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https://www.readbyqxmd.com/read/28655092/-evaluation-of-clinical-characteristics-myd88-l265p-mutation-cxcr4-whim-mutation-and-prognosis-in-waldenstr%C3%A3-m-macroglobulinemia-a-single-center-retrospective-study-of-93-patients
#1
X X Cao, Q Meng, H Cai, Y Y Mao, M H Duan, T N Zhu, W Zhang, B Han, J L Zhuang, H C Cai, M Chen, J Feng, X Han, Y Zhang, C Yang, L Zhang, D B Zhou, J Li
Objective: To evaluate the clinical characteristics, MYD88(L265P) mutation, CXCR4(W)HIM mutation and prognosis in patients with Waldenström macroglobulinemia (WM). Methods: The clinical characteristics, International Prognostic Scoring System for symptomatic WM (WPSS) , and overall survival (OS) were retrospectively assayed in 93 patients with newly diagnosed WM at Peking Union Medical College Hospital during January 2000 to August 2016. The MYD88(L265P) mutation and CXCR4(W)HIM mutation were tested among 34 patients...
June 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28654863/stat6-promotes-intestinal-tumorigenesis-in-a-mouse-model-of-adenomatous-polyposis-by-expansion-of-mdscs-and-inhibition-of-cytotoxic-cd8-response
#2
Asha Jayakumar, Alfred L M Bothwell
Intestinal tumorigenesis in the ApcMin/+ model is initiated by aberrant activation of Wnt pathway. Increased IL-4 expression in human colorectal cancer tissue and growth of colon cancer cell lines implied that IL-4-induced Stat6-mediated tumorigenic signaling likely contributes to intestinal tumor progression in ApcMin/+ mice. Stat6 also appears to promote expansion of myeloid-derived suppressor cells (MDSCs) cells. MDSCs promote polyp formation in the ApcMin/+ model. Hence, Stat6 could have a broad role in coordinating both polyp cell proliferation and MDSC expansion...
June 24, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28654425/association-between-gene-polymorphisms-and-clinical-features-in-idiopathic-thrombocytopenic-purpura-patients
#3
Hadi Rezaeeyan, Kaveh Jaseb, Arash Alghasi, Ali Amin Asnafi, Najmaldin Saki
: Immune thrombocytopenic purpura (ITP) is an autoimmune disease in which increased platelet destruction and thrombocytopenia are diagnostic features. In fact, the exact pathogenesis of this disease is still unknown, but genetic changes can be a potential factor in the development of ITP. In this study, the relationship between polymorphisms with platelet destruction has been studied, which leads to decreased platelet count. Relevant literature was identified by a PubMed search (2000-2016) of English language papers using the terms 'ITP', 'polymorphism,' and 'immune system'...
June 24, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28654046/hypoxic-preconditioning-of-marrow-derived-progenitor-cells-as-a-source-for-the-generation-of-mature-schwann-cells
#4
Yat-Ping Tsui, Alan Kwan-Long Mung, Ying-Shing Chan, Daisy Kwok-Yan Shum, Graham Ka-Hon Shea
This manuscript describes a means to enrich for neural progenitors from the marrow stromal cell (MSC) population and thereafter to direct them to the mature Schwann cell fate. We subjected rat and human MSCs to transient hypoxic conditions (1% oxygen for 16 h) followed by expansion as neurospheres upon low-attachment substratum with epidermal growth factor (EGF)/basic fibroblast growth factor (bFGF) supplementation. Neurospheres were seeded onto poly-D-lysine/laminin-coated tissue culture plastic and cultured in a gliogenic cocktail containing β-Heregulin, bFGF, and platelet-derived growth factor (PDGF) to generate Schwann cell-like cells (SCLCs)...
June 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653765/a-liquid-calcium-vitamin-d3-supplement-is-effective-prophylaxis-against-hypocalcemic-toxicity-during-apheresis-platelet-donation
#5
Robert Weinstein, Stefanie Haynes, Yong Zhao, Elda Hickson, Jeanne Linden, Patricia St Pierre, Paula Ducharme, Paula Sulmasy, Molly Graves, Jeffrey A Bailey, Linda Welch, Amie Simard, Michelle Vauthrin, Mindy Greene
Hypocalcemic toxicity, because of return of citrate anion to the donor, is the major toxicity of apheresis platelet donation. Oral calcium carbonate, given prophylactically at the start of donation, has shown limited ability to alleviate this toxicity. We examined whether repeated prophylactic doses of calcium carbonate, or of a liquid preparation containing calcium citrate, calcium phosphate, and vitamin D3 , would be more effective at preventing symptoms of hypocalcemic toxicity. Symptoms were reported by 48% of donors who received no prophylaxis and 60% of donors who received 1000 mg of oral calcium carbonate at the start of, and every 20 minutes during, donation (P = 0...
June 27, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28653480/eltrombopag-for-secondary-failure-of-platelet-recovery-post-allogeneic-hematopoietic-stem-cell-transplant-in-children
#6
Salah Ali, Adam Gassas, Melanie Kirby-Allen, Joerg Krueger, Muhammad Ali, Tal Schechter
Secondary failure of platelet engraftment occurs in 20% of patients undergoing allogeneic HSCT and is associated with poor outcome. Currently, there are no guidelines for treatment of late thrombocytopenia and platelet transfusion is the mainstay of treatment. Here, we describe the use of Eltrombopag to treat secondary failure of platelet recovery following HSCT in a child with severe aplastic anemia. Eltrombopag resulted in recovery of platelet count with no need for platelet transfusion support with no reported side effects...
June 27, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28653472/residual-risk-of-bacterial-contamination-of-platelets-six-years-of-experience-with-sterility-testing
#7
Sandra Ramirez-Arcos, Caesar DiFranco, Terri McIntyre, Mindy Goldman
BACKGROUND: Canadian Blood Services screens 100% of platelet concentrates (PCs) for bacterial contamination with the BacT/ALERT system. Quality-control sterility testing of 1% (≥10 units) of outdated PCs is performed monthly. Data from routine screening, quality-control testing, and septic reactions obtained from 2010 to 2016 are presented herein. STUDY DESIGN AND METHODS: In total, 601,988 buffy coat PC pools and 186,737 apheresis PCs were routinely screened with aerobic cultures over 6 years...
June 26, 2017: Transfusion
https://www.readbyqxmd.com/read/28653425/storage-time-of-platelet-concentrates-and-all-cause-bacteremia-in-hematologic-patients
#8
Aukje L Kreuger, Rutger A Middelburg, Cock M C Bank, Erik A M Beckers, Adriaan J van Gammeren, Anja Leyte, Jan M M Rondeel, Karen M K de Vooght, Floor Weerkamp, Jaap Jan Zwaginga, Jean Louis H Kerkhoffs, Johanna G van der Bom
BACKGROUND: Extension of storage time of platelet (PLT) concentrates may result in an increased risk of bacteremia, directly via transfusion of contaminated products or indirectly via transfusion-related immunomodulation. We aimed to quantify the association of storage time of PLT concentrates and all-cause bacteremia in hematologic patients. STUDY DESIGN AND METHODS: We established a cohort of hematologic patients who received a PLT transfusion between 2005 and 2015...
June 26, 2017: Transfusion
https://www.readbyqxmd.com/read/28653184/reversal-of-the-platelet-inhibitory-effect-of-the-p2y12-inhibitors-clopidogrel-prasugrel-and-ticagrelor-in-vitro-a-new-approach-to-an-old-issue
#9
Lisa Schoener, Stefanie Jellinghaus, Bernhardt Richter, Christian Pfluecke, Georg Ende, Marian Christoph, Silvio Quick, Tobias Loehn, Uwe Speiser, David M Poitz, Johannes Mierke, Ruth H Strasser, Karim Ibrahim
AIM: Platelet transfusion is an effective option to reverse platelet inhibition in thienopyridine-treated patients suffering from bleedings or requiring urgent surgery. However, in ticagrelor-treated patients, the previous studies revealed significant clinical effects to platelet rich plasma (PRP) but poor response to pooled platelets (PP) as used in clinical routine. The aim of this study was to elucidate a potential pathomechanism to explain the poor response of ticagrelor to PP. METHODS AND RESULTS: From 79 whole blood samples of patients treated with ticagrelor, prasugrel, or clopidogrel, the PRI-VASP was determined before and after in vitro platelet supplementation of PP or PRP at increasing concentrations...
June 26, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28652948/streptococcus-mutans-a-potential-risk-factor-in-recurrent-hemorrhagic-stroke
#10
Tarek R Mansour, Yasaman Alam, Layth Dahbour, Ahmed Alnemari, Mouhammad Jumaa, Jason L Schroeder
Stroke is the fifth leading cause of death and is responsible for approximately nine percent of all deaths worldwide. Cases of Streptococcus mutans (S. mutans)-induced intracerebral hemorrhage as a result of bloodstream infections have seldom been reported. New reports show that bacteria with specific collagen binding proteins (CBPs), such as the Cnm type produced by S. mutans, may inhibit platelet aggregation and cause bleeding. In this article, we report on a 62-year-old man with a recent history of left frontal intracerebral hemorrhage (ICH) who presented to the emergency department after a fall due to suspected seizure while in rehabilitation...
May 19, 2017: Curēus
https://www.readbyqxmd.com/read/28652799/direct-oral-anticoagulants-in-patients-with-chronic-kidney-disease-patient-selection-and-special-considerations
#11
REVIEW
Jens Lutz, Kerstin Jurk, Helmut Schinzel
Many patients with chronic kidney disease (CKD) receive anticoagulation or antiplatelet therapy due to atrial fibrillation, coronary artery disease, thromboembolic disease, or peripheral artery disease. The treatment usually includes vitamin K antagonists (VKAs) and/or platelet aggregation inhibitors. The direct oral anticoagulants (DOAC) inhibiting factor Xa or thrombin represent an alternative for VKAs. In patients with acute and chronic kidney disease, caution is warranted, as DOACs can accumulate as they are partly eliminated by the kidneys...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28652743/zinc-oxide-nanoparticle-induced-atherosclerotic-alterations-in-vitro-and-in-vivo
#12
Zhen Yan, Wenjun Wang, Yongjun Wu, Wei Wang, Bing Li, Ning Liang, Weidong Wu
Engineered zinc oxide nanoparticles (ZnO-NPs) are currently being produced in high tonnage. Exposure to ZnO-NPs presents potential risks to cardiovascular system. Thus far, the toxicological effects of ZnO-NPs on cardiovascular system have not been well characterized. In this study, human coronary artery endothelial cells (HCAECs) were exposed to ZnO-NPs directly or indirectly using a transwell coculture system with human alveolar epithelial cell line A549 to mimic the lung/circulation interaction. It was shown that levels of proinflammatory mediators (interleukin-8 [IL-8] and tumor necrosis factor-α [TNF-α]) and biomarkers of atherosclerogenesis (heme oxygenase-1 [HO-1] and platelet endothelial cell adhesion molecules-1 [PECAM-1]) in the supernatants of culture media were significantly increased...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28652679/contrast-induced-thrombocytopenia-following-percutaneous-coronary-intervention
#13
Roberto Muniz Ferreira, João Mansur Filho, Paolo Blanco Villela, Juliano Carvalho Gomes de Almeida, Pedro Paulo Nogueres Sampaio, Felipe Neves de Albuquerque, Wolmar Pulcheri, Cláudio Buarque Benchimol
Contrast-induced thrombocytopenia is a rare complication distinguished by acute and severe platelet consumption, with spontaneous recovery within days. We describe a case of acute thrombocytopenia 6 hours after coronary angioplasty in a patient with a negative antiplatelet factor 4 test. The count reached 1 × 10(3)/µL, but improved spontaneously to 210 × 10(3)/µL after 8 days. In conclusion, physicians should be aware of this complication, particularly when dual antiplatelet therapy is being considered...
July 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28652403/protease-activated-receptor-4-and-p2y12-dimerize-co-internalize-and-activate-akt-signaling-via-endosomal-recruitment-of-%C3%AE-arrestin
#14
Thomas H Smith, Julia G Li, Michael R Dores, JoAnn Trejo
Vascular inflammation and thrombosis requires the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platelets and other cell types, protease-activated receptor-4 (PAR4) has been shown to dimerize with the purinergic receptor P2Y12 to coordinate β-arrestin-mediated Akt signaling, an important mediator of integrin activation. However, the mechanism by which the PAR4-P2Y12 dimer controls β-arrestin dependent Akt signaling is not known...
June 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28652214/elevated-levels-of-vwf-and-hmgb1-are-associated-with-disease-severity-and-clinical-outcome-of-scrub-typhus
#15
Hongliu Chen, Zong Ning, Ying Qiu, Yuanli Liao, Haihua Chang, Yuanyuan Ai, Yinghua Wei, Yiming Deng, Ying Shen
OBJECTIVE: This study aimed to investigate whether von Willebrand factor (vWF) and high mobility group box 1(HMGB1) were associated with severity and clinical outcome of scrub typhus and to seek novel biomarkers for surveillance and prognosis prediction of this infection. METHODS: Serum concentrations of vWF and HMGB1 were measured twice by enzyme linked immunosorbent assay (ELISA) for scrub typhus patients (n = 103), one prior to doxycycline therapy and the other at the 7th day of doxycycline therapy, and once for health controls (n = 32)...
June 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28651914/phenylsulfonylfuroxan-no-donor-phenols-synthesis-and-multifunctional-activities-evaluation
#16
Yundong Xie, Yaping Yang, Sen Li, Yanhong Xu, Wenfang Lu, Zizhang Chen, Guangde Yang, Yiping Li, Yongxiao Cao, Xiaoli Bian
Phenylsulfonyfuroxan nitric oxide (NO)-donor phenols were designed, synthesized and evaluated. The compounds were designed through a symbiotic approach using selected phenols and phenylsulfonylfuroxan NO-donor. The antioxidant activities of the hybrid compounds T2-T6 showed to be good in vivo. Compounds T4 and T6 revealed excellent yeast α-glucosidase inhibitory activity and anti-glycosylation activity. All of the compounds exhibited strong NO releasing activity and significant anti-platelet aggregation activity...
June 15, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28651806/von-willebrand-factor-deposition-and-adamts-13-consumption-in-allograft-tissue-of-thrombotic-microangiopathy-like-disorder-after-living-donor-liver-transplantation-a-case-report
#17
S Nakanuma, T Miyashita, H Hayashi, Y Ohbatake, H Takamura, M Okazaki, T Yamaguchi, S Sakai, I Makino, K Oyama, H Tajima, I Ninomiya, S Fushida, T Ohta
BACKGROUND: Thrombotic microangiopathy (TMA) pathogenesis after living donor liver transplantation (LDLT) is thought to be caused by release of unusually large von Willebrand factor multimers (UL-vWFMs) resulting from sinusoidal endothelial cell damage and induction of platelet adhesion and aggregation. A decrease in a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs-13 (ADAMTS-13) that cleave UL-vWFMs might cause excessive UL-vWFMs activity and result in platelet thrombus formation...
June 23, 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28651609/optimisation-of-a-double-centrifugation-method-for-preparation-of-canine-platelet-rich-plasma
#18
Hyeok-Soo Shin, Heung-Myong Woo, Byung-Jae Kang
BACKGROUND: Platelet-rich plasma (PRP) has been expected for regenerative medicine because of its growth factors. However, there is considerable variability in the recovery and yield of platelets and the concentration of growth factors in PRP preparations. The aim of this study was to identify optimal relative centrifugal force and spin time for the preparation of PRP from canine blood using a double-centrifugation tube method. METHODS: Whole blood samples were collected in citrate blood collection tubes from 12 healthy beagles...
June 26, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28651441/the-effect-of-ex-vivo-factor-xiii-supplementation-on-clot-formation-in-blood-samples-from-cardiac-and-scoliosis-surgery-patients
#19
Caroline Shams Hakimi, Malin S Carling, Emma C Hansson, Helena Brisby, Camilla Hesse, Vladimir Radulovic, Anders Jeppsson
Excessive perioperative bleeding remains a substantial problem. Factor XIII (FXIII) contributes to clot stability, and it has therefore been suggested that supplementation with FXIII concentrate may improve perioperative hemostasis. We evaluated the effects of increasing doses of FXIII, alone or in combination with fibrinogen or platelet concentrate, in blood samples from 2 considerably different groups of surgical patients: cardiac and scoliosis surgery patients. Whole-blood samples were collected immediately after operation from cardiac and scoliosis surgery patients...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28651419/-significance-of-evaluating-the-severity-of-patients-with-extremely-severe-burn-by-platelet-count-recovery-in-the-early-stage-post-burn
#20
Y Wu, Q Zhang, J Liu, J J Tang, J X Zheng, M Liu
Objective: To retrospectively analyze the prognostic value of platelet count recovery in the early stage post burn for patients with extremely severe burn, so as to evaluate their severity. Methods: A study involving 244 adult patients with extremely severe burn admitted to our hospital from January 2006 to December 2015, conforming to the inclusion criteria, was conducted. Data of their demography, injury, transmission, disease change in hospital, and platelet count from post injury day (PID) 1 to 10 were collected...
May 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
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