keyword
https://read.qxmd.com/read/38528459/positivity-rates-trends-and-experiences-of-health-workers-on-human-papillomavirus-screened-using-genexpert-in-uganda-a-three-year-retrospective-cohort-study
#1
JOURNAL ARTICLE
Harriet Nakigozi, Paul Mukama Ategyeka, Susan Nabadda, Rawlance Ndejjo
INTRODUCTION: Cervical cancer is a major public health issue in Uganda, with high incidence due to limited screening especially in rural areas. In 2019, HPV DNA testing using GeneXpert was rolled out to improve screening access. Assessing progress and challenges since its introduction is important. AIM: To determine genotype distribution and explore health worker experiences with HPV screening using GeneXpert in Uganda. METHODS: We conducted a retrospective cohort study where HPV screening data from 66 GeneXpert labs from March 2021-May 2023 country wide was analyzed...
March 25, 2024: BMC Cancer
https://read.qxmd.com/read/38471786/preliminary-results-from-retrospective-correlation-of-circulating-tumor-dna-ct-dna-with-imaging-for-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#2
JOURNAL ARTICLE
Amit Agarwal, Alok A Bhatt, Samip Patel, Girish Bathla, John Murray, Patricia Rhyner
The role of molecular markers is increasingly being recognized for head and neck tumors ranging from benign lesions like paragangliomas to malignancies like squamous cell carcinomas (SCCa). Multiple studies have recently validated blood tests for circulating tumor tissue modified viral- human papillomavirus DNA (HPV ct-DNA) ( NavDx, Naveris Laboratories ) for posttreatment surveillance of HPV-driven oropharyngeal SCCa. This technology quantifies fragments of circulating DNA that are shed into the blood stream with very high (>95%) positive and negative predictive values and are also highly sensitive in distinguishing tumor HPV-DNA from a non-cancerous source...
March 12, 2024: AJNR. American Journal of Neuroradiology
https://read.qxmd.com/read/38441194/molecular-and-nutritional-markers-in-head-and-neck-cancer
#3
JOURNAL ARTICLE
Gerard Milano, Jocelyn Gal, René-Jean Bensadoun
PURPOSE OF REVIEW: There is still a need of biomarkers in the induction and neoadjuvant settings for squamous cell carcinoma of the head and neck (SCCHN). The objective of this concise review article is to give an overview on both predictive and prognostic biomarkers potentially useful for the management of SCCHN. RECENT FINDINGS: Human papilloma virus (HPV) positivity translated by the presence of the protein indicator p16 is synonymous of favorable prognosis SCCHN...
March 1, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38429823/prevalence-and-genotype-distribution-of-hpv-infections-among-women-in-chengdu-china
#4
JOURNAL ARTICLE
Junying Zhang, Tianzhi Zha, Xuemei Wang, Weijun He
BACKGROUND: Human papilloma virus (HPV) infection among female is the cause of cervical cancer and genital warts. In China, the HPV vaccination rate and the target population screening rate among females are low, and the aims of this study on the genotype distribution and prevalence of HPV infection were to provide more targeted strategies for the prevention and treatment of cervical cancer and HPV-related diseases. METHODS: Polymerase chain reaction-reverse dot blot (PCR-RDB) was adopted for HPV genotyping test, the prevalence and 23 genotypes distribution of HPV infections among 181,705 women in Chengdu from 2013 to 2020 were analysed...
March 1, 2024: Virology Journal
https://read.qxmd.com/read/38409276/multimodal-detection-of-molecular-residual-disease-in-high-risk-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#5
JOURNAL ARTICLE
Enrique Sanz-Garcia, Jinfeng Zou, Lisa Avery, Anna Spreafico, John Waldron, David Goldstein, Aaron Hansen, B C John Cho, John de Almeida, Andrew Hope, Ali Hosni, Ezra Hahn, Bayardo Perez-Ordonez, Zhen Zhao, Christopher Smith, Yangqiao Zheng, Nitthusha Singaravelan, Scott V Bratman, Lillian L Siu
Up to 30% of patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) relapse. Molecular residual disease (MRD) detection using multiple assays after definitive therapy has not been reported. In this study, we included patients with LA-HNSCC (stage III Human Papilloma virus (HPV)-positive, III-IVB HPV-negative) treated with curative intent. Plasma was collected pre-treatment, at 4-6 weeks (FU1) and 8-12 weeks (FU2) post-treatment. Circulating tumor DNA (ctDNA) was analyzed using a tumor-informed (RaDaR®) and a tumor-naïve (CAPP-seq) assay...
February 26, 2024: Cell Death and Differentiation
https://read.qxmd.com/read/38400188/genital-and-oral-hpv-geno-prevalence-measured-through-urine-and-saliva-samples-in-young-adults-in-italy
#6
JOURNAL ARTICLE
Francesco Napolitano, Silvia Angelillo, Aida Bianco, Gabriella Di Giuseppe, Valeria Di Onofrio, Francesca Licata, Giorgio Liguori, Carmelo Giuseppe Angelo Nobile, Maria Pavia, Concetta Paola Pelullo, Federica Zito Marino, Italo Francesco Angelillo
BACKGROUND: The aims of the study were to determine, in the urine and oral samples of young adults, the genotype-specific prevalence of Human Papilloma Virus (HPV) infection, the HPV DNA type-specific prevalence in unvaccinated and vaccinated individuals, and the determinants of HPV infection. METHODS: Selected participants were asked to fill in a self-administered questionnaire and to self-collect urine and saliva samples. RESULTS: Among the 1002 participants, 81 (8...
February 16, 2024: Vaccines
https://read.qxmd.com/read/38395851/a-population-based-study-on-human-papillomavirus-infection-and-associated-risk-factors-among-women-of-the-remote-south-andaman-island-india
#7
JOURNAL ARTICLE
Rehnuma Parvez, Paluru Vijayachari, Kannan Thiruvengadam, Avijit Roy, Mrinmoy Kumar Saha, Jawahar Ramasamy, Alwin Vins, Lipika Biswas, Alvencia Vaz, Harpreet Kaur, Muruganandam Nagarajan
BACKGROUND: Human papillomavirus (HPV) is associated with cervical cancer and cervical dysplasia worldwide. Data on HPV prevalence in a region is important because it serves as a predictor of the likelihood of the population in that particular region acquiring cervical cancer. Moreover, with the availability of effective vaccines, the public health system must be aware of the preponderance of HPV to implement the vaccine. The present study was designed to understand the prevalence of HPV and associated factors among the women of South Andaman Island...
February 23, 2024: BMC Women's Health
https://read.qxmd.com/read/38383366/prevalence-of-genital-high-risk-human-papillomavirus-infections-and-associated-factors-among-women-living-with-human-immunodeficiency-virus-in-uganda
#8
JOURNAL ARTICLE
Harriet Nakigozi, Rawlance Ndejjo, William Bazeyo, Annet Nabaggala, Caroline Achola, Moses Iga, Simeon Kalyesubula, Ben Kanamwangi, Gerald Mutungi, Charles Batte, David Mukunya, Lawrence Sserwanga, Godfrey Gemageine, Charles Akiya Oyoo, Susan Nabadda
BACKGROUND: Women living with HIV are at risk for cervical dysplasia and cancer worldwide. In 2015, the World Health Organization (WHO) recommended that testing for high-risk HPV (hrHPV) infection be incorporated into cervical cancer screening programs using molecular nucleic acid tests (NATs) but this has not previously been done in Uganda. The country's coverage for Human Papilloma Virus (HPV) screening remains low at less than 10% for women aged 25-49 years. This study determined the genital prevalence of hrHPV infection and the associated factors among women living with HIV in Uganda...
February 21, 2024: BMC Cancer
https://read.qxmd.com/read/38255725/the-role-of-human-papilloma-virus-hpv-in-primary-lung-cancer-development-state-of-the-art-and-future-perspectives
#9
REVIEW
Dania Nachira, Maria Teresa Congedo, Ettore D'Argento, Elisa Meacci, Jessica Evangelista, Carolina Sassorossi, Giuseppe Calabrese, Adriana Nocera, Khrystyna Kuzmych, Rosaria Santangelo, Guido Rindi, Stefano Margaritora
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Notably, the incidence of lung cancer among never-smokers, predominantly women, has been rising in recent years. Among the various implicated risk factors, human papilloma virus (HPV) may play a role in the development of NSCLC in a certain subset of patients. The prevalence of high-risk HPV-DNA within human neoplastic lung cells varies across the world; however, the carcinogenetic role of HPV in NSCLC has not been completely understood...
January 10, 2024: Life
https://read.qxmd.com/read/38241205/a-protide-of-azt-shows-activity-against-human-papillomaviruses
#10
JOURNAL ARTICLE
Tim Gniech, Adrian Humboldt, Kathy A Keith, Scott H James, Clemens Richert
Infection by human papillomaviruses (HPV) can cause warts and tumors. So far, no small molecule antiviral has been approved for the treatment of infections with this DNA virus, although preclinical studies show activity for nucleosidic compounds, such as 9-(2-phosphonylmethoxy)ethylguanine (PMEG) or cidofovir. This prompted us to test new prodrug versions of the nucleoside analog 3'-azido-2',3'-dideoxythymidine (AZT), known to be active against reverse transcriptases and approved for the treatment of HIV. Here we report the synthesis of an ethylbutyl alaninyl ester phosphosphoramidate prodrug of AZT, dubbed AZAEB, and its activity against HPV, a target not known to be sensitive to AZT...
January 19, 2024: ChemMedChem
https://read.qxmd.com/read/38196490/prevalence-of-human-papilloma-virus-in-potentially-malignant-oral-disorders-is-a-risk-factor-for-development-of-early-dysplasia-a-cytological-investigation
#11
JOURNAL ARTICLE
Maham Javed, Rabia Anjum, Gulraiz Zulifqar, Farhan Rasheed, Ali Amar, Nadia Naseem
OBJECTIVE: The proposed study was planned to screen Human Papilloma Virus (HPV) status in potentially malignant oral disorders (PMOD) and correlated HPV positivity with cytological changes in oral smears. METHODS: This descriptive cross-sectional study was conducted at University of Health Sciences Lahore, Pakistan from April 2020 to April 2021. Oral smears from N=162 patients with PMODs were taken by the Cytobrush and Manual Liquid Based Cytology was performed followed by p16 antibody detection on immunohistochemistry and HPV-DNA detection by conventional polymerase chain reaction (PCR)...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38186411/laryngectomy-in-young-patients-a-case-series-and-review-of-the-literature
#12
JOURNAL ARTICLE
Leyla Ozbek, Ankit Patel, Jonathan Hughes
Background and objective The peak incidence of laryngeal cancer is seen in individuals aged over 65 years, with very few patients under 50 years developing advanced laryngeal cancer necessitating laryngectomy. Apart from often delayed diagnosis, this younger cohort faces a unique set of challenges related to fertility preservation, lower recruitment to clinical trials, and significant psychological impact. In light of this, this case series aimed to examine the various characteristics of patients below the age of 50 years undergoing total laryngectomy...
December 2023: Curēus
https://read.qxmd.com/read/38173455/a-case-of-condyloma-acuminatum-of-the-bladder-concurrently-diagnosed-with-urothelial-carcinoma
#13
Ibuki Tsuru, Masaki Nakamura, Taro Izumi, Akihiro Ono, Sakiko Miura, Teppei Morikawa, Kazuyoshi Shigehara, Tadaichi Kitamura, Haruki Kume, Yoshiyuki Shiga
INTRODUCTION: Condyloma acuminatum usually occurs in the external genitalia and rarely in the bladder mucosa. Here, we report a case of condyloma acuminatum of the bladder that was detected concurrently with urothelial carcinoma. CASE PRESENTATION: A 42-year-old man was referred to our urology department with positive urine cytology for urothelial carcinoma. Cystoscopy revealed a broad-base nonpapillary bladder tumor. The patient underwent a transurethral resection of the bladder tumor...
January 2024: IJU case reports
https://read.qxmd.com/read/38158930/self-sampling-for-human-papilloma-virus-dna-as-a-strategy-to-increase-access-to-cervical-cancer-screening-patients-and-providers-perspectives-on-facilitators-and-barriers-to-scale
#14
JOURNAL ARTICLE
Eva Lathrop, Marcos Chissano, Guilhermina Tevir, Yolanda Chongo, Elvira Cambe, Edson Chivambo, Hannah Hoover, Paul Bouanchaud
Self-sampling represents a high accuracy approach to human papilloma virus DNA (HPV-DNA) testing that allows for privacy and autonomy. As part of a larger study to evaluate cervical cancer screening in Mozambique, we explored user-driven facilitators and barriers to, and provider perspectives on, self-sampling. Our study was conducted in 4 public health facilities in 2 districts in Mozambique. Women aged 30-49 were prospectively enrolled for HPV screening and were offered provider or self-collected sampling...
December 31, 2023: African Journal of Reproductive Health
https://read.qxmd.com/read/38156851/novel-complex-of-zinc-ii-dichloroethylenediamine-synthesis-characterization-in-silico-and-in-vitro-evaluation-against-cervical-cancer-cells
#15
JOURNAL ARTICLE
Indah Raya, Desy Kartina, Ronald Ivan Wijaya, Rizal Irfandi, Eid A Abdalrazaq, Prihantono Prihantono, Santi Santi, Eka Pratiwi, Andi Besse Khaerunnisa, Dewi Luthfiana, Bulkis Musa, Hasnah Natsir, Maming Maming, Zaraswati Dwyana Zainuddin, Ramlawati Ramlawati, Ahmad Fudholi, Andi Nilawati Usman, Unang Supratman, Maulida Mazaya, Sandi Sufiandi
OBJECTIVE: Cervical cancer is a malignancy originating from the cervix and often caused by oncogenic Human Papilloma Virus (HPV), specifically subtypes 16 and 18. Anticancer drugs are chemotherapeutic compounds used for cancer treatment. Therefore, this research aims to synthesize and characterize Zinc (II) dichloroethylenediamine (Zn(en)Cl2) complex, as well as determine its antiproliferative activity against HeLa cells. The Zn(en)Cl2 complex was successfully synthesized, and the antiproliferative activity was tested...
December 1, 2023: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38156842/relevance-of-partial-p16-immunostaining-in-oral-squamous-cell-carcinoma-and-co-relation-with-hpv-dna-status
#16
JOURNAL ARTICLE
Farhat Naz, Nadeem Tanveer, Hitesh Verma, Kumar Arava Sudheer, Aanchal Kakkar, Amar Ranjan, Anita Chopra, Pranay Tanwar
INTRODUCTION: Immunostaining criteria for p16 positivity in oropharyngeal squamous cell carcinoma have been laid down by College of American Pathologists (CAP) and the American Society of Clinical Oncology (ASCO). The staining should be of moderate to strong intensity seen in 70 percent of the tumor cells. Recent studies have pointed out that a small minority of cases are missed using p16 as the surrogate marker at above mentioned cut off. By convention the same criteria have been used for oral squamous cell carcinoma...
December 1, 2023: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/38101135/circulating-tumor-hpv-dna-assessments-after-surgery-for-human-papilloma-virus-associated-oropharynx-carcinoma
#17
JOURNAL ARTICLE
Spenser S Souza, Erika M Stephens, Alexandra T Bourdillon, Rohith Bhethanabotla, Zainab Farzal, Karolina Plonowska-Hirshfeld, Jesse R Qualliotine, Chase M Heaton, Patrick K Ha, William R Ryan
PURPOSE: To understand the utility of circulating tumor human papillomavirus DNA (ctHPVDNA) blood testing for HPV-associated oropharynx squamous cell carcinoma (HPV + OPSCC) after definitive surgery. MATERIALS AND METHODS: Prospective cohort study of HPV(+)OPSCC patients with ctHPVDNA test data to assess its accuracy in detecting biopsy-confirmed disease at various post-treatment time points. Eligible patients had p16(+)/HPV(+) OPSCC and ctHPVDNA testing performed at any time pre-operatively and/or postoperatively...
December 9, 2023: American Journal of Otolaryngology
https://read.qxmd.com/read/38043336/detection-of-high-risk-hpv-16-genotypes-in-cervical-cancers-using-isothermal-dna-amplification-with-electrochemical-genosensor
#18
JOURNAL ARTICLE
Panisara Nakowong, Patutong Chatchawal, Thanyarat Chaibun, Nimaradee Boonapatcharoen, Chamras Promptmas, Waranun Buajeeb, Su Yin Lee, Patcharee Jearanaikoon, Benchaporn Lertanantawong
Cervical cancer emerges as the third most prevalent types of malignancy among women on a global scale. Cervical cancer is significantly associated with the persistent infection of human papillomavirus (HPV) type 16. The process of diagnosing is crucial in order to prevent the progression of a condition into a malignant state. The early detection of cervical cancer through initial stage screening is of the utmost significance in both the prevention and effective management of this disease. The present detection methodology is dependent on quantitative polymerase chain reaction (qPCR), which necessitates the use of a costly heat cycler instrument...
November 28, 2023: Talanta
https://read.qxmd.com/read/38022045/a-comprehensive-review-of-treatment-approaches-for-cutaneous-and-genital-warts
#19
REVIEW
Vaibhav B Kore, Ashish Anjankar
Cutaneous and genital warts are common in both developed as well as developing countries. Human papillomavirus (HPV), which is a double-stranded DNA virus, is the causative agent of wart infection. Different types of HPV viruses are responsible for the different severity of diseases. Some types are associated with malignancy of the anal region and cervix. HPV is a common sexually transmitted disease in the United States. The incidence is most common in the younger age groups and the elderly population...
October 2023: Curēus
https://read.qxmd.com/read/37972346/clinical-validation-of-human-papilloma-virus-circulating-tumor-dna-for-early-detection-of-residual-disease-after-chemoradiation-in-cervical-cancer
#20
MULTICENTER STUDY
Kathy Han, Jinfeng Zou, Zhen Zhao, Zeynep Baskurt, Yangqiao Zheng, Elizabeth Barnes, Jennifer Croke, Sarah E Ferguson, Anthony Fyles, Lilian Gien, Adam Gladwish, Magali Lecavalier-Barsoum, Stephanie Lheureux, Jelena Lukovic, Helen Mackay, Eve-Lyne Marchand, Ur Metser, Michael Milosevic, Amandeep S Taggar, Scott V Bratman, Eric Leung
PURPOSE: Most cervical cancers are caused by human papilloma virus (HPV), and HPV circulating tumor DNA (ctDNA) may identify patients at highest risk of relapse. Our pilot study using digital polymerase chain reaction (dPCR) showed that detectable HPV ctDNA at the end of chemoradiation (CRT) is associated with inferior progression-free survival (PFS) and that a next-generation sequencing approach (HPV-seq) may outperform dPCR. We aimed to prospectively validate HPV ctDNA as a tool for early detection of residual disease...
February 1, 2024: Journal of Clinical Oncology
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