keyword
MENU ▼
Read by QxMD icon Read
search

human papilloma virus DNA

keyword
https://www.readbyqxmd.com/read/27902986/the-presence-of-hpv-dna-in-neck-lymph-node-metastasis-correlates-with-improved-overall-survival-of-patients-with-oropharyngeal-cancer-undergoing-surgical-treatment
#1
Eiji Shimura, Takanori Hama, Toshihito Suda, Masahiro Ikegami, Mitsuyoshi Urashima, Hiromi Kojima
BACKGROUND: Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established. METHODS: A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated...
December 1, 2016: Oncology
https://www.readbyqxmd.com/read/27900000/involvement-of-tp53-and-tp16-expression-in-human-papillomavirus-associated-non-small-cell-lung-cancer
#2
Ming Li, Xiao-Lei Zhang, Fang Deng, Li-Ting Qian, Shui-Ping Meng, Wu-Lin Shan, Bao-Long Wang
Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 and TP16 expression in Chinese patients with advanced NSCLC. HPV DNA was detected in 20 out of 83 (24%) lung tumors, and was observed more frequently in non-smokers, patients with lymph node metastasis, and patients with poorly differentiated tumors (P=0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27891400/prevalence-of-human-papilloma-virus-infection-in-young-primiparous-women-during-postpartum-period-study-from-a-tertiary-care-center-in-northern-india
#3
Alpana Garg, Vanita Suri, Raje Nijhawan, Neelam Aggarwal, Ritu Aggarwal, Charu Guleria, Mili Thakur
INTRODUCTION: Assessment of high-risk Human Papilloma Virus (HPV) prevalence is important for monitoring long-term decrease in cervical cancer after implementation of the prophylactic HPV vaccination. AIM: To determine the prevalence of high-risk HPV infection and cytological abnormalities in young primiparous women in the age group of 16-26years. MATERIALS AND METHODS: In this cross-sectional study, 214 primiparous women aged 16-26years were recruited from a public tertiary health care center postpartum clinic between June 2013 and May 2014...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27884161/hpv16-integration-probably-contributes-to-cervical-oncogenesis-through-interrupting-tumor-suppressor-genes-and-inducing-chromosome-instability
#4
Jun-Wei Zhao, Fang Fang, Yi Guo, Tai-Lin Zhu, Yun-Yun Yu, Fan-Fei Kong, Ling-Fei Han, Dong-Sheng Chen, Fang Li
BACKGROUND: The integration of human papilloma virus (HPV) into host genome is one of the critical steps that lead to the progression of precancerous lesion into cancer. However, the mechanisms and consequences of such integration events are poorly understood. This study aims to explore those questions by studying high risk HPV16 integration in women with cervical intraepithelial neoplasia (CIN) and cervical squamous cell carcinoma (SCC). METHODS: Specifically, HPV integration status of 13 HPV16-infected patients were investigated by ligation-mediated PCR (DIPS-PCR) followed by DNA sequencing...
November 25, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27872524/human-papilloma-virus-in-oral-cavity-cancer-and-relation-to-change-in-quality-of-life-following-treatment-a-pilot-study-from-northern-india
#5
Abhishek Kumar Singh, Jitendra Kumar Kushwaha, Akshay Anand, Abhinav Arun Sonkar, Nuzhat Husain, Kirti Srivastava, Sudhir Singh
Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27867303/dna-methylation-of-cellular-retinoic-acid-binding-proteins-in-cervical-cancer
#6
Ana L Arellano-Ortiz, Mauricio Salcedo-Vargas, Claudia L Vargas-Requena, José A López-Díaz, Antonio De la Mora-Covarrubias, Juan C Silva-Espinoza, Florinda Jiménez-Vega
This study determined the methylation status of cellular retinoic acid-binding protein (CRABP) gene promoters and associated them with demographic characteristics, habits, and the presence of human papilloma virus (HPV) in patients with cervical cancer (CC), low and high squamous intraepithelial lesions, and no intraepithelial lesion. Women (n = 158) were selected from the Colposcopy Clinic of Sanitary Jurisdiction II in Ciudad Juarez, Chihuahua, Mexico. Demographic characteristics and habit information were collected...
2016: Genetics & Epigenetics
https://www.readbyqxmd.com/read/27819735/hpv-genotype-analysis-for-women-in-shaanxi-province-of-china
#7
J Li, Y Y Wang, X F Tian, X Nan, T Yan, P Wang, Y L Fu, G Q Wang
The aim of this study was to examine the subtype distribution of human papilloma virus (HPV) in women in the Shaanxi Province of China. A DNA chip, along with polymerase chain reaction amplification and reverse dot blot technology, was adopted to analyze the HPV genotypes of 22,937 cases of cervical cell specimens. The HPV infection rate was 18.70%, wherein high-risk, low-risk, and high- and low-risk multiple infection rates were 15.75, 2.96 and 1.91%, respectively. High-risk infections accounted for 84.20% of total infections...
November 3, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27806556/hpv-and-the-development-of-colorectal-cancer
#8
Mohamad Nidal Khabaz
Over the past two decades, many studies reported that around (20%) of the worldwide malignant tumors problem can be related to viral infections. Some publications recently have described a relationship between malignant colorectal tumors and human papilloma virus (HPV), but these findings are still debatable. The purpose of this report is to evaluate the existence of the genetic sequences and the proteins of HPV in the transformed cells of colorectal cancer in Saudi Arabia. Extracted DNA from eighty three archival colorectal tumor samples were examined for HPV DNA types 16 and 18 and their protein products using polymerase chain reaction (PCR) technique in addition to immunohistochemical staining...
August 26, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27797244/lack-of-evidence-for-a-relationship-between-high-risk-human-papillomaviruses-and-breast-cancer-in-iranian-patients
#9
Masoud Doosti, Mehran Bakhshesh, Shokouh Taghipour Zahir, Mohammad Shayestehpour, Mojgan Karimi-Zarchi
BACKGROUND: Whether there is any relationship between human papilloma virus (HPV) and breast carcinoma is not clear. Some previous studies have indicated a possible role in oncogenesis in the breast. In this study, we therefore analyzed the presence of HPV infection in breast tissues of Iranian women from Yazd city. MATERIALS AND METHODS: In a cross-sectional study, formalin-fixed paraffin-embedded tissues from 87 patients with breast cancer and 84 cases with breast fibrocystic lesions (control group) were selected from a tissue archive...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27771518/the-effect-of-methylenetetrahydrofolate-reductase-polymorphisms-on-susceptibility-to-human-papilloma-virus-infection-and-cervical-cancer
#10
Mogge Hajiesmaeil, Farzaneh Tafvizi, Soheila Sarmadi
Cervical cancer is the third most common cancer among women worldwide. Several factors lead to cervical cancer, among which human papilloma virus (HPV) infection has a prominent role. Methylenetetrahydrofolate reductase (MTHFR) is crucial in folate metabolic pathway and plays an important role in DNA synthesis and DNA methylation. MTHFR gene polymorphisms, including C677T and A1298C, lead to reduced enzyme activity. This case-control study aims to illustrate the association between MTHFR gene polymorphisms and the risk of cervical cancer...
December 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27765330/low-prevalence-of-transcriptionally-active-human-papilloma-virus-in-indian-patients-with-hnscc-and-leukoplakia
#11
Priyanka G Bhosale, Manishkumar Pandey, Rajiv S Desai, Asawari Patil, Shubhada Kane, Kumar Prabhash, Manoj B Mahimkar
OBJECTIVES: In the present study, we comprehensively analyzed the prevalence of transcriptionally active human papilloma virus (HPV) in tissue samples of Indian patients with leukoplakia, predominantly hyperplastic lesions and head and neck squamous cell carcinoma (HNSCC). In addition, saliva samples from patients with HNSCC were screened for HPV detection. STUDY DESIGN: P16 overexpression was analyzed by immunohistochemistry. Tissue samples of leukoplakia (n = 121) and HNSCC (n = 427) and saliva from patients with HNSCC (n = 215) were tested for HPV using nested polymerase chain reaction...
November 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27732948/impact-of-hpv-infection-on-oral-squamous-cell-carcinoma
#12
Carolin Götz, Enken Drecoll, Melanie Straub, Oliver Bissinger, Klaus-Dietrich Wolff, Andreas Kolk
BACKGROUND: Head and neck squamous cell carcinomas (HNSCC) are often divided by their aetiology. Noxae associated collectives are compared with the human papilloma virus (HPV)-associated group, whereas different localisations of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas are mostly discussed as one single group. Our aim was to show that classification by aetiology is not appropriate for OSCC. RESULTS: HPV DNA was detected by PCR in 7 (3.47%) patients, and we identified 12 (5...
October 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27699543/predictive-factors-for-outcome-and-quality-of-life-in-hpv-positive-and-hpv-negative-hnscc
#13
Jochen Hess
Infection with high-risk types of the human papilloma virus (HPV) is an etiological risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and associated with a better response to therapy and improved survival. A better understanding of the molecular principles underlying the differences in clinical behavior could pave the way to establish more effective and less toxic therapy for HPV-positive OPSCC and their HPV-negative counterparts. Compelling experimental evidence demonstrates that extensive global reprogramming of epigenetic profiles is as important as genetic mutations during neoplastic transformation and malignant progression, including HPV-positive OPSCC...
2017: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27699530/risk-factors-for-oral-infection-with-human-papillomavirus
#14
Pawel Golusinski
Human papillomavirus has been identified as a causative factor for a subset of head and neck carcinomas (HNSCC). The majority of the HPV-positive tumors arises in the oropharyngeal region, and at present, the infection of the human papilloma type 16 is the major cause of the oropharyngeal cancer development. Patients with HPV DNA-positive tumors have been shown to be younger in age and are less likely to have a history of tobacco smoking or alcohol use. The tumors referred to the HPV positivity have been proven to more likely confer better prognosis...
2017: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27699512/synergistic-effect-of-programmed-cell-death-protein%C3%A2-1-blockade-and-secondary-lymphoid-tissue-chemokine-in-the-induction-of-anti-tumor-immunity-by-a-therapeutic-cancer-vaccine
#15
Soheila Moeini, Mohsen Saeidi, Fatemeh Fotouhi, Mahdieh Mondanizadeh, Sadegh Shirian, Alireza Mohebi, Ali Gorji, Amir Ghaemi
The use of DNA vaccines has become an attractive approach for generating antigen-specific cytotoxic CD8(+) T lymphocytes (CTLs), which can mediate protective antitumor immunity. The potency of DNA vaccines encoding weakly immunogenic tumor-associated antigens (TAAs) can be improved by using an adjuvant injected together with checkpoint antibodies. In the current study, we evaluated whether the therapeutic effects of a DNA vaccine encoding human papilloma virus type 16 (HPV-16) E7 can be enhanced by combined application of an immune checkpoint blockade directed against the programmed death-1 (PD-1) pathway and secondary lymphoid tissue chemokine (SLC) also known as CCL21 adjuvant, in a mouse cervical cancer model...
October 3, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27664839/prime-boost-therapeutic-vaccination-in-mice-with-dna-dna-or-dna-fowlpox-virus-recombinants-expressing-the-human-papilloma-virus-type-16-e6-and-e7-mutated-proteins-fused-to-the-coat-protein-of-potato-virus-x
#16
Elena Illiano, Massimiliano Bissa, Francesca Paolini, Carlo Zanotto, Carlo De Giuli Morghen, Rosella Franconi, Antonia Radaelli, Aldo Venuti
The therapeutic antitumor potency of a prime-boost vaccination strategy was explored, based on the mutated, nontransforming forms of the E6 (E6F47R) and E7 (E7GGG) oncogenes of Human Papilloma Virus type 16 (HPV16), fused to the Potato virus X (PVX) coat protein (CP) sequence. Previous data showed that CP fusion improves the immunogenicity of tumor-associated antigens and may thus increase their efficacy. After verifying the correct expression of E6F47RCP and E7GGGCP inserted into DNA and Fowlpox virus recombinants by Western blotting and immunofluorescence, their combined use was evaluated for therapy in a pre-clinical mouse model of HPV16-related tumorigenicity...
October 2, 2016: Virus Research
https://www.readbyqxmd.com/read/27659129/rare-subtype-s-and-frequency-of-multi-viral-subtype-high-risk-human-papilloma-virus-infection-in-high-grade-squamous-intraepithelial-lesion-and-squamous-cell-carcinoma-in-a-cervical-carcinoma-prevalent-developing-country-a-multiplex-real-time-polymerase-chain
#17
Shabnam Akhter, Pradip Manna, Mohammed Kamal, C James Sung, W Dwayne Lawrence, M Ruhul Quddus
BACKGROUND: Bangladesh, with a population of 160 million and nearly half being women, has the 4th highest rate of cervical carcinoma deaths in the world. It is projected that ∼500,000 of these women would die of this entirely preventable cancer by 2030. HPV vaccination is not widely offered in Bangladesh. This pilot study is designed to find out the prevalence of rare and multi-viral high-risk HPV (hrHPV) subtype(s) infection which may help strategize a large scale vaccination program in tackling cervical carcinoma in the country...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27651159/genotypic-distribution-of-single-nucleotide-polymorphisms-in-oral-cancer-global-scene
#18
Shaleen Multani, Dhananjaya Saranath
Globocan 2012 reports the global oral cancer incidence of 300,373 new oral cancer cases annually, contributing to 2.1 % of the world cancer burden. The major well-established risk factors for oral cancer include tobacco, betel/areca nut, alcohol and high-risk oncogenic human papilloma virus (HPV) 16/18. However, only 5-10 % of individuals with high-risk lifestyle develop oral cancer. Thus, genomic variants in individuals represented as single nucleotide polymorphisms (SNPs) influence susceptibility to oral cancer...
September 20, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27649651/human-papilloma-virus-infection-and-cervical-cytomorphological-changing-among-intrauterine-contraception-users
#19
A Frega, F Manzara, M Schimberni, A Guarino, A Catalano, P Bianchi, R Marziani, G Cozza, G N Milazzo, D French, D Caserta
OBJECTIVE: The increased use of the intrauterine contraception (IUC) in female population and its probable relationship with cervical squamous intraepithelial lesions and cervical cancer make necessary clarify the possible interaction between the device and the pre-neoplastic lesions. PATIENTS AND METHODS: Seven hundred and eighty-nine patients users of IUC and 1491 patients ever users of IUC were followed every 6 months for 3 years. Each clinical control included Papanicolau test, colposcopy, HPV-DNA test and HPV-mRNA test...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27644644/frequency-and-type-distribution-of-human-papilloma-virus-in-patients-with-prostate-cancer-kerman-southeast-of-iran
#20
Fatemeh Atashafrooz, Farokh Rokhbakhsh-Zamin
Prostatic cancer is the second cause of cancer-related death among men worldwide. The human papilloma viruses (HPVs) are a family of sexually transmitted viruses which have may have roles in the etiology of inflammation in the prostate leading to benign prostatic hyperplasia (BPH) and prostate cancer (PCa). In this study, we evaluated the frequency of different HPV types in prostatic cancer and benign prostatic hyperplasia (BPH) in Kerman province, southeast of Iran, using real-time PCR techniques. The aim of the present research was to clarify any association with prostatic carcinogenesis...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
keyword
keyword
110741
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"