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Doaa ahmed

Ahmed El-Gendi, Mohamed El-Shafei, Doaa Emara
INTRODUCTION: In grade II acute cholecystitis patients presenting more than 72 h after onset of symptoms, we prospectively compared treatment with emergency (ELC) to delayed laparoscopic cholecystectomy performed 6 weeks after percutaneous transhepatic gallbladder drainage (PTGBD). METHODS: Four hundred ninety-five patients with acute cholecystitis were assessed for eligibility; 345 were excluded or declined to participate. One hundred fifty patients were treated after consent with either ELC or PTGBD...
October 24, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Md Dilshad Manzar, Wassilatul Zannat, M Ejaz Hussain, Seithikurippu R Pandi-Perumal, Ahmed S Bahammam, Doaa Barakat, Nwakile Izuchukwu Ojike, Awad Olaish, D Warren Spence
PURPOSE: To explore and validate the factor structure of the Pittsburgh Sleep Quality Index (PSQI) in the collegiate young adults. METHODS: Six hundred university students were initially contacted and invited to participate in a survey of their sleep experience and history. Of this preliminary sample 418 of the students (age = 20.92 ± 1.81 years, BMI = 23.30 ± 2.57 kg/m(2)) fulfilled the screening criteria and ultimately completed the Pittsburgh Sleep Quality Index (PSQI), a self-report survey of respondents' sleep habits and sleep quality...
2016: SpringerPlus
Abd El-Hamid Salah Al-Hamshary, Osama Saad El-Shaaer, Doaa Refaay Soliman, Ghada Mohamed El-Mashad, Ahmed Ibraheem Hussien
INTRODUCTION: High serum resistin levels are associated with the incidence of chronic kidney disease (CKD). The objectives of this study were to determine the serum concentrations of resistin in children that present with chronic renal failure (CRF) and end stage renal disease (ESRD), in order to examine the impact of hemodialysis (HD) on serum resistin levels, and to determine if a correlation exists between resistin and growth retardation in patients with CRF. METHODS: This case control study was undertaken in the pediatric hemodialysis unit of the Benha and Menoufia University hospitals from April 2014 to March 2015...
July 2016: Electronic Physician
Hamdy N El Tallawy, Wafaa Ma Farghaly, Tarek A Rageh, Ahmed O Saleh, Taha Ah Mestekawy, Manal Mm Darwish, Mohamed A Abd El Hamed, Anwar M Ali, Doaa M Mahmoud
A screening questionnaire is an important tool for early diagnosis of neurological disorders, and for epidemiological research. This screening instrument must be both feasible and valid. It must be accepted by the community and must be sensitive enough. So, the aim of this study was to prepare different Arabic screening questionnaires for screening different neurological disorders. This study was carried out in three stages. During the first stage, construction of separate questionnaires designed for screening the five major neurological disorders: cerebrovascular stroke, dementias, epilepsy, movement disorders, and muscle and neuromuscular disorders were done...
2016: Neuropsychiatric Disease and Treatment
Abeer Ahmed Kassem, Doaa Ahmed Elsayed Issa, Gehan Sherif Kotry, Ragwa Mohamed Farid
INTRODUCTION: Periodontal disease broadly defines group of conditions in which the supportive structure of the tooth (periodontium) is destroyed. Recent studies suggested that the anti-diabetic drug metformin hydrochloride (MF) has an osteogenic effect and is beneficial for the management of periodontitis. OBJECTIVE: Development of strong mucoadhesive multiple layer film loading small dose of MF for intra-pocket application. METHODOLOGY: Multiple layer film was developed by double casting followed by compression method...
September 2, 2016: Drug Development and Industrial Pharmacy
Rehab H Ashour, Mohamed-Ahdy Saad, Mohamed-Ahmed Sobh, Fatma Al-Husseiny, Mohamed Abouelkheir, Amal Awad, Doaa Elghannam, Hassan Abdel-Ghaffar, Mohamed Sobh
BACKGROUND: The paracrine and regenerative activities of mesenchymal stem cells (MSCs) may vary with different stem cell sources. The aim of the present study is to compare the effects of MSCs from different sources on acute kidney injury (AKI) induced by cisplatin and their influence on renal regeneration. METHODS: A single intraperitoneal injection of cisplatin (5 mg/kg) was used to induce AKI in 120 Sprague-Dawley rats. Rats were treated with either rat bone marrow stem cells (rBMSCs), human adipose tissue-derived stem cells (hADSCs), or human amniotic fluid-derived stem cells (hAFSCs)...
2016: Stem Cell Research & Therapy
Doaa Ahmed El-Setouhy, Alaa Abdel-Rahman Gamiel, Alia Abd El-Latif Badawi, Afaf Sayed Osman, Dina Ahmed Labib
CONTEXT: lornoxicam is a potent NSAID drug. It shows limited solubility in the gastric pH, delayed bioavailability and pharmacodynamic effects with aggravated gastric side effects (due to longer residence in the stomach wall). OBJECTIVE: to enhance dissolution of lornoxicam in the gastric fluid and expectedly absorption and pharmacological action; with less ulcerogenic effects. MATERIALS AND METHODS: formulation of immediate release (IR) lornoxicam liquitablets containing both liquid and solid release modulators (wetting agent, solubilizers and microenvironment pH modifiers)...
August 5, 2016: Pharmaceutical Development and Technology
Rasha Tarif Hamza, Alaa Youssef Ahmed, Doaa Gamal Rezk, Amira Ibrahim Hamed
BACKGROUND: Excessive use of fructose has been incriminated as a risk factor for hepatic steatosis. Procollagen type III N-terminal peptide (P3NP) is a marker for steatohepatitis. Thus, we aimed to assess fructose intake in obese children and its relation to nonalcoholic fatty liver disease (NAFLD) and P3NP. METHODS: Fifty-five obese children were compared to 30 controls. All were subjected to dietary fructose and anthropometric assessment, fasting blood sugar (FBS), fasting insulin (FI) and homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, uric acid, alanine aminotransferase (ALT), P3NP and abdominal ultrasound...
July 21, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Fatma Al-Husseiny, Mohamed Ahmed Sobh, Rehab H Ashour, Samah Foud, Tarek Medhat, Abdel-Hady El-Gilany, Doaa Elghannam, Hassan Abdel-Ghaffar, Mohamed-Ahdy Saad, Mohamed Sobh
BACKGROUND AND OBJECTIVES: Cisplatin is a nephrotoxic chemotherapeutic agent. So, preventive measures worth to be evaluated. Human amniotic fluid stem cells (hAFSCs) in prevention or amelioration of cisplatin-induced acute kidney injury (AKI) in Sprague-Dawley rates have been tested. METHODS: 80 Sprague-Dawley rats (250~300 g) were used and divided into 4 major groups, 20 rats each. Group I: Saline-injected group. Group II: Cisplatin-injected group (5 mg/kg I.P)...
May 30, 2016: International Journal of Stem Cells
Fatma M Elhusseini, Mohamed-Ahdy A A Saad, Nahla Anber, Doaa Elghannam, Mohamed-Ahmed Sobh, Aziza Alsayed, Sara El-Dusoky, Hussein Sheashaa, Hassan Abdel-Ghaffar, Mohamed Sobh
BACKGROUND/AIMS: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (ADMSCs) in prevention or amelioration of cisplatin induced acute kidney injury (AKI) in Sprague-Dawley rats. For this, we determined the kidney tissue level of oxidative stress markers in conjugation with a renal histopathological scoring system of both acute and chronic renal changes...
2016: Journal of Stem Cells & Regenerative Medicine
Joseph R Phillips, Abeer M Eissa, Doaa H Hewedi, Marjan Jahanshahi, Mohamed El-Gamal, Szabolcs Keri, Ahmed A Moustafa
Parkinson's disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing, speaking, and breathing. PD is a neurodegenerative disease, with dopaminergic neuronal loss occurring in the substantia nigra pars compacta, thus disrupting basal ganglia functions. This leads to downstream effects on other neurotransmitter systems such as glutamate, γ-aminobutyric acid, and serotonin...
June 30, 2016: Reviews in the Neurosciences
Ahmed Abd El Basset Abo El Ezz, Maher Ahmed Abd El Hafez, Doaa Mohamed El Amrousy, Ghada Abd El Momen Suliman
OBJECTIVE: Von Willebrand factor antigen (VWF-Ag) is proved to be a marker for pulmonary endothelial injury in acute lung injury (ALI). We aimed to evaluate the predictive value of VWF-Ag plasma levels in children with ALI. METHODS: Prospective controlled study included 40 children with ALI as a patient group, 40 healthy children as a control group. Plasma VWF Ag level was measured at days 1 and 3 in patient group and measured once for control group. RESULTS: The commonest cause of ALI was pneumonia (35%)...
June 30, 2016: Pediatric Pulmonology
Ahmed O Abdel-Zaher, Mostafa M Hamdy, Mahran S Abdel-Rahman, Doaa H Abd El-Hamid
The potential protective effect of citicoline on aluminum chloride-induced cognitive deficits was investigated in rats. In a Morris water maze, administration of aluminum chloride to rats for 90 days resulted in increased escape latency to reach the platform and decreased swimming speed in acquisition trials. Similarly, in probe trials, the time required to reach the hidden platform was increased and the time spent in the target quadrant was reduced. Also, administration of aluminum chloride to rats for 90 days increased the reference and working memory errors and time required to end the task in the radial arm maze...
May 13, 2016: Toxicology and Industrial Health
Ahmed A Abd-Elrahman, Mohamed A El Nabarawi, Doaa H Hassan, Amal A Taha
SBA-15 is used to enhance the bioavailability of poorly soluble ketoprofen (KP) through stabilization of its amorphous state. Additionally, the current work provides a complete in vitro and in vivo study on preformulated KP-SBA-15 sample and formulated KP-SBA-15 in hard gelatin capsule. Loading of KP was done by a novel method called immersion-rotavapor method. KP was quantified by extraction and thermal gravimetric analysis (TGA). Characterization of the loaded SBA-15 sample was done by high resolution transmission electron microscopy (HRTEM), small angle X-ray diffraction (SAXRD), nitrogen adsorption/desorption isotherms, differential scanning calorimetry (DSC), Fourier transform infrared (FT-IR) spectroscopy and dissolution profiles...
June 3, 2016: Drug Delivery
Doaa H Abdelaziz, Noha M Elhosseiny, Sahar A Khaleel, Nirmeen A Sabry, Ahmed S Attia, Manal H El-Sayed
BACKGROUND: The aim of the present study is to determine the correlation of hepatitis C virus (HCV) infection and polymorphisms in different genes with toxicity of either methotrexate (MTX) or 6-mercaptopurine (6-MP) administered to children with acute lymphoblastic leukemia (ALL). PROCEDURE: One hundred children with low-risk ALL, who were treated according to the St. Jude Total therapy XV, were recruited. The recruited children were receiving MTX and 6-MP during maintenance phase...
September 2016: Pediatric Blood & Cancer
Doaa Ahmed El-Setouhy, A B Ibrahim, Maha M Amin, Omneya M Khowessah, Eman S Elzanfaly
Haloperidol is a commonly prescribed antipsychotic drug currently administered as oral and injectable preparations. This study aimed to prepare haloperidol intranasal miniemulsion helpful for psychiatric emergencies and exhibiting lower systemic exposure and side effects associated with non-target site delivery. Haloperidol miniemulsions were successfully prepared by spontaneous emulsification adopting 2(3) factorial design. The effect of three independent variables at two levels each namely; oil type (Capmul®-Capryol™90), lipophilic emulsifier type (Span 20-Span 80) and HLB value (12-14) on globule size, PDI and percent locomotor activity inhibition in mice was evaluated...
September 20, 2016: European Journal of Pharmaceutical Sciences
Ahmed Fouad Kotb, Doaa Attia, Mohamed Mohie Hashad, Tamer Mohammed Abou Youssif, Nora Abdelkawy, Asmaa Ismail, Ahmed Elabbady, Mohamed Adel Atta
OBJECTIVE: There is a noticeable increase in the presentation of different types of urological malignancies at a younger age of presentation, in our institution. The objective of our study was to investigate cases presented with renal cell carcinoma, managed in the past 10 years for any possible epidemiological and cancer characteristics changes. METHODOLOGY: Retrospective data collection for cases managed by our institution in the time period (2002-2012) was done...
April 2016: International Journal of Health Sciences
Reem T Atawia, Ahmed Esmat, Doaa A Elsherbiny, Ebtehal El-Demerdash
This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg(-1) , 1:1 mixture with corn oil for 3 days increased serum alanine transaminase, aspartate transaminase, and alkaline phosphatase activities as well as total bilirubin, triglycerides and total cholesterol levels. This is in addition to the disrupted histological architecture in the CCl4 group...
March 1, 2016: Environmental Toxicology
Ola Zanaty, Shahira El Metainy, Doaa Abo Alia, Ahmed Medra
BACKGROUND: Temporomandibular joint (TMJ) ankylosis accompanied by mandibular micrognathia can severely obstruct a patient's upper airway. The obstructive sleep apnea and hypopnea syndrome (OSAHS) resulting from TMJ ankylosis and accompanied by mandibular micrognathia, can severely influence the patient's life. AIM: The aim of this study was to determine if there is a difference in Cormack and Lehane score before and after distraction osteogenesis in such patients, and to evaluate the airway changes and the respiratory outcome using polysomnography after mandibular distraction osteogenesis...
April 2016: Paediatric Anaesthesia
Mohamed A Youssef, Lobna Abdelsalam, Reem Abdelhameed Harfoush, Iman Mamdouh Talaat, Eman Elkattan, Abeer Mohey, Rana M A Abdella, Marwa Salah Farhan, Hany Ahmed Foad, Abeer Mostafa Elsayed, Naglaa A Elkinaai, Doaa Ghaith, Mohamed Elsayed Rashed, Mohamed Abd-El Ghafar, Yasser Khamis, Ahmed N Hosni
BACKGROUND: The association of human papillomavirus (HPV) with cervical cancer is well established. AIM: To investigate HPV genotype distribution and co-infection occurrence in cervical specimens from a group of Egyptian women. METHODS: A group of 152 women with and without cervical lesions were studied. All women had cervical cytology and HPV testing. They were classified according to cytology into those with normal cytology, with squamous intraepithelial lesions (SIL) and invasive squamous cell carcinoma (SCC)...
2016: Infectious Agents and Cancer
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