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https://www.readbyqxmd.com/read/28625707/-algorithms-based-on-medico-administrative-data-in-the-field-of-endocrine-nutritional-and-metabolic-diseases-especially-diabetes
#1
S Fosse-Edorh, A Rigou, S Morin, L Fezeu, L Mandereau-Bruno, A Fagot-Campagna
BACKGROUND: Medico-administrative databases represent a very interesting source of information in the field of endocrine, nutritional and metabolic diseases. The objective of this article is to describe the early works of the Redsiam working group in this field. METHODS: Algorithms developed in France in the field of diabetes, the treatment of dyslipidemia, precocious puberty, and bariatric surgery based on the National Inter-schema Information System on Health Insurance (SNIIRAM) data were identified and described...
June 15, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28597618/effects-of-resistance-training-overtraining-and-early-specialization-on-youth-athletes
#2
Benjamin K Walters, Connor R Read, A Reed Estes
INTRODUCTION: In 2014, 60 million youth ages 6-18 participated in some form of generalized athletics. 3.5 million children are injured annually participating in organized sport or recreational activities. While sound physical education can decrease the burden of youth sports injuries, the median annual physical education budget of $764 for United States elementary, middle and high schools may not allow enough flexibility to apply evidenced-based guidelines. EVIDENCE ACQUISITION: The topics were selected after a careful review of the 2016 National Strength and Conditioning Association Position Statement on Long-Term Athletic Development...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28591479/hypothalamic-hamartoma-with-epilepsy-review-of-endocrine-comorbidity
#3
REVIEW
Victor S Harrison, Oliver Oatman, John F Kerrigan
The most common, and usually the only, endocrine disturbance in patients with hypothalamic hamartoma (HH) and epilepsy is central precocious puberty (CPP). The mechanism for CPP associated with HH may relate to ectopic generation and pulsatile release of gonadotropin-releasing hormone (GnRH) from the HH, but this remains an unproven hypothesis. Possible regulators of GnRH release that are intrinsic to HH tissue include the following: (1) glial factors (such as transforming growth factor α[TGFα) and (2) γ-aminobutyric acid (GABA)-mediated excitation...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28508600/endocrine-disorders-developing-after-surgical-intervention-of-craniopharyngioma-in-children
#4
Kyrillus S Shohdy, Wegdan Rashad
Craniopharyngiomas, albeit their benign nature, can cause severe damage to visual, hypothalamic, endocrine and neurologic functions which make their total resection an inevitable approach to save the patient's life. However, significant therapy-related long term complications make those traditional treatment options debatable and hazardous. This review will focus on the various complications that affect the childrens' quality of life considerably such as, diabetes insipidus, precocious puberty and hypothalamic obesity...
March 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28506340/-endocrine-and-metabolic-features-of-female-children-with-prader-willi-syndrome-an-analysis-of-4-cases
#5
Mo-Ling Wu, Juan Li, Yu Ding, Yao Chen, Guo-Ying Chang, Xiu-Min Wang, Jian Wang, Yi-Ping Shen
This article reports the clinical features and endocrine and metabolic features of 4 children with Prader-Willi syndrome (PWS). All the patients were female and aged 6-12 years at diagnosis. All of them had clinical manifestations of obesity, unusual facies, developmental retardation, and intellectual disability. Genetic detection showed that 2 patients had paternal deletion of the 15q11.2-q13 region, one patient had maternal autodiploid in the 15q11.2-q13 region, and one patient had no abnormality in the 15q11...
May 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28437788/high-prevalence-of-polycystic-ovary-syndrome-in-type-1-diabetes-mellitus-adolescents-is-there-a-difference-depending-on-the-nih-and-rotterdam-criteria
#6
Kanetee Busiah, Ana Colmenares, Maud Bidet, Nadia Tubiana-Rufi, Claire Levy-Marchal, Christine Delcroix, Paul Jacquin, Delphine Martin, Lila Benadjaoud, Evelyne Jacqz-Aigrain, Kathleen Laborde, Jean-Jacques Robert, Dinane Samara-Boustani, Michel Polak
BACKGROUND: Polycystic ovary syndrome (PCOS) is more frequently observed in type 1 diabetes mellitus (T1DM) adult women than in nondiabetic women. No such prevalence has yet been studied in adolescent girls with T1DM. AIM: The aim of this study was to evaluate the prevalence of PCOS in adolescent girls with T1DM and to determine the clinical and hormonal features associated with the disorder. METHODS: A cross-sectional study of 53 adolescent girls (gynecological age >2 years) referred for routine evaluation for T1DM was conducted...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28410120/snp_tata_comparator-genomewide-landmarks-for-preventive-personalized-medicine
#7
REVIEW
Mikhail Ponomarenko, Dmitry Rasskazov, Irina Chadaeva, Ekaterina Sharypova, Petr Ponomarenko, Olga Arkova, Elena Kashina, Nikita Ivanisenko, Dmitry Zhechev, Ludmila Savinkova, Nikolay Kolchanov
Year after year, conditions, quality, and duration of human lives have been improving due to the progress of science, technology, education, and medicine, which however has a downside. Owing to improvement in children's nutrition, developmental acceleration occurs that imbalances a child's system. Because of virtual worlds of the Internet, social experience of teenagers expands and clashes with puberty of adolescents. Due to the comfort of cities, urbanization emerges and causes stress to adults because of artificial light, noise, pollution, violations of personal space, and family disruption...
June 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28396139/steroid-diabetes-before-puberty-a-diagnosis-to-confirm
#8
Emilio García García, Francisco de la Cerda Ojeda
No abstract text is available yet for this article.
July 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28364254/characterisation-of-rapid-progressors-to-type-1-diabetes-among-children-with-hla-conferred-disease-susceptibility
#9
Petra M Pöllänen, Johanna Lempainen, Antti-Pekka Laine, Jorma Toppari, Riitta Veijola, Paula Vähäsalo, Jorma Ilonen, Heli Siljander, Mikael Knip
AIMS/HYPOTHESIS: In this study, we aimed to characterise rapid progressors to type 1 diabetes among children recruited from the general population, on the basis of HLA-conferred disease susceptibility. METHODS: We monitored 7410 HLA-predisposed children participating in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study for the development of beta cell autoimmunity and type 1 diabetes from birth over a median follow-up time of 16.2 years (range 0...
March 31, 2017: Diabetologia
https://www.readbyqxmd.com/read/28347497/diabetes-and-ramadan-practical-guidelines
#10
REVIEW
Mohamed Hassanein, Monira Al-Arouj, Osama Hamdy, Wan Mohamad Wan Bebakar, Abdul Jabbar, Abdulrazzaq Al-Madani, Wasim Hanif, Nader Lessan, Abdul Basit, Khaled Tayeb, Mak Omar, Khalifa Abdallah, Abdulaziz Al Twaim, Mehmet Akif Buyukbese, Adel A El-Sayed, Abdullah Ben-Nakhi
Ramadan fasting is one of the five pillars of Islam and is compulsory for all healthy Muslims from puberty onwards. Exemptions exist for people with serious medical conditions, including many with diabetes, but a large number will participate, often against medical advice. Ensuring the optimal care of these patients during Ramadan is crucial. The International Diabetes Federation (IDF) and Diabetes and Ramadan (DAR) International Alliance have come together to deliver comprehensive guidelines on this subject...
April 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28324110/effects-of-metreleptin-in-pediatric-patients-with-lipodystrophy
#11
Rebecca J Brown, Cristina Adelia Meehan, Elaine Cochran, Kristina I Rother, David E Kleiner, Mary Walter, Phillip Gorden
Context: Lipodystrophy syndromes are rare disorders of deficient adipose tissue. Metreleptin, a human analog of leptin, improved metabolic abnormalities in mixed cohorts of children and adults with lipodystrophy and low leptin. Objective: Determine effects of metreleptin on diabetes, hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), growth, and puberty in pediatric patients with lipodystrophy and low leptin. Design: Prospective, single-arm, open-label studies with continuous enrollment since 2000...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28239958/differential-sex-effects-of-systolic-blood-pressure-and-low-density-lipoprotein-cholesterol-on-type-2-diabetes-life-course-data-from-the-bogalusa-heart-study
#12
Benjamin D Pollock, Wei Chen, Emily W Harville, Tian Shu, Vivian Fonseca, Franck Mauvais-Jarvis, Tanika N Kelly, Lydia A Bazzano
BACKGROUND: There may be sex-specific cardiometabolic mechanisms early in life that affect the development of type 2 diabetes mellitus (T2DM) through mid-adulthood. However, few studies have examined whether early life course interactions between cardiometabolic risk factors and sex are associated with incident T2DM. METHODS: This study followed 7725 children (3834 [49.6%] females, 3891 [50.4%] males) from the Bogalusa Heart Study through mid-adulthood to examine whether low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), or systolic blood pressure (SBP) differentially affect the risk of T2DM for females versus males...
February 27, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28179813/sex-differences-in-the-effects-of-androgens-acting-in-the-central-nervous-system-on-metabolism
#13
Jamie Morford, Franck Mauvais-Jarvis
One of the most sexually dimorphic aspects of metabolic regulation is the bidirectional modulation of glucose and energy homeostasis by testosterone in males and females. Testosterone deficiency predisposes men to metabolic dysfunction, with excess adiposity, insulin resistance, and type 2 diabetes, whereas androgen excess predisposes women to insulin resistance, adiposity, and type 2 diabetes. This review discusses how testosterone acts in the central nervous system, and especially the hypothalamus, to promote metabolic homeostasis or dysfunction in a sexually dimorphic manner...
December 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28168619/pure-endoscopic-management-of-epileptogenic-hypothalamic-hamartomas
#14
S Chibbaro, H Cebula, J Scholly, J Todeschi, I Ollivier, A Timofeev, M Ganau, P Di Emidio, M P Valenti, A M Staack, T Bast, B J Steinhoff, E Hirsch, P Kehrli, F Proust
Hypothalamic hamartomas (HH) are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Their usual clinical presentation is characterized by gelastic/dacrystic seizures which often become pharmaco-resistant and progress to secondary focal/generalized intractable epilepsy causing mostly in children cognitive and behavioral problems (particularly in cases of progressive epileptic encephalopathy) and precocious puberty. Whereas gelastic seizures can be surgically controlled either by resection of the lesion or disconnection (tissue-destructive) procedures, aimed at functionally prevent the spreading of the epileptic burst; generalized seizures tend to respond better to HH excision rather than isolated neocortical resections, which generally fail to control them...
February 7, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28112874/duration-of-puberty-in-preterm-girls
#15
L L Hui, H S Lam, G M Leung, C M Schooling
OBJECTIVES: Preterm birth is associated with altered pubertal timing, but the effect on pubertal duration has rarely been assessed. Here, we tested the hypothesis that preterm birth is associated with shorter duration of puberty among girls in Hong Kong where preterm birth has little social patterning. METHODS: In the population-representative Chinese birth cohort "Children of 1997", we used multivariable linear regression to assess the association of preterm status (≤36 completed gestational weeks, n = 170; term birth 37-42 gestational weeks, n = 3476) with duration of puberty, adjusted for parent's highest education, mother's place of birth, maternal smoking during pregnancy, gestational diabetes, preeclampsia, and mother's age of menarche...
July 8, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28093873/diagnostic-and-management-challenges-from-childhood-puberty-through-to-transition-in-severe-insulin-resistance-due-to-insulin-receptor-mutations
#16
Christina Wei, Christine P Burren
Two Caucasian girls, both of normal weight and body mass indices, were diagnosed with type A insulin resistance (IR) in childhood. Case 1 presented with premature adrenarche aged 7 years, then by age 12 years had hirsutism, acne, acanthosis nigricans, and asymptomatic diabetes. Subsequent investigation revealed raised adiponectin (15.3 mg/L) and heterozygous p.Pro1205Leu mutation in the INSR gene encoding the insulin receptor. She experienced postprandial hypoglycaemia on metformin; acarbose was trialled and discontinued aged 16 years, as she became normoglycaemic...
January 17, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28063503/does-oral-glutamine-improve-insulin-sensitivity-in-adolescents-with-type-1-diabetes
#17
Lournaris Torres-Santiago, Nelly Mauras, Jobayer Hossain, Arthur L Weltman, Dominique Darmaun
OBJECTIVE: The decline in insulin sensitivity (SI) associated with puberty increases the difficulty of achieving glycemic control in adolescents with type 1 diabetes (T1D). The aim of this study was to determine whether glutamine supplementation affects blood glucose by enhancing SI in adolescents with T1D. METHODS: Thirteen adolescents with T1D (HbA1C 8.2 ± 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28007778/longitudinal-trajectories-of-metabolic-control-from-childhood-to-young-adulthood-in-type-1-diabetes-from-a-large-german-austrian-registry-a-group-based-modeling-approach
#18
Anke Schwandt, Julia M Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W Holl
OBJECTIVE: Worsening of glycemic control in type 1 diabetes during puberty is a common observation. However, HbA1c remains stable or even improves for some youths. The aim is to identify distinct patterns of glycemic control in type 1 diabetes from childhood to young adulthood. RESEARCH DESIGN AND METHODS: A total of 6,433 patients with type 1 diabetes were selected from the prospective, multicenter diabetes patient registry Diabetes-Patienten-Verlaufsdokumentation (DPV) (follow-up from age 8 to 19 years, baseline diabetes duration ≥2 years, HbA1c aggregated per year of life)...
March 2017: Diabetes Care
https://www.readbyqxmd.com/read/27973749/banting-memorial-lecture-2016-reducing-lifetime-risk-of-complications-in-adolescents-with-type-1-diabetes
#19
REVIEW
D B Dunger
Adolescence is a challenging period of life for any young person, and for those with Type 1 diabetes, physiological and psychological factors can result in a deterioration in glycaemic control. In young people with Type 1 diabetes, puberty may be an additional risk factor impacting on the lifetime risk for renal and cardiovascular complications. Our longitudinal studies have identified that increases in urinary albumin excretion through childhood are associated with the development of microalbuminuria and a generalized endotheliopathy linked to cardiovascular risk...
April 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27922891/coexistence-of-adult-onset-eruptive-syringoma-and-bilateral-renal-cell-carcinoma-a-case-report
#20
Pinar Incel Uysal, Basak Yalcin, Esra Ozhamam, Onder Bozdogan
Eruptive syringoma is an unusual variant of syringoma, which usually presents before or during puberty. It typically occurs in large numbers as multiple yellow-brown-colored papules, which may show spontaneous regression. Because some authors have proposed that it could present as a reactive process of eccrine ducts to an inflammatory reaction caused by an unknown trigger, the exact pathomechanism is still unclear. There are also reports in the literature on the association of eruptive syringoma in Down syndrome, diabetes, milium, sarcoidosis, and psychiatric disorders...
January 2017: American Journal of Dermatopathology
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