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undifferentiated arthritis

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https://www.readbyqxmd.com/read/29431174/small-fiber-neuropathy-presenting-during-the-antecedent-period-of-undifferentiated-arthritis-prior-to-rheumatoid-arthritis
#1
Julius Birnbaum
No abstract text is available yet for this article.
December 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29404675/detection-of-shigella-spp-nucleic-acids-in-the-synovial-tissue-of-tunisian-rheumatoid-arthritis-patients-and-other-forms-of-arthritis-by-quantitative-real-time-polymerase-chain-reaction
#2
Mariam Siala, Markus Rihl, Hanen Sellami, Abir Znazen, Nadia Sassi, Lilia Laadhar, Radhouane Gdoura, Imen Belghuith, Dalila Mrabet, Sofien Baklouti, Slaheddine Sellami, Jean Sibilia, Hela Fourati, Adnene Hammami, Ilhem Cheour
Enterobacterial components in the joints of patients are believed to contribute to a perpetuating inflammation leading to a reactive arthritis (ReA), a condition in which microbial agents cannot be recovered from the joint. At present, it is unclear whether nucleic acids from Shigella spp. are playing a pathogenic role in causing not only ReA but also other forms of arthritis. Quantitative real-time polymerase chain reaction assay (qPCR) is the method of choice for the identification of bacteria within the synovium...
February 5, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29352841/predict-rheumatoid-arthritis-conversion-from-undifferentiated-arthritis-with-dynamic-contrast-enhanced-mri-and-laboratory-indexes
#3
Xinwei Lei, Huixia Li, Ying Zhan, Jin Qu
OBJECTIVES: To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). METHODS: A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29259045/risk-of-cardiac-rhythm-disturbances-and-aortic-regurgitation-in-different-spondyloarthritis-subtypes-in-comparison-with-general-population-a-register-based-study-from-sweden
#4
Karin Bengtsson, Helena Forsblad-d'Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling, Lennart T H Jacobsson
OBJECTIVES: To describe the incidence of atrioventricular (AV) block II-III, atrial fibrillation (AF), pacemaker implantation (PM) and aortic regurgitation in patients with ankylosing spondylitis (AS), undifferentiated spondyloarthritis (uSpA) and psoriatic arthritis (PsA) compared with the general population (GP) and with each other. METHODS: A prospective nationwide study with cohorts of patients with AS (n=6448), PsA (n=16 063) and uSpA (n=5190) and a GP (n=2 66 435) cohort, identified in 2001-2009 in the Swedish National Patient and Population registers...
December 19, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29221601/magnetic-resonance-imaging-in-individuals-at-risk-of-rheumatoid-arthritis
#5
REVIEW
Laura Hunt, Gisela Eugénio, Andrew J Grainger
Individuals with rheumatoid arthritis (RA) benefit from early diagnosis and initiation of therapy. There can be delays in both due to diagnostic uncertainties. Imaging modalities, including magnetic resonance imaging (MRI), can detect inflammation earlier than clinical examination alone in early RA patients. Furthermore, the predictive role of MRI for the future development of RA has recently been explored in 'at-risk' individuals. This review details the use of MRI in early and undifferentiated arthritis and summarises the studies to date in individuals at risk of RA...
February 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#6
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29185958/are-rheumatologists-adhering-to-the-concepts-window-of-opportunity-and-treat-to-target-earlier-and-more-intense-disease-modifying-anti-rheumatic-drug-treatment-over-time-in-patients-with-early-arthritis-in-the-pearl-study
#7
Esther Toledano, Ana M Ortiz, Jose Ivorra-Cortes, Nuria Montes, Amada Beltran, Luis Rodríguez-Rodriguez, Loreto Carmona, Isidoro González-Álvaro
OBJECTIVES: To analyse changes over time in the treatment with disease modifying anti-rheumatic drugs and biological therapies prescribed to patients from an early arthritis register and whether these changes had an impact on their outcome. METHODS: This was a longitudinal retrospective 2-year study based on data collected in the PEARL study. The population was clustered in three groups depending on year of symptoms onset (2000-2004, 2005-2009, 2010-2014). Intensity of disease-modifying anti-rheumatic drug treatment was calculated and the percentage of patients receiving biological therapy during the first 2-year follow-up was collected...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29161466/treating-early-undifferentiated-arthritis-a-systematic-review-and-meta-analysis-of-direct-and-indirect-trial-evidence
#8
Maria A Lopez-Olivo, Voke Kakpovbia-Eshareturi, Jude des Bordes, Andrea Barbo, Robin Christensen, Maria E Suarez-Almazor
OBJECTIVE: We undertook a systematic review and meta-analysis of direct and indirect trial evidence to evaluate the efficacy of treatments for patients with undifferentiated arthritis (UA). METHODS: We searched four electronic databases from inception to January 2016, clinicaltrials. gov, and bibliographies of relevant articles. Two reviewers independently screened and evaluated the studies. The primary outcome was development of rheumatoid arthritis (RA). RESULTS: Nine studies were included...
November 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29154446/transmission-electron-microscopy-helpfulness-in-whipple-s-disease-masked-by-immunosuppressant-therapy-for-arthritis
#9
Alessandra Loiodice, Giuseppe Losurdo, Andrea Iannone, Roberta Rossi, Maria Grazia Fiore, Domenico Piscitelli
A 61-year-old woman received a diagnosis of undifferentiated non-erosive arthritis in 2010 and assumed methotrexate and steroids in 2014. After 1 year, she experienced watery diarrhea, vomiting, fever, weight loss, and severe hypoalbuminemia, thus being admitted into our Unit. Esophagogastroduodenoscopy showed duodenal lymphangiectasia and duodenal biopsy samples several foamy PAS-positive macrophages and villous subtotal atrophy. Transmission electron microscope demonstrated several extracellular and intracellular rod-shaped bacteria (Tropheryma whipplei)...
November 20, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28970207/clinical-and-radiological-outcomes-of-5-year-drug-free-remission-steered-treatment-in-patients-with-early-arthritis-improved-study
#10
Gülşah Akdemir, Lotte Heimans, Sytske Anne Bergstra, Robbert J Goekoop, Maikel van Oosterhout, Johannes H L M van Groenendael, André J Peeters, Gerda M Steup-Beekman, Leroy R Lard, Peter B J de Sonnaville, Bernard A M Grillet, Tom W J Huizinga, Cornelia F Allaart
OBJECTIVES: To determine the 5-year outcomes of early remission induction therapy followed by targeted treatment aimed at drug-free remission (DFR) in patients with early arthritis. METHODS: In 12 hospitals, 610 patients with early (<2 years) rheumatoid arthritis (RA) or undifferentiated arthritis (UA) started on methotrexate (MTX) 25 mg/week and prednisone (60 mg/day tapered to 7.5 mg/day). Patients not in early remission (Disease Activity Score <1...
September 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28962586/further-treatment-intensification-in-undifferentiated-and-rheumatoid-arthritis-patients-already-in-low-disease-activity-has-limited-benefit-towards-physical-functioning
#11
Sytske Anne Bergstra, Otto Olivas, Gülşah Akdemir, Naghmeh Riyazi, Gerard Collée, Johannes H L M van Groenendael, Robert B M Landewé, Cornelia F Allaart
BACKGROUND: It is recommended to optimise treatment as long as a predefined treatment target is not met, but should the aim be remission if patients are in low disease activity (LDA)? The aim of this study was to assess if, in patients with rheumatoid arthritis (RA) or patients with undifferentiated arthritis (UA) with Disease Activity Score (DAS) ≤ 2.4 (LDA), treatment intensification results in better functional ability. METHODS: In the IMPROVED study 610 patients with early RA or UA were treated with methotrexate + tapered high-dose prednisone...
September 30, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28957551/using-a-reference-when-defining-an-abnormal-mri-reduces-false-positive-mri-results-a-longitudinal-study-in-two-cohorts-at-risk-for-rheumatoid-arthritis
#12
Aleid C Boer, Leonie E Burgers, Lukas Mangnus, Robin M Ten Brinck, Wouter P Nieuwenhuis, Hanna W van Steenbergen, Monique Reijnierse, Tom W J Huizinga, Annette H M van der Helm van Mil
Objectives: The use of hand and foot MRI in the diagnostic process of RA has been advocated. Recent studies showed that MRI is helpful in predicting progression from clinically suspect arthralgia (CSA) to clinical arthritis, and from undifferentiated arthritis (UA) to RA. Symptom-free persons can also show inflammation on MRI. This study aimed to evaluate if MRI findings in symptom-free volunteers are relevant when defining a positive MRI. Methods: Two hundred and twenty-five CSA patients and two hundred and one UA patients underwent MRI of MCP, wrist and MTP joints at baseline and were followed for 1 year on progression to arthritis and RA, respectively, as reported previously...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28943073/the-reliability-and-validity-of-a-venezuelan-version-of-the-bath-ankylosing-spondylitis-functional-index-basfi-and-bath-ankylosing-spondylitis-disease-activity-index-basdai
#13
Mayra Rauseo Vera, Luis Arturo Gutiérrez-González, Irama Maldonado, Soham Al Snih
INTRODUCTION: Spondyloarthropathies (SpA) are disabling diseases with a prevalence of 1.9% in the general population. The indices designed for monitoring the disease should be valid, reliable and cross-culturally adapted for decision-making concerning the appropriate treatment. Changing an adjective or pronoun in a self-administered questionnaire could be the big difference in condensing an idea in a few words and transmitting that concept to all those who share the same language. OBJECTIVES: To develop a Venezuelan version of the original English version of the BASDAI/BASFI and to evaluate its reliability and validity in Venezuelan patients with SpA...
September 21, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28910361/fever-as-an-initial-manifestation-of-spondyloarthritis-a-retrospective-study
#14
Se Jin Byun, William Han Bae, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
OBJECTIVES: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria. METHODS: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic...
2017: PloS One
https://www.readbyqxmd.com/read/28835429/a-rare-case-of-pulmonary-toxoplasmosis-in-a-patient-with-undifferentiated-inflammatory-arthritis-on-chronic-methotrexate-and-corticosteroid-therapy
#15
Abdullateef Abdulkareem, Ryan Steven D'Souza, Nitin Patel, Anthony A Donato
Pulmonary toxoplasmosis is a serious pulmonary condition caused by the protozoan Toxoplasma gondii It typically affects immunocompromised patients presenting acutely with cough, fever, myalgias, arthralgias and lymphadenopathy, and chronically with persistent cough and dyspnoea. Because of its protean features, it can mimic many more common lung conditions in the immunocompromised patient, including atypical pneumonia, Pneumocystis pneumonia and interstitial lung disease. In this article, we present the case of a 55-year-old woman who presented to our hospital with persistent dyspnoea and cough, initially suspected to have an arthritis-related interstitial lung disease...
August 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28812455/prognostic-factors-for-change-in-self-reported-anxiety-and-depression-in-spondyloarthritis-patients-data-from-the-population-based-spascania-cohort-from-southern-sweden
#16
Jjl Meesters, S Bergman, E Haglund, Lth Jacobsson, I F Petersson, A Bremander
OBJECTIVES: Anxiety and depression symptoms are more common in patients with spondyloarthritis (SpA) than in the general population. This study describes prognostic factors for change in self-reported anxiety and depression over 2 years in a well-defined SpA cohort. METHOD: In 2009, 3716 adult patients from the SpAScania cohort received a postal questionnaire to assess quality of life (QoL) and physical and mental functioning. A follow-up survey was performed in 2011...
August 16, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28798051/role-of-erosions-typical-of-rheumatoid-arthritis-in-the-2010-acr-eular-rheumatoid-arthritis-classification-criteria-results-from-a-very-early-arthritis-cohort
#17
Gina Hetland Brinkmann, Ellen S Norli, Pernille Bøyesen, Désirée van der Heijde, Lars Grøvle, Anne J Haugen, Halvor Nygaard, Olav Bjørneboe, Cathrine Thunem, Tore K Kvien, Maria D Mjaavatten, Elisabeth Lie
OBJECTIVE: To determine how the European League Against Rheumatism (EULAR) definition of erosive disease (erosion criterion) contributes to the number of patients classified as rheumatoid arthritis (RA) according to the 2010 American College of Rheumatology/EULAR RA classification criteria (2010 RA criteria) in an early arthritis cohort. METHODS: Patients from the observational study Norwegian Very Early Arthritis Clinic with joint swelling ≤16 weeks, a clinical diagnosis of RA or undifferentiated arthritis, and radiographs of hands and feet were included...
November 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28791449/incidence-of-inflammatory-joint-diseases-in-finland-results-from-a-population-based-epidemiological-study
#18
A Kononoff, L Arstila, P Pussinen, H Kautiainen, P Elfving, E Savolainen, H Niinisalo, J Rutanen, O Marjoniemi, O Kaipiainen-Seppänen
The objective of the study was to assess the incidence of inflammatory joint diseases and possible environmental factors contributing to their occurrence in a defined population in Finland. All rheumatologists practising in the Northern Savo rheumatological outpatient departments collected data on their newly diagnosed patients with an inflammatory joint disease in 2010. Antibodies to Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) were determined from patients with various arthritides...
October 2017: Rheumatology International
https://www.readbyqxmd.com/read/28748510/clinical-characteristics-of-autoimmune-rheumatic-disease-related-organizing-pneumonia
#19
Xin Dong, Yi Zheng, Li Wang, Wen-Hui Chen, Yun-Gang Zhang, Qiang Fu
To study the clinical characteristics of autoimmune rheumatic disease-related organizing pneumonia (AIRD-OP), the clinical presentation, radiological findings, treatment, and outcome of AIRD-OP patients were analyzed, in comparison with patients with cryptogenic organizing pneumonia (COP). A total of 131 OP patients were identified, including 57 cases of AIRD-OP, 35 cases of COP, and 39 cases of other disease-related OPs. Among AIRD-OP patients, 36 (63%) presented the symptoms of OP at onset. The primary disease of AIRDs included Sjogren's syndrome (38%), polymyositis/dermatomyositis (23%), rheumatoid arthritis (23%), and undifferentiated AIRD...
July 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28663326/clinical-associations-of-the-positive-anti-ro52-without-ro60-autoantibodies-undifferentiated-connective-tissue-diseases
#20
Sai H K Murng, Moira Thomas
AIMS: Autoantibodies targeting Ro52 and Ro60 antigens are historically reported as anti SSA/Ro. In general anti SSA/Ro results are either anti Ro52+Ro60+ or anti Ro52-Ro60+ antibodies. Anti Ro52 without anti Ro60 (Ro52+ Ro60-) antibodies are often not reported routinely. This study intends to review the potential significance of these autoantibodies in the management of connective tissue diseases. METHOD: A retrospective survey of Ro52+Ro60- was carried out as part of the service evaluation of extractable nuclear antigen antibodies (ENA) reporting from the immunology laboratory, the NHS Greater Glasgow and Clyde (GGC), UK...
June 29, 2017: Journal of Clinical Pathology
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