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https://www.readbyqxmd.com/read/28222503/selenium-levels-in-serum-red-blood-cells-and-cerebrospinal-fluid-of-alzheimer-s-disease-patients-a-report-from-the-australian-imaging-biomarker-lifestyle-flagship-study-of-ageing-aibl
#1
Bárbara R Cardoso, Dominic J Hare, Ashley I Bush, Qiao-Xin Li, Christopher J Fowler, Colin L Masters, Ralph N Martins, Katherine Ganio, Amber Lothian, Soumya Mukherjee, Eugene A Kapp, Blaine R Roberts
Selenium (Se) protects cells against oxidative stress damage through a range of bioactive selenoproteins. Increased oxidative stress is a prominent feature of Alzheimer's disease (AD), and previous studies have shown that Se deficiency is associated with age-related cognitive decline. In this study, we assessed Se status in different biofluids from a subgroup of participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. As Se in humans can either be an active component of selenoproteins or inactive via non-specific incorporation into other proteins, we used both size exclusion chromatography-inductively coupled plasma-mass spectrometry (SEC-ICP-MS) and tandem mass spectrometry to characterize selenoproteins in serum...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222502/subclinical-doses-of-atp-sensitive-potassium-channel-modulators-prevent-alterations-in-memory-and-synaptic-alterations-in-memory-and-synaptic-%C3%AE
#2
Karla Salgado-Puga, Javier Rodríguez-Colorado, Roberto A Prado-Alcalá, Fernando Peña-Ortega
In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (KATP) are involved in neural function and plasticity. Moreover, alterations in KATP activity and expression have been observed in Alzheimer's disease (AD) and during amyloid-β (Aβ)-induced pathology. Thus, we tested whether KATP modulators can influence Aβ-induced deleterious effects on memory, hippocampal network function, and plasticity. We found that treating animals with subclinical doses (those that did not change glycemia) of a KATP blocker (Tolbutamide) or a KATP opener (Diazoxide) differentially restrained Aβ-induced memory deficit, hippocampal network activity inhibition, and long-term synaptic plasticity unbalance (i...
February 10, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222489/characterization-of-a-novel-signal-transducer-element-intrinsic-to-class-iiia-b-adenylate-cyclases-and-guanylate-cyclases
#3
Miriam Ziegler, Jens Bassler, Stephanie Beltz, Anita Schultz, Andrei N Lupas, Joachim E Schultz
Adenylate cyclases (ACs) are signalling proteins that produce the second messenger cAMP. Class III ACs comprises four groups (class IIIa-d); of these, class IIIa and IIIb ACs have been identified in bacteria and eukaryotes. Many class IIIa ACs are anchored to membranes via hexahelical domains. In eukaryotic ACs, membrane anchors are well conserved, suggesting that this region possesses important functional characteristics that are as yet unknown. To address this question, we replaced the hexahelical membrane anchor of the mycobacterial AC Rv1625c by the hexahelical quorum-sensing receptor from Legionella, LqsS...
February 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28222392/endor-with-band-selective-shaped-inversion-pulses
#4
Claudia E Tait, Stefan Stoll
Electron Nuclear DOuble Resonance (ENDOR) is based on the measurement of nuclear transition frequencies through detection of changes in the polarization of electron transitions. In Davies ENDOR, the initial polarization is generated by a selective microwave inversion pulse. The rectangular inversion pulses typically used are characterized by a relatively low selectivity, with full inversion achieved only for a limited number of spin packets with small resonance offsets. With the introduction of pulse shaping to EPR, the rectangular inversion pulses can be replaced with shaped pulses with increased selectivity...
February 12, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28222383/simultaneous-biogas-upgrading-and-centrate-treatment-in-an-outdoors-pilot-scale-high-rate-algal-pond
#5
Esther Posadas, David Marín, Saúl Blanco, Raquel Lebrero, Raúl Muñoz
The bioconversion of biogas to biomethane coupled to centrate treatment was evaluated in an outdoors pilot scale high rate algal pond interconnected to an external CO2-H2S absorption column (AC) via settled broth recirculation. CO2-removal efficiencies ranged from 50 to 95% depending on the alkalinity of the cultivation broth and environmental conditions, while a complete H2S removal was achieved regardless of the operational conditions. A maximum CH4 concentration of 94% with a limited O2 and N2 stripping was recorded in the upgraded biogas at recycling liquid/biogas ratios in the AC of 1 and 2...
February 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28222298/vascular-morphogenesis-an-integrin-and-fibronectin-highway
#6
Hellyeh Hamidi, Johanna Ivaska
A new study shows that endothelial cells use synaptic-like machinery to control polarized secretion and deposition of newly synthesised fibronectin. This process is coupled to active integrin recycling to the same locations and is fundamental for vascular development in zebrafish.
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28222265/modeling-soluble-and-particulate-lead-release-into-drinking-water-from-full-and-partially-replaced-lead-service-lines
#7
Ahmed A Abokifa, Pratim Biswas
Partial replacement of lead service lines (LSLs) often results in the excessive long-term release of lead particulates due to the disturbance of pipe scale and galvanic corrosion. In this study, a modeling approach to simulate the release and transport of particulate and dissolved lead from full and partially replaced LSLs is developed. A mass transfer model is coupled with a stochastic residential water demand generator to investigate the effect of normal household usage (NHU) flow patterns on lead exposure...
February 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28222260/the-k-channel-a-multi-functional-architecture-for-dynamically-re-configurable-sample-processing-in-droplet-microfluidics
#8
Steven R Doonan, Ryan C Bailey
By rapidly creating libraries of thousands of unique, miniaturized reactors, droplet microfluidics provides a powerful method for automating high-throughput chemical analysis. In order to engineer in-droplet assays, microfluidic devices must add reagents into droplets, remove fluid from droplets, and perform other necessary operations, each typically provided by a unique, specialized geometry. Unfortunately, modifying device performance or changing operations usually requires re-engineering the device among these specialized geometries, a time-consuming and costly process when optimizing in-droplet assays...
February 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28222234/transcriptome-analysis-of-the-brassica-napus-leptosphaeria-maculans-pathosystem-identifies-receptor-signalling-and-structural-genes-underlying-plant-resistance
#9
Michael G Becker, Xuehua Zhang, Philip L Walker, Joey C Wan, Jenna L Millar, Deirdre Khan, Matthew J Granger, Jacob D Cavers, Ainsley C Chan, Dilantha W G Fernando, Mark F Belmonte
The hemibiotrophic fungal pathogen Leptosphaeria maculans is the causal agent of blackleg disease in Brassica napus (canola, oilseed rape) and causes significant yield loss worldwide. While genetic resistance has been used to mitigate the disease using traditional breeding strategies, there is little knowledge about the genes contributing to blackleg resistance. RNA sequencing and a streamlined bioinformatics pipeline identified unique genes and plant defense pathways specific to plant resistance in the B. napus-L...
February 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28222198/algorithmic-design-of-a-noise-resistant-and-efficient-closed-loop-deep-brain-stimulation-system-a-computational-approach
#10
Sofia D Karamintziou, Ana Luísa Custódio, Brigitte Piallat, Mircea Polosan, Stéphan Chabardès, Pantelis G Stathis, George A Tagaris, Damianos E Sakas, Georgia E Polychronaki, George L Tsirogiannis, Olivier David, Konstantina S Nikita
Advances in the field of closed-loop neuromodulation call for analysis and modeling approaches capable of confronting challenges related to the complex neuronal response to stimulation and the presence of strong internal and measurement noise in neural recordings. Here we elaborate on the algorithmic aspects of a noise-resistant closed-loop subthalamic nucleus deep brain stimulation system for advanced Parkinson's disease and treatment-refractory obsessive-compulsive disorder, ensuring remarkable performance in terms of both efficiency and selectivity of stimulation, as well as in terms of computational speed...
2017: PloS One
https://www.readbyqxmd.com/read/28222194/forecasting-outpatient-visits-using-empirical-mode-decomposition-coupled-with-back-propagation-artificial-neural-networks-optimized-by-particle-swarm-optimization
#11
Daizheng Huang, Zhihui Wu
Accurately predicting the trend of outpatient visits by mathematical modeling can help policy makers manage hospitals effectively, reasonably organize schedules for human resources and finances, and appropriately distribute hospital material resources. In this study, a hybrid method based on empirical mode decomposition and back-propagation artificial neural networks optimized by particle swarm optimization is developed to forecast outpatient visits on the basis of monthly numbers. The data outpatient visits are retrieved from January 2005 to December 2013 and first obtained as the original time series...
2017: PloS One
https://www.readbyqxmd.com/read/28222140/in-situ-single-cell-detection-via-microfluidic-magnetic-bead-assay
#12
Fan Liu, Pawan Kc, Ge Zhang, Jiang Zhe
We present a single cell detection device based on magnetic bead assay and micro Coulter counters. This device consists of two successive micro Coulter counters, coupled with a high gradient magnetic field generated by an external magnet. The device can identify single cells in terms of the transit time difference of the cell through the two micro Coulter counters. Target cells are conjugated with magnetic beads via specific antibody and antigen binding. A target cell traveling through the two Coulter counters interacts with the magnetic field, and have a longer transit time at the 1st counter than that at the 2nd counter...
2017: PloS One
https://www.readbyqxmd.com/read/28222124/modelling-the-effects-of-environmental-conditions-on-the-acoustic-occurrence-and-behaviour-of-antarctic-blue-whales
#13
Fannie W Shabangu, Dawit Yemane, Kathleen M Stafford, Paul Ensor, Ken P Findlay
Harvested to perilously low numbers by commercial whaling during the past century, the large scale response of Antarctic blue whales Balaenoptera musculus intermedia to environmental variability is poorly understood. This study uses acoustic data collected from 586 sonobuoys deployed in the austral summers of 1997 through 2009, south of 38°S, coupled with visual observations of blue whales during the IWC SOWER line-transect surveys. The characteristic Z-call and D-call of Antarctic blue whales were detected using an automated detection template and visual verification method...
2017: PloS One
https://www.readbyqxmd.com/read/28222047/coherent-control-of-optical-absorption-and-the-energy-transfer-pathway-of-an-infrared-quantum-dot-hybridized-with-a-vo2-nanoparticle
#14
Ali Hatef, Naser Zamani, William Johnston
We systematically investigate the optical response of a semiconductor quantum dot (QD) hybridized with a vanadium dioxide nanoparticle (VO2NP) in the infrared (IR) region. The VO2NP features a semiconductor to metal phase change characteristic below and above a critical temperature that leads to an abrupt change in the particle's optical properties. This feature means that the QD-VO2NP hybrid system can support the coherent coupling of exciton-polaritons and exciton-plasmon polaritons in the semiconductor and metal phases of the VO2NP, respectively...
February 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28221999/coupling-effect-of-double-lungs-on-a-vcv-ventilator-with-automatic-secretion-clearance-function
#15
Yan Shi, Bolun Zhang, Maolin Cai, Weiqing Xu
For patients with mechanical ventilation, secretions in airway are harmful and sometimes even mortal, it's of great significance to clear secretion timely and efficiently. In this paper, a new secretion clearance method for VCV (volume-controlled ventilation) ventilator is put forward, and a secretion clearance system with a VCV ventilator and double lungs is designed. Furthermore, the mathematical model of the secretion clearance system is built and verified via experimental study. Finally, to illustrate the influence of key parameters of respiratory system and secretion clearance system on the secretion clearance characteristics, coupling effects of two lungs on VCV secretion clearance system are studied by an orthogonal experiment, it can be obtained that rise of tidal volume adds to efficiency of secretion clearance while effect of area, compliance and suction pressure on efficiency of secretion clearance needs further study...
February 16, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28221947/rapid-determination-of-trace-multiresidues-of-18-sulfonamides-in-chicken-eggs-using-a-modified-quechers-method-coupled-with-ultrahigh-performance-liquid-chromatography
#16
X U Xu, Yuan-Can Xiao, Feng-Zu Hu, Dan-Dan Geng
A modified QuEChERS method was used and an ultrahigh performance liquid chromatography (UHPLC) method was developed for the rapid determination of 18 kinds of sulfonamide residues in chicken eggs. Sample preparation and cleanup conditions were carefully evaluated, and factors such as the adsorbent type and adsorption condition were key parameters in improving the cleanup. The modified QuEChERS method removed matrix interferences, and the sensitivity of the method increased about 5% for recovery and efficiency of the method...
September 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28221797/acid-gas-adsorption-on-metal-organic-framework-nanosheets-as-a-model-of-an-all-surface-material
#17
Joshua D Howe, Yang Liu, Luis Flores, David A Dixon, David S Sholl
To establish a model of metal-organic framework (MOF) surfaces and build an understanding of surface-specific ligand adsorption phenomena in MOFs, we present a computational study exploring multiple models of a series of MOF-2 nanosheet materials, "M-BDCs", with M = Zn, Cu, and Co and BDC = benzene-1,4-dicarboxylate. We study and assess the appropriateness of a series of models ranging from small clusters (18 atoms) to fully periodic sheet models. We additionally study the interactions of these models with acid gases and energy-relevant small molecules (CO, CO2, H2O, SO2, NO2, and H2S)...
February 21, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28221795/strongly-phosphorescent-transition-metal-%C3%AF-complexes-of-boron-boron-triple-bonds
#18
Holger Braunschweig, Theresa Dellermann, Rian D Dewhurst, Benjamin Hupp, Thomas Kramer, James D Mattock, Jan Mies, Ashwini K Phukan, Andreas Steffen, Alfredo Vargas
Herein are reported the first complexes of compounds with boron-boron triple bonds to transition metals, in this case CuI. Three different compounds were isolated that differ in the number of copper atoms bound to the BB unit. Metallation of the B-B triple bonds causes lengthening of the B-B and B-CNHC bonds, as well as large upfield shifts of the 11B NMR signals, suggesting greater orbital interactions between the boron and transition metal atoms than those observed with recently published diboryne / alkali metal cation complexes...
February 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28221794/probing-chemical-bonding-and-electronic-structures-in-tho-by-anion-photoelectron-imaging-and-theoretical-calculations
#19
Yanli Li, Jinghan Zou, Xiao-Gen Xiong, Jing Su, Hua Xie, Zejie Fei, Zichao Tang, Hong-Tao Liu
Since the renewal of the research on thorium based molten salt reactor, there is growing demand and interest in enhancing the knowledge of thorium chemistry both experimentally and theoretically. Compared with uranium, few chemical studies of thorium have been reported up to the present. Here we report the vibrational resolved photoelectron imaging of thorium monoxide anion. The electron affinity of ThO is firstly reported to be 0.707 ± 0.020 eV. Vibrational frequencies of ThO molecule and its anion are determined from Franck-Condon simulation...
February 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28221790/synthesis-and-cytostatic-and-antiviral-profiling-of-thieno-fused-7-deazapurine-ribonucleosides
#20
Michal Tichý, Sabina Smoleń, Eva Tloušťová, Radek Pohl, Tomáš Oždian, Klára Hejtmánková, Barbora Lišková, Soňa Gurská, Petr Džubák, Marián Hajdúch, Michal Hocek
Two isomeric series of new thieno-fused 7-deazapurine ribonucleosides (derived from 4-substituted thieno[2',3':4,5]pyrrolo[2,3-d]pyrimidines and thieno[3',2':4,5]pyrrolo[2,3-d]pyrimidines) were synthesized by a sequence involving Negishi coupling of 4,6-dichloropyrimidine with iodothiophenes, nucleophilic azidation, cyclization of tetrazolopyrimidines, followed by glycosylation and cross-couplings or nucleophilic substitutions at position 4. Most nucleosides (from both isomeric series) exerted low micromolar or submicromolar in vitro cytostatic activities against a broad panel of cancer and leukemia cell lines and some antiviral activity against HCV...
February 21, 2017: Journal of Medicinal Chemistry
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