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Regenerative endodontic

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https://www.readbyqxmd.com/read/29206139/alkaline-materials-and-regenerative-endodontics-a-review
#1
REVIEW
Bill Kahler, Nadia Chugal, Louis M Lin
Periapical health is the primary goal of endodontic treatment in mature and immature teeth. In addition, the goals of treatment of immature teeth with arrested root development include root growth to length and maturation of the apex, as well as thickening of the canal wall. These goals are valid for immature teeth that have been subjected to trauma and dental caries or that are the result of developmental anomalies that expose the tooth to the risk of pulp necrosis and consequently result in the cessation of root maturation...
December 5, 2017: Materials
https://www.readbyqxmd.com/read/29197101/a-biocompatible-decellularised-pulp-scaffold-for-regenerative-endodontics
#2
M Matoug-Elwerfelli, M S Duggal, H Nazzal, F Esteves, E Raïf
AIM: To investigate the feasibility of decellularising the entire dental pulp using a mild treatment protocol to develop a decellularised biological extracellular matrix scaffold for use in regenerative endodontic procedures. METHODOLOGY: Decellularised human dental pulps were assessed using histological and immunohistochemical methods, scanning electron microscope and DNA quantification assay. Cytotoxicity assays to determine decellularised scaffold biocompatibility were also performed...
December 1, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/29090391/prevention-of-coronal-discoloration-induced-by-regenerative-endodontic-treatment-in-an-ex-vivo-model
#3
Noushin Shokouhinejad, Mehrfam Khoshkhounejad, Marzieh Alikhasi, Parisa Bagheri, Josette Camilleri
OBJECTIVES: The aim of this study was to assess the effect of sealing the pulp chamber walls with a dentin-bonding agent (DBA) on prevention of discoloration induced by regenerative endodontic procedures (REPs) in an ex vivo model. MATERIALS AND METHODS: Ninety-six bovine incisors were prepared and randomly divided into two groups. In one group, the pulp chamber walls were sealed with DBA before placement of triple antibiotic paste (TAP) containing minocycline inside the root canals, but in the other group, DBA was not applied...
October 31, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29079055/bleaching-of-a-discolored-tooth-with-retrieval-of%C3%A2-remnants-after-successful-regenerative-endodontics
#4
Aovana Timmerman, Peter Parashos
INTRODUCTION: This report presents the retrieval of remnants from a discolored mandibular right second premolar (tooth #29) of a 17-year-old female after a successful regenerative endodontic procedure (REP). METHODS: The REP was performed in October 2011. Coronal discoloration became of great concern to the patient at a review visit in 2016. A cone-beam computed tomographic scan was taken to investigate the formation of hard tissues within the root canal as well as a region of no calcified tissue formation...
October 24, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29075537/pulpo-periodontal-regeneration-management-of-partial-failure-revascularization
#5
Said Dhaimy, Sara Dhoum, Hind Amarir, Hafsa El Merini, Sellama Nadifi, Amal El Ouazzani
The aim of this work is to present a case of management of an open apex on a lower molar by using tissue engineering, with two endodontic procedures in the same tooth. We had to resort to pulp regeneration on the distal root and apexification with MTA on the mesial roots after the failure of regenerative therapy on those ones. The management consisted in scheduling regular follow-ups combined with X-rays. After 24 months, the radiological control has shown pulpo-periodontal regeneration associated with walls thickening and distal root elongation and periapical ad integrum healing...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29061356/clindamycin-modified-triple-antibiotic-nanofibers-a-stain-free-antimicrobial-intracanal-drug-delivery-system
#6
Ashley Karczewski, Sabrina A Feitosa, Ethan I Hamer, Divya Pankajakshan, Richard L Gregory, Kenneth J Spolnik, Marco C Bottino
INTRODUCTION: A biocompatible strategy to promote bacterial eradication within the root canal system after pulpal necrosis of immature permanent teeth is critical to the success of regenerative endodontic procedures. This study sought to synthesize clindamycin-modified triple antibiotic (metronidazole, ciprofloxacin, and clindamycin [CLIN]) polymer (polydioxanone [PDS]) nanofibers and determine in vitro their antimicrobial properties, cell compatibility, and dentin discoloration. METHODS: CLIN-only and triple antibiotic CLIN-modified (CLIN-m, minocycline-free) nanofibers were processed via electrospinning...
October 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29047120/dental-pulp-regeneration-via-cell-homing
#7
REVIEW
S Eramo, A Natali, R Pinna, E Milia
The typical treatment for irreversibly inflamed/necrotic pulp tissue is root canal treatment. As an alternative approach, regenerative endodontics aims to regenerate dental pulp-like tissues using two possible strategies: cell transplantation and cell homing. The former requires exogenously transplanted stem cells, complex procedures and high costs; the latter employs the host's endogenous cells to achieve tissue repair/regeneration, which is more clinically translatable. This systematic review examines cell homing for dental pulp regeneration, selecting articles on in vitro experiments, in vivo ectopic transplantation models and in situ pulp revascularization...
October 19, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/29034570/efficacy-of-different-carriers-for-the-triple-antibiotic-powder-during-regenerative-endodontic-procedures
#8
David Hwang, Hanson Fong, James D Johnson, Avina Paranjpe
Chemical debridement during Regenerative Endodontic procedures is important. Previous research studies have evaluated various antibiotics and their concentrations but none have addressed the concern of delivering these materials. Hence, the purpose of this study was to determine what carrier could be used effectively in a clinical setting. Sixty caries-free maxillary incisors were used and inoculated with Enterococcus faecalis and divided into positive and irrigation controls and experimental groups that had triple antibiotic powder (1:1:1 ciprofloxacin:metronidazole:minocycline) delivered using various carriers: saline, cotton, sponge and methylcellulose...
October 16, 2017: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29032818/radiographic-histologic-and-biomechanical-evaluation-of-combined-application-of%C3%A2-platelet-rich-fibrin-with-blood-clot-in%C3%A2-regenerative-endodontics
#9
Ronghui Zhou, Yumin Wang, Yuemin Chen, Shuai Chen, Hongbing Lyu, Zhiyu Cai, Xiaojing Huang
INTRODUCTION: No in vivo study has been reported on the mechanical reinforcement of a tooth after regenerative endodontic treatment (RET). The present work aimed to evaluate the concurrent use of platelet-rich fibrin (PRF) with a blood clot (BC) in RET concerning periapical healing, root development, and tooth structural reinforcement. METHODS: In our study, 24 premolars from 3 beagle dogs were assigned into control, BC, and PRF + BC groups. Periapical healing was monitored with quantitative measurements of root elongation and thickening radiographically...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28965773/an-innovative-regenerative-endodontic-procedure-using-leukocyte-and-platelet-rich-fibrin-associated-with-apical-surgery-a%C3%A2-case%C3%A2-report
#10
Nelson Pinto, Alexandra Harnish, Carolina Cabrera, Catherine Andrade, Tony Druttman, Claudia Brizuela
Regenerative endodontic procedures (REPs) associated with apical surgery could represent an alternative treatment strategy for patients whose teeth present incomplete root formation and extensive apical lesions. Leukocyte platelet-rich fibrin (L-PRF) has potential benefits in REPs; it could promote apical root formation and optimal bone healing. The aim of this case report was to describe innovative regenerative endodontic therapy using L-PRF in the root canal and an extensive apical lesion in an immature tooth with dens invaginatus and asymptomatic apical periodontitis...
November 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28962932/insufficient-evidence-about-outcomes-of-regenerative-endodontic-techniques
#11
Romina Brignardello-Petersen
No abstract text is available yet for this article.
September 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28905412/long-term-treatment-costs-for-aggressive-periodontitis-in-a-german-population
#12
Falk Schwendicke, Anne Sophie Biffar, Christian Graetz
AIM: This study assessed the long-term annual costs for treating aggressive periodontitis (AgP) patients. METHODS: A cohort of compliant AgP patients was retrospectively evaluated. Costs for active periodontal therapy (APT, including scaling and root planning, open flap debridement, root resections, but not pocket-elimination or regenerative surgery) and supportive periodontal therapy (SPT, including also costs for restorative, endodontic, prosthetic and surgical treatments) were estimated from a mixed payer-perspective in Germany...
September 14, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28864219/regenerative-endodontics-versus-apexification-in-immature-permanent-teeth-with-apical-periodontitis-a-prospective-randomized-controlled-study
#13
Jiacheng Lin, Qian Zeng, Xi Wei, Wei Zhao, Minyi Cui, Jing Gu, Jiaxuan Lu, Maobin Yang, Junqi Ling
INTRODUCTION: The aim of the study was to compare the outcomes of regenerative endodontic treatment (RET) and apexification on immature permanent teeth with pulp necrosis and apical periodontitis. METHODS: A total of 118 patients (118 teeth) were recruited and randomly assigned to either RET or apexification treatment. Each treatment group was divided into 2 subgroups according to the etiology: dens evaginatus or trauma. Clinical symptoms and complications were recorded, and cone-beam computed tomographic imaging with a limited field of view was used to measure the change of root length, root thickness, and apical foramen size at the 12-month follow-up...
November 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28846134/mineral-trioxide-aggregate-and-other-bioactive-endodontic-cements-an-updated-overview-part-ii-other-clinical-applications-and-complications
#14
REVIEW
M Torabinejad, M Parirokh, P M H Dummer
Mineral trioxide aggregate (MTA) is a dental material used extensively for vital pulp therapies (VPT), protecting scaffolds during regenerative endodontic procedures, apical barriers in teeth with necrotic pulps and open apices, perforation repairs as well as root canal filling and root-end filling during surgical endodontics. A number of bioactive endodontic cements (BECs) have recently been introduced to the market. Most of these materials have calcium and silicate in their compositions; however, bioactivity is a common property of these cements...
August 28, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28844309/microbial-modulation-of-stem-cells-and-future-directions-in-regenerative-endodontics
#15
Anibal Diogenes, Kenneth M Hargreaves
Regenerative endodontic procedures (REPs) have been shown to promote the resolution of signs and symptoms of disease and increase survival compared with traditional treatment procedures. However, there is still variable predictability of continued root development and evidence that the tissues formed do not recapitulate the native pulp-dentin complex. There is growing evidence that the apical papilla is capable of surviving prolonged endodontic infection and apical periodontitis and that it represents a rich source of undifferentiated mesenchymal stem cells in REPs...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28844308/inflammation-and-regeneration-in-the-dentin-pulp-complex-net-gain-or-net-loss
#16
Paul R Cooper, Ilaria J Chicca, Michael J Holder, Michael R Milward
The balance between the immune/inflammatory and regenerative responses in the diseased pulp is central to the clinical outcome, and this response is unique within the body because of its tissue site. Cariogenic bacteria invade the dentin and pulp tissues, triggering molecular and cellular events dependent on the disease stage. At the early onset, odontoblasts respond to bacterial components in an attempt to protect the tooth's hard and soft tissues and limit disease progression. However, as disease advances, the odontoblasts die, and cells central to the pulp core, including resident immune cells, pulpal fibroblasts, endothelial cells, and stem cells, respond to the bacterial challenge via their expression of a range of pattern recognition receptors that identify pathogen-associated molecular patterns...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28844307/clinical-evidence-for-regenerative-endodontic-procedures-immediate-versus-delayed-induction
#17
Tatiana M Botero, Xianli Tang, Richard Gardner, Jan C C Hu, James R Boynton, G Rex Holland
Clinicians face many challenges when treating immature permanent teeth in young patients. Immediate blood clot induction can be a successful option as described by some case reports. No experimental studies or clinical trials have addressed this question. We have designed a clinical trial in which we hypothesized that there is no difference in success between immediate or delayed induction protocols. After confirmation of pulpal necrosis, patients were randomized. In the delayed group, 15 teeth were treated following the American Association of Endodontists guidelines, and calcium hydroxide was used as the intracanal medication...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28844305/regenerative-endodontics-for-adult-patients
#18
Ling He, Sahng G Kim, Qimei Gong, Juan Zhong, Sainan Wang, Xuedong Zhou, Ling Ye, Junqi Ling, Jeremy J Mao
The goal of endodontics is to save teeth. Since inception, endodontic treatments are performed to obturate disinfected root canals with inert materials such as gutta-percha. Although teeth can be saved after successful endodontic treatments, they are devitalized and therefore susceptible to reinfections and fractures. The American Association of Endodontists (AAE) has made a tremendous effort to revitalize disinfected immature permanent teeth in children and adolescents with diagnoses including pulp necrosis or apical periodontitis...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28822568/effects-of-lipopolysaccharide-on-the-proliferation-and-osteogenic-differentiation-of-stem-cells-from-the-apical-papilla
#19
Veera Lertchirakarn, Panuroot Aguilar
INTRODUCTION: Stem cells from the apical papilla (SCAPs) were suggested as the stem cell source in regenerative endodontic procedures. However, bone and/or cementum-like structure were observed in root canals. Lipopolysaccharide (LPS) in infected root canals might alter SCAPs' osteogenic differentiation pattern. The objectives of this study were to investigate the effects of LPS on SCAPs' proliferation and osteogenic differentiation. METHODS: The mesenchymal stem cell characteristics of SCAPs were confirmed...
November 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28822564/regenerative-endodontic-treatment-or-mineral-trioxide-aggregate-apical-plug-in-teeth-with-necrotic-pulps-and-open-apices-a-systematic-review-and-meta-analysis
#20
REVIEW
Mahmoud Torabinejad, Ali Nosrat, Prashant Verma, Oyoyo Udochukwu
INTRODUCTION: A mineral trioxide aggregate (MTA) apical plug (MAP) and regenerative endodontic treatment (RET) have shown acceptable clinical outcomes. However, comparative studies are scarce. The aims of this study were to examine the level of evidence for both treatments, conduct a systematic review of the literature on MAP and RET, and run a meta-analysis on the survival and success rates of teeth treated with these procedures. METHODS: Electronic searches were performed in MEDLINE, Web of Science, and the Cochrane Library...
November 2017: Journal of Endodontics
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