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Regenerative endodontic

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https://www.readbyqxmd.com/read/28545523/l-mimosine-and-hypoxia-can-increase-angiogenin-production-in-dental-pulp-derived-cells
#1
Klara Janjić, Michael Edelmayer, Andreas Moritz, Hermann Agis
BACKGROUND: Angiogenin is a key molecule in the healing process which has been successfully applied in the field of regenerative medicine. The role of angiogenin in dental pulp regeneration is unclear. Here we aimed to reveal the impact of the hypoxia mimetic agent L-mimosine (L-MIM) and hypoxia on angiogenin in the dental pulp. METHODS: Human dental pulp-derived cells (DPC) were cultured in monolayer and spheroid cultures and treated with L-MIM or hypoxia. In addition, tooth slice organ cultures were applied to mimic the pulp-dentin complex...
May 25, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28528141/portland-cement-induces-human-periodontal-ligament-cells-to-differentiate-by-upregulating-mir-146a
#2
Min-Ching Wang, Li-Yin Yeh, Wen-Yu Shih, Wan-Chun Li, Kuo-Wei Chang, Shu-Chun Lin
BACKGROUND/PURPOSE: Bioaggregates such as Portland cement (PC) can be an economical alternative for mineral trioxide aggregate (MTA) with additional benefit of less discoloration. MTA has been known to induce differentiations of several dental cells. MicroRNAs are important regulators of biological processes, including differentiation, physiologic homeostasis, and disease progression. This study is to explore how PC enhances the differentiation of periodontal ligament (PDL) cells in microRNAs level...
May 18, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28527851/intentional-replantation-of-an-avulsed-immature-permanent-incisor-a-case-report
#3
Claudio Maniglia-Ferreira, Fabio de Almeida Gomes, Marcelo de Morais Vitoriano
This case report discusses the successful endodontic treatment of an open apex maxillary right permanent central incisor that had been avulsed and incorrectly replanted in a 7-year-old patient. The tooth was carefully re-extracted followed by cleaning of the alveolar socket and immediate replantation. However, pulp necrosis was diagnosed, and regenerative endodontic treatment was performed. The root canal system was disinfected by passive ultrasonic irrigation with 2.5% sodium hypochlorite. At the first visit, the tooth was repositioned and immobilized with an appropriate semirigid splint...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28511779/an-evidence-based-review-of-the-efficacy-of-treatment-approaches-for-immature-permanent-teeth-with-pulp-necrosis
#4
REVIEW
Bill Kahler, Giampiero Rossi-Fedele, Nadia Chugal, Louis M Lin
INTRODUCTION: Two fundamental assumptions for teeth treated with regenerative endodontic procedures (REPs) are (1) that the clinical outcome is comparable with the traditional techniques of calcium hydroxide apexification and mineral trioxide aggregate apical barrier techniques and (2) that REPs will result in further root maturation. METHODS: A systematic review of the electronic databases (Scopus, PubMed, and Web of Science) involved a search for studies that used quantitative assessments of root maturation...
May 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28511093/hypoxia-based-strategies-for-regenerative-dentistry-views-from-the-different-dental-fields
#5
REVIEW
Anna Sonja Müller, Klara Janjić, Bledar Lilaj, Michael Edelmayer, Hermann Agis
The understanding of the cell biological processes underlying development and regeneration of oral tissues leads to novel regenerative approaches. Over the past years, knowledge on key roles of the hypoxia-based response has become more profound. Based on these findings, novel regenerative approaches for dentistry are emerging, which target cellular oxygen sensors. These approaches include hypoxia pre-conditioning and pharmacologically simulated hypoxia. The increase in studies on hypoxia and hypoxia-based strategies in regenerative dentistry highlights the growing attention to hypoxia's role in regeneration and its underlying biology, as well as its application in a therapeutic setting...
April 26, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28508244/interventions-for-the-endodontic-management-of-non-vital-traumatised-immature-permanent-anterior-teeth-in-children-and-adolescents-a-systematic-review-of-the-evidence-and-guidelines-of-the-european-academy-of-paediatric-dentistry
#6
REVIEW
M Duggal, H Jinn Tong, M Al-Ansary, W Twati, P F Day, H Nazzal
AIM: This systematic review was undertaken in order to develop guidelines for the European Academy of Paediatric Dentistry for the management of non-vital permanent anterior teeth with incomplete root development. METHODS: Three techniques were considered; apexification by single or multiple applications of calcium hydroxide, use of Mineral Trioxide Aggregate (MTA) for the creation of an apical plug followed by obturation of the root canal, and finally a Regenerative Endodontic Technique (RET)...
May 15, 2017: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28457638/provider-perceptions-of-treatment-options-for%C3%A2-immature-permanent-teeth
#7
Alison St Paul, Ceib Phillips, Jessica Y Lee, Asma A Khan
INTRODUCTION: Current treatment options for immature permanent teeth with pulpal necrosis include both apexification and regenerative endodontics. The purpose of this study was to survey endodontists on the use of these 2 treatment options. METHODS: Surveys were created by using Qualtrics and Teleform software and distributed by using the Salant and Dillman method. Endodontists (n = 1615) in 4 geographically and demographically diverse states, North Carolina, New York, Texas, and California, were surveyed...
April 27, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28449761/high-survival-and-clinical-success-rates-but-also-high-discoloration-rates-in-immature-necrotic-teeth-treated-with-regenerative-endodontic-procedures
#8
Romina Brignardello-Petersen
No abstract text is available yet for this article.
May 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28439906/regenerative-endodontic-treatment-of-perforated-internal-root-resorption-a-case-report
#9
M E Kaval, P Güneri, M K Çalışkan
AIM: To present the regenerative endodontic treatment procedure of a perforated internal root resorption case and its' clinical and radiographic findings after two years. SUMMARY: A 14-year-old female patient was referred complaining of moderate pain associated with her maxillary left lateral incisor. After radiographic examination, a perforated internal resorption lesion in the middle third of tooth 22 was detected. Under local anaesthesia and rubber dam isolation, an access cavity was prepared and the root canal was shaped using K-files under copious irrigation with 1% NaOCl, 17% EDTA and distilled water...
April 25, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28416302/effect-of-bacterial-biofilm-on-the-osteogenic-differentiation-of-stem-cells-of-apical-papilla
#10
Lakshmi Vishwanat, Rose Duong, Koyo Takimoto, Linda Phillips, Claudia O Espitia, Anibal Diogenes, Shivani B Ruparel, David Kolodrubetz, Nikita B Ruparel
INTRODUCTION: Although clinical success in regenerative endodontics is substantially high, histological success is limited to finding bone/cementum-like tissue instead of dentin within the canal space. The aims of this study were to investigate (1) the effect of bacterial biofilm on osteogenic gene expression in stem cells of the apical papilla (SCAP) and (2) the effect of bacterial antigens on the functional differentiation of SCAP into a mineralizing phenotype. METHODS: Using an ex vivo organotypic root canal model and an American Association of Endontists-recommended regenerative endodontic procedures, we evaluated SCAP differentiation in the presence and absence of an Enterococcus faecalis biofilm...
April 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28415948/use-of-platelet-rich-plasma-for-regeneration-in-non-vital-immature-permanent-teeth-clinical-and-cone-beam-computed-tomography-evaluation
#11
Adel Alagl, Sumit Bedi, Khalid Hassan, Jehan AlHumaid
Objective This study was performed to assess the clinical and radiological outcomes of a revascularization procedure in immature teeth with apical periodontitis using platelet-rich plasma (PRP). The PRP protocol and conventional revascularization protocol, which used a blood clot as the scaffold, were compared. Methods Thirty non-vital immature permanent teeth were randomly categorized into two groups. After disinfecting the root canal space with triple antibiotic paste (1:1:1 ciprofloxacin, metronidazole, and cefaclor), a tissue scaffold was created using either PRP or a blood clot (control) and covered with white mineral trioxide aggregate...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28403365/crown-discoloration-promoted-by-materials-used-in-regenerative-endodontic-procedures-and-effect-of-dental-bleaching-spectrophotometric-analysis
#12
Luciane Geanini Pena Dos Santos, Wilson Tadeu Felippe, Beatriz Dulcineia Mendes de Souza, Andrea Cristina Konrath, Mabel Mariela Rodríguez Cordeiro, Mara Cristina Santos Felippe
Objectives: To assess tooth crown's color after intracanal treatment with triple antibiotic paste (TAP) or calcium hydroxide (CH); cervical sealing with glass ionomer cement (GIC) or mineral trioxide aggregate (MTA); and bleaching with carbamide peroxide. Material and Methods: After pulp removal and color spectrophotometer measurement, 50 bovine incisors were divided into 4 experimental groups and one control (untreated). Experiments were performed in phases (Ph)...
March 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28366235/zinc-bioglasses-regulate-mineralization-in-human-dental-pulp-stem-cells
#13
Mei Huang, Robert G Hill, Simon C F Rawlinson
OBJECTIVE: A promising strategy in regenerative endodontics is the combination of human dental pulp stem cells (hDPSCs) with an appropriate biomaterial substrate. The effects of zinc and zinc containing bioactive glasses (ZnBGs) on hDPSCs have been characterized in this study. METHODS: ZnBGs were designed and produced. Then the odontogenic differentiation and mineralization potential of hDPSCs upon ZnBGs treatment were investigated. RESULTS: Free Zn ions (0-5ppm) enhanced proliferation and alkaline phosphatase (ALP) activity of hDPSCs...
March 30, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28360862/iodixanol-as-a-contrast-agent-in-a-fibrin-hydrogel-for-endodontic-applications
#14
Gabriel Hertig, Matthias Zehnder, Anna Woloszyk, Thimios A Mitsiadis, Anja Ivica, Franz E Weber
The application of biomaterials used in regenerative endodontics should be traceable. In this study, we checked some basic effects of rendering a fibrin hydrogel radiopaque using an iodine-based contrast agent (iodixanol) approved for systemic application. Fibrin hydrogels were prepared from a fibrin sealant (Tisseel) using either an isotonic iodixanol solution (Visipaque 320, test) or Tris buffer (control) as a diluent. Gelation kinetics, radiopacity, and swelling of lyophilized hydrogels were tested using standard methods...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28342218/histological-assessment-of-regenerative-endodontic-treatment-in-animal-studies-with-different-scaffolds-a-systematic-review
#15
REVIEW
Milad Altaii, Lindsay Richards, Giampiero Rossi-Fedele
BACKGROUND/AIM: The concept of regenerative endodontic procedures remains controversial. The aim of this study was to evaluate the histology of the tissues formed in immature animal teeth with necrotic and infected pulps after attempted endodontic regeneration procedures using different scaffolds. DESIGN: A systematic electronic literature search was performed in PubMed, Web of Science, Scopus, EMBASE, DOSS, and Cochrane Library databases. The terms used were a combination of the following: "immature permanent necrotic tooth or teeth" or "open apex or apices" and "regeneration or revitalization or revascularization" and "histology...
March 24, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28320538/bioactive-molecule-delivery-systems-for-dentin-pulp-tissue-engineering
#16
REVIEW
Suja Shrestha, Anil Kishen
INTRODUCTION: Regenerative endodontic procedures use bioactive molecules (BMs), which are active signaling molecules that initiate and maintain cell responses and interactions. When applied in a bolus form, they may undergo rapid diffusion and denaturation resulting in failure to induce the desired effects on target cells. METHODS: The controlled release of BMs from a biomaterial carrier is expected to enhance and accelerate functional tissue engineering during regenerative endodontic procedures...
March 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28303584/long-term-results-of-periodontal-regenerative-therapy-a-retrospective-practice-based-cohort-study
#17
Frank Bröseler, Christina Tietmann, Ann-Katrin Hinz, Søren Jepsen
AIM: Evaluation of the long-term effectiveness of regenerative treatment of intra-bony defects in periodontal practice. MATERIAL AND METHODS: A total of 1,008 intra-bony defects in 176 patients were analysed after using collagen-added deproteinized bovine bone mineral (DBBMc) with or without collagen membrane (CM) or enamel matrix derivative (EMD). Defects were classified as one- and two-wall and as shallow (≤6 mm), moderate (>6 and <11 mm) and deep (≥11 mm)...
March 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28294199/management-of-an-immature-partially-necrotic-permanent-molar-by-pulp-revascularization-%C3%A2-two-year-follow-up
#18
Julian Schmoeckel, Mhd Said Mourad, Christian H Splieth, Ruth M Santamaria
Root canal treatment of immature teeth is considered a great challenge for both the dentist and the patient. The thinness of the root canals walls and the lack of an apical barrier leads to unpredictable treatment results. Revascularization is a novel promising treatment option in the field of regenerative endodontics for management of immature necrotic permanent teeth. This case presents a successful treatment of an 8-year-old patient with a partially necrotic, immature permanent mandibular right first molar pulp by revascularization...
March 14, 2017: Quintessence International
https://www.readbyqxmd.com/read/28216269/antibacterial-effects-of-antimicrobials-used-in-regenerative-endodontics-against-biofilm-bacteria-obtained-from-mature-and-immature-teeth-with-necrotic-pulps
#19
Jordon C Jacobs, Alex Troxel, Ygal Ehrlich, Kenneth Spolnik, Josef S Bringas, Richard L Gregory, Ghaeth H Yassen
INTRODUCTION: We investigated the direct and residual antibacterial effects of intracanal antimicrobials against bacterial biofilms obtained from infected mature and immature teeth with necrotic pulps. METHODS: Sterile dentin slabs (n = 100) were inoculated with bacterial biofilms obtained from root canals of an immature or a mature tooth with pulpal necrosis and incubated anaerobically for 3 weeks (n = 50 per biofilm). Dentin infected with each type of biofilm received 1 week of treatment with 1 or 5 mg/mL double antibiotic paste (DAP) in methylcellulose hydrogels, calcium hydroxide, or placebo paste or received no treatment (n = 10)...
April 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28215344/rac1-regulates-the-proliferation-adhesion-migration-and-differentiation-of-mdpc-23-cells
#20
Jing Ren, Guobin Liang, Li Gong, Bing Guo, Hongwei Jiang
INTRODUCTION: Stem cells are responsible for replacing damaged pulp tissue; therefore, promoting their survival and inducing their adhesion to dentin are vital. As a member of the Rho family of guanosine triphosphatases, Rac1 is an important regulator of osteoblast functions. However, little is known about its role in regenerative endodontic procedures. The current study examined the role of Rac1 in the proliferation, migration, and odontoblastic differentiation of MDPC-23 cells. METHODS: MDPC-23 cells were transfected with small interfering RNA to knock down Rac1 expression, and then their proliferation, migration, adhesion, and odontoblastic differentiation were examined in vitro...
April 2017: Journal of Endodontics
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