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JOURNAL ARTICLE
Amr Hassan, Reham Mohsen, Ahmed Rezk, Gabrielle Bangay, Patrícia Rijo, Mona F M Soliman, Mohamed G A Hablas, Khalifa AbdulRazik K Swidan, Tahseen S Mohammed, Mohammad A Zoair, Abir A Khalil Mohamed, Tamer I Abdalrhman, Ahmad M Abdel-Aleem Desoky, Dalia D Mohamed, Doaa D Mohamed, Ahmed I Abd El Maksoud, Aly F Mohamed
Vitamin C was examined to ameliorate the neurotoxicity of thimerosal (THIM) in an animal model (Wistar albino rats). In our work, oxidative and antioxidative biomarkers such as SOD, LPO, and GSH were investigated at various doses of THIM with or without concurrent vitamin C administration. Furthermore, the adverse effects of THIM on hepatic tissue and cerebral cortex morphology were examined in the absence or presence of associated vitamin C administration. Also, we studied the effect of vitamin C on the metallothionein isoforms (MT-1, MT-2, and MT-3) in silico and in vivo using the RT-PCR assay...
February 27, 2024: ACS Omega
#22
JOURNAL ARTICLE
Ayman Alzu'bi, Worood Bani Baker, Bahaa Al-Trad, Mazhar Salim Al Zoubi, Manal Isam AbuAlArjah, Ejlal Abu-El-Rub, Lena Tahat, Ahmed Mnz Helaly, Doaa S Ghorab, Waseem El-Huneidi, Raed M Al-Zoubi
PURPOSE: Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl administration are still unclear. In particular, little is known about its effect on the cerebral cortex. The current study aims to test the chronic toxicity of fentanyl in the mice model. METHODS: Adult male Balb/c mice were chronically treated with low (0...
February 28, 2024: Brain Research Bulletin
#23
JOURNAL ARTICLE
Amany Belal, Atiah H Almalki, Ahmed A Farghali, Rehab Mahmoud, R R Atta, Abeer Enaiet Allah, Walid Hamdy Hassan, Sangmin Lee, Amna A Kotp, Doaa Essam, Ahmed H E Hassan, Mohammed M Ghoneim, Fatma I Abo El-Ela, Abdalla Abdelwahab
Most fungal bone and joint infections (arthritis) are caused by Mucormycosis ( Mucor indicus ). These infections may be difficult to treat and may lead to chronic bone disorders and disabilities, thus the use of new antifungal materials in bone disorders is vital, particularly in immunocompromised individuals, such as those who have contracted coronavirus disease 2019 (COVID-19). Herein, we reported for the first time the preparation of nitrogen-doped carbon quantum dots (N/CQDs) and a nitrogen-doped mesoporous carbon (N/MC) using a quick micro-wave preparation and hydrothermal approach...
December 2024: Artificial Cells, Nanomedicine, and Biotechnology
#24
JOURNAL ARTICLE
Fatma S Hafez, Marwa M Shakweer, Dina Sabry, Amany M Tawfik, Shaimaa Mohsen El-Beah, Nadia M Elsheshtawy, Lobna S Shash, Doaa E A Salama, Ahmed Gaballah
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC) is thought to be related to immune response against gut microbiota. TLR4, IgA, and EpCAM have a role in intestinal local immune response and their altered expression related to both IBD and CRC. Lipopolysaccharide (LPS) is the main activator of TLR4. The objective of this study is to evaluate the possible role of intestinal microbiota in the pathogenesis of IBD and CRC through expression of TLR4, IgA and EpCAM...
February 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
#25
JOURNAL ARTICLE
Konstantinos N Fountoulakis, Jelena Vrublevska, Seri Abraham, Kristina Adorjan, Helal Uddin Ahmed, Renato D Alarcón, Kiyomi Arai, Sani Salihu Auwal, Michael Berk, Sarah Bjedov, Julio Bobes, Teresa Bobes-Bascaran, Julie Bourgin-Duchesnay, Cristina Ana Bredicean, Laurynas Bukelskis, Akaki Burkadze, Indira Indiana Cabrera Abud, Ruby Castilla-Puentes, Marcelo Cetkovich, Hector Colon-Rivera, Ricardo Corral, Carla Cortez-Vergara, Piirika Crepin, Domenico De Berardis, Sergio Zamora Delgado, David De Lucena, Avinash De Sousa, Ramona Di Stefano, Seetal Dodd, Livia Priyanka Elek, Anna Elissa, Berta Erdelyi-Hamza, Gamze Erzin, Martin J Etchevers, Peter Falkai, Adriana Farcas, Ilya Fedotov, Viktoriia Filatova, Nikolaos K Fountoulakis, Iryna Frankova, Francesco Franza, Pedro Frias, Tatiana Galako, Cristian J Garay, Leticia Garcia-Álvarez, Maria Paz García-Portilla, Xenia Gonda, Tomasz M Gondek, Daniela Morera González, Hilary Gould, Paolo Grandinetti, Arturo Grau, Violeta Groudeva, Michal Hagin, Takayuki Harada, Tasdik M Hasan, Nurul Azreen Hashim, Jan Hilbig, Sahadat Hossain, Rossitza Iakimova, Mona Ibrahim, Felicia Iftene, Yulia Ignatenko, Matias Irarrazaval, Zaliha Ismail, Jamila Ismayilova, Asaf Jacobs, Miro Jakovljević, Nenad Jakšić, Afzal Javed, Helin Yilmaz Kafali, Sagar Karia, Olga Kazakova, Doaa Khalifa, Olena Khaustova, Steve Koh, Korneliia Kosenko, Sotirios A Koupidis, Alisha Lalljee, Justine Liewig, Abdul Majid, Evgeniia Malashonkova, Khamelia Malik, Najma Iqbal Malik, Gulay Mammadzada, Bilvesh Mandalia, Donatella Marazziti, Darko Marčinko, Stephanie Martinez, Eimantas Matiekus, Gabriela Mejia, Roha Saeed Memon, Xarah Elenne Meza Martínez, Dalia Mickevičiūtė, Roumen Milev, Muftau Mohammed, Alejandro Molina-López, Petr Morozov, Nuru Suleiman Muhammad, Filip Mustač, Mika S Naor, Amira Nassieb, Alvydas Navickas, Tarek Okasha, Milena Pandova, Anca-Livia Panfil, Liliya Panteleeva, Ion Papava, Mikaella E Patsali, Alexey Pavlichenko, Bojana Pejuskovic, Mariana Pinto Da Costa, Mikhail Popkov, Dina Popovic, Nor Jannah Nasution Raduan, Francisca Vargas Ramírez, Elmars Rancans, Salmi Razali, Federico Rebok, Anna Rewekant, Elena Ninoska Reyes Flores, María Teresa Rivera-Encinas, Pilar Saiz, Manuel Sánchez de Carmona, David Saucedo Martínez, Jo Anne Saw, Görkem Saygili, Patricia Schneidereit, Bhumika Shah, Tomohiro Shirasaka, Ketevan Silagadze, Satti Sitanggang, Oleg Skugarevsky, Anna Spikina, Sridevi Sira Mahalingappa, Maria Stoyanova, Anna Szczegielniak, Simona Claudia Tamasan, Giuseppe Tavormina, Maurilio Giuseppe Maria Tavormina, Pavlos N Theodorakis, Mauricio Tohen, Eva Maria Tsapakis, Dina Tukhvatullina, Irfan Ullah, Ratnaraj Vaidya, Johann M Vega-Dienstmaier, Olivera Vukovic, Olga Vysotska, Natalia Widiasih, Anna Yashikhina, Daria Smirnova
BACKGROUND: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical depression or distress during the pandemic, also in these special populations. METHODS: Chi-square tests were used for initial screening to select only those variables which would show an initial significance. Risk Ratios (RR) were calculated, and a Multiple Backward Stepwise Linear Regression Analysis (MBSLRA) was followed with those variables given significant results at screening and with the presence of distress or depression or the lack of both of them...
February 19, 2024: Journal of Affective Disorders
#26
JOURNAL ARTICLE
Amira S A Attia, Rasha M M Abou Elez, Nashwa El-Gazzar, Shimaa S Elnahriry, Ahmed Alfifi, Helal F Al-Harthi, Dalal Hussien M Alkhalifah, Wael N Hozzein, Hassan Mohmoud Diab, Doaa Ibrahim
INTRODUCTION: Aeromonas hydrophila and methicillin-resistant Staphylococcus aureus (MRSA) are potent bacterial pathogens posing major hazards to human health via consuming fish harboring these pathogens or by cross-contamination beyond the contaminated environment. The aim of this study was to determine risk variables associated with the presence of certain pathogenic bacteria from Mugil cephalus fish in retail markets in Egypt. The virulence genes of A. hydrophila and S. aureus were also studied...
2024: Frontiers in Cellular and Infection Microbiology
#27
JOURNAL ARTICLE
Samar M Mahgoub, Doaa Essam, Zienab E Eldin, S A Abdel Moaty, Mohamed R Shehata, Ahmed Farghali, Saif Elden B Abdalla, Sarah I Othman, Ahmed A Allam, Fatma I Abo El-Ela, Rehab Mahmoud
Fluoxetine (FLX) is one of the most persistent pharmaceuticals found in wastewater due to increased use of antidepressant drugs in recent decades. In this study, a nanocomposite of ternary ZnCoAl layered double hydroxide supported on activated carbon (LAC) was used as an adsorbent for FLX in wastewater effluents. The nanocomposite was characterized using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), and surface area analysis (BET)...
February 17, 2024: Scientific Reports
#28
JOURNAL ARTICLE
Adnan Ahmed Aladraii, Lama Zaki Allehaibi, Amjad Abdulrahman Fattani, Taif Abdullah Alkhudairy, Albatoul Mohammed Al-Margan, Sami Abdo Radman Al-Dubai, Abdulrahman Abdulraof Mohammed, Doaa K Mohorjy, Abdulhakeem Saeed Alqarni
BACKGROUND: Subvastus approach and medial parapatellar approach are two major approaches for total knee replacement (TKR). There is no global consensus on the superiority of either approach in terms of functional outcomes. OBJECTIVE: The present study aimed to evaluate the functional outcome of TKR through subvastus approach and medial parapatellar approach by using patient-reported scores at 3-, 6-, and 12-month post-operative follow-ups. METHODS: This prospective cohort follow-up study included patients with knee osteoarthritis who underwent elective primary TKR either through the subvastus or medial parapatellar approaches at King Abdullah Medical City, Makkah city, Kingdom of Saudi Arabia, from January 2019 to December 2022...
2024: Saudi Journal of Medicine & Medical Sciences
#29
JOURNAL ARTICLE
Reham Hussein Mohamed, Nesma Hussein Abdel Hay, Nesma Mohamed Fawzy, Yomna M Tamim, M M Doaa Karem, Dalia Ahmed Yousef Yehia, Omnia M Abdel Maksoud, Dina S Abdelrahim
BACKGROUND: Rho kinase (ROCK) pathway plays a critical role in post-COVID-19 pulmonary fibrosis (PCPF) and its intervention with angiotensin-converting enzyme 2 (ACE2) and vascular endothelial growth factor (VEGF) will be a potential therapeutic target. OBJECTIVES: The present study was conducted to investigate the efficacy of zoledronate (ZA) on carbon tetrachloride (CCl4) induced pulmonary fibrosis (PF) in rats through targeting ACE2, ROCK, and VEGF signaling pathways...
February 15, 2024: Fundamental & Clinical Pharmacology
#30
JOURNAL ARTICLE
Mohamed Ali Alabiad, Warda M M Said, Rema H Faraj Saad, Rawda Balata, Asmaa A Mahmoud, Elsayed Anany Metwally, Amany Mohamed Shalaby, Walaa Samy, Ahmed M Yehia, Amar Ibrahim Omar Yahia, Mohammed Alorini, Doaa I Abdelrahman
BACKGROUND: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL)...
February 2024: Iranian Journal of Medical Sciences
#31
JOURNAL ARTICLE
Soliman Gamal, Doaa A Kospa, Amr Awad Ibrahim, Awad I Ahmed, A M A Ouf
Ethanol electrooxidation is an important reaction for fuel cells, however, the major obstacle to ethanol electrocatalysis is the splitting of the carbon-carbon bond to CO2 at lower overpotentials. Herein, a ZIF-8@graphene oxide-derived highly porous nitrogen-doped carbonaceous platform containing zinc oxide was attained for supporting a non-precious Ni-based catalyst. The support was doped with the disordered α-phase Ni(OH)2 NPs and Ni NPs that are converted to Ni(OH)2 through potential cycling in alkaline media...
February 7, 2024: RSC Advances
#32
JOURNAL ARTICLE
Nouf M Alyami, Hussah Alobadi, Saleh Maodaa, Norah S Alothman, Hanouf Almukhlafi, Khadijah N Yaseen, Zainab A Alnakhli, Noura M Alshiban, Doaa M Elnagar, Ahmed Rady, Wed A Alharthi, Bader Almetari, Rafa Almeer, Saud Alarifi, Daoud Ali
Nanosized lanthanum oxide particles (La2O3) are commonly utilized in various industries. The potential health risks associated with La2O3 nanoparticles, cytotoxic effects at varying doses and time intervals, and the mechanisms behind their induction of behavioral changes remain uncertain and necessitate further investigation. Therefore, this study examined in vivo hepatotoxicity, considering the quantity (60, 150, and 300 mg/kg) and time-dependent induction of reactive oxygen species (ROS) over one week or 21 days...
February 9, 2024: Environmental Science and Pollution Research International
#33
JOURNAL ARTICLE
Sarah Mamdouh Shoeib, Doaa Elwy Abdeldaim, Shaimaa Samir Mashal, Rowida Raafat Ibrahim, Lamees Mohamed Dawood, Doaa Shatat, Yasmine Ibrahim El-Masry, Ahmed Almeldin, Radwa Mahamoud El Sharaby
BACKGROUND: Preeclampsia (PE) is a multisystem pregnancy disorder that increases maternal-perinatal morbidity and mortality significantly. MicroRNA-155 (miR-155) overexpression in the sera of pregnant women has been linked to preeclampsia. Researchers discovered that miR-155 acts during pregnancy by down-regulating and reducing the cysteine-rich angiogenic inducer 61 (CYR61), which causes local ischemia as well as oxidative stress. METHODS: The level of miR-155 expression in all serum samples was quantified using real-time polymerase chain reaction (RT-PCR), and serum CYR61 was measured using enzyme-linked immunosorbent assays...
July 2023: Reports of Biochemistry & Molecular Biology
#34
JOURNAL ARTICLE
Doaa H S Attia, Ahmed Y Ismaeel, Eman R Mohamed, Nermeen H A Moneim, Yossra A Suliman, Rasha A Abdel Noor
BACKGROUND/OBJECTIVE: Although systemic autoimmune rheumatic diseases (SARDs) seem to be ubiquitous, Africa and the Middle East seem to be a remarkable exception with scarcity of data compared with the developed countries. Furthermore, most of the studies addressed a particular disease. This work aimed to shed light on the relative frequency and epidemiology of the different adult-onset SARDs in Egypt. METHODS: This is a retrospective hospital-based study including six university hospitals providing free health care services: Cairo, Alexandria, Tanta, Ismailia, Beni-Suef and Assiut University Hospitals...
January 16, 2024: Current Rheumatology Reviews
#35
JOURNAL ARTICLE
Konstantinos N Fountoulakis, Gregory Karakatsoulis, Seri Abraham, Kristina Adorjan, Helal Uddin Ahmed, Renato D Alarcón, Kiyomi Arai, Sani Salihu Auwal, Michael Berk, Sarah Bjedov, Julio Bobes, Teresa Bobes-Bascaran, Julie Bourgin-Duchesnay, Cristina Ana Bredicean, Laurynas Bukelskis, Akaki Burkadze, Indira Indiana Cabrera Abud, Ruby Castilla-Puentes, Marcelo Cetkovich, Hector Colon-Rivera, Ricardo Corral, Carla Cortez-Vergara, Piirika Crepin, Domenico De Berardis, Sergio Zamora Delgado, David De Lucena, Avinash De Sousa, Ramona Di Stefano, Seetal Dodd, Livia Priyanka Elek, Anna Elissa, Berta Erdelyi-Hamza, Gamze Erzin, Martin J Etchevers, Peter Falkai, Adriana Farcas, Ilya Fedotov, Viktoriia Filatova, Nikolaos K Fountoulakis, Iryna Frankova, Francesco Franza, Pedro Frias, Tatiana Galako, Cristian J Garay, Leticia Garcia-Álvarez, Maria Paz García-Portilla, Xenia Gonda, Tomasz M Gondek, Daniela Morera González, Hilary Gould, Paolo Grandinetti, Arturo Grau, Violeta Groudeva, Michal Hagin, Takayuki Harada, Tasdik M Hasan, Nurul Azreen Hashim, Jan Hilbig, Sahadat Hossain, Rossitza Iakimova, Mona Ibrahim, Felicia Iftene, Yulia Ignatenko, Matias Irarrazaval, Zaliha Ismail, Jamila Ismayilova, Asaf Jakobs, Miro Jakovljević, Nenad Jakšić, Afzal Javed, Helin Yilmaz Kafali, Sagar Karia, Olga Kazakova, Doaa Khalifa, Olena Khaustova, Steve Koh, Svetlana Kopishinskaia, Korneliia Kosenko, Sotirios A Koupidis, Illes Kovacs, Barbara Kulig, Alisha Lalljee, Justine Liewig, Abdul Majid, Evgeniia Malashonkova, Khamelia Malik, Najma Iqbal Malik, Gulay Mammadzada, Bilvesh Mandalia, Donatella Marazziti, Darko Marčinko, Stephanie Martinez, Eimantas Matiekus, Gabriela Mejia, Roha Saeed Memon, Xarah Elenne Meza Martínez, Dalia Mickevičiūtė, Roumen Milev, Muftau Mohammed, Alejandro Molina-López, Petr Morozov, Nuru Suleiman Muhammad, Filip Mustač, Mika S Naor, Amira Nassieb, Alvydas Navickas, Tarek Okasha, Milena Pandova, Anca-Livia Panfil, Liliya Panteleeva, Ion Papava, Mikaella E Patsali, Alexey Pavlichenko, Bojana Pejuskovic, Mariana Pinto Da Costa, Mikhail Popkov, Dina Popovic, Nor Jannah Nasution Raduan, Francisca Vargas Ramírez, Elmars Rancans, Salmi Razali, Federico Rebok, Anna Rewekant, Elena Ninoska Reyes Flores, María Teresa Rivera-Encinas, Pilar Saiz, Manuel Sánchez de Carmona, David Saucedo Martínez, Jo Anne Saw, Görkem Saygili, Patricia Schneidereit, Bhumika Shah, Tomohiro Shirasaka, Ketevan Silagadze, Satti Sitanggang, Oleg Skugarevsky, Anna Spikina, Sridevi Sira Mahalingappa, Maria Stoyanova, Anna Szczegielniak, Simona Claudia Tamasan, Giuseppe Tavormina, Maurilio Giuseppe Maria Tavormina, Pavlos N Theodorakis, Mauricio Tohen, Eva Maria Tsapakis, Dina Tukhvatullina, Irfan Ullah, Ratnaraj Vaidya, Johann M Vega-Dienstmaier, Jelena Vrublevska, Olivera Vukovic, Olga Vysotska, Natalia Widiasih, Anna Yashikhina, Panagiotis E Prezerakos, Daria Smirnova
No abstract text is available yet for this article.
January 25, 2024: CNS Spectrums
#36
JOURNAL ARTICLE
Mohamed S M Elshikhawoda, Sohaib Jararaa, Steven H S Tan, Ahmed Hashim Ahmed Mohamed, Doaa Abdalaziz Salih Abdalaziz, Abdillahi Ahmed Roble, Mahmoud Okaz, Waseem Ahmad, Abdelrhman Elsanosi, Hassan Jararah
Background Stroke is a prevalent ailment that impacts a substantial number of individuals globally, resulting in both physical impairment and mortality. One of its major causes is carotid artery stenosis. The symptoms and degree of stenosis are key indications for carotid endarterectomy (CEA). In this study, we highlight the indications and outcomes of carotid endarterectomy in our center. Methods This is a descriptive, retrospective, observational study. Data of patients who underwent CEA at Glan Clwyd Hospital from January 2018 to January 2023 was retrieved...
December 2023: Curēus
#37
REVIEW
Mahmoud A Elrebehy, Ahmed I Abulsoud, Walaa A El-Dakroury, Sherif S Abdel Mageed, Shereen Saeid Elshaer, Doaa Fathi, Nehal I Rizk, Yasser M Moustafa, Mohammed S Elballal, Osama A Mohammed, Mustafa Ahmed Abdel-Reheim, Mohamed Bakr Zaki, Abdulla M A Mahmoud, Ahmed A Rashad, Eman S Sawan, Tohada M Al-Noshokaty, Sameh Saber, Ahmed S Doghish
Asthma is a diverse inflammatory illness affecting the respiratory passages, leading to breathing challenges, bouts of coughing and wheezing, and, in severe instances, significant deterioration in quality of life. Epigenetic regulation, which involves the control of gene expression through processes such as post-transcriptional modulation of microRNAs (miRNAs), plays a role in the evolution of various asthma subtypes. In immune-mediated diseases, miRNAs play a regulatory role in the behavior of cells that form the airway structure and those responsible for defense mechanisms in the bronchi and lungs...
January 19, 2024: Pathology, Research and Practice
#38
JOURNAL ARTICLE
Hanaa M El Maghraby, Hend Abdalla El-Sayed, Samia Hussein, Doaa Sh El Azawy, Osama Attia, Eman Elshahat Orabi, Yasmin Ahmed Fahmy
BACKGROUND: It has been interesting to compare the levels of antimicrobial resistance and the virulence characteristics of uropathogenic Escherichia coli (UPEC) strains of certain phylogenetic groups. The purpose of this study was to identify the frequency of phylogenetic groups, adhesin genes, antibiotic sensitivity patterns, and extended spectrum-lactamases (ESBLs) genes in hospital-acquired UPEC. METHODS: After UPEC isolation, the disc diffusion method was used to assess its susceptibility to antibiotics...
January 18, 2024: Molecular Biology Reports
#39
JOURNAL ARTICLE
Eslam M Abbass, Ali Khalil Ali, Ahmed F El-Farargy, Doaa R Abdel-Haleem, Safaa S Shaban
The exponential development of resistance to conventional chemical insecticides adds another important motive for the creation of novel insecticidal active agents. One of the keys to meeting this challenge is the exploration of novel classes of insecticidal molecules with different modes of action. Herein, a novel series of spiro pyrimidine derivatives was prepared using some green synthetic methodologies such as microwave irradiation, and sonication under ultrasound waves. Spiro pyrimidine aminonitrile 1 is a key starting material for the synthesis of targets 2-9 by reaction with different carbon electrophiles and nitrogen nucleophiles...
January 17, 2024: Scientific Reports
#40
JOURNAL ARTICLE
Basem Abd-Elhamed Rashad, Doaa K Ibrahim, Mahmoud I Gilany, Ahmed Sayed Abdelhamid, Wael Abdelfattah
Interconnected transmission systems are increasingly spreading out in HV networks to enhance system efficiency, decrease reserve capacity, and improve service reliability. However, the protection of multi-terminal lines against Broken Conductor Fault (BCF) imposes significant difficulties in such networks as the conventional distance relays cannot detect BCF, as the BCF is not associated with a significant increase in current or reduction in voltage Traditionally, the earth fault relays in transmission lines may detect such fault; Nonetheless, it suffers from a long delay time...
2024: PloS One
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