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microvascular complications of diabet

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https://www.readbyqxmd.com/read/28211604/delays-in-treatment-intensification-with-oral-antidiabetic-drugs-and-risk-of-microvascular-and-macrovascular-events-in-patients-with-poor-glycemic-control-an-individual-patient-simulation-study
#1
Henry J Folse, Jayanti Mukherjee, John J Sheehan, Alexandra J Ward, Ryan L Pelkey, Tuan A Dinh, Lei Qin, Jennifer Kim
AIMS: Despite guideline recommendations, many patients with type 2 diabetes on oral antidiabetic drugs (OADs) whose HbA1c results remain above target do not experience timely treatment intensification. This study uses the Archimedes Model® to estimate the consequences of delays in OAD treatment intensification on glycemic control and long-term outcomes at 5 and 20 years. MATERIALS AND METHODS: Using real world data, we modeled a cohort of hypothetical patients with HbA1c ≥8%, on metformin, with no history of insulin use...
February 17, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28210739/retinal-oxidative-stress-at-the-onset-of-diabetes-determined-by-synchrotron-ftir-widefield-imaging-towards-diabetes-pathogenesis
#2
Ebrahim Aboualizadeh, Mahsa Ranji, Christine M Sorenson, Reyhaneh Sepehr, Nader Sheibani, Carol J Hirschmugl
Diabetic retinopathy is a microvascular complication of diabetes that can lead to blindness. In the present study, we aimed to determine the nature of diabetes-induced, highly localized biochemical changes in the neuroretina at the onset of diabetes. High-resolution synchrotron Fourier transform infrared (s-FTIR) wide field microscopy coupled with multivariate analysis (PCA-LDA) was employed to identify biomarkers of diabetic retinopathy with spatial resolution at the cellular level. We compared the retinal tissue prepared from 6-week-old Ins2(Akita/+) heterozygous (Akita/+, N = 6; a model of diabetes) male mice with the wild-type (control, N = 6) mice...
February 17, 2017: Analyst
https://www.readbyqxmd.com/read/28190580/type-2-diabetes
#3
REVIEW
Sudesna Chatterjee, Kamlesh Khunti, Melanie J Davies
415 million people live with diabetes worldwide, and an estimated 193 million people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients with diabetes and leads to microvascular and macrovascular complications that cause profound psychological and physical distress to both patients and carers and put a huge burden on health-care systems. Despite increasing knowledge regarding risk factors for type 2 diabetes and evidence for successful prevention programmes, the incidence and prevalence of the disease continues to rise globally...
February 9, 2017: Lancet
https://www.readbyqxmd.com/read/28181108/circulating-levels-of-fibroblast-growth-factor-21-in-early-stage-diabetic-kidney-disease
#4
A Esteghamati, A Khandan, A Momeni, A Behdadnia, A Ghajar, M S Nikdad, S Noshad, M Nakhjavani, M Afarideh
AIMS/PURPOSE: Fibroblast growth factor 21 (FGF21), a hepatoadipokine with pleiotropic metabolic regulatory actions, is emerging as a novel biomarker of progressive nephropathy. We sought to evaluate circulating FGF21 and its association with clinical and biochemical characteristics as well as the urinary albumin excretion (UAE) rates in a population of patients with type 2 diabetes (T2D) with or without microalbuminuria and their matched healthy controls. METHODS: Cross-sectionally, 130 consecutive individuals comprising patients with T2D with (n = 44) or without (n = 44) microalbuminuria and their healthy controls (n = 42) were recruited for analysis...
February 8, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28159476/treatment-induced-neuropathy-of-diabetes-long-term-implications-in-type-1-diabetes
#5
Christopher H Gibbons
AIMS/HYPOTHESIS: Aggressive glucose control can result in treatment induced neuropathy of diabetes (TIND) if glycemic control is achieved too quickly. The aim of the present study is to describe the 8-year follow-up data on a cohort of individuals with type 1 diabetes who developed TIND. METHODS: Twenty-six individuals with type 1 diabetes and TIND were followed longitudinally for 8years with regular quantitative measurement of pain, neurological examinations and evaluation of microvascular complications...
January 21, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28158221/association-of-prediabetes-associated-single-nucleotide-polymorphisms-with-microalbuminuria
#6
Jong Wook Choi, Shinje Moon, Eun Jung Jang, Chang Hwa Lee, Joon-Sung Park
Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is crucial in the pathogenesis of diabetic microvascular complications represented by microalbuminuria. Nonetheless, there is limited evidence regarding which single nucleotide polymorphisms (SNPs) are associated with prediabetes and whether genetic predisposition to prediabetes is related to microalbuminuria, especially in the general population. Our objective was to answer these questions. We conducted a genomewide association study (GWAS) separately on two population-based cohorts, Ansung and Ansan, in the Korean Genome and Epidemiology Study (KoGES)...
2017: PloS One
https://www.readbyqxmd.com/read/28139436/predictors-of-cardiovascular-risk-among-patients-with-type-1-diabetes-a-critical-analysis-of-the-metabolic-syndrome-and-its-components
#7
V Gingras, C Leroux, A Fortin, L Legault, R Rabasa-Lhoret
Patients with type 1 diabetes (T1D) are at increased risk for cardiovascular diseases. The metabolic syndrome (MetS), a complex disorder defined by a cluster of interconnected factors including abdominal obesity, hypertension, dyslipidaemia and insulin resistance, has been proposed to identify patients with T1D at high cardiovascular risk. The MetS has been identified in 8-45% of patients with T1D, depending on the definition and cohort studied. However, clinicians and researchers face several issues with the criteria for MetS in patients with T1D, therefore questioning its value in routine care...
January 27, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28138697/niaspan-inhibits-diabetic-retinopathy%C3%A2-induced-vascular-inflammation-by-downregulating-the-tumor-necrosis-factor%C3%A2-%C3%AE-pathway
#8
Yang Wang, Xiangda Meng, Hua Yan
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes and a major cause of blindness in the developing world. Early DR is characterized by vascular neuroinflammation, cell apoptosis and breakdown of the blood‑retinal barrier (BRB). However, optimal treatment options and associated mechanisms remain unclear. Niaspan, which is widely used in the prevention and treatment of hyperlipidemia‑associated diseases, has been reported to inhibit inflammation. However, the effects of Niaspan and the mechanisms underlying the anti‑inflammatory effects of Niaspan on DR have yet to be reported...
January 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28129474/role-of-moesin-src-and-ros-in-advanced-glycation-end-product-induced-vascular-endothelial-dysfunction
#9
Wei-Jin Zhang, Pei-Xin Li, Xiao-Hua Guo, Qiao-Bing Huang
The disruption of endothelial integrity and the occurrence of angiogenesis in response to advanced glycation end products (AGEs) contribute greatly to micro- and macrovascular complications associated with diabetes mellitus (DM). Among human dermal, brain and retinal vascular endothelial cells, activation of ERM protein (Ezrin, radixin and moesin protein), moesin, by phosphorylation of Threonine 558 (Thr-558) is involved in AGE-induced hyperpermeability and angiogenesis via the Rho and Rho-associated protein kinase (Rho/ROCK) and p38 pathways...
January 27, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28129466/the-number-of-microvascular-complications-is-associated-with-an-increased-risk-for-severity-of-periodontitis-in-type-2-diabetic-patients-results-of-a-multicenter-hospital-based-cross-sectional-study
#10
Hiroshi Nitta, Sayaka Katagiri, Toshiyuki Nagasawa, Yuichi Izumi, Isao Ishikawa, Hajime Izumiyama, Isao Uchimura, Masao Kanazawa, Hiroshige Chiba, Akira Matsuo, Kazunori Utsunomiya, Haruyasu Tanabe, Izumi Takei, Soichiro Asanami, Hiroshi Kajio, Toaki Ono, Yoichi Hayashi, Kiichi Ueki, Masatomi Tsuji, Yoichi Kurachi, Toshikazu Yamanouchi, Yoshimi Ichinokawa, Toshiki Inokuchi, Akiko Fukui, Shigeru Miyazaki, Takashi Miyauchi, Reiko Kawahara, Hideki Ogiuchi, Narihito Yoshioka, Jun Negishi, Masatomo Mori, Kenji Mogi, Yasushi Saito, Hideki Tanzawa, Tetsuo Nishikawa, Norihiko Takada, Kishio Nanjo, Nobuo Morita, Naoto Nakamura, Narisato Kanamura, Hirofumi Makino, Fusanori Nishimura, Kunihisa Kobayashi, Yoshinori Higuchi, Toshiie Sakata, Shigetaka Yanagisawa, Chuwa Tei, Yuichi Ando, Nobuhiro Hanada, Shuji Inoue
AIMS/INTRODUCTION: To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetic patients. MATERIALS AND METHODS: This multi-center hospital-based cross-sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control...
January 27, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28127984/pregnancy-and-neonatal-outcomes-in-women-with-type-1-diabetes-mellitus
#11
L Durackova, A Kristufkova, M Korbel
AIM: The aim of study was to compare some perinatal outcomes in mothers with type 1 diabetes mellitus (T1DM). MATERIAL AND METHODS: All patients with T1DM delivered at the 1st Department of Obstetrics and Gynaecology of Faculty of Medicine, Comenius University in Bratislava from January 1st 2009 to December 31th 2015 were included to the study. RESULTS: Out of 118 diabetic mothers, 46.6 % had vasculopathy and 53. 4 % were without microvascular complications...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28127054/association-of-alcohol-intake-with-risk-of-diabetic-retinopathy-a-meta-analysis-of-observational-studies
#12
Wei Zhu, Yi-Fang Meng, Yan Wu, Ming Xu, Jiong Lu
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). The associations of alcohol intake with DR risk have demonstrated contradictory results. Relevant studies were identified by searching electronic databases (Medline, EMBASE and Web of Science) until May 2016. We identified a total of 12,875 DR cases among 37,285 participants in 15 observational studies. The pooled estimation of all the included observational studies was 0.91 (95% CI, 0.79 to 1.06) in a random-effect model...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28124440/chinese-herbal-drugs-for-the-treatment-of-diabetic-retinopathy
#13
REVIEW
Tapan Behl, Anita Kotwani
OBJECTIVES: To explore the various pharmacological actions and the molecular mechanisms behind them by which Chinese herbs tend to lower the risk of developing microvascular diabetic complications in retina and prevent its further progression. KEY FINDINGS: Several Chinese herbs, indeed, elicit potent anti-inflammatory, antioxidant, anti-angiogenic, anti-apoptotic, peroxisome proliferator-activated receptor-gamma receptor agonistic, platelet-activating factor antagonistic, aldose reductase inhibitory and various other beneficial pharmacological activities, required to counteract the pathological conditions prevalent in retina during diabetes...
January 26, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28123754/resource-use-associated-with-type-2-diabetes-in-africa-the-middle-east-south-asia-eurasia-and-turkey-results-from-the-international-diabetes-management-practice-study-idmps
#14
Juan J Gagliardino, Petar K Atanasov, Juliana C N Chan, Jean C Mbanya, Marina V Shestakova, Prisca Leguet-Dinville, Lieven Annemans
OBJECTIVE: Type 2 diabetes (T2D) and its complications form a global healthcare burden but the exact impact in some geographical regions is still not well documented. We describe the healthcare resource usage (HRU) associated with T2D in Africa, the Middle East, South Asia, Eurasia and Turkey. RESEARCH DESIGN AND METHODS: In the fifth wave of the International Diabetes Management Practices Study (IDMPS; 2011-2012), we collected self-reported and physician-reported cross-sectional data from 8156 patients from 18 countries across 5 regions, including different types of HRU in the previous 3-6 months...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28119515/association-of-pentraxin-3-gene-polymorphisms-with-susceptibility-to-diabetic-nephropathy
#15
Hong Zhu, Weihui Yu, Yuanyuan Xie, Hailing Zhang, Yan Bi, Dalong Zhu
BACKGROUND Diabetic nephropathy (DN) is a major microvascular complication of diabetes. Pentraxin 3 (PTX3) is a member of the acute-phase reactants superfamily and altered plasma levels of PTX3 are associated with DN. We performed a case-control study to analyze the relationship between single nucleotide polymorphisms (SNPs) in PTX3 and the risk for DN in patients with type 2 diabetes. MATERIAL AND METHODS The study included 135 DN patients, 155 non-diabetic nephropathy (NDN) patients, and 152 normal controls (NC) (N=442)...
January 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28117539/blood-pressure-regulation-determined-by-ambulatory-blood-pressure-profiles-in-children-and-adolescents-with-type-1-diabetes-mellitus-impact-on-diabetic-complications
#16
A Dost, S Bechtold-Dalla Pozza, E Bollow, R Kovacic, P Vogel, L Feldhahn, K O Schwab, R W Holl
BACKGROUND: The combination of high blood pressure and hyperglycemia contributes to the development of diabetic complications. Ambulatory monitoring of blood pressure (ABPM) is seen as standard to assess blood pressure (BP) regulation. OBJECTIVE: We evaluated 24-hour BP regulation in 3529 children with type 1 diabetes, representing 5.6% of the patients <20 years of age documented in the DPV registry, and studied the influence of BP parameters including pulse pressure (PP) and blood pressure variability (BPV) on microalbuminuria (MA) and diabetic retinopathy (DR)...
January 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28117535/high-hba1c-at-onset-cannot-be-used-as-a-predictor-for-future-metabolic-control-for-the-individual-child-with-type-1-diabetes-mellitus
#17
John Nilsson, Karin Åkesson, Lena Hanberger, Ulf Samuelsson
BACKGROUND: To study how metabolic control at onset of type 1 diabetes correlates to metabolic control and clinical parameters during childhood until transition from pediatric care to adult diabetes care. MATERIALS AND METHODS: Data at onset, three months, one, three, and five years after diagnosis and at transition, on HbA1c and clinical parameters, on 8084 patients in the Swedish pediatric quality registry, SWEDIABKIDS, were used. Of these patients, 26% had been referred to adult diabetes care by 2014...
January 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28112712/-pathophysiology-of-diabetic-nephropathy-a-literature-review
#18
REVIEW
Carlos Eduardo Meza Letelier, Camilo Alfredo San Martín Ojeda, José Javier Ruiz Provoste, Cristobal Jesus Frugone Zaror
Chronic kidney disease is a common complication of diabetes. Its importance lies in its high prevalence and future projection. It is associated with high health costs and global cardiovascular deterioration as well. The development of this disease pathophysiology is being studied and it is known that a series of complex molecular pathways determining a microvascular disease are involved. This review addresses the known pathways in the development of diabetic nephropathy aiming to improve the understanding of potential therapeutic targets that could be developed in the future...
January 12, 2017: Medwave
https://www.readbyqxmd.com/read/28110469/is-diabetic-skeletal-fragility-associated-with-microvascular-complications-in-bone
#19
REVIEW
Roberto Jose Fajardo
PURPOSE OF REVIEW: The objective of this literature review is to determine whether there are indications that microvascular complications occur in diabetic bone. Evidence definitively linking diabetic skeletal fragility with microvascular complications in bone remains elusive. RECENT FINDINGS: Circumstantial evidence, some recent and some lost to time, suggests that atherosclerotic vascular diseases such as peripheral arterial disease cause poor blood perfusion of bone and subsequent hypoxia and contribute to low bone density and high cortical porosity, patterns similar to some recently observed in diabetic subjects...
January 21, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28107340/association-of-diabetes-related-complications-with-heart-rate-variability-among-a-diabetic-population-in-the-uae
#20
Ahsan H Khandoker, Haitham M Al-Angari, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Al Safar, Herbert F Jelinek
Microvascular, macrovascular and neurological complications are the key causes of morbidity and mortality among type II diabetes mellitus (T2DM) patients. The aim of this study was to investigate the alterations of cardiac autonomic function of diabetic patients in relation to three types of diabetes-related complications. ECG recordings were collected and analyzed from 169 T2DM patients in supine position who were diagnosed with nephropathy (n = 55), peripheral neuropathy (n = 64) and retinopathy (n = 106) at two hospitals in the UAE...
2017: PloS One
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