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https://www.readbyqxmd.com/read/28516410/silymarin-loaded-eudragit-nanoparticles-formulation-characterization-and-hepatoprotective-and-toxicity-evaluation
#1
Amira E El-Nahas, Ahmed N Allam, Doaa A Abdelmonsif, Amal H El-Kamel
The objectives of this study were to formulate, characterize silymarin-loaded Eudragit nanoparticles (SNPs) and evaluate their hepatoprotective and cytotoxic effects after oral administration. SNPs were prepared by nanoprecipitation technique and were evaluated for particle size, entrapment efficiency, TEM, solid-state characterization, and in vitro drug release. The hepatoprotective activity was evaluated after oral administration of selected SNPs in carbon tetrachloride-intoxicated rats. Potential in vivo acute cytotoxicity study was also assessed...
May 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28507632/visfatin-versus-flow-mediated-dilatation-as-a-marker-of-endothelial-dysfunction-in-pediatric-renal-transplant-recipients
#2
Fatina Fadel, Hafez M Bazraa, Safaa M Abdelrahman, Mohamed Gamal Shouman, Marwa Khaled Sayed, Doaa Mohamed Salah, Aliaa Ahmed Wahby, Heba F Elgebaly
BACKGROUND: Renal transplantation (RTx) is the treatment of choice for paediatric end-stage renal disease (ESRD). A major cause of morbidity and mortality after RTx is cardiovascular disease. Independent predictors of cardiovascular events were shown to constitute an endothelial dysfunction (ED). This study aims to evaluate Visfatin serum level in comparison to brachial artery flow-mediated dilatation (FMD) as a marker of endothelial dysfunction in paediatric RTx recipients. METHODS: Visfatin serum level has been evaluated in 30 patients on regular hemodialysis (HD), 36 patients post-RTx and 30 controls as a measure for ED, and has been compared to brachial artery FMD...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28507630/relationship-between-gait-parameters-and-postural-stability-in-early-and-late-parkinson-s-disease-and-visual-feedback-based-balance-training-effects
#3
Mohieldin M Ahmed, Douaa M Mosalem, Aziz K Alfeeli, Ayyoub B Baqer, Doaa Youssry Soliman
BACKGROUND: Gait disorders or postural instability has been done before. However, lack of reviews has addressed the relation between gait and postural stability in Parkinson's disease (PD). AIM: The aim was to evaluate the relation between gait parameters and postural stability in early and late stages of PD. MATERIALS AND METHODS: The forty-one idiopathic PD patients were divided into two groups into a group (A) considered as early PD and group (B) considered as late ambulant PD...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28497191/evaluation-of-the-coronary-circulation-and-calcification-in-children-on-regular-hemodialysis
#4
Mohammed Al-Biltagi, Maher Ahmed Abd ElHafez, Doaa Mohamed El Amrousy, Mohamed El-Gamasy, Hesham El-Serogy
BACKGROUND: The objective of this study was to evaluate the coronary circulation and calcification in children with end-stage renal disease (ESRD) on hemodialysis. METHODS: A total of 50 children with ESRD and 50 healthy controls were enrolled in the study. Cardiac functions and coronary blood flow were evaluated with conventional and tissue Doppler echocardiography. Coronary artery calcification (CAC) was evaluated using high-resolution multidetector computed tomography (CT)...
May 11, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28244059/medical-errors-in-neonatal-intensive-care-unit-at-benha-university-hospital-egypt
#5
REVIEW
Ahmed N El-Shazly, Mahmoud A Al-Azzouny, Doaa R Soliman, Neveen T Abed, Sameh S Attia
This study was conducted in the neonatal intensive care unit of Benha University Hospital, Egypt from 1 August 2012 to the 31 January 2013 to identify medical errors and to determine the risk factors and consequences of these errors. Errors were detected by follow-up of neonates and review of reports including nursing followup sheets, resident progression notes and investigation reports. We detected 3819 errors that affected 97% of neonates. Types of errors included 403 medication errors (10.55% of total errors), 652 errors in daily routine procedures (17...
February 21, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/28235529/dexmedetomidine-decreases-the-required-amount-of-bupivacaine-for-ultrasound-guided-transversus-abdominis-plane-block-in-pediatrics-patients-a-randomized-study
#6
Rehab Abdel Raof, Shahira Ahmed El Metainy, Doaa Abou Alia, Moataza Abdel Wahab
BACKGROUND: The effect of dexmedetomidine on the potency of bupivacaine for transversus abdominis plane (TAP) block in pediatric patients has not been investigated. STUDY OBJECTIVE: The primary objective of this study was to assess the effectiveness of dexmedetomidine to decrease the concentration of bupivacaine needed for analgesia for ultrasound-guided TAP block in a pediatric patient undergoing hernia repair or hydrocelectomy. DESIGN: This is a randomized, double-blind, up-down, dose-finding study...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28157694/mathematics-anxiety-and-the-brain
#7
Ahmed A Moustafa, Richard Tindle, Zaheda Ansari, Margery J Doyle, Doaa H Hewedi, Abeer Eissa
Given that achievement in learning mathematics at school correlates with work and social achievements, it is important to understand the cognitive processes underlying abilities to learn mathematics efficiently as well as reasons underlying the occurrence of mathematics anxiety (i.e. feelings of tension and fear upon facing mathematical problems or numbers) among certain individuals. Over the last two decades, many studies have shown that learning mathematical and numerical concepts relies on many cognitive processes, including working memory, spatial skills, and linguistic abilities...
February 3, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28156132/baffled-duckweed-pond-system-for-treatment-of-agricultural-drainage-water-containing-pharmaceuticals
#8
Doaa Bassuney, Ahmed Tawfik
The aim of the study is to assess the efficiency of a novel bioremediation system namely baffled duckweed pond (BDWP) system for the treatment of agricultural drainage water containing pharmaceuticals at different hydraulic retention times (HRTs). The removal efficiencies of acetaminophen (ACT), amoxicillin (AMX), and ampicillin (AMP) increased from 69.3 ± 8.6 to 87.3 ± 3.5%, from 52.9 ± 9.4 to 82.9 ± 5.2%, and from 55.3 ± 7.9 to 90.6 ± 2.8% at increasing the HRT from 6 to 8 days, respectively. However, ACT, AMX, and AMP removal efficiencies were slightly improved at increasing the HRT from 8 to 12 days...
August 3, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28099727/association-of-biochemical-markers-with-the-severity-of-pre-eclampsia
#9
Ahmed M Maged, Gamal Aid, Nehal Bassiouny, Doaa S Eldin, Sherif Dahab, Nevein K Ghamry
OBJECTIVE: To assess the association between pre-eclampsia severity and biochemical and ultrasonography markers. METHODS: A retrospective study was undertaken of women with severe pre-eclampsia (group 1, n=90), mild pre-eclampsia (group 2, n=90), or a normal pregnancy (group 3, n=90) who attended a hospital in Egypt in October 2013-April 2015. Associations between pre-eclampsia and biochemical, cardiotocography, and ultrasonography markers were investigated. RESULTS: There were significant differences between the groups in C-reactive protein (331...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28098110/hepatitis-c-in-children-with-chronic-kidney-disease-a-single-center-egypt
#10
Doaa Mohammed Youssef, Hanaa Abdo, Ahmed Alakhras, Tamer Adham, Abdelnasser Hussien Mohamoud
Prevalence of hepatitis C varies largely according to geographical distribution, and Egypt so far has the highest prevalence worldwide. The aim of this study was to evaluate hepatitis C infection in chronic kidney disease (CKD) children in our center with regard to its incidence and other morbidities. This is a cross-sectional study involving 50 children with CKD, not on dialysis. All patients underwent a thorough history taking including disease duration and mean duration of admission, clinical examination including blood pressure measurements, and routine laboratory examination such as hemoglobin level, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28073037/amino-acid-chelated-iron-versus-an-iron-salt-in-the-treatment-of-iron-deficiency-anemia-with-pregnancy-a-randomized-controlled-study
#11
Ghada Abdel Fattah Abdel Moety, Ahmed Mahmoud Ali, Reham Fouad, Wafaa Ramadan, Doaa Shafie Belal, Hisham Mamdouh Haggag
OBJECTIVE: The aim of this study was to compare the efficacy and tolerability of iron amino acid chelate (IAAC) and ferrous fumarate (FF) in treatment of iron deficiency anemia (IDA) with pregnancy. STUDY DESIGN: A total of 150 pregnant women having iron deficiency anemia (IDA) were randomized to receive either IAAC or FF for 12 weeks. Hemoglobin, red cell indices, serum iron, and serum ferritin were measured at baseline and then 4, 8, and 12 weeks after treatment...
March 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28068153/prediction-of-fibrosis-progression-rate-in-patients-with-chronic-hepatitis-c-genotype-4-role-of-cirrhosis-risk-score-and-host-factors
#12
Tarek Besheer, Mahmoud El-Bendary, Hatem Elalfy, Mohamed Abd El-Maksoud, Mohamed Salah, Khaled Zalata, Wagdi Elkashef, Heba Elshahawy, Doaa Raafat, Wafaa Elemshaty, Noha Almashad, Hosam Zaghloul, Abdel-Hady El-Gilany, Ahmed Abdel Khalek Abdel Razek, Mohamed Abd Elwahab
The rate of liver fibrosis progression in chronic hepatitis C (CHC) patients is highly variable and affected by different factors. This study aimed to assess the role of cirrhosis risk score (CRS) based on 7 genetic variants (7 single-nucleotide polymorphisms [SNPs]) and host factors (age and sex) in the prediction of the rate of fibrosis progression in CHC. Duration of infection was determined in 115 patients. The fibrosis progression rate (FPR) per year was calculated as the ratio between fibrosis stage and the duration of infection...
March 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/27990425/comparative-evaluation-of-anthelmintic-activity-of-edible-and-ornamental-pomegranate-ethanolic-extracts-against-schistosoma-mansoni
#13
COMPARATIVE STUDY
Doaa A Yones, Dalia M Badary, Hesham M B Sayed, Soad A H Bayoumi, Azza A Khalifa, Ahmed M El-Moghazy
Due to the development of praziquantel (PZQ) schistosomes resistant strains, the discovery of new antischistosomal agents is of high priority in research. This work reported the in vitro and in vivo effects of the edible and ornamental pomegranate extracts against Schistosoma mansoni. Leaves and stem bark ethanolic extracts of both dried pomegranates were prepared at 100, 300, and 500 μg/mL for in vitro and 600 and 800 mg/kg for in vivo. Adult worms Schistosoma mansoni in RPMI-1640 medium for in vitro and S...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27930379/reliability-validity-and-sensitivity-to-change-overtime-of-the-modified-melasma-area-and-severity-index-score
#14
Doaa A E Abou-Taleb, Ahmed K Ibrahim, Eman M K Youssef, Alaa E A Moubasher
BACKGROUND: The new modified Melasma Area and Severity Index (mMASI) score, the recently used outcome measure for melasma, has not been tested to determine its sensitivity to change in melasma. OBJECTIVE: To determine the reliability, validity, and sensitivity to change overtime of the mMASI score in assessment of the severity of melasma. METHODS: Pearson correlation, Cronbach alpha, and intraclass correlation coefficient were calculated to assess the reliability of the mMASI score...
February 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27893677/impact-of-iron-deficiency-anemia-on-the-function-of-the-immune-system-in-children
#15
Tamer Hasan Hassan, Mohamed Ahmed Badr, Nehad Ahmed Karam, Marwa Zkaria, Hosam Fathy El Saadany, Doaa Mohamed Abdel Rahman, Doaa Abdallah Shahbah, Salah Mohamed Al Morshedy, Manar Fathy, Asmaa Mohamed Hosni Esh, Amal Mohamed Selim
The importance of iron deficiency as a public health problem is based ultimately on the seriousness of its consequences on health. The most extensively investigated consequences of iron deficiency involve work performance and immune function. The significance of the effects on work performance is generally accepted. In contrast, data on the influence of iron deficiency on immune function are often perceived as being confusing and contradictory.We aimed to evaluate the effect of iron deficiency anemia on humoral, cellular, nonspecific immunity, and also the effect on the cytokines that are the key factors of many immunologic steps...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27878630/diagnostic-and-prognostic-value-of-plasma-levels-of-cardiac-myosin-binding-protein-c-as-a-novel-biomarker-in-heart-failure
#16
Doaa El Amrousy, Hossam Hodeib, Ghada Suliman, Nahed Hablas, Eman Ramadan Salama, Ahmed Esam
Heart failure (HF) has high morbidity and mortality in children. This study aimed to investigate the value of cardiac myosin binding protein-C (cMyBP-C) as a diagnostic and prognostic biomarker in children with heart failure. This study was a prospective case-control study that involved 50 children with acute HF and 25 healthy children of matched age and sex as a control group. cMyBP-C plasma levels were measured in patients with HF at the time of admission and 1 month after treatment. Echocardiographic assessment was done for all children...
February 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/27877029/comments-on-the-paper-efficacies-of-globus-pallidus-stimulation-and-subthalamic-nucleus-stimulation-for-advanced-parkinson-s-disease-a-meta-analysis-of-randomized-controlled-trials
#17
COMMENT
https://www.readbyqxmd.com/read/27860335/development-of-a-synthetic-tissue-engineered-3d-printed-bioceramic-based-bone-graft-with-homogenously-distributed-osteoblasts-and-mineralizing-bone-matrix-in-vitro
#18
Doaa Adel-Khattab, Francesca Giacomini, Renate Gildenhaar, Georg Berger, Cynthia Gomes, Ulf Linow, Martin Hardt, Barbara Peleska, Jens Günster, Michael Stiller, Alireza Houshmand, Khaled Abdel Ghaffar, Ahmed Gamal, Mohamed El-Mofty, Christine Knabe
Over the last decade there have been increasing efforts to develop 3D scaffolds for bone tissue engineering from bioactive ceramics with 3D printing emerging as a promising technology. The overall objective of the present study was to generate a tissue engineered synthetic bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro, thereby mimicking the advantageous properties of autogenous bone grafts and facilitating usage for reconstructing segmental discontinuity defects in vivo...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27823571/caffeine-the-forgotten-potential-for-parkinson-s-disease
#19
Ahmed Negida, Mohamed Elfil, Attia Attia, Eslam Farahat, Mohamed Gabr, Ahmed Essam, Hussein Ahmed, Doaa Attia
Parkinson's disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies. The literature suggests that caffeine play multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk of developing PD, especially in genetically susceptible patients. On the level of Lewy bodies' formation, caffeine binds to α-synuclein protein inducing conformational changes and preventing their aggregation...
November 6, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27802917/development-and-validation-of-lc-ms-ms-assay-for-the-simultaneous-determination-of-methotrexate-6-mercaptopurine-and-its-active-metabolite-6-thioguanine-in-plasma-of-children-with-acute-lymphoblastic-leukemia-correlation-with-genetic-polymorphism
#20
Medhat A Al-Ghobashy, Said A Hassan, Doaa H Abdelaziz, Noha M Elhosseiny, Nirmeen A Sabry, Ahmed S Attia, Manal H El-Sayed
Individualized therapy is a recent approach aiming to specify dosage regimen for each patient according to its genetic state. Cancer chemotherapy requires continuous monitoring of the plasma concentration levels of active forms of cytotoxic drugs and subsequent dose adjustment. In order to attain optimum therapeutic efficacy, correlation to pharmacogenetics data is crucial. In this study, a specific, accurate and sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) has been developed for determination of methotrexate (MTX), 6-mercaptopurine (MP) and its metabolite 6-thioguanine nucleotide (TG) in human plasma...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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