keyword
https://read.qxmd.com/read/38471265/prostaglandin-e2-affects-mitochondrial-function-in-adult-mouse-cardiomyocytes-and-hearts
#21
JOURNAL ARTICLE
Timothy D Bryson, Matthew Zurek, Carlin Moore, David Taube, Indrani Datta, Albert Levin, Pamela Harding
Prostaglandin E2 (PGE2) signals differently through 4 receptor subtypes (EP1-EP4) to elicit diverse physiologic/pathologic effects. We previously reported that PGE2 via its EP3 receptor reduces cardiac contractility and male mice with cardiomyocyte-specific deletion of the EP4 receptor (EP4 KO) develop dilated cardiomyopathy. The aim of this study was to identify pathways responsible for this phenotype. We performed ingenuity pathway analysis (IPA) and found that genes differentiating WT mice and EP4 KO mice were significantly overrepresented in mitochondrial (adj...
March 6, 2024: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://read.qxmd.com/read/38464828/ferroptosis-a-new-mechanism-in-diabetic-cardiomyopathy
#22
REVIEW
Zichong Song, Jingyi Wang, Lijun Zhang
Diabetic cardiomyopathy (DC) is a pathophysiologic condition caused by diabetes mellitus (DM) in the absence of coronary artery disease, valvular heart disease, and hypertension that can lead to heart failure (HF), manifesting itself in the early stages with left ventricular hypertrophy and diastolic dysfunction, with marked HF and decreased systolic function in the later stages. There is still a lack of direct evidence to prove the exact existence of DC. Ferroptosis is a novel form of cell death characterized by reactive oxygen species (ROS) accumulation and lipid peroxidation...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38464205/the-ubiquitin-ligase-rbx2-sag-regulates-mitochondrial-ubiquitination-and-mitophagy
#23
Wenjuan Wang, Ermin Li, Jianqiu Zou, Qu Chen, Juan Ayala, Yuan Wen, Md Sadikul Islam, Neal L Weintraub, David J Fulton, Qiangrong Liang, Jiliang Zhou, Jinbao Liu, Jie Li, Yi Sun, Huabo Su
UNLABELLED: Clearance of damaged mitochondria via mitophagy is crucial for cellular homeostasis. While the role of ubiquitin (Ub) ligase PARKIN in mitophagy has been extensively studied, increasing evidence suggests the existence of PARKIN-independent mitophagy in highly metabolically active organs such as the heart. Here, we identify a crucial role for Cullin-RING Ub ligase 5 (CRL5) in basal mitochondrial turnover in cardiomyocytes. CRL5 is a multi-subunit Ub ligase comprised by the catalytic RING box protein RBX2 (also known as SAG), scaffold protein Cullin 5 (CUL5), and a substrate-recognizing receptor...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38461630/traditional-chinese-medicine-and-mitophagy-a-novel-approach-for-cardiovascular-disease-management
#24
REVIEW
Jinhui Wang, Junbo Zou, Yajun Shi, Nan Zeng, Dongyan Guo, He Wang, Chongbo Zhao, Fei Luan, Xiaofei Zhang, Jing Sun
BACKGROUND: Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, imposing an enormous economic burden on individuals and human society. Laboratory studies have identified several drugs that target mitophagy for the prevention and treatment of CVD. Only a few of these drugs have been successful in clinical trials, and most studies have been limited to animal and cellular models. Furthermore, conventional drugs used to treat CVD, such as antiplatelet agents, statins, and diuretics, often result in adverse effects on patients' cardiovascular, metabolic, and respiratory systems...
February 24, 2024: Phytomedicine
https://read.qxmd.com/read/38459019/n-acetyltransferase-10-represses-uqcr11-and-uqcrb-independently-of-ac4c-modification-to-promote-heart-regeneration
#25
JOURNAL ARTICLE
Wenya Ma, Yanan Tian, Leping Shi, Jing Liang, Qimeng Ouyang, Jianglong Li, Hongyang Chen, Hongyue Sun, Haoyu Ji, Xu Liu, Wei Huang, Xinlu Gao, Xiaoyan Jin, Xiuxiu Wang, Yining Liu, Yang Yu, Xiaofei Guo, Ye Tian, Fan Yang, Faqian Li, Ning Wang, Benzhi Cai
Translational control is crucial for protein production in various biological contexts. Here, we use Ribo-seq and RNA-seq to show that genes related to oxidative phosphorylation are translationally downregulated during heart regeneration. We find that Nat10 regulates the expression of Uqcr11 and Uqcrb mRNAs in mouse and human cardiomyocytes. In mice, overexpression of Nat10 in cardiomyocytes promotes cardiac regeneration and improves cardiac function after injury. Conversely, treating neonatal mice with Remodelin-a Nat10 pharmacological inhibitor-or genetically removing Nat10 from their cardiomyocytes both inhibit heart regeneration...
March 8, 2024: Nature Communications
https://read.qxmd.com/read/38458046/nanomedicine-alleviates-doxorubicin-induced-cardiotoxicity-and-enhances-chemotherapy-synergistic-chemodynamic-therapy
#26
JOURNAL ARTICLE
Yaqian He, Xiaoying Liu, Zichuang Xu, Jiajun Gao, Qingzhi Luo, Yuchu He, Xuwu Zhang, Dawei Gao, Desong Wang
Doxorubicin (DOX) is widely used in clinic as a broad-spectrum chemotherapy drug, which can enhance the efficacy of chemodynamic therapy (CDT) by interfering tumor-related metabolize to increase H2 O2 content. However, DOX can induce serious cardiomyopathy (DIC) due to its oxidative stress in cardiomyocytes. Eliminating oxidative stress would create a significant opportunity for the clinical application of DOX combined with CDT. To address this issue, we introduced sodium ascorbate (AscNa), the main reason is that AscNa can be catalyzed to produce H2 O2 by the abundant Fe3+ in the tumor site, thereby enhancing CDT...
March 4, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38447978/quercetin-inhibits-necroptosis-in-cardiomyocytes-after-ischemia-reperfusion-via-dna-pkcs-sirt5-orchestrated-mitochondrial-quality-control
#27
JOURNAL ARTICLE
Xing Chang, Qin Zhang, Yu Huang, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Zhiming Liu, Ruxiu Liu
We investigated the mechanism by which quercetin preserves mitochondrial quality control (MQC) in cardiomyocytes subjected to ischemia-reperfusion stress. An enzyme-linked immunosorbent assay was employed in the in vivo experiments to assess myocardial injury markers, measure the transcript levels of SIRT5/DNAPK-cs/MLKL during various time intervals of ischemia-reperfusion, and observe structural changes in cardiomyocytes using transmission electron microscopy. In in vitro investigations, adenovirus transfection was employed to establish a gene-modified model of DNA-PKcs, and primary cardiomyocytes were obtained from a mouse model with modified SIRT5 gene...
March 6, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38444138/-role-of-mitochondrial-dynamics-in-diabetic-cardiomyopathy-and-regulatory-mechanisms
#28
REVIEW
Huan Yue, De-Ma De, Ming-Ge Ding, Feng Fu
Cardiovascular complications are the leading cause of death in diabetic patients. Among them, diabetic cardiomyopathy (DCM) is a type of specific cardiomyopathy excluding myocardial damage caused by hypertension and coronary heart disease. It is characterized by abnormal metabolism of cardiomyocytes and gradual decline of cardiac function. The clinical manifestations of DCM are impaired diastolic function in early stage and impaired systolic function in late stage. Eventually it developed into heart failure...
February 25, 2024: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://read.qxmd.com/read/38443933/morn2-regulates-the-morphology-and-energy-metabolism-of-mitochondria-and-is-required-for-male-fertility-in-mice
#29
JOURNAL ARTICLE
Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang, Tao Huang
BACKGROUND: Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and asthenospermia. The mitochondrial sheath is a component of the mid-piece of the sperm flagellum, and dysfunction of the sheath can reduce sperm motility and cause male infertility. The membrane occupation and recognition nexus-motif protein 2 (MORN2) is testis enriched in mice, and the MORN motif was reported to play a role in the regulation of bioelectrical signal homeostasis in cardiomyocytes...
March 5, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38438604/cdc-like-kinase-3-deficiency-aggravates-hypoxia-induced-cardiomyocyte-apoptosis-through-akt-signaling-pathway
#30
JOURNAL ARTICLE
Xiue Ma, Liming Gao, Rucun Ge, Tianyou Yuan, Bowen Lin, Lixiao Zhen
Hypoxia-induced cardiomyocyte apoptosis is one major pathological change of acute myocardial infarction (AMI), but the underlying mechanism remains unexplored. CDC-like kinase 3 (CLK3) plays crucial roles in cell proliferation, migration and invasion, and nucleotide metabolism, however, the role of CLK3 in AMI, especially hypoxia-induced apoptosis, is largely unknown. The expression of CLK3 was elevated in mouse myocardial infarction (MI) models and neonatal rat ventricular myocytes (NRVMs) under hypoxia. Furthermore, CLK3 knockdown significantly promoted apoptosis and inhibited NRVM survival, while CLK3 overexpression promoted NRVM survival and inhibited apoptosis under hypoxic conditions...
March 4, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38437927/cardiac-resolvin-d2-ameliorates-sepsis-induced-cardiomyopathy-via-inhibiting-caspase-11-gsdmd-dependent-pyroptosis
#31
JOURNAL ARTICLE
Wen-Wu Zhang, Shun-Shun Wang, Yang-Dong Ding, Xin-Yi Wu, Jin-Ling Wei, Ye Gao, Sheng-Wei Jin, Pu-Hong Zhang
BACKGROUND: Sepsis-induced cardiomyopathy (SICM) is common complication in septic patients with a high mortality and is characterized by an abnormal inflammation response, which was precisely regulated by endogenous specialized pro-resolving mediators (SPMs). However, the metabolic changes of cardiac SPMs during SICM and the roles of SPMs subset in the development of SICM remain unknown. METHODS: In this work, the SPMs concentration was assessed using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) of SICM mice and SICM patients...
March 2, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38429992/risk-based-prioritization-of-pfas-using-phenotypic-and-transcriptomic-data-from-human-induced-pluripotent-stem-cell-derived-hepatocytes-and-cardiomyocytes
#32
JOURNAL ARTICLE
Han-Hsuan D Tsai, Lucie C Ford, Zunwei Chen, Allison N Dickey, Fred A Wright, Ivan Rusyn
Per- and polyfluoroalkyl substances (PFAS) are chemicals with important applications; they are persistent in the environment and may pose human health hazards. Regulatory agencies are considering restrictions and bans of PFAS; however, little data exists for informed decisions. Several prioritization strategies were proposed for evaluation of potential hazards of PFAS. Structure-based grouping could expedite the selection of PFAS for testing; still, the hypothesis that structure-effect relationships exist for PFAS requires confirmation...
February 22, 2024: ALTEX
https://read.qxmd.com/read/38428029/large-animal-models-of-pressure-overload-induced-cardiac-left-ventricular-hypertrophy-to-study-remodeling-of-the-human-heart-with-aortic-stenosis
#33
JOURNAL ARTICLE
Evangelia Beslika, Adelino Leite-Moreira, Leon J De Windt, Paula da Costa Martins
Pathologic cardiac hypertrophy is a common consequence of many cardiovascular diseases, including aortic stenosis. Aortic stenosis is known to increase the pressure load of the left ventricle, causing a compensative response of the cardiac muscle, which progressively will lead to dilation and heart failure. In a cellular level, this corresponds to a considerable increase in the size of cardiomyocytes, named cardiomyocyte hypertrophy, as their proliferation capacity is attenuated upon the first developmental stages...
March 1, 2024: Cardiovascular Research
https://read.qxmd.com/read/38424223/hygrothermal-stress-increases-malignant-arrhythmias-susceptibility-by-inhibiting-the-lkb1-ampk-cx43-pathway
#34
JOURNAL ARTICLE
Jianing Chi, Ningxia Wu, Pengfei Li, Jiaman Hu, Hua Cai, Cailong Lin, Yingying Lai, Han Yang, Jianyu Huang, Min Li, Lin Xu
High mortality due to hygrothermal stress during heat waves is mostly linked to cardiovascular malfunction, the most serious of which are malignant arrhythmias. However, the mechanism associated with hygrothermal stress leading to malignant arrhythmias remains unclear. The energy metabolism regulated by liver kinase B1 (LKB1) and adenosine monophosphate-activated protein kinase (AMPK) and the electrical signaling based on gap junction protein, connexin43 (Cx43), plays important roles in the development of cardiac arrhythmias...
February 29, 2024: Scientific Reports
https://read.qxmd.com/read/38422177/glycolysis-mediated-activation-of-v-atpase-by-nicotinamide-mononucleotide-ameliorates-lipid-induced-cardiomyopathy-by-repressing-the-cd36-tlr4-axis
#35
JOURNAL ARTICLE
Shujin Wang, Yinying Han, Ruimin Liu, Mengqian Hou, Dietbert Neumann, Jun Zhang, Fang Wang, Yumeng Li, Xueya Zhao, Francesco Schianchi, Chao Dai, Lizhong Liu, Miranda Nabben, Jan F C Glatz, Xin Wu, Xifeng Lu, Xi Li, Joost J F P Luiken
BACKGROUND: Chronic overconsumption of lipids followed by their excessive accumulation in the heart leads to cardiomyopathy. The cause of lipid-induced cardiomyopathy involves a pivotal role for the proton-pump vacuolar-type H+ -ATPase (v-ATPase), which acidifies endosomes, and for lipid-transporter CD36, which is stored in acidified endosomes. During lipid overexposure, an increased influx of lipids into cardiomyocytes is sensed by v-ATPase, which then disassembles, causing endosomal de-acidification and expulsion of stored CD36 from the endosomes toward the sarcolemma...
March 2024: Circulation Research
https://read.qxmd.com/read/38422175/cardiovascular-consequences-of-uremic-metabolites-an-overview-of-the-involved-signaling-pathways
#36
REVIEW
Adelina Curaj, Raymond Vanholder, Joseph Loscalzo, Kaiseng Quach, Zhuojun Wu, Vera Jankowski, Joachim Jankowski
The crosstalk of the heart with distant organs such as the lung, liver, gut, and kidney has been intensively approached lately. The kidney is involved in (1) the production of systemic relevant products, such as renin, as part of the most essential vasoregulatory system of the human body, and (2) in the clearance of metabolites with systemic and organ effects. Metabolic residue accumulation during kidney dysfunction is known to determine cardiovascular pathologies such as endothelial activation/dysfunction, atherosclerosis, cardiomyocyte apoptosis, cardiac fibrosis, and vascular and valvular calcification, leading to hypertension, arrhythmias, myocardial infarction, and cardiomyopathies...
March 2024: Circulation Research
https://read.qxmd.com/read/38421727/hspa12a-maintains-aerobic-glycolytic-homeostasis-and-histone3-lactylation-in-cardiomyocytes-to-attenuate-myocardial-ischemia-reperfusion-injury
#37
JOURNAL ARTICLE
Wansu Yu, Qiuyue Kong, Surong Jiang, Yunfan Li, Zhaohe Wang, Qian Mao, Xiaojin Zhang, Qianhui Liu, Pengjun Zhang, Yuehua Li, Chuanfu Li, Zhengnian Ding, Li Liu
Myocardial ischemia/reperfusion (MI/R) injury is a major cause of adverse outcomes of revascularization following myocardial infarction. Anaerobic glycolysis during myocardial ischemia is well-studied, but the role of aerobic glycolysis during the early phase of reperfusion is incompletely understood. Lactylation of Histone H3 (H3) is an epigenetic indicator of the glycolytic switch. Heat shock protein A12A (HSPA12A) is an atypic member of the HSP70 family. In the present study, we report that during reperfusion following myocardial ischemia, HSPA12A was downregulated and aerobic glycolytic flux was decreased in cardiomyocytes...
February 29, 2024: JCI Insight
https://read.qxmd.com/read/38414784/lithium-downregulates-phosphorylated-acetyl%C3%A2-coa-carboxylase-2-and-attenuates-mitochondrial-fatty-acid-utilization-and-oxidative-stress-in-cardiomyocytes
#38
JOURNAL ARTICLE
Pao-Huan Chen, Ting-Wei Lee, Shuen-Hsin Liu, Tin Van Huynh, Cheng-Chih Chung, Yung-Hsin Yeh, Yu-Hsun Kao, Yi-Jen Chen
Acetyl-CoA carboxylase 2 plays a crucial role in regulating mitochondrial fatty acid oxidation in cardiomyocytes. Lithium, a monovalent cation known for its cardioprotective potential, has been investigated for its influence on mitochondrial bioenergetics. The present study explored whether lithium modulated acetyl-CoA carboxylase 2 and mitochondrial fatty acid metabolism in cardiomyocytes and the potential therapeutic applications of lithium in alleviating metabolic stress. Mitochondrial bioenergetic function, fatty acid oxidation, reactive oxygen species production, membrane potential and the expression of proteins involved in fatty acid metabolism in H9c2 cardiomyocytes treated with LiCl for 48 h was measured by using a Seahorse extracellular flux analyzer, fluorescence microscopy and western blotting...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38409164/targeting-hdac6-to-treat-heart-failure-with-preserved-ejection-fraction-in-mice
#39
JOURNAL ARTICLE
Sara Ranjbarvaziri, Aliya Zeng, Iris Wu, Amara Greer-Short, Farshad Farshidfar, Ana Budan, Emma Xu, Reva Shenwai, Matthew Kozubov, Cindy Li, Melissa Van Pell, Francis Grafton, Charles E MacKay, Xiaomei Song, James R Priest, Gretchen Argast, Mohammad A Mandegar, Timothy Hoey, Jin Yang
Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to the limited treatment options. Building upon our previous research that demonstrates the efficacy of histone deacetylase 6 (HDAC6) inhibition in a genetic cardiomyopathy model, we investigate HDAC6's role in HFpEF due to their shared mechanisms of inflammation and metabolism. Here, we show that inhibiting HDAC6 with TYA-018 effectively reverses established heart failure and its associated symptoms in male HFpEF mouse models...
February 26, 2024: Nature Communications
https://read.qxmd.com/read/38405061/epigenetic-modifications-in-obesity-associated-diseases
#40
REVIEW
Yiqian Long, Chao Mao, Shuang Liu, Yongguang Tao, Desheng Xiao
The global prevalence of obesity has reached epidemic levels, significantly elevating the susceptibility to various cardiometabolic conditions and certain types of cancer. In addition to causing metabolic abnormalities such as insulin resistance (IR), elevated blood glucose and lipids, and ectopic fat deposition, obesity can also damage pancreatic islet cells, endothelial cells, and cardiomyocytes through chronic inflammation, and even promote the development of a microenvironment conducive to cancer initiation...
February 2024: MedComm
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