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autoinmune disease

Jimena Sanz-Bueno, Elena Gallo, Dolores Caro-Gutiérrez, Araceli Sánchez-Gilo, Marta Gutiérrez Pascual, Laura Rojas-Scheffer, Francisco Javier Vicente-Martín
El pénfigo foliáceo es una enfermedad autoinmune ampollosa debida a la producción de autoanticuerpos frente a la desmogleína 1. Presentamos el caso de un paciente con psoriasis y pénfigo foliáceo agravado por enalapril y amlodipino, con buena respuesta de ambas patologías a la terapia con adalimumab.Pemphigus foliaceus is a blistering autoimmune disease related to the production of autoantibodies against desmoglein 1. We present a patient with psoriasis and pemphigus foliaceus aggravated by enalapril and amlodipine intake, with successful response of both conditions to adalimumab therapy...
October 15, 2017: Dermatology Online Journal
J Canora, M García, F Mitjavila, G Espinosa, S Suárez, R González-León, B Sopeña, R Boldova, A Castro, G Ruiz-Irastorza
INTRODUCTION: Patient registries are useful tools for assessing rare diseases. Our objective is to present the Spanish registry of patients with systemic lupus erythematosus (Registro español de pacientes con lupus eritematoso sistémico, RELES). PATIENTS AND METHODS: RELES was started in 2008 as an observational, prospective, multicentre cohort registry that included patients from the time they were diagnosed. The registry's objective is to analyse the incidence and noninflammatory complications of systemic lupus erythematosus (SLE)...
January 2017: Revista Clínica Española
Araneda Constanza Damm, Villagra Matías Molina, Faúndez Giancarlo Schiappacasse, Arriagada Claudio Cortés
Celiac sprue (CS) is an autoinmune desease caused by gliadin intake. The exposure to this protein produces damage of the intestinal mucosae, primarily of the duodenum and yeyunum, causing different symptoms and diverse imaging findings. The objective of this review is to show a pictorial essay of the main findings of CS and its complications in barited fluroscopy, computed tomography and magnetic resonance. We show different images of patients with certified diagnosis of CS. In summary, these imaging modalities are useful for the diagnosis and follow up of patients with CS, as well as for the detection of complications...
2014: Acta Gastroenterologica Latinoamericana
Mónica Fernández Castro, Jose Luis Andreu, Carlos Sánchez-Piedra, Víctor Martínez Taboada, Alejandro Olivé, José Rosas, Fernando Sánchez-Alonso
OBJECTIVE: To describe the objectives and methods of the Spanish Society of Rheumatology primary Sjögren syndrome (pSS) registry (SJOGREN-SER) METHODS: This is a multicenter descriptive transversal study of a cohort of pSS patients fulfilling European/American consensus criteria collected from Rheumatology clinics all over Spain. Patients were included by randomisation from an anonymised list provided by every department. Data were collected by reviewing clinical records and an interviewing the patients...
July 2016: Reumatología Clinica
V T Ivashkinl, A F Sheptulina, K L Raĭkhelson, E A Losik, K V Ivashkin, A V Okhlobystin, E K Baranskaia, E A Polouvektova, O S Shifrin
Autoimmune diseases of digestive system refer to pathological conditions, caused by autoimmune mechanisms, and their etiology remains unknown. This is a group of relatively rare diseases, however, during the last years a marked tendency towards the raise in incidence andprevalence is observed, which led to an increase in number of clinical investigations on etiology, pathogenesis, and, accordingly, development of new diagnostic methods and therapies. Results of such trials shown, for example, that the pathogenesis of chronic cholestatic liver diseases is associated with nuclear receptors function, while the main etiological and pathogenic factor of inflammatory bowel diseases represents gut microbiota...
2015: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
Francisco Reyes-Baraona, Romina Andino, Juan Eduardo Carrasco, Camila Arriagada, Silvia Guerrero
Linear IgA bullous dermatosis is a rare acquired autoinmune vesiculobullous disease characterized by linear IgA deposit on the dermo-epidermal basement membrane observed with direct inmunofluorescence. The characteristic lesions are vesicles and tense serous bullae, which most often are grouped giving a "cluster of jewels" appearance. Differential diagnosis must be established with other autoimmune dermatosis, such as dermatitis herpetiformis and bullous pemphigoid. Dapsone is the first line therapy, with excellent response in a short period...
April 2014: Archivos Argentinos de Pediatría
Iñigo Rúa-Figueroa, Francisco Javier López-Longo, Jaime Calvo-Alén, María Galindo-Izquierdo, Estíbaliz Loza, M Jesús García de Yebenes, José M Pego-Reigosa
OBJECTIVE: To describe the objectives, design and methods of the Spanish Society of Rheumatology systemic lupus erythematosus (SLE) registry (RELESSER). METHODS: Multicenter, hospital-based registry, with retrospective collection of data from a large representative sample of adult patients with SLE (1997 ACR criteria) attending Spanish rheumatology services. The registry includes demographic data, frequent and infrequent (<1%) clinical manifestations, information about activity, damage, severity, comorbidity, treatments and mortality, collecting 359 variables per patient, with highly standardized definitions...
January 2014: Reumatología Clinica
Marcela Saeb-Lima, Yann Charli-Joseph, Elva Dalia Rodríguez-Acosta, Judith Domínguez-Cherit
Neutrophilic dermatoses have long been known to be associated with autoinmune systemic diseases. Recently, a small number of cases of a disorder distinct from Sweet syndrome or bullous lupus erythematosus (LE) have been described as specifically related to systemic LE under diverse terms, including nonbullous neutrophilic dermatosis, nonbullous neutrophilic LE, and Sweet-like neutrophilic dermatosis. We describe 7 patients that developed urticarial lesions in the context of a known or concurrently diagnosed autoimmune connective tissue disease...
August 2013: American Journal of Dermatopathology
M Ramos-Casals, G Ruiz-Irastorza, J Jiménez-Alonso, M A Khamashta
Biological therapies are based on the administration of various types of synthetic molecules related to the immune response. Their use has spread in recent years to the field of systemic autoimmune diseases, particularly to systemic lupus erythematosus (SLE). Until 2011, these diseases were not included in the therapeutic indications approved by international regulatory agencies. Therefore, the use of biological therapies was restricted to clinical trials and to compassionate use for cases refractory to standard treatments (off-label use), which require the approval of the Health Ministry...
January 2013: Revista Clínica Espanõla
Gonzalo de Las Heras Castaño, Marcos López Hoyos
No abstract text is available yet for this article.
December 2011: Revista Española de Enfermedades Digestivas
Cándido Díaz-Lagares, Rafael Belenguer, Manuel Ramos-Casals
OBJECTIVE: To analyze published evidence about adalimumab use in autoimmune diseases. METHODS: Systematic review of MEDLINE database of citations included from January 1990 to December 2008 employing the terms "adalimumab" and the different systemic autoimmune diseases. RESULTS: Our search identified 241 potentially relevant citations. 154 were retrieved for detailed evaluation. Finally, 18 were selected as relevant, including 54 patients...
May 2010: Reumatología Clinica
Manuel Ramos-Casals, Cándido Díaz-Lagares, Munther A Khamashta et al.
No abstract text is available yet for this article.
March 12, 2011: Medicina Clínica
L Pallarés Ferreres, M Ramos-Casals
No abstract text is available yet for this article.
March 2009: Farmacia Hospitalaria
Luis Ricardo Rodrigo Sáez
Celiac disease is a unique autoimmune disorder, because the environmental precipitant factor is known. It is gluten, the major storage protein of wheat and similar grains. Originally was considered a rare malabsorption syndrome of childhood, but nowadays is recognized a common condition, that affects to 1% of the general population, all over the world', involves to all different races, may be diagnosed at any age, and affects to many organ systems. Therapy for the disease is a gluten-free-diet that must be strict and long-term...
2008: Anales de la Real Academia Nacional de Medicina
Pedro Emilio Bermejo, Aurora Burgos
Although ulcerative colitis and Crohn's disease have traditionally been considered to be inflammatory diseases limited to the gastrointestinal tract, it has been shown that both pathologies are frequently accompanied by various extraintestinal disorders. There is an increasing evidence that they may also manifest in the nervous system, including the peripheral and the central parts. Although some of these neurological complications have been known for a long time, such as cerebrovascular disease, vasculitis and autoinmune processes including neuropathies and cerebral demyelination, others have been recently described...
May 10, 2008: Medicina Clínica
Silvio Antonio Namendys Silva, Juan Gabriel Posadas Calleja, Guillermo Domínguez Cherit
We report an autoinmune myocarditis case as a complication of celiac disease in a 28 year old woman. She had a 15 month history or diarrhea. She suffered pelvic trauma due to an episode of syncope and was admitted with refractory shock to fluid repletion. At laparotomy, two moderate hematomas were found in the subcutaneous space and retroperitoneum. Later she developed hemodynamic instability requiring positioning of a Swan-Ganz pulmonary artery catheter that demonstrated pattern of cardiogenic shock. Echocardiography demonstrated dilation of all four cavities and 35% ejection fraction...
January 2005: Revista de Gastroenterología de México
J A Gómez-Puerta, M Cucho Venegas, R Cervera Segura, J Font Franco
No abstract text is available yet for this article.
November 2003: Revista Clínica Española
C Garaizar
INTRODUCTION: The development of scientific advances, constantly opening new frontiers of knowledge, leads to increasing complexity and specialization. DEVELOPMENT: The conflict between the never ending medical specialization and the opposite tendency, which is based mostly on economic grounds, prevents the acquisition of new knowledge across different disorders and diseases. Considering the brain as a complex adaptative system, it follows that in order to understand its pathogenic mechanisms and to design new therapies, the study of the interrelation of all parts concerned must be undertaken...
August 1, 2002: Revista de Neurologia
J Font Franco, R Cervera Segura
No abstract text is available yet for this article.
November 2001: Revista Clínica Española
C A Rubio
In hematoxylin and eosin (H and E) stained sections from liver biopsies, the destruction of bile ducts in the portal triads is regarded as an important histologic parameter in the diagnosis of primary biliary cirrhosis (PBC). In contrast, the bile ducts are not destroyed by chronic inflammation in chronic active hepatitis (CAH). Nevertheless, the differential histologic diagnosis between PBC and virus or autoinmune-induced chronic active hepatitis (CAH), is very difficult in 15% of cases. That difficulty is mainly due to the impossibility of identifying bile ducts in the portal triads with marked lymphocytic infiltration...
March 1998: In Vivo
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