Patrick M Pilz, Miriam Lang, Ouafa Hamza, Petra L Szabo, Milat Inci, Anne M Kramer, Michael Koch, Johann Huber, Bruno K Podesser, Attila Kiss
Myocardial infarction (MI) remains the main contributor to morbidity and mortality worldwide. Therefore, research on this topic is mandatory. An easily and highly reproducible MI induction procedure is required to obtain further insight and better understanding of the underlying pathological changes. This procedure can also be used to evaluate the effects or potency of new and promising treatments (as drugs or interventions) in acute MI, subsequent remodeling and heart failure (HF). After intubation and pre-operative preparation of the animal, an anesthetic protocol with isoflurane was performed, and the surgical procedure was conducted quickly...
June 11, 2020: Journal of Visualized Experiments: JoVE