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Doaa ahmed

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https://www.readbyqxmd.com/read/29684708/structural-based-design-synthesis-and-antitumor-activity-of-novel-alloxazine-analogues-with-potential-selective-kinase-inhibition
#1
Waleed H Malki, Ahmed M Gouda, Hamdy E A Ali, Rabaa Al-Rousan, Doaa Samaha, Ashraf N Abdalla, Juan Bustamante, Zakaria Y Abd Elmageed, Hamed I Ali
Protein kinases are promising therapeutic targets for cancer therapy. Here, we applied multiple approaches to optimize the potency and selectivity of our reported alloxazine scaffold. Flexible moieties at position 2 of the hetero-tricyclic system were incorporated to fit into the ATP binding site and extend to the adjacent allosteric site and selectively inhibit protein kinases. This design led to potential selective inhibition of ABL1, CDK1/Cyclin A1, FAK, and SRC kinase by 30-59%. Cytotoxicity was improved by ∼50 times for the optimized lead (10b; IC50  = 40 nM) against breast cancer (MCF-7) cells...
April 17, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29628556/comparison-of-three-different-concentrations-of-levobupivacaine-for-epidural-labor-analgesia-clinical-effect-and-pharmacokinetic-profile
#2
Ahmed Mostafa El-Shaarawy, Mohamed S Asfour, Doaa A Rashwan, Mahmoud M Amer, Shahira F El-Menshawe, Mohammed H Elkomy
Background: The aim is to compare the clinical effect of three different concentrations of levobupivacaine (0.25%, 0.125%, and 0.0625%) on the sensory and motor block characteristics and mode of delivery during epidural labor analgesia. We also studied the pharmacokinetic profile of the three concentrations during labor. Materials and Methods: Sixty pregnant females undergoing normal vaginal delivery under epidural analgesia were divided into three groups according to the concentration of levobupivacaine used...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29610945/effect-of-maternal-obesity-on-labor-induction-in-postdate-pregnancy
#3
Ahmed M Maged, Ali M El-Semary, Heba M Marie, Doaa S Belal, Ayman Hany, Mohammad A Taymour, Eman F Omran, Sahar M Y Elbaradie, Mohamed A Kamal Mohamed
OBJECTIVE: To test the hypothesis that there is a higher rate of unsuccessful induction of labor (IOL) in post-term obese pregnant women compared to non-obese ones. METHODS: In this prospective cohort study, 144 obese (BMI > 30) and 144 non-obese (BMI < 29.9) post-term (> 41 weeks) pregnant women were recruited. IOL was done by misoprostol or amniotomy and oxytocin infusion according to the Bishop score. Comparison of percentage of failed IOL in both groups (primary outcome) was performed by the Chi-test...
April 2, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29531595/utility-of-tissue-inhibitor-metalloproteinase-1-and-osteopontin-as-prospective-biomarkers-of-early-cardiovascular-complications-in-type-2-diabetes
#4
Doaa Samir Salah El-Din, Ahmed Ibrahim Amin, Ahmed Osman Egiza
AIM: This work investigated associations between tissue inhibitor metalloproteinase-1 and diabetic cardiovascular diseases in type 2 diabetic patients; also it investigated the role of osteopontin in the diagnosis of type 2 cardiovascular diabetes complications. SUBJECTS AND METHODS: These were examined on eighty subjects, divided into three groups as follows: twenty volunteer healthy control subjects, thirty type 2 diabetes mellitus (DM) patients, and thirty cardiovascular, diabetic patients...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29498941/ultrasound-guided-laryngeal-air-column-width-difference-as-a-new-predictor-for-postextubation-stridor-in-children
#5
Doaa El Amrousy, Mohamed Elkashlan, Nagat Elshmaa, Ahmed Ragab
OBJECTIVES: To assess the efficacy of ultrasound-guided laryngeal air column width difference in predicting postextubation stridor in children. DESIGN: Prospective observational study. SETTING: Single, tertiary care pediatric hospital. PATIENTS: This study was carried out at PICU and surgical ICU, Tanta University Hospital on 400 ventilated children between January 2015 and May 2017. Patients who received mechanical ventilation and met criteria for a weaning trial were included...
March 1, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29439618/effect-of-prolonged-gnrh-agonist-downregulation-on-icsi-outcome-in-patients-with-endometriomas-of-less-than-5-cm-a-randomized-controlled-trial
#6
Ahmed Mohamed Maged, Hamsa Rashwan, Maryam Mahmood, Akmal El-Mazny, Mona Farouk, Doaa S Belal, Heba M Marie
OBJECTIVE: To evaluate the effect of prolonged Gonadotropin releasing hormone (GnRH) agonist downregulation in patients with endometriomas of less than 5 cm on the outcome of the proceeding Intracytoplasmic sperm injection (ICSI) trial. METHODS: In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups. Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29421812/serum-soluble-interleukin-2-receptor-level-as-a-marker-of-acute-rejection-in-pediatric-kidney-transplant-recipients
#7
Amal M Hagras, Doaa M Salah, Dina H Ahmed, Omnia K Abd Elaal, Hany Ahmed Fouad Elghobary, Fatina I Fadel
BACKGROUND: Despite advances in immunosuppression, acute allograft rejection remains one of the key factors affecting patient and graft survival in pediatric kidney transplantation. The aim of the study is to evaluate the role of serum soluble IL2 receptor (sIL2R) level as a noninvasive assessment parameter of acute rejection (AR). METHOD: Serum sIL2R level was measured (using enzyme-linked immune-sorbent assay technique) in 60 pediatric kidney transplant recipients (30 recipients with AR and 30 transplant recipients with stable graft function)...
February 8, 2018: Nephron
https://www.readbyqxmd.com/read/29397017/steroid-therapy-in-children-with-fulminant-hepatitis-a
#8
Haidy Mohammed Zakaria, Tahany Abdel-Hamid Salem, Hanaa Ahmed El-Araby, Rawan Mohammed Salama, Doaa Yousry Elbadry, Ahmad Mohamed Sira, Mohammed Abdul-Hafeez Ali, Menan El-Sayed Salem, Basma Mahmoud Abd-Alaaty, Shaimaa Samy Goda, Sara Mohammed Eltaras, Fatma Omar Khalil, Sahar Shahein Abou-Zeinah, Mostafa Mohamed Sira
Fulminant hepatic failure is a life-threatening disease. Hepatitis A virus (HAV) can cause fulminant hepatic failure and death in about 0.2% of cases. Extensive destruction of infected hepatocytes by immune-mediated lysis is thought to be the cause. We aimed to evaluate the use of steroid therapy in children with fulminant HAV. This study included 33 children with fulminant HAV in two groups. Steroid group; comprised of 18 children who received prednisolone (1 mg/kg/d) or its equivalent dose of methylprednisolone and the non-steroid group; comprised another 15 children who did not receive steroid therapy...
February 3, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29367929/case-report-of-human-urinary-myiasis-caused-by-clogmia-albipunctata-diptera-psychodidae-with-morphological-description-of-larva-and-pupa
#9
Nadia Ali El-Dib, Wegdan Mohamed Abd El Wahab, Doaa Ahmed Hamdy, Mona Ibrahim Ali
Background: Urinary myiasis is a form of myiasis caused mainly by larvae of Fannia scalaris, Musca, Sarcophaga, Lucilia, Wohlfahrtia, Calliphora, and rarely by Eristalis and Clogmia albipunctata. Methods: This report presents a case of female patient complaining of dysuria and frequency of micturition associated with intermittent passage of small, motile, dark-colored worm-like organisms in urine. She was a married housewife aged 24 years old referred from the Tropical Outpatient Clinic of Beni-Suef University Hospital, Egypt...
December 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29346268/effect-of-novel-quercetin-titanium-dioxide-decorated-multi-walled-carbon-nanotubes-nanocomposite-on-bacillus-subtilis-biofilm-development
#10
Diana S Raie, Eisha Mhatre, Doaa S El-Desouki, Ahmed Labena, Gamal El-Ghannam, Laila A Farahat, Tareq Youssef, Wolfgang Fritzsche, Ákos T Kovács
The present work was targeted to design a surface against cell seeding and adhering of bacteria, Bacillus subtilis . A multi-walled carbon nanotube/titanium dioxide nano-power was produced via simple mixing of carbon nanotube and titanium dioxide nanoparticles during the sol-gel process followed by heat treatment. Successfully, quercetin was immobilized on the nanocomposite via physical adsorption to form a quercetin/multi-walled carbon nanotube/titanium dioxide nanocomposite. The adhesion of bacteria on the coated-slides was verified after 24 h using confocal laser-scanning microscopy...
January 18, 2018: Materials
https://www.readbyqxmd.com/read/29334907/hemodynamic-effects-of-lateral-tilt-before-and-after-spinal-anesthesia-during-cesarean-delivery-an-observational-study
#11
Ahmed Hasanin, Remoon Soryal, Tarek Kaddah, Sabah Abdel Raouf, Yaser Abdelwahab, Khaled Elshafaei, Mohamed Elsayad, Bassant Abdelhamid, Reham Fouad, Doaa Mahmoud, Yasmin Hassabelnaby
BACKGROUND: Post-spinal hypotension is a common maternal complication during cesarean delivery. Aortocaval compression by the gravid uterus has been assumed as a precipitating factor for post-spinal hypotension. The role of left lateral tilting position in improving maternal cardiac output after subarachnoid block (SAB) is unclear. The aim of this work is to investigate the effect of left lateral tilting on maternal hemodynamics after SAB. METHODS: A prospective observational study was conducted including 105 full term pregnant women scheduled for cesarean delivery...
January 15, 2018: BMC Anesthesiology
https://www.readbyqxmd.com/read/29299784/religiosity-and-telomere-length-in-colorectal-cancer-patients-in-saudi-arabia
#12
Mahmoud Shaheen Al Ahwal, Faten Al Zaben, Mohammad Gamal Sehlo, Doaa Ahmed Khalifa, Harold G Koenig
Numerous studies have reported a significant relationship between psychological stress, depression, and telomere length (TL), an indicator of cellular lifespan. Religious involvement, which is associated with lower levels of stress and depression, has also recently been related to TL. To our knowledge, this relationship has not yet been examined in Muslims, colorectal cancer patients, cancer patients more generally, or any population outside the USA. A convenience sample of 50 colorectal patients was recruited from hospital-based oncology clinics in Jeddah, Saudi Arabia...
April 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29273932/treatment-of-gigantomastia-using-a-medial-lateral-bipedicle-reduction-mammoplasty-the-role-of-doppler-assisted-preoperative-perforator-identification
#13
Nader Gomaa Elmelegy, Mohamed Saad Sadaka, Ahmed M Hegazy, Doaa E Abdeldaim
The purpose of this study is to introduce a breast reduction technique designed to reduce the incidence of postoperative nipple-areola complex ischemia and necrosis following reduction mammoplasty, while at the same time allowing all the other goals of breast reduction to be realized. This is achieved through preoperative detection of perforating vessels supplying the nipple-areola complex using a hand-held Doppler. The horizontally based parenchymal pedicle is designed to include these perforators whether originating from the internal mammary artery, lateral thoracic artery or both...
February 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29241944/fracture-resistance-and-failure-modes-of-polymer-infiltrated-ceramic-endocrown-restorations-with-variations-in-margin-design-and-occlusal-thickness
#14
Doaa Taha, Sebastian Spintzyk, Christine Schille, Ahmed Sabet, Marwa Wahsh, Tarek Salah, Jürgen Geis-Gerstorfer
PURPOSE: The purpose of this in vitro study was to assess the effect of varying the margin designs and the occlusal thicknesses on the fracture resistance and mode of failures of endodontically treated teeth restored with polymer infiltrated ceramic endocrown restorations. METHODS: Root canal treated mandibular molars were divided into four groups (n=8) and were prepared to receive Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) fabricated polymer infiltrated ceramic endocrowns (ENAMIC blocks)...
December 11, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29224196/diagnostic-accuracy-of-posterior-cervical-angle-and-cervical-length-in-the-prediction-of-successful-induction-of-labor
#15
Akram M Al-Adwy, Sherin M Sobh, Doaa S Belal, Eman F Omran, Amr Hassan, Ahmed H Saad, Mai M Afifi, Adel M Nada
OBJECTIVE: To determine the accuracy of the posterior cervical angle (PCA) compared with the cervical length and the Bishop score in predicting the outcome of induction of labor (IOL). METHODS: The present prospective observational study included IOL candidates who had their PCA and cervical length assessed by transvaginal ultrasonography and the Bishop score at the Obstetrics and Gynecology Department, Kasr El-Aini Hospital, Cairo University, Cairo, Egypt, between April 1 and July 31, 2017...
April 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29219628/penetration-enhancer-containing-spanlastics-pecss-for-transdermal-delivery-of-haloperidol-in-vitro-characterization-ex-vivo-permeation-and-in-vivo-biodistribution-studies
#16
Abdurrahman M Fahmy, Doaa Ahmed El-Setouhy, Ahmed B Ibrahim, Basant A Habib, Saadia A Tayel, Noha A Bayoumi
Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at developing Hal-loaded penetration enhancer-containing spanlastics (PECSs) to increase transdermal permeation of Hal with sustained release. PECSs were successfully prepared using ethanol injection method showing reasonable values of percentage entrapment efficiency, particle size, polydispersity index and zeta potential. The statistical analysis of the ex vivo permeation parameters led to the choice of F1L - made of Span® 60 and Tween® 80 at the weight ratio of 4:1 along with 1% w/v Labrasol® - as the selected formula (SF)...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29199635/melatonin-elicits-stimulatory-action-on-the-adrenal-gland-of-soay-ram-morphometrical-immunohistochemical-and-ultrastructural-study
#17
Doaa M Mokhtar, Manal T Hussein, Ahmed H S Hassan
Endogenous melatonin is a hormone secreted by pineal gland; it has several roles in metabolism, reproduction, and remarkable antioxidant properties. Studies on the melatonin effect on the adrenal glands which are important endocrine organs, controlling essential physiological functions, are still deficient. In this study, we attempted to investigate the effect of exogenous melatonin treatment on the adrenal cortex and medulla using several approaches. Adrenal glands of 15 Soay ram were examined to detect the effect of melatonin treatment...
December 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29196978/the-role-of-soluble-epoxide-hydrolase-enzyme-on-daunorubicin-mediated-cardiotoxicity
#18
Zaid H Maayah, Ghada Abdelhamid, Osama H Elshenawy, Ahmed A El-Sherbeni, Hassan N Althurwi, Erica McGinn, Doaa Dawood, Ahmad H Alammari, Ayman O S El-Kadi
Several studies have demonstrated the role of cytochrome P450 (CYP) and its associated arachidonic acid (AA) metabolites in the anthracyclines-induced cardiac toxicity. However, the ability of daunorubicin (DNR) to induce cardiotoxicity through the modulation of CYP and its associated AA metabolites has not been investigated yet. Therefore, we hypothesized that DNR-induced cardiotoxicity is mediated through the induction of cardiotoxic hydroxyeicosatetraenoic acids and/or the inhibition of cardioprotctive epoxyeicosatrienoic acids (EETs)...
December 1, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29184438/efficacy-of-local-dexmedetomidine-add-on-for-spermatic-cord-block-anesthesia-in-patients-undergoing-intrascrotal-surgeries-randomized-controlled-multicenter-clinical-trial
#19
Diab Fuad Hetta, Emad E Kamal, Ali M Mahran, Doaa G Ahmed, Abdelraheem Elawamy, Abdelraouf Ms Abdelraouf
Study objective: The objective of this study was to evaluate the effect of adding dexmedetomidine (DEX) to bupivacaine on the quality of spermatic cord block anesthesia and postoperative analgesia. Design: This is a randomized, double-blind study. Setting: This study was performed in an educational and research hospital. Patients: One hundred twenty adult males were scheduled for intrascrotal surgeries. Interventions: Patients were divided into two groups: group B received 10 mL of bupivacaine 0...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29184360/serological-investigation-of-some-important-rna-viruses-affecting-sheep-and-goats-in-giza-and-beni-suef-governorates-in-egypt
#20
Mohamed Abd El-Fatah Mahmoud, Mohamed Karam Elbayoumy, Doaa Sedky, Sahar Ahmed
Aim: The aim of this study was to investigate the seroprevalence of antibodies against foot and mouth disease (FMD), Peste des Petits ruminants (PPR), and bluetongue (BT) in sheep and goats within Giza and Beni-Suef governorates at the second half of 2016. Materials and Methods: A total of 300 animals (sheep and goats) randomly selected from small stocks with no history of previous vaccination against FMD virus (FMDV), PPR, or BT viruses (BTV) and examined with competitive enzyme-linked immunosorbent assay for detection of FMD-non-structural protein, PPR, and BT antibodies...
October 2017: Veterinary World
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