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Molecular mechanism of malignant cachexia

Ana Isabel Padrão, Ana Cristina Corrêa Figueira, Ana Rocha-Faustino, Adelina Gama, Maria Margarida Loureiro, Maria João Neuparth, Daniel Moreira-Gonçalves, Rui Vitorino, Francisco Amado, Lúcio Lara Santos, Paula A Oliveira, José Alberto Duarte, Rita Ferreira
AIM: Exercise training has been suggested as a non-pharmacological approach to prevent skeletal muscle wasting and improve muscle function in cancer cachexia. However, little is known about the molecular mechanisms underlying such beneficial effect. In the present study we aimed to, firstly, examine the contribution of TWEAK signalling to cancer-induced skeletal muscle wasting and, secondly, evaluate whether long-term exercise alters TWEAK signalling and prevents muscle wasting. METHODS: Female Sprague-Dawley rats were randomly assigned to control and exercise groups...
May 26, 2016: Acta Physiologica
Lei Yuan, Jun Han, Qingyang Meng, Qiulei Xi, Qiulin Zhuang, Yi Jiang, Yusong Han, Bo Zhang, Jing Fang, Guohao Wu
Muscle atrophy F-Box (MAFbx)/atrogin-1 and muscle ring-finger-1 (MuRF-1) have been identified as two muscle-specific E3 ubiquitin ligases that are highly expressed in skeletal muscle during muscle atrophy. However, the role of muscle-specific E3 ubiquitin ligases during the process of muscle atrophy of cancer cachexia remains largely unknown. In the present study, we analyzed the expression of atrogin-1 and MuRF-1 in the skeletal muscle of patients with malignant and benign disease. The possible mechanisms were studied both in a colon 26-induced cancer cachexia mouse model and in tumor necrosis factor-α (TNF-α) induced atrophy C2C12 cells...
May 2015: Oncology Reports
Chen Bing, Paul Trayhurn
Profound loss of adipose and other tissues is a hallmark of cancer cachexia, a debilitating condition associated with increased morbidity and mortality. Fat loss cannot be attributable to reduced appetite alone as it precedes the onset of anorexia and is much more severe in experimental models of cachexia than in food restriction. Morphological examination has shown marked remodelling of adipose tissue in cancer cachexia. It is characterised by the tissue containing shrunken adipocytes with a major reduction in cell size and increased fibrosis in the tissue matrix...
November 2009: Proceedings of the Nutrition Society
J Bachmann, H Friess, M E Martignoni
Cachexia is a term used to describe the poor status of a patient suffering from a benign disease (Crohn's disease, chronic heart and kidney failure) as well as from a malignant disease. Cachexia has an important impact on the survival and morbidity in patients with cancer. The aim of this study is to elucidate the pathophysiology in cancer cachexia with a special emphasis on pancreatic cancer. The dramatic weight loss in malignant diseases is due to anorexia resulting in malnutrition and is characterised by a progressive loss of muscle and fat tissue...
December 2008: Zeitschrift Für Gastroenterologie
Massimo Fanelli, Roberta Sarmiento, Domenico Gattuso, Guido Carillio, Barbara Capaccetti, Angelo Vacca, Aldo Maria Roccaro, Giampietro Gasparini
Experimental studies have demonstrated that thalidomide (Thal), a drug developed as a sedative, has antitumoural properties. The possible antitumour mechanisms of action involve: inhibition of angiogenesis, cytokine-mediated pathways, modulation of adhesion molecules, inhibition of cyclooxygenase-2 and stimulation of immuno response. Therefore, Thal is under clinical evaluation in oncology. This paper provides an overview of the data currently available in literature regarding, in terms of activity and toxicity, the use of Thal in cancer patients...
July 2003: Expert Opinion on Investigational Drugs
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