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https://www.readbyqxmd.com/read/28943926/combination-of-galectin-3-ck19-and-hbme-1-immunostaining-improves-the-diagnosis-of-thyroid-cancer
#1
Vanessa Arcolia, Fabrice Journe, Florence Renaud, Emmanuelle Leteurtre, Hans-Joachim Gabius, Myriam Remmelink, Sven Saussez
Currently, fine-needle aspiration is the most frequently used pre-operative technique for diagnosis of malignant thyroid tumors, however, pathologists are unable to reach efficient and accurate differential diagnoses between benign and malignant thyroid nodules. To aid in resolving this issue, immunohistochemistry for galectins (gal)-1, -3, -7, -8, cytokeratin 19 (CK19), Hector Battifora Mesothelial Epitope-1 (HBME-1) and thyroid peroxidase (TPO) was performed on two tissue microarrays composed of 66 follicular adenomas (FA) and 66 papillary carcinomas (PC)...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943576/sarcoidosis-with-pancreatic-mass-endobronchial-nodules-and-miliary-opacities-in-the-lung
#2
Shun Matsuura, Yasutaka Mochizuka, Kyohei Oishi, Koichi Miyashita, Hyogo Naoi, Eisuke Mochizuki, Shinichiro Mikura, Masaru Tsukui, Naoki Koshimizu, Akihiko Ohata, Takahumi Suda
Sarcoidosis affects multiple organs and rarely has unusual manifestations. A 78-year-old woman was referred to our hospital for coughing symptoms. A chest computed tomography (CT) scan revealed bilateral diffuse miliary patterns and right pleural effusion. Bronchoscopy showed multiple nodules in the carina and the bronchus intermedius. A CT scan of her abdomen revealed hypovascular lesions involving the pancreatic head and body. A transbronchial lung biopsy, bronchial mucosal biopsy, and endoscopic ultrasound-guided fine-needle aspiration of the pancreatic mass demonstrated non-caseating granulomas...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28941855/diagnosis-of-clinically-suspected-and-unsuspected-tubercular-lymphadenopathy-by-cytology-culture-and-smear-microscopy
#3
Vivek Gupta, Arvind Bhake
BACKGROUND: Tubercular lymphadenopathy (TBLN) accounts for 20-40% cases of extrapulmonary tuberculosis. But the common presenting symptoms of tuberculosis like fever, cough, weight loss, fatigue, and night sweats are not always associated with tuberculosis lymphadenopathy, thereby, making its diagnosis difficult. Our aim was to study if Fine Needle Aspiration Cytology (FNAC) combined with Zeihl Neelsen stain and culture for Mycobacterium tuberculosis bacilli could improve the diagnostic accuracy in patients clinically suspected and unsuspected for tubercular lymphadenitis...
October 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28941185/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-implications-for-the-risk-of-malignancy-rom-in-the-bethesda-system-for-reporting-thyroid-cytopathology-tbsrtc
#4
Haijun Zhou, Zubair W Baloch, Ritu Nayar, Tommaso Bizzarro, Guido Fadda, Deepti Adhikari-Guragain, Joseph Hatem, Luigi M Larocca, Julia Samolczyk, Jamie Slade, Esther Diana Rossi
BACKGROUND: The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk of malignancy (ROM) mostly in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories. In this multi-institutional, retrospective study, the authors investigated variations in the impact of an NIFTP diagnosis on the associated ROM for each TBSRTC category with an emphasis on the influence of pathologist and institutional diagnostic thresholds on the ROM...
September 20, 2017: Cancer
https://www.readbyqxmd.com/read/28940588/mediastinal-ectopic-thyroid-diagnosed-by-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-report-of-three-cases
#5
Ayperi Ozturk, Tugba Cicek, Zafer Aktas, Funda Demirag, Aydin Yilmaz
An ectopic thyroid gland results from the abnormal migration of the thyroid in the course of its development. Primary ectopic mediastinal thyroid is very rare and occurs in less than 1% of all goiters that can be surgically excised. Ectopic thyroid tissue has a characteristic sonographic appearance as smooth-bordered, homogeneous, hypoechoic tissue with fine specular echoes. We report 3 cases of mediastinal ectopic thyroid diagnosed by endobronchial ultrasound-guided transbrochial needle aspiration biopsy.
September 22, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28940135/ectopic-retroperitoneal-adrenocortical-carcinoma-in-the-setting-of-lynch-syndrome
#6
Jesse P Wright, Kathleen W Montgomery, Joshua Tierney, Jill Gilbert, Carmen C Solórzano, Kamran Idrees
Adrenocortical carcinoma (ACC) is rare within the adult population. Ectopic ACC proves even rarer. This variant is formed by cortical fragments arrested during embryologic migration. ACC is also known to be associated with several genetic syndromes and has recently been linked to Lynch syndrome in 3% of cases. We present the case of a 68-year-old male with a confirmed diagnosis of Lynch syndrome secondary to a germline MSH2 mismatch-repair gene-mutation who presented with 2 months history of non-specific abdominal pain...
September 22, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28937510/advancements-in-staging-and-imaging-for-penile-cancer
#7
Sarah R Ottenhof, Andrew R Leone, Simon Horenblas, Philippe E Spiess, Erik Vegt
PURPOSE OF REVIEW: We review recent advancements in staging and imaging of penile cancer, including surveillance after therapy. RECENT FINDINGS: For cN0 patients, the sentinel lymph node biopsy is currently considered the preferred way for invasive staging. It has largely replaced other modalities such as staging inguinal lymphadenectomy. Its diagnostic value increases when combined with other staging modalities such as ultrasound with fine-needle aspiration cytology (US-FNAC) or fluorodeoxyglucose-PET with computed tomography (PET/CT)...
September 20, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28937392/fine-needle-aspiration-cytology-of-leishmanial-lymphadenitis-in-a-hiv-reactive-patient
#8
Biswajit Biswas, Subrata Pal
No abstract text is available yet for this article.
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28934992/breast-cancer-metastases-to-the-thyroid-gland-an-uncommon-sentinel-for-diffuse-metastatic-disease-a-case-report-and-review-of-the-literature
#9
Agata M Plonczak, Aimee N DiMarco, Roberto Dina, Dorothy J Gujral, Fausto F Palazzo
BACKGROUND: Metastases to the thyroid are rare. The most common primary cancer to metastasize to the thyroid is renal cell carcinoma, followed by malignancies of the gastrointestinal tract, lungs, and skin, with breast cancer metastases to the thyroid being rare. Overall, the outcomes in malignancies that have metastasized to the thyroid are poor. There are no prospective studies addressing the role of surgery in metastatic disease of the thyroid. Isolated thyroidectomy has been proposed as a local disease control option to palliate and prevent the potential morbidity of tumor extension related to the airway...
September 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28932542/the-value-of-cell-block-based-on-fine-needle-aspiration-for-lung-cancer-diagnosis
#10
Zhengwei Dong, Hui Li, Jun Zhou, Wei Zhang, Chunyan Wu
BACKGROUND: Computed tomography (CT)-guided percutaneous lung fine needle aspiration (FNA) is a convenient method to obtain samples from pulmonary lesions. FNA has a lower rate of complications than the use of a core needle biopsy, but is more difficult for the diagnosis of cytological samples. We use cell block (CB) and immunocytochemistry (ICC) to improve the accuracy of cytological diagnoses based on CT-guided percutaneous lung FNA. METHODS: We collected 526 cytological samples obtained using CT-guided percutaneous lung FNA at Shanghai Pulmonary Hospital from May 2015 to October 2015...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932166/salivary-duct-carcinoma-of-accessory-parotid
#11
Mohammed A Al-Hashim, Nasser A Al-Jazan
Accessory parotid gland (APG) is seen in around 21%-56% of individuals. Tumors of accessory parotid are uncommon with an incidence rate of 1%-8% of all parotid tumors. Ductal carcinoma of APG is rare, so no reported incidence was seen in the literature. However, salivary gland ductal carcinoma is reported to be 1% of all salivary gland neoplasms. We report here a case of salivary duct carcinoma of APG. Clinical presentation, investigation, and management are discussed. A 69-year-old female presented with a history of the left cheek progressive swelling of 6 years' duration...
September 2017: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/28932084/characterizing-gastrointestinal-stromal-tumors-and-evaluating-neoadjuvant-imatinib-by-sequencing-of-endoscopic-ultrasound-biopsies
#12
Per Hedenström, Bengt Nilsson, Akif Demir, Carola Andersson, Fredrik Enlund, Ola Nilsson, Riadh Sadik
AIM: To evaluate endoscopic ultrasound (EUS)-guided biopsies for the pretreatment characterization of gastrointestinal stromal tumors (GIST) to personalize the management of patients. METHODS: All patients with lesions suspected to be GIST who were referred for EUS-sampling at a tertiary Swedish center were eligible for inclusion 2006-2015. During the observational study phase (2006-2011), routine fine-needle-aspiration (EUS-FNA) was performed. In 2012-2015, we converted to an interventional, randomized protocol with dual sampling EUS-FNA and fine-needle-biopsy-sampling (EUS-FNB) for all lesions...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28932037/fine-needle-aspiration-cytology-of-cysticercosis-in-submandibular-gland
#13
Vaneet Kaur Sandhu, Upender Sharma, Navtej Singh, Geetika Goyal
Fine-needle aspiration cytology (FNAC) has emerged as simple, minimally invasive, low-cost, outpatient diagnostic modality for the evaluation of nodules caused by parasites. Cysticercosis is caused by larval stage of Taenia solium, pork tapeworm. It is endemic in Southeast Asia, Latin America and South Africa. We report a case of cysticercosis in a 25-year-old male who presented with painless swelling of submandibular gland which was diagnosed on FNAC. The patient was recommended antihelminthic therapy which resulted in complete resolution of the swelling...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28932028/cytological-spectrum-of-salivary-gland-lesions-and-their-correlation-with-epidemiological-parameters
#14
Vaneet Kaur Sandhu, Upender Sharma, Navtej Singh, Arun Puri
BACKGROUND: The role fine-needle aspiration (FNA) in the diagnosis of salivary gland lesions has evolved over the years. Although clinical and radiological parameters help to narrow the differential diagnosis the tissue diagnosis still remains the gold standard. MATERIALS AND METHODS: This study is from January 2013 to December 2015 in our Department of Pathology where 170 salivary gland lesions were aspirated. The aim of the present study was to analyze adequacy rate in relation to the size of lesion and to evaluate varied cytological spectrum of salivary gland lesions with emphasis on differential diagnosis and to correlate cytological diagnosis with age, gender and anatomical site...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28930825/acinar-cell-carcinoma-of-the-pancreas-presenting-as-diffuse-pancreatic-enlargement-two-case-reports-and-literature-review
#15
Yaping Luo, Guilan Hu, Yanru Ma, Ning Guo, Fang Li
RATIONALE: Pancreatic acinar cell carcinoma (ACC) is a rare malignant tumor of exocrine pancreas. It is typically a well-marginated large solid mass arising in a certain aspect of the pancreas. Diffuse involvement of ACC in the pancreas is very rare, and may simulate pancreatitis in radiological findings. We report 2 cases of ACC presenting as diffuse enlargement of the pancreas due to tumor involvement without formation of a distinct mass. PATIENT CONCERNS: The patients consisted of a 41-year-old man with weight loss and a 77-year-old man who was asymptomatic...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28928976/disseminated-tuberculosis-presenting-as-cold-abscess-of-the-thyroid-gland-a-case-report
#16
Kiran Dv, Karthik Gunasekaran, Ajay Kumar Mishra, Ramya Iyyadurai
Tubercular involvement of the thyroid gland is a rare entity. Tuberculosis of thyroid gland can present as cold abscess, multinodular goitre, acute abscess or generalized goitre. Clinically, these patients can be euthyroid, hypothyroid or hyperthyroid. Diagnosis is made by fine needle aspiration and demonstration of acid fast bacilli. Here, we report the case of a 46-year-old male who presented with disseminated extrapulmonary tuberculosis with obstructive hydrocephalus and cold abscess of the thyroid gland...
September 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28928103/pancreatic-metastasis-from-non-small-cell-lung-cancer-diagnosed-using-endoscopic-ultrasound-guided-fine-needle-aspiration-biopsy-a-case-report
#17
Nobuyasu Kurihara, Hajime Saito, Hiroshi Nanjo, Hayato Konno, Yoshihiro Minamiya
A 56-year-old man presented with a chest computed tomography (CT) finding of a right upper lobe nodule, which was diagnosed using brush cytology as adenocarcinoma stage IB (cT2aN0M0). Repeat CT scan for preoperative evaluation revealed a small, slightly hypodense spot in the pancreatic body, which was diagnosed as pancreatic metastasis from lung cancer using endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNAB). Because of the presence of distant metastasis, surgical resection was deferred and chemotherapy was chosen instead...
September 19, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28927297/clinical-value-of-the-vtiq-technology-in-the-differential-diagnosis-of-superficially-enlarged-lymph-nodes
#18
Zhifei Ben, Shanshan Gao, Wenjing Wu, Saijun Chen, Shuping Fu, Jianli Zhang, Yunwen Chen
Background Lymph node enlargement is a common clinical finding in clinical practice with different treatment strategies. Purpose To investigate the application of Virtual Touch Image Quantification (VTIQ) to diagnose benign and malignant superficial enlarged lymph nodes. Material and Methods Between December 2015 and August 2016, 116 superficial enlarged lymph nodes were examined by VTIQ. Maximum (Vmax), minimum (Vmin), and average (Vmean) shear wave velocities (SWV) were obtained from the lymph nodes and from normal muscular tissues (Vn) located at the same level and within 5 mm from the target lymph node...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28927073/surgical-treatment-of-parapharyngeal-space-tumors-a-report-of-29-cases
#19
Kei Ijichi, Shingo Murakami
The present study aimed to establish a strategy for parapharyngeal space (PPS) tumor surgery based on preoperative symptoms, clinical signs, imaging and histological examination. A retrospective cohort study was conducted with 29 adult patients who underwent surgery for primary PPS tumors from 2008-2015. The following data was obtained: Preoperative symptoms of the patient, histological type of the tumor, surgical approach and complications. Of the 29 patients who underwent surgery to remove a PPS tumor, 16 presented with neurogenic tumors and 13 with salivary gland tumors...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925594/pharyngoesophageal-diverticula-simulating-thyroid-nodules-an-unusual-occurrence-with-unique-features
#20
Karen K Nauschuetz, Lorna L Ogden, Cherry E Starling, Mohammad J Saleh, Allan C Golding, S Thomas Traweek
Pharyngoesophageal diverticula (PED) of the Zenker's and Killian-Jamieson types arise in close proximity to the thyroid gland, and may rarely be confused with a thyroid nodule on ultrasonography. In this brief report, we detail the cytologic, clinical, and radiologic findings of three PED that were thought to be thyroid nodules, and were subjected to fine-needle aspiration (FNA). The patients were females with an age range of 51-64 years. All three patients had multiple thyroid nodules, and two patients reported symptoms attributable to the diverticulum...
September 19, 2017: Diagnostic Cytopathology
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