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https://www.readbyqxmd.com/read/28522745/randomised-controlled-trial-of-stand-alone-tailored-emails-for-smoking-cessation
#1
J Lee Westmaas, Jeuneviette Bontemps-Jones, Peter S Hendricks, Jihye Kim, Lorien C Abroms
INTRODUCTION: Digital technology has created opportunities for delivering smoking cessation assistance at the population level. However, the efficacy of sending multiple, automated, tailored emails providing motivation, support and information for quitting is unknown. METHODS: Smokers planning to quit (n=1070) were randomly assigned to (1) 27 tailored cessation emails (deluxe email group (DEG)), (2) 3 to 4 tailored emails with links to downloadable booklets (basic email group (BEG)) or (3) a single non-tailored email (single email group (SEG))...
May 18, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28521782/combining-alcohol-interventions-with-tobacco-addictions-treatment-in-primary-care-the-combat-study-a-pragmatic-cluster-randomized-trial
#2
Nadia Minian, Dolly Baliunas, Laurie Zawertailo, Aliya Noormohamed, Norman Giesbrecht, Christian S Hendershot, Bernard Le Foll, Jürgen Rehm, Andriy Samokhvalov, Peter L Selby
BACKGROUND: Tobacco and alcohol use present multiplicative risk for aerodigestive cancers. Reducing alcohol consumption improves smoking cessation outcomes and reduces cancer risk. Risky alcohol consumption and smoking are often treated separately despite concurrent treatment potentially leading to better outcomes for each. However, no rapidly scalable program exists for combined interventions in primary care clinics spread across wide geographic areas. This cluster randomized trial aims to report on the effects of a novel clinical decision support system (CDSS) on intervention rates by primary care practitioners addressing risky alcohol use in a smoking cessation program...
May 18, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28521015/changes-in-alcohol-consumption-during-a-stop-smoking-attempt-and-differences-between-smokers-using-nicotine-replacement-and-smokers-using-varenicline
#3
Dunja Przulj, Peter Hajek, Sarah Snuggs, Hayden McRobbie
Introduction: Little is known about effects of smoking cessation on alcohol consumption. Varenicline reduces enjoyment of smoking and cigarette consumption and may also reduce enjoyment and consumption of alcohol. We conducted the first prospective examination of the effects of stopping smoking on alcohol enjoyment and consumption, and compared clients using varenicline and clients using nicotine replacement treatment (NRT). Methods: Audit of records from clients undergoing routine smoking cessation treatment inthree stop-smoking services in London, UK...
May 17, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28500373/effects-of-varenicline-versus-transdermal-nicotine-replacement-therapy-on-cigarette-demand-on-quit-day-in-individuals-with-substance-use-disorders
#4
Cara M Murphy, James MacKillop, Rosemarie A Martin, Jennifer W Tidey, Suzanne M Colby, Damaris J Rohsenow
RATIONALE: Cigarette demand is a behavioral economic measure of the relative value of cigarettes. Decreasing the value of cigarette reinforcement may help with quitting smoking. OBJECTIVES: This study aimed to evaluate the effects of initial use of varenicline (VAR) versus nicotine replacement therapy (NRT) on demand for cigarettes on quit day among smokers with substance use disorders (SUD) and to determine whether reduced demand was associated with subsequent abstinence from smoking at 1 and 3 months...
May 13, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28498504/varenicline-versus-nicotine-patch-with-brief-advice-for-smokers-with-substance-use-disorders-with-or-without-depression-effects-on-smoking-substance-use-and-depressive-symptoms
#5
Damaris J Rohsenow, Jennifer W Tidey, Rosemarie A Martin, Suzanne M Colby, Robert M Swift, Lorenzo Leggio, Peter M Monti
AIMS: Varenicline was compared with transdermal nicotine (NRT) for smokers with current substance use disorders (SUD) for effects on 3-month smoking abstinence (primary outcome) and, secondarily, on 3 and 6 month abstinence while adjusting for medication adherence, and on additional smoking and substance use outcomes. Moderation by major depressive disorder history (MDD) and adherence were investigated. DESIGN: Double-blind double-placebo controlled randomized design, stratifying by MDD, gender and nicotine dependence, with 3 and 6 months follow up...
May 12, 2017: Addiction
https://www.readbyqxmd.com/read/28490903/cardiovascular-risks-in-smokers-treated-with-nicotine-replacement-therapy-a-historical-cohort-study
#6
Jens Dollerup, Jørgen Vestbo, Tarita Murray-Thomas, Alan Kaplan, Richard J Martin, Emilio Pizzichini, Marcia M M Pizzichini, Anne Burden, Jessica Martin, David B Price
BACKGROUND: Previous research suggests exposure to nicotine replacement therapy (NRT) may be associated with an increased risk of cardiovascular disease (CVD). METHODS: Using data from the United Kingdom's Clinical Practice Research Datalink, this study aimed to evaluate CVD events and survival among individuals who attempted smoking cessation with the support of NRT compared with those aided by smoking cessation advice only. We studied CVD outcomes over 4 and 52 weeks in 50,214 smokers attempting to quit - 33,476 supported by smoking cessation advice and 16,738 with the support of NRT prescribed by their primary care physician...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28490757/transcriptome-and-metabolite-analysis-identifies-nitrogen-utilization-genes-in-tea-plant-camellia-sinensis
#7
Wei Li, Fen Xiang, Micai Zhong, Lingyun Zhou, Hongyan Liu, Saijun Li, Xuewen Wang
Applied nitrogen (N) fertilizer significantly increases the leaf yield. However, most N is not utilized by the plant, negatively impacting the environment. To date, little is known regarding N utilization genes and mechanisms in the leaf production. To understand this, we investigated transcriptomes using RNA-seq and amino acid levels with N treatment in tea (Camellia sinensis), the most popular beverage crop. We identified 196 and 29 common differentially expressed genes in roots and leaves, respectively, in response to ammonium in two tea varieties...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28486709/anhedonia-its-dynamic-relations-with-craving-negative-affect-and-treatment-during-a-quit-smoking-attempt
#8
Jessica W Cook, Stephanie T Lanza, Wanghuan Chu, Timothy B Baker, Megan E Piper
Introduction: Research shows that abstinence from tobacco leads to a withdrawal-related decrement in responsivity to nondrug rewards (ie, anhedonia). However, it remains unclear how anhedonia relates to other key withdrawal symptoms and withdrawal-related constructs over time. We analyzed ecological momentary assessment data to examine whether a decrement in response to rewards during a 10-day period following quitting shows a pattern of associations with other variables (ie, treatment, tobacco dependence, negative affect, and craving) that is consistent with anhedonia being a tobacco withdrawal symptom...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28485581/electrochemical-sensing-of-neurotoxic-agents-based-on-their-electron-transfer-promotion-effect-on-an-au-electrode
#9
Hiroshi Shimada, Shiori Noguchi, Masahiro Yamamoto, Katsuhiko Nishiyama, Yusuke Kitamura, Toshihiro Ihara
An electrochemical molecular sensor based on a new principle is reported. Nereistoxin (NRT, 4-N,N-dimethylamino-1,2-dithiolane), a naturally occurring neurotoxin (nicotinic acetylcholine receptor agonist), was adsorbed on an Au electrode via Au-S covalent bonding and accelerated the electron transfer between the electrode and the marker, ferricyanide anion. The contrast between the electrochemical responses obtained with the bare and NRT-modified Au electrodes was more pronounced at a low ionic strength of the supporting electrolyte, KCl...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28476261/smoking-cessation-care-provision-in-australian-alcohol-and-other-drug-treatment-services-a-cross-sectional-survey-of-staff-self-reported-practices
#10
Eliza Skelton, Flora Tzelepis, Anthony Shakeshaft, Ashleigh Guillaumier, Adrian Dunlop, Sam McCrabb, Kerrin Palazzi, Billie Bonevski
INTRODUCTION: Clinical practice guidelines recommend alcohol and other drug (AOD) services assess client's smoking status and offer smoking cessation care (SCC) to all smokers. The aim of this study was to examine Australian AOD program staff report of recommended SCC practices: assessment and recording of smoking status; and the provision of 9 types of SCC. The study also assessed how the decision to provide SCC is made and the AOD program service and AOD staff characteristics associated with the provision of SCC...
June 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28473506/cardiovascular-and-neuropsychiatric-risks-of-varenicline-and-bupropion-in-smokers-with-chronic-obstructive-pulmonary-disease
#11
Daniel Kotz, Wolfgang Viechtbauer, Colin R Simpson, Onno C P van Schayck, Robert West, Aziz Sheikh
BACKGROUND: Varenicline and bupropion are effective smoking cessation treatments, but there are concerns about their safety in smokers with COPD. OBJECTIVE: To investigate whether varenicline and bupropion are associated with serious adverse cardiovascular and neuropsychiatric events in smokers with COPD. METHODS: In a retrospective cohort study, we used data from 14 350 patients with COPD included in the QResearch database, which holds data from 753 National Health Service general practices across England...
May 4, 2017: Thorax
https://www.readbyqxmd.com/read/28458959/preoperative-radiotherapy-is-not-associated-with-increased-post-mastectomy-short-term-morbidity-analysis-of-77-902-patients
#12
Pablo A Baltodano, Myrna Eliann Reinhardt, José M Flores, Francis M Abreu, Anmol Chattha, Lyonell Kone, Carisa M Cooney, Michele A Manahan, Richard C Zellars, Gedge D Rosson
BACKGROUND: Neoadjuvant radiotherapy (NRT) enhances breast-conserving surgery outcomes, reducing local recurrence of breast cancer and increasing median survival. However, its effect on postoperative morbidity remains under-studied. We sought to assess the impact of NRT on 30-day postoperative morbidity after mastectomy. METHODS: We analyzed data from women undergoing mastectomy (with or without immediate reconstruction) using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) 2005-2011 datasets...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28449278/seroepidemiology-and-molecular-characterization-of-hepatitis-e-virus-infection-in-swine-and-occupationally-exposed-workers-in-punjab-india
#13
M Bansal, S Kaur, D Deka, R Singh, J P S Gill
Hepatitis E virus (HEV) has two discrete epidemiological patterns: waterborne epidemics in developing countries only, caused by HEV genotype I, and sporadic zoonotic outbreaks in developing and developed countries caused by genotypes III and IV. This study was designed to investigate seroprevalence, molecular detection and the characterization of HEV by nested RT-PCR in swine as well as the occupational risk to exposed human population in Punjab state of north-western India. The occupational risk-exposed group comprised of swine farmers (organized - mixed feed feeders and unorganized - swill feeders), slaughterhouse workers, sewage workers and veterinary internes...
April 27, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28399192/genome-wide-identification-classification-and-transcriptional-analysis-of-nitrate-and-ammonium-transporters-in-coffea
#14
Tiago Benedito Dos Santos, Joni Esrom Lima, Mariane Silva Felicio, João Danillo Moura Soares, Douglas Silva Domingues
Nitrogen (N) is quantitatively the main nutrient required by coffee plants, with acquisition mainly by the roots and mostly exported to coffee beans. Nitrate (NO3-) and ammonium (NH4+) are the most important inorganic sources for N uptake. Several N transporters encoded by different gene families mediate the uptake of these compounds. They have an important role in source preference for N uptake in the root system. In this study, we performed a genome-wide analysis, including in silico expression and phylogenetic analyses of AMT1, AMT2, NRT1/PTR, and NRT2 transporters in the recently sequenced Coffea canephora genome...
April 10, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28398690/use-of-nicotine-replacement-therapy-in-young-people-entering-custody-in-new-south-wales-australia
#15
Leigh Haysom, Dianne Lawrence, Donna Mellish, Peter Burns, Pariza Khale, Ariana Arulampalam, Catherine Stapylton
AIM: To describe the prevalence of nicotine dependence and acceptance of nicotine replacement therapy (NRT) in young people entering custody, where smoking is not allowed. METHODS: Cross-sectional study in 2013. SETTING: All New South Wales Juvenile Justice Centres. PARTICIPANTS: Incarcerated youth, aged 12-21 years. MAIN EXPOSURES: gender, age, ethnicity, cannabis use. MAIN OUTCOMES: rates of smoking, cannabis use, nicotine dependence, NRT acceptance...
April 11, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28395126/mapping-the-trajectory-of-nucleophilic-substitution-at-silicon-using-a-peri-substituted-acenaphthyl-scaffold
#16
Emanuel Hupf, Marian Olaru, Ciprian I Rat, Christian B Hübschle, Enno Lork, Simon Grabowsky, Stefan Mebs, Jens Beckmann
The nucleophilic substitution reaction of second order (SN2) at a silicon atom is scrutinized using snapshots along a pseudo-reaction coordinate. Phosphine and fluoride represent both attacking and leaving groups in the modeled SN2 reaction. In the experimentally obtained 5-Ph2P-Ace-6-SiMe2F (1) the phosphine moiety and the fluorosilane moiety are forced into immediate proximity through an acenaphthyl scaffold, i.e. they exhibit peri-interactions that serve as the model of the reactant ion-molecule complex and starting point for a theoretical PES scan...
April 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28386232/transcriptomic-profiles-reveal-the-interactions-of-cd-zn-in-dwarf-polish-wheat-triticum-polonicum-l-roots
#17
Yi Wang, Xiaolu Wang, Chao Wang, Fan Peng, Ruijiao Wang, Xue Xiao, Jian Zeng, Houyang Kang, Xing Fan, Lina Sha, Haiqin Zhang, Yonghong Zhou
Different intra- or interspecific wheat show different interactions of Cd/Zn. Normally, Zn has been/being widely utilized to reduce the Cd toxicity. In the present study, the DPW seedlings exhibited strong Cd tolerance. Zn and Cd mutually inhibited their uptake in the roots, showed antagonistic Cd/Zn interactions. However, Zn promoted the Cd transport from the roots to shoots, showed synergistic. In order to discover the interactive molecular responses, a transcriptome, including 123,300 unigenes, was constructed using RNA-Sequencing (RNA-Seq)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28376818/smokers-making-a-quit-attempt-using-e-cigarettes-with-or-without-nicotine-or-prescription-nicotine-replacement-therapy-impact-on-cardiovascular-function-isme-nrt-a-study-protocol
#18
Markos Klonizakis, Helen Crank, Anil Gumber, Leonie S Brose
BACKGROUND: The estimated number of cigarette smokers in the world is 1.3 billion, expected to rise to 1.7 billion by 2025, with 10 million smokers living in the U.K. Smoking is the leading, preventable death-cause worldwide, being responsible for almost 650,000 deaths in the E.U. annually. A combination of pharmacological interventions, including nicotine replacement therapy, bupropion and varenicline, and behavioural support is the most effective approach to smoking cessation. However, even the best methods have high relapse rates of approximately 75% within 6 months...
April 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28345689/can-there-be-a-multi-bond-between-noble-gas-and-metal-a-theoretical-study-of-f2xemof2
#19
Kunqi Gao, Li Sheng
A new noble gas compound containing a Xe-Mo double bond, F2XeMoF2, was theoretically constructed and studied based on DFT and ab initio calculations. The CCSD(T)-calculated Xe-Mo bond length of 2.518 Å was comparable to the standard value of 2.56 Å. The bonding energy (32.3 kcal mol(-1)) was even higher than that of the Xe-Au bond in the well-known XeAuF complex (24.1 kcal mol(-1)). The result of natural bond orbital (NBO) analysis indicates that there is a σ-bond and a π-bond between the Xe and Mo atoms in F2XeMoF2...
March 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28342700/nicotine-replacement-therapy-in-patients-with-aneurysmal-subarachnoid-hemorrhage-systematic-review-of-the-literature-and-survey-of-canadian-practice
#20
REVIEW
Ricky D Turgeon, Stephano J Chang, Charlotte Dandurand, Peter A Gooderham, Camille Hunt
Tobacco smoke increases the risk of aneurysmal subarachnoid hemorrhage (SAH), as well as complications such as vasospasm. Most patients presenting with aneurysmal SAH smoke, and many survivors continue to smoke after discharge. Neurosurgeons often hesitate to use nicotine replacement therapy (NRT) during hospitalization of patients with SAH due to concerns of inducing vasospasm. We aimed to evaluate the safety and efficacy, and patterns of use of NRT in smokers hospitalized for SAH. We performed a systematic review of MEDLINE, CENTRAL, Embase, and unpublished sources of literature to October 2016 for randomized and observational studies comparing exposure to non-exposure of smoking cessation products in the acute phase of aneurysmal SAH...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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