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https://www.readbyqxmd.com/read/28347132/radiolabeled-peptides-current-and-new-perspectives
#1
Marta Opalinska, Alicja Hubalewska-Dydejczyk, Anna Sowa-Staszczak
Radiolabeled peptides have been the subject of research for over 20 years and during that time possibility/variety of peptide receptor imaging and later targeted radiotherapy increased significantly. The targeted receptors belong to the large family of G-protein-coupled receptors or tyrosine kinases receptors partially connected with them. They both regulate large signaling networks, control multiple cell functions and are implicated in many diseases including cancers. The essential feature of peptides used in nuclear medicine involves their ability to binding with high affinity and specify to their receptors overexpressed on tumor cells...
June 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28347128/temperature-and-wavelength-dependence-of-energy-transfer-process-between-quantized-states-and-surface-states-in-cdse-quantum-dots
#2
Lei Zhang, Qinfeng Xu, Mingliang Liu, Lingbin Kong, Mengmeng Jiao, Haifeng Mu, Dehua Wang, Honggang Wang, Jiannong Chen, Chuanlu Yang
Temperature and wavelength dependence of energy transfer (ET) process between quantized states and surface trap states of CdSe quantum dots was investigated, respectively. The experimental results demonstrate that the photoluminescence (PL) intensity of the quantized states decreases with respect to the trap state emission, especially at lower temperatures. The observed ET process between quantized states and trap states which is influenced by the thermal population behavior. At the same temperature, the silver films can greatly enhance the energy transfer (ET) rate from the quantized states to trap states due to surface plasmonic coupling effect...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28346903/the-oceanus-statue-of-the-fontana-di-trevi-rome-the-analysis-of-black-crust-as-a-tool-to-investigate-the-urban-air-pollution-and-its-impact-on-the-stone-degradation
#3
Mauro F La Russa, Paola Fermo, Valeria Comite, Cristina M Belfiore, Donatella Barca, Annamaria Cerioni, Marina De Santis, Lorena Francesca Barbagallo, Michela Ricca, Silvestro A Ruffolo
This paper deals with the analysis of black crust coming from the statue of Oceanus belonging to the Fontana di Trevi (Rome). This monument is undoubtedly one of the main touristic attractions of Rome. During the restoration held between 2014 and 2015, some diagnostic analyses had been carried out. It has been highlighted that the sheltered surfaces suffer the formation of black crust, especially on the marble statues. The possibility to sample those degradation products, together with the unaltered substrate, represented an excellent opportunity to characterize the marble itself, to assess the impact of the urban air pollution on the stone material, and to detect the pollutant on a precise timescale...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346893/biochemical-transformation-of-lignin-for-deriving-valued-commodities-from-lignocellulose
#4
REVIEW
Daniel L Gall, John Ralph, Timothy J Donohue, Daniel R Noguera
The biochemical properties of lignin present major obstacles to deriving societally beneficial entities from lignocellulosic biomass, an abundant and renewable feedstock. Similar to other biopolymers such as polysaccharides, polypeptides, and ribonucleic acids, lignin polymers are derived from multiple types of monomeric units. However, lignin's renowned recalcitrance is largely attributable to its racemic nature and the variety of covalent inter-unit linkages through which its aromatic monomers are linked...
March 24, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/28346826/imaging-successive-intermediate-states-of-the-on-surface-ullmann-reaction-on-cu-111-role-of-the-metal-coordination
#5
Sören Zint, Daniel Ebeling, Tobias Schlöder, Sebastian Ahles, Doreen Mollenhauer, Hermann A Wegner, Andre Schirmeisen
The in-depth knowledge about on-surface reaction mechanisms is crucial for the tailor-made design of covalently bonded organic frameworks, for applications such as nanoelectronic or -optical devices. Latest developments in atomic force microscopy, which rely on functionalizing the tip with single CO molecules at low temperatures allow to image molecular systems with submolecular resolution. Here, we are using this technique to study the complete reaction pathway of the on-surface Ullmann-type coupling between bromotriphenylene molecules on a Cu(111) surface...
March 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28346820/blastomyces-dermatitidis-serine-protease-dipeptidyl-peptidase-iva-dppiva-cleaves-elr-cxc-chemokines-altering-their-effects-on-neutrophils
#6
Jenna Lorenzini, J Scott Fites, Jeniel Nett, Bruce S Klein
Blastomycosis elicits a pyogranulomatous inflammatory response, which involves a prominent recruitment of neutrophils to the site of infection. While neutrophils are efficiently recruited to the site of infection, this event is paradoxically coupled with the host's inability to control infection by Blastomyces dermatitidis, the causative agent. The mechanisms underlying this characteristic pyogranulomatous response and inability of neutrophils to kill the yeast are poorly understood. We recently reported that the fungal protease DppIVA promotes B...
March 27, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28346780/high-spin-polymers-ferromagnetic-coupling-of-s-1-hexaazacyclophane-units-up-to-a-pure-s-2-polycyclophane
#7
Lukasz Skorka, Piotr Kurzep, Timothée Chauviré, Lionel Dubois, Jean-Marie Mouesca, Vincent Maurel, Irena Kulszewicz-Bajer
Triarylamines oxidized to radical cations can be used as stable spins sources for the design of high-spin compounds. Here, we present the synthesis of the polyarylamine containing hexaazacyclophanes linked via meta-terphenyl bridges. Spins, created after the oxidation of the polymer, can be coupled magnetically in cyclophane moieties via meta-phenyl and along the polymer chain via meta-terphenyl units. The formation of quintet spin state was evidenced by pulsed-EPR nutation spectroscopy. Two exchange coupling constants via both couplers were determined experimentally and corresponded to J/k = 89 K in cyclophane moiety and j/k = 17 K via meta-terphenyl...
March 27, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28346775/hyperinsulinism-causing-mutations-cause-multiple-molecular-defects-in-sur1-nbd1
#8
Claudia Paola Alvarez, Marijana Stagljar, D Ranjith Muhandiram, Voula Kanelis
The sulfonylurea receptor 1 (SUR1) protein forms the regulatory subunit in ATP sensitive K+ (KATP) channels in the pancreas. SUR proteins are members of the ATP-binding cassette (ABC) superfamily of proteins. Binding and hydrolysis of MgATP at the SUR nucleotide binding domains (NBDs) lead to channel opening. Pancreatic KATP channels play an important role in insulin secretion. SUR1 mutations that result in increased channel opening ultimately inhibit insulin secretion and lead to neonatal diabetes. In contrast, SUR1 mutations that disrupt trafficking and/or decrease gating of KATP channels cause congenital hyperinsulinism, where over secretion of insulin occurs even in the presence of low glucose...
March 27, 2017: Biochemistry
https://www.readbyqxmd.com/read/28346742/leaf-economic-and-hydraulic-divergences-underpin-ecological-differentiation-in-the-bromeliaceae
#9
Jamie Males, Howard Griffiths
Leaf economic and hydraulic theory have rarely been applied to the ecological differentiation of speciose herbaceous plant radiations. The role of character trait divergences and network reorganisation in the differentiation of the functional types in the megadiverse Neotropical Bromeliaceae was explored by quantifying a range of leaf economic and hydraulic traits in 50 diverse species. Functional types, which are defined by combinations of C3 or CAM photosynthesis, terrestrial or epiphytic habits, and non-specialised, tank-forming or atmospheric morphologies, segregated clearly in trait space...
March 27, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28346735/carbenes-as-electron-pair-donors-for-p%C3%A2-c-pnicogen-bonds
#10
Janet E Del Bene, Ibon Alkorta, Jose Elguero
Ab initio MP2/aug'-cc-pVTZ calculations have been performed on the P…C pnicogen-bonded complexes of the singlet carbene molecules C(NH2)2, C(OH)2, and cyclic C(OCH)2 [OHC] with the molecules H2XP for X = F, Cl, NC, OH, CH3, CN, CCH, and H. H2XP:C(NH2)2 and H2XP:C(OH)2 complexes have Cs symmetry and two different structures: one in which the symmetry plane of the complex and the local symmetry plane of the carbene are non-coplanar, and the other in which they are coplanar. The non-coplanar H2XP:C(NH2)2 and H2XP:C(OH)2 complexes arise only when X is one of the more electronegative substituents...
March 27, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28346689/peripheral-and-central-fatigue-after-high-intensity-resistance-circuit-training
#11
Gonzalo Márquez, Salvador Romero-Arenas, Cristian Marín-Pagán, Antonio Vera-Ibañez, Miguel FernáNdez Del Olmo, Wolfgang Taube
INTRODUCTION: The aim of this study was to investigate the effects of high intensity resistance circuit (HIRC) and traditional strength training (TST) on neuromuscular fatigue and metabolic responses. METHODS: Twelve trained young subjects performed HIRC and TST in a counterbalanced order with 1 week rest in-between. The amount of workload and the inter-set time for each local muscle group were matched (180 s), however, the time between successive exercises differed...
March 27, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28346515/gender-differences-in-reward-and-punishment-for-monetary-and-social-feedback-in-children-an-erp-study
#12
Ying Ding, Encong Wang, Yuchen Zou, Yan Song, Xue Xiao, Wanyi Huang, Yanfang Li
Gender differences in feedback processing have been observed among adolescents and adults through event-related potentials. However, information on whether and how this feedback processing is affected by feedback valence, feedback type, and individual sensitivity in reward/punishment among children remains minimal. In this study, we used a guessing game task coupled with electroencephalography to investigate gender differences in feedback processing, in which feedback to reward and punishment was presented in the context of monetary and social conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28346437/friction-forces-position-the-neural-anlage
#13
Michael Smutny, Zsuzsa Ákos, Silvia Grigolon, Shayan Shamipour, Verena Ruprecht, Daniel Čapek, Martin Behrndt, Ekaterina Papusheva, Masazumi Tada, Björn Hof, Tamás Vicsek, Guillaume Salbreux, Carl-Philipp Heisenberg
During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage...
March 27, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28346404/chemical-screening-identifies-atm-as-a-target-for-alleviating-senescence
#14
Hyun Tae Kang, Joon Tae Park, Kobong Choi, Yongsub Kim, Hyo Jei Claudia Choi, Chul Won Jung, Young-Sam Lee, Sang Chul Park
Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and age-related diseases. Here, we performed high-throughput screening to identify compounds that alleviate senescence and identified the ataxia telangiectasia mutated (ATM) inhibitor KU-60019 as an effective agent. To elucidate the mechanism underlying ATM's role in senescence, we performed a yeast two-hybrid screen and found that ATM interacted with the vacuolar ATPase V1 subunits ATP6V1E1 and ATP6V1G1. Specifically, ATM decreased E-G dimerization through direct phosphorylation of ATP6V1G1...
March 27, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28346372/-bligh-and-dyer-and-folch-methods-for-solid-liquid-liquid-extraction-of-lipids-from-microorganisms-comprehension-of-solvatation-mechanisms-and-towards-substitution-with-alternative-solvents
#15
Cassandra Breil, Maryline Abert Vian, Thomas Zemb, Werner Kunz, Farid Chemat
Bligh and Dyer (B & D) or Folch procedures for the extraction and separation of lipids from microorganisms and biological tissues using chloroform/methanol/water have been used tens of thousands of times and are "gold standards" for the analysis of extracted lipids. Based on the Conductor-like Screening MOdel for realistic Solvatation (COSMO-RS), we select ethanol and ethyl acetate as being potentially suitable for the substitution of methanol and chloroform. We confirm this by performing solid-liquid extraction of yeast (Yarrowia lipolytica IFP29) and subsequent liquid-liquid partition-the two steps of routine extraction...
March 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28346346/an-effective-terrain-aided-navigation-for-low-cost-autonomous-underwater-vehicles
#16
Ling Zhou, Xianghong Cheng, Yixian Zhu, Chenxi Dai, Jinbo Fu
Terrain-aided navigation is a potentially powerful solution for obtaining submerged position fixes for autonomous underwater vehicles. The application of terrain-aided navigation with high-accuracy inertial navigation systems has demonstrated meter-level navigation accuracy in sea trials. However, available sensors may be limited depending on the type of the mission. Such limitations, especially for low-grade navigation sensors, not only degrade the accuracy of traditional navigation systems, but further impact the ability to successfully employ terrain-aided navigation...
March 25, 2017: Sensors
https://www.readbyqxmd.com/read/28346258/management-of-metastatic-breast-carcinoma-of-iris-with-intraocular-bevacizumab-injections
#17
G Ece Akinci, Ahmet M Hondur, Tongalp H Tezel
PURPOSE: To describe intraocular use of bevacizumab for a metastatic breast carcinoma of the iris resistant to advanced systemic chemotherapy protocols, for which conventional treatment would be local radiotherapy or brachytherapy. METHODS: Case report. RESULTS: A 65-year-old woman, who was previously diagnosed with breast carcinoma and treated with radical mastectomy coupled with radiotherapy and chemotherapy, presented with an iris mass in her left eye...
March 24, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28346211/stability-of-two-antifungal-agents-fluconazole-and-miconazole-compounded-in-humco-recura-topical-cream-to-determine-beyond-use-date
#18
Pradeep Gautam, Bob Light, Troy Purvis
A novel compounding vehicle (RECURA) has previously been proven to penetrate the nail bed when compounded with the antifungal agent miconazole or fluconazole, providing for an effective treatment for onychomycosis. In this study, miconazole and fluconazole were compounded separately in RECURA compounding cream, and they were tested at different time points (0, 7, 14, 28, 45, 60, 90, and 180 days) to determine the beyond-use date of those formulations. The beyond-use date testing of both formulations (10% miconazole in RECURA and 10% fluconazole in RECURA) proved them to be physically, chemically, and microbiologically stable under International Conference of Harmonisation controlled room temperature (25°C ± 2°C/60% RH ±5%) for at least 180 days from the date of compounding...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346163/sleep-and-mental-health-the-moderating-role-of-perceived-adolescent-parent-attachment
#19
Kelly M Tu, Brian T Marks, Mona El-Sheikh
OBJECTIVE: The present study investigated whether the effects of sleep duration and quality on adolescent adjustment were moderated by perceived attachment to mothers and fathers. DESIGN: The study used a cross-sectional design. SETTING: Participants were recruited from small town and semirural communities in Alabama. PARTICIPANTS: Participants were 106 adolescents (mean age=13.61 years, SD=.73; 55% girls; 28% African American, 72% European American) and their parents...
April 2017: Sleep Health
https://www.readbyqxmd.com/read/28346122/non-targeted-metabolomics-in-sport-and-exercise-science
#20
Liam M Heaney, Kevin Deighton, Toru Suzuki
Metabolomics incorporates the study of metabolites that are produced and released through physiological processes at both the systemic and cellular levels. Biological compounds at the metabolite level are of paramount interest in the sport and exercise sciences, although research in this field has rarely been referred to with the global 'omics terminology. Commonly studied metabolites in exercise science are notably within cellular pathways for adenosine triphosphate production such as glycolysis (e.g., pyruvate and lactate), β-oxidation of free fatty acids (e...
March 27, 2017: Journal of Sports Sciences
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