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atherothrombosis

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https://www.readbyqxmd.com/read/29348025/pet-mr-imaging-of-malondialdehyde-acetaldehyde-epitopes-with-a-human%C3%A2-antibody-detects-clinically%C3%A2-relevant-atherothrombosis
#1
Max L Senders, Xuchu Que, Young Seok Cho, Calvin Yeang, Hannah Groenen, Francois Fay, Claudia Calcagno, Anu E Meerwaldt, Simone Green, Phuong Miu, Mark E Lobatto, Thomas Reiner, Zahi A Fayad, Joseph L Witztum, Willem J M Mulder, Carlos Pérez-Medina, Sotirios Tsimikas
BACKGROUND: Oxidation-specific epitopes (OSEs) are proinflammatory, and elevated levels in plasma predict cardiovascular events. OBJECTIVES: The purpose of this study was to develop novel positron emission tomography (PET) probes to noninvasively image OSE-rich lesions. METHODS: An antigen-binding fragment (Fab) antibody library was constructed from human fetal cord blood. After multiple rounds of screening against malondialdehyde-acetaldehyde (MAA) epitopes, the Fab LA25 containing minimal nontemplated insertions in the CDR3 region was identified and characterized...
January 23, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29335284/nitric-oxide-signaling-and-atherothrombosis-redux-evidence-from-experiments-of-nature-and-implications-for-therapy
#2
EDITORIAL
Joseph Loscalzo
No abstract text is available yet for this article.
January 16, 2018: Circulation
https://www.readbyqxmd.com/read/29325730/use-of-cardiovascular-polypills-for-the-secondary-prevention-of-cerebrovascular-disease
#3
J Masjuan, J Gállego, J M Aguilera, J F Arenillas, M Castellanos, F Díaz, J C Portilla, F Purroy
INTRODUCTION: There is little control of cardiovascular (CV) risk factors in secondary prevention after an ischaemic stroke, in part due to a lack of adherence to treatment. The CV polypill may contribute to proper treatment adherence, which is necessary for CV disease prevention. This study aimed to establish how and in what cases the CV polypill should be administered. METHODS: A group of 8 neurologists drafted consensus recommendations using structured brainstorming and based on their experience and a literature review...
January 8, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29304533/release-of-platelet-derived-sphingosine-1-phosphate-involves-multidrug-resistance-protein-4-mrp4-abcc4-and-is-inhibited-by-statins
#4
Katja Vogt, Shailaja Mahajan-Thakur, Robert Wolf, Susanne Bröderdorf, Conny Vogel, Andreas Böhm, Christoph A Ritter, Markus Gräler, Stefan Oswald, Andreas Greinacher, Heyo K Kroemer, Gabriele Jedlitschky, Bernhard H Rauch
Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism. A candidate transport protein is the multidrug resistance protein 4 (MRP4/ABCC4), an ATP-dependent transporter highly expressed in platelets. Furthermore, several statins are known to affect platelet functions and exhibit antithrombotic properties. This study determines the involvement of MRP4 in the transport of S1P and a possible interference by statins...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29303611/aldosterone-modulates-blood-homocysteine-and-cholesterol-in-coronary-artery-disease-patients-a-possible-impact-on-atherothrombosis
#5
K Karolczak, P Kubalczyk, R Glowacki, R Pietruszynski, C Watala
Aldosterone plays a key role in maintaining the homeostasis of the whole organism. Under some circumstances, aldosterone can contribute to the progression of cardiovascular diseases, including coronary artery disease. This study demonstrates that aldosterone associates negatively with some lipidogram parameters and positively with the concentration of homocysteine. This associations are characteristic for coronary artery disease and are not present in control subjects. The findings also indicate that in vitro aldosterone stimulates homocysteine production by rat adrenal glands, which may explain the associations observed with coronary artery disease...
January 5, 2018: Physiological Research
https://www.readbyqxmd.com/read/29301785/lp-a-lipoprotein-a-levels-predict-progression-of-carotid-atherosclerosis-in-subjects-with-atherosclerotic-cardiovascular-disease-on-intensive-lipid-therapy-an-analysis-of-the-aim-high-atherothrombosis-intervention-in-metabolic-syndrome-with-low-hdl-high-triglycerides
#6
Daniel S Hippe, Binh An P Phan, Jie Sun, Daniel A Isquith, Kevin O'Brien, John R Crouse, Todd Anderson, John Huston, Santica M Marcovina, Thomas S Hatsukami, Chun Yuan, Xue-Qiao Zhao
OBJECTIVE: To assess whether Lp(a) (lipoprotein(a)) levels and other lipid levels were predictive of progression of atherosclerosis burden as assessed by carotid magnetic resonance imaging in subjects who have been treated with LDL-C (low-density lipoprotein cholesterol)-lowering therapy and participated in the AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes). APPROACH AND RESULTS: AIM-HIGH was a randomized, double-blind study of subjects with established vascular disease, elevated triglycerides, and low HDL-C (high-density lipoprotein cholesterol)...
January 4, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29301628/platelet-derived-mrp-14-induces-monocyte-activation-in-patients-with-symptomatic-peripheral-artery-disease
#7
Rebecca Dann, Tarik Hadi, Emilie Montenont, Ludovic Boytard, Dornaszadat Alebrahim, Jordyn Feinstein, Nicole Allen, Russell Simon, Krista Barone, Kunihiro Uryu, Yu Guo, Caron Rockman, Bhama Ramkhelawon, Jeffrey S Berger
BACKGROUND: Peripheral artery disease (PAD), a diffuse manifestation of atherothrombosis, is a major cardiovascular threat. Although platelets are primary mediators of atherothrombosis, their role in the pathogenesis of PAD remains unclear. OBJECTIVES: The authors sought to investigate the role of platelets in a cohort of symptomatic PAD. METHODS: The authors profiled platelet activity, mRNA, and effector roles in patients with symptomatic PAD and in healthy controls...
January 2, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29295851/proteomic-profiling-for-cardiovascular-biomarker-discovery-in-orthostatic-hypotension
#8
Madeleine Johansson, Fabrizio Ricci, Nay Aung, Richard Sutton, Olle Melander, Artur Fedorowski
Orthostatic hypotension (OH) has been linked with higher incidence of cardiovascular disease, but little is known about the mechanisms behind this association. We aimed to identify cardiovascular disease biomarkers associated with OH through a proteomic profiling approach. Seven hundred seventy-eight patients with unexplained syncope or orthostatic intolerance underwent head-up tilt test and supine blood samples. Of these, 220 met diagnostic criteria of OH, and 179 demonstrated normal hemodynamic response during head-up tilt test...
January 2, 2018: Hypertension
https://www.readbyqxmd.com/read/29284569/epidemiology-of-stroke-in-costa-rica-a-7-year-hospital-based-acute-stroke-registry-of-1319-consecutive-patients
#9
Gabriel Torrealba-Acosta, Kenneth Carazo-Céspedes, Sy Han Chiou, Anthony Terrence O'Brien, Huberth Fernández-Morales
BACKGROUND: Limited data on stroke exist for Costa Rica. Therefore, we created a stroke registry out of patients with stroke seen in the Acute Stroke Unit of the Hospital Calderon Guardia. METHODS: We analyzed 1319 patients enrolled over a 7-year period, which incorporated demographic, clinical, laboratory, and neuroimaging data. RESULTS: The mean age of patients with stroke was 68.0 ± 15.5 years. Seven hundred twenty-five were men and the age range was 13-104 years...
December 25, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29276935/-rivaroxaban-for-secondary-prophylaxis-of-atherothrombosis-complications-in-patients-with-recent-acute-coronary-syndrome
#10
S S Sergeeva, T Y Kuznetsova, V V Kocherina, A N Malygin, S T Makarova, G N Belozerov, O V Ignatenko
No abstract text is available yet for this article.
October 2017: Kardiologiia
https://www.readbyqxmd.com/read/29238720/calcifying-matrix-vesicles-and-atherosclerosis
#11
REVIEW
Dimitry A Chistiakov, Veronika A Myasoedova, Alexandra A Melnichenko, Andrey V Grechko, Alexander N Orekhov
Artery calcification is a well-recognized predictor of late atherosclerotic complications. In the intima media, calcification starts with apoptosis of vascular smooth muscle cells (VSMCs) and the release of calcifying matrix vesicles with diameter of 0.5-15 μm that can be observed microscopically. In complicated plaques, calcification is generally less frequent. Calcifying vesicles are released by proatherosclerotic VSMCs into the collagen-rich matrix. The vesicles can penetrate into the intima media and protrude into the arterial lumen and thereby may represent a potential cause of atherothrombosis...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29236146/-atherothrombosis-novel-therapeutic-strategies
#12
O Soehnlein
Despite intensive scientific research over the past decades, atherosclerosis and atherothrombosis are the leading cause of mortality worldwide. During the recent past it has become clear that atherosclerosis is not merely a lipid-driven disease but a multifactorial process involving chronic inflammation of large arteries. This review article briefly outlines the mechanistic nature of atherosclerosis, presents a synopsis of the current state of the art treatment strategies and finally outlines several therapeutic options, which are in clinical and experimental testing...
December 13, 2017: Herz
https://www.readbyqxmd.com/read/29208626/the-effect-of-extended-release-niacin-on-markers-of-mineral-metabolism-in-ckd
#13
Rakesh Malhotra, Ronit Katz, Andrew Hoofnagle, Andrew Bostom, Dena E Rifkin, Ruth Mcbride, Jeffrey Probstfield, Geoffrey Block, Joachim H Ix
BACKGROUND AND OBJECTIVES: Niacin downregulates intestinal sodium-dependent phosphate transporter 2b expression and reduces intestinal phosphate transport. Short-term studies have suggested that niacin lowers serum phosphate concentrations in patients with CKD and ESRD. However, the long-term effects of niacin on serum phosphate and other mineral markers are unknown. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Trial was a randomized, double-blind, placebo-controlled trial testing extended release niacin in persons with prevalent cardiovascular disease...
January 6, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29189913/association-between-multimorbidity-and-mean-platelet-volume-in-diabetic-patients-with-acute-myocardial-infarction
#14
Bartosz Hudzik, Ilona Korzonek-Szlacheta, Janusz Szkodziński, Radosław Liszka, Andrzej Lekston, Barbara Zubelewicz-Szkodzińska, Mariusz Gąsior
AIMS: Diabetes mellitus (DM) is one of the most frequently detected conditions in multimorbid disease clusters. Platelet activation is one of the key mechanisms underlying atherothrombosis in acute myocardial infarction. Available data link mean platelet volume (MPV) to poor prognosis not only in cardiovascular and non-cardiovascular disease. Given the lack of research data on the association between disease clusters and MPV, we have set out to investigate the link between multimorbidity and MPV in diabetic patients with acute myocardial infarction...
November 30, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29186454/external-applicability-of-the-compass-trial-an-analysis-of-the-reduction-of-atherothrombosis-for-continued-health-reach-registry
#15
Arthur Darmon, Deepak L Bhatt, Yedid Elbez, Victor Aboyans, Sonia Anand, Jackie Bosch, Kelley R Branch, Stuart J Connolly, Leanne Dyal, John W Eikelboom, Keith A A Fox, Katalin Keltai, Jeffrey Probstfield, Salim Yusuf, Jérémie Abtan, Emmanuel Sorbets, Kim A Eagle, Gregory Ducrocq, Philippe Gabriel Steg
Aims: The aims of the present study were to describe the proportion of patients eligible for the COMPASS trial within the Reduction of Atherothrombosis for Continued Health (REACH) registry, the reasons for ineligibility, and to put in perspective the characteristics and outcomes of trial-eligible patients from the REACH registry compared with those of patients enrolled in the reference aspirin arm of the COMPASS trial. Methods and results: The COMPASS selection and exclusion criteria were applied to REACH patients with either coronary artery disease (CAD) or peripheral artery disease (PAD)...
November 23, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29167396/targeting-stub1-tissue-factor-axis-normalizes-hyperthrombotic-uremic-phenotype-without-increasing-bleeding-risk
#16
Moshe Shashar, Mostafa E Belghasem, Shinobu Matsuura, Joshua Walker, Sean Richards, Faisal Alousi, Keshab Rijal, Vijaya B Kolachalama, Mercedes Balcells, Minami Odagi, Kazuo Nagasawa, Joel M Henderson, Amitabh Gautam, Richard Rushmore, Jean Francis, Daniel Kirchhofer, Kumaran Kolandaivelu, David H Sherr, Elazer R Edelman, Katya Ravid, Vipul C Chitalia
Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue factor (TF) and aryl hydrocarbon receptor (AHR)] are being defined, the specific mechanisms that drive the thrombotic and bleeding risks are not fully understood. We now present an indolic solute-specific animal model, which focuses on solute-protein interactions and shows that indolic solutes mediate the hyperthrombotic phenotype across all CKD stages in an AHR- and TF-dependent manner...
November 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29149823/olive-oil-related-anti-inflammatory-effects-on-atherosclerosis-potential-clinical-implications
#17
Tanakal Wongwarawipat, Nikolaos Papageorgiou, Dimitrios Bertsias, Gerasimos Siasos, Dimitris Tousoulis
BACKGROUND AND OBJECTIVE: Atherosclerosis is characterized by a chronic low-grade inflammatory process which can result in atherothrombosis and a number of cardiovascular diseases (CVD). It is believed to be caused by multiple processes that involve inflammation and immunity. Mediterranean Diet (MedD) has been discovered to possess anti-inflammatory properties and associated with a reduction in the CVD risk and mortality. Its main component, extra-virgin olive oil (EVOO), is believed to be largely responsible for these effects and therefore, has been investigated in various studies...
2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29139042/obesity-and-altered-aspirin-pharmacology
#18
REVIEW
Nicholas B Norgard
Obesity is an independent risk factor for cardiovascular morbidity and mortality due to atherothrombotic events and represents a group of patients who are in need of optimized antithrombotic therapy. Central to the obesity-related risk of atherothrombosis is a pro-thrombotic state characterized by increased levels of coagulation factors, impaired fibrinolysis, and platelet hyper-reactivity, which results from the interaction among the features clustering in obesity: insulin resistance, inflammation, oxidative stress, and endothelial dysfunction...
November 14, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29099757/oxidative-stress-in-human-atherothrombosis-sources-markers-and-therapeutic-targets
#19
REVIEW
Jose Luis Martin-Ventura, Raquel Rodrigues-Diez, Diego Martinez-Lopez, Mercedes Salaices, Luis Miguel Blanco-Colio, Ana M Briones
Atherothrombosis remains one of the main causes of morbidity and mortality worldwide. The underlying pathology is a chronic pathological vascular remodeling of the arterial wall involving several pathways, including oxidative stress. Cellular and animal studies have provided compelling evidence of the direct role of oxidative stress in atherothrombosis, but such a relationship is not clearly established in humans and, to date, clinical trials on the possible beneficial effects of antioxidant therapy have provided equivocal results...
November 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29097390/differential-impact-of-serial-measurement-of-nonplatelet-thromboxane-generation-on-long-term-outcome-after-cardiac-surgery
#20
Nikolaos Kakouros, Tyler J Gluckman, John V Conte, Thomas S Kickler, Katherine Laws, Bruce A Barton, Jeffrey J Rade
BACKGROUND: Systemic thromboxane generation, not suppressible by standard aspirin therapy and likely arising from nonplatelet sources, increases the risk of atherothrombosis and death in patients with cardiovascular disease. In the RIGOR (Reduction in Graft Occlusion Rates) study, greater nonplatelet thromboxane generation occurred early compared with late after coronary artery bypass graft surgery, although only the latter correlated with graft failure. We hypothesize that a similar differential association exists between nonplatelet thromboxane generation and long-term clinical outcome...
November 2, 2017: Journal of the American Heart Association
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