Abdurrahman M Fahmy, Doaa Ahmed El-Setouhy, Basant A Habib, Saadia A Tayel
Haloperidol (Hal) is a well-known typical antipsychotic. Hepatic first pass metabolism leads to its limited oral bioavailability. This study aimed at enhancing transdermal delivery of Hal via spanlastic formulae. Hal-loaded spanlastics of Span®60 and an edge activator (EA) were successfully prepared by ethanol injection method according to a 31 .41 full factorial design. In this design, independent variables were X1 , EA type, and X2 , Span®60 to EA ratio. Y1 , percentage entrapment efficiency (EE%); Y2 , particle size (PS); Y3 , deformability index (DI); and Y4 , percentage drug released after 4h (Q4h), were chosen as dependent variables...
January 29, 2019: AAPS PharmSciTech