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breast cancer IV surgery

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https://www.readbyqxmd.com/read/28334844/significance-of-primary-lesion-resection-in-stage-iv-breast-cancer
#1
Tadahiko Shien, Hiroji Iwata
Systemic treatment with drugs is administered to prolong survival and palliate symptoms in Stage IV breast cancer patients who have distant metastases at diagnosis. Surgical procedures for the primary tumor are not actively recommended in guidelines due to lack of evidence indicating prognostic benefit. Recently, several retrospective studies have shown primary tumor resection to prolong overall survival in patients with Stage IV breast cancer. Prospective randomized trials began enrolling patients to examine this possibility and two have already reported results...
February 23, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28331756/the-management-and-outcomes-of-male-breast-cancer
#2
Ömer Uslukaya, Metehan Gümüş, Hatice Gümüş, Zübeyir Bozdağ, Ahmet Türkoğlu
OBJECTIVE: Due to a lack of sufficient data, the treatment protocols for male breast cancer are usually the same as those used for female breast cancer. The aim of the current study was to present our clinical experience with male breast cancer. MATERIALS AND METHODS: The records of 37 patients who were treated for male breast cancer in our hospital between 2004 and 2014 were reviewed retrospectively. The data of patients were recorded and analyzed. RESULTS: The mean age of the patients was 63...
October 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28314588/risk-of-breast-cancer-after-a-diagnosis-of-ovarian-cancer-in-brca-mutation-carriers-is-preventive-mastectomy-warranted
#3
Jacob McGee, Vasily Giannakeas, Beth Karlan, Jan Lubinski, Jacek Gronwald, Barry Rosen, John McLaughlin, Harvey Risch, Ping Sun, William D Foulkes, Susan L Neuhausen, Joanne Kotsopoulos, Steven A Narod
OBJECTIVE: Preventive breast surgery and MRI screening are offered to unaffected BRCA mutation carriers. The clinical benefit of these two modalities has not been evaluated among mutation carriers with a history of ovarian cancer. Thus, we sought to determine whether or not BRCA mutation carriers with ovarian cancer would benefit from preventive mastectomy or from MRI screening. METHODS: First, the annual mortality rate for ovarian cancer patients was estimated for a cohort of 178 BRCA mutation carriers from Ontario, Canada...
March 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28292995/-a-case-of-stage-iv-breast-cancer-with-long-term-survival-by-chemotherapy-developing-pulmonary-tumor-thrombotic-microangiopathy-during-the-treatment-course
#4
Kana Kobayashi, Akari Murakami, Saaya Komatsu, Kanako Nishiyama, Michiko Yamashita, Wakana Sugimori, Yoshiaki Kamei, Hiroaki Asai, Akiyoshi Ogimoto, Kazuo Honda, Yasutsugu Takada
Pulmonary tumor thrombotic microangiopathy(PTTM)caused by pulmonary artery microscopic tumor emboli and fibrocellular and/or fibromuscular proliferation leads to progressive pulmonary hypertension and respiratory failure.The prognosis is extremely poor and most patients die shortly after onset.We report a patient with Stage IV breast cancer and long-term survival who developed PTTM during chemotherapy treatment.A 63-year-old woman with multiple metastases in her cerebellum, bone, lung, and lymph node after left breast conserving surgery started to experience dyspnea and malaise 7 years after the surgery...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28243172/uncemented-arthroplasty-after-hip-metastatic-disease-and-multiple-myeloma
#5
André Mathias Baptista, Sergio Pinheiro de Souza Meirelles, Daniel César Seguel Rebolledo, Luiz Filipe Marques Correia, Olavo Pires de Camargo
OBJECTIVE: To describe a case series using a combination of narrative, graphical exploratory analysis and Bayesian Network modeling. METHODS: Case series with 34 patients undergoing uncemented and hybrid arthroplasty procedures secondary to hip pain or fracture secondary to metastatic disease or multiple myeloma. RESULTS: The most common tumors included gastrointestinal, multiple myeloma and breast cancer. Most devices were total arthroplasty (n = 16, 84...
July 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28228708/local-resection-of-primary-tumor-in-upfront-stage-iv-breast-cancer
#6
Thomas Kolben, Theresa M Kolben, Isabelle Himsl, Tom Degenhardt, Jutta Engel, Rachel Wuerstlein, Sven Mahner, Nadia Harbeck, Steffen Kahlert
BACKGROUND: This study aimed to identify the association of local surgery of the primary tumor in metastatic breast cancer (MBC) patients with overall survival (OS) and prognostic factors. PATIENTS AND METHODS: Patients with primary MBC (1990-2006) were included in our retrospective analysis (n = 236). 83.1% had surgery for the primary tumor. OS was evaluated using Kaplan-Meier estimates. Predictive factors for OS were determined. RESULTS: Median follow-up was 123 months for all patients still alive at the time of analysis...
December 2016: Breast Care
https://www.readbyqxmd.com/read/28169842/challenges-in-management-of-squamous-cell-carcinoma-of-the-anus-in-new-england-and-across-the-united-states-a-review-of-the-national-cancer-data-base
#7
Victor E Pricolo, Kyle L Viani, Matteo Bonvini, Carlo F Abelli, Tracey J McDuffie
BACKGROUND: Management of squamous cell carcinoma of the anus (SCCA) is becoming more relevant, as its incidence continues to increase. The purpose of this study was to evaluate regional and national data to assess trends in epidemiology, access to cancer center care, and overall management strategies in SCCA. STUDY DESIGN: A review of available data from the American College of Surgeons Committee on Cancer National Cancer Data Base focused on incidence, sex, age, stage at diagnosis, distance traveled for care, and utilization of therapy as first course of treatment (FCT)...
February 6, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28133011/-evaluation-of-bevacizumab-in-combination-with-weekly-paclitaxel-for-locally-advanced-breast-cancer
#8
Hitoshi Sugimoto, Fukuichiro Orita, Yuichiro Kume, Hironobu Baba, Yuya Sato, Naoaki Hoshino, Yoshinobu Nishioka
Locally advanced breast cancer that exhibits bleeding, has a foul odor, and expresses an exudate often reduces the quality of life(QOL). Bevacizumab(Bv)in combination with weekly paclitaxel(PTX)therapy has a high response rate. To date, we have used this combination for 8 cases of locally advanced breast cancer in our hospital. The patients' mean age was 62.1 years. The tumors were T4b in 6 cases, T4c in 1 case and T4d in 1 case. The clinical stage was Stage III B in 1 case and Stage IV in 7 cases. The subtype was Luminal A in 2 cases, Luminal B in 4 cases, and triple negative in 2 cases...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28112378/combination-twist1-and-ca15-3-in-axillary-lymph-nodes-for-breast-cancer-prognosis
#9
Xiaowei Jiang, Dan Guo, Wenfang Li, Tianwu Yu, Jian Zhou, Jianping Gong
Twist1 overexpression is involved in epithelial‑mesenchymal transition resulting in migration and metastasis of breast cancer. Carcinoma antigen 15‑3 (CA15‑3) is widely used to monitor the prognosis for patients after treatment. However, the significance of Twist1 in axillary lymph nodes (ALN) and CA15‑3 for co‑examination for survival rates remains to be elucidated. The present study aimed to explore the role of the combination of Twist1 expression in metastasized ALN and the serum level of CA15‑3 in evaluating the prognosis of patients with breast cancer...
January 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28062979/contemporary-indications-for-diagnostic-open-biopsy-in-women-assessed-for-screen-detected-breast-lesions-a-ten-year-single-institution-series-of-814-consecutive-cases
#10
Gelareh Farshid, P Grantley Gill
PURPOSE: In contemporary practice, 5% of women with non-malignant needle biopsies of screen-detected lesions still require diagnostic open biopsy (OBx). Our aims are to (i) capture a snapshot of the contemporary indications for OBx in screen-detected lesions; (ii) determine upgrade rates to malignancy (DCIS or invasive cancer); (iii) identify indications with sufficiently low upgrades to justify avoidance of OBx and (iv) propose plausible non-surgical alternatives. METHODS: Between Jan 2005 and Dec 2014, women assessed for a screen-detected lesion and recommended for OBx are included...
January 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28057845/targeting-the-epithelial-to-mesenchymal-transition-the-case-for-differentiation-based-therapy
#11
Diwakar R Pattabiraman, Robert A Weinberg
Although important strides have been made in targeted therapy for certain leukemias and subtypes of breast cancer, the standard of care for most carcinomas still involves chemotherapy, radiotherapy, surgery, or a combination of these. Two processes serve as obstacles to the successful treatment of carcinomas. First, a majority of deaths from these types of cancers occurs as a result of distant metastases and not the primary tumors themselves. Second, subsets of cells that are able to survive conventional therapy drive the aggressive relapse of the tumors, often in forms that are resistant to treatment...
January 5, 2017: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/28048140/mo-fg-campus-jep2-05-mri-guided-single-fraction-boost-delivery-on-individual-axillary-lymph-nodes
#12
T C F van Heijst, N Hoekstra, M E P Philippens, D Eschbach, J J W Lagendijk, H J G D van den Bongard, B van Asselen
PURPOSE: The Utrecht MRI-linac (MRL) design enables new MR-guided radiotherapy (RT) approaches. This is a feasibility study for a single-fraction high dose (boost) to individual lymph nodes (LNs) in breast-cancer patients, after breast-conserving surgery (BCS) and hypofractionated whole-breast irradiation (WBI) with conventional axillary RT (AxRT). METHODS: After written informed consent, 5 breast-cancer patients (cT1-3N0) were enrolled (NL500460.041.14 trial) and underwent 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043695/standardizing-the-complication-rate-after-breast-reduction-using-the-clavien-dindo-classification
#13
Raimund Winter, Isabella Haug, Patricia Lebo, Martin Grohmann, Frederike M J Reischies, Janos Cambiaso-Daniel, Alexandru Tuca, Theresa Rienmüller, Herwig Friedl, Stephan Spendel, Abigail A Forbes, Paul Wurzer, Lars-P Kamolz
BACKGROUND: Published complication rates for breast reduction surgery, also known as reduction mammaplasty, vary between 4% and 54%. This wide range of complication rates could be attributable to the lack of a standardized classification of complications in plastic surgery. The aim of this study was to analyze our single-center complication rates after reduction mammaplasty using the Clavien-Dindo classification. METHODS: We performed a retrospective chart review studying 804 patients between the ages of 18 and 81 years old who underwent breast reduction between 2005 and 2015 at our institution...
December 30, 2016: Surgery
https://www.readbyqxmd.com/read/27998656/impact-of-primary-tumor-surgery-in-stage-iv-male-breast-cancer
#14
Mahvish Muzaffar, Swapnil Kachare, Nasreen Vohra
BACKGROUND: Primary tumor surgery (PTS) is not a standard treatment modality in stage IV breast cancer. Retrospective studies in female breast cancer show improved survival in women undergoing PTS; however, data regarding the impact of surgery in male breast cancer are lacking. The objective of this study was to analyze the impact of PTS on survival among men with metastatic breast cancer. METHODS: A retrospective study was conducted of men diagnosed with metastatic breast cancer at diagnosis were identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1988 to 2011...
November 22, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27988977/prognostic-factors-for-metachronous-contralateral-breast-cancer-implications-for-management-of-the-contralateral-breast
#15
Schelomo Marmor, Pamela R Portschy, Erin E Burke, Beth A Virnig, Todd M Tuttle
The absolute number of breast cancer survivors who are at risk for metachronous contralateral breast cancer (mCBC) has dramatically increased. The objectives of this study were to identify factors predictive of survival for patients with mCBC and to determine clinicopathological factors predictive of advanced mCBC. Using the Surveillance, Epidemiology, and End Results data base, we identified women, ages 18-80, diagnosed with invasive breast cancer from 1992 to 2010. We excluded patients with bilateral and stage IV primary breast cancer...
December 18, 2016: Breast Journal
https://www.readbyqxmd.com/read/27920624/neoadjuvant-chemotherapy-with-docetaxel-carboplatin-and-weekly-trastuzumab-is-active-in-her2-positive-early-breast-cancer-results-after-a-median-follow-up-of-over-4-years
#16
Hans-Christian Kolberg, Leyla Akpolat-Basci, Miltiades Stephanou, Bahriye Aktas, Carla Verena Hannig, Cornelia Liedtke
INTRODUCTION: Most patients with HER2-positive breast cancer receive chemotherapy and trastuzumab. Data from adjuvant trials have shown that the combination of docetaxel, carboplatin and weekly trastuzumab (TCH) is well tolerated and as effective as anthracycline-containing regimes. Previous investigations on neoadjuvant treatment with taxanes, platinum salts and trastuzumab showed pathological complete remission (pCR) rates between 43.3 and 76%. To date, the longest published follow-up in this indication is 3 years...
October 2016: Breast Care
https://www.readbyqxmd.com/read/27829423/relationship-between-traditional-chinese-medicine-constitutional-types-with-chemotherapy-induced-nausea-and-vomiting-in-patients-with-breast-cancer-an-observational-study
#17
Yi Liu, Ting Pan, Wenjing Zou, Ye Sun, Yun Cai, Rui Wang, Pingping Han, Zhe Zhang, Qunying He, Feng Ye
BACKGROUND: The theory of traditional Chinese medicine (TCM) constitution involves genetic characteristics, psychological factors, organ functions, and many other aspects. Studies have shown that TCM constitution is associated with HLA polymorphisms and has a genetic basis. A large number of Chinese studies have suggested that the clinical evolution of breast cancer may differ among patients with different TCM constitutions. In addition, patients with breast cancer and different TCM constitutions may have different degrees of myelosuppression after chemotherapy...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27812853/therapeutic-role-of-axillary-lymph-node-dissection-in-patients-with-stage-iv-breast-cancer-a-population-based-analysis
#18
San-Gang Wu, Feng-Yan Li, Yue Chen, Jia-Yuan Sun, Huan-Xin Lin, Qin Lin, Zhen-Yu He
PURPOSE: To assess the clinical value of axillary lymph node (ALN) dissection in stage IV breast cancer. METHODS: Patients with a diagnosis of stage IV breast cancer from 1990 to 2010 were identified using the Surveillance, Epidemiology, and End Results database. Univariate and multivariate Cox regression analyses were performed to analyze the effect of ALN dissection and ALN status on breast cancer-specific survival (BCSS) and overall survival (OS). RESULTS: A total of 11,645 patients were identified...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27760935/-a-multivariate-analysis-of-the-efficacy-of-adjuvant-chemotherapy-in-triple-negative-breast-cancer
#19
Yoshinori Nio, Shiro Imai, Kayo Uesugi, Mikako Tamaoki, Masashi Tamaoki, Riruke Maruyama
Triple-negative breast cancers(TNBCs)are associated with early recurrence after surgery and unfavorable prognoses. To date, no effective therapies for TNBCs have been established. The present study was designed to evaluate the efficacy of adjuvant chemotherapy(ACT)for 111 TNBCs using a retrospective multivariate analysis(MVA). The intravenous(iv)ACTs included docetaxel, epirubicin, gemcitabine, and vinorelbine. The oral ACTs included UFT, doxifluridine, and cyclophosphamide. The 10-year disease-free survival(DFS)and overall survival(OS)rates were 77...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27694551/impact-of-marital-status-on-tumor-stage-at-diagnosis-and-on-survival-in-male-breast-cancer
#20
Orimisan Samuel Adekolujo, Shourya Tadisina, Ujwala Koduru, Jill Gernand, Susan Jane Smith, Radhika Ramani Kakarala
The effect of marital status (MS) on survival varies according to cancer type and gender. There has been no report on the impact of MS on survival in male breast cancer (MBC). This study aims to determine the influence of MS on tumor stage at diagnosis and survival in MBC. Men with MBC ≥18 years of age in the SEER database from 1990 to 2011 were included in the study. MS was classified as married and unmarried (including single, divorced, separated, widowed). Kaplan-Meier method was used to estimate the 5-year cancer-specific survival...
September 29, 2016: American Journal of Men's Health
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