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cardiomyocyte and metabolism

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https://www.readbyqxmd.com/read/29146190/newly-developed-selective-immunoinactivation-assay-revealed-reduction-in-adipose-triglyceride-lipase-activity-in-peripheral-leucocytes-from-patients-with-idiopathic-triglyceride-deposit-cardiomyovasculopathy
#1
Atsuko Takagi, Yasuyuki Ikeda, Kunihisa Kobayashi, Kazuhiro Kobayashi, Yoshihiko Ikeda, Junji Kozawa, Hideyuki Miyauchi, Ming Li, Chikako Hashimoto, Yasuhiro Hara, Satoshi Yamaguchi, Akira Suzuki, Tatsushi Toda, Hironori Nagasaka, Ken-Ichi Hirano
Triglyceride deposit cardiomyovasculopathy (TGCV) is a rare and newly identified disease among patients requiring cardiac transplantation. TGCV is characterized by cardiomyocyte steatosis and triglyceride (TG)-deposit atherosclerosis, resulting from the abnormal intracellular metabolism of TG. TGCV is classified into primary and idiopathic types. Primary TGCV carries ultra-rare genetic mutations in the adipose triglyceride lipase (ATGL), a rate-liming enzyme that hydrolyzes intracellular TG in adipose and non-adipose tissues...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29133820/early-postnatal-cardiomyocyte-proliferation-requires-high-oxidative-energy-metabolism
#2
Ana Elisa Teófilo Saturi de Carvalho, Vinícius Bassaneze, Maria Fernanda Forni, Aline Alfonso Keusseyan, Alicia Juliana Kowaltowski, José Eduardo Krieger
Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related gene expression does not correlate with functional oxidative measurements in the developing heart. Gene expression analysis suggests a gradual overall upregulation of oxidative-related genes and pathways, whereas functional assessment in both cardiac tissue and cultured cardiomyocytes indicated that oxidative metabolism decreases between the first and seventh days after birth...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133341/the-trafficking-protein-ehd2-positively-regulates-cardiac-sarcolemmal-katp-channel-surface-expression-role-in-cardioprotection
#3
Hua Qian Yang, Kundan Jana, Michael J Rindler, William A Coetzee
ATP-sensitive K(+) (KATP) channels uniquely link cellular energy metabolism to membrane excitability and are expressed in diverse cell types that range from the endocrine pancreas to neurons and smooth, skeletal, and cardiac muscle. A decrease in the surface expression of KATP channels has been linked to various disorders, including dysregulated insulin secretion, abnormal blood pressure, and impaired resistance to cardiac injury. In contrast, up-regulation of KATP channel surface expression may be protective, for example, by mediating the beneficial effect of ischemic preconditioning...
November 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29130531/acute-hypoxic-preconditioning-prevents-palmitic-acid-induced-cardiomyocyte-apoptosis-via-switching-metabolic-glut4-glucose-pathway-back-to-cd36-fatty-acid-dependent
#4
Yeh-Peng Chen, Wei-Wen Kuo, Rathinasamy Baskaran, Cecilia-Hsuan Day, Ray-Jade Chen, Su-Ying Wen, Tsung-Jung Ho, Viswanadha Vijaya Padma, Chia-Hua Kuo, Chih-Yang Huang
Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myocardial cell damage leads to an imbalance of energy metabolism, and many studies have indicated that short-term hypoxia during myocardial cell injury has a protective effect. In our previous animal studies, we found that short-term hypoxia in the heart has a protective effect, but long-term hypoxia increases myocardial cell injury. Palmitic acid (PA)-treated H9c2 cardiomyoblasts and neonatal rat ventricle cardiomyocytes were used to simulate hyperlipidemia model, which suppress cluster of differentiation 36 (CD36) and activate glucose transporter type 4 (GLUT4)...
November 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29115400/global-gene-expression-analysis-combined-with-a-genomics-approach-for-the-identification-of-signal-transduction-networks-involved-in-postnatal-mouse-myocardial-proliferation-and-development
#5
Ruoxin Wang, Chao Su, Xinting Wang, Qiang Fu, Xingjie Gao, Chunyan Zhang, Jie Yang, Xi Yang, Minxin Wei
Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of cardiomyocytes during the postnatal period may enhance the current understanding regarding this molecular mechanism. The present study identified the differentially expressed genes in hearts obtained from 24 h‑old mice, which contain proliferative cardiomyocytes; 7‑day‑old mice, in which the cardiomyocytes are undergoing a proliferative burst; and 10‑week‑old mice, which contain growth‑arrested cardiomyocytes, using global gene expression analysis...
November 3, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29111822/repercussions-of-hypo-and-hyperthyroidism-on-the-heart-circadian-clock
#6
Rodrigo A Peliciari-Garcia, Paula Bargi-Souza, Martin E Young, Maria Tereza Nunes
Myocardial gene expression and metabolism fluctuate over the course of the day in association with changes in energy supply and demand. Time-of-day-dependent oscillations in myocardial processes have been linked to the intrinsic cardiomyocyte circadian clock. Triiodothyronine (T3) is an important modulator of heart metabolism and function. Recently, our group has reported time-of-day-dependent rhythms in cardiac T3 sensitivity, as well as, T3-mediated acute alterations on core clock components. Hypo and hyperthyroidism are the second most prevalent endocrine disease worldwide...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29109032/molecular-mechanisms-of-cardiac-pathology-in-diabetes-experimental-insights
#7
REVIEW
U Varma, P Koutsifeli, V L Benson, K M Mellor, L M D Delbridge
Diabetic cardiomyopathy is a distinct pathology independent of co-morbidities such as coronary artery disease and hypertension. Diminished glucose uptake due to impaired insulin signaling and decreased expression of glucose transporters is associated with a shift towards increased reliance on fatty acid oxidation and reduced cardiac efficiency in diabetic hearts. The cardiac metabolic profile in diabetes is influenced by disturbances in circulating glucose, insulin and fatty acids, and alterations in cardiomyocyte signaling...
November 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29107282/the-autonomic-nervous-system-and-cardiac-glp-1-receptors-control-heart-rate-in-mice
#8
Laurie L Baggio, John R Ussher, Brent A McLean, Xiemin Cao, M Golam Kabir, Erin E Mulvihill, Alexandra S Mighiu, Hangjun Zhang, Andreas Ludwig, Randy J Seeley, Scott P Heximer, Daniel J Drucker
OBJECTIVES: Glucagon-like peptide-1 (GLP-1) is secreted from enteroendocrine cells and exerts a broad number of metabolic actions through activation of a single GLP-1 receptor (GLP-1R). The cardiovascular actions of GLP-1 have garnered increasing attention as GLP-1R agonists are used to treat human subjects with diabetes and obesity that may be at increased risk for development of heart disease. Here we studied mechanisms linking GLP-1R activation to control of heart rate (HR) in mice...
November 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29101900/glutaredoxin-2-controls-cardiac-mitochondrial-dynamics-and-energetics-in-mice-and-protects-against-human-cardiac-pathologies
#9
Georges N Kanaan, Bianca Ichim, Lara Gharibeh, Wael Maharsy, David A Patten, Jian Ying Xuan, Arkadiy Reunov, Philip Marshall, John Veinot, Keir Menzies, Mona Nemer, Mary-Ellen Harper
Glutaredoxin 2 (GRX2), a mitochondrial glutathione-dependent oxidoreductase, is central to glutathione homeostasis and mitochondrial redox, which is crucial in highly metabolic tissues like the heart. Previous research showed that absence of Grx2, leads to impaired mitochondrial complex I function, hypertension and cardiac hypertrophy in mice but the impact on mitochondrial structure and function in intact cardiomyocytes and in humans has not been explored. We hypothesized that Grx2 controls cardiac mitochondrial dynamics and function in cellular and mouse models, and that low expression is associated with human cardiac dysfunction...
October 26, 2017: Redox Biology
https://www.readbyqxmd.com/read/29099710/vitamins-d-and-e-combined-effect-on-the-rat-myocardium-under-alloxan-induced-diabetes
#10
B Osipiani, T Machavariani, T Gvamichava, I Gachechiladze, E Nikobadze
It is commonly known that in diabetes mellitus the risk of cardiovascular diseases and mortality increases. The purpose of this study was to determine the specific features of the morphological restructuring of the myocardium in the early stage of experimental diabetes and use the combined impact of powerful antioxidants (Vitamin C and Vitamin E) on the rat myocardium in conditions of alloxan-induced diabetes. The experimental animals were divided into three groups: 40 rats were the target, and 20 rats were the control...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29092858/chronic-maternal-hypercortisolemia-in-late-gestation-alters-fetal-cardiac-function-at-birth
#11
Andrew Antolic, Charles E Wood, Maureen Keller-Wood
Studies in our laboratory have shown that modest chronic increases in maternal cortisol concentrations over the last 0.20 of gestation impair maternal glucose metabolism and increase the incidence of perinatal stillbirth. Previous studies had found an increase in maternal cortisol concentrations from 115 to 130d gestation in sheep increased both proliferation in fetal cardiomyocytes and apoptosis in the fetal cardiac Purkinje Fibers. We hypothesized that the adverse effects of excess cortisol may result in defects in cardiac conduction during labor and delivery...
November 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29079702/metallothionein-preserves-akt2-activity-and-cardiac-function-via-inhibiting-trb3-in-diabetic-hearts
#12
Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T Barati, Chi Zhang, Yang Bai, Yan Li, Paul N Epstein, Kupper A Wintergerst, Xiaokun Li, Yi Tan, Lu Cai
Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy (DCM), but the mechanism remains largely unclear. We found that diabetic hearts exhibited decreased phosphorylation of total Akt and isoform Akt2 but not Akt1 in wild type (WT) male FVB mice, which was accompanied by attenuation of Akt downstream glucose metabolic signal; All these signal changes were not observed in metallothionein cardiac-specific transgenic (MT-TG) hearts. Furthermore, insulin-induced glucose metabolic signals were attenuated only in WT diabetic hearts...
October 27, 2017: Diabetes
https://www.readbyqxmd.com/read/29074824/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-and-bone-mineral-metabolism
#13
Ritsuko Masuyama
Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1α,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. The biological significance of 1α,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic β cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29073097/content-of-mitochondrial-calcium-uniporter-mcu-in-cardiomyocytes-is-regulated-by-microrna-1-in-physiologic-and-pathologic-hypertrophy
#14
Tania Zaglia, Paola Ceriotti, Antonio Campo, Giulia Borile, Andrea Armani, Pierluigi Carullo, Valentina Prando, Raffaele Coppini, Vladimiro Vida, Tomas O Stølen, Wisløff Ulrik, Elisabetta Cerbai, Giovanni Stellin, Giuseppe Faggian, Diego De Stefani, Marco Sandri, Rosario Rizzuto, Fabio Di Lisa, Tullio Pozzan, Daniele Catalucci, Marco Mongillo
The mitochondrial Ca(2+) uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca(2+) influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca(2+) uptake is fundamental for cardiomyocytes to adapt to either physiologic or pathologic stresses. Mitochondrial calcium uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a critical role in the response to β-adrenoreceptor stimulation occurring during acute exercise...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29069231/myostatin-promotes-distinct-responses-on-protein-metabolism-of-skeletal-and-cardiac-muscle-fibers-of-rodents
#15
L H Manfredi, S Paula-Gomes, N M Zanon, I C Kettelhut
Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Herein, we used cell cultures and isolated muscles from rats to determine protein degradation and synthesis. Muscles incubated with myostatin exhibited an increase in proteolysis with an increase of Atrogin-1, MuRF1 and LC3 genes...
October 19, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29063982/role-of-beta-adrenergic-receptors-and-sirtuin-signaling-in-the-heart-during-aging-heart-failure-and-adaptation-to-stress
#16
REVIEW
Regina Celia Spadari, Claudia Cavadas, Ana Elisa T Saturi de Carvalho, Daniela Ortolani, Andre Luiz de Moura, Paula Frizera Vassalo
In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (β-ARs), mainly the beta 1 (β1-AR) and beta 2 (β2-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. The β2-ARs can also couple to the Gi protein that counterbalances the effect of the Gs protein on cyclic adenosine monophosphate production and activates the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. In several cardiovascular disorders, including heart failure, as well as in aging and in animal models of environmental stress, a reduction in the β1/β2-AR ratio and activation of the β2-AR-Gi-PI3K-Akt signaling pathway have been observed...
October 24, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29062050/functional-expression-and-pharmaceutical-efficacy-of-cardiac-specific-ion-channels-in-human-embryonic-stem-cell-derived-cardiomyocytes
#17
Han Sol Kim, Jung Won Yoon, Hongliang Li, Geun Ok Jeong, Jin Ju Park, Sung Eun Shin, Il Ho Jang, Jae Ho Kim, Won Sun Park
Cardiomyocytes differentiated from human pluripotent stem cells provide promising tools for screening of cardiotoxic drugs. For evaluation of human pluripotent stem cell-derived cardiomyocytes for cardiotoxicity test, in the present study, human embryonic stem cells (hESCs) were differentiated to cardiomyocytes, followed by metabolic selection to enrich the differentiated cardiomyocytes. The highly purified hESC-derived cardiomyocytes (hESC-CMs) expressed several cardiomyocyte-specific markers including cTnT, MLC2a, and α-SA, but not pluripotency markers, such as OCT4 and NANOG...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29058176/demonstration-of-subcellular-migration-of-ck2%C3%AE-localization-from-nucleus-to-sarco-endo-plasmic-reticulum-in-mammalian-cardiomyocytes-under-hyperglycemia
#18
Ceylan Verda Bitirim, Erkan Tuncay, Belma Turan
The cellular control of glucose uptake and glycogen metabolism in mammalian tissues is in part mediated through the regulation of protein-serine/threonine kinases including CK2. Although it participates to several cellular signaling processes, however, its subcellular localization is not well-defined while some documents mentioned its localization change under pathological conditions. The activation/phosphorylation of some proteins including Zn(2+)-transporter ZIP7 in cardiomyocytes is controlled with CK2α, thereby, inducing changes in the level of intracellular free Zn(2+) ([Zn(2+)] i )...
October 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29057537/cpg-oligodeoxynucleotide-preconditioning-improves-cardiac-function-after-myocardial-infarction-via-modulation-of-energy-metabolism-and-angiogenesis
#19
Deng-Cheng Zhou, Yong-Hui Su, Fu-Qing Jiang, Jing-Bo Xia, Hai-Yan Wu, Zao-Shang Chang, Wen-Tao Peng, Guo-Hua Song, Kyu-Sang Park, Soo-Ki Kim, Dong-Qing Cai, Li Zheng, Xu-Feng Qi
Unmethylated CpG oligodeoxynucleotide (CpG-ODN), a Toll-like receptor 9 (TLR9) ligand, has been shown to protect against myocardial ischemia/reperfusion injury. However, the potential effects of CpG-ODN on myocardial infarction (MI) induced by persistent ischemia remains unclear. Here, we investigated whether and how CpG-ODN preconditioning protects against MI in mice. C57BL/6 mice were treated with CpG-ODN by i.p. injection 2 hours prior to MI induction, and cardiac function and histology were analyzed two weeks after MI...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29038558/prokineticin-receptor-1-dependent-paracrine-and-autocrine-pathways-control-cardiac-tcf21-fibroblast-progenitor-cell-transformation-into-adipocytes-and-vascular-cells
#20
Rehana Qureshi, Michel Kindo, Himanshu Arora, Mounia Boulberdaa, Marja Steenman, Canan G Nebigil
Cardiac fat tissue volume and vascular dysfunction are strongly associated, accounting for overall body mass. Despite its pathophysiological significance, the origin and autocrine/paracrine pathways that regulate cardiac fat tissue and vascular network formation are unclear. We hypothesize that adipocytes and vasculogenic cells in adult mice hearts may share a common cardiac cells that could transform into adipocytes or vascular lineages, depending on the paracrine and autocrine stimuli. In this study utilizing transgenic mice overexpressing prokineticin receptor (PKR1) in cardiomyocytes, and tcf21ERT-cre(TM)-derived cardiac fibroblast progenitor (CFP)-specific PKR1 knockout mice (PKR1 (tcf-/-)), as well as FACS-isolated CFPs, we showed that adipogenesis and vasculogenesis share a common CFPs originating from the tcf21(+) epithelial lineage...
October 16, 2017: Scientific Reports
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