bear weight on all legs during the healing period. Regenerative medicine to improve fracture union and recovery could significantly improve horse welfare.Equine induced pluripotent stem cells (iPSCs) have previously been derived. Here we show that equine iPSCs cultured for 21 days in osteogenic induction media on an OsteoAssay surface upregulate the expression of osteoblast associated genes and proteins, including COL1A1 , SPARC , SPP1 , IBSP , RUNX2 and BGALP We also demonstrate that iPSC-osteoblasts are able to produce a mineralised matrix with both calcium and hydroxyapatite deposition...
April 23, 2018: Biology Open
https://www.readbyqxmd.com/read/29682573/antibody-mediated-osseous-regeneration-for-bone-tissue-engineering-in-canine-segmental-defects
#8
A Khojasteh, S Hosseinpour, M M Dehghan, F Mashhadiabbas, M Rezai Rad, S Ansari, S Farzad Mohajeri, H H Zadeh
Among many applications of therapeutic monoclonal antibodies (mAbs), a unique approach for regenerative medicine has entailed antibody-mediated osseous regeneration (AMOR). In an effort to identify a clinically relevant model of craniofacial defect, the present study investigated the efficacy of mAb specific for bone morphogenetic protein- (BMP-) 2 to repair canine segmental mandibular continuity defect model. Accordingly, a 15 mm unilateral segmental defect was created in mandible and fixated with a titanium plate...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29676227/chemically-modified-mrna-modified-rna-application-for-treatment-of-achilles-tendon-defects
#9
Elmar Herbst, Florian Imhoff, Peter Föhr, Stefan Milz, Christian Plank, Carsten Rudolph, Günther Hasenpusch, Johannes Geiger, Manish Aneja, Karoline Groth, Stephan Vogt, Andreas Imhoff, Andreas Schmitt
Different regenerative medicine approaches for tendon healing exist. Recently, especially gene therapy gained popularity. However, potential mutagenic and immunologic effects might prevent from translation to clinical research. Chemically modified mRNA (cmRNA) might bypass these limitations of gene therapy. Therefore, the purpose of this study was to evaluate the early healing properties of Achilles tendon defects in rats treated with basic fibroblast growth factor (bFGF) cmRNA. Forty male Lewis rats were used for the study and randomly assigned to the two study groups: 1) treatment with cmRNA coding for bFGF, 2) non-coding cmRNA control...
April 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29629881/propofol-a-safe-anaesthetic-drug-in-experimental-cardiac-surgery-in-rabbits
#10
Enrico Giuliani, Antonio Manenti, Alberto Barbieri, Alberto Farinetti, Anna Vittoria Mattioli
ACKGROUND: Experimental surgery needs a pharmacological approach that can interfere with cardiac function. CASE REPORT: In a animal model of regenerative medicine of myocardium we use an anaesthesiological protocol that included Propofol, a benzodiazepine (Midazolam) and an alpha-2 adrenergic agent. RESULTS: In a group of 15 rabbits undergoing cardiac surgery we reported 1 arrhythmic complication during stem cell injection. DISCUSSION: The functional cardio- respiratory depressor activity of Propofol was compensated by alpha-2 adrenergic drugs, avoiding serious complications...
2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29623690/observation-about-phosphorus-and-protein-supply-in-cats-and-dogs-prior-to-the-diagnosis-of-chronic-kidney-disease
#11
L F Böswald, E Kienzle, B Dobenecker
There is evidence that nutritional phosphorus (P) excess may be a risk factor for chronic kidney disease (CKD) in humans and pets (Advances in Nutrition: An International Review Journal (2014), 5, 104; The American Journal of Clinical Nutrition, (2013), 98, 6; Journal of Feline Medicine and Surgery, (2017); The source of phosphorus influences serum PTH, apparent digestibility and blood levels of calcium and phosphorus in dogs fed high phosphorus diets with balanced Ca/P ratio. Proc. Waltham International Nutritional Sciences Symposium, USA; Clinical aspects of natural and added phosphorus in foods, 2017, Springer Science+Business, Media)...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29576309/preventive-effect-of-oral-hangeshashinto-tj-14-on-the-development-of-reflux-induced-esophageal-cancer
#12
Tomoharu Miyashita, Toru Kono, Daisuke Matsui, Yuki Yamazaki, Daichi Sadatomi, Naoki Fujitsuka, Shinichi Nakanuma, Koichi Okamoto, Isamu Makino, Jun Kinoshita, Keishi Nakamura, Katsunobu Oyama, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Kenichi Mukaisho, John W Harmon, Tetsuo Ohta
BACKGROUND: Prostaglandin E2 is one of the potential products that promotes development of tumors and also is a strong inducer of M2 phenotype macrophages, which contribute to tumor development in the immunosuppressed microenvironment. Hangeshashinto (TJ-14), a Japanese traditional medicine (Kampo medicine), has been reported to be effective in preventing chemotherapy-induced oral mucositis through the reduction of prostaglandin E2. We previously developed a surgical rat reflux model of esophageal cancer and used this well-established animal model to investigate the action of TJ-14 in preventing esophageal cancer...
March 22, 2018: Surgery
https://www.readbyqxmd.com/read/29569338/gorilla-endoscopic-sinus-surgery-a-life-saving-collaboration-between-human-and-veterinary-medicine
#13
Greg E Davis, Fred M Baik, Robert M Liddell, Andrew G Ayars, Kelley R Branch, Paul S Pottinger, Allen D Hillel, Kelly Helmick, Darin Collins
BACKGROUND: Chronic rhinosinusitis is a common disease process in humans; however, in the primate population of gorillas, it has rarely been described. This case describes lifesaving sinus surgery on a critically ill gorilla performed by a human otolaryngology team in collaboration with the gorilla's veterinary medicine team. METHODS: The 35-year-old western silverback gorilla was treated for 3 months with aggressive medical therapy for a worsening sinus infection...
March 23, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29564486/evaluation-of-safe-systemic-immunosuppression-created-with-dexamethasone-in-prevention-of-capsular-contracture-a-glance-to-distinct-perspectives-with-toll-like-receptors
#14
Ozlem Colak, Kadri Ozer, Adile Dikmen, Hilal Ozakinci, Ozay Ozkaya
PURPOSE: The toll-like receptors (TLRs) stand at the interface of innate immune activation. We hypothesize to decrease the response of innate immunity activated by TLR4 by a safe, short-term, systemic immunosuppression. METHODS: Two silicone block implants were placed into two dorsal subcutaneous pockets in 32 rats that were subdivided into four groups: The two study groups were the IV DEX group (single intravenous injection of dexamethasone 1 h before surgery) and the IV DEX + IP DEX group (in addition to a single intravenous injection of dexamethasone 1 h before surgery, intraperitoneal dexamethasone was administered for 10 days after surgery), and the two control groups were the untreated control group and the saline-treated control group...
March 21, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29544019/utility-of-two-view-vs-three-view-abdominal-radiography-in-canines-presenting-with-acute-abdominal-signs
#15
Marina V Mavromatis, Mauricio Solano, Michael Y Thelen
There are clear differences in the normal radiographic appearance of the abdominal organs between a left lateral vs. a right lateral view. While a few veterinary academic institutions have transitioned to a three-view abdominal radiographic study protocol, obtaining only two views of the canine abdomen remains the current standard in veterinary medicine. In this combined retrospective and prospective, case-controlled study, 48 canine patients presenting with signs of acute abdomen were recruited. Four board-certified veterinary radiologists and four general practice veterinarians with greater than 3 years of experience in small animal practice were asked to determine if 10 predetermined findings were present within the set of images and if surgery was recommended based on those findings...
March 15, 2018: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29540169/skin-asepsis-protocols-as-a-preventive-measure-of-surgical-site-infections-in-dogs-chlorhexidine-alcohol-versus-povidone-iodine
#16
Luís Belo, Isa Serrano, Eva Cunha, Carla Carneiro, Luis Tavares, L Miguel Carreira, Manuela Oliveira
BACKGROUND: Most of surgical site infections (SSI) are caused by commensal and pathogenic agents from the patient's microbiota, which may include antibiotic resistant strains. Pre-surgical asepsis of the skin is one of the preventive measures performed to reduce SSI incidence and also antibiotic resistance dissemination. However, in veterinary medicine there is no agreement on which biocide is the most effective. The aim of this study was to evaluate the effectiveness of two pre-surgical skin asepsis protocols in dogs...
March 14, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29500540/evaluation-of-the-chemopreventive-effects-of-ankaferd-bloodstopper-in-7-12-dimethylbenz-a-anthracene-induced-oral-epithelial-dysplasia
#17
Murat Ozle, Dilek A Uğar Çankal, Mert Ilhan, Hikmet Keleş, Esra Küpeli Akkol
OBJECTIVES: Ankaferd BloodStopper® (ABS) is an herbal extract which has been used historically as a hemostatic agent in traditional Turkish medicine. ABS comprises of standardized mixture of herbs Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica dioica. In addition to its hemostatic effects, the herb ABS contains some other biological effects including antioxidant and antitumoral properties. The aim of this study is to investigate the chemopreventive effects of ABS in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral epithelial dysplasia...
March 2, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29496176/rosmarinic-acid-attenuates-development-and-existing-pain-in-a-rat-model-of-neuropathic-pain-an-evidence-of-anti-oxidative-and-anti-inflammatory-effects
#18
Mahboobeh Ghasemzadeh Rahbardar, Bahareh Amin, Soghra Mehri, Seyed Javad Mirnajafi-Zadeh, Hossein Hosseinzadeh
BACKGROUND: We aimed to investigate the potential prophylactic and curative effects of rosmarinic acid, one of the main constituents of rosemary, on the neuropathic pain induced by chronic constriction injury (CCI) in rats. MATERIALS AND METHODS: CCI was used to induce peripheral neuropathic pain. In prophylactic groups, rosmarinic acid (10, 20, and 40 mg/kg, i.p.) was administered from the day of surgery (day 0) for 14 days. In treatment group, rosmarinic acid (40 mg/kg) was given from day 5 (after the pain was established), for 7 days...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29496171/resveratrol-combined-with-total-flavones-of-hawthorn-alleviate-the-endothelial-cells-injury-after-coronary-bypass-graft-surgery
#19
Ying Zhu, Bing Feng, Songmin He, Zuqing Su, Guangjuan Zheng
OBJECTIVE: To explore the preventive and therapeutic effects of Resveratrol combined with total flavones of hawthorn, compatibility of traditional Chinese medicines, on the endothelial cells injury after artery bypass graft surgery. METHODS: The animal model of coronary artery bypass grafting (CABG) was prepared by transplanting a segment of autologous jugular vein onto the transected common carotid artery in rabbits. After CABG surgery, the rabbits were administrated with saline (model group), aspirin (Aspirin group), resveratrol (Res group), total flavones of hawthorn (Haw group) and resveratrol combined with total flavones of hawthorn (Res+Haw group) once a day for eight weeks, respectively...
February 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29489449/hepatoprotective-effect-of-essential-oils-from-hyptis-crenata-in-sepsis-induced-liver-dysfunction
#20
Glauber Cruz Lima, Yuri de Abreu Gomes Vasconcelos, Marilia Trindade de Santana Souza, Alan Santos Oliveira, Rangel Rodrigues Bomfim, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Enilton Aparecido Camargo, Viviane Gomes Portella, Andrelina Noronha Coelho-de-Souza, Lúcio Ricardo Leite Diniz
No specific therapeutics are available for the treatment of sepsis-induced liver dysfunction, a clinical complication strongly associated with the high mortality rate of septic patients. This study investigated the effect of the essential oil of Hyptis crenata (EOHc), a lamiaceae plant used to treat liver disturbances in Brazilian folk medicine, on liver function during early sepsis. Sepsis was induced by the cecal ligation and puncture (CLP) model. Rats were divided into four groups: Sham, Sham+EOHc, CLP, and CLP+EOHc...
February 28, 2018: Journal of Medicinal Food
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