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Regenerative endodontic

Shin Hye Chung, Young-Seok Park, Kwang-Shik Bae, Seung-Ho Baek, Kee-Yeon Kum, Woocheol Lee, Won-Jun Shon
Endodontic implant pathology (EIP) refers to cases in which endodontic infections cause infections in adjacent implants, and vice versa. This case report demonstrates the successful resolution of two types of EIPs, implant endodontitis and endodontic implantitis, by endodontic intervention with surgical treatment. In case 1, the patient complained of tooth discomfort after implant placement in the adjacent tooth. The tooth was sensitive to percussion and showed slight mobility with a negative reaction to an electric pulp test...
November 2016: International Journal of Periodontics & Restorative Dentistry
Priyanka D Rebentish, Girish Umashetty, Harpreet Kaur, Trupthi Doizode, Mithun Kaslekar, Shouvik Chowdhury
Research into regenerative dentistry has contributed momentum to the field of molecular biology. Periapical surgery aims at removing periapical pathology to achieve complete wound healing and regeneration of bone and periodontal tissue. Regenerative endodontic procedures are widely being added to the current armamentarium of pulp therapy procedures. The regenerative potential of platelets has been deliberated. Platelet-rich fibrin (PRF) is a wonderful tissue-engineering product and has recently gained much popularity due its promising results in wound healing bone induction...
December 2016: Minerva Stomatologica
P Verma, A Nosrat, J R Kim, J B Price, P Wang, E Bair, H H Xu, A F Fouad
It is not known to what extent residual infection may interfere with the success of pulp regeneration procedures. The aim of this study was to determine, radiographically and histologically, the effect of residual bacteria on the outcome of pulp regeneration mediated by a tissue-engineered construct as compared with traditional revascularization. Periapical lesions were induced in 24 canine teeth of 6 ferrets. After disinfection with 1.25% NaOCl and triple antibiotic paste, ferret dental pulp stem cells, encapsulated in a hydrogel scaffold, were injected into half the experimental teeth...
September 30, 2016: Journal of Dental Research
Divya Pankajakshan, Maria T P Albuquerque, Joshua D Evans, Malgorzata M Kamocka, Richard L Gregory, Marco C Bottino
INTRODUCTION: Root canal disinfection and the establishment of an intracanal microenvironment conducive to the proliferation/differentiation of stem cells play a significant role in regenerative endodontics. This study was designed to (1) investigate the antimicrobial efficacy of triple antibiotic-containing nanofibers against a dual-species biofilm and (2) evaluate the ability of dental pulp stem cells (DPSCs) to adhere to and proliferate on dentin upon nanofiber exposure. METHODS: Seven-day-old dual-species biofilm established on dentin specimens was exposed for 3 days to the following: saline (control), antibiotic-free nanofibers (control), and triple antibiotic-containing nanofibers or a saturated triple antibiotic paste (TAP) solution (50 mg/mL in phosphate buffer solution)...
October 2016: Journal of Endodontics
Yeon-Jee Yoo, Joung-Hwan Oh, WooCheol Lee, Kyung Mi Woo
INTRODUCTION: The purpose of this study was to ascertain the regenerative characteristics of apical papilla-derived cells (APDCs) from immature teeth with pulpal and periapical pathosis and thus to provide proof-of-principle evidence for further regenerative endodontic research. METHODS: Pulpal and periapical pathosis was induced in immature permanent double-rooted premolars of beagles, which were randomly assigned to experimental treatment groups: group AO (n = 14), pulp disruption and access left open; group PS (n = 14), supragingival plaque suspension-soaked cotton pellet was introduced, and access was sealed; and control (n = 7), untreated...
September 14, 2016: Journal of Endodontics
William N Ha, Peter Duckmanton, Bill Kahler, Laurence J Walsh
This study aims to assess education on the use of mineral trioxide aggregate (MTA) and Biodentine among members of the Australian Society of Endodontology (ASE), a society of specialist endodontists (ED) and general dentists with an interest in endodontics (GD). The study also aims to compare the procedural preferences relating to perforation repair, apical barrier, root-end filling and regenerative endodontics. A structured online questionnaire was used, which sought details of the education in the use of MTA and the procedural steps involved in perforation repair, apical barrier, root-end filling and regenerative endodontics...
September 15, 2016: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
Bishoy Safwat Estefan, Kariem Mostafa El Batouty, Mohamed Mokhtar Nagy, Anibal Diogenes
INTRODUCTION: Treatment of immature permanent teeth with necrotic pulp and apical pathosis constitutes a challenge for endodontists. The present study was done to evaluate the effect of age and apical diameter on the regenerative potential of young permanent immature teeth with necrotic pulps. METHODS: Immature necrotic permanent maxillary incisors (n = 40) of patients 9-18 years old were divided into 2 groups according to the treatment protocol: group Y (younger age group), 9-13 years and group O (older age group), 14-18 years...
September 9, 2016: Journal of Endodontics
Saeed Asgary, Mahta Fazlyab, Ali Nosrat
This report compares and evaluates the treatment outcomes of regenerative endodontic treatment and apical plug as two accepted treatment protocols in a pair of necrotic immature maxillary central incisors of a 12-year old female. The patient was referred complaining of a dull pain and swelling in her upper lip area. She had a history of trauma to the anterior maxilla two years earlier. Both teeth were clinically diagnosed with pulp necrosis and periapical radiographs revealed that separate periapical radiolucent lesions surrounded the immature apices of both teeth...
2016: Journal of Clinical Pediatric Dentistry
Ausra Ramanauskaite, Gintaras Juodzbalys, Tolga F Tözüm
OBJECTIVES: To review the literature on retrograde periimplantitis symptoms, risk factors, and treatment methods and to propose a decision-making tree of retrograde periimplantitis management. MATERIALS AND METHODS: An electronic literature search was conducted on the MEDLINE and EMBASE databases for articles published between 1990 and 2015. Clinical human studies in the English language were included. RESULTS: The search resulted in 44 case reports published by 27 authors...
October 2016: Implant Dentistry
Tarek Mohamed A Saoud, Sonali Mistry, Bill Kahler, Asgeir Sigurdsson, Louis M Lin
INTRODUCTION: Traumatic injury to the teeth can cause horizontal root fractures and inflammatory root resorptions (external and internal). Traditionally, traumatized teeth with horizontal root fractures resulting in pulp necrosis and inflammatory root resorptions are treated with conventional root canal therapy. METHODS: A 15-year-old boy had a history of traumatic injury to mature tooth #8 resulting in horizontal root fracture and pulp necrosis of the coronal fragment...
October 2016: Journal of Endodontics
Giselle D'Mello, Luke Moloney
Pulpal necrosis and infection in an immature anterior tooth subsequent to traumatic injury is a challenging situation. Regenerative endodontics, resulting in continued development of the tooth, provides a biological response to this clinical challenge. Regenerative endodontic procedures require disinfection of the infected root canal and sealing of the pulp canal space. Mineral trioxide aggregate (MTA) provides a good seal, is biocompatible, and allows the formation of a hard tissue to occur within the root canal...
August 24, 2016: Australian Dental Journal
Mohammad Ali Saghiri, Armen Asatourian, Franklin Garcia-Godoy, Nader Sheibani
This review intended to provide an overview of the effects of dental materials, used in dentin-pulp complex and dental pulp regeneration, on angiogenesis processes during regenerative endodontic procedures. An electronic search was performed in PubMed and MEDLINE databases via OVID using the keywords mentioned in the PubMed and MeSH headings for English language published articles from January 2005-April 2014 that evaluated the angiogenic properties of different dental materials used in regenerative endodontic procedures...
October 1, 2016: Dental Materials Journal
Reza Vahid Roudsari, Sarra Jawad, Carly Taylor, James Darcey, Alison Qualtrough
Although the principles of endodontics have remained unchanged for many decades, root canal treatment has been subject to major changes in the past few years. This paper outlines the cutting-edge advances including the materials and techniques used. CPD/Clinical Relevance: This article provides an overview of bioactive materials and insight into regenerative endodontics, vital pulp therapy and intentional replantation.
June 2016: Dental Update
Craig Bellamy, Suja Shrestha, Calvin Torneck, Anil Kishen
INTRODUCTION: This 2-part study hypothesized that a bioactive scaffold containing a sustained transforming growth factor (TGF)-β1-releasing nanoparticle system will promote migration and enhance differentiation of stem cells from the apical papilla (SCAP). The study aimed to develop and characterize a novel modified chitosan-based scaffold containing TGF-β1-releasing chitosan nanoparticles (TGF-β1-CSnp) to enhance migration and differentiation of SCAP. METHODS: Part I concerns the synthesis and characterization of a carboxymethyl chitosan-based scaffold and TGF-β1-CSnp...
September 2016: Journal of Endodontics
Gamze Topçuoğlu, Hüseyin Sinan Topçuoğlu
This report describes 3 successful single-visit regenerative endodontic therapy cases using platelet-rich plasma (PRP) and Biodentine (Septodont, Saint Maurdes Fossés, France) for 3 immature mandibular molar teeth, all with necrotic pulp, in 2 children aged 8 years and 1 aged 9 years. Three teeth were separately diagnosed as having a necrotic pulp. After preparation of the access cavity under rubber dam isolation, the necrotic pulp was removed, and each canal was irrigated with 2.5% sodium hypochlorite, sterile saline, and 17% EDTA solutions...
September 2016: Journal of Endodontics
Mina D Fahmy, Paul G Luepke, Mohamed S Ibrahim, Arndt Guentsch
Case Description. This case report describes the successful management of a left mandibular first molar with a combined periodontic-endodontic lesion in a 35-year-old Caucasian woman with aggressive periodontitis using a concerted approach including endodontic treatment, periodontal therapy, and a periodontal regenerative procedure using an enamel matrix derivate. In spite of anticipated poor prognosis, the tooth lesion healed. This case report also discusses the rationale behind different treatment interventions...
2016: Case Reports in Dentistry
Jason Latham, Hanson Fong, Anahid Jewett, James D Johnson, Avina Paranjpe
INTRODUCTION: The lack of mechanical debridement and reduced concentrations suggested for chemical debridement to maintain stem cell viability call into question the disinfection efficacy of current regenerative protocols. Current protocols vary in the concentration and type of antibiotic medicaments used. The aim of this study was to determine if simulated immature teeth infected with Enterococcus faecalis can be completely disinfected by following current standardized regenerative protocols and to evaluate the probable effects of residual bacteria on stem cell toxicity...
August 2016: Journal of Endodontics
Daniel B Jenks, Ygal Ehrlich, Kenneth Spolnik, Richard L Gregory, Ghaeth H Yassen
OBJECTIVE: We investigated the residual antibiofilm effects of different concentrations of double antibiotic paste (DAP) applied on radicular dentin for 1 or 4 weeks. DESIGN: Dentin samples were prepared (n=120), sterilized and pretreated for 1 or 4 weeks with the clinically used concentration of DAP (500mg/mL), low concentrations of DAP (1, 5 or 50mg/mL) loaded into a methylcellulose system, calcium hydroxide (Ca(OH)2), or placebo paste. After the assigned treatment time, treatment pastes were rinsed off and the samples were kept independently in phosphate buffered saline for 3 weeks...
June 7, 2016: Archives of Oral Biology
M A Alghilan, L J Windsor, J Palasuk, G H Yassen
AIM: To investigate the attachment and proliferation of dental pulp stem cells (DPSC) on dentine treated with various endodontic regeneration protocols. METHODOLOGY: Standardized dentine samples were irrigated with sodium hypochlorite (1.5% NaOCl) and ethylenediaminetetraacetic acid (17% EDTA) and randomized into four treatment groups and two control groups. The treatment groups were treated with a clinically used concentration of triple antibiotic paste (TAP), double antibiotic paste (DAP), calcium hydroxide (Ca(OH)2 ) or diluted TAP in a methylcellulose system (DTAP) for 1 week...
June 8, 2016: International Endodontic Journal
Sagar N Kaushik, Bogeun Kim, Alexander M Cruz Walma, Sung Chul Choi, Hui Wu, Jeremy J Mao, Ho-Wook Jun, Kyounga Cheon
Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem cells, signaling molecules, and scaffolds. In addition, clinical success of the regenerative endodontic treatments can be evidenced by absence of signs and symptoms; no bony pathology, a disinfected pulp, and the maturation of root dentin in length and thickness. In spite of the various approaches of regenerative endodontics, there are several major challenges that remain to be improved: a) the endodontic root canal is a strong harbor of the endodontic bacterial biofilm and the fundamental etiologic factors of recurrent endodontic diseases, (b) tooth discolorations are caused by antibiotics and filling materials, (c) cervical root fractures are caused by endodontic medicaments, (d) pulp tissue is not vascularized nor innervated, and (e) the dentin matrix is not developed with adequate root thickness and length...
2016: Biomaterials Research
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