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https://www.readbyqxmd.com/read/28546075/antimicrobial-storage-and-antibiotic-knowledge-in-the-community-a-cross-sectional-pilot-study-in-north-western-angola
#1
Joana Cortez, Edite Rosário, João E Pires, João Taborda Lopes, Moisés Francisco, Erika Vlieghe, Miguel Brito
BACKGROUND: Antimicrobials are drugs that were once lifesavers and mainly curative. Nowadays their value is increasingly under pressure because of the fast and worldwide emergence of antimicrobial resistance, which, in low resources settings, frequently occurs in microorganisms that are likely to be transmitted in the community. METHODS: A cross-sectional pilot study including 102 households within the 10th HDSS round in Dande, Bengo Province, Angola. RESULTS: From the total 102 households piloted, 77...
May 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28543087/death-due-to-complications-of-bowel-obstruction-following-raw-poppy-seed-ingestion
#2
Leah M Schuppener, Robert F Corliss
Eating poppy seeds can cause a positive urine drug screen, but it is unknown whether ingesting large quantities can result in opiate intoxication or toxicity. A 54-year-old woman with intractable vomiting was found unresponsive at home and later pronounced dead. At autopsy, a cast-like large bowel obstruction composed of poppy seeds was identified. Postmortem blood morphine level was < 10 ng/mL. Cause of death was determined to be complications of a bowel obstruction secondary to poppy seed ingestion. Deaths related to eating poppy seeds have not been described in the literature...
May 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28515014/hiv-and-the-criminalisation-of-drug-use-among-people-who-inject-drugs-a-systematic-review
#3
Kora DeBeck, Tessa Cheng, Julio S Montaner, Chris Beyrer, Richard Elliott, Susan Sherman, Evan Wood, Stefan Baral
BACKGROUND: Mounting evidence suggests that laws and policies prohibiting illegal drug use could have a central role in shaping health outcomes among people who inject drugs (PWID). To date, no systematic review has characterised the influence of laws and legal frameworks prohibiting drug use on HIV prevention and treatment. METHODS: Consistent with PRISMA guidelines, we did a systematic review of peer-reviewed scientific evidence describing the association between criminalisation of drug use and HIV prevention and treatment-related outcomes among PWID...
May 12, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28508402/risk-factors-for-human-immunodeficiency-virus-among-blood-donors-in-cameroon-evidence-for-the-design-of-an-africa-specific-donor-history-questionnaire
#4
Claude T Tagny, Georges Nguefack-Tsague, Diderot Fopa, Celestin Ashu, Estel Tante, Pauline Ngo Balogog, Olivier Donfack, Dora Mbanya, Syria Laperche, Edward Murphy
BACKGROUND: In sub-Saharan Africa improving the deferral of at-risk blood donors would be a cost-effective approach to reducing transfusion-transmitted human immunodeficiency virus (HIV) infections. We performed a pilot case-control study to identify the risk factors for HIV infection and to develop an adapted donor history questionnaire (DHQ) for sub-Saharan Africa. STUDY DESIGN AND METHODS: We recruited 137 HIV-positive donors (cases) and 256 HIV-negative donors (controls) and gathered risk factor data using audio computer-assisted self-interview...
May 15, 2017: Transfusion
https://www.readbyqxmd.com/read/28499382/the-association-between-residential-eviction-and-syringe-sharing-among-a-prospective-cohort-of-street-involved-youth
#5
Andreas Pilarinos, Mary Clare Kennedy, Ryan McNeil, Huiru Dong, Thomas Kerr, Kora DeBeck
BACKGROUND: Syringe sharing is a high-risk practice associated with the transmission of infectious diseases, such as HIV and HCV. While youth who contend with housing instability are known to be more likely to engage in high-risk substance use, the potential relationship between being evicted from housing and syringe sharing has not been examined. This study assessed whether residential eviction was associated with syringe sharing among street-involved youth in Vancouver, Canada. METHODS: Data were derived from the At-Risk Youth Study (ARYS), a prospective cohort of street-involved youth who use drugs age 14-26 in Vancouver, Canada...
May 12, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28488989/spice-y-kidney-failure-a-case-report-and-systematic-review-of-acute-kidney-injury-attributable-to-the-use-of-synthetic-cannabis
#6
REVIEW
Ceyda Zarifi, Shuchi Vyas
INTRODUCTION: Spice is a synthetic cannabinoid that is readily available for purchase in smoke shops at relatively low cost. Spice is not detectable upon routine drug screening, making it an increasingly popular new street drug. CASE REPORT: A 21-year-old man presented with new-onset seizures. During the next 2 days, he developed uncontrollable hypertension, agitation, respiratory failure requiring intubation, pulmonary hypertension, and acute kidney injury (AKI) with a maximum blood urea nitrogen/creatinine level of 54/7...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28488087/comparison-of-three-popular-methods-for-recruiting-young-persons-who-inject-drugs-for-interventional-studies
#7
Melissa G Collier, Richard S Garfein, Jazmine Cuevas-Mota, Eyasu H Teshale
Persons who inject drugs (PWID) are at risk for adverse health outcomes as a result of their drug use, and the resulting social stigma makes this a difficult population to reach for interventions aimed at reducing morbidity and mortality. During our study of adult PWID aged ≤40 years living in San Diego during 2009 and 2010, we compared three different sampling methods: respondent-driven sampling (RDS), venue-based sampling at one syringe exchange program (SEP), and street-based outreach. We compared demographic, socioeconomic, health, and behavioral factors and tested participants for HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) and compared across the three methods...
May 9, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28464942/-getting-out-of-downtown-a-longitudinal-study-of-how-street-entrenched-youth-attempt-to-exit-an-inner-city-drug-scene
#8
Rod Knight, Danya Fast, Kora DeBeck, Jean Shoveller, Will Small
BACKGROUND: Urban drug "scenes" have been identified as important risk environments that shape the health of street-entrenched youth. New knowledge is needed to inform policy and programing interventions to help reduce youths' drug scene involvement and related health risks. The aim of this study was to identify how young people envisioned exiting a local, inner-city drug scene in Vancouver, Canada, as well as the individual, social and structural factors that shaped their experiences...
May 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28464808/a-comparison-of-recommendations-and-received-treatment-for-mood-and-anxiety-disorders-in-a-representative-national-sample
#9
Benjamin A R Woolf, Jeanne V A Williams, Dina H Lavorato, Andrew G M Bulloch, Scott B Patten
BACKGROUND: The exact nature of treatment and management recommendations made, and received, for mood and anxiety disorders in a community population is unclear. In addition, there is limited evidence on the impact of recommendations on actual receipt of treatment or implementation of management strategies. We aim to describe the frequency with which specific recommendations were made and implemented; and thus assess the size of any gap between the recommendation and implementation of treatments and management strategies...
May 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28455844/open-probe-fast-gc-ms-combining-ambient-sampling-ultra-fast-separation-and-in-vacuum-ionization-for-real-time-analysis
#10
Uri Keshet, Tal Alon, Alexander B Fialkov, Aviv Amirav
An Open Probe inlet was combined with a low thermal mass ultra-fast gas chromatograph (GC), in-vacuum electron eonization (EI) ion source and a mass spectrometer (MS) of GC-MS for obtaining real time analysis with separation. The Open Probe enables ambient sampling via sample vaporization in an oven that is open to room air and the ultra-fast GC provides ~30 s separation while if no separation is required it can act as a transfer line with 2-3 s sample transfer time. Sample analysis is as simple as touching the sample, pushing the sample holder into the open probe oven and getting the results in 30 s...
April 28, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28446690/antimalarial-efficacy-of-mmv390048-an-inhibitor-of-plasmodium-phosphatidylinositol-4-kinase
#11
Tanya Paquet, Claire Le Manach, Diego González Cabrera, Yassir Younis, Philipp P Henrich, Tara S Abraham, Marcus C S Lee, Rajshekhar Basak, Sonja Ghidelli-Disse, María José Lafuente-Monasterio, Marcus Bantscheff, Andrea Ruecker, Andrew M Blagborough, Sara E Zakutansky, Anne-Marie Zeeman, Karen L White, David M Shackleford, Janne Mannila, Julia Morizzi, Christian Scheurer, Iñigo Angulo-Barturen, María Santos Martínez, Santiago Ferrer, Laura María Sanz, Francisco Javier Gamo, Janette Reader, Mariette Botha, Koen J Dechering, Robert W Sauerwein, Anchalee Tungtaeng, Pattaraporn Vanachayangkul, Chek Shik Lim, Jeremy Burrows, Michael J Witty, Kennan C Marsh, Christophe Bodenreider, Rosemary Rochford, Suresh M Solapure, María Belén Jiménez-Díaz, Sergio Wittlin, Susan A Charman, Cristina Donini, Brice Campo, Lyn-Marie Birkholtz, Kirsten K Hanson, Gerard Drewes, Clemens H M Kocken, Michael J Delves, Didier Leroy, David A Fidock, David Waterson, Leslie J Street, Kelly Chibale
As part of the global effort toward malaria eradication, phenotypic whole-cell screening revealed the 2-aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs. Stemming from this series, we found that the derivative, MMV390048, lacked cross-resistance with current drugs used to treat malaria. This compound was efficacious against all Plasmodium life cycle stages, apart from late hypnozoites in the liver. Efficacy was shown in the humanized Plasmodium falciparum mouse model, and modest reductions in mouse-to-mouse transmission were achieved in the Plasmodium berghei mouse model...
April 26, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28445899/evidence-based-guidelines-for-the-pharmacologic-management-of-methamphetamine-dependence-relapse-prevention-chronic-methamphetamine-related-and-comorbid-psychiatric-disorders-in-post-acute-settings
#12
Roland Härtel-Petri, Anne Krampe-Scheidler, Wolf-Dietrich Braunwarth, Ursula Havemann-Reinecke, Peter Jeschke, Winfried Looser, Stephan Mühlig, Ingo Schäfer, Norbert Scherbaum, Lydia Bothe, Corinna Schaefer, Willem Hamdorf
The increasing abuse of the street drug crystal meth (methamphetamine) in many countries worldwide has resulted in a growing demand to treat patients who have acquired a methamphetamine-related disorder. The results of a systematic literature search which led to the consensus-based recommendations by the Working Group of the German Agency for Quality in Medicine (Ärztliches Zentrum für Qualität in der Medizin - ÄZQ) are presented. Pharmacological treatments were reviewed in 58 out of the 103 publications included...
May 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28440070/chiral-analysis-of-amphetamines-in-hair-by-liquid-chromatography-tandem-mass-spectrometry-compliance-monitoring-of-attention-deficit-hyperactivity-disorder-adhd-patients-under-elvanse%C3%A2-therapy-and-identification-after-controlled-low-dose-application
#13
Tina M Binz, Elena Williner, Petra Strajhar, Patrick C Dolder, Matthias E Liechti, Markus R Baumgartner, Thomas Kraemer, Andrea E Steuer
Amphetamine (AMP) is used as illicit drug but also for the treatment of attention deficit hyperactivity disorder (ADHD). Respective drugs most often contain the enantiomer (S)-AMP as active compound or (S)-AMP is formed from the prodrug lisdexamfetamine (Elvanse®) whereas the illicit drug is usually traded as racemate ((R/S)-AMP). A differentiation between the use of the medically prescribed drug and the abuse of illicit street amphetamine is of great importance e.g. in retrospective consumption monitoring by hair analysis...
April 24, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28412676/investigation-of-sub-health-status-of-neonates-in-heping-street-region-beijing-and-analysis-on-related-risk-factors
#14
Chen Jie, Shi Mai, Li Qiuju, Ye Fang, Liu Fang, Fan Qinying, Zhang Yong, Wang Lin
To investigate sub-health status of neonates in Heping Street Region and related risk factors. Then, 7436 maternal women admitted to hospital in Heping Street Region, Beijing were enrolled from October 2013 to September 2015, including 293 women, who gave birth to sub-health neonates. Questionnaire survey was conducted to collect maternal age, education degree, experiences and income, occupation, life habit, condition in pregnancy, condition in perinatal period, adverse reaction in pregnancy, etc. Finally, 281 effective questionnaires were regained with effective regain rate of 95...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28398897/book-reviews-great-ormond-street-handbook-of-paediatrics-2nd-edn-edited-by-stephan-strobel-lewis-spitz-stephen-d-marks-crc-press-2016-price-%C3%A2-63-99-pp-736-isbn-9781482222791-stroke-medicine-2nd-edn-hugh-markus-anthony-pereira-geoffrey-cloud-oxford-university
#15
https://www.readbyqxmd.com/read/28374665/using-self-report-surveys-at-the-beginning-of-service-to-develop-multi-outcome-risk-models-for-new-soldiers-in-the-u-s-army
#16
A J Rosellini, M B Stein, D M Benedek, P D Bliese, W T Chiu, I Hwang, J Monahan, M K Nock, M V Petukhova, N A Sampson, A E Street, A M Zaslavsky, R J Ursano, R C Kessler
BACKGROUND: The U.S. Army uses universal preventives interventions for several negative outcomes (e.g. suicide, violence, sexual assault) with especially high risks in the early years of service. More intensive interventions exist, but would be cost-effective only if targeted at high-risk soldiers. We report results of efforts to develop models for such targeting from self-report surveys administered at the beginning of Army service. METHODS: 21 832 new soldiers completed a self-administered questionnaire (SAQ) in 2011-2012 and consented to link administrative data to SAQ responses...
April 4, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28370697/-selecting-appraising-recommending-and-using-mobile-applications-apps-in-nursing
#17
EDITORIAL
Caleb Ferguson, Debra Jackson
It's more than likely that a patient, their family member or a colleague may have recently asked you "Is there an app for that?" Mobile technology is inescapable. It is pervasive in almost every aspect of daily life. Wherever we look, people are often hunched over and fully immersed by a small 6 x 3 inch screen, whether it be walking on the street, travelling on the bus, at the coffee shop or in the clinic waiting room. Mobile devices have infiltrated most aspects of our lives and offer quick, adaptive tech-based solutions to many previously administrative, repetitive or otherwise time-consuming tasks...
March 31, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28343062/the-material-moral-and-affective-worlds-of-dealing-and-crime-among-young-men-entrenched-in-an-inner-city-drug-scene
#18
Danya Fast, Jean Shoveller, Thomas Kerr
A large body of previous research has elucidated how involvement in drug dealing and crime among marginalized urban youth who use drugs is shaped by the imperatives of addiction and survival in the context of poverty. However, a growing body of research has examined how youth's involvement in these activities is shaped by more expansive desires and moralities. In this paper, we examine the material, moral, and affective worlds of loosely gang affiliated, street level dealing and crime among one group of young men in Vancouver, Canada...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28336736/identifying-possible-reasons-why-female-street-sex-workers-have-poor-drug-treatment-outcomes-a-qualitative-study
#19
Nikki Jeal, John Macleod, Chris Salisbury, Katrina Turner
AIMS: To explore street sex workers (SSWs) views and experiences of drug treatment, in order to understand why this population tend to experience poor drug treatment outcomes. DESIGN: In-depth interviews. SETTING: Bristol, UK. PARTICIPANTS: 24 current and exited SSWs with current or previous experience of problematic use of heroin and/or crack cocaine. FINDINGS: Participants described how feeling unable to discuss their sex work in drug treatment groups undermined their engagement in the treatment process...
March 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28334473/history-of-being-in-government-care-associated-with-younger-age-at-injection-initiation-among-a-cohort-of-street-involved-youth
#20
Brittany Barker, Thomas Kerr, Huiru Dong, Evan Wood, Kora DeBeck
INTRODUCTION AND AIMS: Compared to the general population of youth, health-related disparities experienced by youth exposed to the child welfare system are well documented. Amongst these vulnerabilities are elevated rates of substance use, including injection drug use; however, less is known about when these youth transition to this high-risk behaviour. We sought to assess whether having a history of government care is associated with initiating injection drug use before age 18. DESIGN AND METHODS: Between September 2005 and May 2014, data were derived from the At-Risk Youth Study, a cohort of street-involved youth who use illicit drugs in Vancouver, Canada...
March 23, 2017: Drug and Alcohol Review
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