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Bernard carroll

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https://www.readbyqxmd.com/read/29275977/diagnosis-of-multiple-sclerosis-2017-revisions-of-the-mcdonald-criteria
#1
REVIEW
Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, Timothy Coetzee, Giancarlo Comi, Jorge Correale, Franz Fazekas, Massimo Filippi, Mark S Freedman, Kazuo Fujihara, Steven L Galetta, Hans Peter Hartung, Ludwig Kappos, Fred D Lublin, Ruth Ann Marrie, Aaron E Miller, David H Miller, Xavier Montalban, Ellen M Mowry, Per Soelberg Sorensen, Mar Tintoré, Anthony L Traboulsee, Maria Trojano, Bernard M J Uitdehaag, Sandra Vukusic, Emmanuelle Waubant, Brian G Weinshenker, Stephen C Reingold, Jeffrey A Cohen
The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation...
December 21, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29230032/carmen-keith-conners
#2
Bernard J Carroll
No abstract text is available yet for this article.
January 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29209378/extrapyramidal-signs-and-risk-of-progression-from-mild-cognitive-impairment-to-dementia-a-clinical-research-center-for-dementia-of-south-korea-study
#3
Woojae Myung, Jin Hong Park, Sook-Young Woo, Seonwoo Kim, Sang Ha Kim, Jae Won Chung, Hyo Shin Kang, Shinn-Won Lim, Junbae Choi, Duk L Na, Seong Yoon Kim, Jae-Hong Lee, Seol-Heui Han, Seong Hye Choi, Sang Yun Kim, Bernard J Carroll, Doh Kwan Kim
Objective: Extrapyramidal signs (EPS) are common in patients with mild cognitive impairment (MCI). However, few studies have assessed the effect of EPS on the clinical course of MCI. We aimed to evaluate whether patients with EPS show more frequent progression from MCI to Alzheimer's disease (AD) and to other types of dementia. Methods: Participants (n=882) with MCI were recruited, and were followed for up to 5 years. The EPS positive group was defined by the presence of at least one EPS based on a focused neurologic examination at baseline...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28930496/american-telemedicine-association-practice-guidelines-for-telemental-health-with-children-and-adolescents
#4
Kathleen Myers, Eve-Lynn Nelson, Terry Rabinowitz, Donald Hilty, Deborah Baker, Sara Smucker Barnwell, Geoffrey Boyce, Lynn F Bufka, Sharon Cain, Lisa Chui, Jonathan S Comer, Carroll Cradock, Felissa Goldstein, Barb Johnston, Elizabeth Krupinski, Katherine Lo, David D Luxton, S David McSwain, Jennifer McWilliams, Steve North, Jay Ostrowsky, Antonio Pignatiello, David Roth, Jay Shore, Carolyn Turvey, James R Varrell, Shawna Wright, Jordana Bernard
No abstract text is available yet for this article.
October 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28928141/a-genetic-screen-for-impaired-systemic-rnai-highlights-the-crucial-role-of-dicer-like-2
#5
Christelle Taochy, Nial R Gursanscky, Jiangling Cao, Stephen J Fletcher, Uwe Dressel, Neena Mitter, Matthew R Tucker, Anna M G Koltunow, John L Bowman, Hervé Vaucheret, Bernard J Carroll
Posttranscriptional gene silencing (PTGS) of transgenes involves abundant 21-nucleotide small interfering RNAs (siRNAs) and low-abundance 22-nucleotide siRNAs produced from double-stranded RNA (dsRNA) by DCL4 and DCL2, respectively. However, DCL2 facilitates the recruitment of RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) to ARGONAUTE 1-derived cleavage products, resulting in more efficient amplification of secondary and transitive dsRNA and siRNAs. Here, we describe a reporter system where RDR6-dependent PTGS is initiated by restricted expression of an inverted-repeat dsRNA specifically in the Arabidopsis (Arabidopsis thaliana) root tip, allowing a genetic screen to identify mutants impaired in RDR6-dependent systemic PTGS...
November 2017: Plant Physiology
https://www.readbyqxmd.com/read/28778033/induction-of-virus-resistance-by-exogenous-application-of-double-stranded-rna
#6
REVIEW
Neena Mitter, Elizabeth A Worrall, Karl E Robinson, Zhi Ping Xu, Bernard J Carroll
Exogenous application of double-stranded RNA (dsRNA) for virus resistance in plants represents a very attractive alternative to virus resistant transgenic crops or pesticides targeting virus vectors. However, the instability of dsRNA sprayed onto plants is a major challenge as spraying naked dsRNA onto plants provides protection against homologous viruses for only 5 days. Innovative approaches, such as the use of nanoparticles as carriers of dsRNA for improved stability and sustained release, are emerging as key disruptive technologies...
October 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28714547/beyond-symptom-counts-to-case-wise-probabilities
#7
Bernard J Carroll
No abstract text is available yet for this article.
August 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28684388/keith-conners
#8
Allen Frances, Bernard J Carroll
No abstract text is available yet for this article.
July 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28590369/adverse-events-with-sustained-release-donepezil-in-alzheimer-disease-relation-to-body-mass-index
#9
Chunsoo Lee, Kyungsang Lee, Hyewon Yu, Seung-Ho Ryu, Seok Woo Moon, Changsu Han, Jun-Young Lee, Young Min Lee, Shin-Gyeom Kim, Ki Woong Kim, Dong Woo Lee, Seong Yoon Kim, Sang-Yeol Lee, Jae Nam Bae, Young-Eun Jung, Jeong Lan Kim, Byung-Soo Kim, Il-Seon Shin, Young Hoon Kim, Bong Jo Kim, Hyo Shin Kang, Woojae Myung, Bernard J Carroll, Doh Kwan Kim
PURPOSE/BACKGROUND: Sustained-release, high-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trial, body weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. METHODS/PROCEDURES: To clarify whether this finding is consistent across ethnic groups that vary in absolute body mass, we recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10 mg/d for at least 3 months...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28214789/-truth-in-research-labelling-regarding-wame-s-quoted-comments
#10
COMMENT
Margaret Winker
No abstract text is available yet for this article.
July 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28067898/clay-nanosheets-for-topical-delivery-of-rnai-for-sustained-protection-against-plant-viruses
#11
Neena Mitter, Elizabeth A Worrall, Karl E Robinson, Peng Li, Ritesh G Jain, Christelle Taochy, Stephen J Fletcher, Bernard J Carroll, G Q Max Lu, Zhi Ping Xu
Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attractive alternative to transgenic RNA interference (RNAi). However, the instability of naked dsRNA sprayed on plants has been a major challenge towards its practical application. We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxide (LDH) clay nanosheets. Once loaded on LDH, the dsRNA does not wash off, shows sustained release and can be detected on sprayed leaves even 30 days after application...
January 9, 2017: Nature Plants
https://www.readbyqxmd.com/read/27716180/generation-of-an-integrated-hieracium-genomic-and-transcriptomic-resource-enables-exploration-of-small-rna-pathways-during-apomixis-initiation
#12
David S Rabiger, Jennifer M Taylor, Andrew Spriggs, Melanie L Hand, Steven T Henderson, Susan D Johnson, Karsten Oelkers, Maria Hrmova, Keisuke Saito, Go Suzuki, Yasuhiko Mukai, Bernard J Carroll, Anna M G Koltunow
BACKGROUND: Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tissue transcriptomes in most apomicts. RESULTS: A genomic and transcriptomic resource was developed for Hieracium subgenus Pilosella (Asteraceae) which incorporates characterized sexual, apomictic and mutant apomict plants exhibiting reversion to sexual reproduction...
October 6, 2016: BMC Biology
https://www.readbyqxmd.com/read/27662289/occupational-attainment-as-risk-factor-for%C3%A2-progression-from-mild-cognitive-impairment-to-alzheimer-s-disease-a%C3%A2-credos-study
#13
Woojae Myung, Chunsoo Lee, Jin Hong Park, Sook-Young Woo, Seonwoo Kim, Sangha Kim, Jae Won Chung, Hyo Shin Kang, Shinn-Won Lim, Junbae Choi, Duk L Na, Seong Yoon Kim, Jae-Hong Lee, Seol-Heui Han, Seong Hye Choi, Sang Yun Kim, Bernard J Carroll, Doh Kwan Kim
High occupational attainment has been known as a marker of cognitive reserve. Previous studies in the general population have shown that high occupational attainment is associated with reduced risk of Alzheimer's disease (AD). However, few studies have assessed the effect of occupational attainment on the clinical course of mild cognitive impairment (MCI). In this study, we evaluated whether individuals with high occupational attainment show more frequent progression from MCI to AD. Participants (n = 961) with MCI were recruited from a nationwide, hospital-based multi-center cohort, and were followed for up to 60 months (median: 17...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27601084/a-new-autosomal-dominant-eye-and-lung-syndrome-linked-to-mutations-in-timp3-gene
#14
Isabelle Meunier, Béatrice Bocquet, Gilles Labesse, Christina Zeitz, Sabine Defoort-Dhellemmes, Annie Lacroux, Martine Mauget-Faysse, Isabelle Drumare, Anne-Sophie Gamez, Cyril Mathieu, Virginie Marquette, Lola Sagot, Claire-Marie Dhaenens, Carl Arndt, Patrick Carroll, Martine Remy-Jardin, Salomon Yves Cohen, José-Alain Sahel, Bernard Puech, Isabelle Audo, Sarah Mrejen, Christian P Hamel
To revisit the autosomal dominant Sorsby fundus dystrophy (SFD) as a syndromic condition including late-onset pulmonary disease. We report clinical and imaging data of ten affected individuals from 2 unrelated families with SFD and carrying heterozygous TIMP3 mutations (c.572A > G, p.Y191C, exon 5, in family 1 and c.113C > G, p.S38C, exon 1, in family 2). In family 1, all SFD patients older than 50 (two generations) had also a severe emphysema, despite no history of smoking or asthma. In the preceding generation, the mother died of pulmonary emphysema and she was blind after the age of 50...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27348213/metagenomics-unveils-the-attributes-of-the-alginolytic-guilds-of-sediments-from-four-distant-cold-coastal-environments
#15
Marina N Matos, Mariana Lozada, Luciano E Anselmino, Matías A Musumeci, Bernard Henrissat, Janet K Jansson, Walter P Mac Cormack, JoLynn Carroll, Sara Sjöling, Leif Lundgren, Hebe M Dionisi
Alginates are abundant polysaccharides in brown algae that constitute an important energy source for marine heterotrophic bacteria. Despite the key role of alginate degradation processes in the marine carbon cycle, little information is available on the bacterial populations involved in these processes. The aim of this work was to gain a better understanding of alginate utilization capabilities in cold coastal environments. Sediment metagenomes from four high-latitude regions of both Hemispheres were interrogated for alginate lyase gene homologue sequences and their genomic context...
December 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27193359/epitrochlear-cat-scratch-disease-unique-imaging-features-allowing-differentiation-from-other-soft-tissue-masses-of-the-medial-arm
#16
Stephanie A Bernard, Eric A Walker, John F Carroll, Mary Klassen-Fischer, Mark D Murphey
OBJECTIVE: Evaluate anatomic and imaging features of epitrochlear regional adenopathy secondary to cat scratch disease (CSD) to assist differentiation of CSD from other soft tissue masses at the elbow. MATERIALS AND METHODS: Retrospective review of 24 confirmed cases of CSD. Patient demographics, clinical presentation and radiographic (R; n = 10), CT (n = 3), ultrasound (US; n = 5), and MR (n = 21) images were reviewed. Lesion location, size, number of masses, and intrinsic characteristics on R/CT/US/MR and presence of soft tissue inflammatory changes or adjacent bone or joint involvement were established through the consensus interpretation by four musculoskeletal radiologists...
September 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27013954/statistical-enrichment-of-epigenetic-states-around-triplet-repeats-that-can-undergo-expansions
#17
Alexandra Essebier, Patricia Vera Wolf, Minh Duc Cao, Bernard J Carroll, Sureshkumar Balasubramanian, Mikael Bodén
More than 30 human genetic diseases are linked to tri-nucleotide repeat expansions. There is no known mechanism that explains repeat expansions in full, but changes in the epigenetic state of the associated locus has been implicated in the disease pathology for a growing number of examples. A comprehensive comparative analysis of the genomic features associated with diverse repeat expansions has been lacking. Here, in an effort to decipher the propensity of repeats to undergo expansion and result in a disease state, we determine the genomic coordinates of tri-nucleotide repeat tracts at base pair resolution and computationally establish epigenetic profiles around them...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26885859/a-common-variant-in-the-adaptor-mal-regulates-interferon-gamma-signaling
#18
Clíona Ní Cheallaigh, Frederick J Sheedy, James Harris, Natalia Muñoz-Wolf, Jinhee Lee, Kim West, Eva Palsson McDermott, Alicia Smyth, Laura E Gleeson, Michelle Coleman, Nuria Martinez, Claire H A Hearnden, Graham A Tynan, Elizabeth C Carroll, Sarah A Jones, Sinéad C Corr, Nicholas J Bernard, Mark M Hughes, Sarah E Corcoran, Mary O'Sullivan, Ciara M Fallon, Hardy Kornfeld, Douglas Golenbock, Stephen V Gordon, Luke A J O'Neill, Ed C Lavelle, Joseph Keane
Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. The reason for this difference in susceptibility is not clear. We report that Mal has a TLR-independent role in interferon-gamma (IFN-γ) receptor signaling. Mal-dependent IFN-γ receptor (IFNGR) signaling led to mitogen-activated protein kinase (MAPK) p38 phosphorylation and autophagy...
February 16, 2016: Immunity
https://www.readbyqxmd.com/read/26840485/real-time-portable-genome-sequencing-for-ebola-surveillance
#19
Joshua Quick, Nicholas J Loman, Sophie Duraffour, Jared T Simpson, Ettore Severi, Lauren Cowley, Joseph Akoi Bore, Raymond Koundouno, Gytis Dudas, Amy Mikhail, Nobila Ouédraogo, Babak Afrough, Amadou Bah, Jonathan Hj Baum, Beate Becker-Ziaja, Jan-Peter Boettcher, Mar Cabeza-Cabrerizo, Alvaro Camino-Sanchez, Lisa L Carter, Juiliane Doerrbecker, Theresa Enkirch, Isabel Graciela García Dorival, Nicole Hetzelt, Julia Hinzmann, Tobias Holm, Liana Eleni Kafetzopoulou, Michel Koropogui, Abigail Kosgey, Eeva Kuisma, Christopher H Logue, Antonio Mazzarelli, Sarah Meisel, Marc Mertens, Janine Michel, Didier Ngabo, Katja Nitzsche, Elisa Pallash, Livia Victoria Patrono, Jasmine Portmann, Johanna Gabriella Repits, Natasha Yasmin Rickett, Andrea Sachse, Katrin Singethan, Inês Vitoriano, Rahel L Yemanaberhan, Elsa G Zekeng, Racine Trina, Alexander Bello, Amadou Alpha Sall, Ousmane Faye, Oumar Faye, N'Faly Magassouba, Cecelia V Williams, Victoria Amburgey, Linda Winona, Emily Davis, Jon Gerlach, Franck Washington, Vanessa Monteil, Marine Jourdain, Marion Bererd, Alimou Camara, Hermann Somlare, Abdoulaye Camara, Marianne Gerard, Guillaume Bado, Bernard Baillet, Déborah Delaune, Koumpingnin Yacouba Nebie, Abdoulaye Diarra, Yacouba Savane, Raymond Bernard Pallawo, Giovanna Jaramillo Gutierrez, Natacha Milhano, Isabelle Roger, Christopher J Williams, Facinet Yattara, Kuiama Lewandowski, Jamie Taylor, Philip Rachwal, Daniel Turner, Georgios Pollakis, Julian A Hiscox, David A Matthews, Matthew K O'Shea, Andrew McD Johnston, Duncan Wilson, Emma Hutley, Erasmus Smit, Antonino Di Caro, Roman Woelfel, Kilian Stoecker, Erna Fleischmann, Martin Gabriel, Simon A Weller, Lamine Koivogui, Boubacar Diallo, Sakoba Keita, Andrew Rambaut, Pierre Formenty, Stephan Gunther, Miles W Carroll
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is desirable to characterize the infectious agent and determine its evolutionary rate. Genome sequencing also allows the identification of signatures of host adaptation, identification and monitoring of diagnostic targets, and characterization of responses to vaccines and treatments. The Ebola virus (EBOV) genome substitution rate in the Makona strain has been estimated at between 0...
February 11, 2016: Nature
https://www.readbyqxmd.com/read/26808923/cytorhabdovirus-p-protein-suppresses-risc-mediated-cleavage-and-rna-silencing-amplification-in-planta
#20
Krin S Mann, Karyn N Johnson, Bernard J Carroll, Ralf G Dietzgen
Plant viruses have evolved to undermine the RNA silencing pathway by expressing suppressor protein(s) that interfere with one or more key components of this antiviral defense. Here we show that the recently identified RNA silencing suppressor (RSS) of lettuce necrotic yellows virus (LNYV), phosphoprotein P, binds to RNA silencing machinery proteins AGO1, AGO2, AGO4, RDR6 and SGS3 in protein-protein interaction assays when transiently expressed. In planta, we demonstrate that LNYV P inhibits miRNA-guided AGO1 cleavage and translational repression, and RDR6/SGS3-dependent amplification of silencing...
March 2016: Virology
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