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Sally Adel

Soad Ali Yehia, Sally Adel Abdel-Halim, Mary Yosry Aziz
The objective of this study is to formulate biodegradable in situ microparticles (ISM) containing lornoxicam for post-operative and arthritic pain management. ISM emulsions were prepared according to 2(5) full factorial experimental design to investigate the influence of formulation variables on the release profile of the drug. The independent variables studied are the polymer type, polymer inherent viscosity, polymer concentration, oil type and polymer:oil ratio. In vitro drug release, microscopical examination, particle size determination and syringeability measurement were selected as dependent variables...
October 21, 2016: Drug Development and Industrial Pharmacy
Wahedul Karim Ansari, Md Shafiullah Parvej, Mohamed E El Zowalaty, Sally Jackson, Stephen A Bustin, Adel K Ibrahim, Ahmed E El Zowalaty, Md Tanvir Rahman, Han Zhang, Mohammad Ferdousur Rahman Khan, Md Mostakin Ahamed, Md Fasiur Rahman, Marzia Rahman, K H M Nazmul Hussain Nazir, Sultan Ahmed, Md Liakot Hossen, Md Abdul Kafi, Mat Yamage, Nitish C Debnath, Graba Ahmed, Hossam M Ashour, Md Masudur Rahman, Ayman Noreddin, Md Bahanur Rahman
Avian influenza viruses (AIVs) continue to pose a global threat. Waterfowl are the main reservoir and are responsible for the spillover of AIVs to other hosts. This study was conducted as part of routine surveillance activities in Bangladesh and it reports on the serological and molecular detection of H5N1 AIV subtype. A total of 2169 cloacal and 2191 oropharyngeal swabs as well as 1725 sera samples were collected from live birds including duck and chicken in different locations in Bangladesh between the years of 2013 and 2014...
September 25, 2016: Veterinary Microbiology
Wesley C Van Voorhis, John H Adams, Roberto Adelfio, Vida Ahyong, Myles H Akabas, Pietro Alano, Aintzane Alday, Yesmalie Alemán Resto, Aishah Alsibaee, Ainhoa Alzualde, Katherine T Andrews, Simon V Avery, Vicky M Avery, Lawrence Ayong, Mark Baker, Stephen Baker, Choukri Ben Mamoun, Sangeeta Bhatia, Quentin Bickle, Lotfi Bounaadja, Tana Bowling, Jürgen Bosch, Lauren E Boucher, Fabrice F Boyom, Jose Brea, Marian Brennan, Audrey Burton, Conor R Caffrey, Grazia Camarda, Manuela Carrasquilla, Dee Carter, Maria Belen Cassera, Ken Chih-Chien Cheng, Worathad Chindaudomsate, Anthony Chubb, Beatrice L Colon, Daisy D Colón-López, Yolanda Corbett, Gregory J Crowther, Noemi Cowan, Sarah D'Alessandro, Na Le Dang, Michael Delves, Joseph L DeRisi, Alan Y Du, Sandra Duffy, Shimaa Abd El-Salam El-Sayed, Michael T Ferdig, José A Fernández Robledo, David A Fidock, Isabelle Florent, Patrick V T Fokou, Ani Galstian, Francisco Javier Gamo, Suzanne Gokool, Ben Gold, Todd Golub, Gregory M Goldgof, Rajarshi Guha, W Armand Guiguemde, Nil Gural, R Kiplin Guy, Michael A E Hansen, Kirsten K Hanson, Andrew Hemphill, Rob Hooft van Huijsduijnen, Takaaki Horii, Paul Horrocks, Tyler B Hughes, Christopher Huston, Ikuo Igarashi, Katrin Ingram-Sieber, Maurice A Itoe, Ajit Jadhav, Amornrat Naranuntarat Jensen, Laran T Jensen, Rays H Y Jiang, Annette Kaiser, Jennifer Keiser, Thomas Ketas, Sebastien Kicka, Sunyoung Kim, Kiaran Kirk, Vidya P Kumar, Dennis E Kyle, Maria Jose Lafuente, Scott Landfear, Nathan Lee, Sukjun Lee, Adele M Lehane, Fengwu Li, David Little, Liqiong Liu, Manuel Llinás, Maria I Loza, Aristea Lubar, Leonardo Lucantoni, Isabelle Lucet, Louis Maes, Dalu Mancama, Nuha R Mansour, Sandra March, Sheena McGowan, Iset Medina Vera, Stephan Meister, Luke Mercer, Jordi Mestres, Alvine N Mfopa, Raj N Misra, Seunghyun Moon, John P Moore, Francielly Morais Rodrigues da Costa, Joachim Müller, Arantza Muriana, Stephen Nakazawa Hewitt, Bakela Nare, Carl Nathan, Nathalie Narraidoo, Sujeevi Nawaratna, Kayode K Ojo, Diana Ortiz, Gordana Panic, George Papadatos, Silvia Parapini, Kailash Patra, Ngoc Pham, Sarah Prats, David M Plouffe, Sally-Ann Poulsen, Anupam Pradhan, Celia Quevedo, Ronald J Quinn, Christopher A Rice, Mohamed Abdo Rizk, Andrea Ruecker, Robert St Onge, Rafaela Salgado Ferreira, Jasmeet Samra, Natalie G Robinett, Ulrich Schlecht, Marjorie Schmitt, Filipe Silva Villela, Francesco Silvestrini, Robert Sinden, Dennis A Smith, Thierry Soldati, Andreas Spitzmüller, Serge Maximilian Stamm, David J Sullivan, William Sullivan, Sundari Suresh, Brian M Suzuki, Yo Suzuki, S Joshua Swamidass, Donatella Taramelli, Lauve R Y Tchokouaha, Anjo Theron, David Thomas, Kathryn F Tonissen, Simon Townson, Abhai K Tripathi, Valentin Trofimov, Kenneth O Udenze, Imran Ullah, Cindy Vallieres, Edgar Vigil, Joseph M Vinetz, Phat Voong Vinh, Hoan Vu, Nao-Aki Watanabe, Kate Weatherby, Pamela M White, Andrew F Wilks, Elizabeth A Winzeler, Edward Wojcik, Melanie Wree, Wesley Wu, Naoaki Yokoyama, Paul H A Zollo, Nada Abla, Benjamin Blasco, Jeremy Burrows, Benoît Laleu, Didier Leroy, Thomas Spangenberg, Timothy Wells, Paul A Willis
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is still largely within industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of physical compounds, which would accelerate the finding of new starting points for drug discovery...
July 2016: PLoS Pathogens
Eugenio Mercuri, Richard Finkel, Jacqueline Montes, Elena S Mazzone, Maria Pia Sormani, Marion Main, Danielle Ramsey, Anna Mayhew, Allan M Glanzman, Sally Dunaway, Rachel Salazar, Amy Pasternak, Janet Quigley, Marika Pane, Maria Carmela Pera, Mariacristina Scoto, Sonia Messina, Maria Sframeli, Gian Luca Vita, Adele D'Amico, Marleen van den Hauwe, Serena Sivo, Nathalie Goemans, Petra Kaufmann, Basil T Darras, Enrico Bertini, Francesco Muntoni, Darryl C De Vivo
The aim of the study was to establish 12-month changes in the Hammersmith Functional motor scale in a large cohort of SMA patients, to identify patterns of disease progression and the effect of different variables. 268 patients were included in this multicentric study. Their age ranged between 2.5 and 55.5 years at baseline, 68 were ambulant and 200 non-ambulant. The baseline scores ranged between 0 and 66 (mean 23.91, SD 20.09). The 12-month change was between -14 and +9 (mean -0.56, SD 2.72). Of the 268 patients, 206 (76...
February 2016: Neuromuscular Disorders: NMD
Nirmal Adhikari, Ashish Dubey, Eman A Gaml, Bjorn Vaagensmith, Khan Mamun Reza, Sally Adel Abdelsalam Mabrouk, Shaopeng Gu, Jiantao Zai, Xuefeng Qian, Qiquan Qiao
An optimal small amount of water added into methyl ammonium iodide (MAI) solution in isopropyl alcohol (IPA) helps perovskite crystallization and leads to larger grain size from sequential deposition of perovskite films. The concentration of water was varied from 1% to 7% (vol% of IPA) in MAI solution and optical absorption, crystallization, morphology of perovskite films and their photovoltaic performance were studied in perovskite solar cells. 5% by volume was found to lead to preferential crystallization in the (110) plane with grain size about three times that of perovskite films prepared without adding water into the MAI solution...
February 7, 2016: Nanoscale
Farida El Baz Mohamed, Eman Ahmed Zaky, Adel Bassuoni El-Sayed, Reham Mohammed Elhossieny, Sally Soliman Zahra, Waleed Salah Eldin, Walaa Yousef Youssef, Rania Abdelmgeed Khaled, Azza Mohamed Youssef
BACKGROUND AND AIMS: The etiological factors involved in the etiology of autism remain elusive and controversial, but both genetic and environmental factors have been implicated. The aim of this study was to assess the levels and possible environmental risk factors and sources of exposure to mercury, lead, and aluminum in children with autism spectrum disorder (ASD) as compared to their matched controls. METHODS: One hundred ASD children were studied in comparison to 100 controls...
2015: Behavioural Neurology
Filip Zmuda, Gaurav Malviya, Adele Blair, Marie Boyd, Anthony J Chalmers, Andrew Sutherland, Sally L Pimlott
Interest in nuclear imaging of poly(ADP-ribose) polymerase-1 (PARP-1) has grown in recent years due to the ability of PARP-1 to act as a biomarker for glioblastoma and increased clinical use of PARP-1 inhibitors. This study reports the identification of a lead iodinated analog 5 of the clinical PARP-1 inhibitor olaparib as a potential single-photon emission computed tomography (SPECT) imaging agent. Compound 5 was shown to be a potent PARP-1 inhibitor in cell-free and cellular assays, and it exhibited mouse plasma stability but approximately 3-fold greater intrinsic clearance when compared to olaparib...
November 12, 2015: Journal of Medicinal Chemistry
Elena Mazzone, Jacqueline Montes, Marion Main, Anna Mayhew, Danielle Ramsey, Allan M Glanzman, Sally Dunaway, Rachel Salazar, Amy Pasternak, Janet Quigley, Marika Pane, Maria C Pera, Mariacristina Scoto, Sonia Messina, Maria Sframeli, Adele D'amico, Marleen Van Den Hauwe, Serena Sivo, Nathalie Goemans, Basil T Darras, Petra Kaufmann, Enrico Bertini, Darryl C De Vivo, Francesco Muntoni, Richard Finkel, Eugenio Mercuri
INTRODUCTION: A recent Rasch analysis performed on the Hammersmith Functional Motor Scale-Expanded (HFMSE) in patients with spinal muscular atrophy (SMA) identified issues impacting scale validity, redundant items, and disordered thresholds on some items. METHODS: We modified the HMFSE scoring based on the Rasch analysis and on expert consensus to establish whether the traditional scoring overestimated the number of patients with changes within 2 points from baseline...
September 2015: Muscle & Nerve
Sally Adel, Nermeen Adel ElKasabgy
CONTEXT: Drotaverine hydrochloride (DRT) is used to treat gastrointestinal spasms accompanied with diarrhoea. Hence, the drug suffers from brief residence in the highly moving intestine during diarrhoea which leads to poor bioavailability and frequent dosing. OBJECTIVE: This study aimed to extend DRT residence in the stomach. METHODS: Calcium alginate floating beads were prepared using sodium alginate, isopropylmyristate (oil), and Gelucire® 43/01 (lipid) adopting emulsion gelation technique...
June 2014: Journal of Liposome Research
Ossama Rasslan, Zeinab Salah Seliem, Islam Abdullorziz Ghazi, Muhamed Abd El Sabour, Amani Ali El Kholy, Fatma Mohamed Sadeq, Mahmoud Kalil, Doaa Abdel-Aziz, Hosnia Yousif Sharaf, Adel Saeed, Hala Agha, Sally Abd El-Wadood Zein El-Abdeen, Maha El Gafarey, Amira El Tantawy, Lamia Fouad, Mona M Abel-Haleim, Tamer Muhamed, Hedya Saeed, Victor D Rosenthal
PURPOSE: To determine the rate of device-associated healthcare-associated infections (DA-HAIs) at a respiratory intensive care unit (RICU) and in the pediatric intensive care units (PICUs) of member hospitals of the International Nosocomial Infection Control Consortium (INICC) in Egypt. MATERIALS AND METHODS: A prospective cohort DA-HAI surveillance study was conducted from December 2008 to July 2010 by applying the methodology of the INICC and the definitions of the NHSN-CDC...
December 2012: Journal of Infection and Public Health
Kachina Allen, Francisco Pereira, Matthew Botvinick, Adele E Goldberg
All linguistic and psycholinguistic theories aim to provide psychologically valid analyses of particular grammatical patterns and the relationships that hold among them. Until recently, no tools were available to distinguish neural correlates of particular grammatical constructions that shared the same content words, propositional meaning, and degree of surface complexity, such as the dative (e.g., Sally gave the book to Joe) and the ditransitive (e.g., Sally gave Joe a book). We report the first fMRI data that distinguish such closely related, abstract grammatical patterns...
December 2012: Brain and Language
Sally S El-Nakkady, Hanaa F Roaiah, Weam S El-Serwy, Abdel Mohsen Soliman, Sherein I Abd El-Moez, Adel A H Abdel-Rahman
Bromination of visnaginone (1) yielded the dibromo derivative (2), which upon methylation with methyl iodide gave 1-(2,7-dibromo-4,6-dimethoxybenzofuran-5-yl) ethanone (3). Compound (3) reacted with dimethylformamide dimethylacetal to give (4). The reaction of (3) with aromatic aldehydes namely (vanillin, benzaldehyde and 3-anisaldehyde) in ammonium acetate, malononitrile and/or butyric cyanoanhydride gave the 2-amino substituted nicotinonitriles (5a-c) and the 2-hydroxyl substituted nicotinonitriles (7a-c), respectively, while in piperidine gave (E)-1-(2,7-dibromo-4,6-dimethoxybenzofuran-5-yl)-3-(substituted)prop-2-en-l-one (11a-c)...
July 2012: Acta Poloniae Pharmaceutica
Francesca M Bosco, Adele Bono, Bruno G Bara
UNLABELLED: The aim of the present research is to perform a detailed and empirical investigation of schizophrenia patients' deficits in recognizing and recovering a communicative failure. In particular, this paper investigates the role of Theory of Mind (ToM) and of the complexity of the mental representations involved in explaining patients' deficits in recognizing and recovering different kinds of communicative failures, i.e. failure of the expressive act, failure of communicative meaning and failure of the communicative effect...
May 2012: Journal of Communication Disorders
Phillippa C Oakford, Sally R James, Abeer Qadi, Alison C West, Shannon N Ray, Andrew G Bert, Peter N Cockerill, Adele F Holloway
The RUNX1 gene, which is essential for normal hematopoiesis, is frequently rearranged by the t(8;21) chromosomal translocation in acute myeloid leukemia. The resulting RUNX1-ETO fusion protein contributes to leukemic progression by directing aberrant association of transcriptional cofactors and epigenetic modifiers to RUNX1 target genes. For example, the GM-CSF gene is activated by RUNX1, but is repressed by RUNX1-ETO. Here we show that RUNX1 normally cooperates with the histone acetyltransferase, CBP, to regulate GM-CSF expression at two levels...
September 2010: Leukemia Research
Leonard W Seymour, David R Ferry, David J Kerr, Daniel Rea, Maggie Whitlock, Richard Poyner, Christopher Boivin, Stuart Hesslewood, Christopher Twelves, Robert Blackie, Andreas Schatzlein, Duncan Jodrell, Donald Bissett, Hilary Calvert, Mike Lind, Adele Robbins, Sally Burtles, Ruth Duncan, James Cassidy
Phase I studies of [N-(2-hydroxypropyl)methacrylamide] (HPMA) copolymer-doxorubicin previously showed signs of activity coupled with 5-fold decreased anthracycline toxicity in chemotherapy-refractory patients. Here we report phase II studies using a similar material (FCE28068) in patients with breast (n=17), non-small cell lung (NSCLC, n=29) and colorectal (n=16) cancer. Up to 8 courses of PK1 (280 mg/m(2) doxorubicin-equivalent) were given i.v., together with 123I-labelled imaging analogue. Toxicities were tolerable, with grade 3 neutropenia more prominent in patients with breast cancer (4/17, 23...
June 2009: International Journal of Oncology
Christopher S Peacock, Kathy Seeger, David Harris, Lee Murphy, Jeronimo C Ruiz, Michael A Quail, Nick Peters, Ellen Adlem, Adrian Tivey, Martin Aslett, Arnaud Kerhornou, Alasdair Ivens, Audrey Fraser, Marie-Adele Rajandream, Tim Carver, Halina Norbertczak, Tracey Chillingworth, Zahra Hance, Kay Jagels, Sharon Moule, Doug Ormond, Simon Rutter, Rob Squares, Sally Whitehead, Ester Rabbinowitsch, Claire Arrowsmith, Brian White, Scott Thurston, Frédéric Bringaud, Sandra L Baldauf, Adam Faulconbridge, Daniel Jeffares, Daniel P Depledge, Samuel O Oyola, James D Hilley, Loislene O Brito, Luiz R O Tosi, Barclay Barrell, Angela K Cruz, Jeremy C Mottram, Deborah F Smith, Matthew Berriman
Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons...
July 2007: Nature Genetics
Adele H Marshall, Barry Shaw, Sally I McClean
The length of stay in hospital of geriatric patients may be modelled using the Coxian phase-type distribution. This paper examines previous methods which have been used to model health-care costs and presents a new methodology to estimate the costs for a cohort of patients for their duration of stay in hospital, assuming there are no further admissions. The model, applied to 1392 patients admitted into the geriatric ward of a local hospital in Northern Ireland, between 2002 and 2003, should be beneficial to hospital managers, as future decisions and policy changes could be tested on the model to investigate their influence on costs before the decisions were carried out on a real ward...
June 15, 2007: Statistics in Medicine
Asis Khan, Ulrike Böhme, Krystyna A Kelly, Ellen Adlem, Karen Brooks, Mark Simmonds, Karen Mungall, Michael A Quail, Claire Arrowsmith, Tracey Chillingworth, Carol Churcher, David Harris, Matthew Collins, Nigel Fosker, Audrey Fraser, Zahra Hance, Kay Jagels, Sharon Moule, Lee Murphy, Susan O'Neil, Marie-Adele Rajandream, David Saunders, Kathy Seeger, Sally Whitehead, Thomas Mayr, Xuenan Xuan, Junichi Watanabe, Yutaka Suzuki, Hiroyuki Wakaguri, Sumio Sugano, Chihiro Sugimoto, Ian Paulsen, Aaron J Mackey, David S Roos, Neil Hall, Matthew Berriman, Bart Barrell, L David Sibley, James W Ajioka
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of a sexual phase in the life cycle, T. gondii has an unusual population structure dominated by three clonal lineages that predominate in North America and Europe, (Types I, II, and III). These lineages were founded by common ancestors approximately10,000 yr ago. The recent origin and widespread distribution of the clonal lineages is attributed to the circumvention of the sexual cycle by a new mode of transmission-asexual transmission between intermediate hosts...
September 2006: Genome Research
Alvin B Ko, Adel Assaad, Sally E Carty, E Leon Barnes, Barry M Schaitkin
Branchial cleftlike cysts of the thyroid gland are rare lesions. Although initially described in patients with chronic lymphocytic thyroiditis, these cysts have been reported in a variety of histologic settings. We present 2 case studies, 1 in a 30-year-old woman and 1 in a 50-year-old man. The mode of presentation and management of these cases, along with a literature review, is discussed in brief.
March 2006: American Journal of Otolaryngology
Matthew Berriman, Elodie Ghedin, Christiane Hertz-Fowler, Gaëlle Blandin, Hubert Renauld, Daniella C Bartholomeu, Nicola J Lennard, Elisabet Caler, Nancy E Hamlin, Brian Haas, Ulrike Böhme, Linda Hannick, Martin A Aslett, Joshua Shallom, Lucio Marcello, Lihua Hou, Bill Wickstead, U Cecilia M Alsmark, Claire Arrowsmith, Rebecca J Atkin, Andrew J Barron, Frederic Bringaud, Karen Brooks, Mark Carrington, Inna Cherevach, Tracey-Jane Chillingworth, Carol Churcher, Louise N Clark, Craig H Corton, Ann Cronin, Rob M Davies, Jonathon Doggett, Appolinaire Djikeng, Tamara Feldblyum, Mark C Field, Audrey Fraser, Ian Goodhead, Zahra Hance, David Harper, Barbara R Harris, Heidi Hauser, Jessica Hostetler, Al Ivens, Kay Jagels, David Johnson, Justin Johnson, Kristine Jones, Arnaud X Kerhornou, Hean Koo, Natasha Larke, Scott Landfear, Christopher Larkin, Vanessa Leech, Alexandra Line, Angela Lord, Annette Macleod, Paul J Mooney, Sharon Moule, David M A Martin, Gareth W Morgan, Karen Mungall, Halina Norbertczak, Doug Ormond, Grace Pai, Chris S Peacock, Jeremy Peterson, Michael A Quail, Ester Rabbinowitsch, Marie-Adele Rajandream, Chris Reitter, Steven L Salzberg, Mandy Sanders, Seth Schobel, Sarah Sharp, Mark Simmonds, Anjana J Simpson, Luke Tallon, C Michael R Turner, Andrew Tait, Adrian R Tivey, Susan Van Aken, Danielle Walker, David Wanless, Shiliang Wang, Brian White, Owen White, Sally Whitehead, John Woodward, Jennifer Wortman, Mark D Adams, T Martin Embley, Keith Gull, Elisabetta Ullu, J David Barry, Alan H Fairlamb, Fred Opperdoes, Barclay G Barrell, John E Donelson, Neil Hall, Claire M Fraser, Sara E Melville, Najib M El-Sayed
African trypanosomes cause human sleeping sickness and livestock trypanosomiasis in sub-Saharan Africa. We present the sequence and analysis of the 11 megabase-sized chromosomes of Trypanosoma brucei. The 26-megabase genome contains 9068 predicted genes, including approximately 900 pseudogenes and approximately 1700 T. brucei-specific genes. Large subtelomeric arrays contain an archive of 806 variant surface glycoprotein (VSG) genes used by the parasite to evade the mammalian immune system. Most VSG genes are pseudogenes, which may be used to generate expressed mosaic genes by ectopic recombination...
July 15, 2005: Science
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