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Regenerative endodontic

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https://www.readbyqxmd.com/read/29440793/use-of-an-amniotic-membrane-as-a-novel-barrier-in-a-tooth-with-a-questionable-prognosis
#1
Kanakamedala Anil Kumar, Muppalla Chakravarthy, Shalini Selvarajan, Theyagarajan Ramakrishnan, Geetha Ari
The chief goal of combination therapy using guided tissue regeneration along with bone grafts is to optimally and predictably regenerate the periodontal attachment apparatus. The evolution of regenerative therapy along with careful patient selection and treatment planning can have positive results even in cases which are not ideal. The present case report describes a tooth with a questionable prognosis treated successively by endodontic then periodontal therapy using an amniotic membrane along with a bone graft to treat an intrabony defect...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29399304/the-effect-of-photobiomodulation-on-the-depth-of-anesthesia-during-endodontic-treatment-of-teeth-with-symptomatic-irreversible-pulpitis-double-blind-randomized-clinical-trial
#2
Sholeh Ghabraei, Nasim Chiniforush, Behnam Bolhari, Mohsen Aminsobhani, Abbas Khosarvi
Introduction: Achieving appropriate anesthesia in patients with symptomatic irreversible pulpitis in mandibular molars during endodontic treatment is always one of the most challenging aspects. Photobiomodulation (PBM) has been used in dentistry due to its anti-inflammatory properties and regenerative effects. This study evaluates the effects of PBM in the depth of anesthesia in inferior alveolar nerve block. Methods: In this randomized clinical trial, 44 patients requiring endodontic treatment in lower molar, left or right were selected, half of them were randomly treated with PBM therapy...
2018: Journal of Lasers in Medical Sciences
https://www.readbyqxmd.com/read/29386790/use-of-bovine-colostrum-in-periapical-defects-following-surgical-endodontics-two-case-reports
#3
Chandrasekhar Veeramachaneni, Ch Gayathri, Abhijeet K Kakani, R Mohini
Periapical lesions are the most common pathological conditions involving teeth which often require surgical intervention. To achieve optimal healing both clinically and radiographically, bone grafts and barrier membranes have been used to fill the periapical defect after degranulation of the lesion. Colostrum is one of the new materials, which has osteoinductive or regenerative potential. The present case reports describe the use of bovine colostrum in the treatment of periapical inflammatory lesion with a follow-up period of 12 months...
September 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29336522/continued-root-maturation-despite-persistent-apical-periodontitis-of-immature-permanent-teeth-after-failed-regenerative-endodontic-therapy
#4
Louis M Lin, Sahng G Kim, Gabriela Martin, Bill Kahler
Three immature permanent teeth with pulp necrosis and apical periodontitis were treated with regenerative endodontic therapy (RET), which included root canal disinfection with sodium hypochlorite irrigation, intra-canal medication with calcium hydroxide paste, 17% EDTA rinse, induction of periapical bleeding into the canal, collagen matrix and MTA coronal seal, and composite resin restoration of access cavities. After different periods of follow-up, it was observed that continued root maturation, especially apical closure occurred despite persistent apical periodontitis of immature permanent teeth after failed RET...
January 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29306537/metformin-enhances-the-differentiation-of-dental-pulp-cells-into-odontoblasts-by-activating-ampk-signaling
#5
Wei Qin, Xianling Gao, Tao Ma, Michael D Weir, Jing Zou, Bing Song, Zhengmei Lin, Abraham Schneider, Hockin H K Xu
INTRODUCTION: Metformin is a first-line drug for treating type 2 diabetes that regulates the differentiation of mesenchymal stem cells. Its effects on human dental pulp cells (DPCs) remain unknown. This study aimed to investigate the effects of metformin on the proliferation and differentiation of DPCs. METHODS: A live/dead viability assay kit was used to examine the effects of metformin on the cell viability of DPCs. Cell proliferation was analyzed using a cell counting kit (CCK-8; Dojindo, Tokyo, Japan)...
January 3, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29306536/orthodontic-movement-after-regenerative-endodontic-procedure-case-report-and-long-term-observations
#6
Antonis Chaniotis
INTRODUCTION: Although regenerative treatment approaches in teeth with incomplete root formation and pulp necrosis have become part of the suggested therapeutic endodontic spectrum, little is known about the effect of orthodontic movement in the tissue that has been regenerated. Furthermore, as the number of adults undergoing orthodontic treatment increases, there is an increasing need to investigate the changes that these tissues may undergo during orthodontic movement. Here we describe the alterations observed after the application of orthodontic forces in a case of an apically root-fractured necrotic immature root that had been managed with regenerative endodontic procedures in the past...
January 3, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29275851/biocompatibility-and-osteogenic-calcification-potential-of-casein-phosphopeptide-amorphous-calcium-phosphate-fluoride
#7
Alaa E Dawood, David J Manton, Peter Parashos, Rebecca H Wong, William Singleton, James A Holden, Neil M O'Brien-Simpson, Eric C Reynolds
INTRODUCTION: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and CPP-ACP with fluoride (CPP-ACFP) have been shown to provide bioavailable ions to promote mineralization. Hence, the aim of this study was to evaluate the materials' biocompatibility and osteogenic/calcification potential for endodontic applications. METHODS: Human and mouse osteoblast-like and fibroblast-like cell lines were incubated with 0.05%-3.0% w/v CPP-ACP and CPP-ACFP, and toxicity, proliferation, alkaline phosphatase, interleukin (IL)-1α, and IL-6 production, collagen type I, osteocalcin, and osteopontin production, and mineralization/calcification were determined...
December 21, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29275849/management-of-intruded-immature-maxillary-central-incisor-with-pulp-necrosis-and-severe-external-resorption-by-regenerative-approach
#8
Giorgos N Tzanetakis
INTRODUCTION: Intrusive luxation is one of the most severe traumatic injuries of permanent teeth that may adversely affect the pulp and the periodontium. Pulp necrosis and root resorption are the main pathologic entities associated with this injury. The present report describes the endodontic management of an intruded immature maxillary central incisor presented with pulp necrosis and severe inflammatory root resorption by using the regenerative approach. METHODS: A 7-year-old boy with dental trauma to the anterior maxillary region was referred for the management of a traumatized maxillary central incisor...
December 21, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29273495/influence-of-apical-diameter-on-the-outcome-of-regenerative-endodontic-treatment-in-teeth-with-pulp-necrosis-a-review
#9
REVIEW
Yanjun Fang, Xinhuan Wang, Jingjing Zhu, Chaonan Su, Ying Yang, Liuyan Meng
INTRODUCTION: The aim of this review was to evaluate whether the apical diameter of teeth with necrotic pulp affects the outcomes of regenerative endodontic treatment and to determine the minimal apical size needed to obtain proper pulp revascularization. METHODS: A literature search was performed from January 1, 2001, to November 25, 2016. Studies that satisfied the inclusion criteria were subjected to data extraction and analysis. RESULTS: In total, 14 studies with 85 patients were included...
December 19, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29229459/regenerative-endodontic-procedures-among-endodontists-a-web-based-survey
#10
Jonathan Y Lee, Daniel D Kersten, Pete Mines, Thomas A Beltran
INTRODUCTION: The protocols that endodontists implement for regenerative endodontic procedures (REPs) are unknown. The aim of this study was to examine current REP protocols among practicing endodontists in the United States. METHODS: A Web-based survey was sent to 4060 active members of the American Association of Endodontists (AAE). A total of 850 participants completed the survey, representing a 20.9% response rate. RESULTS: Responses indicated 60% reported having performed REPs; most performed 1 to 3 per year...
December 8, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29206139/alkaline-materials-and-regenerative-endodontics-a-review
#11
REVIEW
Bill Kahler, Nadia Chugal, Louis M Lin
Periapical health is the primary goal of endodontic treatment in mature and immature teeth. In addition, the goals of treatment of immature teeth with arrested root development include root growth to length and maturation of the apex, as well as thickening of the canal wall. These goals are valid for immature teeth that have been subjected to trauma and dental caries or that are the result of developmental anomalies that expose the tooth to the risk of pulp necrosis and consequently result in the cessation of root maturation...
December 5, 2017: Materials
https://www.readbyqxmd.com/read/29197101/a-biocompatible-decellularised-pulp-scaffold-for-regenerative-endodontics
#12
M Matoug-Elwerfelli, M S Duggal, H Nazzal, F Esteves, E Raïf
AIM: To investigate the feasibility of decellularising the entire dental pulp using a mild treatment protocol to develop a decellularised biological extracellular matrix scaffold for use in regenerative endodontic procedures. METHODOLOGY: Decellularised human dental pulps were assessed using histological and immunohistochemical methods, scanning electron microscope and DNA quantification assay. Cytotoxicity assays to determine decellularised scaffold biocompatibility were also performed...
December 1, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/29090391/prevention-of-coronal-discoloration-induced-by-regenerative-endodontic-treatment-in-an-ex-vivo-model
#13
Noushin Shokouhinejad, Mehrfam Khoshkhounejad, Marzieh Alikhasi, Parisa Bagheri, Josette Camilleri
OBJECTIVES: The aim of this study was to assess the effect of sealing the pulp chamber walls with a dentin-bonding agent (DBA) on prevention of discoloration induced by regenerative endodontic procedures (REPs) in an ex vivo model. MATERIALS AND METHODS: Ninety-six bovine incisors were prepared and randomly divided into two groups. In one group, the pulp chamber walls were sealed with DBA before placement of triple antibiotic paste (TAP) containing minocycline inside the root canals, but in the other group, DBA was not applied...
October 31, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29079055/bleaching-of-a-discolored-tooth-with-retrieval-of%C3%A2-remnants-after-successful-regenerative-endodontics
#14
Aovana Timmerman, Peter Parashos
INTRODUCTION: This report presents the retrieval of remnants from a discolored mandibular right second premolar (tooth #29) of a 17-year-old female after a successful regenerative endodontic procedure (REP). METHODS: The REP was performed in October 2011. Coronal discoloration became of great concern to the patient at a review visit in 2016. A cone-beam computed tomographic scan was taken to investigate the formation of hard tissues within the root canal as well as a region of no calcified tissue formation...
October 24, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29075537/pulpo-periodontal-regeneration-management-of-partial-failure-revascularization
#15
Said Dhaimy, Sara Dhoum, Hind Amarir, Hafsa El Merini, Sellama Nadifi, Amal El Ouazzani
The aim of this work is to present a case of management of an open apex on a lower molar by using tissue engineering, with two endodontic procedures in the same tooth. We had to resort to pulp regeneration on the distal root and apexification with MTA on the mesial roots after the failure of regenerative therapy on those ones. The management consisted in scheduling regular follow-ups combined with X-rays. After 24 months, the radiological control has shown pulpo-periodontal regeneration associated with walls thickening and distal root elongation and periapical ad integrum healing...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29061356/clindamycin-modified-triple-antibiotic-nanofibers-a-stain-free-antimicrobial-intracanal-drug-delivery-system
#16
Ashley Karczewski, Sabrina A Feitosa, Ethan I Hamer, Divya Pankajakshan, Richard L Gregory, Kenneth J Spolnik, Marco C Bottino
INTRODUCTION: A biocompatible strategy to promote bacterial eradication within the root canal system after pulpal necrosis of immature permanent teeth is critical to the success of regenerative endodontic procedures. This study sought to synthesize clindamycin-modified triple antibiotic (metronidazole, ciprofloxacin, and clindamycin [CLIN]) polymer (polydioxanone [PDS]) nanofibers and determine in vitro their antimicrobial properties, cell compatibility, and dentin discoloration. METHODS: CLIN-only and triple antibiotic CLIN-modified (CLIN-m, minocycline-free) nanofibers were processed via electrospinning...
October 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29047120/dental-pulp-regeneration-via-cell-homing
#17
REVIEW
S Eramo, A Natali, R Pinna, E Milia
The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/regeneration, which is more clinically translatable. This systematic review examines cell homing for dental pulp regeneration, selecting articles on in vitro experiments, in vivo ectopic transplantation models and in situ pulp revascularization...
October 19, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/29034570/efficacy-of-different-carriers-for-the-triple-antibiotic-powder-during-regenerative-endodontic-procedures
#18
David Hwang, Hanson Fong, James D Johnson, Avina Paranjpe
Chemical debridement during Regenerative Endodontic procedures is important. Previous research studies have evaluated various antibiotics and their concentrations but none have addressed the concern of delivering these materials. Hence, the purpose of this study was to determine what carrier could be used effectively in a clinical setting. Sixty caries-free maxillary incisors were used and inoculated with Enterococcus faecalis and divided into positive and irrigation controls and experimental groups that had triple antibiotic powder (1:1:1 ciprofloxacin:metronidazole:minocycline) delivered using various carriers: saline, cotton, sponge and methylcellulose...
October 16, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29032818/radiographic-histologic-and-biomechanical-evaluation-of-combined-application-of%C3%A2-platelet-rich-fibrin-with-blood-clot-in%C3%A2-regenerative-endodontics
#19
Ronghui Zhou, Yumin Wang, Yuemin Chen, Shuai Chen, Hongbing Lyu, Zhiyu Cai, Xiaojing Huang
INTRODUCTION: No in vivo study has been reported on the mechanical reinforcement of a tooth after regenerative endodontic treatment (RET). The present work aimed to evaluate the concurrent use of platelet-rich fibrin (PRF) with a blood clot (BC) in RET concerning periapical healing, root development, and tooth structural reinforcement. METHODS: In our study, 24 premolars from 3 beagle dogs were assigned into control, BC, and PRF + BC groups. Periapical healing was monitored with quantitative measurements of root elongation and thickening radiographically...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28965773/an-innovative-regenerative-endodontic-procedure-using-leukocyte-and-platelet-rich-fibrin-associated-with-apical-surgery-a%C3%A2-case%C3%A2-report
#20
Nelson Pinto, Alexandra Harnish, Carolina Cabrera, Catherine Andrade, Tony Druttman, Claudia Brizuela
Regenerative endodontic procedures (REPs) associated with apical surgery could represent an alternative treatment strategy for patients whose teeth present incomplete root formation and extensive apical lesions. Leukocyte platelet-rich fibrin (L-PRF) has potential benefits in REPs; it could promote apical root formation and optimal bone healing. The aim of this case report was to describe innovative regenerative endodontic therapy using L-PRF in the root canal and an extensive apical lesion in an immature tooth with dens invaginatus and asymptomatic apical periodontitis...
November 2017: Journal of Endodontics
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