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Bernard carroll

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https://www.readbyqxmd.com/read/29614852/advanced-daily-prediction-model-for-national-suicide-numbers-with-social-media-data
#1
Kyung Sang Lee, Hyewon Lee, Woojae Myung, Gil-Young Song, Kihwang Lee, Ho Kim, Bernard J Carroll, Doh Kwan Kim
Objective: Suicide is a significant public health concern worldwide. Social media data have a potential role in identifying high suicide risk individuals and also in predicting suicide rate at the population level. In this study, we report an advanced daily suicide prediction model using social media data combined with economic/meteorological variables along with observed suicide data lagged by 1 week. Methods: The social media data were drawn from weblog posts...
April 5, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29614656/exposure-to-general-anesthesia-and-risk-of-dementia-a-nationwide-population-based-cohort-study
#2
Clara Tammy Kim, Woojae Myung, Matthew Lewis, Hyewon Lee, Satbyul Estella Kim, Kyungsang Lee, Chunsoo Lee, Junbae Choi, Ho Kim, Bernard J Carroll, Doh Kwan Kim
BACKGROUND: There is a growing concern that general anesthesia could increase the risk of dementia. However, the relationship between anesthesia and subsequent dementia is still undetermined. OBJECTIVE: To determine whether the risk of dementia increases after exposure to general anesthesia. METHODS: A population-based prospective cohort study analyzing the Korean National Health Insurance Service-National Sample Cohort database was conducted of all persons aged over 50 years (n = 219,423) from 1 January 2003 and 31 December 2013...
March 29, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29554210/scram-a-pipeline-for-fast-index-free-small-rna-read-alignment-and-visualization
#3
Stephen J Fletcher, Mikael Boden, Neena Mitter, Bernard J Carroll
Summary: Small RNAs play key roles in gene regulation, defense against viral pathogens and maintenance of genome stability, though many aspects of their biogenesis and function remain to be elucidated. SCRAM (Small Complementary RNA Mapper) is a novel, simple-to-use short read aligner and visualization suite that enhances exploration of small RNA datasets. Availability: The SCRAM pipeline is implemented in Go and Python, and is freely available under MIT license...
March 15, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29486402/clinical-epidemiology-of-long-term-suicide-risk-in-a-nationwide-population-based-cohort-study-in-south-korea
#4
Hyewon Lee, Woojae Myung, Chunsoo Lee, Junbae Choi, Ho Kim, Bernard J Carroll, Doh Kwan Kim
We investigated the effects of a large range of clinical factors on the long-term risk of suicide in the general population of South Korea. We analyzed the National Health Insurance Service-National Sample Cohort (NHIS-NSC) database in South Korea. A total of 300,232 individuals were followed for up to 12 years. We obtained information on demographic variables (age and sex), lifestyle variables (cigarette smoking, alcohol drinking and exercise), psychiatric and physical disorders, laboratory examination results and physical examination findings...
May 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29275977/diagnosis-of-multiple-sclerosis-2017-revisions-of-the-mcdonald-criteria
#5
REVIEW
Alan J Thompson, Brenda L Banwell, Frederik Barkhof, William M Carroll, Timothy Coetzee, Giancarlo Comi, Jorge Correale, Franz Fazekas, Massimo Filippi, Mark S Freedman, Kazuo Fujihara, Steven L Galetta, Hans Peter Hartung, Ludwig Kappos, Fred D Lublin, Ruth Ann Marrie, Aaron E Miller, David H Miller, Xavier Montalban, Ellen M Mowry, Per Soelberg Sorensen, Mar Tintoré, Anthony L Traboulsee, Maria Trojano, Bernard M J Uitdehaag, Sandra Vukusic, Emmanuelle Waubant, Brian G Weinshenker, Stephen C Reingold, Jeffrey A Cohen
The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide the most up-to-date guidance for clinicians and researchers. The International Panel on Diagnosis of Multiple Sclerosis reviewed the 2010 McDonald criteria and recommended revisions. The 2017 McDonald criteria continue to apply primarily to patients experiencing a typical clinically isolated syndrome, define what is needed to fulfil dissemination in time and space of lesions in the CNS, and stress the need for no better explanation for the presentation...
February 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29230032/carmen-keith-conners
#6
Bernard J Carroll
No abstract text is available yet for this article.
January 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29209378/extrapyramidal-signs-and-risk-of-progression-from-mild-cognitive-impairment-to-dementia-a-clinical-research-center-for-dementia-of-south-korea-study
#7
Woojae Myung, Jin Hong Park, Sook-Young Woo, Seonwoo Kim, Sang Ha Kim, Jae Won Chung, Hyo Shin Kang, Shinn-Won Lim, Junbae Choi, Duk L Na, Seong Yoon Kim, Jae-Hong Lee, Seol-Heui Han, Seong Hye Choi, Sang Yun Kim, Bernard J Carroll, Doh Kwan Kim
Objective: Extrapyramidal signs (EPS) are common in patients with mild cognitive impairment (MCI). However, few studies have assessed the effect of EPS on the clinical course of MCI. We aimed to evaluate whether patients with EPS show more frequent progression from MCI to Alzheimer's disease (AD) and to other types of dementia. Methods: Participants (n=882) with MCI were recruited, and were followed for up to 5 years. The EPS positive group was defined by the presence of at least one EPS based on a focused neurologic examination at baseline...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28930496/american-telemedicine-association-practice-guidelines-for-telemental-health-with-children-and-adolescents
#8
Kathleen Myers, Eve-Lynn Nelson, Terry Rabinowitz, Donald Hilty, Deborah Baker, Sara Smucker Barnwell, Geoffrey Boyce, Lynn F Bufka, Sharon Cain, Lisa Chui, Jonathan S Comer, Carroll Cradock, Felissa Goldstein, Barb Johnston, Elizabeth Krupinski, Katherine Lo, David D Luxton, S David McSwain, Jennifer McWilliams, Steve North, Jay Ostrowsky, Antonio Pignatiello, David Roth, Jay Shore, Carolyn Turvey, James R Varrell, Shawna Wright, Jordana Bernard
No abstract text is available yet for this article.
October 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28928141/a-genetic-screen-for-impaired-systemic-rnai-highlights-the-crucial-role-of-dicer-like-2
#9
Christelle Taochy, Nial R Gursanscky, Jiangling Cao, Stephen J Fletcher, Uwe Dressel, Neena Mitter, Matthew R Tucker, Anna M G Koltunow, John L Bowman, Hervé Vaucheret, Bernard J Carroll
Posttranscriptional gene silencing (PTGS) of transgenes involves abundant 21-nucleotide small interfering RNAs (siRNAs) and low-abundance 22-nucleotide siRNAs produced from double-stranded RNA (dsRNA) by DCL4 and DCL2, respectively. However, DCL2 facilitates the recruitment of RNA-DEPENDENT RNA POLYMERASE 6 (RDR6) to ARGONAUTE 1-derived cleavage products, resulting in more efficient amplification of secondary and transitive dsRNA and siRNAs. Here, we describe a reporter system where RDR6-dependent PTGS is initiated by restricted expression of an inverted-repeat dsRNA specifically in the Arabidopsis (Arabidopsis thaliana) root tip, allowing a genetic screen to identify mutants impaired in RDR6-dependent systemic PTGS...
November 2017: Plant Physiology
https://www.readbyqxmd.com/read/28778033/induction-of-virus-resistance-by-exogenous-application-of-double-stranded-rna
#10
REVIEW
Neena Mitter, Elizabeth A Worrall, Karl E Robinson, Zhi Ping Xu, Bernard J Carroll
Exogenous application of double-stranded RNA (dsRNA) for virus resistance in plants represents a very attractive alternative to virus resistant transgenic crops or pesticides targeting virus vectors. However, the instability of dsRNA sprayed onto plants is a major challenge as spraying naked dsRNA onto plants provides protection against homologous viruses for only 5 days. Innovative approaches, such as the use of nanoparticles as carriers of dsRNA for improved stability and sustained release, are emerging as key disruptive technologies...
October 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28714547/beyond-symptom-counts-to-case-wise-probabilities
#11
COMMENT
Bernard J Carroll
No abstract text is available yet for this article.
August 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28684388/keith-conners
#12
Allen Frances, Bernard J Carroll
No abstract text is available yet for this article.
July 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28590369/adverse-events-with-sustained-release-donepezil-in-alzheimer-disease-relation-to-body-mass-index
#13
Chunsoo Lee, Kyungsang Lee, Hyewon Yu, Seung-Ho Ryu, Seok Woo Moon, Changsu Han, Jun-Young Lee, Young Min Lee, Shin-Gyeom Kim, Ki Woong Kim, Dong Woo Lee, Seong Yoon Kim, Sang-Yeol Lee, Jae Nam Bae, Young-Eun Jung, Jeong Lan Kim, Byung-Soo Kim, Il-Seon Shin, Young Hoon Kim, Bong Jo Kim, Hyo Shin Kang, Woojae Myung, Bernard J Carroll, Doh Kwan Kim
PURPOSE/BACKGROUND: Sustained-release, high-dose (23 mg/d) donepezil has been approved for treatment of moderate to severe Alzheimer disease (AD). Based on a previous clinical trial, body weight of less than 55 kg is a risk factor for adverse events with donepezil 23 mg/d treatment in global population. METHODS/PROCEDURES: To clarify whether this finding is consistent across ethnic groups that vary in absolute body mass, we recruited Korean patients aged 45 to 90 years with moderate to severe AD who had been receiving standard donepezil immediate release 10 mg/d for at least 3 months...
August 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28214789/-truth-in-research-labelling-regarding-wame-s-quoted-comments
#14
COMMENT
Margaret Winker
No abstract text is available yet for this article.
July 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28067898/clay-nanosheets-for-topical-delivery-of-rnai-for-sustained-protection-against-plant-viruses
#15
Neena Mitter, Elizabeth A Worrall, Karl E Robinson, Peng Li, Ritesh G Jain, Christelle Taochy, Stephen J Fletcher, Bernard J Carroll, G Q Max Lu, Zhi Ping Xu
Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attractive alternative to transgenic RNA interference (RNAi). However, the instability of naked dsRNA sprayed on plants has been a major challenge towards its practical application. We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxide (LDH) clay nanosheets. Once loaded on LDH, the dsRNA does not wash off, shows sustained release and can be detected on sprayed leaves even 30 days after application...
January 9, 2017: Nature Plants
https://www.readbyqxmd.com/read/27716180/generation-of-an-integrated-hieracium-genomic-and-transcriptomic-resource-enables-exploration-of-small-rna-pathways-during-apomixis-initiation
#16
David S Rabiger, Jennifer M Taylor, Andrew Spriggs, Melanie L Hand, Steven T Henderson, Susan D Johnson, Karsten Oelkers, Maria Hrmova, Keisuke Saito, Go Suzuki, Yasuhiko Mukai, Bernard J Carroll, Anna M G Koltunow
BACKGROUND: Application of apomixis, or asexual seed formation, in crop breeding would allow rapid fixation of complex traits, economizing improved crop delivery. Identification of apomixis genes is confounded by the polyploid nature, high genome complexity and lack of genomic sequence integration with reproductive tissue transcriptomes in most apomicts. RESULTS: A genomic and transcriptomic resource was developed for Hieracium subgenus Pilosella (Asteraceae) which incorporates characterized sexual, apomictic and mutant apomict plants exhibiting reversion to sexual reproduction...
October 6, 2016: BMC Biology
https://www.readbyqxmd.com/read/27662289/occupational-attainment-as-risk-factor-for-progression-from-mild-cognitive-impairment-to-alzheimer-s-disease-a-credos-study
#17
MULTICENTER STUDY
Woojae Myung, Chunsoo Lee, Jin Hong Park, Sook-Young Woo, Seonwoo Kim, Sangha Kim, Jae Won Chung, Hyo Shin Kang, Shinn-Won Lim, Junbae Choi, Duk L Na, Seong Yoon Kim, Jae-Hong Lee, Seol-Heui Han, Seong Hye Choi, Sang Yun Kim, Bernard J Carroll, Doh Kwan Kim
High occupational attainment has been known as a marker of cognitive reserve. Previous studies in the general population have shown that high occupational attainment is associated with reduced risk of Alzheimer's disease (AD). However, few studies have assessed the effect of occupational attainment on the clinical course of mild cognitive impairment (MCI). In this study, we evaluated whether individuals with high occupational attainment show more frequent progression from MCI to AD. Participants (n = 961) with MCI were recruited from a nationwide, hospital-based multi-center cohort, and were followed for up to 60 months (median: 17...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27601084/a-new-autosomal-dominant-eye-and-lung-syndrome-linked-to-mutations-in-timp3-gene
#18
Isabelle Meunier, Béatrice Bocquet, Gilles Labesse, Christina Zeitz, Sabine Defoort-Dhellemmes, Annie Lacroux, Martine Mauget-Faysse, Isabelle Drumare, Anne-Sophie Gamez, Cyril Mathieu, Virginie Marquette, Lola Sagot, Claire-Marie Dhaenens, Carl Arndt, Patrick Carroll, Martine Remy-Jardin, Salomon Yves Cohen, José-Alain Sahel, Bernard Puech, Isabelle Audo, Sarah Mrejen, Christian P Hamel
To revisit the autosomal dominant Sorsby fundus dystrophy (SFD) as a syndromic condition including late-onset pulmonary disease. We report clinical and imaging data of ten affected individuals from 2 unrelated families with SFD and carrying heterozygous TIMP3 mutations (c.572A > G, p.Y191C, exon 5, in family 1 and c.113C > G, p.S38C, exon 1, in family 2). In family 1, all SFD patients older than 50 (two generations) had also a severe emphysema, despite no history of smoking or asthma. In the preceding generation, the mother died of pulmonary emphysema and she was blind after the age of 50...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27348213/metagenomics-unveils-the-attributes-of-the-alginolytic-guilds-of-sediments-from-four-distant-cold-coastal-environments
#19
Marina N Matos, Mariana Lozada, Luciano E Anselmino, Matías A Musumeci, Bernard Henrissat, Janet K Jansson, Walter P Mac Cormack, JoLynn Carroll, Sara Sjöling, Leif Lundgren, Hebe M Dionisi
Alginates are abundant polysaccharides in brown algae that constitute an important energy source for marine heterotrophic bacteria. Despite the key role of alginate degradation processes in the marine carbon cycle, little information is available on the bacterial populations involved in these processes. The aim of this work was to gain a better understanding of alginate utilization capabilities in cold coastal environments. Sediment metagenomes from four high-latitude regions of both Hemispheres were interrogated for alginate lyase gene homologue sequences and their genomic context...
December 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27193359/epitrochlear-cat-scratch-disease-unique-imaging-features-allowing-differentiation-from-other-soft-tissue-masses-of-the-medial-arm
#20
Stephanie A Bernard, Eric A Walker, John F Carroll, Mary Klassen-Fischer, Mark D Murphey
OBJECTIVE: Evaluate anatomic and imaging features of epitrochlear regional adenopathy secondary to cat scratch disease (CSD) to assist differentiation of CSD from other soft tissue masses at the elbow. MATERIALS AND METHODS: Retrospective review of 24 confirmed cases of CSD. Patient demographics, clinical presentation and radiographic (R; n = 10), CT (n = 3), ultrasound (US; n = 5), and MR (n = 21) images were reviewed. Lesion location, size, number of masses, and intrinsic characteristics on R/CT/US/MR and presence of soft tissue inflammatory changes or adjacent bone or joint involvement were established through the consensus interpretation by four musculoskeletal radiologists...
September 2016: Skeletal Radiology
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