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https://www.readbyqxmd.com/read/29927712/case-series-rheumatological-manifestations-attributed-to-exposure-to-libby-asbestiform-amphiboles
#1
Roger Diegel, Brad Black, Jean C Pfau, Tracy McNew, Curtis Noonan, Raja Flores
An increased risk for Systemic Autoimmune Diseases (SAID) has been reported in Libby, Montana, where extensive exposures to fibrous amphiboles occurred due to mining and use of asbestos-laden vermiculite. In addition, positive antinuclear autoantibody tests are associated with exposure to Libby Asbestiform Amphiboles (LAA) in both humans and mice. Among 6603 subjects who underwent health screening at the Center for Asbestos Related Diseases (CARD, Libby MT), 13.8% were diagnosed with an autoimmune disease, with prevalence values for the most common SAID being significantly higher than expected in the United States...
June 21, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29884751/ability-of-disease-modifying-antirheumatic-drugs-to-prevent-or-delay-rheumatoid-arthritis-onset-a-systematic-literature-review-and-meta-analysis
#2
REVIEW
Stéphane Hilliquin, Benjamin Hugues, Stéphane Mitrovic, Laure Gossec, Bruno Fautrel
BACKGROUND: Recent advances in knowledge of the pathogenesis of rheumatoid arthritis (RA) has led to promoting very early intervention. OBJECTIVES: To assess the efficacy of therapeutic interventions in preventing or delaying RA onset with a systematic literature review (SLR) and meta-analysis (MA). METHODS: The SLR aimed to include all reports of randomised controlled trials of disease-modifying antirheumatic drugs or glucocorticoids used in patients presenting genetic and/or environmental risk factors for RA and/or systemic autoimmunity associated with RA, and/or symptoms without clinical arthritis and/or unclassified arthritis and in patients with RA...
June 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29883326/-methods-of-efficacy-assessment-of-the-knee-joint-radiosynoviorthesis-personal-experience
#3
Robert Zwolak, Maria Majdan
OBJECTIVE: Introduction: Radiosynoviorthesis (RS) is local method of treatment of remittent joint effusions among patients who obtained general improvement after disease modifying anti-rheumatic drugs therapy but one or a few joints stay resistant to this treatment and intraarticular corticosteroids injections. The aim: The attempt to identification methods of efficacy assessment of the 90yttrium knee joint RS. PATIENTS AND METHODS: Material and methods: The study group consisted of 43 patients with rheumatoid arthritis (RA) and 19 patients with inflammatory spondyloarthropaties (SPA) where 8 patients were treated for ankylosing spondylitis (AS), 4 for psoriatic arthritis (PsA) and 7 due to undifferentiated inflammatory spondyloarthropaties (USPA)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29863218/brucellosis-in-adults-and-children-a-10-year-case-series-at-two-large-academic-hospitals-in-houston-texas
#4
Jose A Serpa, Sheena Knights, Dimitrios Farmakiotis, Judith Campbell
OBJECTIVES: Brucellosis is one of the most common zoonoses worldwide. Most cases in the United States occur among travelers or immigrants from endemic regions, mostly Central America. In this study, we aimed at describing and comparing the epidemiology and clinical presentation of brucellosis in pediatric and adult patients at two large tertiary care centers in Houston, Texas. METHODS: We identified patients diagnosed as having brucellosis between January 2000 and December 2009 by searching electronic medical records and reviewing microbiology records for positive cultures...
June 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29764383/an-automated-algorithm-for-the-detection-of-cortical-interruptions-and-its-underlying-loss-of-trabecular-bone-a-reproducibility-study
#5
M Peters, J de Jong, A Scharmga, A van Tubergen, P Geusens, D Loeffen, R Weijers, S K Boyd, C Barnabe, K S Stok, B van Rietbergen, J van den Bergh
BACKGROUND: We developed a semi-automated algorithm that detects cortical interruptions in finger joints using high-resolution peripheral quantitative computed tomography (HR-pQCT), and extended it with trabecular void volume measurement. In this study we tested the reproducibility of the algorithm using scan/re-scan data. METHODS: Second and third metacarpophalangeal joints of 21 subjects (mean age 49 (SD 11) years, 17 early rheumatoid arthritis and 4 undifferentiated arthritis, all diagnosed < 1 year ago) were imaged twice by HR-pQCT on the same day with repositioning between scans...
May 15, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29724250/does-information-on-novel-identified-autoantibodies-contribute-to-predicting-the-progression-from-undifferentiated-arthritis-to-rheumatoid-arthritis-a-study-on-anti-carp-antibodies-as-an-example
#6
Debbie M Boeters, Leendert A Trouw, Annette H M van der Helm-van Mil, Hanna W van Steenbergen
BACKGROUND: The presence of autoantibodies is considered an important characteristic of rheumatoid arthritis (RA); therefore, both anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) are included in the 2010 classification criteria for rheumatoid arthritis (RA). However, a considerable number of RA patients lack both these autoantibodies. Recently, several novel autoantibodies have been identified but their value for the classification of RA patients is unclear. Therefore, we studied the value of novel autoantibodies using the presence of anticarbamylated protein (anti-CarP) antibodies as an example for predicting RA development in patients with undifferentiated arthritis (UA)...
May 3, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29720240/integrative-analysis-reveals-cd38-as-a-therapeutic-target-for-plasma-cell-rich-pre-disease-and-established-rheumatoid-arthritis-and-systemic-lupus-erythematosus
#7
Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D Wechalekar, Malcolm D Smith, Susanna M Proudman, Douglas J Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams, Christopher Chiu, Michael Sharp, John Alvarez, Ian Anderson, Loui Madakamutil, Sunil Nagpal, Yanxia Guo
BACKGROUND: Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma cell/plasmablast depletion mechanism by daratumumab in the treatment of patients with RA and SLE. METHODS: RNA-sequencing analysis of synovial biopsies from various stages of RA disease progression, flow cytometry analysis of peripheral blood mononuclear cells (PBMC) from patients with RA or SLE and healthy donors, immunohistochemistry assessment (IHC) of synovial biopsies from patients with early RA, and ex vivo immune cell depletion assays using daratumumab (an anti-CD38 monoclonal antibody) were used to assess CD38 as a therapeutic target...
May 2, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29686437/monocyte-related-biomarkers-of-rheumatoid-arthritis-development-in-undifferentiated-arthritis-patients-a-pilot-study
#8
Weronika Kurowska, Ewa Kuca-Warnawin, Anna Radzikowska, Michał Jakubaszek, Maria Maślińska, Brygida Kwiatkowska, Włodzimierz Maśliński
Objectives: Enhanced/disturbed activities of monocytes are crucial for perpetuation and for development of rheumatoid arthritis (RA). Therefore, knowledge about monocyte activities and regulation of molecular pathways operating within monocytes early in the course of RA development may help to predict the progression to the full-blown disease. We aimed to investigate the profile of miRNAs expression in circulating monocytes and monocyte-related cytokines in sera of individuals at undifferentiated arthritis (UA) stage, wich could serve as new biomarkers for RA development...
2018: Reumatologia
https://www.readbyqxmd.com/read/29672807/imaging-to-differentiate-the-various-forms-of-seronegative-arthritis
#9
Iris Eshed, Kay-Geert A Hermann, Anna Zejden, Iwona Sudoł-Szopińska
Spondyloarthritis (SpA) is a group of diseases characterized by back pain, spinal inflammation, human leukocyte antigen-B27 positivity, and peripheral findings such as dactylitis, enthesitis, and uveitis. It includes ankylosing spondylitis, psoriatic arthritis, reactive arthritis, arthritis associated with inflammatory bowel disease, and undifferentiated SpA. The role of imaging in the diagnosis, management, and follow-up of patients with SpA has become dramatically more important with the introduction of new therapies such as tumor necrosis factor-α inhibitors...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29667098/treatment-patterns-among-patients-with-rheumatic-disease-rheumatoid-arthritis-ra-ankylosing-spondylitis-as-psoriatic-arthritis-psa-and-undifferentiated-arthritis-una-treated-with-subcutaneous-tnf-inhibitors
#10
Kathleen Tymms, Geoff Littlejohn, Hedley Griffiths, Julien de Jager, Paul Bird, Fred Joshua, Peter Nash, Malcolm Handel, Hamish McManus, Belinda E Butcher, Peter Youssef
The aim was to describe the real-world treatment persistence of subcutaneous TNF inhibitors (TNFi) for patients with inflammatory rheumatic disease newly initiating treatment with biologic disease-modifying antirheumatic drugs (bDMARD). This was a retrospective cohort study that extracted data for new users of TNFi between 1 August 2010 and 31 August 2016 from the Australian Optimising Patient outcome in Australian RheumatoLogy (OPAL) registry. Patients were 1:1 propensity-score matched with golimumab based on their age, sex, year of index, C-reactive protein level, baseline treatment combination and disease...
June 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29610697/a-case-of-spondyloarthritis-in-patient-affected-by-unicentric-castleman-s-disease-effectively-managed-with-surgery-resection-and-tocilizumab-treatment
#11
M Filippini, S Cartella, O Bonzanini, E Morello, A Tincani
A 38-year-old woman was referred to our hospital for rheumatologic manifestations (migrant arthritis and tenosynovitis), without psoriasis or family history of psoriasis, gastroenteric manifestations, or recent genitourinary infections. The instrumental and laboratory tests have suggested a diagnosis of undifferentiated seronegative HLA-B27-positive spondyloarthritis with predominantly peripheral involvement. The symptoms were very severe and resistant to anti-inflammatory drugs and steroids. She had a history of hyaline-vascular unicentric Castleman's disease (HBV, HIV, and HHV-8 negative) treated with surgery resection...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29606666/comparative-analysis-and-predictors-of-10-year-tumor-necrosis-factor-inhibitors-drug-survival-in-patients-with-spondyloarthritis-first-year-response-predicts-longterm-drug-persistence
#12
Irini D Flouri, Theodora E Markatseli, Kyriaki A Boki, Ioannis Papadopoulos, Fotini N Skopouli, Paraskevi V Voulgari, Loukas Settas, Dimitrios Zisopoulos, Alexios Iliopoulos, Pierre Geborek, Alexandros A Drosos, Dimitrios T Boumpas, Prodromos Sidiropoulos
OBJECTIVE: To evaluate the 10-year drug survival of the first tumor necrosis factor inhibitor (TNFi) administered to patients with spondyloarthritis (SpA) overall and comparatively between SpA subsets, and to identify predictors of drug retention. METHODS: Patients with SpA in the Hellenic Registry of Biologic Therapies, a prospective multicenter observational cohort, starting their first TNFi between 2004-2014 were analyzed. Kaplan-Meier curves and Cox regression models were used...
June 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29574865/rheumatologic-complications-in-a-cohort-of-227-patients-with-common-variable-immunodeficiency
#13
G Azizi, F Kiaee, E Hedayat, R Yazdani, E Dolatshahi, T Alinia, L Sharifi, H Mohammadi, H Kavosi, F Jadidi-Niaragh, V Ziaee, H Abolhassani, A Aghamohammadi
Common variable immunodeficiency (CVID) is the most prevalent symptomatic type of human primary immunodeficiency diseases (PID). Clinically, CVID is characterized by increased susceptibility to infections and a wide variety of autoimmune and rheumatologic disorders. All patients with CVID registered in Iranian PID Registry (IPIDR) were enrolled in this retrospective cohort study. We investigated the frequency of rheumatologic diseases and its association with immunological and clinical phenotypes in patients with CVID...
May 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29573557/the-correlation-between-the-childhood-health-assessment-questionnaire-and-disease-activity-in-juvenile-idiopathic-arthritis
#14
Watchareewan Sontichai, Soamarat Vilaiyuk
BACKGROUND: The Childhood Health Assessment Questionnaire (CHAQ) has been adapted from the Stanford Health Assessment Questionnaire for assessing functional ability in children. The present study aimed to determine the correlation between CHAQ and disease activity in juvenile idiopathic arthritis (JIA) during active and inactive disease. METHODS: JIA patients in the Pediatric Department, Ramathibodi Hospital, between January 2011 and December 2013, were included in the study...
March 24, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29558346/-methods-of-efficacy-assessment-of-the-knee-joint-radiosynoviorthesis-personal-experience
#15
Robert Zwolak, Maria Majdan
OBJECTIVE: Introduction: Radiosynoviorthesis (RS) is local method of treatment of remittent joint effusions among patients who obtained general improvement after disease modifying anti-rheumatic drugs therapy but one or a few joints stay resistant to this treatment and intraarticular corticosteroids injections. The aim: The attempt to identification methods of efficacy assessment of the 90yttrium knee joint RS. PATIENTS AND METHODS: Material and methods: The study group consisted of 43 patients with rheumatoid arthritis (RA) and 19 patients with inflammatory spondyloarthropaties (SPA) where 8 patients were treated for ankylosing spondylitis (AS), 4 for psoriatic arthritis (PsA) and 7 due to undifferentiated inflammatory spondyloarthropaties (USPA)...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29533750/in-early-arthritis-patients-high-haq-at-baseline-and-das28-at-three-months-predict-suboptimal-outcomes-at-two-years-a-retrospective-cohort-study
#16
Antonis Fanouriakis, Ioannis Papalopoulos, Irini Gergianaki, Giorgis Spyrou, Abdulsamet Erden, Panagiota Rapsomaniki, Maria Terizaki, Nestor Avgoustidis, Argyro Repa, Nikolaos Kougkas, George Bertsias, Dimitrios T Boumpas, Prodromos I Sidiropoulos
OBJECTIVES: Early arthritis clinics (EAC) aim to improve rheumatoid arthritis (RA) outcomes by tailoring treatment targeting to remission. Our aim was to analyse disease course and relevant predictors over 2 years in early arthritis; we also assessed the applicability of the "treat-to-target approach" in a real-life EAC. METHODS: Patients with early arthritis recruited at the EAC of the University Hospital of Heraklion were followed prospectively according to a follow-up protocol for two years, without implementing a pre-specified treatment protocol, to capture real-life practices...
February 28, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29489833/immune-checkpoint-inhibitor-pd-1-pathway-is-down-regulated-in-synovium-at-various-stages-of-rheumatoid-arthritis-disease-progression
#17
Yanxia Guo, Alice M Walsh, Mary Canavan, Mihir D Wechalekar, Suzanne Cole, Xuefeng Yin, Brittney Scott, Mathew Loza, Carl Orr, Trudy McGarry, Michele Bombardieri, Frances Humby, Susanna M Proudman, Costantino Pitzalis, Malcolm D Smith, Joshua R Friedman, Ian Anderson, Loui Madakamutil, Douglas J Veale, Ursula Fearon, Sunil Nagpal
Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multiple cancer types, concomitant with immune-related adverse events, including arthralgia and inflammatory arthritis (IA) in some patients. Herein, using Nivolumab (anti-PD-1 antagonist)-responsive genes along with transcriptomics of synovial tissue from multiple stages of rheumatoid arthritis (RA) disease progression, we have interrogated the activity status of PD-1 pathway during RA development...
2018: PloS One
https://www.readbyqxmd.com/read/29468290/-early-undifferentiated-arthritis
#18
Raphael Micheroli, Adrian Ciurea
Early recognition and treatment of inflammatory arthritis is imperative for the further course of the disease. Patients with inflammatory arthritis should be referred as early as possible to a rheumatologist for further management. A combination of anamnesis, clinical examination, imaging and laboratory measurements enable a differential diagnosis. If a specific diagnosis is not possible, the disease is called early undifferentiated arthritis. Early effective treatment should be instituted for those at risk of developing persistent and/or erosive arthritis...
March 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29465359/socio-economic-inequalities-in-occurrence-and-health-care-costs-in-rheumatic-and-musculoskeletal-diseases-results-from-a-spanish-population-based-study-including-1-9-million-persons
#19
Polina Putrik, Sofia Ramiro, Juan F Orueta, Andras Keszei, Edurne Alonso Moran, Roberto Nuño Solinis, Annelies Boonen
OBJECTIVES: To explore and compare the impact of socio-economic deprivation on the occurrence of the major rheumatic and musculoskeletal diseases (RMDs) and health care costs. METHODS: Data on diagnoses, socio-demographics and health care costs of the entire adult population of the Basque Country (Spain) was used. Area deprivation index included five categories (1 to 5 (most deprived)). Cost categories included primary and specialist care, emergency room, hospitalisations, and drug prescriptions...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29461959/one-year-in-review-2017-spondyloarthritis
#20
REVIEW
Riccardo Terenzi, Sara Monti, Giulia Tesei, Linda Carli
The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority of people with this disease have either psoriatic arthritis or axial spondyloarthritis, which includes ankylosing spondylitis. Less common subgroups are enteropathic SpA, which is associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis), reactive arthritis, which can occur in people following gastrointestinal or genitourinary infections and undifferentiated SpA, that does not meet the diagnostic criteria of the other subgroups at onset, but that may evolve to do so later...
January 2018: Clinical and Experimental Rheumatology
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