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PO kidney transplantation

R Shahbazov, M Talanian, J L Alejo, F Azari, A Agarwal, K L Brayman
Introduction: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome of progressive fibrotic change in response to prolonged, repetitive, and typically severe insult to the peritoneal mesothelium, often occurring in the setting of peritoneal dialysis (PD). Clear guidelines for successful management remain elusive. We describe the successful surgical management of EPS in a 28-year-old male s/p deceased donor kidney transplant for end-stage renal disease (ESRD) secondary to focal segmental glomerulosclerosis (FSGS)...
2018: Case Reports in Surgery
Marco Bonani, Ursina Meyer, Diana Frey, Nicole Graf, Heike A Bischoff-Ferrari, Rudolf P Wüthrich
BACKGROUND/AIMS: In a randomized controlled clinical trial in kidney transplant recipients (NCT01377467) we have recently shown that RANKL inhibition with denosumab significantly improved areal bone mineral density (aBMD) when given during the first year after transplantation. The effect of denosumab on skeletal microstructure and bone strength in kidney transplant recipients is not known. METHODS: The purpose of the present bone microarchitecture ancillary study was to investigate high-resolution peripheral quantitative computed tomography (HRpQCT) data from the distal tibia and distal radius in 24 study patients that had been randomized to receive either two injections of denosumab 60 mg at baseline and after 6 months (n=10) or no treatment (n=14)...
2016: Kidney & Blood Pressure Research
Chi Yuen Cheung, Stanley Hok King Lo, Ching Kit Chan, Fu Keung Li, Ignatius Kum Po Cheng, Ka Foon Chau
Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal gastrointestinal neoplasms. However, GISTs occurring in kidney transplant recipients, including their treatment and outcome, are rarely described in literature. We hereby report two kidney transplant recipients with GISTs. Our first patient was diagnosed with high-risk epithelioid gastric GIST 2 years after kidney transplant. He received everolimus after resection and remained disease-free for 2 years before liver metastasis was confirmed...
February 2017: Asia-Pacific Journal of Clinical Oncology
Chia-Shen Chien, Hao Lun Luo, Chou Shu Ling, Po-Hui Chiang, Yen-Ta Chen, Yuan Tso Cheng
PURPOSE: To determine upper urinary tract urothelial carcinoma (UT-UC) behavior in patients with end-stage renal disease (ESRD) after kidney transplantation (KT). METHODS: From 2005 to 2012, 117 ESRD patients with localized UT-UC underwent nephroureterectomy at our institution. We divide these patients into two groups according to having had KT or not. Kaplan-Meier survival plot and multivariate analysis were used to evaluate whether kidney transplantation interfered with the UT-UC outcome...
August 2016: International Urology and Nephrology
Szu-Chia Chen, Po-Lin Kuo
Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During development, it promotes nephrogenesis and is strongly expressed in the ureteric bud and its derivatives. An increase in the concentration of galectin-3 has been reported to be associated with fibrosis of the kidneys...
April 14, 2016: International Journal of Molecular Sciences
Po-Chang Lee, Yang-Jen Chiang, Shih-Tse Chen
There were 1997 deceased donor renal transplants reported to the Taiwan Organ Registry and Sharing Center between April 1, 2005, and December 31, 2014. The median age of transplant recipients was 45 years, with most patients between 35 and 64 years old. The number of male patients was comparable to that of female patients. There were more blood type O patients than any other blood type. The 1-, 3-, and 5-year patient survival rates were 96%, 93%, and 89%, respectively. Graft survival rates at 1, 3, and 5 years were 94%, 88%, and 82%, respectively...
2014: Clinical Transplants
Chia-Yang Hsu, Po-Hong Liu, Yun-Hsuan Lee, Cheng-Yuan Hsia, Yi-Hsiang Huang, Yi-You Chiou, Han-Chieh Lin, Teh-Ia Huo
Hepatocellular carcinoma (HCC) patients with performance status (PS) 1 or 2 are considered similar in the Barcelona Clinic Liver Cancer (BCLC) system. The rationales are not fully studied. A total of 693 and 335 HCC patients were classified as PS 1 and 2, respectively, in a prospectively followed up database. One-to-one matched pairs between HCC patients were generated by using the propensity score with matching model. Survival analysis was performed and the hazard ratio was calculated with the Cox proportional hazards model...
July 2015: Medicine (Baltimore)
Po-Yu Tseng, Wu-Chang Yang, Chih-Yu Yang, Der-Cherng Tarng
BACKGROUND/AIMS: Hyperparathyroidism (HPT) is a common complication of chronic kidney disease and contributes to hypertension and cardiovascular risks. Successful kidney transplantation corrects abnormal mineral metabolism, but persistent HPT is still observed in up to 25% of patients one year after transplantation despite renal function improvement. The purpose of this study was to examine the long-term effects of parathyroidectomy (PTX) on blood pressure (BP) and graft function in patients with persistent post-transplant HPT...
2015: Kidney & Blood Pressure Research
Marília D'Elboux Guimarães Brescia, Paulo Celso Bosco Massarollo, Ernesto Sasaki Imakuma, Sérgio Mies
BACKGROUND: This randomized prospective clinical trial compared the hepatic venous outflow drainage and renal function after conventional with venovenous bypass (n = 15) or piggyback (n = 17) liver transplantation. METHODS: Free hepatic vein pressure (FHVP) and central venous pressure (CVP) measurements were performed after graft reperfusion. Postoperative serum creatinine (Cr) was measured daily on the first week and on the 14th, 21st and 28th postoperative days (PO)...
2015: PloS One
Mohammad F Shaikh, Farah Karipineni, Afshin Parsikia, Po-Nan Chang, Kamran Khanmoradi, Stalin Campos, Radi Zaki, Jorge Ortiz
OBJECTIVES: Grafts from extended criteria donors, donors after cardiac death, and elderly donors have an increased risk of delayed graft function, lower graft survival, longer hospital stay, higher costs, and increased medical sequelae. A modifiable risk factor for delayed graft function may be the performance of dialysis on the same day as renal transplant. We reviewed our institutional experience to determine whether dialysis performed within 24 hours of engraftment increased the incidence or length of delayed graft function...
April 2015: Experimental and Clinical Transplantation
Chi-Hao Chang, Po-Chao Chan, Jian-Ri Li, Chun-Jung Chen, Jeng-Jer Shieh, Yun-Ching Fu, Hong-Chen Chen, Ming-Ju Wu
Urothelial carcinoma is the most common type of malignancy in long-term dialysis patients and kidney transplant recipients in Taiwan. mTORCs (mammalian target of rapamycin complexes) and EGF are important in urothelial carcinoma. To identify the regulation of mTORCs upon EGF stimulation is necessary. mTOR integrates signals from growth factors via mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). The mechanism of mTORC1 action has been widely studied; however, the regulation of mTORC2 has not been well studied...
January 30, 2015: Oncotarget
Mark Zak, Bianca M Liederer, Deepak Sampath, Po-Wai Yuen, Kenneth W Bair, Timm Baumeister, Alexandre J Buckmelter, Karl H Clodfelter, Eric Cheng, Lisa Crocker, Bang Fu, Bingsong Han, Guangkun Li, Yen-Ching Ho, Jian Lin, Xiongcai Liu, Justin Ly, Thomas O'Brien, Dominic J Reynolds, Nicholas Skelton, Chase C Smith, Suzanne Tay, Weiru Wang, Zhongguo Wang, Yang Xiao, Lei Zhang, Guiling Zhao, Xiaozhang Zheng, Peter S Dragovich
Herein we report the optimization efforts to ameliorate the potent CYP3A4 time-dependent inhibition (TDI) and low aqueous solubility exhibited by a previously identified lead compound from our NAMPT inhibitor program (1, GNE-617). Metabolite identification studies pinpointed the imidazopyridine moiety present in 1 as the likely source of the TDI signal, and replacement with other bicyclic systems was found to reduce or eliminate the TDI finding. A strategy of reducing the number of aromatic rings and/or lowering cLogD7...
February 1, 2015: Bioorganic & Medicinal Chemistry Letters
Chia-Chi Hsu, Shen-Shin Chang, Po-Chang Lee, Sheau-Chiou Chao
Organ transplant recipients under immunosuppressive therapy have a highly increased risk of acquiring unusual opportunistic infections. Diagnosis of the etiology of infection may be difficult in clinical manifestations, which need further histological and biological investigations. We recently treated a male renal transplant recipient with a cutaneous phaeohyphomycosis due to Alternaria species. The diagnosis was based on microscopy and culture of the skin lesions. Treatment with oral itraconazole for 5 weeks was ineffective, then clinical improvement was achieved by combination of amphotericin B wet-packing and systemic antifungal therapy with oral voriconazole...
January 2015: Asian Journal of Surgery
Teresa P K Tse, Allan N L Chan, Tony K T Chan, Y C Po
Post-transplantation primary central nervous system lymphoma is an uncommon and fatal post-transplant lymphoproliferative disorder. Such lymphomas have been described in only a few case series in the literature. The incidence of this condition is rising with improved survival after organ transplantation. A case of post-transplantation primary central nervous system lymphoma in a young Chinese woman with systemic lupus erythematosus is described here. She presented with right-sided weakness and memory loss after tooth extraction 2 weeks before admission...
December 2014: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
Kyle K Nishiyama, Yves Pauchard, Lucas E Nikkel, Sapna Iyer, Chiyuan Zhang, Donald J McMahon, David Cohen, Steven K Boyd, Elizabeth Shane, Thomas L Nickolas
Patients with chronic kidney disease (CKD) who undergo kidney transplantation experience bone loss and increased risk of fracture. However, the mechanisms of this bone loss are unclear. Our objective was to use image registration to define the cortex to assess changes in cortical porosity (Ct.Po) in patients undergoing first-time kidney transplantation. We obtained serial measurements of parathyroid hormone (PTH) and bone turnover markers and used high-resolution peripheral quantitative computed tomography (HR-pQCT) to scan the distal radius and tibia in 31 patients (21 men, 10 women; aged 51...
March 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Jyuhn-Huarng Juang, Chien-Hung Kuo, Ying-Hsiu Liu, Han-Ying Chang, Chiung-Tong Chen
Dipeptidyl peptidase (DPP)-4 inhibitors increase circulating levels of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide which may promote β-cell proliferation and survival. This study tested if DPP-4 inhibition with MK-0431 is beneficial for diabetic mice syngeneically transplanted with a marginal number of islets. We syngeneically transplanted 150 C57BL/6 mouse islets under the kidney capsule of each streptozotocin-diabetic mouse and then treated recipients with (n = 21) or without (n = 17) MK-0431 (30 mg/kg/day, po) for 6 weeks...
2014: International Journal of Endocrinology
Po-Chang Lee, Yi Lin Chen, Wei-Ming Wang, Wan Chi Tu, Hsuan Yu Chen
Human leukocyte antigen (HLA) antibodies reactive to donor antigens (DSA) and non-donor specific antigens (NDSA) were detected by enzyme-linked immunosorbent assay (ELISA) to determine their impact on long-term graft survival. Among 162 patients who had no pre-transplant HLA antibodies, 5-year graft survival was 87%. There was a significant difference compared with 72% for 18 patients who had pre-transplant HLA antibodies (p=0.031). There was a significant difference in graft survival between patients with pre-transplant NDSA and those without HLA antibodies (p=0...
2013: Clinical Transplants
Yuan-Tso Cheng, Stuart M Flechner, Po-Hui Chiang
BACKGROUND: To evaluate the effect and safety of laparoscopy-assisted renal autotransplantation treatment for primary ureteral cancer (PUC). METHODS: Medical records of patients undergoing hand-assisted retroperitoneoscopic nephroureterectomy–extracorporeal total ureterectomy–renal autotransplantation–pyelocystostomy (Lap AutoTx) were analyzed. Demographic, intraoperative, and postoperative data were assessed. RESULTS: Fifteen patients diagnosed with PUC underwent this novel approach...
October 2014: Annals of Surgical Oncology
Joel B Durinka, Po-Nan Chang, Jorge Ortiz
INTRODUCTION: Oral and poster presentations at major meetings serve to rapidly present and share study results with the scientific community. On the other hand, full-text publication of abstracts in peer-reviewed journals provides dissemination of knowledge. The purpose of this study was to evaluate the publication rate of abstracts presented at the 2009 American Transplant Congress (ATC), to assess the factors influencing publication and determine the impact factor of these journals...
September 2014: Journal of Surgical Education
Zhe-Zhong Lin, Jhi-Joung Wang, Chi-Rung Chung, Po-Chang Huang, Bo-An Su, Kuo-Chen Cheng, Chung-Ching Chio, Chih-Chiang Chien
Chronic kidney disease increases the risk for hip fractures. Hip fractures are associated with increased mortality, decreased quality of life, and higher economic burden. To determine whether dialysis modality is associated with a higher incidence of hip fractures in patients with end-stage renal disease (ESRD), we used the Taiwan National Health Insurance Research Database to examine the records of 51,473 patients who began dialysis between 1999 and 2005. The patients were followed until death, transplantation, dialysis cessation, or 31 December 2008...
July 2014: Bone
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