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https://www.readbyqxmd.com/read/28738270/chemical-structure-and-correlation-analysis-of-hiv-1-nnrt-and-nrt-inhibitors-and-database-curated-published-inhibition-constants-with-chemical-structure-in-diverse-datasets
#1
Birgit Viira, Alfonso T García-Sosa, Uko Maran
Human immunodeficiency virus (HIV-1) reverse transcriptase is a major target for designing anti-HIV drugs. Developed inhibitors are divided into non-nucleoside analog reverse-transcriptase inhibitors (NNRTIs) and nucleoside analog reverse-transcriptase inhibitors (NRTIs) depending on their mechanism. Given that many inhibitors have been studied and for many of them binding affinity constants have been calculated, it is beneficial to analyze the chemical landscape of these families of inhibitors and correlate these inhibition constants with molecular structure descriptors...
June 24, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28723477/accuracy-of-self-reported-smoking-exposure-among-bladder-cancer-patients-undergoing-surveillance-at-a-tertiary-referral-center
#2
Alan E Thong, Stacey Petruzella, Irene Orlow, Emily C Zabor, Behfar Ehdaie, Jamie S Ostroff, Bernard H Bochner, Helena Furberg Barnes
BACKGROUND: Smoking is a risk factor for developing bladder cancer (BCa). Even though continued exposure after diagnosis may adversely affect prognosis, patients may be reluctant to disclose to their physicians that they are currently smoking, leading to inaccurate reporting of exposure and missed opportunities to deliver smoking-cessation advice and treatment in the context of cancer care. OBJECTIVE: We examined the extent of misclassification of recent smoking exposure among patients undergoing BCa surveillance...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720080/long-term-effectiveness-of-mailed-nicotine-replacement-therapy-study-protocol-of-a-randomized-controlled-trial-5-year-follow-up
#3
Vladyslav Kushnir, Peter Selby, Laurie Zawertailo, Rachel F Tyndale, Scott T Leatherdale, John A Cunningham
BACKGROUND: Our group recently completed a randomized controlled trial, evaluating the efficacy of providing 5 weeks of free nicotine replacement therapy (NRT; in the form of the nicotine patch) by expedited postal mail without behavioral assistance to regular adult smokers interested in receiving it. The findings revealed that mailed provision of nicotine patches resulted in more than a doubling of quit rates at a six-month follow-up compared to a no intervention control group. While this trial provided evidence for the effectiveness of mailed nicotine patches in promoting cessation, the findings speak only to the short term effectiveness of this approach...
July 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28709877/impact-of-duration-of-neoadjuvant-radiation-on-rectal-cancer-survival-a-real-world-multi-center-retrospective-cohort-study
#4
Omar Abdel-Rahman, Aalok Kumar, Hagen F Kennecke, Caroline H Speers, Winson Y Cheung
BACKGROUND: The utility of neoadjuvant radiotherapy (nRT) for the treatment of stage II and III rectal cancer is well-established. However, the optimal duration of nRT in this setting remains controversial. Using a population-based cohort of patients with stage II and III rectal cancer (RC) treated with curative intent, our aims were to (1) examine the patterns of nRT use and (2) explore the relationship between different nRT schedules and survival in the real-world setting. METHODS: This is a multi-center retrospective cohort study based on population-based data from 5 regional comprehensive cancer centers in British Columbia, Canada...
June 23, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28697411/electron-velocity-map-imaging-and-theoretical-study-on-cuxh-x-o-and-s-anions
#5
Zhengbo Qin, Hui Wang, Yangdi Ren, Xianfeng Zheng, Zhifeng Cui, Zichao Tang
Vibrationally resolved photoelectron spectra of CuOH(-) and CuSH(-) have been determined via velocity map imaging method to investigate the transitions of X(1)A'←X(2)A' at 532nm. Adiabatic detachment energies of CuOH(-) and CuSH(-) are assigned to 0.995(12) and 1.098(12) eV, respectively. Combined theoretical calculations with Franck-Condon simulations, it allows extracting the vibrational frequencies in neutral, which yields 629(32) cm(-1) with CuO stretching mode and 387(24) cm(-1) with CuS stretching mode for CuXH (X=O and S)...
July 4, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28694200/the-prevention-and-treatment-of-smoking-and-tobacco-use-during-pregnancy-in-selected-indigenous-communities-in-high-income-countries-of-usa-canada-australia-and-new-zealand-an-evidence-based-review
#6
REVIEW
Gillian S Gould, Ling Li Lim, Joerg Mattes
IMPORTANCE: Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and bab(ies). Tobacco use during pregnancy has reduced in high-income countries; but not for Indigenous women in Australia, New Zealand, the United States, and Canada. APPROACH/AIM: This evidence-based review focusses on tobacco use among Indigenous pregnant women in high-income countries, who share a history of European colonisation...
July 7, 2017: Chest
https://www.readbyqxmd.com/read/28693456/impact-of-large-scale-distribution-and-subsequent-use-of-free-nicotine-patches-on-primary-care-physician-interaction
#7
Vladyslav Kushnir, Beth A Sproule, John A Cunningham
BACKGROUND: Large-scale distribution efforts of free nicotine replacement therapy (NRT) have been documented to be cost-effective interventions for increasing smoking quit rates. However, despite nearly a dozen studies evaluating their effectiveness, none have examined whether free NRT provision promotes further primary care help-seeking and the impact that it may have on cessation efforts. METHODS: In the context of a randomized controlled trial, a secondary analysis was conducted on 1000 adult regular smokers randomized to be mailed a 5-week supply of nicotine patches or to a no intervention control group...
July 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28689764/wula-voices-of-aboriginal-women-on-barriers-to-accepting-smoking-cessation-support-during-pregnancy-findings-from-a-qualitative-study
#8
M Bovill, M Gruppetta, Y Cadet-James, M Clarke, B Bonevski, G S Gould
AIM: To gather Aboriginal women's stories of smoking and becoming pregnant to identify the barriers in accepting smoking cessation support during pregnancy. METHODS: Qualitative data were collected through use of yarning methodology between August 2015 and January 2016 by an Aboriginal Researcher with experience in social and community services. A short on-line survey was used to collect quantitative data. Interviews only recorded the therapeutic yarning process, which ranged from 9 to 45min duration, averaging 30min...
July 6, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28677401/applying-a-social-ecological-framework-to-factors-related-to-nicotine-replacement-therapy-for-adolescent-smoking-cessation
#9
Jessica L King, Julie W Merten, Tzu-Jung Wong, Jamie L Pomeranz
OBJECTIVE: This systematic review synthesizes factors related to nicotine replacement therapy (NRT) use among adolescents seeking to quit smoking, using the social-ecological model as a guiding framework. DATA SOURCE: Searches of PubMED, ProQuest, EBSCOhost, and ERIC were conducted in July 2016. STUDY INCLUSION AND EXCLUSION CRITERIA: Original studies of cigarette smokers younger than 18 years that discussed NRT were included. DATA EXTRACTION: Two reviewers individually extracted study purpose, sample, design, and results...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/28647546/a-review-of-the-effects-of-very-low-nicotine-content-cigarettes-on-behavioral-and-cognitive-performance
#10
Diana R Keith, Allison N Kurti, Danielle R Davis, Ivori A Zvorsky, Stephen T Higgins
The present systematic review examines whether very low nicotine content (VLNC) cigarettes ameliorate withdrawal-induced impairments in behavioral/cognitive performance. PubMed, PsycInfo, and Web of Science were searched for performance effects of VLNC cigarettes. For inclusion, reports had to be in English, published in a peer-reviewed journal through June 2017, examine VLNC cigarettes (<0.2mg nicotine yield), include ≥2hour smoking abstinence or reduced nicotine exposure, and examine performance. 19 of 1243 articles reviewed met inclusion criteria...
June 21, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28644619/long-bonding-in-hngcn-nc-ng-noble-gas-molecules-an-nbo-nrt-investigation
#11
Guiqiu Zhang, Shengnan Zhang, Dezhan Chen
Recently, Weinhold et al. put forward one new concept of σ̂-type long-bonding and applied it to the comprehension of halogen noble-gas hydrides HNgY (Ng = noble gas; Y = halogen) bonding. The present study extends this new concept into HNgX (X = CN, NC) pseudohalogen molecules. At the B3LYP and CCSD(T) levels of theory, we perform natural bond orbital (NBO) and natural resonance theory (NRT) studies on the HNgX molecules and compare them with the previous results for HNgY molecules. The NBO/NRT results clearly reveal that each of the HNgX, but not the HHeCN, HNeCN, and HNeNC molecules, is composed of three leading resonance structures: two ω-bonding structures H-Ng(+):X(-), H:(-)Ng(+)-X and one long-bonded structure H(∧)X...
July 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28637262/qualitative-exploration-of-a-smoking-cessation-trial-for-people-living-with-hiv-in-south-africa
#12
Nandita Krishnan, Joel Gittelsohn, Alexandra Ross, Jessica Elf, Sandy Chon, Raymond Niaura, Neil Martinson, Jonathan E Golub
Introduction: In South Africa, people living with HIV (PLWH) have a high prevalence of smoking, which undermines the beneficial effects of antiretroviral therapy (ART). However, little is known about barriers to smoking cessation and what interventions work for PLWH in this setting. Methods: A randomized trial comparing intensive anti-smoking counseling versus counseling and nicotine replacement therapy (NRT) was recently concluded in Klerksdorp, South Africa. In a post-trial follow-up, 23 in-depth interviews with patients and one focus group discussion with counselors from the trial were conducted...
June 16, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28631924/insight-into-the-bonding-mechanism-and-the-bonding-covalency-in-noble-gas-noble-metal-halides-an-nbo-nrt-investigation
#13
Guiqiu Zhang, Lei Fu, Hong Li, Xuchan Fan, Dezhan Chen
The bonding between noble gas and noble metal halide like hydrogen bonding (H-bonding) motivates us to investigate the bonding mechanism and the bonding covalency in NgMX (Ng = He, Ne, Ar, Kr, Xe, Rn; M = Cu, Ag, Au; X = F, Cl, Br, I) complexes using natural bond orbital (NBO) and natural resonance theory (NRT) methods. In this study, we introduce the new resonance bonding model in H-bonding into NgMX bonding. We provide strong evidence for resonance bonding involving two important resonance structures: Ng: M-X ↔ Ng(+)-M :X(-) in each of NgMX complexes, originating in the nNg → σ*MX hyperconjugative interaction...
July 3, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28624760/how-do-smoking-cessation-medicines-compare-with-respect-to-their-neuropsychiatric-safety-a-protocol-for-a-systematic-review-network-meta-analysis-and-cost-effectiveness-analysis
#14
Kyla H Thomas, Deborah Caldwell, Michael N Dalili, David Gunnell, Marcus R Munafò, Matt Stevenson, Nicky J Welton
INTRODUCTION: Cigarette smoking is one of the leading causes of early death in the UK and worldwide. Public health guidance recommends the use of varenicline, bupropion and nicotine replacement therapy (NRT) as smoking cessation aids in the UK. Additionally, the first electronic cigarette has been licensed for use as a smoking cessation medicine. However, there are ongoing concerns about the safety of these medicines. We present a protocol for a systematic review and network meta-analysis (NMA) to determine how these smoking cessation medicines compare to each other with respect to their neuropsychiatric safety in adult smokers...
June 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28601398/gaba-receptors-and-t-type-ca-2-channels-crosstalk-in-thalamic-networks
#15
REVIEW
Nathalie Leresche, Régis C Lambert
Although the thalamus presents a rather limited repertoire of GABAergic cell types compare to other CNS area, this structure is a privileged system to study how GABA impacts neuronal network excitability. Indeed both glutamatergic thalamocortical (TC) and GABAergic nucleus reticularis thalami (NRT) neurons present a high expression of T-type voltage-dependent Ca(2+) channels whose activation that shapes the output of the thalamus critically depends upon a preceding hyperpolarisation. Because of this strict dependence, a tight functional link between GABA mediated hyperpolarization and T-currents characterizes the thalamic network excitability...
June 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28595236/comparison-of-serum-cytokine-levels-in-obese-and-lean-men-effects-of-nonlinear-periodized-resistance-training-and-obesity
#16
Mahmoud Nikseresht
This study examined the capacity of nonlinear resistance training (NRT) to alter some cytokines and markers of insulin resistance in men who are obese. An additional aim was to compare these variables between obese and lean men. Age- and fitness-matched obese men were randomly allocated to NRT (n=12) and control (CON, n=10) groups. An age- and fitness-matched control group of lean men (n=11) were also recruited for baseline comparison. The NRT (12 weeks, 3 d/wk, 5-11 exercises) performed at different intensities (40-95% of IRM) with flexible periodization...
June 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28591583/distinct-thalamic-reticular-cell-types-differentially-modulate-normal-and-pathological-cortical-rhythms
#17
Alexandra Clemente-Perez, Stefanie Ritter Makinson, Bryan Higashikubo, Scott Brovarney, Frances S Cho, Alexander Urry, Stephanie S Holden, Matthew Wimer, Csaba Dávid, Lief E Fenno, László Acsády, Karl Deisseroth, Jeanne T Paz
Integrative brain functions depend on widely distributed, rhythmically coordinated computations. Through its long-ranging connections with cortex and most senses, the thalamus orchestrates the flow of cognitive and sensory information. Essential in this process, the nucleus reticularis thalami (nRT) gates different information streams through its extensive inhibition onto other thalamic nuclei, however, we lack an understanding of how different inhibitory neuron subpopulations in nRT function as gatekeepers...
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28576892/study-protocol-of-a-pragmatic-randomised-controlled-pilot-trial-clinical-effectiveness-on-smoking-cessation-of-traditional-and-complementary-medicine-interventions-including-acupuncture-and-aromatherapy-in-combination-with-nicotine-replacement-therapy
#18
Soobin Jang, Sunju Park, Bo-Hyoung Jang, Yu Lee Park, Ju Ah Lee, Chung-Sik Cho, Ho-Yeon Go, Yong Cheol Shin, Seong-Gyu Ko
INTRODUCTION: Nicotine dependence is a disease, and tobacco use is related to 6 million deaths annually worldwide. Recently, in many countries, there has been growing interest in the use of traditional and complementary medicine (T&CM) methods, especially acupuncture, as therapeutic interventions for smoking cessation. The aim of this pilot study is to investigate the effectiveness of T&CM interventions on smoking cessation. METHODS AND ANALYSIS: The STOP (Stop Tobacco Programme using traditional Korean medicine) study is designed to be a pragmatic, open-label, randomised pilot trial...
June 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28559379/neural-entrainment-to-the-beat-the-missing-pulse-phenomenon
#19
Idan Tal, Edward W Large, Eshed Rabinovitch, Yi Wei, Charles E Schroeder, David Poeppel, Elana Zion Golumbic
Most humans have a near-automatic inclination to tap, clap, or move to the beat of music. The capacity to extract a periodic beat from a complex musical segment is remarkable, as it requires abstraction from the temporal structure of the stimulus. It has been suggested that nonlinear interactions in neural networks result in cortical oscillations at the beat frequency, and that such entrained oscillations give rise to the percept of a beat or a pulse. Here we tested this neural resonance theory using MEG recordings as female and male individuals listened to 30 s sequences of complex syncopated drumbeats designed so that they contain no net energy at the pulse frequency when measured using linear analysis...
June 28, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28556464/tobacco-harms-nicotine-pharmacology-and-pharmacologic-tobacco-cessation-interventions-for-women
#20
REVIEW
L Kim Baraona, Dawn Lovelace, Julie L Daniels, Linda McDaniel
Firsthand and secondhand tobacco use is linked to a multitude of harmful illnesses, adverse perinatal outcomes, and death. Cessation attempts among women may be hampered by their unique biologic response to nicotine. Current research has revealed epigenetic changes from intrauterine nicotine exposure that have intergenerational consequences. Multiple studies have demonstrated the efficacy of various pharmacologic tobacco cessation interventions in conjunction with behavioral counseling. Based on this evidence, the US Preventative Services Task Force (USPSTF) 2015 guideline recommends pharmacologic therapy for all nonpregnant persons who smoke in addition to behavioral counseling...
May 2017: Journal of Midwifery & Women's Health
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