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https://www.readbyqxmd.com/read/28937515/laparoscopic-major-vascular-injury-simulation-using-a-synthetic-compared-with-porcine-model
#1
Magdy P Milad, Farah A Alvi, Michael T Breen, Cynthia Brincat, Peter J Frederick, Christina Lewicky-Gaupp, Mark Lewis, Bryan Rone, Kimberly Swan, Karin Wollschlaeger
BACKGROUND: Major vascular injury training may improve clinical skills and reduce patient morbidity during gynecologic laparoscopy; thus, reliable models for simulation should be identified. METHOD: Two laparoscopic major vascular injury simulations using synthetic or live porcine models were constructed. The primary surgeon was given the opportunity to complete both simulations. After obtaining peritoneal access, the surgeon quickly encountered a major vascular injury...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28932487/intra-articular-fractures-of-the-distal-tibia-current-concepts-of-management
#2
REVIEW
Alexandre Sitnik, Aleksander Beletsky, Steven Schelkun
Results of the treatment of intra-articular fractures of the distal tibia have improved significantly during the last two decades.Recognition of the role of soft tissues has led to the development of a staged treatment strategy. At the first stage, joint-bridging external fixation and fibular fixation are performed. This leads to partial reduction of the distal tibial fracture and allows time for the healing of soft tissues and detailed surgical planning.Definitive open reduction and internal fixation of the tibial fracture is performed at a second stage, when the condition of the soft tissues is safe...
August 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28922990/streamlined-system-for-conducting-in-vitro-studies-using-decellularized-kidney-scaffolds
#3
Andrew Reyes Padalhin, Chanmi Park, Byong-Taek Lee
Kidney regeneration is a complex process that can only be studied in vitro at a limited capacity due to the inherent structural and functional complexity of its tissues. Thus, a suitable platform for conducting cellular response and development should be established from decellularized tissues with intact microarchitecture. In this study, a modular streamlined system was developed to allow manageable handling and set-up of in vitro studies using decellularized rat kidneys. The system is composed of commercially available parts that can be reused, interchanged, and re-configured based on the desired experimental stage and process...
September 19, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28914699/ergonomics-in-surgery-a-review
#4
Tatiana Catanzarite, Jasmine Tan-Kim, Emily L Whitcomb, Shawn Menefee
OBJECTIVE: Work-related musculoskeletal disorders (WMSDs) are prevalent among surgeons and may result in practice modification. We aimed to perform a comprehensive review of the English-language literature regarding ergonomic risk, prevalence of WMSDs, and unique ergonomic considerations by route of surgery. METHODS: Multiple searches were performed of PubMed and University library resources to access English-language publications related to surgeon ergonomics. Combinations of keywords were used for each mode of surgery, including the following: "ergonomics," "guidelines," "injury," "operating room," "safety," "surgeon," and "work-related musculoskeletal disorders...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28911177/deoxycorticosterone-salt-mediated-cardiac-inflammation-and-fibrosis-are-dependent-on-functional-clock-signaling-in-male-mice
#5
Elizabeth K Fletcher, James Morgan, David R Kennaway, Laura A Bienvenu, Amanda J Rickard, Lea M D Delbridge, Peter J Fuller, Colin D Clyne, Morag J Young
Activation of the mineralocorticoid receptor (MR) promotes inflammation, fibrosis, and hypertension. Clinical and experimental studies show that MR antagonists have significant therapeutic benefit for all-cause heart failure; however, blockade of renal MRs limits their widespread use. Identification of key downstream signaling mechanisms for the MR in the cardiovascular system may enable development of targeted MR antagonists with selectivity for pathological MR signaling and lower impact on physiological renal electrolyte handling...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28903499/the-long-lasting-rodenticide-brodifacoum-induces-neuropathology-in-adult-male-rats
#6
Sergey Kalinin, Natalia Marangoni, Katarzyna Kowal, Arunangsu Dey, Kinga Lis, Sergey Brodsky, Richard van Breemen, Zane Hauck, Richard Ripper, Israel Rubinstein, Guy Weinberg, Douglas L Feinstein
Superwarfarins are very long-lasting rodenticides effective in warfarin-resistant rodents at extremely low doses. The consequences of chronic superwarfarin levels in tissues, due to biological half-lives on the order of 20 days, have not been examined. We now characterized the neurological effects of brodifacoum (BDF), one of the most widely used superwarfarins, in adult male Sprague Dawley rats. Dosing curves established the acute oral lethal dose for BDF as 221 ± 14 μg/kg. Measurement of tissue BDF levels showed accumulation throughout the body, including the central nervous system, with levels diminishing over several days...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28901617/dual-rotation-c-arm-cone-beam-computed-tomography-to-increase-low-contrast-detection
#7
Aymeric Reshef, Cyril Riddell, Yves Trousset, Saïd Ladjal, Isabelle Bloch
PURPOSE: This paper investigates the capabilities of a dual-rotation C-arm cone-beam computed tomography (CBCT) framework to improve non-contrast-enhanced low-contrast detection for full volume or volume-of-interest (VOI) brain imaging. METHOD: The idea is to associate two C-arm short-scan rotational acquisitions (spins): one over the full detector field of view (FOV) at low dose, and one collimated to deliver a higher dose to the central densest parts of the head...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28900923/tissue-specificity-soce-implications-for-ca-2-handling-in-endothelial-cells
#8
Lothar A Blatter
Many cellular functions of the vascular endothelium are regulated by fine-tuned global and local, microdomain-confined changes of cytosolic free Ca(2+) ([Ca(2+)]i). Vasoactive agonist-induced stimulation of vascular endothelial cells (VECs) typically induces Ca(2+) release through IP3 receptor Ca(2+) release channels embedded in the membrane of the endoplasmic reticulum (ER) Ca(2+) store, followed by Ca(2+) entry from the extracellular space elicited by Ca(2+) store depletion and referred to as capacitative or store-operated Ca(2+) entry (SOCE)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28900075/-circulating-micrornas-in-the-identification-of-biological-fluids-a-new-approach-to-standardization-of-expression-based-diagnostics
#9
A S Bavykin
Molecular profiling of normal tissues is a regular and necessary step when developing systems for expression analyses in biological samples, including diagnostic panels for various diseases and conditions. Yet there are still no rigorous criteria to allow precise typing of normal tissues. A main problem is that the methods employed in diagnostic expression testing are difficult to standardize. While various technologies, instruments, and reagents are available, universal protocols of handling biological material are lacking, thus impairing the reproducibility of data from independent studies...
July 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28898189/ct-texture-analysis-definitions-applications-biologic-correlates-and-challenges
#10
Meghan G Lubner, Andrew D Smith, Kumar Sandrasegaran, Dushyant V Sahani, Perry J Pickhardt
This review discusses potential oncologic and nononcologic applications of CT texture analysis ( CTTA CT texture analysis ), an emerging area of "radiomics" that extracts, analyzes, and interprets quantitative imaging features. CTTA CT texture analysis allows objective assessment of lesion and organ heterogeneity beyond what is possible with subjective visual interpretation and may reflect information about the tissue microenvironment. CTTA CT texture analysis has shown promise in lesion characterization, such as differentiating benign from malignant or more biologically aggressive lesions...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28893028/synovial-sarcoma-of-palmar-aspect-of-hand-and-survival-a-rare-case-report
#11
Tapan Kumar Sahoo, Ipsita Dhal, Saroj Kumar Das, Saroj Kumar Das Majumdar, Dillip Kumar Parida
Synovial sarcomas of the hand are extremely rare entities than most soft tissue sarcomas. The location at finger is further rarer than carpus of the hand. Synovial sarcoma of the hand/finger initially confused with many diagnoses such as myositis, haematoma, synovitis, tendonitis, bursitis, and other inflammatory lesions and therefore needs careful handling of the case with proper evaluation. We report a case of synovial sarcoma of the palmar surface of the right hand at interface of thumb and index finger in a 22-year-old female...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28890894/risk-of-contamination-of-gametes-and-embryos-during-cryopreservation-and-measures-to-prevent-cross-contamination
#12
REVIEW
Daniel C Joaquim, Eduardo D Borges, Iara G R Viana, Paula A Navarro, Alessandra A Vireque
The introduction and widespread application of vitrification are one of the most important achievements in human assisted reproduction techniques (ART) of the past decade despite controversy and unclarified issues, mostly related to concerns about disease transmission. Guidance documents published by US Food and Drug Administration, which focused on the safety of tissue/organ donations during Zika virus spread in 2016, as well as some reports of virus, bacteria, and fungi survival to cryogenic temperatures, highlighted the need for a review of the way how potentially infectious material is handled and stored in ART-related procedures...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28888007/nano%C3%A2-calcium-phosphate-bone-cement-based-on-si-stabilized-%C3%AE-tricalcium-phosphate-with-improved-mechanical-properties
#13
M Roozbahani, M Alehosseini, M Kharaziha, R Emadi
This study aimed to develop nano‑calcium phosphate cement (nCPC) and evaluate the effect of nanosized precursors on mechanical, physical and handling properties (injectability and setting time) as well as conversion rate of nano-reactants into nano-hydroxyapatite (nHA). In this study, while alpha tricalcium phosphate (α-TCP, 98wt%) and HA (2wt%) were applied as the powder phase, 2.5wt% NaH2PO4 solution was used as liquid phase of cement. Before nano-CPC preparation, Si-stabilized α-TCP nanopowder with particle size of 10±3...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28885822/three-dimensional-cell-culture-and-drug-testing-in-a-microfluidic-sidewall-attached-droplet-array
#14
Shi-Ping Zhao, Yan Ma, Qi Lou, Hong Zhu, Bo Yang, Qun Fang
Three-dimensional (3D) cell culture provides an effective way over conventional two-dimensional (2D) monolayer culture to more closely imitate the complex cellular organization, heterogeneity, and interactions as well as tissue microenvironments in vivo. Here we present a novel droplet-based 3D cell culture method by using droplet array attached on the sidewall of a PDMS piece. Such an arrangement not only avoids cells from adhering on the chip surface for achieving 3D cell culture in nanoliter-scale droplets, but also facilitates performing multiple operations to cells in droplets, including cell suspension droplet generation, drug treatment, and cell staining with a capillary-based liquid handling system, as well as in situ observation and direct scanning with a confocal laser scanning microscope...
September 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28885509/modeling-surgical-technical-skill-using-expert-assessment-for-automated-computer-rating
#15
David P Azari, Lane L Frasier, Sudha R Pavuluri Quamme, Caprice C Greenberg, Carla M Pugh, Jacob A Greenberg, Robert G Radwin
OBJECTIVE: Computer vision was used to predict expert performance ratings from surgeon hand motions for tying and suturing tasks. SUMMARY BACKGROUND DATA: Existing methods, including the objective structured assessment of technical skills (OSATS), have proven reliable, but do not readily discriminate at the task level. Computer vision may be used for evaluating distinct task performance throughout an operation. METHODS: Open surgeries was videoed and surgeon hands were tracked without using sensors or markers...
September 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28884732/-the-rehabilitative-treatment-of-the-patients-presenting-with-chronic-obstructive-pulmonary-disease-including-the-application-of-the-manual-handling-methods
#16
N S Ayrapetova, M A Eremushkin, I V Antonovich, O F Kuznetsov, A E Samorukov, S P Budylin, L Yu Tarasova, N A Derevnina
AIM: The objective of the present study was to identify the peculiar features and advantages of different methods for the mechanical impact on the thoracic tissues of the patients presenting with chronic obstructive pulmonary disease (COPD) and to develop specific indications for their clinical applications. MATERIAL AND METHODS: This randomized prospective comparative study included 137 patients with COPD. In accordance with the currently accepted classification (GOLD, 2013), all the patients had COPD of medium severity...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28883434/automated-video-mosaicking-approach-for-confocal-microscopic-imaging-in-vivo-an-approach-to-address-challenges-in-imaging-living-tissue-and-extend-field-of-view
#17
Kivanc Kose, Mengran Gou, Oriol Yélamos, Miguel Cordova, Anthony M Rossi, Kishwer S Nehal, Eileen S Flores, Octavia Camps, Jennifer G Dy, Dana H Brooks, Milind Rajadhyaksha
We describe a computer vision-based mosaicking method for in vivo videos of reflectance confocal microscopy (RCM). RCM is a microscopic imaging technique, which enables the users to rapidly examine tissue in vivo. Providing resolution at cellular-level morphology, RCM imaging combined with mosaicking has shown to be highly sensitive and specific for non-invasively guiding skin cancer diagnosis. However, current RCM mosaicking techniques with existing microscopes have been limited to two-dimensional sequences of individual still images, acquired in a highly controlled manner, and along a specific predefined raster path, covering a limited area...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882962/prospective-analysis-of-a-sterile-semi-automated-tissue-biopsy-homogenization-method-in-the-diagnosis-of-prosthetic-joint-infections
#18
Christian Suren, Norbert Harrasser, Florian Pohlig, Ingo J Banke, Ulrich Lenze, Florian Lenze, Carolin Knebel, Rüdiger VON Eisenhart-Rothe, Johannes Schauwecker, Heinrich M L Mühlhofer
BACKGROUND/AIM: Prosthetic joint infection (PJI) remains a serious complication of total joint arthroplasty. To effectively treat PJI, it is essential to identify the microorganism causing it and be able to combine correct surgical and anti-infective treatments. This cannot always be achieved with the currently employed diagnostic methods. The aim of this study was to evaluate a semi-automated tissue biopsy bead milling method (Ultra-TurrAX, Axonlab AG; Reichenbach, Germany) based on the hypothesis that the results are more sensitive for microbe detection and less prone to contamination...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28879089/pathology-clinical-signs-and-tissue-distribution-of-toxoplasma-gondii-in-experimentally-infected-reindeer-rangifer-tarandus
#19
Émilie Bouchard, Rajnish Sharma, Nicholas Bachand, Alvin A Gajadhar, Emily J Jenkins
Toxoplasma gondii is a zoonotic parasite found in vertebrates worldwide for which felids serve as definitive hosts. Despite low densities of felids in northern Canada, Inuit people in some regions show unexpectedly high levels of exposure, possibly through handling and consumption of Arctic wildlife. Free-ranging caribou (Rangifer tarandus) are widely harvested for food across the Canadian North, show evidence of seroexposure to T. gondii, and are currently declining in numbers throughout the Arctic. We experimentally infected three captive reindeer (conspecific with caribou) with 1000, 5000 or 10,000 oocysts of T...
December 2017: International Journal for Parasitology. Parasites and Wildlife
https://www.readbyqxmd.com/read/28878137/cf-airway-smooth-muscle-transcriptome-reveals-a-role-for-pyk2
#20
Daniel P Cook, Ryan J Adam, Keyan Zarei, Benjamin Deonovic, Mallory R Stroik, Nicholas D Gansemer, David K Meyerholz, Kin Fai Au, David A Stoltz
Abnormal airway smooth muscle function can contribute to cystic fibrosis (CF) airway disease. We previously found that airway smooth muscle from newborn CF pigs had increased basal tone, an increased bronchodilator response, and abnormal calcium handling. Since CF pigs lack airway infection and inflammation at birth, these findings suggest intrinsic airway smooth muscle dysfunction in CF. In this study, we tested the hypothesis that CFTR loss in airway smooth muscle would produce a distinct set of changes in the airway smooth muscle transcriptome that we could use to develop novel therapeutic targets...
September 7, 2017: JCI Insight
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