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https://www.readbyqxmd.com/read/28214180/a-successful-experience-of-the-iranian-blood-transfusion-organization-in-improving-accessibility-and-affordability-of-plasma-derived-medicine
#1
REVIEW
Azita Chegini, Seyed Ardeshir Torab, Ali Akbar Pourfatollah
Plasma is the liquid part of blood. It is estimated 21.6 million liters of plasma collect from Whole blood annually. From these plasma, 4.2 million liters transfuse, 8.1 million liters fractionate, 9.3 million liters waste. Nowadays, blood products and PDM (plasma derived medicine) consider as essential medicine in modern health care and transfusion medicine. Iranian blood transfusion organization as a non-profit organization was established in 1974 in order to centralize all blood transfusion activities from donor recruitment to distribution of blood components to hospitals...
January 4, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28213742/comparison-of-systemic-inflammatory-and-nutritional-scores-in-colorectal-cancer-patients-who-underwent-potentially-curative-resection
#2
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
BACKGROUND: Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection. METHOD: We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival...
February 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28213379/slowed-decay-of-mrnas-enhances-platelet-specific-translation
#3
Eric W Mills, Rachel Green, Nicholas T Ingolia
Platelets are anucleate cytoplasmic fragments that lack genomic DNA, but continue to synthesize protein using a pool of mRNAs, ribosomes, and regulatory small RNAs inherited from the precursor megakaryocyte (MK). The regulatory processes that shape the platelet transcriptome and the full scope of platelet translation have remained elusive. Using RNA-Seq and ribosome profiling of primary human platelets, we show the platelet transcriptome encompasses a subset of transcripts detected by RNA-Seq analysis of in vitro derived MK cells and these platelet-enriched transcripts are broadly occupied by ribosomes...
February 17, 2017: Blood
https://www.readbyqxmd.com/read/28213102/comparison-of-multiplate-and-verifynow-platelet-function-tests-in-predicting-clinical-outcome-in-patients-with-acute-coronary-syndromes
#4
Peter D Larsen, Ana S Holley, Alexander Sasse, Ali Al-Sinan, Sarah Fairley, Scott A Harding
INTRODUCTION: This study examined the ability of two widely used "point of care" platelet function assays, VerifyNow and Multiplate, to predict adverse outcomes in patients with acute coronary syndromes (ACS). METHODS: We examined platelet reactivity using VerifyNow and Multiplate P2Y12 assays in patients with ACS and the relationship between platelet reactivity and both MACE (defined as a composite of death, myocardial infarction, stroke, stent thrombosis and unplanned revascularisation) and TIMI major bleeding at 1year...
February 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28212919/thrombus-composition-in-sudden-cardiac-death-from-acute-myocardial-infarction
#5
Johanne Silvain, Jean-Philippe Collet, Paul Guedeney, Olivier Varenne, Chandrasekaran Nagaswami, Carole Maupain, Jean-Philippe Empana, Chantal Boulanger, Muriel Tafflet, Stephane Manzo-Silberman, Mathieu Kerneis, Delphine Brugier, Nicolas Vignolles, John W Weisel, Xavier Jouven, Gilles Montalescot, Christian Spaulding
BACKGROUND AND AIM: It was hypothesized that the pattern of coronary occlusion (thrombus composition) might contribute to the onset of ventricular arrhythmia and sudden cardiac death (SCD) in myocardial infarction (MI). METHODS: The TIDE (thrombus and inflammation in sudden death) study included patients with angiographically-proven acute coronary occlusion as the cause of a ST elevation MI (STEMI) complicated by Sudden Cardiac Death (SCD group) or not (STEMI group)...
February 14, 2017: Resuscitation
https://www.readbyqxmd.com/read/28212891/sulforaphane-inhibits-platelet-derived-growth-factor-induced-vascular-smooth-muscle-cell-proliferation-by-targeting-mtor-p70s6kinase-signaling-independent-of-nrf2-activation
#6
Noha M Shawky, Lakshman Segar
Activation of nuclear factor erythroid 2-related factor 2 (Nrf2, a transcription factor) and/or inhibition of mammalian target of rapamycin (mTOR) are implicated in the suppression of vascular smooth muscle cell (VSMC) proliferation. The present study has examined the likely regulatory effects of sulforaphane (SFN, an antioxidant) on Nrf2 activation and platelet-derived growth factor (PDGF)-induced mTOR signaling in VSMCs. Using human aortic VSMCs, nuclear extraction and siRNA-mediated downregulation studies were performed to determine the role of Nrf2 on SFN regulation of PDGF-induced proliferative signaling...
February 14, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28212842/pathophysiological-consequences-of-receptor-mistraffic-tales-from-the-platelet-p2y12-receptor
#7
Margaret R Cunningham, Riyaad Aungraheeta, Stuart J Mundell
Genetic variations in G protein-coupled receptor (GPCR) genes can disrupt receptor function in a wide variety of human genetic diseases, including platelet bleeding disorders. Platelets are critical for haemostasis with inappropriate platelet activation leading to the development of arterial thrombosis, which can result in heart attack and stroke whilst decreased platelet activity is associated with an increased risk of bleeding. GPCRs expressed on the surface of platelets play key roles in regulating platelet activity and therefore function...
February 14, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28212582/the-association-of-pretreatment-thrombocytosis-with-prognosis-and-clinicopathological-significance-in-cervical-cancer-a-systematic-review-and-meta-analysis
#8
Juan Cheng, Zhi Zeng, Qingjian Ye, Yu Zhang, Ronghua Yan, Changyan Liang, Jia Wang, Mengxiong Li, Mixuan Yi
Previous studies reported inconsistent findings about the relationship between pretreatment thrombocytosis and survival in patients with cervical cancer. This study aimed to evaluate the prognostic significance of thrombocytosis in cervical cancer. We searched databases to identify relevant articles. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Fourteen studies including 3,394 patients were eligible for the meta-analysis. Overall, an elevated platelet count was significantly associated with inferior overall survival (OS, hazard ratio [HR]: 1...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212553/the-clinical-use-of-the-platelet-lymphocyte-ratio-and-lymphocyte-monocyte-ratio-as-prognostic-predictors-in-colorectal-cancer-a-meta-analysis
#9
Ya-Huan Guo, Hai-Feng Sun, Yan-Bing Zhang, Zi-Jun Liao, Lei Zhao, Jie Cui, Tao Wu, Jian-Rong Lu, Ke-Jun Nan, Shu-Hong Wang
BACKGROUND: Conflicting evidence exists regarding the effects of platelet/lymphocyte ratio (PLR) and lymphocyte/monocyte ratio(LMR) on the prognosis of colorectal cancer (CRC) patients. This study aimed to evaluate the roles of the PLR and LMR in predicting the prognosis of CRC patients via meta-analysis. METHODS: Eligible studies were retrieved from the PubMed, Embase,andChina National Knowledge Infrastructure (CNKI) databases, supplemented by a manual search of references from retrieved articles...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212548/branched-chain-amino-acids-prevent-hepatic-fibrosis-and-development-of-hepatocellular-carcinoma-in-a-non-alcoholic-steatohepatitis-mouse-model
#10
Kai Takegoshi, Masao Honda, Hikari Okada, Riuta Takabatake, Naoto Matsuzawa-Nagata, Jean S Campbell, Masashi Nishikawa, Tetsuro Shimakami, Takayoshi Shirasaki, Yoshio Sakai, Taro Yamashita, Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko
Oral supplementation with branched-chain amino acids (BCAA; leucine, isoleucine, and valine) in patients with liver cirrhosis potentially suppresses the incidence of hepatocellular carcinoma (HCC) and improves event-free survival. However, the detailed mechanisms of BCAA action have not been fully elucidated. BCAA were administered to atherogenic and high-fat (Ath+HF) diet-induced nonalcoholic steatohepatitis (NASH) model mice. Liver histology, tumor incidence, and gene expression profiles were evaluated. Ath+HF diet mice developed hepatic tumors at a high frequency at 68 weeks...
February 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28211970/brain-hemorrhages-in-jacobsen-syndrome-a-retrospective-review-of-six-cases-and-clinical-recommendations
#11
Paul Grossfeld
Jacobsen syndrome is a rare chromosomal disorder caused by distal deletions in the long arm of chromosome 11. All patients with Jacobsen syndrome have Paris-Trousseau syndrome, a bleeding disorder that causes neonatal thrombocytopenia, and persistent platelet dysfunction. Despite that, to date there are no reported cases of hemorrhagic strokes occurring in patients with Jacobsen syndrome. In the last 6 years at least six cases of brain hemorrhages in patients with Jacobsen syndrome have occurred. In this report, we perform a retrospective review of these six cases...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28211910/link-between-plasminogen-activator-inhibitor-1-and-cardiovascular-risk-in-chronic-hepatitis-c-after-viral-clearance
#12
Ming-Ling Chang, Yu-Sheng Lin, Li-Heng Pao, Hsin-Chih Huang, Cheng-Tang Chiu
The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Multivariate analysis demonstrated, before anti-HCV-therapy, platelet count and PAI-1-rs1799889 genotype were associated with PAI-1 levels. Among patients with a sustained virological response (SVR, n = 445), platelet count was associated with PAI-1 level at 24 weeks post-therapy...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211870/non-apoptotic-functions-of-caspases-in-myeloid-cell-differentiation
#13
REVIEW
Stéphanie Solier, Michaela Fontenay, William Vainchenker, Nathalie Droin, Eric Solary
Subtle caspase activation is associated with the differentiation of several myeloid lineages. A tightly orchestrated dance between caspase-3 activation and the chaperone HSP70 that migrates to the nucleus to protect the master regulator GATA-1 from cleavage transiently occurs in basophilic erythroblasts and may prepare nucleus and organelle expel that occurs at the terminal phase of erythroid differentiation. A spatially restricted activation of caspase-3 occurs in maturing megakaryocytes to promote proplatelet maturation and platelet shedding in the bloodstream...
February 17, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28211801/effect-of-shear-induced-platelet-activation-on-red-blood-cell-aggregation
#14
Hoyoon Lee, Kisung Lee, Byoung-Kwon Lee, Alexander V Priezzhev, Sehyun Shin
Mechanical shear stress is one of the important factors for platelet activation. Although shear stress has been frequently utilized in many applications of diagnostic bio-equipment, there has been little consideration as to whether shear stress induces platelet activation and consequently alters hemorheological characteristics. Therefore, we investigated the effect of shear-induced platelet activation on red blood cell (RBC) aggregation. The hypothesis of the present research is as follows: Platelets activated by high shear stress secrete substances, which can affect hemorheological characteristics to promote RBC aggregation...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28211570/platelet-phagocytosis-by-granulopoietic-precursors-in-a-myelodysplastic-syndrome-overexpressing-the-p-selectin-gene
#15
Rosario M Morales-Camacho, M Dolores Serrano-Chacón, Concepción Prats-Martín, M Teresa Vargas, Ricardo Bernal, Sergio Burillo-Sanz
No abstract text is available yet for this article.
February 17, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28211270/uniform-patchy-platelets-by-seeded-heteroepitaxial-growth-of-crystallizable-polymer-blends-in-two-dimensions
#16
Ali Nazemi, Xiaoming He, Liam R MacFarlane, Robert L Harniman, Ming-Siao Hsiao, Mitchell A Winnik, Charl F J Faul, Ian Manners
Rectangular platelets formed by the self-assembly of block copolymers in selective solvents are of interest for a range of applications. Recently we showed that the seeded growth of crystallizable blends of a block copolymer and homopolymer yields well-defined, low dispersity examples of these two-dimensional (2D) structures. The key feature was the use of the same crystallizable polymer segment in the seed and blend components to enable an efficient homoepitaxial growth process. Herein we demonstrate that this 2D crystallization-driven self-assembly approach can be extended to heteropitaxial growth by the use of different crystallizable polymers with compatible crystal structures...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28211229/serum-micrornas-as-predictors-for-liver-fibrosis-staging-in-hepatitis-c-virus-associated-chronic-liver-disease-patients
#17
Olfat G Shaker, Mahmoud A Senousy
Accurate staging of liver fibrosis is important for clinical decision making and personalized management. Liver fibrosis is influenced by patients' genomics, including IFNL3 genotype and microRNA expression. However, incorporating microRNAs into fibrosis prediction algorithms has not been investigated. We examined the potential of 8 selected serum microRNAs; miR-122, miR-126, miR-129, miR-199a, miR-155, miR-203a, miR-221, and miR-223 as non-invasive biomarkers to stage liver fibrosis in HCV-associated chronic liver disease (HCV-CLD)...
February 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28211187/deletion-of-junctional-adhesion-molecule-a-from-platelets-increases-early-stage-neointima-formation-after-wire-injury-in-hyperlipidemic-mice
#18
Zhen Zhao, Tanja Vajen, Ela Karshovska, Annemiek Dickhout, Martin M Schmitt, Remco T A Megens, Philipp von Hundelshausen, Thomas A Koeppel, Tilman M Hackeng, Christian Weber, Rory R Koenen
Platelets play an important role in the pathogenesis of vascular remodelling after injury. Junctional adhesion molecule A (JAM-A) was recently described to regulate platelet activation. Specific deletion of JAM-A from platelets resulted in increased reactivity and in accelerated progression of atherosclerosis. The aim of this study was to investigate the specific contribution of platelet-derived JAM-A to neointima formation after vascular injury. Mice with or without platelet-specific (tr)JAM-A-deficiency in an apolipoprotein e (apoe(-/-) ) background underwent wire-induced injury of the common carotid artery...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28211169/a-first-in-human-study-of-ds-1040-an-inhibitor-of-the-activated-form-of-thrombin-activatable-fibrinolysis-inhibitor-in-healthy-subjects
#19
Jin Zhou, Jarema Kochan, Ophelia Yin, Vance Warren, Cynthia Zamora, George Atiee, Joseph Pav, Yasushi Orihashi, Vijay Vashi, Victor Dishy
BACKGROUND: Current treatments for acute ischemic stroke and venous thromboembolism, such as recombinant tissue plasminogen activator and thrombectomy, are limited by a narrow time window and the risk of bleeding. DS-1040 is a novel low-molecular weight compound inhibiting the activated form of thrombin-activatable fibrinolysis inhibitor (TAFIa), developed as a fibrinolysis enhancer for treatment of thromboembolic diseases. OBJECTIVES: This first-in-human, randomized, placebo-controlled, three-part, phase 1 study was conducted to evaluate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of DS-1040 in healthy subjects...
February 17, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28210898/flow-cytometric-analysis-reveals-the-high-levels-of-platelet-activation-parameters-in-circulation-of-multiple-sclerosis-patients
#20
Agnieszka Morel, Joanna Rywaniak, Michał Bijak, Elżbieta Miller, Marta Niwald, Joanna Saluk
The epidemiological studies confirm an increased risk of cardiovascular disease in multiple sclerosis, especially prothrombotic events directly associated with abnormal platelet activity. The aim of our study was to investigate the level of blood platelet activation in the circulation of patients with chronic phase of multiple sclerosis (SP MS) and their reactivity in response to typical platelets' physiological agonists. We examined 85 SP MS patients diagnosed according to the revised McDonald's criteria and 50 healthy volunteers as a control group...
February 16, 2017: Molecular and Cellular Biochemistry
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