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breast cancer IV surgery

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https://www.readbyqxmd.com/read/29909259/survival-benefit-of-surgical-removal-of-primary-tumor-in-patients-with-stage-iv-breast-cancer
#1
Hye Jin Kim, Eunyoung Kang, Jee Hyun Kim, Se Hyun Kim, Yu Jung Kim, In Ah Kim, Keun-Yong Eom, Su Min Chae, Kyu Min Kang, Eun Kyu Kim, Sung-Won Kim
BACKGROUND: Several studies have suggested that primary tumor removal improved overall survival for patients with stage IV breast cancer. However, the survival benefit of local treatment remains controversial. The purpose of the present study was to determine whether surgical removal of the primary tumor provides survival benefits to patients with stage IV breast cancer. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 155 patients with an initial diagnosis of stage IV breast cancer at Seoul National University Bundang Hospital from 2003 to 2014...
May 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29777404/randomized-trial-comparing-resection-of-primary-tumor-with-no-surgery-in-stage-iv-breast-cancer-at-presentation-protocol-mf07-01
#2
Atilla Soran, Vahit Ozmen, Serdar Ozbas, Hasan Karanlik, Mahmut Muslumanoglu, Abdullah Igci, Zafer Canturk, Zafer Utkan, Cihangir Ozaslan, Turkkan Evrensel, Cihan Uras, Erol Aksaz, Aykut Soyder, Umit Ugurlu, Cavit Col, Neslihan Cabioglu, Betül Bozkurt, Ali Uzunkoy, Neset Koksal, Bahadir M Gulluoglu, Bulent Unal, Can Atalay, Emin Yıldırım, Ergun Erdem, Semra Salimoglu, Atakan Sezer, Ayhan Koyuncu, Gunay Gurleyik, Haluk Alagol, Nalan Ulufi, Uğur Berberoglu, Mustafa Dulger, Omer Cengiz, Efe Sezgin, Ronald Johnson
BACKGROUND: The MF07-01 trial is a multicenter, phase III, randomized, controlled study comparing locoregional treatment (LRT) followed by systemic therapy (ST) with ST alone for treatment-naïve stage IV breast cancer (BC) patients. METHODS: At initial diagnosis, patients were randomized 1:1 to either the LRT or ST group. All the patients were given ST either immediately after randomization or after surgical resection of the intact primary tumor. RESULTS: The trial enrolled 274 patients: 138 in the LRT group and 136 in the ST group...
May 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29757686/predictors-of-unemployment-after-breast-cancer-surgery-a-systematic-review-and-meta-analysis-of-observational-studies
#3
Li Wang, Brian Y Hong, Sean A Kennedy, Yaping Chang, Chris J Hong, Samantha Craigie, Henry Y Kwon, Beatriz Romerosa, Rachel J Couban, Susan Reid, James S Khan, Michael McGillion, Victoria Blinder, Jason W Busse
Purpose Breast cancer surgery is associated with unemployment. Identifying high-risk patients could help inform strategies to promote return to work. We systematically reviewed observational studies to explore factors associated with unemployment after breast cancer surgery. Methods We searched MEDLINE, EMBASE, CINAHL, and PsycINFO to identify studies that explored risk factors for unemployment after breast cancer surgery. When possible, we pooled estimates of association for all independent variables reported by more than one study...
May 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29752333/the-endocrinology-of-male-breast-cancer
#4
REVIEW
Ian S Fentiman
Male breast cancer (MBC) is a rare disease but, as a result of epidemiological collaborations, there is now greater clarity concerning endocrine risk factors. The significant rise in global age-standardised mean BMI in men is likely to lead to increases in incidence of maturity-onset diabetes and MBC. The metabolic changes accompanying obesity decrease androgens and sex hormone-binding globulin (SHBG), thereby increasing available oestrogens. The higher rates of MBC in North and Equatorial Africa are largely due to liver damage from endemic bilharziasis and hepatitis B causing elevated oestradiol (E2 ) levels from hepatic conversion of androgen...
June 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29704919/the-characteristics-management-and-outcomes-of-older-women-with-breast-cancer-in-new-zealand
#5
Tania Blackmore, Ross Lawrenson, Chunhuan Lao, Melissa Edwards, Marion Kuper-Hommel, Mark Elwood, Ian Campbell
The aim of this study was to understand the characteristics of older women with breast cancer and to describe the current patterns of treatment and outcomes. The study included data from the combined Auckland and Waikato breast cancer registers, which hold information for 12, 372 women diagnosed with stage I-IV breast cancer between June 2000 and May 2013. Of these women, 2671 (21.6%) were over 70 years of age. Patient characteristics, treatment type and survival were compared across four-year age groups (70-74, 75-79, 80-84, 85+) and hormone receptor status...
June 2018: Maturitas
https://www.readbyqxmd.com/read/29697452/impact-of-breast-surgery-in-primary-metastasized-breast-cancer-outcomes-of-the-prospective-randomized-phase-iii-abcsg-28-posytive-trial
#6
Florian Fitzal, Vesna Bjelic-Radisic, Michael Knauer, Günther Steger, Michael Hubalek, Marija Balic, Christian Singer, Rupert Bartsch, Peter Schrenk, Lidija Soelkner, Richard Greil, Michael Gnant
BACKGROUND: Conflicting evidence exists regarding the value of surgical resection of the primary in stage IV breast cancer patients. OBJECTIVE: The prospective randomized phase III ABCSG-28 POSYTIVE trial evaluated median survival comparing primary surgery followed by systemic therapy to primary systemic therapy in de novo stage IV breast cancer. METHODS: Between 2011 and 2015, 90 previously untreated stage IV breast cancer patients were randomly assigned to surgical resection of the primary tumor followed by systemic therapy (Arm A) or primary systemic therapy (Arm B) in Austria...
April 24, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29695577/clinical-significance-of-the-neutrophil-to-lymphocyte-ratio-in-endocrine-therapy-for-stage-iv-breast-cancer
#7
Nozomi Iimori, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Takaharu Hatano, Tsutomu Takashima, Shuhei Tomita, Hisashi Motomura, Kosei Hirakawa, Masaichi Ohira
BACKGROUND: Studies have found that patients with cancer exhibit abnormal leukocyte fractions, such as elevated neutrophil count and diminished lymphocyte count, and that the neutrophil-to-lymphocyte ratio (NLR) provides a surrogate marker for prognosis and response to treatment of patients after radical surgery for several different types of cancer. However, few reports have addressed the association between the NLR and response to endocrine therapy. In this study, we carried out a clinical investigation to confirm whether or not the NLR predicted the response to endocrine therapy of stage IV breast cancer...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29652946/-impact-of-the-chilean-explicit-guaranties-health-system-ges-on-breast-cancer-treatment
#8
César Del Castillo Sm, M Elena Cabrera C, Lea Derio P, Fancy Gaete V, Gabriel Cavada Ch
Background Breast cancer is the most common malignant tumor in women in the world. In 2005, it was incorporated to the Explicit Guaranties Health System (GES) in Chile. Aim To describe the demographic and clinical characteristics of breast cancer patients and to determine the effect of incorporating these women to GES. Material and Methods Medical records of 5,119 women with breast cancer aged 59 ± 14 years, attended at six public hospitals between 2000 and 2010 were reviewed. Median follow up was 87 months (range 1-182)...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29628978/basic-findings-regarding-breast-cancer-in-korea-in-2015-data-from-a-breast-cancer-registry
#9
REVIEW
Sang Yull Kang, Yoo Seok Kim, Zisun Kim, Hyun-Yul Kim, Se Kyung Lee, Kyu-Won Jung, Hyun Jo Youn
The Korean Breast Cancer Society (KBCS) has established a nationwide breast cancer database using an online registration program in 1996. The present study aimed to analyze the basic findings and trends of breast cancer in Korea in 2015 using the data provided by the Korea Central Cancer Registry and the KBCS. In 2015, a total of 22,550 patients were newly diagnosed with breast cancer, of which 3,331 were carcinoma in situ cases and 19,219 were invasive cancer cases. The incidence rate of breast cancer in Korea has steadily increased since the nationwide database was established, and the crude rate and age-standardized rate including that of carcinoma in situ , were 88...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29609018/curative-resection-of-advanced-esophageal-cancer-with-metachronous-stage-iv-breast-cancer-a-case-report
#10
Yusuke Gokon, Tadashi Sakurai, Fumiyoshi Fujishima, Yusuke Taniyama, Takahiro Heishi, Hiroshi Okamoto, Shota Maruyama, Hirotaka Ishida, Yu Onodera, Hironobu Sasano, Takashi Kamei
INTRODUCTION: Recent studies have shown the safety and efficacy of curative resection of esophageal cancer with multiple primary cancers. However, our literature search revealed no curative surgery cases for esophageal cancer in patients with multiple primary cancers with distant metastasis. CASE PRESENTATION: A 75-year-old woman visited our hospital with dysphagia. She had a history of breast cancer with multiple bone metastasis. Esophagogastroduodenoscopy revealed a circumferential mass in the upper intrathoracic esophagus...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29597131/health-related-quality-of-life-and-utility-scores-of-patients-with-breast-neoplasms-in-china-a-multicenter-cross-sectional-survey
#11
Le Wang, Ju-Fang Shi, Juan Zhu, Hui-Yao Huang, Ya-Na Bai, Guo-Xiang Liu, Xian-Zhen Liao, A-Yan Mao, Jian-Song Ren, Xiao-Jie Sun, Lan-Wei Guo, Yi Fang, Qi Zhou, Heng-Min Ma, Xiao-Jing Xing, Lin Zhu, Bing-Bing Song, Ling-Bin Du, Ling Mai, Yu-Qin Liu, Ying Ren, Li Lan, Jin-Yi Zhou, Xiao Qi, Xiao-Hua Sun, Pei-An Lou, Shou-Ling Wu, Ni Li, Kai Zhang, Jie He, Min Dai
BACKGROUND: Health-related quality of life and utility scores of patients with breast cancer and precancerous lesions are sparse in China. This study aimed to derive utility scores of patients with breast cancer and precancer in China. MATERIAL AND METHODS: An interviewer-administered cross-sectional survey was conducted in 12 provinces across China from 2013 to 2014. The three-level EuroQol-5-Dimension instrument was used to evaluate quality of life, and utility scores were generated using the Chinese value set...
June 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29545938/the-impact-of-surgical-excision-of-the-primary-tumor-in-stage-iv-breast-cancer-on-survival-a-meta-analysis
#12
Shuangshuang Lu, Jiayi Wu, Yan Fang, Wei Wang, Yu Zong, Xiaosong Chen, Ou Huang, Jian-Rong He, Weiguo Chen, Yafen Li, Kunwei Shen, Li Zhu
Introduction: Approximately 5% of primary breast cancer patients present de novo stage IV breast cancer, for whom systematic therapy is the mainstream treatment. The role of surgical excision of the primary tumor has been controversial due to inconsistent results of relevant studies. Recently, with the reports of some relevant preclinical data, retrospective studies and randomized clinical trials, we've got more evidence to reexamine the issue. Based on those above, a literature review and meta-analysis was performed to determine whether surgery of the primary tumor could improve overall survival in the setting of stage IV breast cancer...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29505670/clinical-and-economic-burden-associated-with-stage-iii-to-iv-triple-negative-breast-cancer-a-seer-medicare-historical-cohort-study-in-elderly-women-in-the-united-states
#13
Kendra L Schwartz, Michael S Simon, Lauren C Bylsma, Julie J Ruterbusch, Jennifer L Beebe-Dimmer, Neil M Schultz, Scott C Flanders, Arie Barlev, Jon P Fryzek, Ruben G W Quek
BACKGROUND: The current study was performed to describe patient characteristics, treatment patterns, survival, health care resource use (HRU), and costs among older women in the United States with advanced (American Joint Committee on Cancer stage III/IV) triple-negative breast cancer (TNBC) in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database. METHODS: Women who were aged ≥66 years at the time of diagnosis and diagnosed with advanced TNBC between January 1, 2007, and January 1, 2011, in the SEER-Medicare database and who were followed for survival through December 31, 2013, were eligible...
May 15, 2018: Cancer
https://www.readbyqxmd.com/read/29480890/is-total-femur-replacement-a-reliable-treatment-option-for-patients-with-metastatic-carcinoma-of-the-femur
#14
Florian Sevelda, Wenzel Waldstein, Joannis Panotopoulos, Alexandra Kaider, Philipp Theodor Funovics, Reinhard Windhager
BACKGROUND: The majority of metastatic bone lesions to the femoral bone can be treated without surgery or with minimally invasive intramedullary nailing. In rare patients with extensive metastatic disease to the femur, total femur replacement may be the only surgical alternative to amputation; however, little is known about this approach. QUESTIONS/PURPOSES: In a highly selected small group of patients with metastatic carcinoma of the femur, we asked: (1) What was the patient survivorship after this treatment? (2) What was the implant survivorship free from all-cause revision and amputation, and what complications were associated with this treatment? (3) What functional outcomes were achieved by patients after total femur replacement for this indication? METHODS: Eleven patients (three men, eight women) with a mean age of 64 years (range, 41-78 years) received total femur replacements between 1986 and 2016; none were lost to followup...
May 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29460033/factors-associated-with-improved-outcomes-for-metastatic-inflammatory-breast-cancer-patients
#15
Anna Weiss, Rhiana S Menen, Heather Y Lin, Yu Shen, Kelly J Rosso, Simona Shaitelman, Wendy Woodward, Vicente Valero, Naoto T Ueno, Isabelle Bedrosian, Gildy Babiera
PURPOSE: Controversy exists regarding the role of locoregional therapy for stage IV inflammatory breast cancer (IBC). This study aims to determine indicators of prognosis, including primary tumor resection, for stage IV IBC patients. METHODS: Using the National Cancer Data Base, female patients diagnosed 2010-2013 with unilateral a priori metastatic T4d invasive adenocarcinoma of the breast were identified. We conducted propensity score matched analysis to balance confounders of surgery versus no-surgery...
June 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29392582/intrathecal-trastuzumab-in-the-management-of-her2-breast-leptomeningeal-disease-a-single-institution-experience
#16
Nicholas B Figura, Wendy Long, Michael Yu, Timothy J Robinson, Sepideh Mokhtari, Arnold B Etame, Nam D Tran, Roberto Diaz, Hatem Soliman, Heather S Han, Solmaz Sahebjam, Peter A Forsyth, Kamran A Ahmed
PURPOSE: Leptomeningeal disease is a rare and devastating presentation of advanced stage metastatic breast cancer with historically poor overall survival. We assessed the safety and feasibility of intrathecal (IT) trastuzumab in HER2+ leptomeningeal disease. METHODS: A total of 13 patients were treated at our institution with IT trastuzumab beginning November 2012 and followed until November 2017. Outcomes including craniospinal progression as well as overall survival (OS) following initiation of IT trastuzumab were assessed from review of the clinical chart and radiologic examinations...
February 1, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29362351/-a-case-of-advanced-breast-cancer-with-liver-metastasis-successfully-treated-with-multi-disciplinary
#17
Masashi Sakagami, Tomohiro Hirano, Shuhei Suzuki, Keita Adachi, Hitomi Kubota, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai
We report a case of advanced breast cancer with liver metastasis(T2N1M1, Stage IV )achieving a significant improvement of QOL by multi-disciplinary therapy. The patient was 37-year-old woman who had breast lump and axillary lymph nodes swelling with liver metastasis. A core needle biopsy for breast tumor led to a diagnosis of an invasive ductal carcinoma, negative for estrogen receptor and progesterone receptor, and positive for HER2/neu protein expression. The Ki-67 positive cell index was 40%. She received 16 courses of DOC plus HER plus PER(docetaxel 75mg/m / 2, trastuzumab 6 mg/kg, pertu- zumab 450mg/body, and received 4 courses of EC(epirubicin 90mg/m / 2, cyclophosphamide 600 mg/m2)...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29362339/-a-case-of-stage-iv-metaplastic-breast-cancer-in-which-primary-tumor-was-removed-after-treatment-with-anti-her2-systemic-therapy
#18
Chiyomi Egawa, Junichi Inatome, Takuya Sakamoto, Atsushi Naito, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Yoshinori Kagawa, Atsushi Takeno, Yutaka Takeda, Kohei Murata, Yuichi Takatsuka, Takayoshi Goto, Teruaki Nagano
The patient was a 58-year-oldpostmenopausal woman. Vacuum assistedbiopsy of the left breast tumor revealedinvasive ductal carcinoma. Immunohistochemical examination was negative for estrogen receptor(ER), negative for progesterone receptor(PgR), andshowedan HER2 score of 3+. FDG-PET/CT revealedmultiple metastases to the left supracravicular and axillary lymph nodes and lungs. She was diagnosed with HER2-positive T3N3M1, Stage IV breast cancer. A 2-year regimen of chemotherapy with trastuzumab andvinorelbine achieveda complete response with regardto the metastatic sites; however, the size of the primary tumor increasedd espite the chemotherapy, andsurgical resection of the left breast with axillary lymph node dissection was performed for local control...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29361312/the-usefulness-of-interpectoral-block-as-an-analgesic-technique-in-breast-cancer-surgery
#19
R Ortiz de la Tabla González, P Gómez Reja, D Moreno Rey, C Pérez Naranjo, I Sánchez Martín, M Echevarría Moreno
OBJECTIVE: To compare the analgesic efficacy of continuous interpectoral block (CIPB) compared to intravenous analgesia (IV) after breast surgery. MATERIAL AND METHOD: A prospective, comparative and randomised study of women aged from 18-75years, ASAI-III, operated for breast cancer. In group1 (CIPB) after general anaesthetic, an ultrasound-guided interpectoral catheter was placed and 30mL of 0.5% ropivacaine was administered through it. In the event of an increase in heart rate and blood pressure >15% after the surgical incision, intravenous fentanyl 1μg·kg-1 was administered, repeating the dose as necessary...
April 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29361118/assessment-of-circulating-tumor-cells-as-a-predictive-biomarker-of-histology-in-women-with-suspected-ovarian-cancer
#20
Emil Lou, Rachel I Vogel, Deanna Teoh, Spencer Hoostal, Aaron Grad, Matthew Gerber, Minnu Monu, Tomasz Lukaszewski, Jaai Deshpande, Michael A Linden, Melissa A Geller
Background: The clinical assessment of circulating tumor cells (CTCs) as a blood-based biomarker is FDA-approved for use in breast, colorectal, and prostate cancers. The objective of this prospective clinical study was to determine whether pretreatment CTCs are a useful diagnostic biomarker in women with complex pelvic masses. Methods: Whole blood was collected from 49 women with newly diagnosed pelvic masses. The presence of CTCs was compared between women with and without ovarian cancer histopathologic diagnosis after surgery using a Chi-squared test...
March 21, 2018: Laboratory Medicine
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