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https://www.readbyqxmd.com/read/29306948/overcoming-the-crisis-of-clinical-research
#1
Giovanni A Fava, Fiammetta Cosci, Elena Tomba
No abstract text is available yet for this article.
January 6, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29306944/dealing-with-difficult-medical-colleagues
#2
Jose de Leon, Thomas N Wise, Richard Balon, Giovanni A Fava
No abstract text is available yet for this article.
January 6, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29168605/what-psychologists-need-to-know-about-psychotropic-medications
#3
Elena Tomba, Jenny Guidi, Giovanni A Fava
Despite the fact that today most of the patients with psychological disturbances assume some form of psychotropic drug treatment, clinical psychologists may have little familiarity with psychopharmacology and are substantially unaware of subtle and yet pervasive potential effects of medications in clinical presentations. In their training, psychologists are generally exposed, at best, to some general principles of drug action. Standard psychopharmacology textbooks tend to omit the subtle psychological changes that may occur during psychotropic drug treatment...
November 23, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29152138/the-hoct1-and-abcb1-polymorphisms-do-not-influence-the-pharmacodynamics-of-nilotinib-in-chronic-myeloid-leukemia
#4
Sara Galimberti, Cristina Bucelli, Elena Arrigoni, Claudia Baratè, Susanna Grassi, Federica Ricci, Francesca Guerrini, Elena Ciabatti, Carmen Fava, Antonio D'Avolio, Giulia Fontanelli, Giovanna Rege Cambrin, Alessandro Isidori, Federica Loscocco, Giovanni Caocci, Marianna Greco, Monica Bocchia, Lara Aprile, Antonella Gozzini, Barbara Scappini, Daniele Cattaneo, Anna Rita Scortechini, Giorgio La Nasa, Alberto Bosi, Pietro Leoni, Romano Danesi, Giuseppe Saglio, Giuseppe Visani, Agostino Cortelezzi, Mario Petrini, Alessandra Iurlo, Antonello Di Paolo
First-line nilotinib in chronic myeloid leukemia is more effective than imatinib to achieve early and deep molecular responses, despite poor tolerability or failure observed in one-third of patients. The toxicity and efficacy of tyrosine kinase inhibitors might depend on the activity of transmembrane transporters. However, the impact of transporters genes polymorphisms in nilotinib setting is still debated. We investigated the possible correlation between single nucleotide polymorphisms of hOCT1 (rs683369 [c...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29131122/response-to-an-evolutionary-approach-to-clinical-pharmacopsychology
#5
Per Bech, Elena Tomba, Giovanni A Fava
No abstract text is available yet for this article.
November 3, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29131050/the-clinical-inadequacy-of-the-placebo-model-and-the-development-of-an-alternative-conceptual-framework
#6
Giovanni A Fava, Jenny Guidi, Chiara Rafanelli, Karl Rickels
Placebo effects are often attributed to clinical interactions and contextual factors that affect expectations of the patient about the treatment and result in symptom changes. The prevailing conceptualization consists of an undifferentiated placebo response that needs to be minimized in controlled investigations and maximized in clinical practice. However, treatment outcome is the cumulative result of the interaction of several classes of variables with a selected treatment: living conditions (housing, nutrition, work environment, social support), patient characteristics (age, sex, genetics, general health conditions, personality, well-being), illness features and previous therapeutic experience, self-management, and treatment setting (physician's attitude and attention, illness behavior)...
November 3, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29030403/new-blood-pressure-associated-loci-identified-in-meta-analyses-of-475%C3%A2-000-individuals
#7
Aldi T Kraja, James P Cook, Helen R Warren, Praveen Surendran, Chunyu Liu, Evangelos Evangelou, Alisa K Manning, Niels Grarup, Fotios Drenos, Xueling Sim, Albert Vernon Smith, Najaf Amin, Alexandra I F Blakemore, Jette Bork-Jensen, Ivan Brandslund, Aliki-Eleni Farmaki, Cristiano Fava, Teresa Ferreira, Karl-Heinz Herzig, Ayush Giri, Franco Giulianini, Megan L Grove, Xiuqing Guo, Sarah E Harris, Christian T Have, Aki S Havulinna, He Zhang, Marit E Jørgensen, AnneMari Käräjämäki, Charles Kooperberg, Allan Linneberg, Louis Little, Yongmei Liu, Lori L Bonnycastle, Yingchang Lu, Reedik Mägi, Anubha Mahajan, Giovanni Malerba, Riccardo E Marioni, Hao Mei, Cristina Menni, Alanna C Morrison, Sandosh Padmanabhan, Walter Palmas, Alaitz Poveda, Rainer Rauramaa, Nigel William Rayner, Muhammad Riaz, Ken Rice, Melissa A Richard, Jennifer A Smith, Lorraine Southam, Alena Stančáková, Kathleen E Stirrups, Vinicius Tragante, Tiinamaija Tuomi, Ioanna Tzoulaki, Tibor V Varga, Stefan Weiss, Andrianos M Yiorkas, Robin Young, Weihua Zhang, Michael R Barnes, Claudia P Cabrera, He Gao, Michael Boehnke, Eric Boerwinkle, John C Chambers, John M Connell, Cramer K Christensen, Rudolf A de Boer, Ian J Deary, George Dedoussis, Panos Deloukas, Anna F Dominiczak, Marcus Dörr, Roby Joehanes, Todd L Edwards, Tõnu Esko, Myriam Fornage, Nora Franceschini, Paul W Franks, Giovanni Gambaro, Leif Groop, Göran Hallmans, Torben Hansen, Caroline Hayward, Oksa Heikki, Erik Ingelsson, Jaakko Tuomilehto, Marjo-Riitta Jarvelin, Sharon L R Kardia, Fredrik Karpe, Jaspal S Kooner, Timo A Lakka, Claudia Langenberg, Lars Lind, Ruth J F Loos, Markku Laakso, Mark I McCarthy, Olle Melander, Karen L Mohlke, Andrew P Morris, Colin N A Palmer, Oluf Pedersen, Ozren Polasek, Neil R Poulter, Michael A Province, Bruce M Psaty, Paul M Ridker, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Peter J Sever, Tea Skaaby, Jeanette M Stafford, John M Starr, Pim van der Harst, Peter van der Meer, Cornelia M van Duijn, Anne-Claire Vergnaud, Vilmundur Gudnason, Nicholas J Wareham, James G Wilson, Cristen J Willer, Daniel R Witte, Eleftheria Zeggini, Danish Saleheen, Adam S Butterworth, John Danesh, Folkert W Asselbergs, Louise V Wain, Georg B Ehret, Daniel I Chasman, Mark J Caulfield, Paul Elliott, Cecilia M Lindgren, Daniel Levy, Christopher Newton-Cheh, Patricia B Munroe, Joanna M M Howson
BACKGROUND: Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. METHODS AND RESULTS: Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28903113/book-received
#8
Giovanni A Fava
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28903100/from-the-lesson-of-george-engel-to-current-knowledge-the-biopsychosocial-model-40-years-later
#9
Giovanni A Fava, Nicoletta Sonino
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28889188/factors-associated-with-accelerated-subclinical-atherosclerosis-in-patients-with-spondyloarthritis-without-overt-cardiovascular-disease
#10
Alessandro Giollo, Andrea Dalbeni, Giovanni Cioffi, Federica Ognibeni, Davide Gatti, Luca Idolazzi, Giovanni Orsolini, Pietro Minuz, Maurizio Rossini, Cristiano Fava, Ombretta Viapiana
Data on the progression of atherosclerosis in spondyloarthritis (SpA) are scarce, despite a high burden of cardiovascular diseases (CVD). The aim of this study was to identify the predictors of an accelerated subclinical atherosclerosis in patients with SpA. Study participants were 66 patients free of CVD classified according to ASAS criteria. The patients were evaluated at baseline and after 13.5 ± 3.6 months. Ultrasound measurements of carotid intima-media thickness (cIMT) and distensibility coefficient (cDC) were used to assess the extent of subclinical atherosclerosis...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28634189/reduced-platelet-count-but-no-major-platelet-function-abnormalities-are-associated-with-loss-of-function-atp-binding-cassette-1-gene-mutations
#11
REVIEW
Pietro Minuz, Alessandra Meneguzzi, Eti Alessandra Femia, Cristiano Fava, Stefano Calabria, Mariangela Scavone, Donatella Benati, Giovanni Poli, Carlo Zancanaro, Sebastiano Calandra, Tiziano Lucchi, Marco Cattaneo
Loss-of-function mutations of the the ATP-binding cassette-1 (ABCA1) gene are the cause of Tangier disease (TD) in homozygous subjects and familial HDL deficiency (FHD) in heterozygous subjects. These disorders are characterized by reduced plasma HDL-cholesterol (HDL-C) and altered efflux of cholesterol from cells. Previous studies in TD patients and ABCA1(-/-) murine models reported defects in platelet count, morphology, and function, but the issue is still controversial. We analyzed three subjects with low to very low HDL-C levels due to the loss-of-function mutations of the ABCA1 gene...
August 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28532614/evidence-based-medicine-was-bound-to-fail-a-report-to-alvan-feinstein
#12
Giovanni A Fava
John Ioannidis has provided a lucid account, in the form of a report to David Sackett, of how evidence-based medicine (EBM) was hijacked to serve vested interests: major randomized controlled trials are largely done by and for the benefit of the industry; meta-analyses and guidelines are flooded with conflicts of interest; national and federal research funds are unable to address basic clinical questions. Nonetheless, EBM would remain a worthwhile goal. In this paper, in the form of a report to Alvan Feinstein, it is argued that current developments were largely predictable...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28490035/clinical-pharmacopsychology-conceptual-foundations-and-emerging-tasks
#13
Giovanni A Fava, Elena Tomba, Per Bech
The aim of this critical review was to outline emerging trends and perspectives of clinical pharmacopsychology, an area of clinical psychology that is concerned with the psychological effects of medications. The historical development of clinical pharmacopsychology is outlined, with discussion of its most representative expressions and reference to current challenges of clinical research, with particular reference to clinimetrics. The domains of clinical pharmacopsychology encompass the clinical benefits of psychotropic drugs, the characteristics that predict responsiveness to treatment, the vulnerabilities induced by treatment (side effects, behavioral toxicity, iatrogenic comorbidity), and the interactions between drug treatment and psychological variables...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28466557/the-bcr-abl1-transcript-type-influences-response-and-outcome-in-philadelphia-chromosome-positive-chronic-myeloid-leukemia-patients-treated-frontline-with-imatinib
#14
MULTICENTER STUDY
Fausto Castagnetti, Gabriele Gugliotta, Massimo Breccia, Alessandra Iurlo, Luciano Levato, Francesco Albano, Paolo Vigneri, Elisabetta Abruzzese, Giuseppe Rossi, Serena Rupoli, Francesco Cavazzini, Bruno Martino, Ester Orlandi, Patrizia Pregno, Mario Annunziata, Emilio Usala, Mario Tiribelli, Simona Sica, Massimiliano Bonifacio, Carmen Fava, Filippo Gherlinzoni, Monica Bocchia, Simona Soverini, Maria Teresa Bochicchio, Michele Cavo, Martinelli Giovanni, Giuseppe Saglio, Fabrizio Pane, Michele Baccarani, Gianantonio Rosti
The most frequent BCR-ABL1 fusion transcripts in chronic myeloid leukemia (CML) are the e13a2 (b2a2) and the e14a2 (b3a2) ones. In the imatinib era few studies addressing the prognostic significance of the BCR-ABL1 transcript type in early chronic phase CML have been published. Overall, these studies suggest that in e14a2 patients the response to imatinib is faster and deeper. To evaluate if the BCR-ABL1 transcript type (e13a2 compared to e14a2) affect the response to imatinib and the clinical outcome in newly diagnosed adult CML patients, 559 patients enrolled in 3 prospective studies (NCT00514488, NCT00510926, observational study CML/023) were analyzed...
August 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28419611/well-being-therapy-in-depression-new-insights-into-the-role-of-psychological-well-being-in-the-clinical-process
#15
Giovanni A Fava, Fiammetta Cosci, Jenny Guidi, Elena Tomba
A specific psychotherapeutic strategy for increasing psychological well-being and resilience, well-being therapy (WBT), has been developed and validated in a number of randomized controlled trials. The findings indicate that flourishing and resilience can be promoted by specific interventions leading to a positive evaluation of one's self, a sense of continued growth and development, the belief that life is purposeful and meaningful, the possession of quality relations with others, the capacity to manage effectively one's life, and a sense of self-determination...
April 18, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28297594/the-role-of-staging-in-planning-psychotherapeutic-interventions-in-depression
#16
REVIEW
Jenny Guidi, Elena Tomba, Fiammetta Cosci, Seung K Park, Giovanni A Fava
CONTEXT: The purpose of this critical review is to examine the role of staging in planning a psychotherapeutic intervention in depressive disorders. EVIDENCE ACQUISITION: English-language studies concerned with staging in depressive disorders were identified in MEDLINE, PsycINFO, and Web of Science and by manual search of the literature. Selection of articles was based on their methodological quality and implications for clinical practice. RESULTS: Staging may allow clinicians to apply a psychotherapeutic intervention to specific phases of the development of depressive disorders: certain psychotherapeutic approaches, such as well-being therapy and mindfulness-based cognitive therapy, appear to be uniquely suited for addressing the residual phase of depression, whereas interpersonal psychotherapy has been mainly tested in the acute phase...
April 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28237409/water-equivalent-thickness-of-immobilization-devices-in-proton-therapy-planning-modelling-at-treatment-planning-and-validation-by-measurements-with-a-multi-layer-ionization-chamber
#17
Francesco Fellin, Roberto Righetto, Giovanni Fava, Diego Trevisan, Dante Amelio, Paolo Farace
PURPOSE: To investigate the range errors made in treatment planning due to the presence of the immobilization devices along the proton beam path. METHODS: The measured water equivalent thickness (WET) of selected devices was measured by a high-energy spot and a multi-layer ionization chamber and compared with that predicted by treatment planning system (TPS). Two treatment couches, two thermoplastic masks (both un-stretched and stretched) and one headrest were selected...
March 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/27884006/current-psychosomatic-practice
#18
REVIEW
Giovanni A Fava, Fiammetta Cosci, Nicoletta Sonino
Psychosomatic research has advanced over the past decades in dealing with complex biopsychosocial phenomena and may provide new effective modalities of patient care. Among psychosocial variables affecting individual vulnerability, course, and outcome of any medical disease, the role of chronic stress (allostatic load/overload) has emerged as a crucial factor. Assessment strategies include the Diagnostic Criteria for Psychosomatic Research. They are presented here in an updated version based on insights derived from studies carried out so far and encompass allostatic overload, type A behavior, alexithymia, the spectrum of maladaptive illness behavior, demoralization, irritable mood, and somatic symptoms secondary to a psychiatric disorder...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27884005/the-journal-s-appreciation
#19
Giovanni A Fava
No abstract text is available yet for this article.
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/27744431/use-of-the-psychosocial-index-a-sensitive-tool-in-research-and-practice
#20
REVIEW
Antonio Piolanti, Emanuela Offidani, Jenny Guidi, Sara Gostoli, Giovanni A Fava, Nicoletta Sonino
BACKGROUND: The Psychosocial Index (PSI) is a self-rating scale based on clinimetric principles that is simple to use in a busy clinical setting. It can be integrated by observer-rated clinical judgment, providing a first-line, comprehensive assessment of stress, well-being, distress, illness behavior, and quality of life. By calculation of scores, it can be used for conventional psychological measurements. Its clinical applications and clinimetric properties are reviewed. The present version of the PSI has been slightly revised...
2016: Psychotherapy and Psychosomatics
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