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Regenerative endodontic

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https://www.readbyqxmd.com/read/28814182/regenerative-endodontics
#1
Kristina Feigin, Bonnie Shope
Regenerative endodontics has been defined as "biologically based procedure designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex." This is an exciting and rapidly evolving field of human endodontics for the treatment of immature permanent teeth with infected root canal systems. These procedures have shown to be able not only to resolve pain and apical periodontitis but continued root development, thus increasing the thickness and strength of the previously thin and fracture-prone roots...
September 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28781091/dental-pulp-stem-cells-their-potential-in-reinnervation-and-angiogenesis-by-using-scaffolds
#2
Ivo Lambrichts, Ronald B Driesen, Yörg Dillen, Pascal Gervois, Jessica Ratajczak, Tim Vangansewinkel, Esther Wolfs, Annelies Bronckaers, Petra Hilkens
Dental pulp is a highly vascularized and innervated tissue containing a heterogeneous stem cell population with multilineage differentiation potential. Current endodontic treatments focus on the preservation of the pulp tissue and the regeneration of dental pulp after pathological insults. Human dental pulp stem cells (hDPSCs) are currently investigated as stem cell-based therapy for pulp regeneration and for peripheral nerve injury in which neurons and Schwann cells display limited regenerative capacity. We have developed a neuronal differentiation protocol for hDPSCs that requires neurosphere formation before neuronal maturation...
August 3, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28765825/comparison-of-the-effect-of-prp-prf-and-induced-bleeding-in-the-revascularization-of-teeth-with-necrotic-pulp-and-open-apex-a-triple-blind-randomized-clinical-trial
#3
Vasundara Yayathi Shivashankar, Dexton Antony Johns, Ramesh Kumar Maroli, Mahalaxmi Sekar, Rathinavel Chandrasekaran, Shanmugavel Karthikeyan, Senthil Kumar Renganathan
INTRODUCTION: Treatment of a tooth with necrotic pulp and open apex is a special challenge to the clinicians. Apexification with calcium hydroxide and MTA barrier technique fails to induce continued root maturation which makes the tooth susceptible to root fracture. Hence, an ideal outcome for such a tooth should be regeneration of pulp like tissue into the root canal capable of continuing normal root maturation. AIM: This study aims to compare the effect of Platelet Rich Fibrin (PRF), induced bleeding technique and Platelet Rich Plasma (PRP) in the revascularization of tooth with necrotic pulp and open apex...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28764303/surgical-management-of-a-separated-endodontic-instrument-using-second-generation-platelet-concentrate-and-hydroxyapatite
#4
S L Satheesh, Shefali Jain, Atul Chandra Bhuyan, Lekshmy S Devi
Fractured endodontic instrument is an unfortunate endodontic mishap which may obstruct thorough cleaning and shaping of the root canals with potential impact on the endodontic prognosis and treatment outcome. When the fractured segment lies apical to canal curvature, overzealous removal of tooth structure is required to gain access to the separated segment which in turn increases the likelihood of root fracture. In infected cases, the stage at which instrument separation occurs is crucial as root canal disinfection is jeopardized...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28757246/evaluation-of-mesenchymal-stem-cell-modulation-of-trigeminal-neuronal-responses-to-cold
#5
Michael A Eskander, Koyo Takimoto, Anibal Diogenes
Tissue engineering protocols, such as regenerative endodontic procedures (REPs), comprise biologically based procedures designed to restore normal physiologic function. For REPs, the goal is reconstitution of the pulp-dentin complex by delivering mesenchymal stem cells (MSCs), including the stem cells of the apical papilla (SCAP) into a root canal system. Many patients regain cold sensitivity after REPs, but the mechanism is not understood. We hypothesized that SCAP modulate nociceptive function through a paracrine mechanism that activates cold-sensitive ion channels in neurons...
July 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/28751918/cellular-responses-in-human-dental-pulp-stem-cells-treated-with-three-endodontic-materials
#6
Alejandro Victoria-Escandell, José Santiago Ibañez-Cabellos, Sergio Bañuls-Sánchez de Cutanda, Ester Berenguer-Pascual, Jesús Beltrán-García, Eva García-López, Federico V Pallardó, José Luis García-Giménez, Antonio Pallarés-Sabater, Ignacio Zarzosa-López, Manuel Monterde
Human dental pulp stem cells (HDPSCs) are of special relevance in future regenerative dental therapies. Characterizing cytotoxicity and genotoxicity produced by endodontic materials is required to evaluate the potential for regeneration of injured tissues in future strategies combining regenerative and root canal therapies. This study explores the cytotoxicity and genotoxicity mediated by oxidative stress of three endodontic materials that are widely used on HDPSCs: a mineral trioxide aggregate (MTA-Angelus white), an epoxy resin sealant (AH-Plus cement), and an MTA-based cement sealer (MTA-Fillapex)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28743431/regenerative-endodontic-therapy-in-the-management-of-nonvital-immature-permanent-teeth-a-systematic-review-outcome-evaluation-and-meta-analysis
#7
REVIEW
Huei Jinn Tong, Sadna Rajan, Nabina Bhujel, Jing Kang, Monty Duggal, Hani Nazzal
INTRODUCTION: Although the protocols in previously published studies appeared to be largely similar, there were inadequate evidence-based guidelines to support a single protocol. Using a meta-analysis, this systematic review aimed to summarize and quantitatively evaluate the outcomes for nonvital immature permanent teeth treated using the regenerative endodontic technique (RET) as well as critically appraise the level and quality of evidence of the existing publications. METHODS: Risk of bias assessment and level of evidence grading were performed on all included studies...
July 22, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28716215/clinical-and-radiographic-assessment-of-the-efficacy-of-a-collagen-membrane-in-regenerative-endodontics-a-randomized-controlled-clinical%C3%A2-trial
#8
Xijun Jiang, He Liu, Chufang Peng
INTRODUCTION: Recent reviews confirm a general lack of randomized, controlled clinical studies on the efficacy of regenerative endodontics in immature teeth affected by pulp and periapical diseases. Moreover, we have no evidence of the curative efficacy of collagen membranes used as scaffolds in regenerative endodontics. Here, we evaluated whether a Bio-Gide collagen membrane (Geistlich Pharma AG, Wolhusen, Switzerland) has efficacy in promoting dentin formation in regenerative endodontics...
July 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28712637/treatment-options-for-failing-regenerative-endodontic-procedures-report-of-3-cases
#9
Antonis Chaniotis
INTRODUCTION: Regenerative treatments in necrotic immature teeth are suggested as alternatives to conventional multiple or single-step apexification procedures. Although case reports and case series provide promising results, the treatment protocol is not yet fully established and regenerative procedure might fail. Once failure is encountered, the apexification treatment options still remain. METHODS: Repetition of the regenerative procedure after initial revitalization failure has not been suggested yet...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28691752/mineral-trioxide-aggregate-improves-healing-response-of-periodontal-tissue-to-injury-in-mice
#10
I Vidovic Zdrilic, I O de Azevedo Queiroz, B G Matthews, J E Gomes-Filho, M Mina, I Kalajzic
BACKGROUND AND OBJECTIVE: Mineral trioxide aggregate (MTA) is a biomaterial used in endodontic procedures as it exerts beneficial effects on regenerative processes. In this study, we evaluate the effect of MTA on healing of periodontal ligament (PDL) and surrounding tissue, following injury, in a transgenic mouse model and on the differentiation of murine mesenchymal progenitor cells in vitro. MATERIAL AND METHODS: We used an inducible Cre-loxP in vivo fate mapping approach to examine the effects of MTA on the contributions of descendants of cells expressing the αSMA-CreERT2 transgene (SMA9(+) ) to the PDL and alveolar bone after experimental injury to the root furcation on the maxillary first molars...
July 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28672895/role-of-transient-receptor-potential-channel-6-in-the-odontogenic-differentiation-of-human-dental-pulp-cells
#11
Xiaoting Yang, Zhi Song, Lingling Chen, Runfu Wang, Shuheng Huang, Wei Qin, Jia Guo, Zhengmei Lin
Pulp capping is a restorative technique employed in an attempt to maintain pulpal vitality and generate reparative dentin. Ca(2+) released from capping materials is suggested to promote reparative dentin formation. Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca2+ channel that serves an important role in Ca2+ influx in the majority of non-excitable cells, and influences the calcium signaling and cell respond. Therefore, the purpose of the present study was to gain an insight into the role of TRPC6 in the odontoblastic differentiation of human dental pulp cells (HDPCs)...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28667922/combination-of-hydroxyapatite-platelet-rich-fibrin-and-amnion-membrane-as-a-novel-therapeutic-option-in-regenerative-periapical-endodontic-surgery-case-series
#12
Uday Kiran Uppada, Butchibabu Kalakonda, Pradeep Koppolu, Narendra Varma, Kiran Palakurthy, Venkatesh Manchikanti, Shilpa Prasad, Shereen Samar, Lingam Amara Swapna
INTRODUCTION: Periapical surgery is the last resort in the arsenal of an endodontist to effectively deal with periapical lesions that result from necrosis of the pulp. Bone grafts, growth factors and membranes form an array of regenerative materials that influence the healing outcome of periapical surgery. PRESENTATION OF CASE: The main purpose of the two cases reported here was to assess the potential benefits of a combination of bone graft, platelet-rich fibrin (PRF) and amnion membrane in terms of reduced post-operative discomfort, radiographic evidence of accelerated periapical bone healing and present a novel therapeutic option in the management of large periapical lesions...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28662879/use-of-platelet-rich-plasma-in-endodontic-procedures-in-adults-regeneration-or-repair-a-report-of-3-cases-with-5%C3%A2-years-of-follow-up
#13
José Francisco Gaviño Orduña, Javier Caviedes-Bucheli, María C Manzanares Céspedes, Esther Berástegui Jimeno, Benjamín Martín Biedma, Juan José Segura-Egea, José López-López
INTRODUCTION: Regenerative endodontic procedures (REP) are a promising alternative for necrotic immature teeth in adolescents and children, but very little evidence is available on this alternative in long-lasting necrotic teeth with open apices in adults. REPs are designed to replace damaged structures of the pulp-dentin complex, but no regeneration has been obtained in any of the cases described in necrotic immature permanent teeth with apical periodontitis with histologic results. The results are limited to periapical tissue repair with increasing root length, thickening of the root walls, and apical closure in young patients...
August 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28656722/formation-of-spheroids-by-dental-pulp-derived-cells-in-the-presence-of-hypoxia-and-hypoxia-mimetic-agents
#14
K Janjić, B Lilaj, A Moritz, H Agis
AIM: To evaluate the impact of hypoxia and hypoxia mimetic agents (HMA) on the formation and activity of spheroids by dental pulp-derived cells (DPC). METHODOLOGY: DPC on agarose-coated plates were treated with hypoxia and the HMA dimethyloxallyl glycine (DMOG), desferrioxamine (DFO) and L-mimosine (L-MIM). Images of spheroids were taken directly after seeding and at 6h and 24h. Spheroid sizes were quantified by area measurement with ImageJ software. Viability was assessed with Live-Dead staining, MTT and resazurin-based toxicity assay...
June 28, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28653761/a-prospective-clinical-study-of-regenerative-endodontic-treatment-of-traumatized-immature-teeth-with-necrotic-pulps-using-bi-antibiotic-paste
#15
H Nazzal, K Kenny, A Altimimi, J Kang, M S Duggal
AIM: To evaluate the treatment outcomes of a revitalization endodontic technique (RET) for the management of traumatized immature teeth with necrotic pulps in children. METHODOLOGY: Fifteen healthy children (age range = 7-10 years) with traumatized immature maxillary incisors with necrotic pulps treated with bi-antibiotic revitalization endodontic technique were prospectively assessed over approximately two years (mean = 22 months). One operator undertook all treatments, clinical reviews and standardized radiographic exposures with radiographic analysis being carried out by two calibrated experienced clinicians...
June 27, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28616672/biological-effects-of-silk-fibroin-3d-scaffolds-on-stem-cells-from-human-exfoliated-deciduous-teeth-sheds
#16
M Collado-González, M P Pecci-Lloret, D García-Bernal, S Aznar-Cervantes, R E Oñate-Sánchez, J M Moraleda, J L Cenis, F J Rodríguez-Lozano
The aim is to investigate in vitro biological effects of silk fibroin 3D scaffolds on stem cells from human exfoliated deciduous teeth (SHEDs) in terms of proliferation, morphological appearance, cell viability, and expression of mesenchymal stem cell markers. Silk fibroin 3D scaffolding materials may represent promising suitable scaffolds for their application in regenerative endodontic therapy approaches. SHEDs were cultured in silk fibroin 3D scaffolds. Then, cell numbers were counted and the Alamar blue colorimetric assay was used to analyse cell proliferation after 24, 48, 72, and 168 h of culture...
June 14, 2017: Odontology
https://www.readbyqxmd.com/read/28583238/regenerative-endodontic-treatment-of-necrotic-primary-molars-with-missing-premolars-a-case-series
#17
Ayca T Ulusoy, Zafer C Cehreli
The endodontic treatment of necrotic primary teeth with missing successors presents a unique clinical challenge. The purpose of this report was to describe the clinical and radiological outcomes of regenerative endodontic treatment (revascularization) of necrotic primary molars. Four infected necrotic primary second molars with missing premolars were treated with a two-visit revascularization protocol. The crowns were restored with amalgam or acid-etch composite resin. The teeth were followed-up clinically and radiographically for 18 months...
May 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28578888/comparative-evaluation-of-chemotactic-factor-effect-on-migration-and-differentiation-of-stem-cells-of-the-apical-papilla
#18
Sara Fayazi, Koyo Takimoto, Anibal Diogenes
INTRODUCTION: Cell homing strategies could potentially be used in regenerative endodontic procedures (REPs) to promote the progressive coronal migration of stem cells, including stem cells of the apical papilla (SCAPs), along with formation of a new vascular network without the need for intentional apical trauma and intracanal bleeding. Although many chemotactic factors have been investigated for different mesenchymal stem cells, their effect on SCAP migration and differentiation is not fully understood...
June 1, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28577961/histologic-evaluation-of-regenerative-endodontic-procedures-with-the-use-of-chitosan-scaffolds-in-immature-dog-teeth-with-apical-periodontitis
#19
Paulo J Palma, João C Ramos, João B Martins, Anibal Diogenes, Maria H Figueiredo, Paula Ferreira, Carlos Viegas, João M Santos
INTRODUCTION: The aim of this study was to evaluate histologically the newly formed tissues after regenerative endodontic procedures (REPs) in dogs using either a blood clot (BC) or 2 different formulations of a chitosan hydrogel as scaffolds. METHODS: Apical periodontitis was induced by inoculating immature teeth with oral plaque in 4 beagle dogs. Teeth (n = 96) were divided into 2 control (n = 20) and 4 test groups (n = 76) according to the treatment: apexification and REPs with BC, sodium hyaluronate:chitosan (HA:CS) scaffolds, or pectin:chitosan (P:CS) scaffolds...
May 31, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28568134/lysyl-oxidase-mediated-vegf-induced-differentiation-and-angiogenesis-in-human-dental-pulp-cells
#20
W J Bae, J K Yi, J Park, S K Kang, J H Jang, E C Kim
AIM: To investigate the effects of recombinant human vascular endothelial growth factor (rhVEGF) on odontoblastic differentiation, in vitro angiogenesis, and expression and activity of lysyl oxidase (LOX) in human dental pulp cells (HDPCs), compared with rhFGF-2. To identify the underlying molecular mechanisms, the study focused on whether LOX was responsible for the actions of rhVEGF. METHODOLOGY: rhVEGF was constructed using the pBAD-HisA plasmid in Escherichia coli...
June 1, 2017: International Endodontic Journal
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