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https://www.readbyqxmd.com/read/27893677/impact-of-iron-deficiency-anemia-on-the-function-of-the-immune-system-in-children
#1
Tamer Hasan Hassan, Mohamed Ahmed Badr, Nehad Ahmed Karam, Marwa Zkaria, Hosam Fathy El Saadany, Doaa Mohamed Abdel Rahman, Doaa Abdallah Shahbah, Salah Mohamed Al Morshedy, Manar Fathy, Asmaa Mohamed Hosni Esh, Amal Mohamed Selim
The importance of iron deficiency as a public health problem is based ultimately on the seriousness of its consequences on health. The most extensively investigated consequences of iron deficiency involve work performance and immune function. The significance of the effects on work performance is generally accepted. In contrast, data on the influence of iron deficiency on immune function are often perceived as being confusing and contradictory.We aimed to evaluate the effect of iron deficiency anemia on humoral, cellular, nonspecific immunity, and also the effect on the cytokines that are the key factors of many immunologic steps...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27878630/diagnostic-and-prognostic-value-of-plasma-levels-of-cardiac-myosin-binding-protein-c-as-a-novel-biomarker-in-heart-failure
#2
Doaa El Amrousy, Hossam Hodeib, Ghada Suliman, Nahed Hablas, Eman Ramadan Salama, Ahmed Esam
Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 25 healthy children of matched age and sex as a control group. cMyBP-C plasma levels were measured in patients with HF at the time of admission and 1 month after treatment. Echocardiographic assessment was done for all children...
November 23, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27877029/comments-on-the-paper-efficacies-of-globus-pallidus-stimulation-and-subthalamic-nucleus-stimulation-for-advanced-parkinson-s-disease-a-meta-analysis-of-randomized-controlled-trials
#3
COMMENT
https://www.readbyqxmd.com/read/27860335/development-of-a-synthetic-tissue-engineered-3d-printed-bioceramic-based-bone-graft-with-homogenously-distributed-osteoblasts-and-mineralizing-bone-matrix-in-vitro
#4
Doaa Adel-Khattab, Francesca Giacomini, Renate Gildenhaar, Georg Berger, Cynthia Gomes, Ulf Linow, Martin Hardt, Barbara Peleska, Jens Günster, Michael Stiller, Alireza Houshmand, Khaled Abdel Ghaffar, Ahmed Gamal, Mohamed El-Mofty, Christine Knabe
Over the last decade there have been increasing efforts to develop 3D scaffolds for bone tissue engineering from bioactive ceramics with 3D printing emerging as a promising technology. The overall objective of the present study was to generate a tissue engineered synthetic bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro, thereby mimicking the advantageous properties of autogenous bone grafts and facilitating usage for reconstructing segmental discontinuity defects in vivo...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27823571/caffeine-the-forgotten-potential-for-parkinson-s-disease
#5
Ahmed Negida, Mohamed Elfil, Attia Attia, Eslam Farahat, Mohamed Gabr, Ahmed Essam, Hussein Ahmed, Doaa Attia
Parkinson's disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies. The literature suggests that caffeine play multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk of developing PD, especially in genetically susceptible patients. On the level of Lewy bodies' formation, caffeine binds to α-synuclein protein inducing conformational changes and preventing their aggregation...
November 6, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27802917/development-and-validation-of-lc-ms-ms-assay-for-the-simultaneous-determination-of-methotrexate-6-mercaptopurine-and-its-active-metabolite-6-thioguanine-in-plasma-of-children-with-acute-lymphoblastic-leukemia-correlation-with-genetic-polymorphism
#6
Medhat A Al-Ghobashy, Said A Hassan, Doaa H Abdelaziz, Noha M Elhosseiny, Nirmeen A Sabry, Ahmed S Attia, Manal H El-Sayed
Individualized therapy is a recent approach aiming to specify dosage regimen for each patient according to its genetic state. Cancer chemotherapy requires continuous monitoring of the plasma concentration levels of active forms of cytotoxic drugs and subsequent dose adjustment. In order to attain optimum therapeutic efficacy, correlation to pharmacogenetics data is crucial. In this study, a specific, accurate and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) has been developed for determination of methotrexate (MTX), 6-mercaptopurine (MP) and its metabolite 6-thioguanine nucleotide (TG) in human plasma...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27802428/effect-of-melatonin-on-telocytes-in-the-seminal-vesicle-of-the-soay-ram-an-immunohistochemical-ultrastructural-and-morphometrical-study
#7
Hanan H Abd-Elhafeez, Doaa M Mokhtar, Ahmed H S Hassan
Telocytes (TCs) are a special type of interstitial cell with characteristic cellular processes that are described in many organs. The current study aimed to investigate TCs in seminal vesicles of the Soay ram responding to melatonin treatment during the nonbreeding season by conventional immunohistochemical stains, and to detect the ultrastructural and morphometrical changes of TCs. TCs in the control group showed a broad range of staining affinity and also reacted positively to CD117/c-kit, CD34, desmin, S-100 protein, and progesterone and estrogen receptors alpha, while after melatonin treatment a strong reaction against these 6 antibodies was recorded...
November 2, 2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27798546/evaluation-of-early-corticosteroid-therapy-in-management-of-pediatric-septic-shock-in-pediatric-intensive-care-patients-a-randomized-clinical-study
#8
Ahmed El-Nawawy, Doaa Khater, Heba Omar, Yasser Wali
BACKGROUND: Septic shock is a major healthcare problem. Adrenal insufficiency in children with septic shock is a recognized complication, yet is controversial regarding its management and effect on mortality. According to the current guidelines, children with risk factors for adrenal insufficiency should receive a stress dose of steroids in step 3 of treatment. This study aimed to evaluate and compare early corticosteroid therapy with the traditional use of steroids among pediatric septic shock patients...
October 25, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27778253/emergency-versus-delayed-cholecystectomy-after-percutaneous-transhepatic-gallbladder-drainage-in-grade-ii-acute-cholecystitis-patients
#9
Ahmed El-Gendi, Mohamed El-Shafei, Doaa Emara
INTRODUCTION: In grade II acute cholecystitis patients presenting more than 72 h after onset of symptoms, we prospectively compared treatment with emergency (ELC) to delayed laparoscopic cholecystectomy performed 6 weeks after percutaneous transhepatic gallbladder drainage (PTGBD). METHODS: Four hundred ninety-five patients with acute cholecystitis were assessed for eligibility; 345 were excluded or declined to participate. One hundred fifty patients were treated after consent with either ELC or PTGBD...
October 24, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27652123/dimensionality-of-the-pittsburgh-sleep-quality-index-in-the-collegiate-young-adults
#10
Md Dilshad Manzar, Wassilatul Zannat, M Ejaz Hussain, Seithikurippu R Pandi-Perumal, Ahmed S Bahammam, Doaa Barakat, Nwakile Izuchukwu Ojike, Awad Olaish, D Warren Spence
PURPOSE: To explore and validate the factor structure of the Pittsburgh Sleep Quality Index (PSQI) in the collegiate young adults. METHODS: Six hundred university students were initially contacted and invited to participate in a survey of their sleep experience and history. Of this preliminary sample 418 of the students (age = 20.92 ± 1.81 years, BMI = 23.30 ± 2.57 kg/m(2)) fulfilled the screening criteria and ultimately completed the Pittsburgh Sleep Quality Index (PSQI), a self-report survey of respondents' sleep habits and sleep quality...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27648184/evaluation-of-serum-resistin-in-children-with-chronic-renal-failure-undergoing-hemodialysis
#11
Abd El-Hamid Salah Al-Hamshary, Osama Saad El-Shaaer, Doaa Refaay Soliman, Ghada Mohamed El-Mashad, Ahmed Ibraheem Hussien
INTRODUCTION: High serum resistin levels are associated with the incidence of chronic kidney disease (CKD). The objectives of this study were to determine the serum concentrations of resistin in children that present with chronic renal failure (CRF) and end stage renal disease (ESRD), in order to examine the impact of hemodialysis (HD) on serum resistin levels, and to determine if a correlation exists between resistin and growth retardation in patients with CRF. METHODS: This case control study was undertaken in the pediatric hemodialysis unit of the Benha and Menoufia University hospitals from April 2014 to March 2015...
July 2016: Electronic Physician
https://www.readbyqxmd.com/read/27621635/construction-of-standardized-arabic-questionnaires-for-screening-neurological-disorders-dementia-stroke-epilepsy-movement-disorders-muscle-and-neuromuscular-junction-disorders
#12
Hamdy N El Tallawy, Wafaa Ma Farghaly, Tarek A Rageh, Ahmed O Saleh, Taha Ah Mestekawy, Manal Mm Darwish, Mohamed A Abd El Hamed, Anwar M Ali, Doaa M Mahmoud
A screening questionnaire is an important tool for early diagnosis of neurological disorders, and for epidemiological research. This screening instrument must be both feasible and valid. It must be accepted by the community and must be sensitive enough. So, the aim of this study was to prepare different Arabic screening questionnaires for screening different neurological disorders. This study was carried out in three stages. During the first stage, construction of separate questionnaires designed for screening the five major neurological disorders: cerebrovascular stroke, dementias, epilepsy, movement disorders, and muscle and neuromuscular disorders were done...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27589817/thiolated-alginate-based-multiple-layer-mucoadhesive-films-of-metformin-forintra-pocket-local-delivery-in-vitro-characterization-and-clinical-assessment
#13
Abeer Ahmed Kassem, Doaa Ahmed Elsayed Issa, Gehan Sherif Kotry, Ragwa Mohamed Farid
INTRODUCTION: Periodontal disease broadly defines group of conditions in which the supportive structure of the tooth (periodontium) is destroyed. Recent studies suggested that the anti-diabetic drug metformin hydrochloride (MF) has an osteogenic effect and is beneficial for the management of periodontitis. OBJECTIVE: Development of strong mucoadhesive multiple layer film loading small dose of MF for intra-pocket application. METHODOLOGY: Multiple layer film was developed by double casting followed by compression method...
September 2, 2016: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/27585525/comparative-study-of-allogenic-and-xenogeneic-mesenchymal-stem-cells-on-cisplatin-induced-acute-kidney-injury-in-sprague-dawley-rats
#14
Rehab H Ashour, Mohamed-Ahdy Saad, Mohamed-Ahmed Sobh, Fatma Al-Husseiny, Mohamed Abouelkheir, Amal Awad, Doaa Elghannam, Hassan Abdel-Ghaffar, Mohamed Sobh
BACKGROUND: The paracrine and regenerative activities of mesenchymal stem cells (MSCs) may vary with different stem cell sources. The aim of the present study is to compare the effects of MSCs from different sources on acute kidney injury (AKI) induced by cisplatin and their influence on renal regeneration. METHODS: A single intraperitoneal injection of cisplatin (5 mg/kg) was used to induce AKI in 120 Sprague-Dawley rats. Rats were treated with either rat bone marrow stem cells (rBMSCs), human adipose tissue-derived stem cells (hADSCs), or human amniotic fluid-derived stem cells (hAFSCs)...
September 1, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27494155/comparative-study-on-the-in-vitro-performance-of-blister-molded-and-conventional-lornoxicam-immediate-release-liquitablets-accelerated-stability-study-and-anti-inflammatory-and-ulcerogenic-effects
#15
Doaa Ahmed El-Setouhy, Alaa Abdel-Rahman Gamiel, Alia Abd El-Latif Badawi, Afaf Sayed Osman, Dina Ahmed Labib
CONTEXT: lornoxicam is a potent NSAID drug. It shows limited solubility in the gastric pH, delayed bioavailability and pharmacodynamic effects with aggravated gastric side effects (due to longer residence in the stomach wall). OBJECTIVE: to enhance dissolution of lornoxicam in the gastric fluid and expectedly absorption and pharmacological action; with less ulcerogenic effects. MATERIALS AND METHODS: formulation of immediate release (IR) lornoxicam liquitablets containing both liquid and solid release modulators (wetting agent, solubilizers and microenvironment pH modifiers)...
August 5, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27442361/dietary-fructose-intake-in-obese-children-and-adolescents-relation-to-procollagen-type-iii-n-terminal-peptide-p3np-and-non-alcoholic-fatty-liver-disease
#16
Rasha Tarif Hamza, Alaa Youssef Ahmed, Doaa Gamal Rezk, Amira Ibrahim Hamed
BACKGROUND: Excessive use of fructose has been incriminated as a risk factor for hepatic steatosis. Procollagen type III N-terminal peptide (P3NP) is a marker for steatohepatitis. Thus, we aimed to assess fructose intake in obese children and its relation to nonalcoholic fatty liver disease (NAFLD) and P3NP. METHODS: Fifty-five obese children were compared to 30 controls. All were subjected to dietary fructose and anthropometric assessment, fasting blood sugar (FBS), fasting insulin (FI) and homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, uric acid, alanine aminotransferase (ALT), P3NP and abdominal ultrasound...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27426088/amniotic-fluid-derived-mesenchymal-stem-cells-cut-short-the-acuteness-of-cisplatin-induced-nephrotoxicity-in-sprague-dawley-rats
#17
Fatma Al-Husseiny, Mohamed Ahmed Sobh, Rehab H Ashour, Samah Foud, Tarek Medhat, Abdel-Hady El-Gilany, Doaa Elghannam, Hassan Abdel-Ghaffar, Mohamed-Ahdy Saad, Mohamed Sobh
BACKGROUND AND OBJECTIVES: Cisplatin is a nephrotoxic chemotherapeutic agent. So, preventive measures worth to be evaluated. Human amniotic fluid stem cells (hAFSCs) in prevention or amelioration of cisplatin-induced acute kidney injury (AKI) in Sprague-Dawley rates have been tested. METHODS: 80 Sprague-Dawley rats (250~300 g) were used and divided into 4 major groups, 20 rats each. Group I: Saline-injected group. Group II: Cisplatin-injected group (5 mg/kg I.P)...
May 30, 2016: International Journal of Stem Cells
https://www.readbyqxmd.com/read/27398000/long-term-study-of-protective-mechanisms-of-human-adipose-derived-mesenchymal-stem-cells-on-cisplatin-induced-kidney-injury-in-sprague-dawley-rats
#18
Fatma M Elhusseini, Mohamed-Ahdy A A Saad, Nahla Anber, Doaa Elghannam, Mohamed-Ahmed Sobh, Aziza Alsayed, Sara El-Dusoky, Hussein Sheashaa, Hassan Abdel-Ghaffar, Mohamed Sobh
BACKGROUND/AIMS: Long-term evaluation of cisplatin induced nephrotoxicity and the probable renal protective activities of stem cells are lacking up until now. We evaluated the early and long-term role of human adipose derived mesenchymal stem cells (ADMSCs) in prevention or amelioration of cisplatin induced acute kidney injury (AKI) in Sprague-Dawley rats. For this, we determined the kidney tissue level of oxidative stress markers in conjugation with a renal histopathological scoring system of both acute and chronic renal changes...
2016: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/27362959/neural-substrates-and-potential-treatments-for-levodopa-induced-dyskinesias-in-parkinson-s-disease
#19
Joseph R Phillips, Abeer M Eissa, Doaa H Hewedi, Marjan Jahanshahi, Mohamed El-Gamal, Szabolcs Keri, Ahmed A Moustafa
Parkinson's disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing, speaking, and breathing. PD is a neurodegenerative disease, with dopaminergic neuronal loss occurring in the substantia nigra pars compacta, thus disrupting basal ganglia functions. This leads to downstream effects on other neurotransmitter systems such as glutamate, γ-aminobutyric acid, and serotonin...
June 30, 2016: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/27362747/the-predictive-value-of-von-willebrand-factor-antigen-plasma-levels-in-children-with-acute-lung-injury
#20
Ahmed Abd El Basset Abo El Ezz, Maher Ahmed Abd El Hafez, Doaa Mohamed El Amrousy, Ghada Abd El Momen Suliman
OBJECTIVE: Von Willebrand factor antigen (VWF-Ag) is proved to be a marker for pulmonary endothelial injury in acute lung injury (ALI). We aimed to evaluate the predictive value of VWF-Ag plasma levels in children with ALI. METHODS: Prospective controlled study included 40 children with ALI as a patient group, 40 healthy children as a control group. Plasma VWF Ag level was measured at days 1 and 3 in patient group and measured once for control group. RESULTS: The commonest cause of ALI was pneumonia (35%)...
June 30, 2016: Pediatric Pulmonology
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